Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone

Momoko Fukuda, Yuki Fujita, Yuko Hino, Mitsuyoshi Nakao, Katsuhiko Shirahige, Toshihide Yamashita

International Journal of Molecular Sciences　Vol. 25　No. 5　p. 2540-2540　2024/02/22　Research paper (scientific journal)

Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction.

Bin Hong, Yosuke Ohtake, Takahide Itokazu, Toshihide Yamashita

Cell death discovery　Vol. 10　No. 1　p. 50-50　2024/01/26　Research paper (scientific journal)

RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS

Mikito Shimizu, Naoyuki Shiraishi, Satoru Tada, Tsutomu Sasaki, Goichi Beck, Seiichi Nagano, Makoto Kinoshita, Hisae Sumi, Tomoyuki Sugimoto, Yoko Ishida, Toru Koda, Teruyuki Ishikura, Yasuko Sugiyama, Keigo Kihara, Minami Kanakura, Tsuneo Nakajima, Shuko Takeda, Masanori P. Takahashi, Toshihide Yamashita, Tatsusada Okuno, Hideki Mochizuki

Science Advances　Vol. 9　No. 47　2023/11/24　Research paper (scientific journal)

Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases

Abdellatif Abbaoui, Oluwaseun Fatoba, Toshihide Yamashita

Frontiers in Cellular Neuroscience　Vol. 17　2023/08/07　Research paper (scientific journal)

Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys

Masahiro Sawada, Kimika Yoshino-Saito, Taihei Ninomiya, Takao Oishi, Toshihide Yamashita, Hirotaka Onoe, Masahiko Takada, Yukio Nishimura, Tadashi Isa

eneuro　p. ENEURO.0209-23.2023　2023/07/19　Research paper (scientific journal)

Dominant-negative variants in CBX1 cause a neurodevelopmental disorder.

Yukiko Kuroda, Aiko Iwata-Otsubo, Kerith-Rae Dias, Suzanna E L Temple, Koji Nagao, Lachlan De Hayr, Ying Zhu, Shin-Ya Isobe, Gohei Nishibuchi, Sarah K Fiordaliso, Yuki Fujita, Alyssa L Rippert, Samuel W Baker, Marco L Leung, Daniel C Koboldt, Adele Harman, Beth A Keena, Izumi Kazama, Gopinath Musuwadi Subramanian, Kandamurugu Manickam, Betsy Schmalz, Maeson Latsko, Elaine H Zackai, Matt Edwards, Carey-Anne Evans, Matthew C Dulik, Michael F Buckley, Toshihide Yamashita, W Timothy O'Brien, Robert J Harvey, Chikashi Obuse, Tony Roscioli, Kosuke Izumi

Genetics in medicine : official journal of the American College of Medical Genetics　Vol. 25　No. 7　p. 100861-100861　2023/07　Research paper (scientific journal)

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype

Tatsuyuki Matsudaira, Sosuke Nakano, Yusuke Konishi, Shimpei Kawamoto, Ken Uemura, Tamae Kondo, Koki Sakurai, Takaaki Ozawa, Takatoshi Hikida, Okiru Komine, Koji Yamanaka, Yuki Fujita, Toshihide Yamashita, Tomonori Matsumoto, Eiji Hara

Communications Biology　Vol. 6　No. 1　2023/06/23　Research paper (scientific journal)

Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker

Hiroshi Tsujioka, Toshihide Yamashita

Frontiers in Cellular Neuroscience　Vol. 17　2023/01/30　Research paper (scientific journal)

CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice

Takeru Furumiya, Takahide Itokazu, Toru Nakanishi, Toshihide Yamashita

Neuroscience Research　2022/12　Research paper (scientific journal)

A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations

Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga, Toshihide Yamashita

Journal of Neuroinflammation　Vol. 19　No. 1　2022/10/27　Research paper (scientific journal)

The effects of Bone Morphogenetic Protein 4 on adult neural stem cell proliferation, differentiation and survival in an in vitro model of ischemic stroke

Ahmed K.M.A. Ahmed, Hiroshi Nakagawa, Toke Jost Isaksen, Toshihide Yamashita

Neuroscience Research　Vol. 183　p. 17-29　2022/07　Research paper (scientific journal)

ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons.

Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E Yull, Timothy S Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakami

The Journal of experimental medicine　Vol. 219　No. 6　2022/06/06　Research paper (scientific journal)

Neuroplasticity related to chronic pain and its modulation by microglia.

Shin-Ichiro Hiraga, Takahide Itokazu, Mariko Nishibe, Toshihide Yamashita

Inflammation and regeneration　Vol. 42　No. 1　p. 15-15　2022/05/03　Research paper (scientific journal)

Single-nucleus RNA sequencing identified cells with ependymal cell-like features enriched in neonatal mice after spinal cord injury.

Iyo Ikeda-Yorifuji, Hiroshi Tsujioka, Yasushi Sakata, Toshihide Yamashita

Neuroscience research　2022/04/20　Research paper (scientific journal)

Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment.

Nao Shibuya, Takahide Itokazu, Tsubasa Ueda, Toshihide Yamashita

Translational stroke research　2022/04/20　Research paper (scientific journal)

RGMa signal in Macrophages Induces Neutrophil-related Astrocytopathy in NMO.

Shosuke Iwamoto, Takahide Itokazu, Atsushi Sasaki, Hirotoshi Kataoka, Shinji Tanaka, Takeshi Hirata, Keiko Miwa, Toshihiko Suenaga, Yoshiki Takai, Tatsuro Misu, Kazuo Fujihara, Toshihide Yamashita

Annals of neurology　2022/02/15　Research paper (scientific journal)

Synaptic and Genetic Bases of Impaired Motor Learning Associated with Modified Experience-Dependent Cortical Plasticity in Heterozygous Reeler Mutants

Mariko Nishibe, Hiroki Toyoda, Shin-ichiro Hiraga, Toshihide Yamashita, Yu Katsuyama

Cerebral Cortex　Vol. 32　No. 3　p. 504-519　2022/01/22　Research paper (scientific journal)

Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice.

Takeshi Hirata, Takahide Itokazu, Atsushi Sasaki, Fuminori Sugihara, Toshihide Yamashita

Frontiers in immunology　Vol. 13　p. 870126-870126　2022　Research paper (scientific journal)

Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury.

Taihei Ninomiya, Hiroshi Nakagawa, Ken-Ichi Inoue, Yukio Nishimura, Takao Oishi, Toshihide Yamashita, Masahiko Takada

Frontiers in neural circuits　Vol. 16　p. 847100-847100　2022　Research paper (scientific journal)

Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.

Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, Yoshihiro Nishikawa, Hozaifa Metwally, Yuzo Kodama, Shinya Tanaka, Hisataka Sabe, Toshihide Yamashita, Shimon Sakaguchi, Tadamitsu Kishimoto, Shigeru Hashimoto

Cancer immunology research　Vol. 9　No. 8　p. 862-876　2021/08　Research paper (scientific journal)

Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice

Hisao Miyajima, Takahide Itokazu, Shogo Tanabe, Toshihide Yamashita

Cell Death & Disease　Vol. 12　No. 8　2021/08　Research paper (scientific journal)

An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury

Hajime Yamanaka, Yu Takata, Hiroshi Nakagawa, Tomoko Isosaka-Yamanaka, Toshihide Yamashita, Masahiko Takada

PLOS ONE　Vol. 16　No. 6　p. e0252023-e0252023　2021/06/02　Research paper (scientific journal)

Protocol for mouse adult neural stem cell isolation and culture

Ahmed K.M.A. Ahmed, Toke Jost Isaksen, Toshihide Yamashita

STAR Protocols　Vol. 2　No. 2　p. 100522-100522　2021/06　Research paper (scientific journal)

Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury

Yuka Honjo, Yuki Fujita, Hitoshi Niwa, Toshihide Yamashita

PLOS ONE　Vol. 16　No. 4　p. e0251013-e0251013　2021/04/29　Research paper (scientific journal)

Neuroprotective function of microglia in the developing brain.

Yuki Fujita, Toshihide Yamashita

Neuronal signaling　Vol. 5　No. 1　2021/04　Research paper (scientific journal)

Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling

Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara, Masaki Takao, Hideki Mochizuki, Akiyoshi Fukamizu, Toshihide Yamashita

Nature Aging　Vol. 1　No. 3　p. 284-294　2021/03　Research paper (scientific journal)

Complement cascade functions during brain development and neurodegeneration.

Oluwaseun Fatoba, Takahide Itokazu, Toshihide Yamashita

The FEBS journal　Vol. 289　No. 8　p. 2085-2109　2021/02/18　Research paper (scientific journal)

Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson's disease.

Wakana Oda, Yuki Fujita, Kousuke Baba, Hideki Mochizuki, Hitoshi Niwa, Toshihide Yamashita

Cell death & disease　Vol. 12　No. 2　p. 181-181　2021/02/15　Research paper (scientific journal)

Mechanisms and significance of microglia-axon interactions in physiological and pathophysiological conditions.

Yuki Fujita, Toshihide Yamashita

Cellular and molecular life sciences : CMLS　2021/01/28　Research paper (scientific journal)

Protocol for Co-culture of Microglia with Axons.

Yuki Fujita, Toshihide Yamashita

STAR protocols　Vol. 1　No. 3　p. 100111-100111　2020/12/18　Research paper (scientific journal)

Proton-sensing receptor GPR132 facilitates migration of astrocytes.

Ken Matoba, Shinya Yamashita, Toke Jost Isaksen, Toshihide Yamashita

Neuroscience research　2020/12/15　Research paper (scientific journal)

Neural circuit repair after central nervous system injury.

Hiroshi Tsujioka, Toshihide Yamashita

International immunology　2020/12/03　Research paper (scientific journal)

Microglia as therapeutic target in central nervous system disorders.

Oluwaseun Fatoba, Takahide Itokazu, Toshihide Yamashita

Journal of pharmacological sciences　Vol. 144　No. 3　p. 102-118　2020/11　Research paper (scientific journal)

Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury.

Naoki Sada, Yuki Fujita, Nanano Mizuta, Masaki Ueno, Takahisa Furukawa, Toshihide Yamashita

Cell death & disease　Vol. 11　No. 8　p. 655-655　2020/08/18　Research paper (scientific journal)

Recent insights into peroxisome biogenesis and associated diseases.

Yukio Fujiki, Yuichi Abe, Yuuta Imoto, Akemi J Tanaka, Kanji Okumoto, Masanori Honsho, Shigehiko Tamura, Non Miyata, Toshihide Yamashita, Wendy K Chung, Tsuneyoshi Kuroiwa

Journal of cell science　Vol. 133　No. 9　2020/05/11　Research paper (scientific journal)

Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis.

Yuki Nakazato, Yuki Fujita, Masamitsu Nakazato, Toshihide Yamashita

Scientific reports　Vol. 10　No. 1　p. 7354-7354　2020/04/30　Research paper (scientific journal)

Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain.

Yuki Fujita, Toru Nakanishi, Masaki Ueno, Shigeyoshi Itohara, Toshihide Yamashita

Cell reports　Vol. 31　No. 4　p. 107580-107580　2020/04/28　Research paper (scientific journal)

A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway.

