FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis.

Kenta Niimi, Misaki Kohara, Eriko Sedoh, Moe Fukumoto, Satoshi Shibata, Toshinori Sawano, Fumi Tashiro, Satsuki Miyazaki, Yoshiaki Kubota, Jun-Ichi Miyazaki, Shinobu Inagaki, Tatsuo Furuyama

Development (Cambridge, England)　Vol. 147　No. 2　2020/01/17　Research paper (scientific journal)

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.

Cheng HW, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, Scandella E, Robinson MD, Miyazaki J, Tersteegen A, Sorg U, Pfeffer K, Rülicke T, Hehlgans T, Ludewig B

Nat Commun　Vol. 10　No. 1　2019/04　Research paper (scientific journal)

Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion

Yuichiro Munakata, Tetsuya Yamada, Junta Imai, Kei Takahashi, Sohei Tsukita, Yuta Shirai, Shinjiro Kodama, Yoichiro Asai, Takashi Sugisawa, Yumiko Chiba, Keizo Kaneko, Kenji Uno, Shojiro Sawada, Hiroyasu Hatakeyama, Makoto Kanzaki, Jun-Ichi Miyazaki, Yoshitomo Oka, Hideki Katagiri

Scientific Reports　Vol. 8　No. 1　2018/12/01　Research paper (scientific journal)

Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas

Moe Fukumoto, Kanako Kondo, Kazumasa Uni, Tomoko Ishiguro, Mikiko Hayashi, Shinnosuke Ueda, Itsuki Mori, Kenta Niimi, Fumi Tashiro, Satsuki Miyazaki, Jun-Ichi Miyazaki, Shinobu Inagaki, Tatsuo Furuyama

Angiogenesis　Vol. 21　No. 2　p. 203-214　2018/05/01　Research paper (scientific journal)

Mouse GTSF1 is an essential factor for secondary piRNA biogenesis.

Takuji Yoshimura, Toshiaki Watanabe, Satomi Kuramochi-Miyagawa, Noriaki Takemoto, Yusuke Shiromoto, Akihiko Kudo, Masami Kanai-Azuma, Fumi Tashiro, Satsuki Miyazaki, Ami Katanaya, Shinichiro Chuma, Jun-Ichi Miyazaki

EMBO reports　Vol. 19　No. 4　2018/04　Research paper (scientific journal)

IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells

Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno

Journal of Cell Biology　Vol. 217　No. 4　p. 1287-1301　2018/04/01　Research paper (scientific journal)

Non-surgical model for alveolar bone regeneration by bone morphogenetic protein-2/7 gene therapy

Mariko Kawai, Yo-Hei Kataoka, Junya Sonobe, Hiromitsu Yamamoto, Masakazu Inubushi, Takuya Ishimoto, Takayoshi Nakano, Hiroki Maruyama, Jun-Ichi Miyazaki, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura

Journal of Periodontology　Vol. 89　No. 1　p. 85-92　2018/01/01　Research paper (scientific journal)

マウスGTSF1はPIWI-piRNAがターゲットRNAを切断するために重要な因子である

能村 卓慈, 渡部 聡朗, 宮川 さとみ, 竹本 記章, 城本 悠助, 宮東 昭彦, 金井 正美, 田代 文, 宮崎 早月, 刀谷 在美, 中馬 新一郎, 宮崎 純一

生命科学系学会合同年次大会　Vol. 2017年度　p. [1P-0795]　2017/12

Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin

Takumi Matsuura, Satsuki Miyazaki, Tatsushi Miyazaki, Fumi Tashiro, Jun-ichi Miyazaki

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/09　Research paper (scientific journal)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Shunsuke Kon, Kojiro Ishibashi, Hiroto Katoh, Sho Kitamoto, Takanobu Shirai, Shinya Tanaka, Mihoko Kajita, Susumu Ishikawa, Hajime Yamauchi, Yuta Yako, Tomoko Kamasaki, Tomohiro Matsumoto, Hirotaka Watanabe, Riku Egami, Ayana Sasaki, Atsuko Nishikawa, Ikumi Kameda, Takeshi Maruyama, Rika Narumi, Tomoko Morita, Yoshiteru Sasaki, Ryosuke Enoki, Sato Honma, Hiromi Imamura, Masanobu Oshima, Tomoyoshi Soga, Jun-ichi Miyazaki, Michael R. Duchen, Jin-Min Nam, Yasuhito Onodera, Shingo Yoshioka, Junichi Kikuta, Masaru Ishii, Masamichi Imajo, Eisuke Nishida, Yoichiro Fujioka, Yusuke Ohba, Toshiro Sato, Yasuyuki Fujita

NATURE CELL BIOLOGY　Vol. 19　No. 5　p. 530-+　2017/05　Research paper (scientific journal)

Transgenic Expression of a Single Transcription Factor Pdx1 Induces Transdifferentiation of Pancreatic Acinar Cells to Endocrine Cells in Adult Mice

Satsuki Miyazaki, Fumi Tashiro, Jun-ichi Miyazaki

PLOS ONE　Vol. 11　No. 8　2016/08　Research paper (scientific journal)

Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis

Noriaki Takemoto, Takuji Yoshimura, Satsuki Miyazaki, Fumi Tashiro, Jun-ichi Miyazaki

PLOS ONE　Vol. 11　No. 3　2016/03　Research paper (scientific journal)

Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic beta Cell Line

Masaki Kobayashi, Eiji Yamato, Koji Tanabe, Fumi Tashiro, Satsuki Miyazaki, Jun-ichi Miyazaki

PLOS ONE　Vol. 11　No. 3　2016/03　Research paper (scientific journal)

B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow

Takaaki Hanafusa, Kenichi Kato, Hiroaki Azukizawa, Jun-ichi Miyazaki, Junji Takeda, Ichiro Katayama

JOURNAL OF DERMATOLOGICAL SCIENCE　Vol. 81　No. 3　p. 173-181　2016/03　Research paper (scientific journal)

マウスの始原生殖細胞においてGTSF1は二次piRNAの加工に必須である(Mouse GTSF1 is essential for secondary piRNA processing in goncytes)

能村 卓慈, 竹本 記章, 宮川 さとみ, 渡部 聡朗, 城本 悠助, 宮東 昭彦, 金井 正美, 田代 文, 宮崎 早月, 刀谷 在美, 中馬 新一郎, 仲野 徹, 宮崎 純一

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [2P0796]-[2P0796]　2015/12

Potent Insulin Secretagogue from Scoparia dulcis Linn of Nepalese Origin

Khaga Raj Sharma, Achyut Adhikari, Rahman M. Hafizur, Abdul Hameed, Sayed Ali Raza, Surya Kant Kalauni, Jun-Ichi Miyazaki, M. Iqbal Choudhary

PHYTOTHERAPY RESEARCH　Vol. 29　No. 10　p. 1672-1675　2015/10　Research paper (scientific journal)

A novel insulinotropic mechanism of whole grain-derived -oryzanol via the suppression of local dopamine D-2 receptor signalling in mouse islet

Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Yuzuru Ohshiro, Hideaki Tanaka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Shogo Ishiuchi, Masanori Nakata, Toshihiko Yada, Jun-ichi Miyazaki, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzaki

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 18　p. 4519-4534　2015/09　Research paper (scientific journal)

Dietary supplementation with sodium nitrite can exert neuroprotective effects on global cerebral ischemia/reperfusion in mice

Takasuke Fukuda, Manabu Kakinohana, Chitoshi Takayama, Masayuki Matsushita, Kazuhiro Sugahara

Journal of Anesthesia　Vol. 29　No. 4　p. 609-617　2015/08/22　Research paper (scientific journal)

gamma-Oryzanol Protects Pancreatic beta-Cells Against Endoplasmic Reticulum Stress in Male Mice

Chisayo Kozuka, Sumito Sunagawa, Rei Ueda, Moritake Higa, Hideaki Tanaka, Chigusa Shimizu-Okabe, Shogo Ishiuchi, Chitoshi Takayama, Masayuki Matsushita, Masato Tsutsui, Jun-ichi Miyazaki, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzaki

ENDOCRINOLOGY　Vol. 156　No. 4　p. 1242-1250　2015/04　Research paper (scientific journal)

Preserving Mafa Expression in Diabetic Islet beta-Cells Improves Glycemic Control in Vivo

Taka-aki Matsuoka, Hideaki Kaneto, Satoshi Kawashima, Takeshi Miyatsuka, Yoshihiro Tochino, Atsushi Yoshikawa, Akihisa Imagawa, Jun-ichi Miyazaki, Maureen Gannon, Roland Stein, Iichiro Shimomura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 12　p. 7647-7657　2015/03　Research paper (scientific journal)

TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses

Tomohisa Okamura, Shuji Sumitomo, Kaoru Morita, Yukiko Iwasaki, Mariko Inoue, Shinichiro Nakachi, Toshihiko Komai, Hirofumi Shoda, Jun-ichi Miyazaki, Keishi Fujio, Kazuhiko Yamamoto

NATURE COMMUNICATIONS　Vol. 6　2015/02　Research paper (scientific journal)

Somatostatin Analog Inhibits the Growth of Insulinoma Cells by p27-Mediated G1 Cell Cycle Arrest

Takeshi Aoki, Fuyuhiko Motoi, Naoaki Sakata, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Jun-ichi Miyazaki, Michiaki Unno

PANCREAS　Vol. 43　No. 5　p. 720-729　2014/07　Research paper (scientific journal)

Auto-Regulation of the Sohlh1 Gene by the SOHLH2/SOHLH1/SP1 Complex: Implications for Early Spermatogenesis and Oogenesis

Shuichi Toyoda, Takuji Yoshimura, Junya Mizuta, Jun-ichi Miyazaki

PLOS ONE　Vol. 9　No. 7　2014/07　Research paper (scientific journal)

Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus

Yuichiro Hayashi, Yoko Nabeshima, Katsunori Kobayashi, Tsuyoshi Miyakawa, Koichi Tanda, Keizo Takao, Hidenori Suzuki, Eisaku Esumi, Shigeru Noguchi, Yukiko Matsuda, Toshikuni Sasaoka, Tetsuo Noda, Jun-ichi Miyazaki, Masayoshi Mishina, Kazuo Funabiki, Yo-ichi Nabeshima

MOLECULAR BRAIN　Vol. 7　2014/06　Research paper (scientific journal)

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

Jonghyeob Lee, Takuya Sugiyama, Yinghua Liu, Jing Wang, Xueying Gu, Ji Lei, James F. Markmann, Satsuki Miyazaki, Jun-ichi Miyazaki, Gregory L. Szot, Rita Bottino, Seung K. Kim

ELIFE　Vol. 2　2013/11　Research paper (scientific journal)

Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells

Juliane Klose, Nils Ole Schmidt, Arthur Melms, Makoto Dohi, Jun-ichi Miyazaki, Felix Bischof, Bernhard Greve

JOURNAL OF NEUROINFLAMMATION　Vol. 10　2013/09　Research paper (scientific journal)

Functional Analysis of Tcl1 Using Tcl1-Deficient Mouse Embryonic Stem Cells

Tatsushi Miyazaki, Satsuki Miyazaki, Masafumi Ashida, Tomofumi Tanaka, Fumi Tashiro, Jun-ichi Miyazaki

PLoS ONE　Vol. 8　No. 8　2013/08/05　Research paper (scientific journal)

Microarray Analysis of Novel Candidate Genes Responsible for Glucose-Stimulated Insulin Secretion in Mouse Pancreatic beta Cell Line MIN6

Eiji Yamato, Fumi Tashiro, Jun-ichi Miyazaki

PLOS ONE　Vol. 8　No. 4　2013/04　Research paper (scientific journal)

Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis

Ryosuke Fujiki, Akinobu Sato, Katsuhiko Hata, Fumi Tashiro, Noriko Yasuhara, Jun-ichi Miyazaki, Yoshihiro Yoneda, Masashi Fujitani, Toshihide Yamashita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 430　No. 2　p. 604-609　2013/01　Research paper (scientific journal)

Acinar-to-Ductal Metaplasia Induced by Adenovirus-Mediated Pancreatic Expression of Isl1

Satsuki Miyazaki, Fumi Tashiro, Junji Fujikura, Eiji Yamato, Jun-ichi Miyazaki

PLOS ONE　Vol. 7　No. 10　2012/10　Research paper (scientific journal)

Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic beta cells

Satsuki Miyazaki, Rie Minamida, Tatsuo Furuyama, Fumi Tashiro, Eiji Yamato, Shinobu Inagaki, Jun-ichi Miyazaki

GENES TO CELLS　Vol. 17　No. 9　p. 758-767　2012/09　Research paper (scientific journal)

Analysis of the transcription factor cascade that induces endocrine and exocrine cell lineages from pancreatic progenitor cells using a polyoma-based episomal vector system

Eiji Yamato, Yohei Bamba, Yukimasa Kamiya, Kiyohito Yagi, Jun-ichi Miyazaki

JOURNAL OF DIABETES INVESTIGATION　Vol. 3　No. 1　p. 41-51　2012/02　Research paper (scientific journal)

BMP-2 gene transfer under various conditions with in vivo electroporation and bone induction

H. Yamamoto, M. Kawai, N. Shiotsu, M. Watanabe, Y. Yoshida, K. Suzuki, H. Maruyama, J.-I. Miyazaki, M. Ikegame, K. Bessho, T. Yamamoto

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　Vol. 24　No. 1　p. 49-53　2012

High Expression of IL-22 Suppresses Antigen-Induced Immune Responses and Eosinophilic Airway Inflammation via an IL-10-Associated Mechanism

Kazuyuki Nakagome, Mitsuru Imamura, Kimito Kawahata, Hiroaki Harada, Katsuhide Okunishi, Taku Matsumoto, Oh Sasaki, Ryoichi Tanaka, Mitsunobu R. Kano, He Chang, Haruo Hanawa, Jun-ichi Miyazaki, Kazuhiko Yamamoto, Makoto Dohi

JOURNAL OF IMMUNOLOGY　Vol. 187　No. 10　p. 5077-5089　2011/11　Research paper (scientific journal)

Advanced Glycation End Products Are Direct Modulators of beta-Cell Function

Melinda T. Coughlan, Felicia Y. T. Yap, David C. K. Tong, Sofianos Andrikopoulos, Anna Gasser, Vicki Thallas-Bonke, Diane E. Webster, Jun-ichi Miyazaki, Thomas W. Kay, Robyn M. Slattery, David M. Kaye, Brian G. Drew, Bronwyn A. Kingwell, Spiros Fourlanos, Per-Henrik Groop, Leonard C. Harrison, Mikael Knip, Josephine M. Forbes

DIABETES　Vol. 60　No. 10　p. 2523-2532　2011/10　Research paper (scientific journal)

Establishment of a new murine model of hypercalcemia with anorexia by overexpression of soluble receptor activator of NF-κB ligand using an adenovirus vector

Tetsuro Enomoto, Yuriko Furuya, Yoshiya Tomimori, Kaoru Mori, Jun-Ichi Miyazaki, Hisataka Yasuda

Journal of Bone and Mineral Metabolism　Vol. 29　No. 4　p. 414-421　2011/07　Research paper (scientific journal)

Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 beta-cell line

Kazuya Yamagata, Takafumi Senokuchi, Meihong Lu, Makoto Takemoto, Md. Fazlul Karim, Chisa Go, Yoshifumi Sato, Mitsutoki Hatta, Tatsuya Yoshizawa, Eiichi Araki, Junichi Miyazaki, Wen-Jie Song

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 407　No. 3　p. 620-625　2011/04　Research paper (scientific journal)

PDGFR alpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia

Katsuto Tamai, Takehiko Yamazaki, Takenao Chino, Masaru Ishii, Satoru Otsuru, Yasushi Kikuchi, Shin Iinuma, Kotaro Saga, Keisuke Nimura, Takashi Shimbo, Noriko Umegaki, Ichiro Katayama, Jun-ichi Miyazaki, Junji Takeda, John A. McGrath, Jouni Uitto, Yasufumi Kaneda

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 108　No. 16　p. 6609-6614　2011/04　Research paper (scientific journal)

Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons

Kenta Kobayashi, Tomoyuki Masuda, Masanori Takahashi, Jun-ichi Miyazaki, Masahiro Nakagawa, Motokazu Uchigashima, Masahiko Watanabe, Hiroyuki Yaginuma, Noriko Osumi, Kozo Kaibuchi, Kazuto Kobayashi

EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 33　No. 4　p. 612-621　2011/02　Research paper (scientific journal)

Embryonic stem cells maintain an undifferentiated state on dendrimer-immobilized surface with D-glucose display

Shohreh Mashayekhan, Mee Hae Kim, Masahiro Kino-Oka, Jun Ichi Miyazaki, Masahito Taya

Polymers　Vol. 3　No. 4　p. 2078-2087　2011　Research paper (scientific journal)

Cellular Injury of Cardiomyocytes during Hepatocyte Growth Factor Gene Transfection with Ultrasound-Triggered Bubble Liposome Destruction.

Komamura K, Tatsumi R, Tsujita-Kuroda Y, Onoe T, Matsumoto K, Nakamura T, Miyazaki J, Horio T, Sugimachi M

Journal of drug delivery　Vol. 2011　p. 453619-453619　2011　Research paper (scientific journal)

Proatherogenic Effect of Interleukin-18 is Exerted with High-fat Diet, but not with Normal Diet in Spontaneously Hyperlipidemic Mice

Takatoshi Imai, Yoichi Oikawa, Akira Shimada, Sumito Oguchi, Yoshihiro Takamiya, Takeshi Katsuki, Yoshiaki Okubo, Tadashi Osaki, Hideaki Tahara, Yoshibumi Matsushima, Jun-ichi Miyazaki, Hiroshi Itoh

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　Vol. 18　No. 12　p. 1090-1101　2011　Research paper (scientific journal)

CXCR4 Is Required for Proper Regional and Laminar Distribution of Cortical Somatostatin-, Calretinin-, and Neuropeptide Y-Expressing GABAergic Interneurons

Daisuke H. Tanaka, Sakae Mikami, Takashi Nagasawa, Jun-ichi Miyazaki, Kazunori Nakajima, Fujio Murakami

CEREBRAL CORTEX　Vol. 20　No. 12　p. 2810-2817　2010/12　Research paper (scientific journal)

Nuclear Hormone Retinoid X Receptor (RXR) Negatively Regulates the Glucose-Stimulated Insulin Secretion of Pancreatic beta-Cells

Satsuki Miyazaki, Hidenori Taniguchi, Yusuke Moritoh, Funti Tashiro, Tsunehiko Yamamoto, Eiji Yamato, Hiroshi Ikegami, Keiko Ozato, Jun-ichi Miyazaki

DIABETES　Vol. 59　No. 11　p. 2854-2861　2010/11　Research paper (scientific journal)

CXC chemokine ligand 10 DNA vaccination plus complete Freund's adjuvant reverses hyperglycemia in non-obese diabetic mice

Yoichi Oikawa, Akira Shimada, Yoshifumi Yamada, Yoshiaki Okubo, Takeshi Katsuki, Toshikatsu Shigihara, Jun-Ichi Miyazaki, Shosaku Narumi, Hiroshi Itoh

Review of Diabetic Studies　Vol. 7　No. 3　p. 198-213　2010/09　Research paper (scientific journal)

Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition

Fumi Tashiro, Masami Kanai-Azuma, Satsuki Miyazaki, Masahiro Kato, Tomofumi Tanaka, Shuichi Toyoda, Eiji Yamato, Hayato Kawakami, Tatsushi Miyazaki, Jun-Ichi Miyazaki

GENES TO CELLS　Vol. 15　No. 8　p. 813-828　2010/08　Research paper (scientific journal)

Establishment of new clonal pancreatic beta-cell lines (MIN6-K) useful for study of incretin/cyclic adenosine monophosphate signaling

Masahiro Iwasaki, Kohtaro Minami, Tadao Shibasaki, Takashi Miki, Jun-ichi Miyazaki, Susumu Seino

JOURNAL OF DIABETES INVESTIGATION　Vol. 1　No. 4　p. 137-142　2010/08　Research paper (scientific journal)

