Higd1a improves respiratory function in the models of mitochondrial disorder.

Takemasa Nagao, Yasunori Shintani, Takaharu Hayashi, Hidetaka Kioka, Hisakazu Kato, Yuya Nishida, Satoru Yamazaki, Osamu Tsukamoto, Shohei Yashirogi, Issei Yazawa, Yoshihiro Asano, Kyoko Shinzawa-Itoh, Hiromi Imamura, Takeo Suzuki, Tsutomu Suzuki, Yu-Ichi Goto, Seiji Takashima

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 34　No. 1　p. 1859-1871　2020/01

A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.

Kenta Kamikubo, Hisakazu Kato, Hidetaka Kioka, Satoru Yamazaki, Osamu Tsukamoto, Yuya Nishida, Yoshihiro Asano, Hiromi Imamura, Hiroyuki Kawahara, Yasunori Shintani, Seiji Takashima

The Journal of biological chemistry　Vol. 294　No. 40　p. 14562-14573　2019/10/04　Research paper (scientific journal)

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation

Noriaki Yamada, Yoshihiro Asano, Masashi Fujita, Satoru Yamazaki, Atsushi Inanobe, Norio Matsuura, Hatasu Kobayashi, Seiko Ohno, Yusuke Ebana, Osamu Tsukamoto, Saki Ishino, Ayako Takuwa, Hidetaka Kioka, Toru Yamashita, Norio Hashimoto, Dimitar P. Zankov, Akio Shimizu, Masanori Asakura, Hiroshi Asanuma, Hisakazu Kato, Yuya Nishida, Yohei Miyashita, Haruki Shinomiya, Nobu Naiki, Kenshi Hayashi, Takeru Makiyama, Hisakazu Ogita, Katsuyuki Miura, Hirotsugu Ueshima, Issei Komuro, Masakazu Yamagishi, Minoru Horie, Koichi Kawakami, Tetsushi Furukawa, Akio Koizumi, Yoshihisa Kurachi, Yasushi Sakata, Tetsuo Minamino, Masafumi Kitakaze, Seiji Takashima

Circulation　Vol. 139　No. 18　p. 2157-2169　2019/04　Research paper (scientific journal)

Higd1a is a positive regulator of cytochrome c oxidase

Takaharu Hayashi, Yoshihiro Asano, Yasunori Shintani, Hiroshi Aoyama, Hidetaka Kioka, Osamu Tsukamoto, Masahide Hikita, Kyoko Shinzawa-Itoh, Kazuaki Takafuji, Shuichiro Higo, Hisakazu Kato, Satoru Yamazaki, Ken Matsuoka, Atsushi Nakano, Hiroshi Asanuma, Masanori Asakura, Tetsuo Minamino, Yu-ichi Goto, Takashi Ogura, Masafumi Kitakaze, Issei Komuro, Yasushi Sakata, Tomitake Tsukihara, Shinya Yoshikawa, Seiji Takashima

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 112　No. 5　p. 1553-1558　2015/02　Research paper (scientific journal)

Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5

Yi Yan, Osamu Tsukamoto, Atsushi Nakano, Hisakazu Kato, Hidetaka Kioka, Noriaki Ito, Shuichiro Higo, Satoru Yamazaki, Yasunori Shintani, Ken Matsuoka, Yulin Liao, Hiroshi Asanuma, Masanori Asakura, Kazuaki Takafuji, Tetsuo Minamino, Yoshihiro Asano, Masafumi Kitakaze, Seiji Takashima

NATURE COMMUNICATIONS　Vol. 6　2015/01　Research paper (scientific journal)

Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation

Hidetaka Kioka, Hisakazu Kato, Makoto Fujikawa, Osamu Tsukamoto, Toshiharu Suzuki, Hiromi Imamura, Atsushi Nakano, Shuichiro Higo, Satoru Yamazaki, Takashi Matsuzaki, Kazuaki Takafuji, Hiroshi Asanuma, Masanori Asakura, Tetsuo Minamino, Yasunori Shintani, Masasuke Yoshida, Hiroyuki Noji, Masafumi Kitakaze, Issei Komuro, Yoshihiro Asano, Seiji Takashima

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 1　p. 273-278　2014/01　Research paper (scientific journal)

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

Atsushi Nakano, Hisakazu Kato, Takashi Watanabe, Kyung-Duk Min, Satoru Yamazaki, Yoshihiro Asano, Osamu Seguchi, Shuichiro Higo, Yasunori Shintani, Hiroshi Asanuma, Masanori Asakura, Tetsuo Minamino, Kozo Kaibuchi, Naoki Mochizuki, Masafumi Kitakaze, Seiji Takashima

NATURE CELL BIOLOGY　Vol. 12　No. 6　p. 583-U139　2010/06　Research paper (scientific journal)

A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart

Osamu Seguchi, Seiji Takashima, Satoru Yamazaki, Masanori Asakura, Yoshihiro Asano, Yasunori Shintani, Masakatsu Wakeno, Tetsuo Minamino, Hiroya Kondo, Hidehiko Furukawa, Kenji Nakamaru, Asuka Naito, Tomoko Takahashi, Toshiaki Ohtsuka, Koichi Kawakami, Tadashi Isomura, Soichiro Kitamura, Hitonobu Tomoike, Naoki Mochizuki, Masafumi Kitakaze

JOURNAL OF CLINICAL INVESTIGATION　Vol. 117　No. 10　p. 2812-2824　2007/10　Research paper (scientific journal)

Lamr1 functional retroposon causes right ventricular dysplasia in mice

Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, H Asanuma, S Sanada, J Kim, A Ogai, T Fukushima, Y Oikawa, Y Okazaki, Y Kaneda, M Sato, J Miyazaki, S Kitamura, H Tomoike, M Kitakaze, M Hori

NATURE GENETICS　Vol. 36　No. 2　p. 123-130　2004/02　Research paper (scientific journal)

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

S Soker, S Takashima, HQ Miao, G Neufeld, M Klagsbrun

CELL　Vol. 92　No. 6　p. 735-745　1998/03　Research paper (scientific journal)

LSMEM2, Localized at the Neuromuscular Junction, Modulates Mitochondrial Integration in Skeletal Muscles.

Eman Elrefaei, Satoru Yamazaki, Issei Yazawa, Yusuke Takahashi, Naoki Ito, Nozomi Hayashiji, Yuya Nishida, Ichizo Nishino, Seiji Takashima, Yasunori Shintani

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 39　No. 12　2025/06/30　Research paper (scientific journal)

Pocking the Ear for HFpEF?

Yochai Birnbaum, Seiji Takashima

Cardiovascular drugs and therapy　2025/04/30

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by spatial and single-cell transcriptomics.

Tasneem Qaqorh, Yusuke Takahashi, Kohei Sameshima, Kentaro Otani, Issei Yazawa, Yuya Nishida, Kohei Tonai, Yoshitaka Fujihara, Mizuki Honda, Shinya Oki, Yasuyuki Ohkawa, David R Thorburn, Ann E Frazier, Atsuhito Takeda, Yoshihiko Ikeda, Heima Sakaguchi, Takuya Watanabe, Norihide Fukushima, Yasumasa Tsukamoto, Naomasa Makita, Osamu Yamaguchi, Kei Murayama, Akira Ohtake, Yasushi Okazaki, Takanari Kimura, Hisakazu Kato, Hijiri Inoue, Ken Matsuoka, Seiji Takashima, Yasunori Shintani

Science advances　Vol. 11　No. 14　2025/04/04　Research paper (scientific journal)

Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4–related amyloidosis

Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Hideaki Kawai, Isao Matsui, Tadashi Yamamuro, Ryuya Edahiro, Seiji Takashima, Akira Takasawa, Yukinori Okada, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

JCI Insight　Vol. 10　No. 3　2025/02/10　Research paper (scientific journal)

HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response.

Shunsuke Nishimura, Hidetaka Kioka, Shan Ding, Hideyuki Hakui, Haruki Shinomiya, Kazuya Tanabe, Tatsuro Hitsumoto, Ken Matsuoka, Hisakazu Kato, Osamu Tsukamoto, Yoshihiro Asano, Seiji Takashima, Radoslav I Enchev, Yasushi Sakata

EMBO reports　2025/02/06　Research paper (scientific journal)

Betagenin ameliorates diabetes by inducing insulin secretion and β-cell proliferation.

Tomotaka Yokoo, Kazuhisa Watanabe, Kaoruko Iida, Yutaka Nakachi, Hiroaki Suzuki, Hitoshi Shimano, Seiji Takashima, Yasushi Okazaki, Nobuhiro Yamada, Hideo Toyoshima

The Journal of biological chemistry　Vol. 301　No. 2　p. 108202-108202　2025/02　Research paper (scientific journal)

Enhanced fatty acid oxidation by selective activation of PPARα alleviates autoimmunity through metabolic transformation in T-cells.

Satoshi Masuyama, Masayuki Mizui, Masashi Morita, Takatomo Shigeki, Hisakazu Kato, Takeshi Yamamoto, Yusuke Sakaguchi, Kazunori Inoue, Tomoko Namba-Hamano, Isao Matsui, Tatsusada Okuno, Ryohei Yamamoto, Seiji Takashima, Yoshitaka Isaka

Clinical immunology (Orlando, Fla.)　Vol. 268　p. 110357-110357　2024/11　Research paper (scientific journal)

Metabolic syndrome is linked to most cancers incidence.

Naoki Kimoto, Yohei Miyashita, Yutaka Yata, Takeshi Aketa, Masami Yabumoto, Yasushi Sakata, Takashi Washio, Seiji Takashima, Masafumi Kitakaze

Heart and vessels　2024/10/09　Research paper (scientific journal)

Endogenous activation of peroxisome proliferator-activated receptor alpha in proximal tubule cells in counteracting phosphate toxicity.

Yusuke Katsuma, Isao Matsui, Ayumi Matsumoto, Hiroki Okushima, Atsuhiro Imai, Yusuke Sakaguchi, Takeshi Yamamoto, Masayuki Mizui, Shohei Uchinomiya, Hisakazu Kato, Akio Ojida, Seiji Takashima, Kazunori Inoue, Yoshitaka Isaka

American journal of physiology. Renal physiology　2024/06/13　Research paper (scientific journal)

BRAF V600E-induced distinct DNA damage response defines the therapeutic potential of p53 activation for TP53 wild-type colorectal cancer.

Shinji Tokuyama, Hisakazu Kato, Hidekazu Takahashi, Kyoko Ueda, Asami Arita, Ryuta Ueda, Hiroto Seto, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Ken Matsuoka, Osamu Tsukamoto, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi, Seiji Takashima

Carcinogenesis　2024/06/13　Research paper (scientific journal)

MondoA and AKI and AKI-to-CKD Transition.

Shihomi Maeda, Shinsuke Sakai, Yoshitsugu Takabatake, Takeshi Yamamoto, Satoshi Minami, Jun Nakamura, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Sho Matsui, Atsuhiro Imai, Ryuya Edahiro, Hitomi Yamamoto-Imoto, Isao Matsui, Seiji Takashima, Ryoichi Imamura, Norio Nonomura, Motoko Yanagita, Yukinori Okada, Andrea Ballabio, Shuhei Nakamura, Tamotsu Yoshimori, Yoshitaka Isaka

Journal of the American Society of Nephrology : JASN　2024/05/31　Research paper (scientific journal)

Relative B-Type Natriuretic Peptide Deficiency May Exist in Diastolic Dysfunction in Subclinical Population

Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze

Circulation Reports　Vol. 6　No. 5　p. 151-160　2024/05/10　Research paper (scientific journal)

Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals

Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze

JACC: Asia　2024/01　Research paper (scientific journal)

Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin".