Yuichi Abe, Masanori Honsho, Ryoko Kawaguchi, Takashi Matsuzaki, Yayoi Ichiki, Masashi Fujitani, Kazushirou Fujiwara, Masaaki Hirokane, Masahide Oku, Yasuyoshi Sakai, Toshihide Yamashita, Yukio Fujiki

The Journal of biological chemistry　Vol. 295　No. 16　p. 5321-5334　2020/04/17　Research paper (scientific journal)

Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.

Toke Jost Isaksen, Yuki Fujita, Toshihide Yamashita

Stem cell reports　Vol. 14　No. 4　p. 677-691　2020/04/14　Research paper (scientific journal)

Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting.

Shin-Ichiro Hiraga, Takahide Itokazu, Maki Hoshiko, Hironobu Takaya, Mariko Nishibe, Toshihide Yamashita

JCI insight　Vol. 5　No. 3　2020/02/13　Research paper (scientific journal)

Proteomic analysis of protein changes in plasma by balloon test occlusion.

Tomohiko Ozaki, Rieko Muramatsu, Hajime Nakamura, Manabu Kinoshita, Haruhiko Kishima, Toshihide Yamashita

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia　Vol. 72　p. 397-401　2020/02　Research paper (scientific journal)

Immunotherapies in Huntington's disease and α-Synucleinopathies.

Oluwaseun Fatoba, Yosuke Ohtake, Takahide Itokazu, Toshihide Yamashita

Frontiers in immunology　Vol. 11　p. 337-337　2020　Research paper (scientific journal)

Repulsive Guidance Molecule A Regulates Adult Neurogenesis Via the Neogenin Receptor.

Toke Jost Isaksen, Toshihide Yamashita

Neuroscience insights　Vol. 15　p. 2633105520948481-2633105520948481　2020　Research paper (scientific journal)

Peroxisome Deficiency Impairs BDNF Signaling and Memory.

Yuichi Abe, Yoshiki Nishimura, Kaori Nakamura, Shigehiko Tamura, Masanori Honsho, Hiroshi Udo, Toshihide Yamashita, Yukio Fujiki

Frontiers in cell and developmental biology　Vol. 8　p. 567017-567017　2020　Research paper (scientific journal)

Alterations in Chromatin Structure and Function in the Microglia.

Yuki Fujita, Toshihide Yamashita

Frontiers in cell and developmental biology　Vol. 8　p. 626541-626541　2020　Research paper (scientific journal)

ペルオキシソーム形成異常による小脳形態形成障害の病態発症機構

阿部 雄一, 本庄 雅則, 伊藤 竜太, 藤谷 昌司, 中山 啓子, 大城 遼平, 中山 敬一, 山下 俊英, 藤木 幸夫

日本生化学会大会プログラム・講演要旨集　Vol. 92回　p. [1T04a-06]　2019/09

Microglia suppress the secondary progression of autoimmune encephalomyelitis.

Shogo Tanabe, Shohei Saitoh, Hisao Miyajima, Takahide Itokazu, Toshihide Yamashita

Glia　Vol. 67　No. 9　p. 1694-1704　2019/09

The effects of leptin on glial cells in neurological diseases.

Fujita, Y, Yamashita, T

Frontiers Neuroscience　Vol. 13　2019/08

Increased expression of fibronectin leucine-rich transmembrane protein 3 in the dorsal root ganglion induces neuropathic pain in rats.

Yamada M, Fujita Y, Hayano Y, Hayakawa H, Baba K, Mochizuki H, Yamashita T

The Journal of neuroscience : the official journal of the Society for Neuroscience　2019/07

Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice.

Tsujioka H, Yamashita T

BMC genomics　Vol. 20　No. 1　2019/07

Neogenin is a Determining Factor for Regenerating Neurons Following Spinal Cord Injury.

Yamashita T

Neuroscience　Vol. 408　p. 448-449　2019/06

Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury.

Nakanishi T, Fujita Y, Tanaka T, Yamashita T

Neuroscience letters　Vol. 709　2019/06

Myeloid-Derived Suppressor Cells Infiltrate the Brain and Suppress Neuroinflammation in a Mouse Model of Focal Traumatic Brain Injury.

Hosomi S, Koyama Y, Watabe T, Ohnishi M, Ogura H, Yamashita T, Shimazu T

Neuroscience　Vol. 406　p. 457-466　2019/05　Research paper (scientific journal)

Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system.

Hamaguchi M, Muramatsu R, Fujimura H, Mochizuki H, Kataoka H, Yamashita T

eLife　Vol. 8　2019/05

Function of Lymphocytes in Oligodendrocyte Development.

Tanabe S, Yamashita T

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry　2019/03

Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications.

Araki T, Yamashita T

Neuroscience research　Vol. 139　p. 1-2　2019/02

Roles of Effector T Cells in Neurological Autoimmunity

Yuki Fujita, Toshihide Yamashita

Contemporary Clinical Neuroscience　p. 63-81　2019　Part of collection (book)

Changes in nerve excitability indices in hereditary transthyretin amyloidosis.

Yamashita T, Ueda M, Misawa S, Inoue Y, Masuda T, Misumi Y, Takamatsu K, Obayashi K, Kuwabara S, Ando Y

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis　Vol. 26　No. sup1　p. 9-10　2019

Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury.

Nakanishi T, Fujita Y, Yamashita T

Cell death & disease　Vol. 10　No. 2　2019/01

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.

Abe Y, Honsho M, Itoh R, Kawaguchi R, Fujitani M, Fujiwara K, Hirokane M, Matsuzaki T, Nakayama K, Ohgi R, Marutani T, Nakayama KI, Yamashita T, Fujiki Y

Life science alliance　Vol. 1　No. 6　p. e201800062-e201800062　2018/12　Research paper (scientific journal)

Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica

Kana Harada, Yuki Fujita, Tatsusada Okuno, Shogo Tanabe, Yoshihisa Koyama, Hideki Mochizuki, Toshihide Yamashita

Scientific Reports　Vol. 8　No. 1　2018/12/01　Research paper (scientific journal)

Inhibiting repulsive guidance molecule A suppresses secondary progression in mouse models of multiple sclerosis.

Tanabe, S, Fujita, Y, Ikuma, K, Yamashita, T

Cell Death & Disease　Vol. 9　No. 11　2018/11

Sirtuins in Neuroendocrine Regulation and Neurological Diseases

Fujita, Y, Yamashita, T

Frontiers Neuroscience　Vol. 12　2018/10

The role of immune cells in brain development and neurodevelopmental diseases.

Tanabe S, Yamashita T

International immunology　Vol. 30　No. 10　p. 437-444　2018/09

B lymphocytes: Crucial contributors to brain development and neurological diseases.

Tanabe S, Yamashita T

Neuroscience research　2018/08

Developmental abnormality contributes to cortex-dependent motor impairments and higher intracortical current requirement in the reeler homozygous mutants

Mariko Nishibe, Yu Katsuyama, Toshihide Yamashita

Brain Structure and Function　Vol. 223　No. 6　p. 2575-2587　2018/07/01　Research paper (scientific journal)

Myotube-derived factor promotes oligodendrocyte precursor cell proliferation

Akino Nakasone, Rieko Muramatsu, Yuki Kato, Yukio Kawahara, Toshihide Yamashita

Biochemical and Biophysical Research Communications　Vol. 500　No. 3　p. 609-613　2018/06/07　Research paper (scientific journal)

Macrophage P2X4 receptors augment bacterial killing and protect against sepsis.

Csóka B, Németh ZH, Szabó I, Davies DL, Varga ZV, Pálóczi J, Falzoni S, Di Virgilio F, Muramatsu R, Yamashita T, Pacher P, Haskó G

JCI insight　Vol. 3　No. 11　2018/06

B-1a lymphocytes promote oligodendrogenesis during brain development

Shogo Tanabe, Toshihide Yamashita

Nature Neuroscience　Vol. 21　No. 4　p. 506-516　2018/04/01　Research paper (scientific journal)

The soluble form of LOTUS inhibits nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor

Yutaka Kawakami, Yuji Kurihara, Yu Saito, Yuki Fujita, Toshihide Yamashita, Kohtaro Takei

Journal of Neuroscience　Vol. 38　No. 10　p. 2589-2604　2018/03/07　Research paper (scientific journal)

An image-based miRNA screen identifies miRNA-135s as regulators of CNS axon growth and regeneration by targeting krüppel-like factor 4

Eljo Y. Van Battum, Marieke G. Verhagen, Vamshidhar R. Yuki Vangoor Fujita, Alwin A. H. A. Derijck, Eoghan O’Duibhir, Giuliano Giuliani, Thijs De Gunst, Youri Adolfs, Daphne Lelieveld, David Egan, Roel Q. J. Schaapveld, Toshihide Yamashita, R. Jeroen Pasterkamp

Journal of Neuroscience　Vol. 38　No. 3　p. 613-630　2018/01/17　Research paper (scientific journal)

Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis.

Lin H, Muramatsu R, Maedera N, Tsunematsu H, Hamaguchi M, Koyama Y, Kuroda M, Ono K, Sawada M, Yamashita T

EBioMedicine　Vol. 27　p. 71-85　2018/01　Research paper (scientific journal)

Inflammatory projections after focal brain injury trigger neuronal network disruption: An ¹⁸F-DPA714 PET study in mice.

Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T

NeuroImage. Clinical　Vol. 20　p. 946-954　2018　Research paper (scientific journal)

Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma.

Fukunaga T, Fujita Y, Kishima H, Yamashita T

PloS one　Vol. 13　No. 11　2018

Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury.

Nakagawa H, Ninomiya T, Yamashita T, Takada M

Cerebral cortex (New York, N.Y. : 1991)　Vol. 29　No. 2　p. 561-572　2018/01　Research paper (scientific journal)

Class i histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury article /13/51 /64/60 /38/77

Suxiang Zhang, Yuki Fujita, Rieko Matsuzaki, Toshihide Yamashita

Cell Death and Disease　Vol. 9　No. 5　2018/01/01　Research paper (scientific journal)

The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain

Yoshitaka Kanemitsu, Masashi Fujitani, Yuki Fujita, Suxiang Zhang, You-Qiang Su, Yukio Kawahara, Toshihide Yamashita

Scientific Reports　Vol. 7　No. 1　2017/12/01　Research paper (scientific journal)

Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis

Masashi Fujitani, Ryohei Sato, Toshihide Yamashita

Scientific Reports　Vol. 7　No. 1　2017/12/01　Research paper (scientific journal)

能動的運動による脳損傷後の機能回復メカニズム

田中 貴士, 山下 俊英

脳科学とリハビリテーション　Vol. 17　p. 49-49　2017/09

Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.