Rim2 alpha Determines Docking and Priming States in Insulin Granule Exocytosis

Takao Yasuda, Tadao Shibasaki, Kohtaro Minami, Harumi Takahashi, Akira Mizoguchi, Yoshitsugu Uriu, Tomohiro Numata, Yasuo Mori, Jun-ichi Miyazaki, Takashi Miki, Susumu Seino

CELL METABOLISM　Vol. 12　No. 2　p. 117-129　2010/08　Research paper (scientific journal)

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Hiroyuki Kitajima, Jun-ichi Miyazaki, Hiroshi Kawamoto, Yasuhiro Mouri, Mitsuru Matsumoto

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 207　No. 5　p. 963-971　2010/05　Research paper (scientific journal)

インスリン顆粒の開口放出機構におけるRim2αの役割

安田 貴雄, 柴崎 忠雄, 三木 隆司, 高橋 晴美, 宮崎 純一, 南 幸太郎, 清野 進

糖尿病　Vol. 53　No. Suppl.1　p. S-93　2010/04

Dendrimer-Immobilized Culture Surface as a Tool to Promote Aggregate Formation of Anchorage-Dependent Cells

Mee-Hae Kim, Masahiro Kino-oka, Jun-ichi Miyazaki, Masahito Taya

ANIMAL CELL TECHNOLOGY: BASICS & APPLIED ASPECTS　Vol. 16　p. 57-63　2010　Research paper (international conference proceedings)

Participation of CD11b and F4/80 Molecules in the Conjunctival Eosinophilia of Experimental Allergic Conjunctivitis

Atsuki Fukushima, Waka Ishida, Ayako Ojima, Mina Kajisako, Tamaki Sumi, Jun Yamada, Emi Tsuru, Jun-ichi Miyazaki, Akira Tominaga, Hideo Yagita

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY　Vol. 151　No. 2　p. 129-136　2010　Research paper (scientific journal)

The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice

Kenzi Saito, Toshikazu Kakizaki, Ryotaro Hayashi, Hiroshi Nishimaru, Tomonori Furukawa, Yoichi Nakazato, Shigeo Takamori, Satoe Ebihara, Masakazu Uematsu, Masayoshi Mishina, Jun-ichi Miyazaki, Minesuke Yokoyama, Shiro Konishi, Koichi Inoue, Atsuo Fukuda, Manabu Fukumoto, Kenji Nakamura, Kunihiko Obata, Yuchio Yanagawa

MOLECULAR BRAIN　Vol. 3　2010　Research paper (scientific journal)

Systemic overexpression of IFN-gamma and IL-5 exacerbates early phase reaction and conjunctival eosinophilia, respectively, in experimental allergic conjunctivitis

W. Ishida, E. Tsuru, A. Tominaga, J-i Miyazaki, T. Higuchi, S. Sakamoto, A. Fukushima

BRITISH JOURNAL OF OPHTHALMOLOGY　Vol. 93　No. 12　p. 1680-1685　2009/12　Research paper (scientific journal)

Simple strategy for bone regeneration with a BMP-2/7 gene expression cassette vector

Mariko Kawai, Hiroki Maruyama, Kazuhisa Bessho, Hiromitsu Yamamoto, Jun-Ichi Miyazaki, Toshio Yamamoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 390　No. 3　p. 1012-1017　2009/12　Research paper (scientific journal)

Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes

Takuji Yoshimura, Shuichi Toyoda, Satomi Kuramochi-Miyagawa, Tatsushi Miyazaki, Satsuki Miyazaki, Fumi Tashiro, Eiji Yamato, Toru Nakano, Jun-ichi Miyazaki

DEVELOPMENTAL BIOLOGY　Vol. 335　No. 1　p. 216-227　2009/11　Research paper (scientific journal)

Sema4D Deficiency Results in an Increase in the Number of Oligodendrocytes in Healthy and Injured Mouse Brains

Yoshitaka Taniguchi, Mayumi Amazaki, Tatsuo Furuyama, Wataru Yamaguchi, Mizue Takahara, Orie Saino, Takeshi Wada, Hitoshi Niwa, Fumi Tashiro, Jun-ichi Miyazaki, Mikihiko Kogo, Tomohiro Matsuyama, Shinobu Inagaki

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 87　No. 13　p. 2833-2841　2009/10　Research paper (scientific journal)

IFN-gamma Attenuates Antigen-Induced Overall Immune Response in the Airway As a Th1-Type Immune Regulatory Cytokine

Kazuyuki Nakagome, Katsuhide Okunishi, Mitsuru Imamura, Hiroaki Harada, Taku Matsumoto, Ryoichi Tanaka, Jun-ichi Miyazaki, Kazuhiko Yamamoto, Makoto Dohi

JOURNAL OF IMMUNOLOGY　Vol. 183　No. 1　p. 209-220　2009/07　Research paper (scientific journal)

Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes

Yasuhiko Kanazawa, Akira Shimada, Yoichi Oikawa, Yoshiaki Okubo, Ai Tada, Takatoshi Imai, Junichi Miyazaki, Hiroshi Itoh

JOURNAL OF AUTOIMMUNITY　Vol. 32　No. 2　p. 104-109　2009/03　Research paper (scientific journal)

Stepwise Development of Hematopoietic Stem Cells from Embryonic Stem Cells

Kenji Matsumoto, Takayuki Isagawa, Toshinobu Nishimura, Takunori Ogaeri, Koji Eto, Satsuki Miyazaki, Jun-ichi Miyazaki, Hiroyuki Aburatani, Hiromitsu Nakauchi, Hideo Ema

PLOS ONE　Vol. 4　No. 3　2009/03　Research paper (scientific journal)

Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy

Motoi Kanagawa, Akemi Nishimoto, Tomohiro Chiyonobu, Satoshi Takeda, Yuko Miyagoe-Suzuki, Fan Wang, Nobuhiro Fujikake, Mariko Taniguchi, Zhongpeng Lu, Masaji Tachikawa, Yoshitaka Nagai, Fumi Tashiro, Jun-Ichi Miyazaki, Youichi Tajima, Shin'ichi Takeda, Tamao Endo, Kazuhiro Kobayashi, Kevin P. Campbell, Tatsushi Toda

HUMAN MOLECULAR GENETICS　Vol. 18　No. 4　p. 621-631　2009/02　Research paper (scientific journal)

Random Walk Behavior of Migrating Cortical Interneurons in the Marginal Zone: Time-Lapse Analysis in Flat-Mount Cortex

Daisuke H. Tanaka, Mitsutoshi Yanagida, Yan Zhu, Sakae Mikami, Takashi Nagasawa, Jun-ichi Miyazaki, Yuchio Yanagawa, Kunihiko Obata, Fujio Murakami

JOURNAL OF NEUROSCIENCE　Vol. 29　No. 5　p. 1300-1311　2009/02　Research paper (scientific journal)

Electrotransfer of plasmid vector DNA into muscle

Satsuki Miyazaki, Jun-Ichi Miyazaki

Electroporation and Sonoporation in Developmental Biology　p. 249-262　2009　Part of collection (book)

Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia

Shuichi Toyoda, Tatsushi Miyazaki, Satsuki Miyazaki, Takuji Yoshimura, Mayu Yamamoto, Fumi Tashiro, Eiji Yamato, Jun-ichi Miyazaki

DEVELOPMENTAL BIOLOGY　Vol. 325　No. 1　p. 238-248　2009/01　Research paper (scientific journal)

Enrichment of undifferentiated mouse embryonic stem cells on a culture surface with a glucose-displaying dendrimer

Shohreh Mashayekhan, Mee Hae Kim, Satsuki Miyazaki, Fumi Tashiro, Masahiro Kino-oka, Masahito Taya, Jun ichi Miyazaki

Biomaterials　Vol. 29　No. 31　p. 4236-4243　2008/11　Research paper (scientific journal)

In vivo DNA electrotransfer into muscle

Satsuki Miyazaki, Jun-Ichi Miyazaki

DEVELOPMENT GROWTH & DIFFERENTIATION　Vol. 50　No. 6　p. 479-483　2008/08

Electroporation-mediated transfer of plasmid DNA encoding IL-10 attenuates orthotopic tracheal allograft stenosis in rats

Masanori Tsuchida, Terumoto Koike, Masaru Takekubo, Hiroyuki Hirahara, Haruo Hanawa, Hiroki Maruyama, Jun-ichi Miyazaki, Jun-ichi Hayashi

TRANSPLANT IMMUNOLOGY　Vol. 19　No. 3-4　p. 173-177　2008/07　Research paper (scientific journal)

Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer

He Chang, Haruo Hanawa, Tsuyoshi Yoshida, Manabu Hayashi, Hui Liu, Limin Ding, Keita Otaki, Kazuhisa Hao, Kaori Yoshida, Kiminori Kato, Ken Toba, Makoto Kodama, Hiroki Maruyama, Junichi Miyazaki, Yoshifusa Aizawa

CIRCULATION JOURNAL　Vol. 72　No. 5　p. 813-819　2008/05　Research paper (scientific journal)

Hydrodynamics-based delivery of plasmid DNA encoding CTLA4-1g prolonged cardiac allograft survival in rats

Masaru Takekubo, Masanori Tsuchida, Manabu Haga, Masayuki Saitoh, Haruo Hanawa, Hiroki Maruyama, Jun-ichi Miyazaki, Jun-ichi Hayashi

JOURNAL OF GENE MEDICINE　Vol. 10　No. 3　p. 290-297　2008/03　Research paper (scientific journal)

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

Suguru Yamaguchi, Hisamitsu Lshihara, Takahiro Yamada, Akira Tamura, Masahiro Iusui, Ryu Tominaga, Yuichiro Munakata, Chihiro Satake, Hideki Katagiri, Fumi Tashiro, Hiroyuki Aburatani, Kyoko Tsukiyama-Kohara, Jun-ichi Miyazaki, Nahum Sonenberg, Yoshitomo Oka

CELL METABOLISM　Vol. 7　No. 3　p. 269-276　2008/03　Research paper (scientific journal)

Pdx-1-independent differentiation of mouse embryonic stem cells into insulin-expressing cells

I. Takayama, S. Miyazaki, F. Tashiro, J. Fujikura, J. Miyazaki, E. Yamato

Diabetes Research and Clinical Practice　Vol. 79　No. 2　p. e8-e10　2008/02　Research paper (scientific journal)

Novel mutations of the GLA gene in Japanese patients with Fabry disease and their functional characterization by active site specific chaperone

Masaaki Shimotori, Hiroki Maruyama, Gen Nakamura, Takayuki Suyama, Fumiko Sakamoto, Masaaki Itoh, Shigeaki Miyabayashi, Takahiro Ohnishi, Norio Sakai, Mari Wataya-Kaneda, Mitsuru Kubota, Toshiyuki Takahashi, Tatsuhiko Mori, Katsuhiko Tamura, Shinji Kageyama, Nobuo Shio, Teruhiko Maeba, Hirokazu Yahagi, Motoko Tanaka, Masayo Oka, Hitoshi Sugiyama, Toshiyuki Sugawara, Noriko Mori, Hiroko Tsukamoto, Keiichi Tamagaki, Shuuji Tanda, Yuka Suzuki, Chiya Shinonaga, Jun-Ichi Miyazaki, Satoshi Ishii, Fumitake Gejyo

HUMAN MUTATION　Vol. 29　No. 2　p. 331-331　2008/02　Research paper (scientific journal)

Naked plasmid DNA-based alpha-galactosidase A gene transfer partially reduces systemic accumulation of globotriaosylceramide in Fabry mice

Gen Nakamura, Hiroki Maruyama, Satoshi Ishii, Masaaki Shimotori, Shigemi Kameda, Toru Kono, Jun-Ichi Miyazaki, Ashok B. Kulkarni, Fumitake Gejyo

MOLECULAR BIOTECHNOLOGY　Vol. 38　No. 2　p. 109-119　2008/02　Research paper (scientific journal)

D-グルコース提示面による細胞形態変化の機構解析と細胞集塊形成培養への応用

金 美海, 紀ノ岡 正博, Mashayekhan Shoreh, 宮崎 純一, 田谷 正仁

化学工学会 研究発表講演要旨集　Vol. 2008　p. 301-301　2008

Hyperplastic islets observed in "reversed" NOD mice treated without hematopoietic cells

Yoshiaki Okubo, Akira Shimada, Yasuhiko Kanazawa, Toshikatsu Shigihara, Yoichi Oikawa, Takatoshi Imai, Junichi Miyazaki, Hiroshi Itoh

DIABETES RESEARCH AND CLINICAL PRACTICE　Vol. 79　No. 1　p. 18-23　2008/01　Research paper (scientific journal)

Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus

Mayu Yamamoto, Eiji Yamato, Shu-Ichi Toyoda, Fumi Tashiro, Hiroshi Ikegami, Junji Yodoi, Jun-Ichi Miyazaki

ANTIOXIDANTS & REDOX SIGNALING　Vol. 10　No. 1　p. 43-49　2008/01　Research paper (scientific journal)

Hepatocyte growth factor gene therapy for hypertension.

Komamura K, Miyazaki J, Imai E, Matsumoto K, Nakamura T, Hori M

Methods in molecular biology (Clifton, N.J.)　Vol. 423　p. 393-404　2008　Research paper (scientific journal)

Gene expression pattern of Cue110: A member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells

Takuji Yoshimura, Tatsushi Miyazaki, Shuichi Toyoda, Satsuki Miyazaki, Fumi Tashiro, Eiji Yamato, Jun-ichi Miyazaki

GENE EXPRESSION PATTERNS　Vol. 8　No. 1　p. 27-35　2007/12　Research paper (scientific journal)

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by CAMP

Tadao Shibasaki, Harumi Takahashi, Takashi Miki, Yasuhiro Sunaga, Kimio Matsumura, Mami Yamanaka, Changliang Zhang, Atsuko Tamamoto, Takaya Satoh, Jun-ichi Miyazaki, Susumu Seinon

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 49　p. 19333-19338　2007/12　Research paper (scientific journal)

Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro

Masafumi Shimoda, Masami Kanai-Azuma, Kenshiro Hara, Satsuki Miyazaki, Yoshiakira Kanai, Morito Monden, Jun-ichi Miyazaki

JOURNAL OF CELL SCIENCE　Vol. 120　No. 21　p. 3859-3869　2007/11　Research paper (scientific journal)

Both Pdx-1 and NeuroD1 genes are requisite for the maintenance of insulin gene expression in ES-derived differentiated cells

Koichi Saitoh, Eiji Yamato, Satsuki Miyazaki, Jun-Ichi Miyazaki

DIABETES RESEARCH AND CLINICAL PRACTICE　Vol. 77　p. S138-S142　2007/09　Research paper (scientific journal)

Gender difference in ICER I gamma Transgenic diabetic mouse

Akari Inada, Hidenori Arai, Kojiro Nagai, Jun-ichi Miyazaki, Yuichiro Yamada, Yutaka Seino, Atsushi Fukatsu

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　Vol. 71　No. 8　p. 1920-1926　2007/08　Research paper (scientific journal)

Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2c)

Fengxia Ge, Junjie Yao, Xiaoying Fu, Zhanjun Guo, Jingmin Yan, Beiru Zhang, Huanyu Zhang, Hiroshi Tomozawa, Junichi Miyazaki, Jinko Sawashita, Masayuki Mori, Keiichi Higuchi

Laboratory Investigation　Vol. 87　No. 7　p. 633-643　2007/07/05　Research paper (scientific journal)

Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development

Hideki Yuzuriha, Akio Inui, Akihiro Asakawa, Naohiko Ueno, Masato Kasuga, Michael M. Meguid, Jun-ichi Miyazaki, Maiko Ninomiya, Herbert Herzog, Mineko Fujimiya

FASEB JOURNAL　Vol. 21　No. 9　p. 2108-2112　2007/07　Research paper (scientific journal)

Disruption of the mouse protein Ser/Thr phosphatase 2C beta gene leads to early pre-implantation lethality

Masato Sasaki, Motoko Ohnishi, Fumi Tashiro, Hitoshi Niwa, Akira Suzuki, Jun-ichi Miyazaki, Takayasu Kobayashi, Shinri Tamura

MECHANISMS OF DEVELOPMENT　Vol. 124　No. 6　p. 489-499　2007/07　Research paper (scientific journal)

IL-5-induced hypereosinophilia suppiresses the antigen-induced immune response via a TGF-beta-dependent mechanism

Kazuyuki Nakagome, Makoto Dohi, Katsuhide Okunishi, Ryoichi Tanaka, Taku Kouro, Mitsunobu R. Kano, Kohei Miyazono, Jun-ichi Miyazaki, Kiyoshi Takatsu, Kazuhiko Yamamoto

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 1　p. 284-294　2007/07　Research paper (scientific journal)

Activating Fc gamma receptors participate in the development of autoimmune diabetes in NOD mice

Yoshihiro Inoue, Tomonori Kaifu, Akiko Sugahara-Tobinai, Akira Nakamura, Jun-Ichi Miyazaki, Toshiyuki Takai

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 2　p. 764-774　2007/07　Research paper (scientific journal)

Metabolic disorders in diabetes mellitus: Impact of mitochondrial function and oxidative stress on diabetes and its complications

Eiichi Araki, Jun-Ichi Miyazaki

ANTIOXIDANTS & REDOX SIGNALING　Vol. 9　No. 3　p. 289-291　2007/03

Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart

Kouji Komatsu, Shuji Wakatsuki, Shu-ichi Yamada, Ken-ichi Yamamura, Jun-ichi Miyazaki, Atsuko Sehara-Fujisawa

DEVELOPMENTAL BIOLOGY　Vol. 303　No. 1　p. 82-92　2007/03　Research paper (scientific journal)

Anti-oxidative effect of Klotho on endothelial cells through cAMP activation

Hiromi Rakugi, Naomichi Matsukawa, Kazuhiko Ishikawa, Jin Yang, Michio Imai, Masashi Ikushima, Yoshihiro Maekawa, Iwao Kida, Jun-Ichi Miyazaki, Toshio Ogihara

ENDOCRINE　Vol. 31　No. 1　p. 82-87　2007/02　Research paper (scientific journal)

Anti-oxidative effect of Klotho on endothelial cells through cAMP activation.