Osamu Tsukamoto, Seiji Takashima

Circulation　Vol. 148　No. 25　p. 2074-2075　2023/12/19

心不全病態特異的エンハンサークラスターによるNa利尿ペプチド遺伝子の転写制御機構

井上 聖, 松岡 研, ゾ・ヘジン, 塚本 蔵, 高島 成二

日本生化学会大会プログラム・講演要旨集　Vol. 96回　p. [2P-409]　2023/10

Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload

Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Issei Komuro, Akira Kikuchi, Ichiro Shiojima

iScience　p. 107146-107146　2023/06　Research paper (scientific journal)

CR9はナトリウム利尿ペプチド遺伝子のエンハンサーとして発現を調節する(CR9 regulates transcription expression as an enhancer of the atrial and brain natriuretic peptide gene in cardiomyocytes)

Jo Hyejin, Matsuoka Ken, Inoue Hijiri, Tsukamoto Osamu, Takashima Seiji

The Journal of Physiological Sciences　Vol. 73　No. Suppl.1　p. 224-224　2023/05

Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier

Satoshi Kameda, Shuichiro Higo, Mikio Shiba, Takumi Kondo, Junjun Li, Li Liu, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Yuki Kuramoto, Hideki Yasutake, Jong-Kook Lee, Seiji Takashima, Yoshihiko Ikeda, Shungo Hikoso, Shigeru Miyagawa, Yasushi Sakata

JACC: Basic to Translational Science　2023/02　Research paper (scientific journal)

ナトリウム利尿ペプチド遺伝子を制御する心不全感受性エンハンサークラスターの解明

井上 聖, 松岡 研, ゾ・ヘジン, 塚本 蔵, 高島 成二

日本生化学会大会プログラム・講演要旨集　Vol. 95回　p. 3T14a-01　2022/11

ナトリウム利尿ペプチドの転写を制御するエンハンサー領域と結合する転写因子群の同定

Jo Hyejin, 松岡 研, 井上 聖, 塚本 蔵, 高島 成二

日本生化学会大会プログラム・講演要旨集　Vol. 95回　p. 3T14a-02　2022/11

Multiplexed measurement of cell type-specific calcium kinetics using high-content image analysis combined with targeted gene disruption

Tomoka Tabata, Yuki Masumura, Shuichiro Higo, Suzuka Kunimatsu, Satoshi Kameda, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Seiji Takashima, Mikio Watanabe, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata

Biochemical and Biophysical Research Communications　2022/11　Research paper (scientific journal)

Candidate screening for heart failure with preserved ejection fraction clinic by Fib-4 index from subclinical subjects

Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Tatsuro Hitsumoto, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze

Gastro Hep Advances　2022/09　Research paper (scientific journal)

Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy

Takumi Kondo, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Satoki Nakamura, Maki Takeda, Emiko Ito, Junjun Li, Li Liu, Yuki Kuramoto, Jong-Kook Lee, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Circulation: Genomic and Precision Medicine　2022/07/12　Research paper (scientific journal)

核膜タンパク質の変異による不整脈原性心筋症の新たな分子メカニズム(A Novel Molecular Mechanism of Arrhythmogenic Cardiomyopathy Caused by a Mutation in the Nuclear Envelope Protein)

四宮 春輝, Asano Yoshihiro, Kato Hisakazu, Kuramoto Yuki, Watanabe Nozomi, Tsuruda Toshihiro, Miyashita Yohei, Kioka Hidetaka, Kitakaze Masafumi, Takashima Seiji, Sakata Yasushi

日本循環器学会学術集会抄録集　Vol. 86回　p. U45-4　2022/03

A Novel Molecular Mechanism of Arrhythmogenic Cardiomyopathy Caused by a Mutation in the Nuclear Envelope Protein(和訳中)

四宮 春輝, Asano Yoshihiro, Kato Hisakazu, Kuramoto Yuki, Watanabe Nozomi, Tsuruda Toshihiro, Miyashita Yohei, Kioka Hidetaka, Kitakaze Masafumi, Takashima Seiji, Sakata Yasushi

日本循環器学会学術集会抄録集　Vol. 86回　p. U45-4　2022/03

Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes.

Hiroyuki Inoue, Satoki Nakamura, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Takumi Kondo, Satoshi Kameda, Tomoka Tabata, Shota Okuno, Yoshihiko Ikeda, Junjun Li, Li Liu, Satoru Yamazaki, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Stem cell reports　Vol. 17　No. 2　p. 337-351　2022/02/08　Research paper (scientific journal)

Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model.

Ryohei Oya, Osamu Tsukamoto, Tatsuro Hitsumoto, Naoya Nakahara, Chisato Okamoto, Ken Matsuoka, Hisakazu Kato, Hidenori Inohara, Seiji Takashima

International journal of molecular sciences　Vol. 23　No. 3　2022/02/03　Research paper (scientific journal)

Lower B-type natriuretic peptide levels predict left ventricular concentric remodelling and insulin resistance.

Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Tatsuro Hitsumoto, Ken Matsuoka, Seiji Takashima, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Shin Ito, Masafumi Kitakaze

ESC heart failure　Vol. 9　No. 1　p. 636-647　2022/02　Research paper (scientific journal)

ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis.

Kyung-Duk Min, Masanori Asakura, Manabu Shirai, Satoru Yamazaki, Shin Ito, Hai Ying Fu, Hiroshi Asanuma, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Masafumi Kitakaze

Scientific reports　Vol. 11　No. 1　p. 23056-23056　2021/11/29　Research paper (scientific journal)

Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy.

Haruki Shinomiya, Hisakazu Kato, Yuki Kuramoto, Nozomi Watanabe, Toshihiro Tsuruda, Tadaaki Arimura, Yohei Miyashita, Yoshiki Miyasaka, Tomoji Mashimo, Ayako Takuwa, Daisuke Motooka, Daisuke Okuzaki, Ken Matsuoka, Osamu Tsukamoto, Hideyuki Hakui, Noriaki Yamada, Jong-Kook Lee, Hidetaka Kioka, Masafumi Kitakaze, Seiji Takashima, Yasushi Sakata, Yoshihiro Asano

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 35　No. 11　2021/11　Research paper (scientific journal)

Visualization of Spatial Distribution of Spermatogenesis in Mouse Testes Using Creatine Chemical Exchange Saturation Transfer Imaging.

Yusuke Takahashi, Hidetaka Kioka, Shinichiro Fukuhara, Sohei Kuribayashi, Shigeyoshi Saito, Yoshihiro Asano, Seiji Takashima, Yoshichika Yoshioka, Yasushi Sakata

Journal of magnetic resonance imaging : JMRI　Vol. 54　No. 5　p. 1457-1465　2021/05/30　Research paper (scientific journal)

Phenotypic Recapitulation and Correction of Desmoglein-2-deficient Cardiomyopathy using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

Mikio Shiba, Shuichiro Higo, Takumi Kondo, Junjun Li, Li Liu, Yoshihiko Ikeda, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Satoki Nakamura, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Human Molecular Genetics　2021/05/05　Research paper (scientific journal)

Accurate Estimation of the Duration of Testicular Ischemia Using Creatine Chemical Exchange Saturation Transfer (CrCEST) Imaging.

Yusuke Takahashi, Hidetaka Kioka, Shigeyoshi Saito, Shinichiro Fukuhara, Yoshihiro Asano, Seiji Takashima, Yoshichika Yoshioka, Yasushi Sakata

Journal of magnetic resonance imaging : JMRI　Vol. 53　No. 5　p. 1559-1567　2021/05　Research paper (scientific journal)

Phosphorylation of MYL12 by Myosin Light Chain Kinase Regulates Cellular Shape Changes in Cochlear Hair Cells.

Ryohei Oya, Osamu Tsukamoto, Takashi Sato, Hisakazu Kato, Ken Matsuoka, Kazuo Oshima, Takefumi Kamakura, Yumi Ohta, Takao Imai, Seiji Takashima, Hidenori Inohara

Journal of the Association for Research in Otolaryngology : JARO　Vol. 22　No. 4　p. 425-441　2021/04/20　Research paper (scientific journal)

BAG Cochaperone 5の欠失は若年性拡張型心筋症の原因となる(Loss of BAG Cochaperone 5 Causes Juvenile-onset Dilated Cardiomyopathy)

Hakui Hideyuki, Asano Yoshihiro, Kioka Hidetaka, Miyashita Yohei, Kuramoto Yuki, Takahashi Yusuke, Yamamoto Hironori, Nishimura Shunsuke, Ohtani Tomohito, Sawa Yoshiki, Takashima Seiji, Sakata Yasushi

日本循環器学会学術集会抄録集　Vol. 85回　p. YIA-4　2021/03

Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes.

Yasuaki Kohama, Shuichiro Higo, Yuki Masumura, Mikio Shiba, Takumi Kondo, Takamaru Ishizu, Tomoaki Higo, Satoki Nakamura, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Scientific reports　Vol. 10　No. 1　p. 15348-15348　2020/09/18　Research paper (scientific journal)

心臓および病態特異的エンハンサーCR9は力学的負荷で活性化されBNP発現を増加する

坪田 朋也, 松岡 研, 塚本 蔵, 高島 成二

日本生化学会大会プログラム・講演要旨集　Vol. 93回　p. [1Z07-460)]　2020/09

Tmem43 S358L変異による不整脈源性心筋症の病態および分子メカニズムの解明(Elucidation of The Pathological and Molecular Mechanism Underlying Arrhythmogenic Cardiomyopathy Caused by Tmem43 S358L Mutation)

Shinomiya Haruki, Asano Yoshihiro, Kato Hisakazu, Kuramoto Yuki, Watanabe Nozomi, Tsuruda Toshihiro, Miyashita Yohei, Kioka Hidetaka, Takashima Seiji, Sakata Yasushi

日本循環器学会学術集会抄録集　Vol. 84回　p. YIA審査講演会(Basic Research)-1　2020/07

徐脈性不整脈の薬理学的標的としての機能獲得型変異体IKAChチャネル(Gain-of-function Mutant IKACh Channels as a Pharmacological Target for Bradyarrhythmia)

山田 憲明, 朝野 仁裕, 稲野辺 厚, 石綿 紀久, 倉智 嘉久, 北風 政史, 坂田 泰史, 高島 成二

日本循環器学会学術集会抄録集　Vol. 84回　p. OJ31-6　2020/07

Gain-of-function Mutant IKACh Channels as a Pharmacological Target for Bradyarrhythmia(和訳中)

山田 憲明, 朝野 仁裕, 稲野 辺厚, 石綿 紀久, 倉智 嘉久, 北風 政史, 坂田 泰史, 高島 成二

日本循環器学会学術集会抄録集　Vol. 84回　p. OJ31-6　2020/07

Non-Radioactive In Vitro Cardiac Myosin Light Chain Kinase Assays

Kenta Kamikubo, Osamu Tsukamoto, Yuki Uyama-Saito, Ryohei Oya, Tomoya Tsubota, Noboru Fujino, Yoshihiro Asano, Hisakazu Kato, Ken Matsuoka, Seiji Takashima

Journal of Visualized Experiments　No. 160　2020/06/23　Research paper (scientific journal)

Identification of transmembrane protein 168 mutation in familial Brugada syndrome.

Akio Shimizu, Dimitar P Zankov, Akira Sato, Masahiro Komeno, Futoshi Toyoda, Satoru Yamazaki, Toshinori Makita, Taichi Noda, Masahito Ikawa, Yoshihiro Asano, Yohei Miyashita, Seiji Takashima, Hiroshi Morita, Taisuke Ishikawa, Naomasa Makita, Masahito Hitosugi, Hiroshi Matsuura, Seiko Ohno, Minoru Horie, Hisakazu Ogita

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 34　No. 5　p. 6399-6417　2020/05　Research paper (scientific journal)

心不全におけるミオシン調節軽鎖リン酸化の意義

塚本 蔵, 斎藤 侑希, 藤野 陽, 高島 成二, 北風 政史

循環器内科　Vol. 87　No. 4　p. 482-487　2020/04

Mouse skeletal muscle creatine chemical exchange saturation transfer (CrCEST) imaging at 11.7T MRI.

Yusuke Takahashi, Shigeyoshi Saito, Hidetaka Kioka, Rikita Araki, Yoshihiro Asano, Seiji Takashima, Yasushi Sakata, Yoshichika Yoshioka

Journal of magnetic resonance imaging : JMRI　Vol. 51　No. 2　p. 563-570　2020/02　Research paper (scientific journal)

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases.