Takafumi Kawai, Yoshifumi Okochi, Tomohiko Ozaki, Yoshio Imura, Schuichi Koizumi, Maya Yamazaki, Manabu Abe, Kenji Sakimura, Toshihide Yamashita, Yasushi Okamura

Journal of neurochemistry　Vol. 142　No. 5　p. 686-699　2017/09　Research paper (scientific journal)

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

K Ishizuka, Y Fujita, T Kawabata, H Kimura, Y Iwayama, T Inada, Y Okahisa, J Egawa, M Usami, I Kushima, Y Uno, T Okada, M Ikeda, B Aleksic, D Mori, To Someya, T Yoshikawa, N Iwata, H Nakamura, T Yamashita, N Ozaki

Translational Psychiatry　Vol. 7　No. 8　p. e1184-e1184　2017/08　Research paper (scientific journal)

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

H Kimura, Y Fujita, T Kawabata, K Ishizuka, C Wang, Y Iwayama, Y Okahisa, I Kushima, M Morikawa, Y Uno, T Okada, M Ikeda, T Inada, A Branko, D Mori, T Yoshikawa, N Iwata, H Nakamura, T Yamashita, N Ozaki

Translational Psychiatry　Vol. 7　No. 8　p. e1214-e1214　2017/08　Research paper (scientific journal)

Spatial organization of genome architecture in neuronal development and disease

Fujita Y, Yamashita T

Neurochemistry International　2017/07

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

Christian Siebold, Toshihide Yamashita, Philippe P. Monnier, Bernhard K. Mueller, R. Jeroen Pasterkamp

TRENDS IN CELL BIOLOGY　Vol. 27　No. 5　p. 365-378　2017/05

Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior

Yuki Fujita, Koji Masuda, Masashige Bando, Ryuichiro Nakato, Yuki Katou, Takashi Tanaka, Masahiro Nakayama, Keizo Takao, Tsuyoshi Miyakawa, Tatsunori Tanaka, Yukio Ago, Hitoshi Hashimoto, Katsuhiko Shirahige, Toshihide Yamashita

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 214　No. 5　p. 1431-1452　2017/05　Research paper (scientific journal)

The roles of RGMa-neogenin signaling in inflammation and angiogenesis.

Fujita Y, Yamashita T

Inflammation and Regeneration　Vol. 37　No. 6　2017/03

A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling

M. Fujitani, S. Zhang, R. Fujiki, Y. Fujihara, T. Yamashita

Molecular Psychiatry　Vol. 22　No. 3　p. 364-374　2017/03/01　Research paper (scientific journal)

脊髄損傷後のリハビリテーションが皮質脊髄路の再編を促すメカニズムの解明

中西 徹, 藤田 幸, 山下 俊英

理学療法学Supplement　Vol. 2016　p. 631-631　2017

Peripherally derived FGF21 promotes remyelination in the central nervous system.

Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, Yamashita T

J Clin Invest　Vol. 127　No. 9　p. 3496-3509　2017　Research paper (scientific journal)

Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation

Mariko Kuroda, Rieko Muramatsu, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 482　No. 4　p. 1160-1164　2017/01　Research paper (scientific journal)

Leptin sustains spontaneous remyelination in the adult central nervous system

Ken Matoba, Rieko Muramatsu, Toshihide Yamashita

SCIENTIFIC REPORTS　Vol. 7　2017/01　Research paper (scientific journal)

Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B

Yasufumi Hayano, Keiko Takasu, Yoshihisa Koyama, Moe Yamada, Koichi Ogawa, Kazuhisa Minami, Toshiyuki Asaki, Kazuhiro Kitada, Satoshi Kuwabara, Toshihide Yamashita

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 213　No. 13　p. 2949-2966　2016/12　Research paper (scientific journal)

サル脊髄損傷後の皮質脊髄路再編メカニズムと運動機能回復について

中川 浩, 二宮 太平, 高田 裕生, 山下 俊英, 高田 昌彦

理学療法学　Vol. 43　No. Suppl.2　p. O-1　2016/10

サル脊髄損傷後の皮質脊髄路再編メカニズムと運動機能回復について

中川 浩, 二宮 太平, 高田 裕生, 山下 俊英, 高田 昌彦

日本基礎理学療法学雑誌　Vol. 20　No. 1　p. 49-49　2016/08

Microglia in central nervous system repair after injury

Xuemei Jin, Toshihide Yamashita

JOURNAL OF BIOCHEMISTRY　Vol. 159　No. 5　p. 491-496　2016/05

The P2X4 receptor is required for neuroprotection via ischemic preconditioning

Tomohiko Ozaki, Rieko Muramatsu, Miwa Sasai, Masahiro Yamamoto, Yoshiaki Kubota, Toshiyuki Fujinaka, Toshiki Yoshimine, Toshihide Yamashita

SCIENTIFIC REPORTS　Vol. 6　2016/05　Research paper (scientific journal)

Erratum: Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis (Biochemical and Biophysical Research Communications (2012) 430:2 (604-609) 10.1016/j.bbrc.2012.11.106)

Ryosuke Fujiki, Akinobu Sato, Katsuhiko Hata, Fumi Tashiro, Noriko Yasuhara, Jun-Ichi Miyazaki, Yoshihiro Yoneda, Masashi Fujitani, Toshihide Yamashita

Biochemical and Biophysical Research Communications　Vol. 472　No. 2　2016/04/01　Research paper (scientific journal)

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.

Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, Yamashita T

Translational psychiatry　Vol. 6　No. 3　2016/03　Research paper (scientific journal)

NME2 associates with PTP sigma to transduce signals from chondroitin sulfate proteoglycans

Hajime Hamasaki, Masashi Fujitani, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 471　No. 4　p. 522-527　2016/03　Research paper (scientific journal)

サル脊髄損傷後の皮質脊髄路再編メカニズムと運動機能回復について

中川 浩, 二宮 太平, 髙田 裕生, 山下 俊英, 高田 昌彦

理学療法学Supplement　Vol. 2015　p. 393-393　2016

Repulsive guidance molecule A suppresses angiogenesis

Kana Harada, Yuki Fujita, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 469　No. 4　p. 993-999　2016/01　Research paper (scientific journal)

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

Susan van Erp, Dianne M. A. van den Heuvel, Yuki Fujita, Ross A. Robinson, Anita J. C. G. M. Hellemons, Youri Adolfs, Eljo Y. Van Battum, Anna M. Blokhuis, Marijn Kuijpers, Jeroen A. A. Demmers, Hakan Hedman, Casper C. Hoogenraad, Christian Siebold, Toshihide Yamashita, R. Jeroen Pasterkamp

DEVELOPMENTAL CELL　Vol. 35　No. 5　p. 537-552　2015/12　Research paper (scientific journal)

Acetylation of NDPK-D Regulates Its Subcellular Localization and Cell Survival

Yuki Fujita, Kei Fujiwara, Shigetake Zenitani, Toshihide Yamashita

PLOS ONE　Vol. 10　No. 10　2015/10　Research paper (scientific journal)

The First Nationwide Survey and Genetic Analyses of Bardet-Biedl Syndrome in Japan

Makito Hirano, Wataru Satake, Kenji Ihara, Ikuya Tsuge, Shuji Kondo, Ken Saida, Hiroyuki Betsui, Kazuhiro Okubo, Hikaru Sakamoto, Shuichi Ueno, Yasushi Ikuno, Ryu Ishihara, Hiromi Iwahashi, Mitsuru Ohishi, Toshiyuki Mano, Toshihide Yamashita, Yutaka Suzuki, Yusaku Nakamura, Susumu Kusunoki, Tatsushi Toda

PLOS ONE　Vol. 10　No. 9　2015/09　Research paper (scientific journal)

A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

Yasunobu Arima, Daisuke Kamimura, Toru Atsumi, Masaya Harada, Tadafumi Kawamoto, Naoki Nishikawa, Andrea Stofkova, Takuto Ohki, Kotaro Higuchi, Yuji Morimoto, Peter Wieghofer, Yuka Okada, Yuki Mori, Saburo Sakoda, Shizuya Saika, Yoshichika Yoshioka, Issei Komuro, Toshihide Yamashita, Toshio Hirano, Marco Prinz, Masaaki Murakami

ELIFE　Vol. 4　2015/08　Research paper (scientific journal)

Erratum: Ecto-domain phosphorylation promotes functional recovery from spinal cord injury(Scientific Reports 4(4972) 10.1038/srep04972)

Kenji Suehiro, Yuka Nakamura, Shuai Xu, Youichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita, Yoshinori Takei

Scientific Reports　Vol. 5　2015/07/01　Research paper (scientific journal)

Ecto-domain phosphorylation promotes functional recovery from spinal cord injury (vol 4, 4972, 2014)

Kenji Suehiro, Yuka Nakamura, Shuai Xu, Youichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita, Yoshinori Takei

SCIENTIFIC REPORTS　Vol. 5　2015/07

Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques

Hiroshi Nakagawa, Taihei Ninomiya, Toshihide Yamashita, Masahiko Takada

SCIENTIFIC REPORTS　Vol. 5　2015/07　Research paper (scientific journal)

Prostacyclin Prevents Pericyte Loss and Demyelination Induced by Lysophosphatidylcholine in the Central Nervous System

Rieko Muramatsu, Mariko Kuroda, Ken Matoba, Hsiaoyun Lin, Chisato Takahashi, Yoshihisa Koyama, Toshihide Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 18　p. 11515-11525　2015/05　Research paper (scientific journal)

Regeneration and Protection of the Injured Central Nervous System by Targeting Axon Growth Inhibitors

Yamashita Toshihide

JANOS　Vol. 32　No. 3　p. 255-262　2015

Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury

S. Miyake, R. Muramatsu, M. Hamaguchi, T. Yamashita

Cell Death and Disease　Vol. 6　No. 2　2015/01/01　Research paper (scientific journal)

Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling

Satoko Sumimoto, Rieko Muramatsu, Toshihide Yamashita

BRAIN RESEARCH　Vol. 1594　p. 46-51　2015/01　Research paper (scientific journal)

Down-Regulation of KCC2 Expression and Phosphorylation in Motoneurons, and Increases the Number of in Primary Afferent Projections to Motoneurons in Mice with Post-Stroke Spasticity

Takuya Toda, Kazuto Ishida, Hiroshi Kiyama, Toshihide Yamashita, Sachiko Lee

PLOS ONE　Vol. 9　No. 12　2014/12　Research paper (scientific journal)

Repulsive Guidance Molecule-a Is Involved in Th17-Cell-Induced Neurodegeneration in Autoimmune Encephalomyelitis

Shogo Tanabe, Toshihide Yamashita

CELL REPORTS　Vol. 9　No. 4　p. 1459-1470　2014/11　Research paper (scientific journal)

PEX14欠損マウスにおける大脳皮質の形態とリン脂質の解析

阿部 雄一, 伊藤 竜太, 中山 啓子, 丸谷 寿裕, 本庄 雅則, 藤谷 昌司, 山下 俊英, 中山 敬一, 藤木 幸夫

日本生化学会大会プログラム・講演要旨集　Vol. 87回　p. [3T14a-05]　2014/10

Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion

Yasufumi Hayano, Kensuke Sasaki, Nami Ohmura, Makoto Takemoto, Yurie Maeda, Toshihide Yamashita, Yoshio Hata, Kazuhiro Kitada, Nobuhiko Yamamoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 42　p. 15226-15231　2014/10　Research paper (scientific journal)

Bidirectional tuning of microglia in the developing brain: from neurogenesis to neural circuit formation

Masaki Ueno, Toshihide Yamashita

CURRENT OPINION IN NEUROBIOLOGY　Vol. 27　p. 8-15　2014/08　Research paper (scientific journal)

A selector orchestrates cortical function

Masaki Ueno, Ryosuke Fujiki, Toshihide Yamashita

NATURE NEUROSCIENCE　Vol. 17　No. 8　p. 1016-1017　2014/08

The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex

Suxiang Zhang, Yoshitaka Kanemitsu, Masashi Fujitani, Toshihide Yamashita

SCIENTIFIC REPORTS　Vol. 4　2014/08　Research paper (scientific journal)

Vascular endothelial cells promote cortical neurite outgrowth via an integrin beta 3-dependent mechanism

Satoko Sumimoto, Rieko Muramatsu, Sakiko Fujii, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 450　No. 1　p. 593-597　2014/07　Research paper (scientific journal)

Microglia

Yuki Fujita, Toshihide Yamashita

Neuroprotection and Neuroregeneration for Retinal Diseases　p. 175-187　2014/05/01　Part of collection (book)

Ecto-domain phosphorylation promotes functional recovery from spinal cord injury

Kenji Suehiro, Yuka Nakamura, Shuai Xu, Youichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita, Yoshinori Takei

SCIENTIFIC REPORTS　Vol. 4　2014/05　Research paper (scientific journal)

Pericyte function in the physiological central nervous system

Rieko Muramatsu, Toshihide Yamashita

NEUROSCIENCE RESEARCH　Vol. 81-82　p. 38-41　2014/04　Research paper (scientific journal)

Role of DAPK in neuronal cell death

Yuki Fujita, Toshihide Yamashita

APOPTOSIS　Vol. 19　No. 2　p. 339-345　2014/02　Research paper (scientific journal)

Involvement of Wnt/beta-catenin signaling in the development of neuropathic pain

Takahide Itokazu, Yasufumi Hayano, Ryosuke Takahashi, Toshihide Yamashita

NEUROSCIENCE RESEARCH　Vol. 79　p. 34-40　2014/02　Research paper (scientific journal)

Weakened rate-dependent depression of Hoffmann's reflex and increased motoneuron hyperactivity after motor cortical infarction in mice

S. Lee, T. Toda, H. Kiyama, T. Yamashita

CELL DEATH & DISEASE　Vol. 5　2014/01　Research paper (scientific journal)

The functions and signaling pathways induced by the interactions of APP–related molecules with p75NTR.