Hiromi Rakugi, Naomichi Matsukawa, Kazuhiko Ishikawa, Jin Yang, Michio Imai, Masashi Ikushima, Yoshihiro Maekawa, Iwao Kida, Jun-ichi Miyazaki, Toshio Ogihara

Endocrine　Vol. 31　No. 1　p. 82-7　2007/02

Protection against CC1(4)-induced injury in liver by adenovirally introduced thioredoxin gene

Katsuhiro Isoda, Eri Arita, Midori Kojima, Masahiro Ikkaku, Fumi Tashiro, Eiji Yamato, Jun-Ichi Miyazaki, Masaya Kawase, Masuo Kondoh, Kiyohito Yagi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 350　No. 1　p. 157-161　2006/11　Research paper (scientific journal)

Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells

Yuhki Nakatake, Nobutaka Fukui, Yuko Iwamatsu, Shinji Masui, Kadue Takahashi, Rika Yagi, Kiyohito Yagi, Jun-ichi Miyazaki, Ryo Matoba, Minoru S. H. Ko, Hitoshi Niwa

MOLECULAR AND CELLULAR BIOLOGY　Vol. 26　No. 20　p. 7772-7782　2006/10　Research paper (scientific journal)

In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-beta in the lung

K. Nakagome, M. Dohi, K. Okunishi, R. Tanaka, J. Miyazaki, K. Yamamoto

THORAX　Vol. 61　No. 10　p. 886-894　2006/10　Research paper (scientific journal)

Stimulation of cAMP signalling allows isolation of clonal pancreatic precursor cells from adult mouse pancreas

T. Yamamoto, E. Yamato, H. Taniguchi, M. Shimoda, F. Tashiro, M. Hosoi, T. Sato, S. Fujii, J. -I. Miyazaki

DIABETOLOGIA　Vol. 49　No. 10　p. 2359-2367　2006/10　Research paper (scientific journal)

Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats

He Chang, Haruo Hanawa, Hui Liu, Tsuyoshi Yoshida, Manabu Hayashi, Ritsuo Watanabe, Satoru Abe, Ken Toba, Kaori Yoshida, Raafat Elnaggar, Shiro Minagawa, Yuji Okura, Kiminori Kato, Makoto Kodama, Hiroki Maruyama, Junichi Miyazaki, Yoshifusa Aizawa

Journal of Immunology　Vol. 177　No. 6　p. 3635-3643　2006/09/15　Research paper (scientific journal)

Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases

Sachiko Kanakubo, Tadashi Nomura, Ken-ichi Yamamura, Jun-ichi Miyazaki, Makoto Tamai, Noriko Osumi

GENES TO CELLS　Vol. 11　No. 8　p. 919-933　2006/08　Research paper (scientific journal)

Simultaneous gene transfer of bone morphogenetic protein (BMP)-2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression

Mariko Kawai, Kazuhisa Bessho, Hiroki Maruyama, Jun-ichi Miyazaki, Toshio Yamamoto

BMC MUSCULOSKELETAL DISORDERS　Vol. 7　2006/08　Research paper (scientific journal)

Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells

T Yokoi, K Fukuo, O Yasuda, M Hotta, J Miyazaki, Y Takemura, H Kawamoto, H Ichijo, T Ogihara

DIABETES　Vol. 55　No. 6　p. 1660-1665　2006/06　Research paper (scientific journal)

Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver

T Hanawa, K Suzuki, Y Kawauchi, M Takamura, H Yoneyama, GD Han, H Kawachi, F Shimizu, H Asakura, J Miyazaki, H Maruyama, Y Aoyagi

JOURNAL OF GENE MEDICINE　Vol. 8　No. 5　p. 623-635　2006/05　Research paper (scientific journal)

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

T Yamada, H Ishihara, A Tamura, R Takahashi, S Yamaguchi, D Takei, A Tokita, C Satake, F Tashiro, H Katagiri, H Aburatani, J Miyazaki, Y Oka

HUMAN MOLECULAR GENETICS　Vol. 15　No. 10　p. 1600-1609　2006/05　Research paper (scientific journal)

Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: Role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel

M Kawajiri, Y Okano, M Kuno, D Tokuhara, Y Hase, H Inada, F Tashiro, JI Miyazaki, T Yamano

PEDIATRIC RESEARCH　Vol. 59　No. 3　p. 359-364　2006/03　Research paper (scientific journal)

Effects of viral interleukin 10 introduced by in vivo electroporation on arthrogen-induced arthritis in mice.

Kuroda, T, Maruyama, H, Shimotori, M, Higuchi, N, Kameda, S, Tahara, H, Miyazaki, J, Gejyo, F

J. Rheumatol.　Vol. 33: 455-462　2006/02　Research paper (scientific journal)

Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: Preservation of acetylated chromatin

A Nishiyama, A Dey, J Miyazaki, K Ozato

MOLECULAR BIOLOGY OF THE CELL　Vol. 17　No. 2　p. 814-823　2006/02　Research paper (scientific journal)

Investigation of the fate of Sry-expressing cells using an in vivo Cre/loxP system

M Ito, K Yokouchi, K Yoshida, K Kano, K Naito, JI Miyazaki, H Tojo

DEVELOPMENT GROWTH & DIFFERENTIATION　Vol. 48　No. 1　p. 41-47　2006/01　Research paper (scientific journal)

Development of a single-cassette system for spatiotemporal gene regulation in mice

Satsuki Miyazaki, Tatsushi Miyazaki, Fumi Tashiro, Eiji Yamato, Jun-Ichi Miyazaki

Biochemical and Biophysical Research Communications　Vol. 338　No. 2　p. 1083-1088　2005/12/16　Research paper (scientific journal)

Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice

Eisei Sohara, Tatemitsu Rai, Jun-ichi Miyazaki, A. S. Verkman, Sei Sasaki, Shinichi Uchida

American Journal of Physiology-Renal Physiology　Vol. 289　No. 6　p. F1195-F1200　2005/12　Research paper (scientific journal)

Human BMP-2 gene transfer using transcutaneous in vivo electroporation induced both intramembranous and endochondral ossification

Mariko Kawai, Kazuhisa Bessho, Hiroki Maruyama, Jun-Ichi Miyazaki, Toshio Yamamoto

Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology　Vol. 287　No. 2　p. 1264-1271　2005/12　Research paper (scientific journal)

CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice

T Shigihara, A Shimada, Y Oikawa, H Yoneyama, Y Kanazawa, Y Okubo, K Matsushima, E Yamato, J Miyazaki, A Kasuga, T Saruta, S Narumi

JOURNAL OF IMMUNOLOGY　Vol. 175　No. 12　p. 8401-8408　2005/12　Research paper (scientific journal)

Human BMP-2 gene transfer using transcutaneous in vivo electroporation induced both intramembranous and endochondral ossification

M Kawai, K Bessho, H Maruyama, JI Miyazaki, T Yamamoto

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY　Vol. 287A　No. 2　p. 1264-1271　2005/12　Research paper (scientific journal)

Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice

E Sohara, T Rai, J Miyazaki, AS Verkman, S Sasaki, S Uchida

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 289　No. 6　p. F1195-F1200　2005/12　Research paper (scientific journal)

Detection of elements responsible for stage- and tissue-specific expression of mouse Sry using an in vitro Cre/loxP system

M Ito, K Yokouchi, K Naito, H Endo, Y Hakamata, J Miyazaki, H Tojo

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 337　No. 1　p. 264-270　2005/11　Research paper (scientific journal)

Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion

A Salehi, E Flodgren, NE Nilsson, J Jimenez-Feltstrom, J Miyazaki, C Owman, B Olde

CELL AND TISSUE RESEARCH　Vol. 322　No. 2　p. 207-215　2005/11　Research paper (scientific journal)

A novel role of hepatocyte growth regulator through suppressing factor as an immune dendritic cell function

K Okunishi, M Dohi, K Nakagome, R Tanaka, S Mizuno, K Matsumoto, J Miyazaki, T Nakamura, K Yamamoto

JOURNAL OF IMMUNOLOGY　Vol. 175　No. 7　p. 4745-4753　2005/10　Research paper (scientific journal)

Hex stimulates the hepatocyte nuclear factor 1alpha-mediated activation of transcription.

Hironori Tanaka, Taichi Yamamoto, Tomoko Ban, Shin-ichi Satoh, Takashi Tanaka, Masafumi Shimoda, Jun-ichi Miyazaki, Tamio Noguchi

Archives of biochemistry and biophysics　Vol. 442　No. 1　p. 117-24　2005/10/01　Research paper (scientific journal)

Polyethyleneimine/chitosan hexamer-mediated gene transfection into intestinal epithelial cell cultured in serum-containing medium.

Ouji, Y, Yoshida-Terakura, A, Hayashi, Y, Maeda, I, Kawase, M, Yamato, E, Miyazaki, J, Yagi, K

J. Biosci. Bioeng.　Vol. 94: 81-83　2005/10　Research paper (scientific journal)

A CMV-actin-globin hybrid promoter improves adeno-associated viral vector gene expression in the arterial wall in vivo

Y Nitta, S Kawamoto, C Halbert, A Iwata, AD Miller, J Miyazaki, MD Allen

JOURNAL OF GENE MEDICINE　Vol. 7　No. 10　p. 1348-1355　2005/10　Research paper (scientific journal)

Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked plasmid DNA encoding CTLA4-Ig gene delivery

S Abe, M Hanawa, M Hayashi, M Yoshida, S Komura, R Watanabe, H Lie, H Chang, K Kato, M Kodama, M Maruyama, M Nakazawa, J Miyazaki, Y Aizawa

JOURNAL OF CARDIAC FAILURE　Vol. 11　No. 7　p. 557-564　2005/09　Research paper (scientific journal)

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

K Hamada, T Sasaki, PA Koni, M Natsui, H Kishimoto, J Sasaki, N Yajima, Y Horie, G Hasegawa, M Naito, J Miyazaki, T Suda, H Itoh, K Nakao, TW Mak, T Nakano, A Suzuki

GENES & DEVELOPMENT　Vol. 19　No. 17　p. 2054-2065　2005/09　Research paper (scientific journal)

Cancer gene therapy using in vivo electroporation of Flt3-ligand.

Shimao, K, Takayama, T, Enomoto, K, Saito, T, Nagai, S, Miyazaki, J, Ogawa, K, Tahara, H

Int. J. Oncol.　Vol. 27: 457-463　2005/09　Research paper (scientific journal)

Protective role for cytosolic phospholipase A(2)alpha in autoimmune diabetes of mice

Y Oikawa, E Yamato, F Tashiro, M Yamamoto, N Uozumi, A Shimada, T Shimizu, J Miyazaki

FEBS LETTERS　Vol. 579　No. 18　p. 3975-3978　2005/07　Research paper (scientific journal)

Widespread and early myocardial gene expression by adeno-associated virus vector type 6 with a beta-actin hybrid promoter

S Kawamoto, Q Shi, Y Nitta, J Miyazaki, MD Allen

MOLECULAR THERAPY　Vol. 11　No. 6　p. 980-985　2005/06　Research paper (scientific journal)

The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism

R Elnaggar, H Hanawa, H Liu, T Yoshida, M Hayashi, R Watanabe, S Abe, K Toba, K Yoshida, H Chang, S Minagawa, Y Okura, K Kato, M Kodama, H Maruyama, J Miyazaki, Y Aizawa

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 35　No. 6　p. 1995-2005　2005/06　Research paper (scientific journal)

In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation

K Nakagome, M Dohi, K Okunishi, Y Komagata, K Nagatani, R Tanaka, J Miyazaki, K Yamamoto

JOURNAL OF IMMUNOLOGY　Vol. 174　No. 11　p. 6955-6966　2005/06　Research paper (scientific journal)

Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBP beta gene

K Isoda, H Koide, M Kojima, E Arita, M Ikkaku, S Higashiyama, F Tashiro, E Yamato, JI Miyazaki, M Kawase, K Yagi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 329　No. 1　p. 182-187　2005/04　Research paper (scientific journal)

Effect of hydrodynamics-based gene delivery of plasmid DNA encoding interleukin-1 receptor antagonist-Ig for treatment of rat autoimmune myocarditis - Possible mechanism for lymphocytes and noncardiac cells

H Liu, H Hanawa, T Yoshida, R Elnaggar, M Hayashi, R Watanabe, K Toba, K Yoshida, H Chang, Y Okura, K Kato, M Kodama, H Maruyama, J Miyazaki, M Nakazawa, Y Aizawa

CIRCULATION　Vol. 111　No. 13　p. 1593-1600　2005/04　Research paper (scientific journal)

Sustained transgene expression in rat kidney with naked plasmid DNA and PCR-amplified DNA fragments

H Maruyama, N Higuchi, S Kameda, G Nakamura, M Shimotori, N Iino, M Higuchi, T Neichi, S Yokoyama, T Kono, J Miyazaki, F Gejyo

JOURNAL OF BIOCHEMISTRY　Vol. 137　No. 3　p. 373-380　2005/03　Research paper (scientific journal)

Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells

M Hirose, H Hashimoto, N Shintani, M Nakanishi, N Arakawa, J Iga, H Niwa, J Miyazaki, A Baba

REGULATORY PEPTIDES　Vol. 126　No. 1-2　p. 109-113　2005/03　Research paper (scientific journal)

Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization

H Kanda, Y Tamori, H Shinoda, M Yoshikawa, M Sakaue, J Udagawa, H Otani, F Tashiro, J Miyazaki, M Kasuga

JOURNAL OF CLINICAL INVESTIGATION　Vol. 115　No. 2　p. 291-301　2005/02　Research paper (scientific journal)

Establishment of a diabetic mouse model with progressive diabetic nephropathy

Akari Inada, Kojiro Nagai, Hidenori Arai, Jun-Ichi Miyazaki, Keiko Nomura, Hiroshi Kanamori, Shinya Toyokuni, Yuichiro Yamada, Susan Bonner-Weir, Gordon C. Weir, Atsushi Fukatsu, Yutaka Seino

American Journal of Pathology　Vol. 167　No. 2　p. 327-336　2005　Research paper (scientific journal)

The testicular fatty acid binding protein PERF15 regulates the fate of germ cells in PERF15 transgenic mice

Tatsuo Kido, Satoru Arata, Ryusuke Suzuki, Tomohiko Hosono, Yoshinobu Nakanishi, Jun-Icni Miyazaki, Izumu Saito, Toshio Kuroki, Seiji Shioda

Development Growth and Differentiation　Vol. 47　No. 1　p. 15-24　2005/01　Research paper (scientific journal)

p38 alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload

K Nishida, O Yamaguchi, S Hirotani, S Hikoso, Y Higuchi, T Watanabe, T Takeda, S Osuka, T Morita, G Kondoh, Y Uno, K Kashiwase, M Taniike, A Nakai, Y Matsumura, J Miyazaki, T Sudo, K Hongo, Y Kusakari, S Kurihara, KR Chien, J Takeda, M Hori, K Otsu

MOLECULAR AND CELLULAR BIOLOGY　Vol. 24　No. 24　p. 10611-10620　2004/12　Research paper (scientific journal)

Protective effect of montmorillonite on plasmid DNA in oral gene delivery into small intestine

M Kawase, Y Hayashi, F Kinoshita, EY Yamato, J Miyazaki, J Yamakawa, T Ishida, M Tamura, K Yagi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 27　No. 12　p. 2049-2051　2004/12　Research paper (scientific journal)

TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells

U Funfschilling, YG Ng, KL Zang, J Miyazaki, LF Reichardt, FL Rice

JOURNAL OF COMPARATIVE NEUROLOGY　Vol. 480　No. 4　p. 392-414　2004/12　Research paper (scientific journal)

IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice

M Shiraki, H Aihara, Y Kinouchi, S Takahashi, M Oki, M Noguchi, K Takahashi, J Miyazaki, T Shimosegawa

LABORATORY INVESTIGATION　Vol. 84　No. 11　p. 1491-1500　2004/11　Research paper (scientific journal)

Needleless in vivo gene transfer into muscles by jet injection in combination with electroporation

Mayumi Horiki, Eiji Yamato, Hiroshi Ikegami, Toshio Ogihara, Jun-Ichi Miyazaki

Journal of Gene Medicine　Vol. 6　No. 10　p. 1134-1138　2004/10　Research paper (scientific journal)

Epidermis-targeted gene transfer using in vivo electroporation.

Maruyama, H, Miyazaki, J, Gejyo, F

In Methods in Molecular Biology, vol. 289: Epidermis Cells: Methods and Protocols. Turksen, K. ed. (Hamana Press, Totowa, New Jersey).　2004/10　Research paper (scientific journal)

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

O Yamaguchi, T Watanabe, K Nishida, K Kashiwase, Y Higuchi, T Takeda, S Hikoso, S Hirotani, M Asahi, M Taniike, A Nakai, Tsujimoto, I, Y Matsumura, J Miyazaki, KR Chien, A Matsuzawa, C Sadamitsu, H Ichijo, M Baccarini, M Hori, K Otsu

JOURNAL OF CLINICAL INVESTIGATION　Vol. 114　No. 7　p. 937-943　2004/10　Research paper (scientific journal)

Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice

N Matsushita, K Kobayashi, J Miyazaki, K Kobayashi

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 78　No. 1　p. 7-15　2004/10　Research paper (scientific journal)

Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle

K Komamura, R Tatsumi, J Miyazaki, K Matsumoto, E Yamato, T Nakamura, Y Shimizu, T Nakatani, S Kitamura, H Tomoike, M Kitakaze, K Kangawa, K Miyatake

HYPERTENSION　Vol. 44　No. 3　p. 365-371　2004/09　Research paper (scientific journal)

NO合成酵素遺伝子導入による肝線維化抑制効果の検討

河野 透, 丸山 弘樹, 海老澤 良昭, 浅間 俊之, 千里 直之, 今村 恵美, 大澤 高陽, 菅原 睦, 柏手 由里乃, 下条 文武, 宮崎 純一, 葛西 眞一

新潟医学会雑誌　Vol. 118　No. 8　p. 441-441　2004/08

Muscle-targeted interleukin-12 gene therapy of orthotopic hepatocellular carcinoma in mice using in vivo electrosonoporation.

Yamashita, Y, Shimada, M, Minagawa, R, Tsujita, E, Harimoto, N, Tanaka, S, Shirabe, K, Miyazaki, J, Maehara, Y

Mol. Cancer Ther.　Vol. 3: 1177-1182　2004/07　Research paper (scientific journal)

IL-5-induced eosinophils suppress the growth of Leishmania amazonensis in vivo and kill promastigotes in vitro in response to either IL-4 or IFN-γ

Yoshiya Watanabe, Emi Hamaguchi-Tsuru, Norihito Morimoto, Youhei Nishio, Ken-Ichi Yagyu, Yuko Konishi, Mari Tominaga, Jun-Ichi Miyazaki, Masato Furuya, Akira Tominaga

DNA and Cell Biology　Vol. 23　No. 7　p. 412-418　2004/07　Research paper (scientific journal)

Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression

N Nakajima-Nagata, M Sugai, T Sakurai, J Miyazaki, YH Tabata, A Shimizu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 318　No. 3　p. 631-635　2004/06　Research paper (scientific journal)

In vitro induction of adult hepatic progenitor cells into insulin-producing cells

N Nakajima-Nagata, T Sakurai, T Mitaka, T Katakai, E Yamato, J Miyazaki, Y Tabata, M Sugai, A Shimizu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 318　No. 3　p. 625-630　2004/06　Research paper (scientific journal)

Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I

Y Oshima, K Sato, F Tashiro, J Miyazaki, K Nishida, Y Hiraki, Y Tano, C Shukunami

JOURNAL OF CELL SCIENCE　Vol. 117　No. 13　p. 2731-2744　2004/06　Research paper (scientific journal)

Interaction between Hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling

T Minami, T Murakami, K Horiuchi, M Miura, T Noguchi, J Miyazaki, T Hamakubo, WC Aird, T Kodama

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 20　p. 20626-20635　2004/05　Research paper (scientific journal)

Site-specific kidney-targeted plasmid DNA transfer using nonviral techniques.

Maruyama, H, Higuchi, N, Kameda, S, Nakamura, G, Miyazaki, J, Gejyo, F

Gene Ther. Mol. Biol.　Vol. 7: 221-228　2004/04　Research paper (scientific journal)

Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase

Kobayashi, K, Takahashi, M, Matsushita, N, Miyazaki, J, Koike, M, Yaginuma, H, Ohsumi, N, Kaibuchi, K, Kobayashi, K

JOURNAL OF NEUROSCIENCE　Vol. 24: 3480-3488　2004/04　Research paper (scientific journal)

Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells

A Inada, Y Hamamoto, Y Tsuura, J Miyazaki, S Toyokuni, Y Ihara, K Nagai, Y Yamada, S Bonner-Weir, Y Seino

MOLECULAR AND CELLULAR BIOLOGY　Vol. 24　No. 7　p. 2831-2841　2004/04　Research paper (scientific journal)

A novel method to assay proteins in blood plasma after intravenous injection of plasmid DNA

H Hanawa, R Watanabe, M Hayashi, T Yoshida, S Abe, S Komura, H Liu, R Elnaggar, H Chang, Y Okura, K Kato, M Kodama, H Maruyama, J Miyazaki, Y Aizawa

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 202　No. 3　p. 155-161　2004/03　Research paper (scientific journal)

Identification of the Transactivating Region of the Homeodomain Protein, Hex

Shinya Kasamatsu, Ayuko Sato, Taichi Yamamoto, Vincent W. Keng, Hiroshi Yoshida, Yuka Yamazaki, Masafumi Shimoda, Jun Ichi Miyazaki, Tamio Noguchi

Journal of Biochemistry　Vol. 135　No. 2　p. 217-223　2004/02　Research paper (scientific journal)

Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells.