Kenshi Hayashi, Ryota Teramoto, Akihiro Nomura, Yoshihiro Asano, Manu Beerens, Yasutaka Kurata, Isao Kobayashi, Noboru Fujino, Hiroshi Furusho, Kenji Sakata, Kenji Onoue, David Y Chiang, Tuomas O Kiviniemi, Eva Buys, Patrick Sips, Micah L Burch, Yanbin Zhao, Amy E Kelly, Masanobu Namura, Yoshihito Kita, Taketsugu Tsuchiya, Bunji Kaku, Kotaro Oe, Yuko Takeda, Tetsuo Konno, Masaru Inoue, Takashi Fujita, Takeshi Kato, Akira Funada, Hayato Tada, Akihiko Hodatsu, Chiaki Nakanishi, Yuichiro Sakamoto, Toyonobu Tsuda, Yoji Nagata, Yoshihiro Tanaka, Hirofumi Okada, Keiich Usuda, Shihe Cui, Yoshihiko Saito, Calum A MacRae, Seiji Takashima, Masakazu Yamagishi, Masa-Aki Kawashiri, Masayuki Takamura

Cardiovascular research　Vol. 116　No. 13　p. 2116-2130　2020/01/24　Research paper (scientific journal)

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170

Shohei Yashirogi, Takemasa Nagao, Yuya Nishida, Yusuke Takahashi, Tasneem Qaqorh, Issei Yazawa, Toru Katayama, Hidetaka Kioka, Tsubasa S. Matsui, Shigeyoshi Saito, Yuki Masumura, Osamu Tsukamoto, Hisakazu Kato, Hiromichi Ueda, Osamu Yamaguchi, Kenta Yashiro, Satoru Yamazaki, Seiji Takashima, Yasunori Shintani

EMBO Reports　2020　Research paper (scientific journal)

心臓特異的ミオシン軽鎖キナーゼの機能解明

宇山 侑希, 塚本 蔵, 高島 成二

日本生化学会大会プログラム・講演要旨集　Vol. 92回　p. [1T06m-02]　2019/09

AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.

Hiroshi Asanuma, Hyemoon Chung, Shin Ito, Kyung-Duk Min, Madoka Ihara, Hiroko Takahama, Marina Funayama, Miki Imazu, Hiroki Fukuda, Akiko Ogai, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Toshisuke Morita, Masaru Sugimachi, Masanori Asakura, Masafumi Kitakaze

Cardiovascular drugs and therapy　Vol. 33　No. 3　p. 277-286　2019/06　Research paper (scientific journal)

Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy.

Yusuke Takahashi, Hidetaka Kioka, Yasunori Shintani, Akiko Ohki, Seiji Takashima, Yasushi Sakata, Takahiro Higuchi, Shigeyoshi Saito

Magnetic resonance imaging　Vol. 58　p. 38-43　2019/05　Research paper (scientific journal)

不整脈原性心筋症の原因遺伝子TMEM43の同定とゲノム編集ラットを用いた機能解析

四宮 春輝, 加藤 久和, 渡邉 望, 鶴田 敏博, 高島 成二, 木岡 秀隆, 朝野 仁裕, 坂田 泰史

日本臨床分子医学会学術総会プログラム・抄録集　Vol. 56回　p. 49-49　2019/04

Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy.

Akihiko Hodatsu, Noboru Fujino, Yuki Uyama, Osamu Tsukamoto, Atsuko Imai-Okazaki, Satoru Yamazaki, Osamu Seguchi, Tetsuo Konno, Kenshi Hayashi, Masa-Aki Kawashiri, Yoshihiro Asano, Masafumi Kitakaze, Seiji Takashima, Masakazu Yamagishi

ESC heart failure　Vol. 6　No. 2　p. 406-415　2019/04　Research paper (scientific journal)

Anti-HB-EGF Antibody-Mediated Delivery of siRNA to Atherosclerotic Lesions in Mice.

Shota Tsuchida, Takashi Matsuzaki, Masaki Yamato, Keiji Okuda, Hai Ying Fu, Ryo Araki, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroyuki Hao, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Eisuke Mekada, Tetsuo Minamino

International heart journal　Vol. 59　No. 6　p. 1425-1431　2018/11/28　Research paper (scientific journal)

Physiological and structural analysis of cytochrome c oxidase activating protein Higd1a

Yuya Nishida, Takemasa Nagao, Takaharu Hayashi, Yasunori Shintani, Seiji Takashima

2018/08

Protein carbamylation exacerbates vascular calcification.

Daisuke Mori, Isao Matsui, Akihiro Shimomura, Nobuhiro Hashimoto, Ayumi Matsumoto, Karin Shimada, Satoshi Yamaguchi, Tatsufumi Oka, Keiichi Kubota, Sayoko Yonemoto, Yusuke Sakaguchi, Atsushi Takahashi, Yasunori Shintani, Seiji Takashima, Yoshitsugu Takabatake, Takayuki Hamano, Yoshitaka Isaka

Kidney international　Vol. 94　No. 1　p. 72-90　2018/07　Research paper (scientific journal)

Author Correction: Heart Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy.

Yoji Nagata, Masakazu Yamagishi, Tetsuo Konno, Chiaki Nakanishi, Yoshihiro Asano, Shin Ito, Yuri Nakajima, Osamu Seguchi, Noboru Fujino, Masa-Aki Kawashiri, Seiji Takashima, Masafumi Kitakaze, Kenshi Hayashi

Scientific reports　Vol. 8　No. 1　p. 7768-7768　2018/05/14

心筋細胞においてメカニカルストレスはストレス応答性エンハンサーCR9によるNppb遺伝子発現を促進する(Mechanical stresses activates the stress-responsive enhancer CR9-driven Nppb gene expression in cardiomyocytes)

Miyashita Yohei, Tsukamoto Osamu, Matsuoka Ken, Yashirogi Shohei, Ito Hiroaki, Kioka Hidetaka, Asano Yoshihiro, Kaneko Makoto, Takashima Seiji, Sakata Yasushi

日本法医学雑誌　Vol. 72　No. 1　p. 205-205　2018/05

Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling.

Takashige Tobita, Seitaro Nomura, Takanori Fujita, Hiroyuki Morita, Yoshihiro Asano, Kenji Onoue, Masamichi Ito, Yasushi Imai, Atsushi Suzuki, Toshiyuki Ko, Masahiro Satoh, Kanna Fujita, Atsuhiko T Naito, Yoshiyuki Furutani, Haruhiro Toko, Mutsuo Harada, Eisuke Amiya, Masaru Hatano, Eiki Takimoto, Tsuyoshi Shiga, Toshio Nakanishi, Yasushi Sakata, Minoru Ono, Yoshihiko Saito, Seiji Takashima, Nobuhisa Hagiwara, Hiroyuki Aburatani, Issei Komuro

Scientific reports　Vol. 8　No. 1　p. 1998-1998　2018/01/31　Research paper (scientific journal)

心臓特異的ミオシン軽鎖キナーゼの活性制御機構の解明

宇山 侑希, 塚本 蔵, 高島 成二

生命科学系学会合同年次大会　Vol. 2017年度　p. [3P-0207]　2017/12

mRNA分解制御機構に着目した心筋肥大関連因子の探索

増村 雄喜, 肥後 修一朗, 彦惣 俊吾, 高島 成二, 坂田 泰史

生命科学系学会合同年次大会　Vol. 2017年度　p. [1P-0778]　2017/12

Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts

Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Hiroko Takahama, Yoshiro Shinozaki, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimachi, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 31　No. 5-6　p. 501-510　2017/12　Research paper (scientific journal)

Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy

Yoji Nagata, Masakazu Yamagishi, Tetsuo Konno, Chiaki Nakanishi, Yoshihiro Asano, Shin Ito, Yuri Nakajima, Osamu Seguchi, Noboru Fujino, Masa-aki Kawashiri, Seiji Takashima, Masafumi Kitakaze, Kenshi Hayashi

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/12　Research paper (scientific journal)

Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts

Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Hiroko Takahama, Yoshiro Shinozaki, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimachi, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 31　No. 5-6　p. 501-510　2017/12　Research paper (scientific journal)

Development of Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Cardiomyocytes

Higo Shuichiro, Ishizu Takamaru, Masumura Yuki, Higo Tomoaki, Morimoto Sachio, Takashima Seiji, Hikoso Shungo, Sakata Yasushi

CIRCULATION　Vol. 136　2017/11/14

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda

CELL REPORTS　Vol. 21　No. 7　p. 1824-1838　2017/11　Research paper (scientific journal)

Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.

Kita A, Hino N, Higashi S, Hirota K, Narumi R, Adachi J, Takafuji K, Ishimoto K, Okada Y, Sakamoto K, Tomonaga T, Takashima S, Mizuguchi H, Doi T

Sci Rep.　2017/11　Research paper (scientific journal)

RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity

Masaki Yamato, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino

INTERNATIONAL JOURNAL OF GERONTOLOGY　Vol. 11　No. 3　p. 191-196　2017/09　Research paper (scientific journal)

Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes

Takamaru Ishizu, Shuichiro Higo, Yuki Masumura, Yasuaki Kohama, Mikio Shiba, Tomoaki Higo, Masato Shibamoto, Akito Nakagawa, Sachio Morimoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/08　Research paper (scientific journal)

Cartilage Intermediate Layer Protein 1 Suppresses TGF-beta Signaling in Cardiac Fibroblasts

Kazuhiro Shindo, Masanori Asakura, Kyung-Duk Min, Shin Ito, Hai Ying Fu, Satoru Yamazaki, Ayako Takahashi, Miki Imazu, Hiroki Fukuda, Yuri Nakajima, Hiroshi Asanuma, Tetsuo Minamino, Seiji Takashima, Naoto Minamino, Naoki Mochizuki, Masafumi Kitakaze

INTERNATIONAL JOURNAL OF GERONTOLOGY　Vol. 11　No. 2　p. 67-74　2017/06　Research paper (scientific journal)

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor

Yuri Kotani, Daisuke Morito, Kenshiro Sakata, Shiori Ainuki, Munechika Sugihara, Tomohisa Hatta, Shun-ichiro Iemura, Seiji Takashima, Tohru Natsume, Kazuhiro Nagata

SCIENTIFIC REPORTS　Vol. 7　2017/03　Research paper (scientific journal)

A specific single-stranded DNA induces a distinct conformational change in the nucleoid-associated protein HU

Yuya Nishida, Teppei Ikeya, Tsutomu Mikawa, Jin Inoue, Yutaka Ito, Yasunori Shintani, Ryoji Masui, Seiki Kuramitsu, Seiji Takashima

Biochemistry and Biophysics Reports　Vol. 8　p. 318-324　2016/12/01　Research paper (scientific journal)

Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines

Ayami Kita, Nobumasa Hino, Sakiko Higashi, Kohji Hirota, Ryohei Narumi, Jun Adachi, Kazuaki Takafuji, Kenji Ishimoto, Yoshiaki Okada, Kensaku Sakamoto, Takeshi Tomonaga, Seiji Takashima, Hiroyuki Mizuguchi, Takefumi Doi

SCIENTIFIC REPORTS　Vol. 6　2016/11　Research paper (scientific journal)

心臓特異的ミオシン軽鎖キナーゼ特異的阻害ペプチドの同定

宇山 侑希, 塚本 蔵, 菅 裕明, 高島 成二

日本生化学会大会プログラム・講演要旨集　Vol. 89回　p. [3P-139]　2016/09

Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats

Keiji Okuda, Hai Ying Fu, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Punniyakoti V. Thanikachalam, Tatsuya Fukuta, Tomohiro Asai, Masaki Yamato, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Haruo Hanawa, Hiroyuki Hao, Naoto Oku, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino

PLOS ONE　Vol. 11　No. 8　2016/08　Research paper (scientific journal)

Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy

Shin Ito, Masanori Asakura, Yulin Liao, Kyung-Duk Min, Ayako Takahashi, Kazuhiro Shindo, Satoru Yamazaki, Osamu Tsukamoto, Hiroshi Asanuma, Masaki Mogi, Masatsugu Horiuchi, Yoshihiro Asano, Shoji Sanada, Tetsuo Minamino, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

JOURNAL OF THE AMERICAN HEART ASSOCIATION　Vol. 5　No. 7　2016/07　Research paper (scientific journal)

Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA

Yuki Masumura, Shuichiro Higo, Yoshihiro Asano, Hisakazu Kato, Yi Yan, Saki Ishino, Osamu Tsukamoto, Hidetaka Kioka, Takaharu Hayashi, Yasunori Shintani, Satoru Yamazaki, Tetsuo Minamino, Masafumi Kitakaze, Issei Komuro, Seiji Takashima, Yasushi Sakata

SCIENTIFIC REPORTS　Vol. 6　2016/06　Research paper (scientific journal)

A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure

Machiko Kanzaki, Yoshihiro Asano, Hatsue Ishibashi-Ueda, Eiji Oiki, Tomoki Nishida, Hiroshi Asanuma, Hisakazu Kato, Toru Oka, Tomohito Ohtani, Osamu Tsukamoto, Shuichiro Higo, Hidetaka Kioka, Ken Matsuoka, Yoshiki Sawa, Issei Komuro, Masafumi Kitakaze, Seiji Takashima, Yasushi Sakata

PLOS ONE　Vol. 11　No. 2　2016/02　Research paper (scientific journal)

Neuromuscular regulation in zebrafish by a large AAA plus ATPase/ubiquitin ligase, mysterin/RNF213

Yuri Kotani, Daisuke Morito, Satoru Yamazaki, Kazutoyo Ogino, Koichi Kawakami, Seiji Takashima, Hiromi Hirata, Kazuhiro Nagata

SCIENTIFIC REPORTS　Vol. 5　2015/11　Research paper (scientific journal)

Usefulness and Limitation of Protein Mass Analysis

Seiji Takashima

CIRCULATION JOURNAL　Vol. 79　No. 12　p. 2549-2550　2015/11　Research paper (scientific journal)

Beyond Homozygosity Mapping: Family-Control analysis based on Hamming distance for prioritizing variants in exome sequencing

Atsuko Imai, Akihiro Nakaya, Somayyeh Fahiminiya, Martine Tetreault, Jacek Majewski, Yasushi Sakata, Seiji Takashima, Mark Lathrop, Jurg Ott

SCIENTIFIC REPORTS　Vol. 5　2015/07　Research paper (scientific journal)

Data Mining as a Powerful Tool for Creating Novel Drugs in Cardiovascular Medicine: The Importance of a "Back-and-Forth Loop" Between Clinical Data and Basic Research

Masafumi Kitakaze, Masanori Asakura, Atsushi Nakano, Seiji Takashima, Takashi Washio

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 29　No. 3　p. 309-315　2015/06

Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO

Hiroshi Asanuma, Shoji Sanada, Masanori Asakura, Yoshihiro Asano, Jiyoong Kim, Yoshiro Shinozaki, Hidezo Mori, Tetsuo Minamino, Seiji Takashima, Masafumi Kitakaze

HYPERTENSION RESEARCH　Vol. 37　No. 8　p. 716-723　2014/08　Research paper (scientific journal)

Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas

Shokoufeh Shahrabi-Farahani, Lili Wang, Bernadette M. M. Zwaans, Jeans M. Santana, Akio Shimizu, Seiji Takashima, Michael Kreuter, Leigh Coultas, Patricia A. D'Amore, Jeffrey M. Arbeit, Lars A. Akslen, Diane R. Bielenberg

LABORATORY INVESTIGATION　Vol. 94　No. 7　p. 752-765　2014/07　Research paper (scientific journal)

PDE5 inhibitor efficacy is estrogen dependent in female heart disease

Hideyuki Sasaki, Takahiro Nagayama, Robert M. Blanton, Kinya Seo, Manling Zhang, Guangshuo Zhu, Dong I. Lee, Djahida Bedja, Steven Hsu, Osamu Tsukamoto, Seiji Takashima, Masafumi Kitakaze, Michael E. Mendelsohn, Richard H. Karas, David A. Kass, Eiki Takimoto

JOURNAL OF CLINICAL INVESTIGATION　Vol. 124　No. 6　p. 2464-2471　2014/06　Research paper (scientific journal)

Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart

Ken Matsuoka, Yoshihiro Asano, Shuichiro Higo, Osamu Tsukamoto, Yi Yan, Satoru Yamazaki, Takashi Matsuzaki, Hidetaka Kioka, Hisakazu Kato, Yoshihiro Uno, Masanori Asakura, Hiroshi Asanuma, Tetsuo Minamino, Hiroyuki Aburatani, Masafumi Kitakaze, Issei Komuro, Seiji Takashima

FASEB JOURNAL　Vol. 28　No. 4　p. 1870-1879　2014/04　Research paper (scientific journal)

Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

Yasunori Shintani, Hannes C. A. Drexler, Hidetaka Kioka, Cesare M. N. Terracciano, Steven R. Coppen, Hiromi Imamura, Masaharu Akao, Junichi Nakai, Ann P. Wheeler, Shuichiro Higo, Hiroyuki Nakayama, Seiji Takashima, Kenta Yashiro, Ken Suzuki

EMBO REPORTS　Vol. 15　No. 4　p. 438-445　2014/04　Research paper (scientific journal)

Comprehensive metagenomic approach for detecting causative microorganisms in culture-negative infective endocarditis

Atsuko Imai, Kazuyoshi Gotoh, Yoshihiro Asano, Noriaki Yamada, Daisuke Motooka, Masaki Fukushima, Machiko Kanzaki, Tomohito Ohtani, Yasushi Sakata, Hiroyuki Nishi, Koichi Toda, Yoshiki Sawa, Issei Komuro, Toshihiro Horii, Tetsuya Iida, Shota Nakamura, Seiji Takashima

INTERNATIONAL JOURNAL OF CARDIOLOGY　Vol. 172　No. 2　p. E288-E289　2014/03

Development of LC-MS/MS quantification of the novel antimicrobial peptide, SR-0379, and its pharmacokinetics in rats

Hideki Tomioka, Hironori Nakagami, Tomokazu Sano, Kazuaki Takafuji, Seiji Takashima, Yasufumi Kaneda, Ryuichi Morishita

Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 14　No. 1　p. 26-31　2014　Research paper (scientific journal)

Glucose-stimulated Single Pancreatic Islets Sustain Increased Cytosolic ATP Levels during Initial Ca2+ Influx and Subsequent Ca2+ Oscillations

Takashi Tanaka, Kazuaki Nagashima, Nobuya Inagaki, Hidetaka Kioka, Seiji Takashima, Hajime Fukuoka, Hiroyuki Noji, Akira Kakizuka, Hiromi Imamura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 4　p. 2205-2216　2014/01　Research paper (scientific journal)

Plk1 Phosphorylates CLIP-170 and Regulates Its Binding to Microtubules for Chromosome Alignment

Mai Kakeno, Kenji Matsuzawa, Toshinori Matsui, Hiroki Akita, Ikuko Sugiyama, Fumiyoshi Ishidate, Atsushi Nakano, Seiji Takashima, Hidemasa Goto, Masaki Inagaki, Kozo Kaibuchi, Takashi Watanabe

CELL STRUCTURE AND FUNCTION　Vol. 39　No. 1　p. 45-59　2014　Research paper (scientific journal)

CB1 cannabinoid receptor deficiency promotes cardiac remodeling induced by pressure overload in mice

Yulin Liao, Jianping Bin, Tao Luo, Hui Zhao, Catherine Ledent, Masanori Asakura, Dingli Xu, Seiji Takashima, Masafumi Kitakaze

INTERNATIONAL JOURNAL OF CARDIOLOGY　Vol. 167　No. 5　p. 1936-1944　2013/09　Research paper (scientific journal)

Derivation of a mathematical expression for predicting the time to cardiac events in patients with heart failure: a retrospective clinical study

Akemi Yoshida, Masanori Asakura, Hiroshi Asanuma, Akira Ishii, Takuya Hasegawa, Tetsuo Minamino, Seiji Takashima, Hideaki Kanzaki, Takashi Washio, Masafumi Kitakaze

HYPERTENSION RESEARCH　Vol. 36　No. 5　p. 450-456　2013/05　Research paper (scientific journal)

Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice

Ayako Takahashi, Masanori Asakura, Shin Ito, Kyung-Duk Min, Kazuhiro Shindo, Yi Yan, Yulin Liao, Satoru Yamazaki, Shoji Sanada, Yoshihiro Asano, Hatsue Ishibashi-Ueda, Seiji Takashima, Tetsuo Minamino, Hiroshi Asanuma, Naoki Mochizuki, Masafumi Kitakaze

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 304　No. 10　p. H1361-H1369　2013/05　Research paper (scientific journal)

Decreased mortality associated with statin treatment in patients with acute myocardial infarction and lymphotoxin-alpha C804A polymorphism

Shinichiro Suna, Yasuhiko Sakata, Daisaku Nakatani, Keiji Okuda, Masahiko Shimizu, Masaya Usami, Sen Matsumoto, Masahiko Hara, Kouichi Ozaki, Hiroya Mizuno, Tetsuo Minamino, Seiji Takashima, Masami Nishino, Yasushi Matsumura, Hiroshi Takeda, Toshihiro Tanaka, Hiroshi Sato, Masatsugu Hori, Issei Komuro

ATHEROSCLEROSIS　Vol. 227　No. 2　p. 373-379　2013/04　Research paper (scientific journal)

イヌ心臓において新たに合成したラジカル含有ナノ粒子は一酸化窒素を介して虚血再灌流傷害後の心保護を増大させる(Novel Synthesized Radical-containing Nanoparticles Augment Cardioprotection after Ischemia-reperfusion Injury via Nitric Oxide in Canine Hearts)

Yoshida Akemi, Asanuma Hiroshi, Sanada Shoji, Sasaki Hideyuki, Takahama Hiroyuki, Asakura Masanori, Minamino Tetsuo, Takashima Seiji, Mochizuki Naoki, Kitakaze Masafumi

Circulation Journal　Vol. 77　No. Suppl.I　p. 141-141　2013/03

Ablation of Rnf213 retards progression of diabetes in the Akita mouse

Hatasu Kobayashi, Satoru Yamazaki, Seiji Takashima, Wanyang Liu, Hiroko Okuda, Junxia Yan, Yukiko Fujii, Toshiaki Hitomi, Kouji H. Harada, Toshiyuki Habu, Akio Koizumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 432　No. 3　p. 519-525　2013/03　Research paper (scientific journal)

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons

Yasunori Shintani, Amar Kapoor, Masahiro Kaneko, Ryszard T. Smolenski, Fulvio D'Acquisto, Steven R. Coppen, Narumi Harada-Shoji, Hack Jae Lee, Christoph Thiemermann, Seiji Takashima, Kenta Yashiro, Ken Suzuki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 110　No. 13　p. 5109-5114　2013/03　Research paper (scientific journal)

Deficiency of type 1 cannabinoid receptors worsens acute heart failure induced by pressure overload in mice

Yulin Liao, Jianping Bin, Masanori Asakura, Wanling Xuan, Baihe Chen, Qiaobing Huang, Dingli Xu, Catherine Ledent, Seiji Takashima, Masafumi Kitakaze

EUROPEAN HEART JOURNAL　Vol. 33　No. 24　p. 3124-3133　2012/12　Research paper (scientific journal)

LKB1 and AMP-activated protein kinase: regulators of cell polarity

Atsushi Nakano, Seiji Takashima

GENES TO CELLS　Vol. 17　No. 9　p. 737-747　2012/09

Increased Smooth Muscle Contractility in Mice Deficient for Neuropilin 2

Diane R. Bielenberg, Abhishek Seth, Akio Shimizu, Kristine Pelton, Vivian Cristofaro, Aruna Ramachandran, Bernadette M. M. Zwaans, Cheng Chen, Ramaswamy Krishnan, Meetu Seth, Lin Huang, Seiji Takashima, Michael Klagsbrun, Maryrose P. Sullivan, Rosalyn M. Adam