Fujita Y, Yamashita T

Receptors & Clinical Investigation　Vol. 1　p. 299-303　2014

Effect of the Sigma-1 receptor on neurite outgrowth

Kimura Y, Fujita Y, Yamashita T

Receptors & Clinical Investigation　Vol. 1　p. 8-12　2014

Concept and molecular basis of axonal regeneration after central nervous system injury

Rieko Muramatsu, Toshihide Yamashita

NEUROSCIENCE RESEARCH　Vol. 78　p. 45-49　2014/01

Axon growth inhibition by RhoA/ROCK in the central nervous system.

Fujita Y, Yamashita T

Frontiers in neuroscience　Vol. 8　2014

Sigma-1 Receptor Enhances Neurite Elongation of Cerebellar Granule Neurons via TrkB Signaling

Yuriko Kimura, Yuki Fujita, Kumi Shibata, Megumi Mori, Toshihide Yamashita

PLoS ONE　Vol. 8　No. 10　2013/10/08　Research paper (scientific journal)

Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination

C. Takahashi, R. Muramatsu, H. Fujimura, H. Mochizuki, T. Yamashita

Cell Death and Disease　Vol. 4　No. 9　2013/09　Research paper (scientific journal)

Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation

Y. Fujita, A. Sato, T. Yamashita

Cell Death and Disease　Vol. 4　No. 8　2013/08　Research paper (scientific journal)

Repulsive guidance molecule a regulates hippocampal mossy fiber branching in vitro

Kazuki Shibata, Soichiro Nakahara, Emi Shimizu, Toshihide Yamashita, Norio Matsuki, Ryuta Koyama

NEUROREPORT　Vol. 24　No. 11　p. 609-615　2013/08　Research paper (scientific journal)

Ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

H. Ishii, S. Tanabe, M. Ueno, T. Kubo, H. Kayama, S. Serada, M. Fujimoto, K. Takeda, T. Naka, T. Yamashita

Cell Death and Disease　Vol. 4　No. 7　2013/07　Research paper (scientific journal)

A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons

R. Fujiki, A. Sato, M. Fujitani, T. Yamashita

Cell Death and Disease　Vol. 4　No. 6　2013/06　Research paper (scientific journal)

Inhibition of Rac1 promotes BMP-2-induced osteoblastic differentiation.

Onishi M, Fujita Y, Yoshikawa H, Yamashita T

Cell death & disease　Vol. 4　2013/06

Layer v cortical neurons require microglial support for survival during postnatal development

Masaki Ueno, Yuki Fujita, Tatsuhide Tanaka, Yuka Nakamura, Junichi Kikuta, Masaru Ishii, Toshihide Yamashita

Nature Neuroscience　Vol. 16　No. 5　p. 543-551　2013/05　Research paper (scientific journal)

Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury

T. Tanaka, Y. Fujita, M. Ueno, L. D. Shultz, T. Yamashita

Cell Death and Disease　Vol. 4　No. 4　2013/04　Research paper (scientific journal)

Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice

H. Nakagawa, M. Ueno, T. Itokazu, T. Yamashita

Cell Death and Disease　Vol. 4　No. 3　2013/03　Research paper (scientific journal)

Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis

Ryosuke Fujiki, Akinobu Sato, Katsuhiko Hata, Fumi Tashiro, Noriko Yasuhara, Jun-ichi Miyazaki, Yoshihiro Yoneda, Masashi Fujitani, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 430　No. 2　p. 604-609　2013/01　Research paper (scientific journal)

Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth.

Noriko Hasebe, Yuki Fujita, Masaki Ueno, Kazuhiro Yoshimura, Yuji Fujino, Toshihide Yamashita

PloS one　Vol. 8　No. 12　2013

Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin

Rieko Muramatsu, Chisato Takahashi, Shuzo Miyake, Harutoshi Fujimura, Hideki Mochizuki, Toshihide Yamashita

NATURE MEDICINE　Vol. 18　No. 11　p. 1658-+　2012/11　Research paper (scientific journal)

[Multiple sclerosis: new drugs and their molecular targets].

Takahide Itokazu, Toshihide Yamashita, Ryosuke Takahashi

Nihon rinsho. Japanese journal of clinical medicine　Vol. 70 Suppl 8　p. 609-12　2012/11　Research paper (scientific journal)

Glucocorticoid Suppresses Dendritic Spine Development Mediated by Down-Regulation of Caldesmon Expression

Daisuke Tanokashira, Tsuyoshi Morita, Ken'ichiro Hayashi, Taira Mayanagi, Kentaro Fukumoto, Yoshiko Kubota, Toshihide Yamashita, Kenji Sobue

JOURNAL OF NEUROSCIENCE　Vol. 32　No. 42　p. 14583-14591　2012/10　Research paper (scientific journal)

Repulsive Guidance Molecule-a and Demyelination: Implications for Multiple Sclerosis

Takekazu Kubo, Shigeru Tokita, Toshihide Yamashita

JOURNAL OF NEUROIMMUNE PHARMACOLOGY　Vol. 7　No. 3　p. 524-528　2012/09

Characterizing the neurite outgrowth inhibitory effect of Mani

Manisha Mishra, Sachiko Lee, Michelle K. Lin, Toshihide Yamashita, Klaus Heese

FEBS LETTERS　Vol. 586　No. 19　p. 3018-3023　2012/09　Research paper (scientific journal)

Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury

H. Ishii, X. Jin, M. Ueno, S. Tanabe, T. Kubo, S. Serada, T. Naka, T. Yamashita

Cell Death and Disease　Vol. 3　No. 8　2012/08　Research paper (scientific journal)

Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice

Xuemei Jin, Hiroshi Ishii, Zhongbin Bai, Takahide Itokazu, Toshihide Yamashita

PLOS ONE　Vol. 7　No. 7　2012/07　Research paper (scientific journal)

脳損傷後の皮質脊髄路再編成におけるSHP-1シグナル抑制の効果

田中 貴士, 藤田 幸, 上野 将紀, 山下 俊英

理学療法学　Vol. 39　No. Suppl.2　p. 0460-0460　2012/04

Chondroitin Sulfate Proteoglycans Down-regulate Spine Formation in Cortical Neurons by Targeting Tropomyosin-related Kinase B (TrkB) Protein

Dai Kurihara, Toshihide Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 287　No. 17　p. 13822-13828　2012/04　Research paper (scientific journal)

Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury

Masaki Ueno, Yasufumi Hayano, Hiroshi Nakagawa, Toshihide Yamashita

BRAIN　Vol. 135　No. Pt 4　p. 1253-1267　2012/04　Research paper (scientific journal)

Identification of the Neogenin-Binding Site on the Repulsive Guidance Molecule A

Takahide Itokazu, Yuki Fujita, Ryosuke Takahashi, Toshihide Yamashita

PLOS ONE　Vol. 7　No. 3　2012/03　Research paper (scientific journal)

脳損傷後の皮質脊髄路再編成におけるSHP-1シグナル抑制の効果

田中 貴士, 藤田 幸, 上野 将紀, 山下 俊英

理学療法学Supplement　Vol. 2011　p. Ab0460-Ab0460　2012

c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice.

Kazuhiro Yoshimura, Masaki Ueno, Sachiko Lee, Yuka Nakamura, Akinobu Sato, Koichi Yoshimura, Haruhiko Kishima, Toshiki Yoshimine, Toshihide Yamashita

Neuroscience research　Vol. 71　No. 3　p. 266-77　2011/11　Research paper (scientific journal)

RhoA Activation and Effect of Rho-kinase Inhibitor in the Development of Retinal Neovascularization in a Mouse Model of Oxygen-induced Retinopathy

Xiaoyun Fang, Masaki Ueno, Toshihide Yamashita, Yasushi Ikuno

CURRENT EYE RESEARCH　Vol. 36　No. 11　p. 1028-1036　2011/11　Research paper (scientific journal)

Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury

Shiro Imagama, Kazuma Sakamoto, Ryoji Tauchi, Ryuichi Shinjo, Tomohiro Ohgomori, Zenya Ito, Haoqian Zhang, Yoshihiro Nishida, Nagamasa Asami, Sawako Takeshita, Nobuo Sugiura, Hideto Watanabe, Toshihide Yamashita, Naoki Ishiguro, Yukihiro Matsuyama, Kenji Kadomatsu

JOURNAL OF NEUROSCIENCE　Vol. 31　No. 47　p. 17091-17102　2011/11　Research paper (scientific journal)

The p75 receptor mediates axon growth inhibition through an association with PIR-B

Y. Fujita, R. Takashima, S. Endo, T. Takai, T. Yamashita

Cell Death and Disease　Vol. 2　No. 9　2011/09　Research paper (scientific journal)

TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule

Yusuke Okamura, Eiji Kohmura, Toshihide Yamashita

NEUROSCIENCE RESEARCH　Vol. 71　No. 1　p. 63-70　2011/09　Research paper (scientific journal)

miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression

Rikako Sanuki, Akishi Onishi, Chieko Koike, Rieko Muramatsu, Satoshi Watanabe, Yuki Muranishi, Shoichi Irie, Shinji Uneo, Toshiyuki Koyasu, Ryosuke Matsui, Yoan Cherasse, Yoshihiro Urade, Dai Watanabe, Mineo Kondo, Toshihide Yamashita, Takahisa Furukawa

NATURE NEUROSCIENCE　Vol. 14　No. 9　p. 1125-U177　2011/09　Research paper (scientific journal)

Activated Microglia Inhibit Axonal Growth through RGMa

Mari Kitayama, Masaki Ueno, Toru Itakura, Toshihide Yamashita

PLOS ONE　Vol. 6　No. 9　2011/09　Research paper (scientific journal)

Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice

Masaki Ueno, Toshihide Yamashita

EXPERIMENTAL NEUROLOGY　Vol. 230　No. 2　p. 280-290　2011/08　Research paper (scientific journal)

FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons

Satoru Yamagishi, Falko Hampel, Katsuhiko Hata, Daniel del Toro, Manuela Schwark, Elena Kvachnina, Martin Bastmeyer, Toshihide Yamashita, Victor Tarabykin, Ruediger Klein, Joaquim Egea

EMBO JOURNAL　Vol. 30　No. 14　p. 2920-2933　2011/07　Research paper (scientific journal)

Axotomy induces axonogenesis in hippocampal neurons through STAT3.