Miyazaki, S, Yamato, E, Miyazaki, J

Diabetes　Vol. 53: 1030-1037　p. 1030-1037　2004/02　Research paper (scientific journal)

Rat liver-targeted naked plasmid DNA transfer by tail vein injection

H Maruyama, N Higuchi, S Kameda, J Miyazaki, F Gejyo

MOLECULAR BIOTECHNOLOGY　Vol. 26　No. 2　p. 165-172　2004/02　Research paper (scientific journal)

Post-secretion neutralization of transgene-derived effect: soluble erythropoietin receptor/IgG(1)Fc expressed in liver neutralizes erythropoietin produced in muscle

H Maruyama, M Higuchi, N Higuchi, S Kameda, M Saito, M Sugawa, J Matsuzaki, T Neichi, S Yokoyama, Y Miyazaki, Y Miyazaki, F Gejyo

JOURNAL OF GENE MEDICINE　Vol. 6　No. 2　p. 228-237　2004/02　Research paper (scientific journal)

Lamr1 functional retroposon causes right ventricular dysplasia in mice

Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, H Asanuma, S Sanada, J Kim, A Ogai, T Fukushima, Y Oikawa, Y Okazaki, Y Kaneda, M Sato, J Miyazaki, S Kitamura, H Tomoike, M Kitakaze, M Hori

NATURE GENETICS　Vol. 36　No. 2　p. 123-130　2004/02　Research paper (scientific journal)

Kidney-targeted naked DNA transfer by retrograde injection into the renal vein in mice

S Kameda, H Maruyama, N Higuchi, N Iino, G Nakamura, J Miyazaki, F Gejyo

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 314　No. 2　p. 390-395　2004/02　Research paper (scientific journal)

Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice

T Yamamoto, E Yamato, F Tashiro, T Sato, S Noso, H Ikegami, S Tamura, Y Yanagawa, JI Miyazaki

DIABETOLOGIA　Vol. 47　No. 2　p. 221-224　2004/02　Research paper (scientific journal)

Rat kidney-targeted naked plasmid DNA transfer by retrograde injection into the renal vein

Hiroki Maruyama, Noboru Higuchi, Shigemi Kameda, Gen Nakamura, Seitaro Iguchi, Jun-Ichi Miyazaki, Fumitake Gejyo

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology　Vol. 27　No. 1　p. 23-31　2004　Research paper (scientific journal)

Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse

N Tamamaki, Y Yanagawa, R Tomioka, JI Miyazaki, K Obata, T Kaneko

JOURNAL OF COMPARATIVE NEUROLOGY　Vol. 467　No. 1　p. 60-79　2003/12　Research paper (scientific journal)

Nonviral gene gun mediated transfer into the beating heart

Y Matsuno, H Iwata, Y Umeda, H Takagi, Y Mori, J Miyazaki, A Kosugi, H Hirose

ASAIO JOURNAL　Vol. 49　No. 6　p. 641-644　2003/11　Research paper (scientific journal)

Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice.

Oikawa, Y, Shimada, A, Kasuga, A, Morimoto, J, Osaki, T, Tahara, H, Miyazaki, T, Tashiro, F, Yamato, E, Miyazaki, J, Saruta, T

J. Immunol.　Vol. 171: 5865-5875　2003/11　Research paper (scientific journal)

Essential role for ERK2 mitogen-activated protein kinase in placental development

N Hatano, Y Mori, M Oh-Hora, A Kosugi, T Fujikawa, N Nakai, H Niwa, J Miyazaki, T Hamaoka, M Ogata

GENES TO CELLS　Vol. 8　No. 11　p. 847-856　2003/11　Research paper (scientific journal)

Analysis of cell lineage in two- and four-cell mouse embryos

T Fujimori, Y Kurotaki, J Miyazaki, Y Nabeshima

DEVELOPMENT　Vol. 130　No. 21　p. 5113-5122　2003/11　Research paper (scientific journal)

Long-term control of food intake and body weight by hydrodynamics-based delivery of plasmid DNA encoding leptin or CNTF

JJ Jiang, E Yamato, J Miyazaki

JOURNAL OF GENE MEDICINE　Vol. 5　No. 11　p. 977-983　2003/11　Research paper (scientific journal)

Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium

Eun Jeong Park, Ichiro Takahashi, Junko Ikeda, Kazuko Kawahara, Tetsuji Okamoto, Mi-Na Kweon, Satoshi Fukuyama, Veronika Groh, Thomas Spies, Yuichi Obata, Jun-Ichi Miyazaki, Hiroshi Kiyono

Journal of Immunology　Vol. 171　No. 8　p. 4131-4139　2003/10/15　Research paper (scientific journal)

Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis

T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, Y Arakawa, Y Fujitani, Y Umayahara, H Watada, Y Yamasaki, MA Magnuson, J Miyazaki, M Hori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 310　No. 3　p. 1017-1025　2003/10　Research paper (scientific journal)

Hydrodynamics-based transfer of PCR-amplified DNA fragments into rat liver

S Kameda, H Maruyama, G Nakamura, N Iino, Y Nishikawa, J Miyazaki, F Gejyo

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 309　No. 4　p. 929-936　2003/10　Research paper (scientific journal)

Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy

Takafumi Koga, Hidenori Urata, Yukiko Inoue, Takafumi Hoshino, Takehiro Okamoto, Akira Matsunaga, Misao Suzuki, Junichi Miyazaki, Munehito Ideishi, Kikuo Arakawa, Keijiro Saku

Hypertension Research　Vol. 26　No. 9　p. 759-768　2003/09/01　Research paper (scientific journal)

Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice

H Hasegawa, M Kohno, M Sasaki, A Inoue, MR Ito, M Terada, K Hieshima, H Maruyama, JI Miyazaki, O Yoshie, M Nose, S Fujita

ARTHRITIS AND RHEUMATISM　Vol. 48　No. 9　p. 2555-2566　2003/09　Research paper (scientific journal)

Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure

K Ataka, H Maruyama, T Neichi, J Miyazaki, F Gejyo

AMERICAN JOURNAL OF NEPHROLOGY　Vol. 23　No. 5　p. 315-323　2003/09　Research paper (scientific journal)

Structural and functional characterization of mouse glutamate decarboxylase 67 gene promoter.

Takashi Kobayashi, Satoe Ebihara, Kenji Ishii, Takayasu Kobayashi, Michiharu Nishijima, Shunro Endo, Akira Takaku, Hiroyuki Sakagami, Hisatake Kondo, Fumi Tashiro, Jun-ichi Miyazaki, Kunihiko Obata, Shinri Tamura, Yuchio Yanagawa

Biochimica et biophysica acta　Vol. 1628　No. 3　p. 156-68　2003/08/25　Research paper (scientific journal)

Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis

T Tsutsui, H Koide, H Fukahori, K Isoda, S Higashiyama, Maeda, I, F Tashiro, E Yamato, J Miyazaki, J Yodoi, M Kawase, K Yagi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 307　No. 4　p. 765-770　2003/08　Research paper (scientific journal)

Structural and functional characterization of mouse glutamate decarboxylase 67 gene promoter

T Kobayashi, S Ebihara, K Ishii, T Kobayashi, M Nishijima, S Endo, A Takaku, H Sakagami, H Kondo, F Tashiro, J Miyazaki, K Obata, S Tamura, Y Yanagawa

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION　Vol. 1628　No. 3　p. 156-168　2003/08　Research paper (scientific journal)

Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar-Kyoto rats

N Higuchi, H Maruyama, T Kuroda, S Kameda, N Iino, H Kawachi, Y Nishikawa, H Hanawa, H Tahara, J Miyazaki, F Gejyo

GENE THERAPY　Vol. 10　No. 16　p. 1297-1310　2003/08　Research paper (scientific journal)

The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells

Y Gao, JI Miyazaki, GW Hart

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS　Vol. 415　No. 2　p. 155-163　2003/07　Research paper (scientific journal)

A novel cytomedical vehicle capable of protecting cells against complement

Y Yoshioka, R Suzuki, H Oka, N Okada, T Okamoto, T Yoshioka, Y Mukai, H Shibata, Y Tsutsumi, S Nakagawa, J Miyazaki, T Mayumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 305　No. 2　p. 353-358　2003/05　Research paper (scientific journal)

Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes

Y Oshima, C Shukunami, J Honda, K Nishida, F Tashiro, J Miyazaki, Y Hiraki, Y Tano

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　Vol. 44　No. 5　p. 1814-1823　2003/05　Research paper (scientific journal)

Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells

Y Moritoh, E Yamato, Y Yasui, S Miyazaki, J Miyazaki

DIABETES　Vol. 52　No. 5　p. 1163-1168　2003/05　Research paper (scientific journal)

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes

K Yamamoto, H Hashimoto, S Tomimoto, N Shintani, J Miyazaki, F Tashiro, H Aihara, T Nammo, M Li, K Yamagata, J Miyagawa, Y Matsuzawa, Y Kawabata, Y Fukuyama, K Koga, W Mori, K Tanaka, T Matsuda, A Baba

DIABETES　Vol. 52　No. 5　p. 1155-1162　2003/05　Research paper (scientific journal)

Sustained expression of Fc-fusion cytokine following in vivo electroporation and mouse strain differences in expression levels

JJ Jiang, E Yamato, J Miyazaki

JOURNAL OF BIOCHEMISTRY　Vol. 133　No. 4　p. 423-427　2003/04　Research paper (scientific journal)

IGF-I gene transfer by electroporation promotes regeneration in a muscle injury model

T Takahashi, K Ishida, K Itoh, Y Konishi, KI Yagyu, A Tominaga, JI Miyazaki, H Yamamoto

GENE THERAPY　Vol. 10　No. 8　p. 612-620　2003/04　Research paper (scientific journal)

Chondromodulin-Iに相同性を有する新規膜蛋白Tenomodulinの機能ドメインによる血管新生抑制

大島 佑介, 田代 文, 宮崎 純一, 宿南 知佐, 開 祐司, 西田 幸二, 田野 保雄

日本眼科学会雑誌　Vol. 107　No. 臨増　p. 331-331　2003/03

Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice

T Sakai, H Hisaeda, Y Nakano, MX Zhang, M Takashima, K Ishii, Y Maekawa, S Matsumoto, Y Nitta, J Miyazaki, S Yamamoto, K Himeno

VACCINE　Vol. 21　No. 13-14　p. 1432-1444　2003/03　Research paper (scientific journal)

Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice

A Nakamura, Y Mori, K Hagiwara, T Suzuki, T Sakakibara, T Kikuchi, T Igarashi, M Ebina, J Miyazaki, T Takai, T Nukiwa, T Nukiwa

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 197　No. 5　p. 669-674　2003/03　Research paper (scientific journal)

Inhibitory effect of the α1-antitrypsin Pittsburgh type-mutant (α1-PIM/R) on proinsulin processing in the regulated secretory pathway of the pancreatic β-cell line MIN6

Kumiko Ohkubo, Yuko Naito, Toshiyuki Fujiwara, Jun-Ichi Miyazaki, Yukio Ikehara, Junko Ono

Endocrine Journal　Vol. 50　No. 1　p. 9-20　2003/02　Research paper (scientific journal)

High-level expression of interleukin-4 following electroporation-mediated gene transfer accelerates Type 1 diabetes in NOD mice

Mayumi Horiki, Eiji Yamato, Shinsuke Noso, Hiroshi Ikegami, Toshio Ogihara, Jun-Ichi Miyazaki

Journal of Autoimmunity　Vol. 20　No. 2　p. 111-117　2003　Research paper (scientific journal)

β-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas.

Taniguchi H, Yamato E, Tashiro F, Ikegami H, Ogihara T, Miyazaki J-I

Gene Therapy　Vol. 10:15-23　2003/01　Research paper (scientific journal)

Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells.

Tateishi, S, Niwa, H, Miyazaki, J, Fujimoto, S, Inoue, H, Yamaizumi, M

Mol. Cell. Biol.　Vol. 23: 474-481　2003/01　Research paper (scientific journal)

Inhibitory effect for proinsulin processing and secretory pathway of the a1-antitrypsin Pittsburgh like-mutant (α1-PIM/R) in the pancreatic β-cell line MIN6.

Ohkubo, K, Naito, Y, Fujiwara, T, Miyazaki, J, Ikehara, Y, Ono, J

Diabetes　2002/12　Research paper (scientific journal)

High-level expression of viral interleukin-10 in cardiac allografts fails to prolong graft survival

O Adachi, E Yamato, S Kawamoto, M Yamamoto, H Tahara, K Tabayashi, JI Miyazaki

TRANSPLANTATION　Vol. 74　No. 11　p. 1603-1608　2002/12　Research paper (scientific journal)

Protective effect of 15-deoxy-delta12,14-prostaglandin J2 on cell death induced by nitric oxide in pancreatic beta cells

Yuki Ueno, Toshihiko Osawa, Jun-ichi Miyazaki, Koji Uchida

International Congress Series　Vol. 1245　No. C　p. 415-416　2002/11/01　Research paper (international conference proceedings)

Development of a Novel Cytomedical Treatment that can Protect Entrapped Cells from Host Humoral Immunity

Ryo Suzuki, Yasuo Yoshioka, Etsuko Kitano, Tatsunobu Yoshioka, Hiroaki Oka, Takayuki Okamoto, Naoki Okada, Yasuo Tsutsumi, Shinsaku Nakagawa, Jun-Ichi Miyazaki, Hajime Kitamura, Tadanori Mayumi

Cell Transplantation　Vol. 11　No. 8　p. 787-797　2002/11　Research paper (scientific journal)

GFP Expression in the Mammary Gland for Imaging of Mammary Tumor Cells in Transgenic Mice.

Ahmed, F, Wyckoff, J, Lin, E. Y, Wang, W, Wang, Y, Hennighausen, L, Miyazaki, J, Jones, J, Pollard, J. W, Condeelis, J. S, Segall, J. E

Cancer Res.　Vol. 62: 7166-7169　2002/11　Research paper (scientific journal)

In vivo gene transfer into muscle via electro-sonoporation

YI Yamashita, M Shimada, K Tachibana, N Harimoto, E Tsujita, K Shirabe, JI Miyazaki, K Sugimachi

HUMAN GENE THERAPY　Vol. 13　No. 17　p. 2079-2084　2002/11　Research paper (scientific journal)

Gene gun-mediated CTLA4Ig-gene transfer for modification of allogeneic cardiac grafts

Y Umeda, H Iwata, S Yoshikawa, Y Matsuno, T Marui, T Nitta, Y Idia, H Takagi, Y Mori, J Miyazaki, A Kosugi, H Hirose

TRANSPLANTATION PROCEEDINGS　Vol. 34　No. 7　p. 2622-2623　2002/11　Research paper (scientific journal)

Suppression of graft coronary arteriosclerosis by gene gun-mediated CTLA4-Ig gene transfer

Y Matsuno, H Iwata, S Yoshikawa, Y Umeda, Y Iida, H Takagi, Y Mori, J Miyazaki, A Kosugi, H Hirose

TRANSPLANTATION PROCEEDINGS　Vol. 34　No. 7　p. 2619-2621　2002/11　Research paper (scientific journal)

マウス小腸におけるMICA発現による胸腺外二重陽性(DP)上皮内リンパ球(IELs)クローンの拡大(Clonal expansion of extrathymic double-positive(DP)IELs by the expression of MICA in mouse small intestine)

Park Eun Jeong, Takahashi Ichiro, Groh Veronika, Spies Thomas, Obata Yuichi, Miyazaki Jun-ichi, Kiyono Hiroshi

日本免疫学会総会・学術集会記録　Vol. 32　p. 40-40　2002/10　Research paper (other academic)

Cyotomedical therapy for insulinopenic diabetes using microencapsulated pancreatic β cell lines

Ryo Suzuki, Naoki Okada, Hajime Miyamoto, Tatsunobu Yoshioka, Kayoko Sakamoto, Hiroaki Oka, Yasuo Tsutsumi, Shinsaku Nakagawa, Jun-ichi Miyazaki, Tadanori Mayumi

Life Sciences　Vol. 71　No. 15　p. 1717-1729　2002/08/30　Research paper (scientific journal)

Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols (vol 21, pg 3486, 2002)

M Takao, S Kanno, T Shiromoto, R Hasegawa, H Ide, S Ikeda, AH Sarker, S Seki, JZ Xing, XC Le, M Weinfeld, K Kobayashi, J Miyazaki, M Muijtjens, JHJ Hoeijmakers, G van der Horst, A Yasui

EMBO JOURNAL　Vol. 21　No. 16　p. 4391-4391　2002/08　Research paper (scientific journal)

IL-15-dependent activation-induced cell death-resistant Th1 type CD8αβ+NK1.1+ T cells for the development of small intestinal inflammation.

Ohta, N, Hiroi, T, Kweon, M.-N, Kinoshita, N, Jang, M. H, Mashimo, T, Miyazaki, J, Kiyono, H

J. Immunol.　Vol. 169: 460-468　2002/08　Research paper (scientific journal)

Polyethyleneimine/chitosan hexamer-mediated gene Transfection into intestinal epithelial cell cultured in serum-containing medium

Y Ouji, A Yoshida-Terakura, Y Hayashi, Maeda, I, M Kawase, E Yamato, JI Miyazaki, K Yagii

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 94　No. 1　p. 81-83　2002/07　Research paper (scientific journal)

Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression.

Kawahata, K, Misaki, Y, Yamauchi, M, Tsunekawa, S, Setoguchi, K, Miyazaki, J, Yamamoto, K

J Immunol.　Vol. 168: 4399-4405　2002/07　Research paper (scientific journal)

Peripheral tolerance to a nuclear autoantigen: dendritic cells expressing a nuclear autoantigen lead to persistent anergic state of CD4+ autoreactive T cells after proliferation.

Kawahata, K, Misaki, Y, Yamauchi, M, Tsunekawa, S, Setoguchi, K, Miyazaki, J, Yamamoto, K

J. Immunol.　Vol. 168: 1103-1112　2002/06　Research paper (scientific journal)

High-level expression of naked DNA delivered to rat liver via tail vein injection

H Maruyama, N Higuchi, Y Nishikawa, S Kameda, N Iino, JJ Kazama, N Takahashi, M Sugawa, H Hanawa, N Tada, J Miyazaki, F Gejyo

JOURNAL OF GENE MEDICINE　Vol. 4　No. 3　p. 333-341　2002/05　Research paper (scientific journal)

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

S Takashima, M Kitakaze, M Asakura, H Asanuma, S Sanada, F Tashiro, H Niwa, J Miyazaki, S Hirota, Y Kitamura, T Kitsukawa, H Fujisawa, M Klagsbrun, M Hori

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 99　No. 6　p. 3657-3662　2002/03　Research paper (scientific journal)

Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats

Hiroki Maruyama, Noboru Higuchi, Yuji Nishikawa, Hiroyuki Hirahara, Noriaki Iino, Shigemi Kameda, Hiroshi Kawachi, Eishin Yaoita, Fumitake Gejyo, Jun-Ichi Miyazaki

Human Gene Therapy　Vol. 13　No. 3　p. 455-468　2002/02/10　Research paper (scientific journal)

Metabolic consequence of long-term exposure of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity.