AMERICAN JOURNAL OF PATHOLOGY　Vol. 181　No. 2　p. 548-559　2012/08　Research paper (scientific journal)

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer

Kaoru Nishikawa, Tomohiro Asai, Hirokazu Shigematsu, Kosuke Shimizu, Hisakazu Kato, Yoshihiro Asano, Seiji Takashima, Eisuke Mekada, Naoto Oku, Tetsuo Minamino

JOURNAL OF CONTROLLED RELEASE　Vol. 160　No. 2　p. 274-280　2012/06　Research paper (scientific journal)

H-2 Mediates Cardioprotection Via Involvements of K-ATP Channels and Permeability Transition Pores of Mitochondria in Dogs

Akemi Yoshida, Hiroshi Asanuma, Hideyuki Sasaki, Shoji Sanada, Satoru Yamazaki, Yoshihiro Asano, Yoshiro Shinozaki, Hidezo Mori, Akito Shimouchi, Motoaki Sano, Masanori Asakura, Tetsuo Minamino, Seiji Takashima, Masaru Sugimachi, Naoki Mochizuki, Masafumi Kitakaze

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 26　No. 3　p. 217-226　2012/06　Research paper (scientific journal)

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils

Hong-Beom Bae, Jaroslaw W. Zmijewski, Jessy S. Deshane, Jean-Marc Tadie, David D. Chaplin, Seiji Takashima, Edward Abraham

FASEB JOURNAL　Vol. 25　No. 12　p. 4358-4368　2011/12　Research paper (scientific journal)

ATF6 beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18

Masahiro Yamamoto, Ji Su Ma, Christina Mueller, Naganori Kamiyama, Hiroyuki Saiga, Emi Kubo, Taishi Kimura, Toru Okamoto, Megumi Okuyama, Hisako Kayama, Kisaburo Nagamune, Seiji Takashima, Yoshiharu Matsuura, Dominique Soldati-Favre, Kiyoshi Takeda

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 208　No. 7　p. 1533-1546　2011/07　Research paper (scientific journal)

Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura, Satoru Yamazaki, Atsushi Toyoda, Ken-ichiro Kikuta, Yasushi Takagi, Kouji H. Harada, Asao Fujiyama, Roman Herzig, Boris Krischek, Liping Zou, Jeong Eun Kim, Masafumi Kitakaze, Susumu Miyamoto, Kazuhiro Nagata, Nobuo Hashimoto, Akio Koizumi

PLOS ONE　Vol. 6　No. 7　2011/07　Research paper (scientific journal)

AMP-kinase regulates the speed of microtubule polymerization and cell polarity by phosphorylation of microtubule plus end protein CLIP-170

Seiji Takashima

Seikagaku　Vol. 83　No. 9　p. 850-854　2011　Research paper (scientific journal)

A histamine H-2 receptor blocker ameliorates development of heart failure in dogs independently of beta-adrenergic receptor blockade

Hiroyuki Takahama, Hiroshi Asanuma, Shoji Sanada, Masashi Fujita, Hideyuki Sasaki, Masakatsu Wakeno, Jiyoong Kim, Masanori Asakura, Seiji Takashima, Tetsuo Minamino, Kazuo Komamura, Masaru Sugimachi, Masafumi Kitakaze

BASIC RESEARCH IN CARDIOLOGY　Vol. 105　No. 6　p. 787-794　2010/11　Research paper (scientific journal)

Isoform-specific Intermolecular Disulfide Bond Formation of Heterochromatin Protein 1 (HP1)

Shuichiro Higo, Yoshihiro Asano, Hisakazu Kato, Satoru Yamazaki, Atsushi Nakano, Osamu Tsukamoto, Osamu Seguchi, Mitsutoshi Asai, Masanori Asakura, Hiroshi Asanuma, Shoji Sanada, Tetsuo Minamino, Issei Komuro, Masafumi Kitakaze, Seiji Takashima

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 41　p. 31337-31347　2010/10　Research paper (scientific journal)

Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload

Hai Ying Fu, Ken-ichiro Okada, Yulin Liao, Osamu Tsukamoto, Tadashi Isomura, Mitsutoshi Asai, Tamaki Sawada, Keiji Okuda, Yoshihiro Asano, Shoji Sanada, Hiroshi Asanuma, Masanori Asakura, Seiji Takashima, Issei Komuro, Masafumi Kitakaze, Tetsuo Minamino

CIRCULATION　Vol. 122　No. 4　p. 361-U93　2010/07　Research paper (scientific journal)

Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding

Miki Hamaoka, Ichino Chinen, Takuya Murata, Seiji Takashima, Ryo Iwamoto, Eisuke Mekada

JOURNAL OF BIOCHEMISTRY　Vol. 148　No. 1　p. 55-69　2010/07　Research paper (scientific journal)

X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes

Tamaki Sawada, Tetsuo Minamino, Hai Ying Fu, Mitsutoshi Asai, Keiji Okuda, Tadashi Isomura, Satoru Yamazaki, Yoshihiro Asano, Ken-ichiro Okada, Osamu Tsukamoto, Shoji Sanada, Hiroshi Asanuma, Masanori Asakura, Seiji Takashima, Masafumi Kitakaze, Issei Komuro

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 48　No. 6　p. 1280-1289　2010/06　Research paper (scientific journal)

Antihypertrophic effects of adiponectin on cardiomyocytes are associated with the inhibition of heparin-binding epidermal growth factor signaling

Yulin Liao, Wanling Xuan, Jing Zhao, Jianpin Bin, Hui Zhao, Masanori Asakura, Tohru Funahashi, Seiji Takashima, Masafumi Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 393　No. 3　p. 519-525　2010/03　Research paper (scientific journal)

Identification of Genes related to Heart Failure Using Global Gene Expression Profiling of Human Failing Myocardium.

Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M

Biochem Biophys Res Commun.　2010/02　Research paper (scientific journal)

Methamphetamine directly accelerates beating rate in cardiomyocytes by increasing Ca2+ entry via L-type Ca2+ channel

Kana Sugimoto, Ko Okamura, Hidekazu Tanaka, Seiji Takashima, Hiroshi Ochi, Takuma Yamamoto, Ryoji Matoba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 390　No. 4　p. 1214-1220　2009/12　Research paper (scientific journal)

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3

Masahiro Yamamoto, Daron M. Standley, Seiji Takashima, Hiroyuki Saiga, Megumi Okuyama, Hisako Kayama, Emi Kubo, Hiroshi Ito, Mutsumi Takaura, Tadashi Matsuda, Dominique Soldati-Favre, Kiyoshi Takeda

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 206　No. 12　p. 2747-2760　2009/11　Research paper (scientific journal)

Extracellular protein kinase CK2 is a novel associating protein of Neuropilin-1

Yasunori Shintani, Seiji Takashima, Hisakazu Kato, Kazuo Komamura, Masafumi Kitakaze

Biochemical and Biophysical Research Communications　Vol. 385　No. 4　p. 618-623　2009/08/07　Research paper (scientific journal)

Metformin Prevents Progression of Heart Failure in Dogs Role of AMP-Activated Protein Kinase

Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masakatsu Wakeno, Shin Ito, Akiko Ogai, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Masaru Sugimachi, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze

CIRCULATION　Vol. 119　No. 19　p. 2568-U74　2009/05　Research paper (scientific journal)

FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F.

Yamauchi K, Mizushima S, Tamada A, Yamamoto N, Takashima S, Murakami F

J Neurosci.　2009/04　Research paper (scientific journal)

PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts

Mitsutoshi Asai, Osamu Tsukamoto, Tetsuo Minamino, Hiroshi Asanuma, Masashi Fujita, Yoshihiro Asano, Hiroyuki Takahama, Hideyuki Sasaki, Shuichiro Higo, Masanori Asakura, Seiji Takashima, Masatsugu Hori, Masafumi Kitakaze

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 46　No. 4　p. 452-462　2009/04　Research paper (scientific journal)

Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats

Hiroyuki Takahama, Tetsuo Minamino, Hiroshi Asanuma, Masashi Fujita, Tomohiro Asai, Masakatsu Wakeno, Hideyuki Sasaki, Hiroshi Kikuchi, Kouichi Hashimoto, Naoto Oku, Masanori Asakura, Jiyoong Kim, Seiji Takashima, Kazuo Komamura, Masaru Sugimachi, Naoki Mochizuki, Masafumi Kitakaze

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　Vol. 53　No. 8　p. 709-717　2009/02　Research paper (scientific journal)

Phosphorylation of Myosin Regulatory Light Chain by Myosin Light Chain Kinase, and Muscle Contraction

Seiji Takashima

CIRCULATION JOURNAL　Vol. 73　No. 2　p. 208-213　2009/02

Lymphotoxin-alpha 3 mediates monocyte-endothelial interaction by TNFR I/NF-kappa B signaling

Shinichiro Suna, Yasuhiko Sakata, Masahiko Shimizu, Daisaku Nakatani, Masaya Usami, Sen Matsumoto, Hiroya Mizuno, Kouichi Ozaki, Seiji Takashima, Hiroshi Takeda, Toshihiro Tanaka, Masatsugu Hori, Hiroshi Sato

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 379　No. 2　p. 374-378　2009/02　Research paper (scientific journal)

Alpha 1 antitrypsin activity is decreased in human amnion in premature rupture of the fetal membranes

Noriko Izumi-Yoneda, Ayaka Toda, Motonori Okabe, Chika Koike, Seiji Takashima, Toshiko Yoshida, Ikuo Konishi, Shigeru Saito, Toshio Nikaido

MOLECULAR HUMAN REPRODUCTION　Vol. 15　No. 1　p. 49-57　2009/01　Research paper (scientific journal)

Ubipuitin-Proteasome System Impairment Caused by a Missense Cardiac Myosin-binding Protein C Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy

Udin Bahrudin, Hiroko Morisaki, Takayuki Morisaki, Haruaki Ninomiya, Katsumi Higaki, Eiji Nanba, Osamu Igawa, Seiji Takashima, Einosuke Mizutas, Junichiro Miake, Yasutaka Yamamoto, Yasuaki Shirayoshi, Masafumi Kitakaze, Lucie Carrier, Ichiro Hisatome

JOURNAL OF MOLECULAR BIOLOGY　Vol. 384　No. 4　p. 896-907　2008/12　Research paper (scientific journal)

Inhibition of Cardiac Remodeling by Pravastatin Is Associated with Amelioration of Endoplasmic Reticulum Stress

Hui Zhao, Yulin Liao, Tetsuo Minamino, Yoshihiro Asano, Masanori Asakura, Jiyoong Kim, Hiroshi Asanuma, Seiji Takashima, Masatsugu Hori, Masafumi Kitakaze

HYPERTENSION RESEARCH　Vol. 31　No. 10　p. 1977-1987　2008/10　Research paper (scientific journal)

Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition

Hai Ying Fu, Tetsuo Minamino, Osamu Tsukamoto, Tamaki Sawada, Mitsutoshi Asai, Hisakazu Kato, Yoshihiro Asano, Masashi Fujita, Seiji Takashima, Masatsugu Hori, Masafumi Kitakaze

CARDIOVASCULAR RESEARCH　Vol. 79　No. 4　p. 600-610　2008/09　Research paper (scientific journal)

Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by Lymphotoxin alpha: DNA microarray analysis

Shinichiro Suna, Yasuhiko Sakata, Hiroshi Sato, Hiroya Mizuno, Daisaku Nakatani, Masahiko Shimizu, Masaya Usami, Seiji Takashima, Hiroshi Takeda, Masatsugu Hori

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　Vol. 15　No. 3　p. 160-165　2008/06　Research paper (scientific journal)

Higher mortality in heterozygous neuropilin-1 mice after cardiac pressure overload

Fei Li, Hui Zhao, Yulin Liao, Seiji Takashima, Yoshihiro Asano, Yasunori Shintani, Masatsugu Hori, Masafumi Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 370　No. 2　p. 317-321　2008/05　Research paper (scientific journal)

[Myosin kinase and sarcomere structure in the heart].