Ohara R, Fujita Y, Hata K, Nakagawa M, Yamashita T

Cell death & disease　Vol. 2　2011/06

Suppression of phagocytic cells in retinal disorders using amphiphilic poly (gamma-glutamic acid) nanoparticles containing dexamethasone

Morin Ryu, Toru Nakazawa, Takami Akagi, Tatsuhide Tanaka, Ryou Watanabe, Masayuki Yasuda, Noriko Himori, Kazuichi Maruyama, Toshihide Yamashita, Toshiaki Abe, Mitsuru Akashi, Kohji Nishida

JOURNAL OF CONTROLLED RELEASE　Vol. 151　No. 1　p. 65-73　2011/04　Research paper (scientific journal)

Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity

Yuki Fujita, Shota Endo, Toshiyuki Takai, Toshihide Yamashita

EMBO JOURNAL　Vol. 30　No. 7　p. 1389-1401　2011/04　Research paper (scientific journal)

RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

Rieko Muramatsu, Takekazu Kubo, Masahiro Mori, Yuka Nakamura, Yuki Fujita, Tsugio Akutsu, Tatsusada Okuno, Junko Taniguchi, Atsushi Kumanogoh, Mari Yoshida, Hideki Mochizuki, Satoshi Kuwabara, Toshihide Yamashita

NATURE MEDICINE　Vol. 17　No. 4　p. 488-U129　2011/04　Research paper (scientific journal)

Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of gamma-aminobutyric acid signaling

S. Lee, M. Ueno, T. Yamashita

CELL DEATH & DISEASE　Vol. 2　2011/03　Research paper (scientific journal)

Corticospinal tract fibers cross the ephrin-B3-negative part of the midline of the spinal cord after brain injury

Shusaku Omoto, Masaki Ueno, Soichiro Mochio, Toshihide Yamashita

NEUROSCIENCE RESEARCH　Vol. 69　No. 3　p. 187-195　2011/03　Research paper (scientific journal)

Neogenin, a Receptor for Bone Morphogenetic Proteins

Meiko Hagihara, Mitsuharu Endo, Katsuhiko Hata, Chikahisa Higuchi, Kunio Takaoka, Hideki Yoshikawa, Toshihide Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 7　p. 5157-5165　2011/02　Research paper (scientific journal)

Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin beta

Ryo Ohara, Katsuhiko Hata, Noriko Yasuhara, Rashid Mehmood, Yoshihiro Yoneda, Masanori Nakagawa, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 405　No. 4　p. 697-702　2011/02　Research paper (scientific journal)

Abnormal cystatin C levels in two patients with bardet-biedl syndrome

Makito Hirano, Mitsuru Ohishi, Toshihide Yamashita, Yasushi Ikuno, Hiromi Iwahashi, Toshiyuki Mano, Ryu Ishihara, Ichiro Tanaka, Keiko Yanagihara, Chiharu Isono, Hikaru Sakamoto, Yusaku Nakamura, Susumu Kusunoki

Clinical Medicine Insights: Case Reports　Vol. 4　p. 17-20　2011　Research paper (scientific journal)

Paired Immunoglobulin-like Receptor B Knockout Does Not Enhance Axonal Regeneration or Locomotor Recovery after Spinal Cord Injury

Yuka Nakamura, Yuki Fujita, Masaki Ueno, Toshiyuki Takai, Toshihide Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 3　p. 1876-1883　2011/01　Research paper (scientific journal)

Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins

Hiroshi Ishii, Takekazu Kubo, Atsushi Kumanogoh, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 402　No. 1　p. 168-172　2010/11　Research paper (scientific journal)

Genetic Deletion of Paired Immunoglobulin-Like Receptor B Does Not Promote Axonal Plasticity or Functional Recovery after Traumatic Brain Injury

Shusaku Omoto, Masaki Ueno, Soichiro Mochio, Toshiyuki Takai, Toshihide Yamashita

JOURNAL OF NEUROSCIENCE　Vol. 30　No. 39　p. 13045-13052　2010/09　Research paper (scientific journal)

神経因性疼痛に関する薬物療法の基礎研究 炎症性・神経因性疼痛に対するβエンドルフィン前駆体(プロオピオメラノコルチン)の遺伝子導入による治療効果

山下 正臣, 石川 哲大, 大鳥 精司, 山内 かづ代, 鈴木 宗貴, 江口 和, 折田 純久, 遠藤 光晴, 山下 俊英, 高橋 和久

日本整形外科学会雑誌　Vol. 84　No. 8　p. S1203-S1203　2010/08

Paired immunoglobulin-like receptor B(PirB)ノックアウトマウスにおける外傷性脳損傷後の運動機能回復および神経可塑性(Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury)

大本 周作, 上野 将紀, 持尾 聰一郎, 高井 俊行, 山下 俊英

神経化学　Vol. 49　No. 2-3　p. 628-628　2010/08

Olfactory Mucosal Transplantation After Spinal Cord Injury Improves Voiding Efficiency by Suppressing Detrusor-Sphincter Dyssynergia in Rats

Jiro Nakayama, Tetsuya Takao, Hiroshi Kiuchi, Keisuke Yamamoto, Shinichiro Fukuhara, Yasushi Miyagawa, Masanori Aoki, Koichi Iwatsuki, Toshiki Yoshimine, Masaki Ueno, Toshihide Yamashita, Norio Nonomura, Akira Tsujimura, Akihiko Okuyama

JOURNAL OF UROLOGY　Vol. 184　No. 2　p. 775-782　2010/08　Research paper (scientific journal)

Reduction of Brain beta-Amyloid (A beta) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and A beta Clearance

Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, Ryuichi Morishita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 29　p. 22091-22102　2010/07　Research paper (scientific journal)

Solitary intradural extramedullary lymphoma of the cervical spine.

Yamashita T, Sakaura H, Oshima K, Iwasaki M, Yoshikawa H

Journal of neurosurgery. Spine　Vol. 12　No. 4　p. 436-439　2010/04

N-Acetylglucosamine 6-O-Sulfotransferase-1-Deficient Mice Show Better Functional Recovery after Spinal Cord Injury

Zenya Ito, Kazuma Sakamoto, Shiro Imagama, Yukihiro Matsuyama, Haoqian Zhang, Kenichi Hirano, Kei Ando, Toshihide Yamashita, Naoki Ishiguro, Kenji Kadomatsu

JOURNAL OF NEUROSCIENCE　Vol. 30　No. 17　p. 5937-5947　2010/04　Research paper (scientific journal)

Expression of galectin-1 in immune cells and glial cells after spinal cord injury

Dai Kurihara, Masaki Ueno, Tatsuhide Tanaka, Toshihide Yamashita

NEUROSCIENCE RESEARCH　Vol. 66　No. 3　p. 265-270　2010/03　Research paper (scientific journal)

Limited functional recovery in rats with complete spinal cord injury after transplantation of whole-layer olfactory mucosa: laboratory investigation.

Masanori Aoki, Haruhiko Kishima, Kazuhiro Yoshimura, Masahiro Ishihara, Masaki Ueno, Katsuhiko Hata, Toshihide Yamashita, Koichi Iwatsuki, Toshiki Yoshimine

Journal of neurosurgery. Spine　Vol. 12　No. 2　p. 122-30　2010/02　Research paper (scientific journal)

Inhibition of TGF-beta1 promotes functional recovery after spinal cord injury.

Masaaki Kohta, Eiji Kohmura, Toshihide Yamashita

Neuroscience research　Vol. 65　No. 4　p. 393-401　2009/12

Chronic Inflammatory Demyelinating Polyneuropathy Sera Inhibit Axonal Growth of Mouse Dorsal Root Ganglion Neurons by Activation of Rho-Kinase

Junko Taniguchi, Setsu Sawai, Masahiro Mori, Takekazu Kubo, Kazuaki Kanai, Sonoko Misawa, Sagiri Isose, Toshihide Yamashita, Satoshi Kuwabara

ANNALS OF NEUROLOGY　Vol. 66　No. 5　p. 694-697　2009/11　Research paper (scientific journal)

Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation

Takeo Furuya, Masayuki Hashimoto, Masao Koda, Akihiko Okawa, Atsushi Murata, Kazuhisa Takahashi, Toshihide Yamashita, Masashi Yamazaki

BRAIN RESEARCH　Vol. 1295　p. 192-202　2009/10　Research paper (scientific journal)

Nerve Growth Factor of Cultured Medium Extracted From Human Degenerative Nucleus Pulposus Promotes Sensory Nerve Growth and Induces Substance P In Vitro

Kazuyo Yamauchi, Gen Inoue, Takana Koshi, Masaomi Yamashita, Toshinori Ito, Munetaka Suzuki, Yawara Eguchi, Sumihisa Orita, Masashi Takaso, Koichi Nakagawa, Yasuchika Aoki, Nobuyasu Ochiai, Shunji Kishida, Mitsuharu Endo, Toshihide Yamashita, Kazuhisa Takahashi, Seiji Ohtori

SPINE　Vol. 34　No. 21　p. 2263-2269　2009/10　Research paper (scientific journal)

Transfection of Rat Cells With Proopiomeranocortin Gene, Precursor of Endogenous Endorphin, Using Radial Shock Waves Suppresses Inflammatory Pain

Masaomi Yamashita, Kazuyo Yamauchi, Munetaka Suzuki, Yawara Eguchi, Sumihisa Orita, Mitsuharu Endo, Toshihide Yamashita, Kazuhisa Takahashi, Seiji Ohtori

SPINE　Vol. 34　No. 21　p. 2270-2277　2009/10　Research paper (scientific journal)

TNF-alpha contributes to axonal sprouting and functional recovery following traumatic brain injury

Taku Oshima, Sachiko Lee, Akinobu Sato, Shigeto Oda, Hiroyuki Hirasawa, Toshihide Yamashita

BRAIN RESEARCH　Vol. 1290　p. 102-110　2009/09　Research paper (scientific journal)

Engulfment of Axon Debris by Microglia Requires p38 MAPK Activity

Tatsuhide Tanaka, Masaki Ueno, Toshihide Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 32　p. 21626-21636　2009/08　Research paper (scientific journal)

βエンドルフィンの前駆体(POMC)遺伝子の体外衝撃波による遺伝子導入はアジュバント由来の疼痛を抑制する

山下 正臣, 大鳥 精司, 山内 かづ代, 鈴木 宗貴, 江口 和, 折田 純久, 遠藤 光晴, 山下 俊英, 高橋 和久

PAIN RESEARCH　Vol. 24　No. 2　p. 80-80　2009/07

Wnt-Ryk Signaling Mediates Axon Growth Inhibition and Limits Functional Recovery after Spinal Cord Injury

Tomohiro Miyashita, Masao Koda, Keiko Kitajo, Masashi Yamazaki, Kazuhisa Takahashi, Akira Kikuchi, Toshihide Yamashita