Katsumi Iizuka, Hiromu Nakajima, Mitsuyoshi Namba, Jun ichiro Miyagawa, Junichi Miyazaki, Toshiaki Hanafusa, Yuji Matsuzawa

Biochimica et biophysica acta　Vol. 1586　No. 1　p. 23-31　2002/01/02　Research paper (scientific journal)

Metabolic consequence of long-term exposure of pancreatic β cells to free fatty acid with special reference to glucose insensitivity

Katsumi Iizuka, Hiromu Nakajima, Mitsuyoshi Namba, Jun-ichiro Miyagawa, Junichi Miyazaki, Toshiaki Hanafusa, Yuji Matsuzawa

Biochimica et Biophysica Acta - Molecular Basis of Disease　Vol. 1586　No. 1　p. 23-31　2002/01/02　Research paper (scientific journal)

In vitro Cre/loxP system in cells from developing gonads: Investigation of the Sry promoter

Masanori Ito, Kou Yokouchi, Kunihiko Naito, Hitoshi Endo, Yoji Hakamata, Jun-Ichi Miyazaki, Hideaki Tojo

Development Growth and Differentiation　Vol. 44　No. 6　p. 549-557　2002　Research paper (scientific journal)

Gene tranfer of Fc-fusion cytokine by in vivo electroporation: Application to gene therapy for viral myocarditis

O. Adachi, A. Nakano, O. Sato, S. Kawamoto, H. Tahara, N. Toyoda, E. Yamato, A. Matsumori, K. Tabayashi, J. Miyazaki

Gene Therapy　Vol. 9　No. 9　p. 577-583　2002　Research paper (scientific journal)

Locally expressed CTLA4-Ig in a pancreatic beta-cell line suppresses accelerated graft rejection response induced by donor-specific transfusion

F. Kimura, M. Gotoh, T. Tanaka, Z. Luo, J. Miyazaki, T. Uede, M. Monden, M. Miyasaka

Diabetologia　Vol. 45　No. 6　p. 831-840　2002　Research paper (scientific journal)

Administration of plasmids expressing interleukin-4 and interleukin-10 causes BALB/c mice to induce a T helper 2-type response despite the expected T helper 1-type response with a low-dose infection of Leishmania major

Kazuo Yamakami, Shinkichi Akao, Takushi Tadakuma, Yoshio Nitta, Jyun-Ichi Miyazaki, Nobuyuki Yoshizawa

Immunology　Vol. 105　No. 4　p. 515-523　2002　Research paper (scientific journal)

Differentiation of embryonic stem cells is induced by GATA factors

Junji Fujikura, Eiji Yamato, Shigenobu Yonemura, Kiminori Hosoda, Shinji Masui, Kazuwa Nakao, Jun-Ichi Miyazaki, Hitoshi Niwa

Genes and Development　Vol. 16　No. 7　p. 784-789　2002　Research paper (scientific journal)

A convenient cancer vaccine therapy with in vivo transfer of interleukin 12 expression plasmid using gene gun technology after priming with irradiated carcinoma cells

Masa-aki Nishitani, Tohru Sakai, Kazunari Ishii, Manxin Zhang, Yoko Nakano, Yoshio Nitta, Jun-Ichi Miyazaki, Hiro-Omi Kanayama, Susumu Kagawa, Kunisuke Himeno

Cancer Gene Therapy　Vol. 9　No. 2　p. 156-163　2002　Research paper (scientific journal)

Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-Kinase 2 gene

H Takahashi, U Koshimizu, J Miyazaki, T Nakamura

DEVELOPMENTAL BIOLOGY　Vol. 241　No. 2　p. 259-272　2002/01　Research paper (scientific journal)

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells

Hitoshi Niwa, Shinji Masui, Ian Chambers, Austin G. Smith, Jun-Ichi Miyazaki

Molecular and Cellular Biology　Vol. 22　No. 5　p. 1526-1536　2002　Research paper (scientific journal)

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

S Hasegawa, T Sato, H Akazawa, H Okada, A Maeno, M Ito, Y Sugitani, H Shibata, J Miyazaki, M Katsuki, Y Yamauchi, K Yamamura, S Katamine, T Noda

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 99　No. 1　p. 297-302　2002/01　Research paper (scientific journal)

Electroporation-mediated tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L gene therapy for hepatocellular carcinoma

YI Yamashita, M Shimada, S Tanaka, M Okamamoto, JI Miyazaki, K Sugimachi

HUMAN GENE THERAPY　Vol. 13　No. 2　p. 275-286　2002/01　Research paper (scientific journal)

Intravenous delivery of naked plasmid DNA for in vivo cytokine expression

JJ Jiang, E Yamato, J Miyazaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 289　No. 5　p. 1088-1092　2001/12　Research paper (scientific journal)

Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation.

Watanabe, K, Nakazawa, M, Fuse, K, Hanawa, H, Kodama, M, Aizawa, Y, Ohnuki, Y, Gejyo, F, Maruyama, H, Miyazaki, J

Circulation　Vol. 104: 1098-1100　2001/11　Research paper (scientific journal)

Gene transfer into muscle by electroporation in vivo.

Miyazaki, J, Aihara, H

In Gene Therapy Protocols 2nd Ed., Morgan, J. R. ed. (Hamana Press, Totowa, New Jersey).　Vol. pp. 49-62　2001/10　Research paper (scientific journal)

IL-18-transgenic mice: In vivo evidence of a broad role for IL-18 in modulating immune function.

Hoshino, T, Kawase, Y, Okamoto, M, Yokota, K, Yoshino, K, Yamamura, K, Miyazaki, J, Young, H, A, Oizumi, K

J. Immunol.　Vol. 166: 7014-7018　p. 7014-7018　2001/10　Research paper (scientific journal)

A novel enhancer of insulinotropic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic -cells via a new cellular mechanism.

Itabashi, N, Okada, K, Muto, S, Fujita, N, Ohta, T, Miyazaki, J, Asano, Y, Saito, T

J. Pharmacol. and Exp. Ther.　Vol. 297: 953-960　2001/08　Research paper (scientific journal)

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

Yusuke Ohba, Koichi Ikuta, Atsuo Ogura, Junichiro Matsuda, Naoki Mochizuki, Kazuo Nagashima, Kazuo Kurokawa, Bruce J. Mayer, Kazushige Maki, Jun-Ichi Miyazaki, Michiyuki Matsuda

EMBO Journal　Vol. 20　No. 13　p. 3333-3341　2001/07/02　Research paper (scientific journal)

Electroporation-mediated interleukin-12 gene therapy for hepatocellular carcinoma in the mice model.

Yamashita, Y, Shimada, M, Hasegawa, H, Minagawa, R, Rikimaru, T, Hamatsu, T, Tanaka, S, Shirabe, K, Miyazaki, J, Sugimachi, K

Cancer Res.　Vol. 61　No. 3　p. 1005-1012　2001/07　Research paper (scientific journal)

Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2

Chikara Meno, Jun Takeuchi, Rui Sakuma, Kazuko Koshiba-Takeuchi, Sachiko Ohishi, Yukio Saijoh, Jun-Ichi Miyazaki, Peter Ten Dijke, Toshihiko Ogura, Hiroshi Hamada

Developmental Cell　Vol. 1　No. 1　p. 127-138　2001/07　Research paper (scientific journal)

Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1

Mitsuhiro Yamada, Toshikazu Takeshita, Shigeto Miura, Kazuko Murata, Yutaka Kimura, Naoto Ishii, Masato Nose, Hiroyuki Sakagami, Hisatake Kondo, Fumi Tashiro, Jun Ichi Miyazaki, Hidetada Sasaki, Kazuo Sugamura

Molecular and Cellular Biology　Vol. 21　No. 11　p. 3807-3819　2001/06　Research paper (scientific journal)

Resistance to fulminant hepatitis and carcinogenesis conferred by overexpression of retinoblastoma protein in mouse liver

T Ichihara, Y Komagata, XL Yang, T Uezato, K Enomoto, K Koyama, JI Miyazaki, T Sugiyama, N Miura

HEPATOLOGY　Vol. 33　No. 4　p. 948-955　2001/04　Research paper (scientific journal)

Impaired fertility in female mice lacking urinary trypsin inhibitor

H Sato, S Kajikawa, S Kuroda, Y Horisawa, N Nakamura, N Kaga, C Kakinuma, K Kato, H Morishita, H Niwa, J Miyazaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 281　No. 5　p. 1154-1160　2001/03　Research paper (scientific journal)

Purkinje cell-specific and inducible gene recombination system generated from C57BL/6 mouse ES cells

K Kitayama, M Abe, T Kakizaki, D Honma, R Natsume, M Fukaya, M Watanabe, J Miyazaki, M Mishina, K Sakimura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 281　No. 5　p. 1134-1140　2001/03　Research paper (scientific journal)

cDNA array hybridization reveals cardiac gene expression in acute ischemic murine hearts

M Kitakaze, M Asakura, Y Sakata, H Asanuma, S Sanada, T Kuzuya, J Miyazaki, S Takashima, M Hori

CARDIOVASCULAR DRUGS AND THERAPY　Vol. 15　No. 2　p. 125-130　2001/03　Research paper (scientific journal)

Effects of locally expressed CTLA4-Ig in a pancreatic beta cell line on the accelerated graft rejection response induced by DST

F Kimura, M Gotoh, T Tanaka, Z Luo, J Miyazaki, M Monden, T Uede, M Miyasaka

TRANSPLANTATION PROCEEDINGS　Vol. 33　No. 1-2　p. 552-552　2001/02　Research paper (scientific journal)

Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo

YY Kisanuki, RE Hammer, J Miyazaki, SC Williams, JA Richardson, M Yanagisawa

DEVELOPMENTAL BIOLOGY　Vol. 230　No. 2　p. 230-242　2001/02　Research paper (scientific journal)

In vitro differentiation of ES cells and its application to cell therapy

J. I. Miyazaki, H. Niwa

Biotherapy　Vol. 15　No. 2　p. 111-118　2001　Research paper (scientific journal)

Incorporation of sulfonylurea into sugar-carrying polymers and their effects on insulin secretion from MIN6 cells in a solution state

KH Park, M Goto, JI Miyazaki, CS Cho, T Akaike

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION　Vol. 12　No. 8　p. 911-920　2001　Research paper (scientific journal)

Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in t cells

M. Narimatsu, H. Maeda, S. Itoh, T. Atsumi, T. Ohtani, K. Nishida, M. Itoh, D. Kamimura, S. J. Park, K. Mizuno, J. I. Miyazaki, M. Hibi, K. Ishihara, K. Nakajima, T. Hirano

Molecular and Cellular Biology　Vol. 21　No. 19　p. 6615-6625　2001　Research paper (scientific journal)

Cytokine gene therapy for myocarditis by in vivo electroporation

A. Nakano, A. Matsumori, S. Kawamoto, H. Tahara, E. Yamato, S. Sasayama, J. I. Miyazaki

Human Gene Therapy　Vol. 12　No. 10　p. 1289-1297　2001　Research paper (scientific journal)

Usefulness of double gene construct for rapid identification of transgenic mice exhibiting tissue-specific gene expression

Masahiro Sato, Toshiteru Watanabe, Akiko Oshida, Ayako Nagashima, Jun-Ichi Miyazaki, Minoru Kimura

Molecular Reproduction and Development　Vol. 60　No. 4　p. 446-456　2001　Research paper (scientific journal)

Regulation of cell proliferation using tissue engineering in MIN6 cells

N Kinoshita, Y Echigo, S Shinohara, YJ Gu, J Miyazaki, K Inoue, M Imamura

CELL TRANSPLANTATION　Vol. 10　No. 4-5　p. 473-477　2001　Research paper (scientific journal)

Suppression of Th1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10

Shunsuke Kawamoto, Yoshio Nitta, Fumi Tashiro, Atsushi Nakano, Eiji Yamato, Hideaki Tahara, Koichi Tabayashi, Jun-ichi Miyazaki

International Immunology　Vol. 13　No. 5　p. 685-694　2001　Research paper (scientific journal)

Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats

H. Maruyama, K. Ataka, F. Gejyo, N. Higuchi, Y. Ito, H. Hirahara, I. Imazeki, M. Hirata, F. Ichikawa, T. Neichi, H. Kikuchi, M. Sugawa, J. Miyazaki

Gene Therapy　Vol. 8　No. 6　p. 461-468　2001　Research paper (scientific journal)

Nonviral gene gun-mediated CTLA4-Ig gene transfer for modification of donor organs

Y. Umeda, H. Hirose, S. Yoshikawa, Y. Matsuno, Y. Fukumoto, T. Nitta, Y. Iida, H. Takagi, Y. Mori, D. Liddicoat, J. Miyazaki, A. Kosugi, H. Iwata

Transplantation Proceedings　Vol. 33　No. 1-2　p. 243-245　2001　Research paper (scientific journal)

Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival

Shigetoshi Sano, Yousuke Takahama, Takehiko Sugawara, Hiroshi Kosaka, Satoshi Itami, Kunihiko Yoshikawa, Jun-ichi Miyazaki, Willem Van Ewijk, Junji Takeda

Immunity　Vol. 15　No. 2　p. 261-273　2001　Research paper (scientific journal)

Skin-targeted gene transfer using in vivo electroporation

H. Maruyama, K. Ataka, N. Higuchi, F. Sakamoto, F. Gejyo, J. Miyazaki

Gene Therapy　Vol. 8　No. 23　p. 1808-1812　2001　Research paper (scientific journal)

A single intradermal administration of soluble leishmanial antigen and plasmid expressing interleukin-12 protects BALB/c mice from Leishmania major infection

Kazuo Yamakami, Shinkichi Akao, Masaki Sato, Yoshio Nitta, Jyun-Ichi Miyazaki, Takushi Tadakuma

Parasitology International　Vol. 50　No. 2　p. 81-91　2001　Research paper (scientific journal)

IL-12 plays a pathologic role at the inflammatory loci in the development of diabetes in NOD mice

Yoshio Nitta, Shunsuke Kawamoto, Fumi Tashiro, Hiroyuki Aihara, Takayuki Yoshimoto, Hideo Nariuchi, Koichi Tabayashi, Jun-Ichi Miyazaki

Journal of Autoimmunity　Vol. 16　No. 2　p. 97-104　2001　Research paper (scientific journal)

Enhanced green fluorescent protein as a useful tag for rapid identification of homozygous transgenic mice

Masahiro Sato, Toshiteru Watanabe, Akiko Oshida, Ayako Nagashima, Jun-ichi Miyazaki, Minoru Kimura

Biomolecular Engineering　Vol. 17　No. 3　p. 83-85　2001　Research paper (scientific journal)

Human LT-alpha-mediated resistance to autoimmune diabetes is induced in NOD, but not NOD-scid, mice and abrogated by IL-12

S Miyaguchi, J Satoh, K Takahashi, Y Sakata, T Nakazawa, J Miyazaki, T Toyota

CLINICAL IMMUNOLOGY　Vol. 98　No. 1　p. 119-124　2001/01　Research paper (scientific journal)

Oxidative stess and pancreatic β-cell destruction in insulin-dependent diabetes mellitus.

Hotta, M, Yamato, E, Miyazaki, J

In Antioxidants in Diabetes Management, L. Packer, P. Rosen, H. J. Tritschler, G. L. King & A. Azzi Eds.　Vol. pp265-274　2000/07

Spermatocyte-specific gene excision by targeted expression of Cre recombinase

Hiroshi Ando, Yoshiya Haruna, Jun-Ichi Miyazaki, Masaru Okabe, Yoshinobu Nakanishi

Biochemical and Biophysical Research Communications　Vol. 272　No. 1　p. 125-128　2000/05/27　Research paper (scientific journal)

New approach to cell lineage analysis in mammals using the Cre-loxP system

M Sato, Y Yasuoka, H Kodama, T Watanabe, J Miyazaki, M Kimura

MOLECULAR REPRODUCTION AND DEVELOPMENT　Vol. 56　No. 1　p. 34-44　2000/05　Research paper (scientific journal)

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

H Niwa, J Miyazaki, AG Smith

NATURE GENETICS　Vol. 24　No. 4　p. 372-376　2000/04　Research paper (scientific journal)

A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination

Shunsuke Kawamoto, Hitoshi Niwa, Fumi Tashiro, Shigetoshi Sano, Gen Kondoh, Junji Takeda, Koichi Tabayashi, Jun-Ichi Miyazaki

FEBS Letters　Vol. 470　No. 3　p. 263-268　2000/03/31　Research paper (scientific journal)

Dual renin gene targeting by Cre-mediated interchromosomal recombination

Taiji Matsusaka, Valentina Kon, Junji Takaya, Hideyuki Katori, Xian-Mei Chen, Jun-Ichi Miyazaki, Toshio Homma, Agnes Fogo, Iekuni Ichikawa

Genomics　Vol. 64　No. 2　p. 127-131　2000/03/01　Research paper (scientific journal)

Continuous erythropoietin delivery by muscle-targeted gene transfer using in vivo electroporation

Hiroki Maruyama, Makoto Sugawa, Yoshiyuki Moriguchi, Ikuo Imazeki, Yasuko Ishikawa, Ken Ataka, Susumu Hasegawa, Yumi Ito, Noboru Higuchi, Junichiro J. Kazama, Fumitake Gejyo, Jun-Ichi Miyazaki

Human Gene Therapy　Vol. 11　No. 3　p. 429-437　2000/02/10　Research paper (scientific journal)

Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination

Shin Hisahara, Takashi Araki, Fumihiro Sugiyama, Ken-Ichi Yagami, Misao Suzuki, Kuniya Abe, Ken-Ichi Yamamura, Jun-Ichi Miyazaki, Takashi Momoi, Takao Saruta, Claude C. A. Bernard, Hideyuki Okano, Masayuki Miura

EMBO Journal　Vol. 19　No. 3　p. 341-348　2000/02/01　Research paper (scientific journal)

Enhanced effect of sulfonylurea (SU) in copolymer comprising a sugar moiety and SU derivative as double ligands on insulin secretion from MIN6 cells

KH Park, M Goto, R Takei, A Maruyama, K Kobayashi, J Miyazaki, CS Cho, T Akaike

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION　Vol. 11　No. 9　p. 903-913　2000　Research paper (scientific journal)

Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines

Kohtaro Minami, Hideki Yano, Takashi Miki, Kazuaki Nagashima, Chang-Zheng Wang, Hiroko Tanaka, Jun-Ichi Miyazaki, Susumu Seino

American Journal of Physiology - Endocrinology and Metabolism　Vol. 279　No. 4　p. E773-E781　2000　Research paper (scientific journal)

Structure of the mouse glutamate decarboxylase 65 gene and its promoter: Preferential expression of its promoter in the GABAergic neurons of transgenic mice

Kimitoshi Makinae, Takashi Kobayashi, Takayasu Kobayashi, Hideichi Shinkawa, Hiroyuki Sakagami, Hisatake Kondo, Fumi Tashiro, Jun-Ichi Miyazaki, Kunihiko Obata, Shinri Tamura, Yuchio Yanagawa

Journal of Neurochemistry　Vol. 75　No. 4　p. 1429-1437　2000　Research paper (scientific journal)

IL-12-encoding plasmid has a beneficial effect on spontaneous autoimmune disease in MRL/MP-lpr/lpr mice

Eri Hagiwara, Tadanobu Okubo, Ichiro Aoki, Shigeru Ohno, Takashi Tsuji, Atsushi Ihata, Atsuhisa Ueda, Akira Shirai, Kenji Okuda, Jun-Ichi Miyazaki, Yoshiaki Ishigatsubo

Cytokine　Vol. 12　No. 7　p. 1035-1041　2000　Research paper (scientific journal)

Cre-loxP-mediated bax gene activation reduces growth rate and increases sensitivity to chemotherapeutic agents in human gastric cancer cells

Koga Komatsu, Susumu Suzuki, Tooru Shimosegawa, Jun-Ichi Miyazaki, Takayoshi Toyota

Cancer Gene Therapy　Vol. 7　No. 6　p. 885-892　2000　Research paper (scientific journal)

Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice

T. Sakai, H. Hisaeda, Y. Nakano, H. Ishikawa, Y. Maekawa, K. Ishii, Y. Nitta, J. Miyazaki, K. Himeno

Immunology　Vol. 99　No. 4　p. 615-624　2000　Research paper (scientific journal)

Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic beta-cell line

K. Iizuka, H. Nakajima, A. Ono, K. Okita, J. I. Miyazaki, J. I. Miyagawa, M. Namba, T. Hanafusa, Y. Matsuzawa

Journal of Endocrinology　Vol. 164　No. 3　p. 307-314　2000　Research paper (scientific journal)

The T3b gene promoter directs intestinal epithelial cell-specific expression in transgenic mice

Hiroyuki Aihara, Nobuo Hiwatashi, Shinji Kumagai, Yuhichi Obata, Tooru Shimosegawa, Takayoshi Toyota, Jun-Ichi Miyazaki

FEBS Letters　Vol. 463　No. 1-2　p. 185-188　1999/12/10　Research paper (scientific journal)

Structure/function studies of hepatocyte nuclear factor-1α, a diabetes-associated transcription factor

Qin Yang, Kazuya Yamagata, Koji Yamamoto, Jun Ichiro Miyagawa, Jun Takeda, Naoko Iwasaki, Hiromi Iwahashi, Issei Yoshiuchi, Mitsuyoshi Namba, Jun Ichi Miyazaki, Toshiaki Hanafusa, Yuji Matsuzawa

Biochemical and Biophysical Research Communications　Vol. 266　No. 1　p. 196-202　1999/12/09　Research paper (scientific journal)

Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice.