Takashima S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 53　No. 6　p. 701-709　2008/05

Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface

Keisuke Ito, Takahiko Kawasaki, Seiji Takashima, Ikuo Matsuda, Atsu Aiba, Tatsumi Hirata

JOURNAL OF NEUROSCIENCE　Vol. 28　No. 17　p. 4414-4422　2008/04　Research paper (scientific journal)

Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation

Yulin Liao, Hui Zhao, Akiko Ogai, Hisakazu Kato, Masanori Asakura, Jiyoong Kim, Hiroshi Asanuma, Tetsuo Minamino, Seiji Takashima, Masafumi Kitakaze

HYPERTENSION RESEARCH　Vol. 31　No. 2　p. 335-344　2008/02　Research paper (scientific journal)

Identification of p32 as a novel substrate for ATM in heart

Hisakazu Kato, Seiji Takashima, Yoshihiro Asano, Yasunori Shintani, Satoru Yamazaki, Osamu Seguchi, Hiroyuki Yamamoto, Atsushi Nakano, Shuichiro Higo, Akiko Ogai, Tetsuo Minamino, Masafumi Kitakaze, Masatsugu Hori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 366　No. 4　p. 885-891　2008/02　Research paper (scientific journal)

Identification of a novel substrate for TNF alpha-induced kinase NUAK2

Hiroyuki Yamamoto, Seiji Takashima, Yasunori Shintani, Satoru Yamazaki, Osamu Seguchi, Atsushi Nakano, Shuichiro Higo, Hisakazu Kato, Yulin Liao, Yoshihiro Asano, Tetsuo Minamino, Yasushi Matsumura, Hiroshi Takeda, Masafumi Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 365　No. 3　p. 541-547　2008/01　Research paper (scientific journal)

Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis

Makoto Nishida, Toshiki Moriyama, Kouki Ishii, Seiji Takashima, Kazuyuki Yoshizaki, Yoshiro Sugita, Keiko Yamauchi-Takihara

CLINICA CHIMICA ACTA　Vol. 384　No. 1-2　p. 99-104　2007/09　Research paper (scientific journal)

Miglitol, a Novel Alpha-glucosidase inhibitor, Improves Left Ventricular Function in Pacing-induced Heart Failure

Tetsuo Minamino, Masashi Fujita, Kazuo Komamura, Hiroyuki Takahama, Masafumi Kitakaze, Hiroshi Asanuma, Seiji Takashima, Toshiro Matsuda, Masanori Asakura, Toshinao Kurihara, Jiyoong Kim, Hideyuki Sasaki

Journal of Cardiac Failure　Vol. 13　2007/08/01

S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts

Hiroshi Asanuma, Kunihiko Nakai, Shoji Sanada, Tetsuo Minamino, Seiji Takashima, Hisakazu Ogita, Masashi Fujita, Akio Hirata, Masakatsu Wakeno, Hiroyuki Takahama, Jiyoong Kim, Masanori Asakura, Ichiro Sakuma, Akira Kitabatake, Masatsugu Hori, Kazuo Komamura, Masafumi Kitakaze

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 42　No. 5　p. 924-930　2007/05　Research paper (scientific journal)

[HB-EGF therapy for chronic heart failure].

Takashima S, Hori M

Nihon rinsho. Japanese journal of clinical medicine　Vol. 65 Suppl 5　p. 588-593　2007/05

Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats.

Wakeno, M, Minamino, T, Seguchi, O, Okazaki, H, Tsukamoto, O, Okada, K, Hirata, A, Fujita, M, Asanuma, H, Kim, J, Komamura, K, Takashima, S, Mochizuki, N, Kitakaze, M

Circulation　2007/04　Research paper (scientific journal)

Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning

Masashi Fujita, Hiroshi Asanuma, Akio Hirata, Masakatsu Wakeno, Hiroyuki Takahama, Hideyuki Sasaki, Jiyoong Kim, Seiji Takashima, Osamu Tsukamoto, Tetsuo Minamino, Yoshiro Shinozaki, Hitonobu Tomoike, Masatsugu Hori, Masafumi Kitakaze

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 292　No. 4　p. H2004-H2008　2007/04　Research paper (scientific journal)

持続性高頻度心房ペーシングによるイヌ心不全の病態生理におけるヒスタミンH2受容体の新しい役割(A Novel Role of Histamine H2 Receptors in the Pathophysiology of Canine Heart Failure Induced by Sustained Rapid Pacing)

Takahama Hiroyuki, Asanuma Hiroshi, Asakura Masanori, Kimu Chiyun, Fujita Masashi, Hirata Akio, Wakeno Masakatsu, Sasaki Hideyuki, Takashima Seiji, Minamino Tetsuo, Komamura Kazuo, Mochizuki Naoki, Kitakaze Masafumi

Circulation Journal　Vol. 71　No. Suppl.I　p. 316-316　2007/03

HB-EGF, transactivation, and cardiac hypertrophy

Seiji Takashima, Masafumi Kitakaze

International Journal of Gerontology　Vol. 1　No. 1　p. 2-9　2007

Blockade of angiotensin II receptors reduces the expression of receptors for advanced glycation end products in human endothelial cells

Masashi Fujita, Hiroko Okuda, Osamu Tsukamoto, Yoshihiro Asano, Yulin Liao, Akio Hirata, Jiyoong Kim, Takeshi Miyatsuka, Seiji Takashima, Tetsuo Minamino, Hitonobu Tomoike, Masafumi Kitakaze

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 26　No. 10　p. E138-E142　2006/10　Research paper (scientific journal)

Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats

Masakatsu Wakeno, Tetsuo Minamino, Osamu Seguchi, Hidetoshi Okazaki, Osamu Tsukamoto, Ken-ichiro Okada, Akio Hirata, Masashi Fujita, Hiroshi Asanuma, Jiyoong Kim, Kazuo Komamura, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

CIRCULATION　Vol. 114　No. 18　p. 1923-1932　2006/10　Research paper (scientific journal)

Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs

A Hirata, T Minammo, H Asanuma, M Fujita, M Wakeno, M Myoishi, O Tsukamoto, K Okada, H Koyama, K Komamura, S Takashima, Y Shinozaki, H Mori, M Shiraga, M Kitakaze, M Hori

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　Vol. 48　No. 1　p. 176-184　2006/07　Research paper (scientific journal)

Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

Yasunori Shintani, Seiji Takashima, Yoshihiro Asano, Hisakazu Kato, Yulin Liao, Satoru Yamazaki, Osamu Tsukamoto, Osamu Seguchi, Hiroyuki Yamamoto, Tomi Fukushima, Kazuyuki Sugahara, Masafumi Kitakaze, Masatsugu Hori

EMBO JOURNAL　Vol. 25　No. 13　p. 3045-3055　2006/07　Research paper (scientific journal)

Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via phosphatidylinositol-3-kinase/akt pathway in canine hearts

Hiroyuki Takahama, Tetsuo Minamino, Akio Hirata, Akiko Ogai, Hiroshi Asanuma, Masashi Fujita, Masakatsu Wakeno, Osamu Tsukamoto, Ken-ichiro Okada, Kazuo Komamura, Seiji Takashima, Yoshiro Shinozaki, Hidezo Mori, Naoki Mochizuki, Masafumi Kitakaze

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 20　No. 3　p. 159-165　2006/06　Research paper (scientific journal)

Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs

Hiroshi Asanuma, Tetsuo Minamino, Akiko Ogai, Jiyoong Kim, Masanori Asakura, Kazuo Komamura, Shoji Sanada, Masashi Fujita, Akio Hirata, Masakatsu Wakeno, Osamu Tsukamoto, Yoshiro Shinozaki, Masafumi Myoishi, Seiji Takashima, Hitonobu Tomoike, Masafumi Kitakaze

Journal of Molecular and Cellular Cardiology　Vol. 40　No. 5　p. 666-674　2006/05　Research paper (scientific journal)

Angiotensin II type 1 receptor blocker prevents atrial structural remodeling in rats with hypertension induced by chronic nitric oxide inhibition

Hidetoshi Okazaki, Tetsuo Minamino, Osamu Tsukamoto, Jiyoong Kim, Ken-Ichiro Okada, Masafumi Myoishi, Masakatsu Wakeno, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

Hypertension Research　Vol. 29　No. 4　p. 277-284　2006/04　Research paper (scientific journal)

The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats

O Tsukamoto, T Minamino, S Sanada, K Okada, A Hirata, M Fujita, Y Shintani, L Yulin, Y Asano, S Takashima, S Yamasaki, H Tomoike, M Hori, M Kitakaze

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 20　No. 2　p. 93-102　2006/04　Research paper (scientific journal)

Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice

YL Liao, S Takashima, H Zhao, Y Asano, Y Shintani, T Minamino, J Kim, M Fujita, M Hori, M Kitakaze

CARDIOVASCULAR RESEARCH　Vol. 70　No. 1　p. 107-116　2006/04　Research paper (scientific journal)

顆粒球コロニー刺激因子はホスファチジルイノシトール-3-キナーゼ/Akt経路を介して虚血/再灌流傷害に対する心保護作用を介在する:In vitro心筋細胞及びin vivoイヌ心臓を用いた評価(Granulocyte Colony-Stimulating Factor Mediates Cardioprotection against Ischemia/Reperfusion Injury via Phosphatidylinositol-3-Kinase/Akt Pathway: Evaluation in Vitro Cardiomyocytes and in Vivo Canine Hearts)

Takahama Hiroyuki, Hirata Akio, Minamino Tetsuo, Asanuma Hiroshi, Fujita Masashi, Wakeno Masakatsu, Komamura Kazuo, Tsukamoto Osamu, Okada Kenichiro, Takashima Seiji, Mochizuki Naoki, Kitakaze Masafumi

Circulation Journal　Vol. 70　No. Suppl.I　p. 314-314　2006/03

Neuropilins in neoplasms: Expression, regulation, and function

DR Bielenberg, CA Pettaway, S Takashima, M Klagsbrun

EXPERIMENTAL CELL RESEARCH　Vol. 312　No. 5　p. 584-593　2006/03

Depression of proteasome activities during the progression of cardiac dysfunction in pressure-overloaded heart of mice

O Tsukamoto, T Minamino, K Okada, Y Shintani, S Takashima, H Kato, YL Liao, H Okazaki, M Asai, A Hirata, M Fujita, Y Asano, S Yamazaki, H Asanuma, M Hori, M Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 340　No. 4　p. 1125-1133　2006/02　Research paper (scientific journal)

A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart

O Tsukamoto, H Asanuma, J Kim, T Minamino, S Takashima, A Ogai, A Hirata, M Fujita, Y Shinozaki, H Mori, H Tomoike, M Hori, M Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 338　No. 3　p. 1460-1466　2005/12　Research paper (scientific journal)

Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism

YL Liao, S Takashima, N Maeda, N Ouchi, K Komamura, Shimomura, I, M Hori, Y Matsuzawa, T Funahashi, M Kitakaze

CARDIOVASCULAR RESEARCH　Vol. 67　No. 4　p. 705-713　2005/09　Research paper (scientific journal)

Plexin-A4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance

F Suto, K Ito, M Uemura, M Shimizu, Y Shinkawa, M Sanbo, T Shinoda, M Tsuboi, S Takashima, T Yagi, H Fujisawa

JOURNAL OF NEUROSCIENCE　Vol. 25　No. 14　p. 3628-3637　2005/04　Research paper (scientific journal)

Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model

Y Li, T Minamino, O Tsukamoto, T Yujiri, Y Shintani, K Okada, Y Nagamachi, M Fujita, A Hirata, S Sanada, H Asanuma, S Takashima, M Hori, GL Johnson, M Kitakaze

CIRCULATION　Vol. 111　No. 13　p. 1672-1678　2005/04　Research paper (scientific journal)