JOURNAL OF NEUROTRAUMA　Vol. 26　No. 7　p. 955-964　2009/07　Research paper (scientific journal)

Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase

Noriko Uesugi, Rieko Muramatsu, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 383　No. 4　p. 509-512　2009/06　Research paper (scientific journal)

Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury

Xiaoxiang Liu, Motonori Hashimoto, Hajime Horii, Atsushi Yamaguchi, Koji Naito, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 382　No. 4　p. 795-800　2009/05　Research paper (scientific journal)

Inactivation of Ras by p120GAP via Focal Adhesion Kinase Dephosphorylation Mediates RGMa-Induced Growth Cone Collapse

Mitsuharu Endo, Toshihide Yamashita

JOURNAL OF NEUROSCIENCE　Vol. 29　No. 20　p. 6649-6662　2009/05　Research paper (scientific journal)

Unc5B associates with LARG to mediate the action of repulsive guidance molecule

Katsuhiko Hata, Kozo Kaibuchi, Shinobu Inagaki, Toshihide Yamashita

JOURNAL OF CELL BIOLOGY　Vol. 184　No. 5　p. 737-750　2009/03　Research paper (scientific journal)

Molecular mechanism underlying the inhibition of axonal regeneration after CNS injury

Rieko Muramatsu, Toshihide Yamashita

Neurochemistry: Molecular Aspects, Cellular Aspects and Clinical Applications　p. 247-250　2009　Part of collection (book)

Zyxin is a novel interacting partner for SIRT1

Yuki Fujita, Atsushi Yamaguchi, Katsuhiko Hata, Mitsuharu Endo, Naoto Yamaguchi, Toshihide Yamashita

BMC CELL BIOLOGY　Vol. 10　2009/01　Research paper (scientific journal)

Intrinsic regenerative mechanisms of central nervous system neurons

Rieko Muramatsu, Masaki Ueno, Toshihide Yamashita

BIOSCIENCE TRENDS　Vol. 3　No. 5　p. 179-183　2009

The p75 Receptor Is Associated With Inflammatory Thermal Hypersensitivity

Tomoko Watanabe, Toshinori Ito, Gen Inoue, Seiji Ohtori, Keiko Kitajo, Hideo Doya, Kazuhisa Takahashi, Toshihide Yamashita

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 86　No. 16　p. 3566-3574　2008/12　Research paper (scientific journal)

Inhibition of a eukaryotic initiation factor (eIF2B delta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans

Daisuke Tohyama, Atsushi Yamaguchi, Toshihide Yamashita

FASEB JOURNAL　Vol. 22　No. 12　p. 4327-4337　2008/12　Research paper (scientific journal)

Neogenin regulates neuronal survival through DAP kinase.

Fujita Y, Taniguchi J, Uchikawa M, Endo M, Hata K, Kubo T, Mueller BK, Yamashita T

Cell death and differentiation　Vol. 15　No. 10　p. 1593-1608　2008/10　Research paper (scientific journal)

LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin

Gregor Schaffar, Junko Taniguchi, Tanja Brodbeck, Axel H. Meyer, Martin Schmidt, Toshihide Yamashita, Bernhard K. Mueller

JOURNAL OF NEUROCHEMISTRY　Vol. 107　No. 2　p. 418-431　2008/10　Research paper (scientific journal)

Role of RhoA in activity-dependent cortical axon branching

Soichiro Ohnami, Mitsuharu Endo, Satoshi Hirai, Naofumi Uesaka, Yumiko Hatanaka, Toshihide Yamashita, Nobuhiko Yamamoto

JOURNAL OF NEUROSCIENCE　Vol. 28　No. 37　p. 9117-9121　2008/09　Research paper (scientific journal)

neogeninの細胞死誘導の分子メカニズム(The mechanism of neogenin induced neuronal cell death)

藤田 幸, 谷口 順子, 内川 昌則, 遠藤 光晴, 羽田 克彦, 久保 武一, 山下 俊英

神経化学　Vol. 47　No. 2-3　p. 227-227　2008/08

Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons

Junko Yoshida, Takekazu Kubo, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 372　No. 4　p. 725-729　2008/08　Research paper (scientific journal)

Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1 alpha

Yoichi Ohshima, Takekazu Kubo, Ryuta Koyama, Masaki Ueno, Masanori Nakagawa, Toshihide Yamashita

JOURNAL OF NEUROSCIENCE　Vol. 28　No. 33　p. 8344-8353　2008/08　Research paper (scientific journal)

Peptides derived from repulsive guidance molecule act as antagonists

Masayoshi Suda, Katsuhiko Hata, Aika Sawada, Yuka Nakamura, Takekazu Kubo, Atsushi Yamaguchi, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 371　No. 3　p. 501-504　2008/07　Research paper (scientific journal)

Strategies for regenerating injured axons after spinal cord injury - insights from brain development.

Ueno M, Yamashita T

Biologics : targets & therapy　Vol. 2　No. 2　p. 253-264　2008/06

The therapeutic effects of Rho-ROCK inhibitors on CNS disorders.

Kubo T, Yamaguchi A, Iwata N, Yamashita T

Therapeutics and clinical risk management　Vol. 4　No. 3　p. 605-615　2008/06

BMP inhibition enhances axonal growth and functional recovery after spinal cord injury

Iichiro Matsuura, Junko Taniguchi, Katsuhiko Hata, Naokatsu Saeki, Toshihide Yamashita

JOURNAL OF NEUROCHEMISTRY　Vol. 105　No. 4　p. 1471-1479　2008/05　Research paper (scientific journal)

Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule

Takekazu Kubo, Mitsuharu Endo, Katsuhiko Hata, Junko Taniguchi, Keiko Kitajo, Sayaka Tomura, Atsushi Yamaguchi, Bernhard K. Mueller, Toshihide Yamashita

JOURNAL OF NEUROCHEMISTRY　Vol. 105　No. 1　p. 113-126　2008/04　Research paper (scientific journal)

[Axon growth inhibition signals and strategies to treat injuries to the central nervous system].

Yamashita T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 53　No. 4 Suppl　p. 406-410　2008/03

Rap1 is involved in the signal transduction of myelin-associated glycoprotein.

Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T

Cell death and differentiation　Vol. 15　No. 2　p. 408-419　2008/02　Research paper (scientific journal)

Temperature dependence of the flexural rigidity of single microtubules

Kenji Kawaguchi, Shin'ichi Ishiwata, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 366　No. 3　p. 637-642　2008/02　Research paper (scientific journal)

Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury

Akihiro Kyoto, Katsuhiko Hata, Toshihide Yamashita

BRAIN RESEARCH　Vol. 1186　p. 74-86　2007/12　Research paper (scientific journal)

[Molecular mechanism and regulation of axon growth inhibition]

Yamashita T

Brain and nerve = Shinkei kenkyu no shinpo　Vol. 59　No. 12　p. 1347-1353　2007/12

Rho-ROCK inhibitors for the treatment of CNS injury

Takekazu Kubo, Toshihide Yamashita

Recent Patents on CNS Drug Discovery　Vol. 2　No. 3　p. 173-179　2007/11

BMP inhibits neurite growth by a mechanism dependent on LIM-kinase

Iichiro Matsuura, Mitsuharu Endo, Katsuhiko Hata, Takekazu Kubo, Atsushi Yamaguchi, Naokatsu Saeki, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 360　No. 4　p. 868-873　2007/09　Research paper (scientific journal)

Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis

Toshinori Ito, Seiji Ohtori, Katsuhiko Hata, Gen Inoue, Hideshige Moriya, Kazuhisa Takahashi, Toshihide Yamashita

SPINE　Vol. 32　No. 19　p. 2070-2075　2007/09　Research paper (scientific journal)

培養細胞系を用いたヒト変性椎間板の疼痛伝達機序に関する検討

山内 かづ代, 大鳥 精司, 遠藤 光晴, 中川 晃一, 高橋 和久, 山下 俊英

日本整形外科学会雑誌　Vol. 81　No. 8　p. S999-S999　2007/08

Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway

Meika Kaneko, Takekazu Kubo, Katsuhiko Hata, Atsushi Yamaguchi, Toshihide Yamashita

NEUROSCIENCE LETTERS　Vol. 423　No. 1　p. 62-67　2007/08　Research paper (scientific journal)

培養細胞系を用いたヒト変性椎間板の疼痛伝達機序に関する検討

山内 かづ代, 大鳥 精司, 中川 晃一, 遠藤 光晴, 荒井 桃子, 高橋 和久, 山下 俊英

PAIN RESEARCH　Vol. 22　No. 2　p. 75-75　2007/07

[Repair strategies for the injured central nervous system].

Toshihide Yamashita, Katsuhiko Hata, Atsushi Yamaguchi, Takekazu Kubo

No shinkei geka. Neurological surgery　Vol. 35　No. 7　p. 733-9　2007/07　Research paper (scientific journal)

BMP inhibition enhances axonal regeneration and functional recovery after spinal cord injury

松浦 威一郎, 羽田 克彦, 遠藤 光晴, 村井 尚之, 佐伯 直勝, 山下 俊英

日本神経外傷学会プログラム・抄録集　Vol. 30回　p. 102-102　2007/03

Neogenin and repulsive guidance molecule signaling in the central nervous system

Toshihide Yamashita, Bernhard K. Mueller, Katsuhiko Hata

CURRENT OPINION IN NEUROBIOLOGY　Vol. 17　No. 1　p. 29-34　2007/02　Research paper (scientific journal)

[Regeneration and plasticity of the injured central nervous system].

Toshihide Yamashita, Katsuhiko Hata, Atsushi Yamaguchi, Takekazu Kubo

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 52　No. 1　p. 11-7　2007/01　Research paper (scientific journal)

Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration

Takekazu Kubo, Katsuhiko Hata, Atsushi Yamaguchi, Toshihide Yamashita

CURRENT PHARMACEUTICAL DESIGN　Vol. 13　No. 24　p. 2493-2499　2007

ミエリン由来因子による軸索再生阻害機構

三村 文昭, 藤谷 昌司, 山下 俊英

千葉医学雑誌　Vol. 82　No. 6　p. 326-326　2006/12

Signaling mechanisms of axon growth inhibition

K. Hata, T. Kubo, A. Yamaguchi, T. Yamashita

DRUG NEWS & PERSPECTIVES　Vol. 19　No. 9　p. 541-547　2006/11　Research paper (scientific journal)

Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury

Akiyuki Hiraga, Satoshi Kuwabara, Hideo Doya, Kazuaki Kanai, Masashi Fujitani, Junko Taniguchi, Kimihito Arai, Masahiro Mori, Takamichi Hattori, Toshihide Yamashita

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM　Vol. 11　No. 3　p. 217-224　2006/09　Research paper (scientific journal)

The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system

Bernhard K. Mueller, Toshihide Yamashita, Gregor Schaffar, Reinhold Mueller

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES　Vol. 361　No. 1473　p. 1513-1529　2006/09

Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats

Yutaka Nishio, Masao Koda, Keiko Kitajo, Minoru Seto, Katsuhiko Hata, Junko Taniguchi, Hideshige Moriya, Masashi Fujitani, Takekazu Kubo, Toshihide Yamashita

EXPERIMENTAL NEUROLOGY　Vol. 200　No. 2　p. 392-397　2006/08　Research paper (scientific journal)

Role of Clast1 in development of cerebellar granule cells

Yukiteru Maeda, Lisa Fujimura, Jiyang O-Wang, Masahiko Hatano, Akemi Sakamoto, Masafumi Arima, Masaaki Ebara, Hidetoshi Ino, Toshihide Yamashita, Hiromitsu Saisho, Takeshi Tokuhisa

BRAIN RESEARCH　Vol. 1104　p. 18-26　2006/08　Research paper (scientific journal)

Induction of repulsive guidance molecule in neurons following sciatic nerve injury

Hideo Doya, Toshinori Ito, Katsuhiko Hata, Masashi Fujitani, Seiji Ohtori, Tomoko Saito-Watanabe, Hideshige Moriya, Kazuhisa Takahashi, Takekazu Kubo, Toshihide Yamashita

JOURNAL OF CHEMICAL NEUROANATOMY　Vol. 32　No. 1　p. 74-77　2006/08　Research paper (scientific journal)

[Therapeutic strategy to promote regeneration of the injured central nervous system].