Miyawaki, K, Yamada, Y, Yano, H, Niwa, H, Ban, N, Ihara, Y, Kubota, A, Fujimoto, S, Kajikawa, M, Kuroe, A, Tsuda, K, Hashimoto, H, Yamashita, T, Jomori, T, Tashiro, F, Miyazaki, J, Seino, Y

Proc. Natl. Acad. Sci. USA.　1999/11　Research paper (scientific journal)

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

Martha Hotz Vitaterna, Christopher P. Selby, Takeshi Todo, Hitoshi Niwa, Carol Thompson, Ethan M. Fruechte, Kenichi Hitomi, Randy J. Thresher, Tomoko Ishikawa, Junichi Miyazaki, Joseph S. Takahashi, Aziz Sancar

Proceedings of the National Academy of Sciences of the United States of America　Vol. 96　No. 21　p. 12114-12119　1999/10/12　Research paper (scientific journal)

Cerebellar granule cell-specific and inducible expression of Crerecombinase in the mouse.

Tsujita, M, Mori, H, Watanabe, M, Suzuki, M, Miyazaki, J, Mishina, M

J. Neuroscience　1999/10　Research paper (scientific journal)

Interleukin-12 p40 transgenic mice.

Yoshimoto, T, Yoneto, T, Wang, C.-R, Yasuda, T, Matsuzawa, A, Nitta, Y, Miyazaki, J, Waki, S, Nariuchi, H

I. Nath, N. K. Ganguly & K. V. S. Rao Eds. (Monduzzi Editore, Bologna, Italy)　1999/07　Research paper (scientific journal)

Enrichment and efficient screening of ES cells containing a targeted mutation: The use of DT-A gene with the polyadenylation signal as a negative selection maker

Yuchio Yanagawa, Takashi Kobayashi, Motoko Ohnishi, Takayasu Kobayashi, Shinri Tamura, Teruhisa Tsuzuki, Makoto Sanbo, Takeshi Yagi, Fumi Tashiro, Jun-ichi Miyazaki

Transgenic Research　Vol. 8　No. 3　p. 215-221　1999/06　Research paper (scientific journal)

Constructing adenoviral vectors by using the circular form of the adenoviral genome cloned in a cosmid and the Cre-loxP recombination system.

Tashiro, F, Niwa, H, Miyazaki, J

Human Gene Ther.　1999/06　Research paper (scientific journal)

MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube.

Saga, Y, Miyagawa-Tomita, S, Takagi, A, Kitajima, S, Miyazaki J, Inoue, T

Development　1999/06　Research paper (scientific journal)

Promoter/enhancer cassettes for keratinocyte gene therapy

D Sawamura, XM Meng, S Ina, H Nakano, K Tamai, K Nomura, K Hanada, JI Miyazaki, Hashimoto, I

JOURNAL OF INVESTIGATIVE DERMATOLOGY　Vol. 112　No. 5　p. 828-830　1999/05　Research paper (scientific journal)

Three new mutations in the hepatocyte nuclear factor-1 alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization

Yoshiuchi, I, K Yamagata, Q Yang, H Iwahashi, K Okita, K Yamamoto, T Oue, A Imagawa, T Hamaguchi, T Yamasaki, Y Horikawa, T Satoh, H Nakajima, J Miyazaki, S Higashiyama, J Miyagawa, M Namba, T Hanafusa, Y Matsuzawa

DIABETOLOGIA　Vol. 42　No. 5　p. 621-626　1999/05　Research paper (scientific journal)

Altered expression level of a systemic nuclear autoantigen determines the fate of immune response to self.

Kawahata, K, Misaki, Y, Komagata, Y, Setoguchi, K, Tsunekawa, S, Yoshikawa, Y, Miyazaki, J, Yamamoto, K

J. Immunol.　Vol. 162　No. 11　p. 6482-6491　1999/04　Research paper (scientific journal)

抗酸化ストレスタンパク質を膵ベータ細胞に過剰発現するトランスジェニックマウスにおける１型糖尿病発症の抑制

堀田瑞夫, 田代 文, 池上博司, 丹羽仁史, 倭 英司, 淀井淳司, 荻原俊男, 宮崎純一

分子糖尿病学　Vol. 10:1-5　1999/03

DNA immunization with Plasmodium falciparum serine repeat antigen: Regulation of humoral immune response by coinoculation of cytokine expression plasmid

Tohru Sakai, Toshihiro Horii, Hajime Hisaeda, Manxin Zhang, Kazunari Ishii, Yoko Nakano, Yoichi Maekawa, Keisuke Izumi, Yoshio Nitta, Jun-ichi Miyazaki, Kunisuke Himeno

Parasitology International　Vol. 48　No. 1　p. 27-33　1999/03/01　Research paper (scientific journal)

Administration of an IL-12-encoding DNA plasmid prevents the development of chronic graft-versus-host disease (GVHD).

Okubo, T, Hagiwara, E, Ohno, S, Tsuji, T, Ihata, A, Ueda, A, Shirai, A, Aoki, I, Okuda, K, Miyazaki, Ishigatsubo, Y

J. Immunol.　1999/03　Research paper (scientific journal)

Regulation of GABAergic cell-specific gene transcription

Y Yanagawa, T Kobayashi, K Ishii, H Sakagami, H Kondo, F Tashiro, JI Miyazaki, S Tamura

NEURAL DEVELOPMENT-BOOK　Vol. 2　p. 435-439　1999　Research paper (international conference proceedings)

Cre-loxP system confers cell lineage-specific expression of a reporter gene in murine preimplantation development

Masahiro Sato, Yukiko Yasuoka, Hisako Kodama, Toshiteru Watanabe, Jun-Ichi Miyazaki, Minoru Kimura

Journal of Reproduction and Development　Vol. 45　No. 6　p. 411-417　1999　Research paper (scientific journal)

Decreased food intake and body weight in pancreatic polypeptide- overexpressing mice

N. Ueno, A. Inui, M. Iwamoto, T. Kaga, A. Asakawa, M. Okita, M. Fujimiya, Y. Nakajima, Y. Ohmoto, M. Ohnaka, Y. Nakaya, J. I. Miyazaki, M. Kasuga

Gastroenterology　Vol. 117　No. 6　p. 1427-1432　1999　Research paper (scientific journal)

Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic β cells

Nobuko Ishizuka, Kazuo Yagui, Yoshiharu Tokuyama, Katsumi Yamada, Yoshifumi Suzuki, Jun-Ichi Miyazaki, Naotake Hashimoto, Hideichi Makino, Yasushi Saito, Azuma Kanatsuka

Metabolism: Clinical and Experimental　Vol. 48　No. 12　p. 1485-1492　1999　Research paper (scientific journal)

Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of amyloid-resistant apolipoprotein A-II

Takuya Chiba, Kumiko Kogishi, Jing Wang, Cher Xia, Takatoshi Matsushita, Jun-Ichi Miyazaki, Izumu Saito, Masanori Hosokawa, Keiichi Higuchi

American Journal of Pathology　Vol. 155　No. 4　p. 1319-1326　1999　Research paper (scientific journal)

Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: A possible role of Pax4 as a transcriptional repressor in the pancreas

Yoshio Fujitani, Yoshitaka Kajimoto, Tetsuyuki Yasuda, Taka-Aki Matsuoka, Hideaki Kaneto, Yutaka Umayahara, Noriko Fujita, Hirotaka Watada, Jun-Ichi Miyazaki, Yoshimitsu Yamasaki, Masatsugu Hori

Molecular and Cellular Biology　Vol. 19　No. 12　p. 8281-8291　1999　Research paper (scientific journal)

Accumulation of murine amyloidβ42 in a gene-dosage-dependent manner in PS1 'knock-in' mice

Y. Nakano, G. Kondoh, T. Kudo, K. Imaizumi, M. Kato, J. I. Miyazaki, M. Tohyama, J. Takeda, M. Takeda

European Journal of Neuroscience　Vol. 11　No. 7　p. 2577-2581　1999　Research paper (scientific journal)

Introduction of human CD40 gene with immunoglobulin enhancer and promoter creates mice with a population of human CD40(+) early B lineage cells in the bone marrow

S Inui, A Sakata, K Maeda, F Tashiro, JI Miyazaki, N Sakaguchi

TRANSGENICS　Vol. 2　No. 4　p. 347-356　1999　Research paper (scientific journal)

Pancreatic β cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes.

Hotta, M, Tashiro, F, Ikegami, H, Niwa, H, Ogihara, T, Yodoi, J, Miyazaki, J

Vol. 188　No. 8　p. 1445-1451　1998/12　Research paper (scientific journal)

Membrane immunoisolation of a diffusion chamber for a bioartificial pancreas.

Ohgawara, H, Hirotani, S, Miyazaki, J, Teraoka, S

Artif. Organs　1998/11　Research paper (scientific journal)

A composite CMV-IE enhancer/β-actin promoter is ubiquitously expressed in mouse cutaneous epithelium

Janet A. Sawicki, Rebecca J. Morris, Bob Monks, Katsunaga Sakai, Jun-Ichi Miyazaki

Experimental Cell Research　Vol. 244　No. 1　p. 367-369　1998/10/10　Research paper (scientific journal)

Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and Streptozotocin-induced diabetes

M Hotta, F Tashiro, H Ikegami, H Niwa, T Ogihara, J Yodoi, J Miyazaki

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 188　No. 8　p. 1445-1451　1998/10　Research paper (scientific journal)

Systemic delivery of IL-10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice.

Nitta, Y, Tashiro, F, Tokui, M, Shimada, A, Takei, I, Tabayashi, K, Miyazaki, J

Human Gene Ther.　1998/10　Research paper (scientific journal)

Defective insulin secretion and enhanced insulin action in K-ATP channel-deficient mice

T Miki, K Nagashima, F Tashiro, K Kotake, H Yoshitomi, A Tamamoto, T Gonoi, T Iwanaga, J Miyazaki, S Seino

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 95　No. 18　p. 10402-10406　1998/09　Research paper (scientific journal)

Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-β1.

Moritani, M, Yoshimoto, K, Wong, S. F, Tanaka, C, Yamaoka, T, Sano, T, Komagata, Y, Miyazaki , J, Kikutani, H, Itakura, M

Vol. 102　No. 3　p. 499-506　1998/09　Research paper (scientific journal)

Membrane immunoisolation of a diffusion chamber for a bioartificial pancreas

H Ohgawara, S Hirotani, J Miyazaki, S Teraoka

ARTIFICIAL ORGANS　Vol. 22　No. 9　p. 788-794　1998/09　Research paper (scientific journal)

Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic β cell line

Cyril Benes, Marie Paule Roisin, Huynh Van Tan, Claudine Creuzet, Jun-Ichi Miyazaki, Remi Fagard

Journal of Biological Chemistry　Vol. 273　No. 25　p. 15507-15513　1998/06/19　Research paper (scientific journal)

Simultaneous analysis of membrane potential and calcium mobilization in a pancreatic ß-cell line MIN6 by use of a double-probe imaging microscope-system

Koichiro Ozawa, Yasufumi Fukano, Tsuyoshi Azuma, Yasuyo Masumoto, Hiroko Hayashi, Atsushi Tamura, Jun-Ich Miyazaki, Tsutomu Masujima

Analytica Chimica Acta　Vol. 365　No. 1-3　p. 3-7　1998/06/05　Research paper (scientific journal)

ｋｎｏｃｋｏｕｔ ｍｏｕｓｅ

相原裕之, 宮崎純一

分子呼吸器学　Vol. 2:439-440　1998/06

Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor

Satoshi Ishii, Tomoyuki Kuwaki, Takahide Nagase, Kazushige Maki, Fumi Tashiro, Shinji Sunaga, Wei-Hua Cao, Kazuhiko Kume, Yoshinosuke Fukuchi, Koichi Ikuta, Jun-Ichi Miyazaki, Mamoru Kumada, Takao Shimizu

Journal of Experimental Medicine　Vol. 187　No. 11　p. 1779-1788　1998/06/01　Research paper (scientific journal)

ＤＮＡワクチンとその免疫制御への応用

徳井幹也, 武井 泉, 宮崎純一

臨床免疫　Vol. 30:370-376　1998/04

A T cell activation antigen, Ly6C, induced on CD4+ Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses.

Yamanouchi, S, Kuwahara, K, Sakata, A, Ezaki, T, Matsuoka, S, Miyazaki, J, Hirose, S, Tamura, T, Nariuchi, H, Sakaguchi, N

1998/04　Research paper (scientific journal)

Reduced T helper1 responses in IL-12 p40 transgenic mice.

Yoshimoto, T, Wang, C.-R, Yoneto, T, Waki, S, Sunaga, S, Komagata, Y, Mitsuyama, M, Miyazaki, J, Nariuchi, H

J. Immunol.　1998/02　Research paper (scientific journal)

22.Interleukin-10発現プラスミドDNA筋注法による自己免疫性糖尿病モデルマウス (NODマウス) の発症抑制

新田 能郎, 田代 文, 宮崎 純一

日本疾患モデル学会記録　Vol. 14　p. 44-44　1998

Response of human insulinoma cells to extracellular calcium is different from normal B cells

Masayuki Kato, Ryuichiro Doi, Masayuki Imamura, Noriyuki Okada, Yutaka Shimada, Ryo Hosotani, Jun-Ichi Miyazaki

Digestive Diseases and Sciences　Vol. 43　No. 11　p. 2429-2438　1998　Research paper (scientific journal)

Gene transfer into muscle by electroporation in vivo

Hiroyuki Aihara, Jun-Ichi Miyazaki

Nature Biotechnology　Vol. 16　No. 9　p. 867-870　1998　Research paper (scientific journal)

Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1α is dominant negative

Kazuya Yamagata, Qin Yang, Koji Yamamoto, Hiromi Iwahashi, Jun Ichiro Miyagawa, Kohei Okita, Issei Yoshiuchi, Jun Ichi Miyazaki, Tamio Noguchi, Hiromu Nakajima, Mitsuyoshi Namba, Toshiaki Hanafusa, Ynji Matsuzawa

Diabetes　Vol. 47　No. 8　p. 1231-1235　1998　Research paper (scientific journal)

Creation and characterization of a mitochondrial DNA-depleted pancreatic β-cell line: Impaired insulin secretion induced by glucose, leucine, and sulfonylureas

Kaku Tsuruzoe, Eiichi Araki, Noboru Furukawa, Tetsuya Shirotani, Kazuya Matsumoto, Kengo Kaneko, Hiroyuki Motoshima, Kazuaki Yoshizato, Atsuhisa Shirakami, Hideki Kishikawa, Jun-Ichi Miyazaki, Motoaki Shichiri

Diabetes　Vol. 47　No. 4　p. 621-631　1998　Research paper (scientific journal)

Repetitive mitochondrial Ca2+ signals synchronize with cytosolic Ca2+ oscillations in the pancreatic beta-cell line, MIN6

M. Nakazaki, H. Ishihara, M. Kakei, K. Inukai, T. Asano, J. I. Miyazaki, H. Tanaka, M. Kikuchi, T. Yada, Y. Oka

Diabetologia　Vol. 41　No. 3　p. 279-286　1998　Research paper (scientific journal)

New approach by tissue engineering for extended selective transplantation with a pancreatic B-cell line (MIN6)

H. Hayashi, K. Inoue, S. Shinohara, Y. J. Gu, H. Setoyama, Y. Kawakami, T. Yamasaki, W. X. Cui, N. Kinoshita, M. Imamura, H. Iwata, Y. Ikada, J. Miyazaki

Transplantation Proceedings　Vol. 30　No. 1　p. 83-85　1998　Research paper (international conference proceedings)

Abnormalities of pancreatic islets by targeted expression of a dominant-negative K-ATP channel

T Miki, F Tashiro, T Iwanaga, K Nagashima, H Yoshitomi, H Aihara, Y Nitta, T Gonoi, N Inagaki, J Miyazaki, S Seino

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 94　No. 22　p. 11969-11973　1997/10　Research paper (scientific journal)

トランスジェニック技術

宮崎純一

ｍｅｄｉｃｉｎａ　Vol. 34:2119-2123　1997/09

Complete rescue of lethal albino c(14CoS) mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway

F Endo, S Kubo, H Awata, K Kiwaki, H Katoh, Y Kanegae, Saito, I, J Miyazaki, T Yamamoto, C Jakobs, S Hattori, Matsuda, I

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 39　p. 24426-24432　1997/09　Research paper (scientific journal)

Subcutaneous xenotransplantation of hybrid artificial pancreas encapsulating pancreatic B cell line (MIN6): Functional and histological study

Y Kawakami, K Inoue, H Hayashi, WJ Wang, H Setoyama, YJ Gu, M Imamura, H Iwata, Y Ikada, M Nozawa, JI Miyazaki

CELL TRANSPLANTATION　Vol. 6　No. 5　p. 541-545　1997/09　Research paper (scientific journal)

Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.

Kajimoto, Y, Watada, H, Matsuoka, T, Kaneto, H, Fujitani, Y, Miyazaki, J, Yamasaki, Y

J. Clin. Invest.　1997/09　Research paper (scientific journal)

Expression of human islet amyloid polypeptide amylin impairs insulin secretion in mouse pancreatic beta cells

T Tokuyama, K Yagui, T Yamaguchi, CI Huang, N Kuramoto, F Shimada, J Miyazaki, H Horie, Y Saito, H Makino, A Kanatsuka

METABOLISM-CLINICAL AND EXPERIMENTAL　Vol. 46　No. 9　p. 1044-1051　1997/09　Research paper (scientific journal)

A transgenic mouse line that retains Cre recomblinse activity in mature oocytes irrespective of the cre transgene transmission.

Sakai, K, Miyazaki, J

Biochem. Biophys. Res. Commun. 237:　1997/09　Research paper (scientific journal)

Intranasal immunization of a DNA vaccine with IL-12-and granulocyte-macrophage colony-stimulating factor(GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.

Okada, E, Sasaki, S, Ishii, N, Aoki, I, Yasuda, T, Nishioka, K, Fukushima, J, Miyazaki, J, Wahren, B, Okuda, K

J. Immunol.　1997/08　Research paper (scientific journal)

個体への遺伝子導入法ートランスジェニックマウス

相原裕之, 宮崎純一

現代医療　Vol. 29:1679-1683　1997/07

Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the TH1 cytokine mRNA in grafts

T Takeuchi, T Ueki, S Sunaga, K Ikuta, Y Sasaki, BX Li, N Moriyama, J Miyazaki, K Kawabe

TRANSPLANTATION　Vol. 64　No. 1　p. 152-157　1997/07　Research paper (scientific journal)

Developmentally ordered V-J recombination in mouse T cell receptor γ locus is not perturbed by targeted deletion of the Vγ4 gene.

Sunaga, S, Maki, K, Komagata, Y, Miyazaki, J, Ikuta, K

1997/07　Research paper (scientific journal)

Enhancement of cell-mediated immunity against HIV-1 induced by coinoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12.

Tsuji, T, Hamajima, K, Fukushima, J, Xin, K.-Q, Ishii, N, Aoki, I, Ishigatsubo, Y, Tani, K, Kawamoto, S, Nitta, Y, Miyazaki, J, Koff, W. C, Okubo, T, Okuda, K

J. Immunol.　1997/06　Research paper (scientific journal)

糖尿病自然発症モデル（ＮＯＤ）マウス

堀田瑞夫, 池上博司, 宮崎純一

最新医学社　1997/06

Intramuscular injection of expression plasmid DNA is an effective means of long-term systemic delivery of interleukin-5.