Benidipine, a long-acting calcium channel blocker, inhibits cardiac remodeling in pressure-overloaded mice

YL Liao, M Asakura, S Takashima, A Ogai, Y Asano, H Asanuma, T Minamino, H Tomoike, M Hori, M Kitakaze

CARDIOVASCULAR RESEARCH　Vol. 65　No. 4　p. 879-888　2005/03　Research paper (scientific journal)

Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation

YL Liao, M Asakura, S Takashima, H Kato, Y Asano, Y Shintani, T Minamino, H Tomoike, M Hori, M Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 327　No. 4　p. 1083-1087　2005/02　Research paper (scientific journal)

Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts

A Hirata, T Minamino, H Asanuma, S Sanada, M Fujita, O Tsukamoto, M Wakeno, M Myoishi, K Okada, H Koyama, K Komamura, S Takashima, Y Shinozaki, H Mori, H Tomoike, M Hori, M Kitakaze

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 19　No. 1　p. 33-40　2005/01　Research paper (scientific journal)

Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts

M Fujita, T Minamino, S Sanada, H Asanuma, A Hirata, H Ogita, K Okada, O Tsukamoto, S Takashima, H Tomoike, K Node, M Hori, M Kitakaze

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 37　No. 6　p. 1219-1223　2004/12　Research paper (scientific journal)

Opening of Ca2+-activated K+ channels is involved in ischemic preconditioning in canine hearts

Y Shintani, K Node, H Asanuma, S Sanada, S Takashima, Y Asano, YL Liao, M Fujita, A Hirata, Y Shinozaki, T Fukushima, Y Nagamachi, H Okuda, J Kim, H Tomoike, M Hori, M Kitakaze

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 37　No. 6　p. 1213-1218　2004/12　Research paper (scientific journal)

Optimal windows of statin use for immediate infarct limitation - 5 '-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase

S Sanada, H Asanuma, T Minamino, K Node, S Takashima, H Okuda, Y Shinozaki, A Ogai, M Fujita, A Hirata, JY Kim, Y Asano, H Mori, H Tomoike, S Kitamura, M Hori, M Kitakaze

CIRCULATION　Vol. 110　No. 15　p. 2143-2149　2004/10　Research paper (scientific journal)

Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice

YL Liao, M Asakura, S Takashima, A Ogai, Y Asano, Y Shintani, T Minamino, H Asanuma, S Sanada, J Kim, S Kitamura, H Tomoike, M Hori, M Kitakaze

CIRCULATION　Vol. 110　No. 6　p. 692-699　2004/08　Research paper (scientific journal)

Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction - Possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis

K Okada, T Minamino, Y Tsukamoto, YL Liao, O Tsukamoto, S Takashima, A Hirata, M Fujita, Y Nagamachi, T Nakatani, C Yutani, K Ozawa, S Ogawa, H Tomoike, M Hori, M Kitakaze

CIRCULATION　Vol. 110　No. 6　p. 705-712　2004/08　Research paper (scientific journal)

Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C

S Sanada, H Asanuma, O Tsukamoto, T Minamino, K Node, S Takashima, T Fukushima, A Ogai, Y Shinozaki, M Fujita, A Hirata, H Okuda, H Shimokawa, H Tomoike, M Hori, M Kitakaze

CIRCULATION　Vol. 110　No. 1　p. 51-57　2004/07　Research paper (scientific journal)

Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: Role of phosphatidylinositol 3-kinase/Akt pathway

H Ogita, K Node, H Asanuma, S Sanada, J Kim, S Takashima, T Minamino, M Hori, M Kitakaze

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY　Vol. 43　No. 6　p. 821-829　2004/06　Research paper (scientific journal)

b-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine hearts

H Asanuma, T Minamino, S Sanada, S Takashima, H Ogita, A Ogai, M Asakura, YL Liao, Y Asano, Y Shintani, J Kim, Y Shinozaki, H Mori, K Node, S Kitamura, H Tomoike, M Hori, M Kitakaze

CIRCULATION　Vol. 109　No. 22　p. 2773-2779　2004/06　Research paper (scientific journal)

Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts

H Asanuma, S Sanada, A Ogai, T Minamino, S Takashima, M Asakura, H Ogita, Y Shinozaki, H Mori, K Node, H Tomoike, M Hori, M Kitakaze

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY　Vol. 43　No. 4　p. 574-579　2004/04　Research paper (scientific journal)

Raloxifene prevents cardiac hypertrophy and dysfunction in pressure-overloaded mice

H Ogita, K Node, YL Liao, F Ishikura, S Beppu, H Asanuma, S Sanada, S Takashima, T Minamino, M Hori, M Kitakaze

HYPERTENSION　Vol. 43　No. 2　p. 237-242　2004/02　Research paper (scientific journal)

Pharmacological role of HB-EGF shedding by angiotensin II in cardiomyocytes

Seiji Takashima

Folia Pharmacologica Japonica　Vol. 124　No. 2　p. 69-75　2004

A calcium channel blocker activates both ecto-5'-nucleotidase and NO synthase in HUVEC

Y Asano, J Kim, A Ogai, S Takashima, Y Shintani, T Minamino, S Kitamura, H Tomoike, M Hori, M Kitakaze

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 311　No. 3　p. 625-628　2003/11　Research paper (scientific journal)

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

S Yamazaki, R Iwamoto, K Saeki, M Asakura, S Takashima, A Yamazaki, R Kimura, H Mizushima, H Moribe, S Higashiyama, M Endoh, Y Kaneda, S Takagi, S Itami, N Takeda, G Yamada, E Mekada

JOURNAL OF CELL BIOLOGY　Vol. 163　No. 3　p. 469-475　2003/11　Research paper (scientific journal)

Activation of adenosine A(1) receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model

YL Liao, S Takashima, Y Asano, M Asakura, A Ogai, Y Shintani, T Minamino, H Asanuma, S Sanada, J Kim, H Ogita, H Tomoike, M Hori, M Kitakaze

CIRCULATION RESEARCH　Vol. 93　No. 8　p. 759-766　2003/10　Research paper (scientific journal)

Canine DNA array as a potential tool for combining physiology and molecular biology - An application for the gene expression profile of regional ischemic myocardium

M Asakura, S Takashima, Y Asano, T Honma, H Asanuma, S Sanada, Y Shintani, YL Liao, J Kim, H Ogita, K Node, T Minamino, R Yorikane, A Agai, S Kitamura, H Tomoike, M Hori, M Kitakaze

CIRCULATION JOURNAL　Vol. 67　No. 9　p. 788-792　2003/09　Research paper (scientific journal)

Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts

H Ogita, K Node, H Asanuma, S Sanada, S Takashima, T Minamino, M Soma, J Kim, M Hori, F Kitakaze

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY　Vol. 41　No. 6　p. 964-969　2003/06　Research paper (scientific journal)

[Cardiac transplantation].

Yamamoto K, Takashima S, Masuyama T

Nihon rinsho. Japanese journal of clinical medicine　Vol. 61　No. 5　p. 845-850　2003/05

Celiprolol increases coronary blood flow and reduces severity of myocardial ischemia via nitric oxide release

H Asanuma, K Node, T Minamino, S Sanada, S Takashima, Y Ueda, Y Sakata, M Asakura, J Kim, H Ogita, M Lada, M Hori, M Kitakaze

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY　Vol. 41　No. 4　p. 499-505　2003/04　Research paper (scientific journal)

Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats

S Sanada, K Node, T Minamino, S Takashima, A Ogai, H Asanuma, H Ogita, YL Liao, M Asakura, J Kim, M Hori, M Kitakaze

HYPERTENSION　Vol. 41　No. 4　p. 963-967　2003/04　Research paper (scientific journal)

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

R Iwamoto, S Yamazaki, M Asakura, S Takashima, H Hasuwa, K Miyado, S Adachi, M Kitakaze, K Hashimoto, G Raab, D Nanba, S Higashiyama, M Hori, M Klagsbrun, E Mekada

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 100　No. 6　p. 3221-3226　2003/03　Research paper (scientific journal)

[Opening of ATP-sensitive potassium channel attenuates cardiac remodeling induced by chronic inhibition of nitric oxide synthesis].

Sanada S, Node K, Asanuma H, Ogita H, Takashima S, Minamino T, Asakura M, Hori M, Kitakaze M

Journal of cardiology　Vol. 41　No. 1　p. 43-44　2003/01

Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart

H Ogita, K Node, H Asanuma, S Sanada, YL Liao, S Takashima, M Asakura, H Mori, Y Shinozaki, M Hori, M Kitakaze

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　Vol. 40　No. 5　p. 998-1005　2002/09　Research paper (scientific journal)

Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis - Role of 70-kDa S6 kinase and extracellular signal-regulated kinase

S Sanada, K Node, H Asanuma, H Ogita, S Takashima, T Minamino, M Asakura, WL Liao, A Ogai, J Kim, M Hori, M Kitakaze

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　Vol. 40　No. 5　p. 991-997　2002/09　Research paper (scientific journal)

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers synergistically increase coronary blood flow in canine ischemic myocardium - Role of bradykinin

M Kitakaze, H Asanuma, H Funaya, K Node, S Takashima, S Sanada, M Asakura, H Ogita, J Kim, M Hori

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　Vol. 40　No. 1　p. 162-166　2002/07　Research paper (scientific journal)

Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: necropsy validation

YL Liao, F Ishikura, S Beppu, M Asakura, S Takashima, H Asanuma, S Sanada, J Kim, H Ogita, T Kuzuya, K Node, M Kitakaze, M Hori

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 282　No. 5　p. H1703-H1708　2002/05　Research paper (scientific journal)

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

S Takashima, M Kitakaze, M Asakura, H Asanuma, S Sanada, F Tashiro, H Niwa, J Miyazaki, S Hirota, Y Kitamura, T Kitsukawa, H Fujisawa, M Klagsbrun, M Hori

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 99　No. 6　p. 3657-3662　2002/03　Research paper (scientific journal)

A novel signaling pathway in GPCR-mediated cardiac hypertrophy

S Takashima, M Asakura, M Kitakaze, M Hori

ADVANCES IN HEART FAILURE　p. 261-266　2002　Research paper (international conference proceedings)

The role of neuropilin in vascular and tumor biology

M Klagsbrun, S Takashima, R Mamluk

NEUROPILIN: FROM NERVOUS SYSTEM TO VASCULAR AND TUMOR BIOLOGY　Vol. 515　p. 33-+　2002　Research paper (scientific journal)

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

M Asakura, M Kitakaze, S Takashima, Y Liao, F Ishikura, T Yoshinaka, H Ohmoto, K Node, K Yoshino, H Ishiguro, H Asanuma, S Sanada, Y Matsumura, H Takeda, S Beppu, M Tada, M Hori, S Higashiyama

NATURE MEDICINE　Vol. 8　No. 1　p. 35-40　2002/01　Research paper (scientific journal)

Adenosine-induced cardiac gene expression of ischemic murine hearts revealed by cDNA array hybridization

M Asakura, M Kitakaze, Y Sakata, H Asanuma, S Sanada, J Kim, H Ogida, YL Liao, K Node, S Takashima, M Tada, M Hori

CIRCULATION JOURNAL　Vol. 66　No. 1　p. 93-96　2002/01　Research paper (scientific journal)

VEGF(165) mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF(165)-receptor binding

S Soker, HQ Miao, M Nomi, S Takashima, M Klagsbrun

JOURNAL OF CELLULAR BIOCHEMISTRY　Vol. 85　No. 2　p. 357-368　2002　Research paper (scientific journal)

[Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart].

Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Asakura M, Kitakaze M, Hori M

Journal of cardiology　Vol. 39　No. 1　p. 55-56　2002/01

Nifedipine limits infarct size via NO-dependent mechanisms in dogs

H Asanuma, M Kitakaze, H Funaya, S Takashima, T Minamino, K Node, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, T Kuzuya, M Tada, M Hori

BASIC RESEARCH IN CARDIOLOGY　Vol. 96　No. 5　p. 497-505　2001/09　Research paper (scientific journal)

Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium

M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Shinozaki, H Mori, H Sato, T Kuzuya, M Hori

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 33　No. 9　p. 1727-1737　2001/09　Research paper (scientific journal)

Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-Dependent mechanisms in canine hearts

H Asanuma, M Kitakaze, K Node, S Takashima, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, M Tada, T Kuzuya, M Hori

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 15　No. 3　p. 225-231　2001/05　Research paper (scientific journal)

cDNA array hybridization reveals cardiac gene expression in acute ischemic murine hearts.

Kitakaze M, Asakura M, Sakata Y, Asanuma H, Sanada S, Kuzuya T, Miyazaki J, Takashima S, Hori M

Cardiovasc Drugs Ther　Vol. 15: 125-130　2001/03　Research paper (scientific journal)

Follow-up on heart transplant after left ventricular assist system bridge

Norihide Fukushima, Shigeaki Ohtake, Yoshiki Sawa, Motonobu Nishimura, Goro Matsumiya, Seiji Takashima, Masatsugu Hori, Ryota Shirakura, Hikaru Matsuda

Asian Cardiovascular and Thoracic Annals　Vol. 9　No. 4　p. 312-314　2001　Research paper (scientific journal)

Role of mitochondrial and sarcolemmal KATP channels in ischemic preconditioning of the canine heart.

Sanada S, Kitakaze M, Asanuma H, Harada K, Ogita H, Node K, Takashima S, Sakata Y, Asakura M, Shinozaki Y, Mori H, Kuzuya T, Hori M

Am J Physiol Heart Circ Physiol　Vol. 280　p. H256-H263-H263　2001　Research paper (scientific journal)

Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart.

Sanada S, Kitakaze M, Papst PJ, Hatanaka K, Asanuma H, Aki T, Shinozaki Y, Ogita H, Node K, Takashima S, Asakura M, Yamada J, Fukushima T, Ogai A, Kuzuya T, Mori H, Terada N, Yoshida K, Hori M

Circ Res　Vol. 88　p. 175-180　2001　Research paper (scientific journal)

Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: The role of protein kinase a and p38 mitogen-activated protein kinase.

Sanada S, Kitakaze M, Papst PJ, Asanuma H, Node K, Takashima S, Asakura M, Ogita H, Liao Y, Sakata Y, Ogai A, Fukushima T, Yamada J, Shinozaki Y, Kuzuya T, Mori H, Terada N, Hori M

Circulation　Vol. 104　p. 705-710　2001　Research paper (scientific journal)

Differential subcellular actions of ACE inhibitors and AT1 receptor antagonists on cardiac remodeling induced by chronic inhibition of no synthesis in rats.

Sanada S, Kitakaze M, Node K, Takashima S, Ogai A, Asanuma H, Sakata Y, Asakura M, Ogita H, Liao Y, Fukushima T, Yamada J, Minamino T, Kuzuya T, Hori M

Hypertension　Vol. 38　p. 404-411　2001　Research paper (scientific journal)

Management of candidates for heart transplantation in Japan.

Fukushima N, Ohtake S, Sawa Y, Nishimura M, Matsumiya G, Nakata S, Yamamoto K, Takashima S, Hori M, Shirakura R, Matsuda H

Transplantation proceedings　Vol. 32　No. 7　p. 1529-1531　2000/11

Cellular mechanisms of cardioprotection afforded by inhibitors of angiotensin converting enzyme in ischemic hearts: Role of bradykinin and nitric oxide

M Kitakaze, K Node, S Takashima, T Minamino, T Kuzuya, M Hori

HYPERTENSION RESEARCH　Vol. 23　No. 3　p. 253-259　2000/05　Research paper (scientific journal)

Successful launch of cardiac transplantation in Japan

Masatsugu Hori, Kazuhiro Yamamoto, Kazuhisa Kodama, Seiji Takashima, Hiroshi Sato, Yukihiro Koretsune, Tsunehiko Kuzuya, Chikao Yutani, Norihide Fukushima, Shigeaki Ohtake, Ryota Shirakura, Hikaru Matsuda

Japanese Circulation Journal　Vol. 64　No. 5　p. 326-332　2000/05　Research paper (scientific journal)

Synergic role of opening of the sarcolemmal and mitochondrial ATP-sensitive K^+ channels in ischemic preconditioning.

KITAKAZE Masafumi, SANADA Shoji, ASANUMA Hiroshi, NODE Koichi, MINAMINO Tetsuo, TAKASHIMA Seiji, CHUJO Mitsuaki, SHINOZAKI Yoshiro, MORI Hidezo, KUZUYA Tsunehiko, HORI Masatsugu

Japanese Journal of Electrocardiology　Vol. 20　No. 2　p. 103-111　2000/03/25

Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity

ML Gagnon, DR Bielenberg, Z Gechtman, HQ Miao, S Takashima, S Soker, M Klagsbrun

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 97　No. 6　p. 2573-2578　2000/03　Research paper (scientific journal)

Role of adenosine in cardioprotection

M Kitakaze, T Minamino, K Node, S Takashima, H Funaya, T Kuzuya, M Hori

HEART FAILURE　p. 183-195　2000　Research paper (international conference proceedings)

Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5 '-nucleotidase activity and adenosine release in canine hearts

M Kitakaze, S Takashima, T Minamino, K Node, Y Shinozaki, H Mori, T Kuzuya, M Hori

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION　Vol. 63　No. 7　p. 542-553　1999/07　Research paper (scientific journal)

Purification and characterization of a novel vascular endothelial cell growth inhibitor secreted by macrophage-like U-937 cells

Norihiko Nakano, Shigeki Higashiyama, Seiji Takashima, Nobuo Tsuruoka, Michael Klagsbrun, Naoyuki Taniguchi

Journal of Biochemistry　Vol. 125　No. 2　p. 368-374　1999　Research paper (scientific journal)

Adenosine and Cardioprotection in the Diseased Heart

Masafumi Kitakaze, Tetsuo Minamino, Koichi Node, Seiji Takashima, Hiroharu Funaya, Tsunehiko Kuzuya, Masatsugu Hori

Circulation Journal　Vol. 63　No. 4　p. 231-243　1999　Research paper (scientific journal)

Temporary acidosis during reperfusion limits myocardial infarct size in dogs

M Kitakaze, S Takashima, H Funaya, T Minamino, K Node, Y Shinozaki, H Mori, M Hori

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 272　No. 5　p. H2071-H2078　1997/05　Research paper (scientific journal)

Inhibition of endothelial cell growth by macrophage-like U-937 cell-derived oncostatin M, leukemia inhibitory factor, and transforming growth factor beta 1

S Takashima, M Klagsbrun

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 271　No. 40　p. 24901-24906　1996/10　Research paper (scientific journal)

Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.

Kuroki, M, Voest, E. E, Amano, S, Beerepoot, L. V, Takashima, S, Tolentino, M, Kim, R. Y, Rohan, R. M, Colby, K. A, Yeo, K. T, Adamis, A

J Clin Invest　Vol. 98　p. 1667-1675　1996/05　Research paper (scientific journal)

DOWNWARD SHIFT OF CORONARY PRESSURE-FLOW RELATIONSHIP FOLLOWING A BRIEF PERIOD OF ISCHEMIA IN DOGS

T MORIOKA, M KITAKAZE, T MINAMINO, S TAKASHIMA, K NODE, Y OKAZAKI, H SATO, Y SHINOZAKI, M CHUJO, H MORI, K MIYAZAKI, M INOUE, M HORI, T KAMADA

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 269　No. 4　p. H1237-H1245　1995/10　Research paper (scientific journal)

α1-Adrenoceptor activation increases ecto-5'-nucleotidase activity and adenosine release in rat cardiomyocytes by activating protein kinase C

M. Kitakaze, M. Hori, T. Morioka, T. Minamino, S. Takashima, Y. Okazaki, K. Node, K. Komamura, K. Iwakura, T. Itoh, M. Inoue, T. Kamada

Circulation　Vol. 91　No. 8　p. 2226-2234　1995　Research paper (scientific journal)

AICA RIBOSIDE IMPROVES MYOCARDIAL-ISCHEMIA IN CORONARY MICROEMBOLIZATION IN DOGS

M HORI, M KITAKAZE, S TAKASHIMA, T MORIOKA, H SATO, T MINAMINO, K NODE, K KOMAMURA, M INOUE, T KAMADA

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 267　No. 4　p. H1483-H1495　1994/10　Research paper (scientific journal)

AICA riboside improves myocardial ischemia in coronary microembolization in dogs.

Hori M, Kitakaze M, Takashima S, Morioka T, Sato H, Minamino T, Node K, Komamura K, Inoue M, Kamada T

Am J Physiol　Vol. 267　No. 1 Pt 2　p. H1483-H1495　1994/10　Research paper (scientific journal)

SUPEROXIDE-DISMUTASE RESTORES CONTRACTILE AND METABOLIC DYSFUNCTION THROUGH AUGMENTATION OF ADENOSINE RELEASE IN CORONARY MICROEMBOLIZATION

S TAKASHIMA, M HORI, M KITAKAZE, H SATO, M INOUE, T KAMADA

CIRCULATION　Vol. 87　No. 3　p. 982-995　1993/03　Research paper (scientific journal)

Activation of K+ channels enhances adenosine-induced coronary vasodilation in dogs

M. Kitakaze, T. Morioka, S. Takashima, T. Minamino, H. Sato, M. Inoue, M. Hori, T. Kamada

Therapeutic Research　Vol. 14　No. 3　p. 786-794　1993　Research paper (international conference proceedings)

Cardiac hypertrophy inhibitory effects in cardiomyopathy spontaneity hamster of Na+/H+ exchange inhibitors.

Jpn. J. Clin. Pharmacol. Ther.　Vol. 24　No. 1　p. 17-18　1993

An increase in adenosine release contributes to the infarct size limiting effect of ischemic preconditioning

Masatsugu Hori, Masafumi Kitakaze, Toshikazu Morioka, Tetsuo Minamino, Seiji Takashima, Hiroshi Sato, Koichi Node, Yoshiro Shinozaki, Mitsuaki Chujo, Hidezo Mori, Michitoshi Inoue, Takenobu Kamada

JAPANESE CIRCULATION JOURNAL　Vol. 57　p. 1330-1332　1993　Research paper (scientific journal)

Reperfusion after brief ischemia disrupts the microtubule network in canine hearts

H. Sato, M. Hori, M. Kitakaze, K. Iwai, S. Takashima, H. Kurihara, M. Inoue, T. Kamada

Circulation Research　Vol. 72　No. 2　p. 361-375　1993　Research paper (scientific journal)

SUPEROXIDE-DISMUTASE ENHANCES ISCHEMIA-INDUCED REACTIVE HYPEREMIC FLOW AND ADENOSINE RELEASE IN DOGS - A ROLE OF 5'-NUCLEOTIDASE ACTIVITY

M KITAKAZE, M HORI, S TAKASHIMA, K IWAI, H SATO, M INOUE, A KITABATAKE, T KAMADA

CIRCULATION RESEARCH　Vol. 71　No. 3　p. 558-566　1992/09　Research paper (scientific journal)

Disruption of Microtubules in Cultured Neonatal Rat Cardiomyocytes During Rapid Contractions: Protective effects of beta-adrenoceptor antagonist

Masatsugu Hori, Hiroshi Sato, Kunimitsu Iwai, Seiji Takashima, Hideyuki Sato, Akira Kitabatake, Takenobu Kamada, Michitoshi Inoue, Masatsugu Hori

Japanese Circulation Journal　Vol. 56　No. 1　p. 62-68　1992　Research paper (scientific journal)

Endogenous adenosine inhibits platelet aggregation during myocardial ischemia in dogs

M. Kitakaze, M. Hori, H. Sato, S. Takashima, M. Inoue, A. Kitabatake, T. Kamada

Circulation Research　Vol. 69　No. 5　p. 1402-1408　1991　Research paper (scientific journal)