Toshihide Yamashita, Katsuhiko Hata, Atsushi Yamaguchi, Takekazu Kubo

Nihon rinsho. Japanese journal of clinical medicine　Vol. 64　No. 8　p. 1553-60　2006/08　Research paper (scientific journal)

Myelin-associated glycoprotein inhibits microtubule assembly by a rho-kinase-dependent mechanism

F Mimura, S Yamagishi, N Arimura, M Fujitani, T Kubo, K Kaibuchi, T Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 23　p. 15970-15979　2006/06　Research paper (scientific journal)

Progressive hearing loss in mice carrying a mutation in the p75 gene

Takashi Sato, Katsumi Doi, Manabu Taniguchi, Toshihide Yamashita, Takeshi Kubo, Masaya Tohyama

BRAIN RESEARCH　Vol. 1091　p. 224-234　2006/05　Research paper (scientific journal)

RGMa inhibition promotes axonal growth and recovery after spinal cord injury

K Hata, M Fujitani, Y Yasuda, H Doya, T Saito, S Yamagishi, BK Mueller, T Yamashita

JOURNAL OF CELL BIOLOGY　Vol. 173　No. 1　p. 47-58　2006/04　Research paper (scientific journal)

Adenoviral gene transfer in the peripheral nervous system

TS Watanabe, S Ohtori, M Koda, Y Aoki, H Doya, H Shirasawa, M Yamazaki, H Moriya, K Takahashi, T Yamashita

JOURNAL OF ORTHOPAEDIC SCIENCE　Vol. 11　No. 1　p. 64-69　2006/01　Research paper (scientific journal)

【神経保護・再生医療研究の最前線】神経再生 軸索伸展阻害因子と中枢神経再生 Rhoの活性を制御する受容体

山下 俊英, 藤谷 昌司

医学のあゆみ　Vol. 215　No. 10　p. 851-854　2005/12

中枢神経再生阻害の分子機構 軸索再生の可能性

山下 俊英, 藤谷 昌司, 羽田 克彦, 三村 文昭

生化学　Vol. 77　No. 12　p. 1475-1480　2005/12

MAGはRho kinase依存性に微小管を脱重合する

三村 文昭, 藤谷 昌司, 山下 俊英

千葉医学雑誌　Vol. 81　No. 6　p. 344-344　2005/12

Molecular mechanism that inhibits axon regeneration

T Yamashita, M Fujitani, K Hata, F Mimura

SEIKAGAKU　Vol. 77　No. 12　p. 1475-1480　2005/12

中枢神経系の再生とRho/Rho-kinaseの役割

山下 俊英, 藤谷 昌司, 羽田 克彦, 三村 文昭

脳卒中の外科　Vol. 33　No. 6　p. 395-397　2005/11

Multiple signals regulate axon regeneration through the Nogo receptor complex

T Yamashita, M Fujitani, S Yamagishi, K Hata, F Mimura

MOLECULAR NEUROBIOLOGY　Vol. 32　No. 2　p. 105-111　2005/10　Research paper (scientific journal)

Extracellular signal-regulated kinase mitogen-activated protein kinase activation in the dorsal root ganglion (DRG) and spinal cord after DRG injury in rats

H Doya, S Ohtori, K Takahashi, Y Aoki, H Ino, Y Takahashi, H Moriya, T Yamashita

SPINE　Vol. 30　No. 20　p. 2252-2256　2005/10　Research paper (scientific journal)

c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity

H Doya, S Ohtori, M Fujitani, T Saito, K Hata, H Ino, K Takahashi, H Moriya, T Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 335　No. 1　p. 132-138　2005/09　Research paper (scientific journal)

Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75(NTR) to lipid rafts and signal transduction

M Fujitani, H Kawai, RL Proia, A Kashiwagi, H Yasuda, T Yamashita

JOURNAL OF NEUROCHEMISTRY　Vol. 94　No. 1　p. 15-21　2005/07　Research paper (scientific journal)

脳・脊髄はなぜ再生しないのか?

山下 俊英, 藤谷 昌司, 羽田 克彦

千葉医学雑誌　Vol. 81　No. 3　p. 117-118　2005/06

中枢神経の軸索再生のメカニズム

山下 俊英, 藤谷 昌司, 羽田 克彦, 山岸 覚

蛋白質・核酸・酵素　Vol. 50　No. 5　p. 403-409　2005/05

Wallerian degeneration involves Rho/Rho-kinase signaling

S Yamagishi, M Fujitani, K Hata, K Kitajo, F Mimura, H Abe, T Yamashita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 21　p. 20384-20388　2005/05　Research paper (scientific journal)

[Inhibition of axon regeneration by myelin inhibitors].

Toshihide Yamashita, Masashi Fujitani, Katsuhiko Hata, Satoru Yamagishi

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 50　No. 5　p. 403-9　2005/05　Research paper (scientific journal)

Diverse functions of the p75 neurotrophin receptor

Toshihide Yamashita, Masashi Fujitani, Katsuhiko Hata, Fumiaki Mimura, Satoru Yamagishi

Anatomical Science International　Vol. 80　No. 1　p. 37-41　2005/03　Research paper (scientific journal)

Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts

M Fujitani, A Honda, K Hata, S Yamagishi, M Tohyama, T Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 327　No. 1　p. 150-154　2005/02　Research paper (scientific journal)

Rho/Rho-kinase as potential therapeutic targets for CNS injury.

Yamashita, T, Fujitani, M, Hata, K, Mimura, F, Taniguchi, J

Gene Therapy and Molecular Biology　Vol. 9　p. 265-268　2005

中枢神経再生阻害因子のシグナル伝達機構

藤谷 昌司, 山下 俊英, 川合 寛道, 遠山 昌彌, 安田 斎

臨床神経学　Vol. 44　No. 12　p. 1039-1039　2004/12

P311 accelerates nerve regeneration of the axotomized facial nerve

M Fujitani, S Yamagishi, YH Che, K Hata, T Kubo, H Ino, M Tohyama, T Yamashita

JOURNAL OF NEUROCHEMISTRY　Vol. 91　No. 3　p. 737-744　2004/11　Research paper (scientific journal)

Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein

T Mizuno, T Yamashita, M Tohyama

JOURNAL OF NEUROCHEMISTRY　Vol. 91　No. 2　p. 395-403　2004/10　Research paper (scientific journal)

【解明が進む神経軸索伸長の基本メカニズム 神経の再生医療を目指して】ミエリン由来因子による軸索再生阻害機構

山下 俊英, 藤谷 昌司, 羽田 克彦

細胞工学　Vol. 23　No. 9　p. 1052-1054　2004/08

ミエリン由来軸索伸展阻害因子のlipid raftを介するシグナル伝達機構(Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75 NTR to lipid rafts and signal transduction)

藤谷 昌司, 川合 寛道, 山下 俊英

神経化学　Vol. 43　No. 2-3　p. 427-427　2004/08

EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway

M Aoki, T Yamashita, M Tohyama

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 31　p. 32643-32650　2004/07　Research paper (scientific journal)

Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of G(i)/G

Y Hasegawa, M Fujitani, K Hata, M Tohyama, S Yamagishi, T Yamashita

JOURNAL OF NEUROSCIENCE　Vol. 24　No. 30　p. 6826-6832　2004/07　Research paper (scientific journal)

Cytoplasmic p21Cip1/WAF1 enhances axonal regeneration and functional recovery after spinal cord injury in rats

Tanaka H, Yamashita T, Yachi K, Fujiwara T, Yoshikawa H, Tohayama M

Neuroscience　Vol. 127　No. 1　p. 155-164　2004/06

中枢神経回路はなぜ再生しないのか

山下 俊英, 山岸 覚, 羽田 克彦, 藤谷 昌司

千葉医学雑誌　Vol. 80　No. 2　p. 47-51　2004/04

Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nerve transection

T Madura, T Yamashita, T Kubo, L Tsuji, K Hosokawa, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 123　No. 1-2　p. 76-80　2004/04　Research paper (scientific journal)

Activation of Rho in the injured axons following spinal cord injury

T Madura, T Yamashita, T Kubo, M Fujitani, K Hosokawa, M Tohyama

EMBO REPORTS　Vol. 5　No. 4　p. 412-417　2004/04　Research paper (scientific journal)

FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth

L Tsuji, T Yamashita, T Kubo, T Madura, H Tanaka, K Hosokawa, M Tohyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 313　No. 4　p. 1086-1091　2004/01　Research paper (scientific journal)

p75 neurotrophin receptor signaling in the nervous system

Yuiko Hasegawa, Satoru Yamagishi, Masashi Fujitani, Toshihide Yamashita

Biotechnology Annual Review　Vol. 10　p. 123-149　2004

Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain

A Kawakita, T Yamashita, M Taniguchi, Y Koyama, T Kubo, L Tsuji, M Tohyama

DEVELOPMENTAL BRAIN RESEARCH　Vol. 144　No. 2　p. 181-189　2003/09　Research paper (scientific journal)

Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain

T Madura, T Yamashita, T Kubo, M Taniguchi, A Kawakita, K Hosokawa, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 114　No. 2　p. 163-167　2003/06　Research paper (scientific journal)

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

T Yamashita, M Tohyama

NATURE NEUROSCIENCE　Vol. 6　No. 5　p. 461-467　2003/05　Research paper (scientific journal)

PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts

H Higuchi, T Yamashita, H Yoshikawa, M Tohyama

EMBO JOURNAL　Vol. 22　No. 8　p. 1790-1800　2003/04　Research paper (scientific journal)

Functional inhibition of the p75 receptor using a small interfering RNA

H Higuchi, T Yamashita, H Yoshikawa, M Tohyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 301　No. 3　p. 804-809　2003/02　Research paper (scientific journal)

The p75 receptor is required for BDNF-induced differentiation of neural precursor cells

S Hosomi, T Yamashita, M Aoki, M Tohyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 301　No. 4　p. 1011-1015　2003/02　Research paper (scientific journal)

Induction of mRNAs and proteins for Na/K ATPase alpha l and beta 1 subunits following hypoxia/reoxygenation in astrocytes

K Kasai, T Yamashita, A Yamaguchi, K Yoshiya, A Kawakita, H Tanaka, H Sugimoto, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 110　No. 1　p. 38-44　2003/01　Research paper (scientific journal)