Tokui, M, Takei, I, Tashiro, F, Shimada, A, Kasuga, A, Ishii, T, Ishii, M, Takatsu, K, Saruta, T, Miyazaki, J

Biochem. Biophys. Res. Commun.　1997/05　Research paper (scientific journal)

内分泌・代謝疾患のモデル動物

堀田瑞夫, 宮崎純一

最新内科学体系、プログレスシリーズ「内分泌・代謝疾患」　Vol. 21-29　1997/04

Efficient removal of loxP-Flanked DNA sequences in a gene-targeted locus by transient expression of Cre recombinase in fertilized eggs

S Sunaga, K Maki, Y Komagata, K Ikuta, J Miyazaki

MOLECULAR REPRODUCTION AND DEVELOPMENT　Vol. 46　No. 2　p. 109-113　1997/02　Research paper (scientific journal)

Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor

Satoshi Ishii, Takahide Nagase, Fumi Tashiro, Koichi Ikuta, Sayuri Sato, Iwao Waga, Kazuhiko Kume, Jun-Ichi Miyazaki, Takao Shimizu

EMBO Journal　Vol. 16　No. 1　p. 133-142　1997/01/02　Research paper (scientific journal)

Heterogeneity of gamma delta T cells in the mouse liver

Y Kodaira, K Ikuta, S Tanaka, JI Miyazaki, K Yokomuro

CELLS OF THE HEPATIC SINUSOID, VOL 6　p. 460-462　1997　Research paper (international conference proceedings)

Suppression of pulmonary metastasis in murine B16 melanoma cells by transfection of a sialidase cDNA

Satoru Tokuyama, Setsuko Moriya, Shun'ichiro Taniguchi, Akira Yasui, Jun-Ichi Miyazaki, Seiichi Orikasa, Taeko Miyagi

International Journal of Cancer　Vol. 73　No. 3　p. 410-415　1997　Research paper (scientific journal)

Encapsulation of mammalian cells into synthetic polymer membranes using least toxic solvents

N Morikawa, H Iwata, S Matsuda, J Miyazaki, Y Ikada

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION　Vol. 8　No. 8　p. 575-586　1997　Research paper (scientific journal)

Role of cytosolic phospholipase A2 in allergic response and parturition

H. Uozumi, K. Kume, T. Nagase, H. Nakatani, S. Ishii, F. Tashiro, Y. Komagata, K. Maki, K. Ikuta, Y. Ouchi, J. I. Miyazaki, T. Shimizu

Nature　Vol. 390　No. 6660　p. 618-622　1997　Research paper (scientific journal)

Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade

Yuji Iida, Takao Senda, Yoshihisa Matsukawa, Koji Onoda, Jun-Ichi Miyazaki, Hiromi Sakaguchi, Yuji Nimura, Hiroyoshi Hidaka, Ichiro Niki

American Journal of Physiology - Endocrinology and Metabolism　Vol. 273　No. 4　p. E782-E789　1997　Research paper (scientific journal)

Myeloid differentiation is impaired in transgenic mice with targeted expression of a dominant negative form of retinoid X receptor β

Shinji Sunaga, Kazushige Maki, Eric Lagasse, Jorge C. G. Blanco, Keiko Ozato, Jun-Ichi Miyazaki, Koichi Ikuta

British Journal of Haematology　Vol. 96　No. 1　p. 19-30　1997　Research paper (scientific journal)

In vivo correction with recombinant adenovirus of 4-hydroxyphenylpyruvic acid dioxygenase deficiencies in strain III mice

Shuji Kubo, Kohji Kiwaki, Hisataka Awata, Hideki Katoh, Yumi Kanegae, Izumu Saito, Tetsuro Yamamoto, Jun-Ichi Miyazaki, Ichiro Matsuda, Fumio Endo

Human Gene Therapy　Vol. 8　No. 1　p. 65-71　1997/01/01　Research paper (scientific journal)

Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: Evidences of a human-specific signal transduction pathway for CYP1A1 induction

Hideaki Kikuchi, Hideaki Kato, Masayuki Mizuno, Anwar Hossain, Shuntaro Ikawa, Junichi Miyazaki, Minro Watanabe

Archives of Biochemistry and Biophysics　Vol. 334　No. 2　p. 235-240　1996/10/15　Research paper (scientific journal)

Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10-producing transgenic NOD mice.

Itakura, M, Moritani, M, Yoshimoto, K, Hashimoto, C, Otsuka, S, Sano, T, Miyazaki, J

In Lessons from Animal Diabetes VI. Shafrir, E. ed. (Birkhauser, Boston)　1996/10　Research paper (scientific journal)

Application of a novel B cell line MIN6 to a mesh-reinforced polyvinyl alcohol hydrogel tube and three-layer agarose microcapsules: An in vitro study

H Hayashi, K Inoue, T Aung, T Tun, YJ Gu, WJ Wang, S Shinohara, H Kaji, R Doi, H Setoyama, M Kato, M Imamura, S Maetani, N Morikawa, H Iwata, Y Ikada, J Miyazaki

CELL TRANSPLANTATION　Vol. 5　No. 5　p. S65-S69　1996/09　Research paper (scientific journal)

Two distinct signal pathways activated by activin A in glucose-rsponsive pancreatic β-cell lines.

Shibata, H, Kanazaki, M, Takeuchi, T, Miyazaki, J, Kojima, I

1996/09　Research paper (scientific journal)

Clonal prevalence of T cells infiltrating into the pancreas of prediabetic non-obese diabetic mice.

Komagata, Y, Masuko, K, Tashiro, F, Kato, T, Ikuta, K, Nishioka, K, Ito, K, Miyazaki, J, Yamamoto, K

Int. Immunol.　Vol. 8　No. 6　p. 807-814　1996/08　Research paper (scientific journal)

Interleukin 7 receptor-deficient mice lack γδ T cells

Kazushige Maki, Shinji Sunaga, Yoshinori Komagata, Yuzo Kodaira, Ayako Mabuchi, Hajime Karasuyama, Kozo Yokomuro, Jun-Ichi Miyazaki, Koichi Ikuta

Proceedings of the National Academy of Sciences of the United States of America　Vol. 93　No. 14　p. 7172-7177　1996/07/09　Research paper (scientific journal)

Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription.

Watada, H, Kajimoto, Y, Kaneto, H, Matsuoka, T, Fujitani, Y, Miyazaki, J, Yamasaki, Y

Biochem. Biophys. Res. Commun.　1996/07　Research paper (scientific journal)

Long survival of xenografted bioartificial pancreas with a mesh-reinforced polyvinyl alcohol hydrogel bag employing a B-cell line (MIN6)

H Hayashi, K Inoue, T Aung, T Tun, W Wenjing, YJ Gu, S Shinohara, Y Echigo, H Kaji, H Setoyama, Y Kawakami, M Imamura, N Morikawa, H Iwata, Y Ikada, J Miyazaki

TRANSPLANTATION PROCEEDINGS　Vol. 28　No. 3　p. 1428-1429　1996/06　Research paper (scientific journal)

Correction of ornithine transcarbamylase deficiency in adult spfash mice and in OTC-deficient human hepatocytes with recombinant adenoviruses bearing the CAG promoter

Kohji Kiwaki, Yumi Kanegae, Izumu Saito, Satoru Komaki, Kimitoshi Nakamura, Jun-Ichi Miyazaki, Fumio Endo, Ichiro Matsuda

Human Gene Therapy　Vol. 7　No. 7　p. 821-830　1996/05/01　Research paper (scientific journal)

Developmental heterogeneity of V gamma 1.1 T cells in the mouse liver

Y Kodaira, K Yokomuro, S Tanaka, JI Miyazaki, K Ikuta

IMMUNOLOGY　Vol. 87　No. 2　p. 213-219　1996/02　Research paper (scientific journal)

Proprotein-processing endoprotease furin decreases regulated secretory pathway-specific proteins in the pancreatic β cell line MIN6

Tsuyoshi Kayo, Yoshie Sawada, Yoko Suzuki, Masayuki Suda, Shigeyasu Tanaka, Yoshitaka Konda, Jun-Ichi Miyazaki, Toshiyuki Takeuchi

Journal of Biological Chemistry　Vol. 271　No. 18　p. 10731-10737　1996　Research paper (scientific journal)

Identification of genes regulated by glucose in a pancreatic beta-cell line by a new method for subtraction of mRNA

E. Yamato, H. Ikegami, J. I. Miyazaki, T. Ogihara

Diabetologia　Vol. 39　No. 11　p. 1293-1298　1996　Research paper (scientific journal)

GGAAAT motifs play a major role in transcriptional activity of the human insulin gene in a pancreatic islet beta-cell line MIN6

A. Tomonari, K. Yoshimoto, M. Tanaka, H. Iwahana, J. Miyazaki, M. Itakura

Diabetologia　Vol. 39　No. 12　p. 1462-1468　1996　Research paper (scientific journal)

Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells

Hisamitsu Ishihara, Mitsuhiro Nakazaki, Yumi Kanegae, Kouichi Inukai, Tomoichiro Asano, Hideki Katagiri, Yoshio Yazaki, Masatoshi Kikuchi, Jun-Ichi Miyazaki, Izumu Saito, Yoshitomo Oka

Diabetes　Vol. 45　No. 9　p. 1238-1244　1996　Research paper (scientific journal)

Preferential requirement of CD3ζ-mediated signals for development of immature rather than mature thymocytes

Tomohiko Aoe, Yasuhiro Okamoto, Hisashi Arase, Koichi Ikuta, Jun-Ichi Miyazaki, Satoru Ono, Mizuto Otuji, Hiroshi Ohno, Sho-Ichiro Miyatake, Takashi Saito

International Immunology　Vol. 8　No. 7　p. 1055-1066　1996　Research paper (scientific journal)

Efficacy of microencapsulation of a pancreatic B-cell line (MIN6) in an agarose/PSSa microbead as a bioartificial pancreas

W. J. Wang, K. Inoue, H. Hayashi, T. Aung, T. Tun, Y. J. Gu, H. Kaji, Y. Echigo, M. Kato, R. Doi, H. Setoyama, Y. Kawakami, M. Imamura, S. Maetani, N. Morikawa, H. Iwata, Y. Ikada, J. I. Miyazaki

Transplantation Proceedings　Vol. 28　No. 2　p. 1094-1096　1996　Research paper (international conference proceedings)

Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus

Yukako Ozawa, Akira Kasuga, Hiroko Nomaguchi, Taro Maruyama, Tomohiro Kasatani, Akira Shimada, Izumi Takei, Jun-Ichi Miyazaki, Takao Saruta

Journal of Autoimmunity　Vol. 9　No. 4　p. 517-524　1996　Research paper (scientific journal)

Rectification of diabetic state in C57BL/KsJ-db/db mice by the implantation of pancreatic beta cell line MIN6

Seisuke Inada, Shigehiro Kaneko, Kenji Suzuki, Jun-Ichi Miyazaki, Hitoshi Asakura, Michio Fujiwara

Diabetes Research and Clinical Practice　Vol. 32　No. 3　p. 125-133　1996　Research paper (scientific journal)

Xenoimplantation using a diffusion chamber with a B-cell line (MIN6) as a bioartificial endocrine pancreas (Bio-AEP)

Hisako Ohgawara, Jun-Ichi Miyazaki, Yoshihiko Nakagawa, Sumihiko Sato, Sachiyo Karibe, Toshihiro Akaike

Cell Transplantation　Vol. 5　No. 5　p. S71-S73　1996　Research paper (scientific journal)

Defective B-1 cell development and impaired immunity against angiostrongylus cantonensis in IL-5Rα-deficient mice

Toshimi Yoshida, Koichi Ikuta, Hiroko Sugaya, Kazushige Maki, Mineo Takagi, Hiroko Kanazawa, Shinji Sunaga, Tatsuo Kinashi, Kentarou Yoshimura, Jun-Ichi Miyazaki, Satoshi Takaki, Kiyoshi Takatsu

Immunity　Vol. 4　No. 5　p. 483-494　1996　Research paper (scientific journal)

Immune response to heat shock protein correlates with induction of insulitis in I-Ead transgenic NOD mice.

Shimada, A, Kasatani, T, Takei, I, Maruyama, T, Nomaguchi, H, Ozawa, Y, Ishii, M, Kasuga, A, Tashiro, F, Miyazaki, J, Yamamura, K, Saruta, T

Diabetes　1996/01　Research paper (scientific journal)

Calcium as a second messenger of the action of transforming growth factor-βon insulin secretion.

Ishiyama, N, Shibata, H, Kanazaki, M, Shiozaki, S, Miyazaki, J. Kobayashi, I, Kojima, I

1996/01　Research paper (scientific journal)

Xenotransplantation of a novel B-cell line (MIN6) in mesh-reinforced polyvinyl alcohol hydrogel bag

H Hayashi, K Inoue, T Aung, T Tun, Y Echigo, YJ Gu, S Shinohara, H Kaji, M Kato, M Imamura, S Maetani, N Morikawa, H Iwata, Y Ikada, J Miyazaki

TRANSPLANTATION PROCEEDINGS　Vol. 27　No. 6　p. 3358-3361　1995/12　Research paper (scientific journal)

HUMAN GLUT-2 OVEREXPRESSION DOES NOT AFFECT GLUCOSE-STIMULATED INSULIN-SECRETION IN MIN6 CELLS

H ISHIHARA, T ASANO, K TSUKUDA, H KATAGIRI, K INUKAI, M ANAI, Y YAZAKI, J MIYAZAKI, M KIKUCHI, Y OKA

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM　Vol. 269　No. 5　p. E897-E902　1995/11　Research paper (scientific journal)

Efficient regulation of gene expression by adenovirus-mediated delivery of the Cre recombinase.

Sakai, K, Mitani, K, Miyazaki, J

Biochem. Biophys. Res. Commun.　1995/10　Research paper (scientific journal)

INHIBITION OF PANCREATIC BETA-CELL GLUCOKINASE BY ANTISENSE RNA EXPRESSION IN TRANSGENIC MICE - MOUSE STRAIN-DEPENDENT ALTERATION OF GLUCOSE-TOLERANCE

H ISHIHARA, F TASHIRO, K IKUTA, T ASANO, H KATAGIRI, K INUKAI, M KIKUCHI, Y YAZAKI, Y OKA, J MIYAZAKI

FEBS LETTERS　Vol. 371　No. 3　p. 329-332　1995/09　Research paper (scientific journal)

Glucose induces calcium-dependent and calcium-independent insulin secretion from the pancreatic beta cell line MIN6.

Sakuma, N, Ishikawa, S, Okada, K, Miyazaki, J, Saito, T

Eur J. Endocrinol.　1995/09　Research paper (scientific journal)

ASSESSMENT OF PORE-SIZE OF SEMIPERMEABLE-MEMBRANE FOR IMMUNOISOLATION ON XENO-IMPLANTATION OF PANCREATIC B-CELLS

H OHGAWARA, J MIYAZAKI, S KARIBE, F TASHIRO, T AKAIKE

DIABETOLOGIA　Vol. 38　p. A84-A84　1995/08

Ca2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells.

Matsumoto, K, Fukunaga, K, Miyazaki, J, Shichiri, M, Miyamoto, E

Endocrinology　1995/08　Research paper (scientific journal)

Embedded-culture of pancreatic β-cells derived from transgenic mouse insulinoma as a potential source for xenotransplantation using a diffusion chamber.

Ohgawara, H, Miyazaki, J, Karibe, S, Tashiro, F, Akaike, T, Hashimoto, Y

1995/07　Research paper (scientific journal)

A novel isoform of syntaxin-binding protein homologous to yeast SecI expressed ubiquitously in mammalian cells

Katagiri, H, Terasaki, J, Murata, T, Ishihara, H, Ogihara, T, Inukai, K, Fukushima, Y, Anai, M, Kikuchi, M, Miyazaki, J, Yazaki, Y, Oka, Y

J. Biol. Chem.　1995/07　Research paper (scientific journal)

Copy-dependent and position-independent expression of rat aldolase A gene.

Hashido, K, Arai, Y, Kajihara, S, Joh, K, Yatsuki, H, Hori, K, Miyazaki, J, Yamamura, K, Mukai, T

J. Biochem.　1995/06　Research paper (scientific journal)

Expression of intracellular adhesion molecule-1 on pancreatic β-cells accelerates β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes.

Yagi, N, Yokono, K, Amano, K, Nagata, M, Tsukamoto, K, Hasegawa, Y, Yoneda, R, Okamoto, N, Moriyama, H, Miki, M, Tominaga, Y, Miyazaki, J, Yagita, H, Okumura, K, Mizoguchi, A, Miki, A, Ide, C, Maeda, S, Kasuga, M

1995/06　Research paper (scientific journal)

Formation of islet fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

Yagui, K, Yamaguchi, T, Kanatsuka, A, Shimada, F, Huang, C. I, Tokuyama, Y, Ohsawa, H, Yamamura, K, Miyazaki, J, Mikata, A, Yoshida, S, Makino, H

Eur. J. Endocrinol.　1995/05　Research paper (scientific journal)

NITRIC-OXIDE IS IMPORTANT FOR MOUSE BETA-CELL LINE KILLING BY PERITONEAL-EXUDATE CELLS OBTAINED FROM CYCLOPHOSPHAMIDE-TREATED NONOBESE DIABETIC MICE

A KASUGA, T NAKAKI, TAKEI, I, S TAKAYAMA, Y OZAWA, T MARUYAMA, JI MIYAZAKI, T SARUTA

ENDOCRINE JOURNAL　Vol. 42　No. 2　p. 259-263　1995/04　Research paper (scientific journal)

Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase

Kimi Araki, Masatake Araki, Jun-Ichi Miyazaki, Pierre Vassalli

Proceedings of the National Academy of Sciences of the United States of America　Vol. 92　No. 1　p. 160-164　1995/01/03　Research paper (scientific journal)

Assessment of pore size of a semipermeable membrane for immunoisolation on xenoimplantation of pancreatic B cells using a diffusion chamber

H. Ohgawara, J. Miyazaki, S. Karibe, N. Katagiri, F. Tashiro, T. Akaike

Transplantation Proceedings　Vol. 27　No. 6　p. 3319-3320　1995　Research paper (international conference proceedings)

Paracrine IL-10 accelerates autoimmune insulitis and diabetes in transgenic NOD mice

M Itakura, M Moritani, F Tashiro, C Hashimoto, J Miyazaki, S Ii, E Kudo, H Iwahana, Y Hayashi, T Sano, K Yoshimoto

DIABETES 1994　Vol. 1100　p. 540-549　1995　Research paper (international conference proceedings)

An Inhibitory Role for Phosphatidylinositol 3-Kinase in Insulin Secretion from Pancreatic B Cell Line MIN6

Shinji Hagiwara, Takashi Sakurai, Fumi Tashiro, Yoshiaki Hashimoto, Yuzuru Matsuda, Yoshiaki Nonomura, Jun-Ichi Miyazaki

Biochemical and Biophysical Research Communications　Vol. 214　No. 1　p. 51-59　1995　Research paper (scientific journal)

Defective IL-5-receptor-mediated signaling in B cells of X-linked immunodeficient mice

Masamichi Koike, Yuji Kikuchi, Akira Tominaga, Satoshi Takaki, Kiwamu Akagi, Jun-ichi Miyazaki, Ken-ichi Yamamura, Kiyoshi Takatsu

International Immunology　Vol. 7　No. 1　p. 21-30　1995/01　Research paper (scientific journal)

Genetic analysis of very fast sedimenting DNA of bacteriophage T4.

Miyazaki, J, Ryo, Y, Minagawa, T

Jpn. J. Genet. 60　1995/01　Research paper (scientific journal)

Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice

Maki Moritanl, Katsuhiko Yoshimoto, Fumi Tashiro, Chikara Hashimoto, Jun-ichi Miyazakl, Setsuko Li, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano, Mitsuo Itakura

International Immunology　Vol. 6　No. 12　p. 1927-1936　1994/12　Research paper (scientific journal)

Bimodal effect of transforming growth factor-β on insulin secretion in MIN6 cells.

Sekine, N, Yamashita, N, Kojima, I, Miyazaki, J, Ogata, E

1994/10　Research paper (scientific journal)

Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6.

Gonoi, T, Mizuno, N, Inagaki, N, Kuromi, H, Seino, Y, Miyazaki, J, Seino, S

J. Biol. Chem.　1994/10　Research paper (scientific journal)

Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells.