A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling

T Kubo, T Yamashita, A Yamaguchi, H Sumimoto, K Hosokawa, M Tohyama

JOURNAL OF NEUROSCIENCE　Vol. 22　No. 19　p. 8504-8513　2002/10　Research paper (scientific journal)

Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays

T Kubo, T Yamashita, A Yamaguchi, K Hosokawa, M Tohyama

JOURNAL OF NEUROCHEMISTRY　Vol. 82　No. 5　p. 1129-1136　2002/09　Research paper (scientific journal)

Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity

H Tanaka, T Yamashita, M Asada, S Mizutani, H Yoshikawa, M Tohyama

JOURNAL OF CELL BIOLOGY　Vol. 158　No. 2　p. 321-329　2002/07　Research paper (scientific journal)

Identification and characterization of a novel mitochondrial tricarboxylate carrier

S Miyake, T Yamashita, M Taniguchi, M Tamatani, K Sato, M Tohyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 295　No. 2　p. 463-468　2002/07　Research paper (scientific journal)

Changes in mRNA for VAMPs following facial nerve transection

YH Che, T Yamashita, M Tohyama

JOURNAL OF CHEMICAL NEUROANATOMY　Vol. 24　No. 2　p. 147-152　2002/07　Research paper (scientific journal)

Changes in mRNA for choline transporter-like protein following facial nerve transection

YH Che, T Yamashita, H Higuchi, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 101　No. 1-2　p. 122-125　2002/05　Research paper (scientific journal)

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho

T Yamashita, H Higuchi, M Tohyama

JOURNAL OF CELL BIOLOGY　Vol. 157　No. 4　p. 565-570　2002/05　Research paper (scientific journal)

Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain

S Miyake, T Yamashita, M Taniguchi, M Tamatani, K Sato, Y Kawai, E Senba, N Mitsuda, O Hori, A Yamaguchi, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 100　No. 1-2　p. 67-73　2002/04　Research paper (scientific journal)

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism

H Neumann, RD Schweigreiter, T Yamashita, K Rosenkranz, H Wekerle, YA Barde

JOURNAL OF NEUROSCIENCE　Vol. 22　No. 3　p. 854-862　2002/02　Research paper (scientific journal)

Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia

A Yamaguchi, M Taniguchi, O Hori, S Ogawa, N Tojo, N Matsuoka, S Miyake, K Kasai, H Sugimoto, M Tamatani, T Yamashita, M Tohyama

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 1　p. 623-629　2002/01　Research paper (scientific journal)

Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus

T Yamashita, Liu, X, T Onaka, K Honda, T Saito, K Yagi

NEUROREPORT　Vol. 12　No. 16　p. 3509-3511　2001/11　Research paper (scientific journal)

Medullary A1 noradrenergic neurones may mediate oxytocin release after noxious stimuli

T Onaka, T Yamashita, Liu, X, K Honda, T Saito, K Yagi

NEUROREPORT　Vol. 12　No. 11　p. 2499-2502　2001/08　Research paper (scientific journal)

The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats

K Tanabe, T Tachibana, T Yamashita, YH Che, Y Yoneda, T Ochi, M Tohyama, H Yoshikawa, H Kiyama

JOURNAL OF NEUROSCIENCE　Vol. 20　No. 11　p. 4138-4144　2000/06　Research paper (scientific journal)

Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat.

Taniguchi M, Yamashita T, Kumura E, Tamatani M, Kobayashi A, Yokawa T, Maruno M, Kato A, Ohnishi T, Kohmura E, Tohyama M, Yoshimine T

Brain Res. Mol Brain Res　Vol. 78　No. 1-2　p. 131-137　2000/05　Research paper (scientific journal)

Changes in mRNA of protein inhibitor of neuronal nitric oxide synthase following facial nerve transection

YH Che, M Tamatani, T Yamashita, F Gomi, S Ogawa, M Tohyama

JOURNAL OF CHEMICAL NEUROANATOMY　Vol. 17　No. 4　p. 199-206　2000/01　Research paper (scientific journal)

Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth

T Yamashita, KL Tucker, YA Barde

NEURON　Vol. 24　No. 3　p. 585-593　1999/11　Research paper (scientific journal)

Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice.

Miyawaki, K, Yamada, Y, Yano, H, Niwa, H, Ban, N, Ihara, Y, Kubota, A, Fujimoto, S, Kajikawa, M, Kuroe, A, Tsuda, K, Hashimoto, H, Yamashita, T, Jomori, T, Tashiro, F, Miyazaki, J, Seino, Y

Proc. Natl. Acad. Sci. USA.　Vol. 96　p. 14843-14847　1999/11　Research paper (scientific journal)

Neuroprotective role of Na+/myo-inositol cotransporter against veratridine cytotoxicity

T Yamashita, A Yamauchi, A Miyai, M Taniguchi, T Yoshimine, M Tohyama

JOURNAL OF NEUROCHEMISTRY　Vol. 72　No. 5　p. 1864-1870　1999/05　Research paper (scientific journal)

Differential regulation of adenine nucleotide translocators by hypertonicity in the brain

T Yamashita, A Yamauchi, A Miyai, M Taniguchi, T Yoshimine, M Tohyama

JOURNAL OF NEUROCHEMISTRY　Vol. 72　No. 3　p. 1259-1265　1999/03　Research paper (scientific journal)

Cloning of a bovine orphan transporter and its short splicing variant

Kazuko Sakata, Shoichi Shimada, Toshihide Yamashita, Kiyoshi Inoue, Masaya Tohyama

FEBS Letters　Vol. 443　No. 3　p. 267-270　1999/01/29　Research paper (scientific journal)

Regulation of Na+/myo-inositol cotransporter gene expression in hyperglycemic rat hippocampus

T Yamashita, M Tamatani, M Taniguchi, T Takagi, T Yoshimine, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 57　No. 1　p. 167-172　1998/06　Research paper (scientific journal)

Changes in brain organic osmolytes in experimental cerebral ischemia.

M Nonaka, T Yoshimine, E Kohmura, A Wakayama, T Yamashita, T Hayakawa

Journal of the neurological sciences　Vol. 157　No. 1　p. 25-30　1998/04/15　Research paper (scientific journal)

Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure

M Nonaka, E Kohmura, T Yamashita, S Shimada, K Tanaka, T Yoshimine, M Tohyama, T Hayakawa

MOLECULAR BRAIN RESEARCH　Vol. 55　No. 1　p. 54-60　1998/03　Research paper (scientific journal)

Developmental regulation of Na+/myo-inositol cotransporter gene expression

Wei Guo, Shoichi Shimada, Hitoshi Tajiri, Atsushi Yamauchi, Toshihide Yamashita, Shintaro Okada, Masaya Tohyama

Molecular Brain Research　Vol. 51　No. 1-2　p. 91-96　1997/11　Research paper (scientific journal)

Expression of growth inhibitory factor mRNA after focal ischemia in rat brain.

T Yuguchi, E Kohmura, T Sakaki, M Nonaka, K Yamada, T Yamashita, T Kishiguchi, T Sakaguchi, T Hayakawa

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　Vol. 17　No. 7　p. 745-52　1997/07　Research paper (scientific journal)

Cloning and functional expression of a brain peptide/histidine transporter

T Yamashita, S Shimada, W Guo, K Sato, E Kohmura, T Hayakawa, T Takagi, M Tohyama

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 15　p. 10205-10211　1997/04　Research paper (scientific journal)

Altered expression of Growth Inhibitory Factor (GIF / MT-III) mRNA in the rat facial nucleus after facial nerve injury is closely related with facial function.

E Kohmura, T Yuguchi, T Sakaki, T Yamashita, M Nonaka, T Hayakawa

Restorative neurology and neuroscience　Vol. 11　No. 3　p. 169-75　1997/01/01　Research paper (scientific journal)

Expression of tPA mRNA in the facial nucleus following facial nerve transection in the rat

T Yuguchi, E Kohmura, K Yamada, H Otsuki, T Sakaki, T Yamashita, M Nonaka, T Sakaguchi, A Wanaka, T Hayakawa

NEUROREPORT　Vol. 8　No. 2　p. 419-422　1997/01　Research paper (scientific journal)

Induction of Na+/myo-inositol co-transporter mRNA after rat cryogenic injury

Toshihide Yamashita, Shoichi Shimada, Atsushi Yamauchi, Wei Guo, Eiji Kohmura, Toru Hayakawa, Masaya Tohyama

Molecular Brain Research　Vol. 46　No. 1-2　p. 236-242　1997　Research paper (scientific journal)

Coordinate expression of a-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells.

Kashiwada K, Nishida W, Hayashi K, Ozawa K, Yamanaka Y, Saga H, Yamashita T, Tohyama M, Shimada S, Sato K, Sobue K

J Biol Chem　Vol. 272　p. 15396-15404　1997

Changes in glutamate/aspartate transporter (GLAST/GluT-1) mRNA expression following facial nerve transection

T Yamashita, E Kohmura, T Yuguchi, S Shimada, K Tanaka, T Hayakawa, M Tohyama

MOLECULAR BRAIN RESEARCH　Vol. 38　No. 2　p. 294-299　1996/06　Research paper (scientific journal)

Induction of Na+/myo-inositol cotransporter mRNA after focal cerebral ischemia: Evidence for extensive osmotic stress in remote areas

Toshihide Yamashita, Eiji Kohmura, Atsushi Yamauchi, Shoichi Shimada, Takamichi Yuguchi, Takayuki Sakaki, Akiko Miyai, Masaya Tohyama, Toru Hayakawa

Journal of Cerebral Blood Flow and Metabolism　Vol. 16　No. 6　p. 1203-1210　1996　Research paper (scientific journal)

Changes in growth inhibitory factor mRNA expression compared with those in c-jun mRNA expression following facial nerve transection.

Yuguchi T, Kohmura E, Yamada K, Sakaki T, Yamashita T, Otsuki H, Wanaka A, Tohyama M, Tsuji S, Hayakawa T

Brain research. Molecular brain research　Vol. 28　No. 2　p. 181-185　1995/02

シンポジウム1:脳虚血をめぐる病態・研究の進歩

早川 徹, 福内 靖男, 松本 昌泰, 片山 泰朗, 神谷 達司, 赫 彰郎, 山田 和雄, 真砂 敦夫, 金井 秀樹, 神谷 健, 榊 孝之, 湯口 貴導, 山下 俊英, 大槻 秀夫, 甲村 英二, 早川 徹, 阿部 康二, 松居 徹, 田中 耕太郎

脳卒中　Vol. 17　No. 6　p. 501-540　1995

Messenger RNA and protein expression of basic fibroblast growth factor receptor after cortical ablation.

Yuguchi T, Kohmura E, Yamada K, Wanaka A, Otsuki H, Sakaguchi T, Yamashita T, Tohyama M, Hayakawa T

Brain research. Molecular brain research　Vol. 25　No. 1-2　p. 50-56　1994/08

Ontogeny of calcitonin gene-related peptide in the organ of Cortl of the rat

Y. Tohyama, H. Kiyama, M. Kitajiri, T. Yamashita, T. Kumazawa, M. Tohyama

Developmental Brain Research　Vol. 45　No. 2　p. 309-312　1989/02/01　Research paper (scientific journal)

EFFECTIVE MAGNETIC-FLUX OF NBN NANOBRIDGES IN A DC-SQUID

T YAMASHITA, K HOSOKAWA

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　Vol. 26　No. 3　p. 391-395　1987/03　Research paper (scientific journal)