Inagaki, N, Yoshida, H, Mizuta, M, Mizuno, N, Fujii, Y, Gonoi, T, Miyazaki, J, Seino, S

Proc. Natl. Acad. Sci. USA.　1994/10　Research paper (scientific journal)

Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration-dependency of glucose-stimulated insulin secretion in pancreatic β-cell line MIN6.

Ishihara, H, Asano, T, Tsukuda, K, Katagiri, H, Inukai, K, Anai, M, Kikuchi, M, Yazaki, Y, Miyazaki, J, Oka, Y

1994/10　Research paper (scientific journal)

Activity assays of nine heterogeneous promoters in neural and other cultured cells.

Fukuchi, K, Hearn, M.G, Deeb, S.S, Smith, A.C, Dang, N, Miyazaki, J, Bothwell, M, Martin, G.M

In Vitro Cell. Dev. Biol.　1994/07　Research paper (scientific journal)

Embedded-culture of pancreatic b-cells derived from transgenic mouse insulinoma as a potential source for xenotransplantation using a diffusion chamber.

Ohgawara, H, Miyazaki, J, Karibe, S, Tashiro, F, Akaike, T, Hashimoto, Y

Cell Transpl.　1994/06　Research paper (scientific journal)

Effect of secretin on glucose-stimulated insulin release from MIN6 cells.

Kato, M, Imamura, M, Okada, N, Doi, R, Hashimoto, M, Shimada, Y, Miyazaki, J

Biomed. Res. 15 (Suppl. 2)　1994/06　Research paper (scientific journal)

Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice

Nishiyama Toshihiko, Shirotani Tetsuya, Murakami Takashi, Shimada Fumio, Todaka Mikio, Saito Seiichiro, Hayashi Hideki, Noma Yoshihiko, Shima Kenji, Makino Hideichi, Shichiri Motoaki, Miyazaki Jun-ichi, Yamamura Ken-ichi, Ebina Yousuke

Gene　Vol. 141　No. 2　p. 187-192　1994/04/20　Research paper (scientific journal)

HEPATOCYTE GROWTH-FACTOR SPECIFICALLY BINDS TO SULFOGLYCOLIPIDS

T KOBAYASHI, K HONKE, T MIYAZAKI, K MATSUMOTO, T NAKAMURA, ISHIZUKA, I, A MAKITA

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 269　No. 13　p. 9817-9821　1994/04　Research paper (scientific journal)

Acceleration of diabetes in young NOD mice with peritoneal macrophages.

Shimada, A, Takei, I, Maruyama, T, Kasuga, A, Kasatani, T, Watanabe, K, Asaba, Y, Ishii, T, Tadakuma, T, Habu, S, Miyazaki, J, Saruta, T

Diab. Res. Clin. Pract.　1994/03　Research paper (scientific journal)

Inhibition of ATP-sensitive K+ channel by a nonsulfonylurea compound KAD-1229 in a pancreatic b-cell line, MIN6 cell.

Mogami, H, Shibata, H, Nobusawa, R, Ohnota, H, Satou, F, Miyazaki, J, Kojima, I

Eur. J. Phamacol.　1994/03　Research paper (scientific journal)

Embryonic Expression of MHC Class I Heavy and Light Chains in Transgenic Mice

Masatoshi Ishii, Fumi Tashiro, Shinji Hagiwara, Jun-Ichi Miyazaki, Chikara Hashimoto, Izumi Takei, Ken-Ichi Yamamura, Tetsushi Toyonaga

endocrine journal　Vol. 41　1994　Research paper (scientific journal)

RESISTANCE TO CYCLOPHOSPHAMIDE-INDUCED DIABETES IN TRANSGENIC NOD MICE EXPRESSING I-A(K)

F TASHIRO, A KASUGA, A SHIMADA, M ISHII, TAKEI, I, T MIYAZAKI, KI YAMAMURA, JI MIYAZAKI

AUTOIMMUNITY　Vol. 17　No. 3　p. 181-188　1994　Research paper (scientific journal)

Transgenic models of insulin-dependent diabetes mellitus.

Miyazaki, J, Tashiro, F

1994/01　Research paper (scientific journal)

Response to glucose of transcription factor binding to the rat insulin-I gene promoter.

Goodison, S, Miyazaki, J, Ashcroft, S.J.H

Biochem. Biophy. Res. Commun.　1994/01　Research paper (scientific journal)

PANCREATIC BETA-CELL LINE MIN6 EXHIBITS CHARACTERISTICS OF GLUCOSE-METABOLISM AND GLUCOSE-STIMULATED INSULIN-SECRETION SIMILAR TO THOSE OF NORMAL ISLETS

H ISHIHARA, T ASANO, K TSUKUDA, H KATAGIRI, K INUKAI, M ANAI, M KIKUCHI, Y YAZAKI, JI MIYAZAKI, Y OKA

DIABETOLOGIA　Vol. 36　No. 11　p. 1139-1145　1993/11　Research paper (scientific journal)

Molecular cloning of the cDNAs for the subunits of rat mitochondrial fatty acid β-oxidation multienzyme complex : stuctural and functional relationships to other mitochondrial and peroxisomal β-oxidation enzymes.

Kamijo, T, Aoyama, T, Miyazaki J, Hashimoto, T

1993/10　Research paper (scientific journal)

The role of cytotoxic macrophages in non-obese diabetic mice : cytotoxicity against murine mastocytoma and beta-cell lines.

Kasuga, A, Maruyama, T, Takei, I, Shimada, A, Kasatani, T, Watanabe, K, Saruta, T, Nakaki, T, Habu, S, Miyazaki, J

Diabetologia　1993/08　Research paper (scientific journal)

Relation between glucose-stimulated insulin secretion and intracellular calcium accumulation studied with a superfusion system of a glucose-resposive pancreatic β-cell line MIN6.

Sakurada, M, Kanatsuka, A, Saitoh, T, Makino, H, Yamamura, K, Miyazaki, J, Kikuchi, M, Yoshida, S

1993/07　Research paper (scientific journal)

Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing α1(IX) collagen chains with a central deletion.

Nakata, K, Ono, K, Miyazaki, J, Olsen, B. R, Muragaki, Y, Adachi, E, Yamamura, K, Kimura, A

1993/06　Research paper (scientific journal)

Efficient production of recombinant human factor VIII by co-expression of the heavy and light chains.

Yonemura, A, Sugawara, K, Nakashima, K, Nakahara, Y, Hamamoto, T, Mimaki, I, Yokomizo, K, Tajima, Y, Masuda, K, Imaizumi, A, Funatsu, A, Miyazaki, J

Prot. Engineering　1993/05　Research paper (scientific journal)

EFFECT OF EMBRYONIC EXPRESSION OF MHC CLASS I ANTIGEN ON THE MATERNAL IMMUNE RESPONSE TO THE FETUS

Tashiro F., Yamamura K., Miyazaki J.

Nihon Seishokumeneki Gakkai Zassi　Vol. 7　p. 65-71　1993

NONSENSE MUTATION OF GLUCOKINASE GENE IN LATE-ONSET NON-INSULIN-DEPENDENT DIABETES-MELLITUS

H KATAGIRI, T ASANO, H ISHIHARA, K INUKAI, M ANAI, J MIYAZAKI, K TSUKUDA, M KIKUCHI, Y YAZAKI, Y OKA

LANCET　Vol. 340　No. 8831　p. 1316-1317　1992/11　Research paper (scientific journal)

PREVENTION OF AUTOIMMUNE INSULITIS IN NONOBESE DIABETIC MICE BY EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I LD-MOLECULES

T MIYAZAKI, Y MATSUDA, T TOYONAGA, J MIYAZAKI, Y YAZAKI, K YAMAMURA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 89　No. 20　p. 9519-9523　1992/10　Research paper (scientific journal)

Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair.

I Miyamoto, N Miura, H Niwa, J Miyazaki, K Tanaka

Journal of Biological Chemistry　Vol. 267　No. 17　p. 12182-12187　1992/06　Research paper (scientific journal)

DEVELOPMENTAL AND LIVER-SPECIFIC EXPRESSION DIRECTED BY THE SERUM AMYLOID-P COMPONENT PROMOTER IN TRANSGENIC MICE

ZHAO, X, K ARAKI, J MIYAZAKI, K YAMAMURA

JOURNAL OF BIOCHEMISTRY　Vol. 111　No. 6　p. 736-738　1992/06　Research paper (scientific journal)

STRAIN DEPENDENCY OF CELL-TYPE SPECIFICITY AND ONSET OF LYMPHOMA DEVELOPMENT IN E-MU-MYC TRANSGENIC MICE

K AKAGI, J MIYAZAKI, K YAMAMURA

JAPANESE JOURNAL OF CANCER RESEARCH　Vol. 83　No. 3　p. 269-273　1992/03　Research paper (scientific journal)

CHARACTERIZATION OF T-CELL TOLERANCE TO HEPATITIS-B VIRUS (HBV) ANTIGEN IN TRANSGENIC MICE

H TAKASHIMA, K ARAKI, J MIYAZAKI, K YAMAMURA, M KIMOTO

IMMUNOLOGY　Vol. 75　No. 3　p. 398-405　1992/03　Research paper (scientific journal)

Islet amyloid polypeptide/amylin in pancreatic β-cell line derived from transgenic mouse insulinoma

A. Kanatsuka, H. Makino, T. Yamaguchi, H. Ohsawa, Y. Tokuyama, T. Saitoh, K. I. Yamamura, J. I. Miyazaki, S. Yoshida

Diabetes　Vol. 41　No. 11　p. 1409-1414　1992　Research paper (scientific journal)

Transgenic mouse as a tool for the study of autoimmune disease: Insulin-dependent diabetes mellitus

Ken-Ichi Yamamura, Miyazaki Tohru, Masashi Uno, Jun-Ichi Miyazaki

International Journal of Immunopharmacology　Vol. 14　No. 3　p. 451-455　1992　Research paper (scientific journal)

A murine thymic stromal cell line which may support the differentiation of CD4-8- thymocytes into CD4+8- αβ T cell receptor positive T cells

Yoshihiro Watanabe, Osam Mazda, Yu-Ichi Aiba, Kazuhiro Iwai, Jun-Ichiro Gyotoku, Shin Ideyama, J. Miyazaki, Yoshimoto Katsura

Cellular Immunology　Vol. 142　No. 2　p. 385-397　1992　Research paper (scientific journal)

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice

Sachiko Suematsu, Taiji Matsusaka, Tadashi Matsuda, Shinsuke Ohno, Jun-Ichi Miyazaki, Ken-Ichi Yamamura, Toshio Hirano, Tadamitsu Kishimoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 89　No. 1　p. 232-235　1992　Research paper (scientific journal)

Non-obese diabetic transgenic mice.

Yamamura, K, Miyazaki, T, Uno, M, Toyonaga, T, Miyazaki, J

Springer Sem. Immunopathol.　1992/01　Research paper (scientific journal)

Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules

Masashi Uno, Toru Miyazaki, Masahiro Uehira, Hirofumi Nishimoto, Masao Kimoto, Junichi Miyazaki, Ken-ichi Yamamura

Immunology Letters　Vol. 31　No. 1　p. 47-52　1992　Research paper (scientific journal)

Development of two types of hepatocellular carcinoma in transgenic mice carrying the SV40 large T-antigen gene

Kimi Araki, Okio Hino, Jun-ichi Miyazaki, Ken-ichi Yamamura

Carcinogenesis　Vol. 12　No. 11　p. 2059-2062　1991/11　Research paper (scientific journal)

(BALB/CXC57BL/6)F1 MICE ARE TOLERANT TO UNDETECTABLE MIXED HAPLOTYPE A-BETA-DA-ALPHA-B AND MIXED ISOTYPE A-BETA-DE-ALPHA-D SELF CLASS-II MOLECULES

T MINETA, M MATSUNAGA, H TAKASHIMA, M UNO, J MIYAZAKI, K YAMAMURA, M KIMOTO

INTERNATIONAL IMMUNOLOGY　Vol. 3　No. 5　p. 453-460　1991/05　Research paper (scientific journal)

Rapid identification of transgenic mice with PCR amplification of DNA from ear punching.

Qi, S. -L, Akagi, K, Araki, K, Miyazaki, J, Yamamura, K

Methods in Mol. Cell. Biol.　1991/02　Research paper (scientific journal)

Efficient selection for high-expression transfectants with a novel eukaryotic vector.

Niwa, H, Yamamura, K, Miyazaki, J

Gene　1991/02　Research paper (scientific journal)

PREVENTION OF AUTOIMMUNE INSULITIS IN NOD TRANSGENIC MICE

H NISHIMOTO, M UEHIRA, T KURNER, T MIYAZAKI, M UNO, N NAKANO, H KIKUTANI, J MIYAZAKI, T KISHIMOTO, K YAMAMURA

FRONTIERS OF MUCOSAL IMMUNOLOGY, VOL 2　Vol. 939　p. 425-428　1991　Research paper (international conference proceedings)

L-e-restricted monoclonal expansion of b lymphocytes in the thymus of nod mouse

Kenji Watanabe, Reiko Tanaka, Takashi Nishimura, Yoshihiro Kumagai, Jun-Ichi Miyazaki, Ken-Ichi Yamamura, Sonoko Habu

International Immunology　Vol. 3　No. 8　p. 839-842　1991　Research paper (scientific journal)

Differentiation of growth signal requirement of B lymphocyte precursor is̀ directed by expression of immunoglobulin

Takumi Era, Minetaro Ogawa, Shin-Ichi Nishikawa, Masaya Okamoto, Tasuku Honjo, Kiwamu Akagi, Jun-Ichi Miyazaki, Ken-Ichi Yamamura

EMBO Journal　Vol. 10　No. 2　p. 337-342　1991　Research paper (scientific journal)

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production

A. Tominaga, S. Takaki, N. Koyama, S. Katoh, R. Matsumoto, M. Migita, Y. Hitoshi, Y. Hosoya, S. Yamauchi, Y. Kanai, J. I. Miyazaki, G. Usuku, K. I. Yamamura, K. Takatsu

Journal of Experimental Medicine　Vol. 173　No. 2　p. 429-437　1991　Research paper (scientific journal)

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice

G. Yamada, M. Ogawa, K. Akagi, H. Miyamoto, N. Nakano, S. Itoh, J. I. Miyazaki, S. I. Nishikawa, K. I. Yamamura, T. Taniguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 88　No. 2　p. 532-536　1991　Research paper (scientific journal)

Production and Effect of Infectious Dane Particles in Transgenic Mice

Kimi Araki, Shinichiro Nishimura, Takahiro Ochiya, Kousaku Okubo, Jun‐ichi Miyazaki, Kenichi Matsubara, Ken‐ichi Yamamura

Japanese Journal of Cancer Research　Vol. 82　No. 3　p. 235-239　1991　Research paper (scientific journal)

SUPPRESSION OF MURINE LEUKEMIA VIRUS-MEDIATED 3Y1 CELL-FUSION BY EXPRESSION OF MOUSE MHC CLASS-I

N MOMOZAKI, H OGURA, J MIYAZAKI, S MATSUHASHI, K JOH, G KIMURA, K TABUCHI, K HORI

ARCHIVES OF VIROLOGY　Vol. 119　No. 1-2　p. 43-52　1991　Research paper (scientific journal)

Tissue-specific expression of rat pyruvate kinase L/chloramphenicol acetyltransferase fusion gene in transgenic mice and its regulation by diet and insulin

Kazuya Yamada, Tamio Noguchi, Jun ichi Miyazaki, Tamiko Matsuda, Masaru Takenaka, Ken ichi Yamamura, Takehiko Tanaka

Biochemical and Biophysical Research Communications　Vol. 171　No. 1　p. 243-249　1990/08/31　Research paper (scientific journal)

HBV production in transgenic mice.

Yamamura, K, Araki, K, Hino, O, Tomita, N, Miyazaki, J, Matsubara, K

Gastroenterologia Japonica　Vol. 25　No. 2　p. 49-52　1990/05　Research paper (scientific journal)

Correlation of Tissue‐specific Methylation with Gene Inactivity in Hepatitis B Virus Transgenic Mice

Kimi Araki, Kiwamu Akagi, Jun‐ichi Miyazaki, Kenichi Matsubara, Ken‐ichi Yamamura

Japanese Journal of Cancer Research　Vol. 81　No. 12　p. 1265-1271　1990　Research paper (scientific journal)

Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

Toru Miyazaki, Masashi Uno, Masahiro Uehira, Hitoshi Kikutani, Tadamitsu Kishimoto, Masao Kimoto, Hirofumi Nishimoto, Jun-Ichi Miyazaki, Ken-Ichi Yamamura

Nature　Vol. 345　No. 6277　p. 722-724　1990　Research paper (scientific journal)

IGG1 PLASMACYTOSIS IN INTERLEUKIN-6 TRANSGENIC MICE

S SUEMATSU, T MATSUDA, K AOZASA, S AKIRA, N NAKANO, S OHNO, J MIYAZAKI, K YAMAMURA, T HIRANO, T KISHIMOTO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 86　No. 19　p. 7547-7551　1989/10　Research paper (scientific journal)

Expression vector system based on the chicken -actin promoter directs efficient production of interleukin-5.

Miyazaki, J, Takaki, S, Araki, K, Tashiro, F, Tominaga, A, Takatsu, K, Yamamura, K

1989/08　Research paper (scientific journal)

Development of autoimmune insulitis is prevented in Eαd but not in Aβk NOD transgenic mice

Masahiro Uehira, Masashi Uno, Thomas Kürner, Hitoshi Kikutani, Koh-ichi Mori, Takeaki Inomoto, Toshimitsu Uede, Jun-ichi Miyazaki, Hirofumi Nishimoto, Tadamitsu Kishimoto, Ken-ichi Yamamura

International Immunology　Vol. 1　No. 2　p. 209-213　1989/05　Research paper (scientific journal)

Expression and replication of hepatitis B virus genome in transgenic mice.

Araki, K, Miyazaki, J, Hino, O, Tomita, N, Chisaka, O, Matsubara, K, Yamamura, K

Proc. Natl. Acad. Sci. USA.　1989/02　Research paper (scientific journal)

LIVER-SPECIFIC AND HIGH-LEVEL EXPRESSION OF HUMAN-SERUM AMYLOID-P COMPONENT GENE IN TRANSGENIC MICE

T IWANAGA, S WAKASUGI, T INOMOTO, M UEHIRA, S OHNISHI, S NISHIGUCHI, K ARAKI, M UNO, J MIYAZAKI, S MAEDA, K SHIMADA, K YAMAMURA

DEVELOPMENTAL GENETICS　Vol. 10　No. 5　p. 365-371　1989　Research paper (scientific journal)

Demethylation by 5‐Azacytidine Results in the Expression of Hepatitis B Virus Surface Antigen in Transgenic Mice

Kimi Araki, Jun‐ichi Miyazaki, Toshiki Tsurimoto, Takeaki Inomoto, Tomohisa Iwanaga, Kenichi Matsubara, Ken‐ichi Yamamura

Japanese Journal of Cancer Research　Vol. 80　No. 4　p. 295-298　1989　Research paper (scientific journal)

FUNCTIONAL EXPRESSION OF GENES INVOLVED IN IMMUNE-RESPONSE IN TRANSGENIC MICE

K YAMAMURA, H NISHIMOTO, J MIYAZAKI, M UEHIRA, H KIKUTANI, T KISHIMOTO

BIOLOGISCHES ZENTRALBLATT　Vol. 108　No. 1　p. 31-33　1989/01　Research paper (scientific journal)

Expression Vector System Based on the Chicken-β-actin Promoter Directs Efficient Production of Interleukin-5

J.Miyazaki, S.Takaki, K.Araki, F.Tashiro, A.Tominaga, K.Takatsu, K.Yamamura

1989/01　Research paper (scientific journal)

A potential animal model for familial amyloidotic polyneuropathy through introduction of human mutant transthyretin gene into mice. In Amyloid and Amyloidosis.

Wakasugi, S, Inomoto, T, Yi, S, Naito, M, Uehira, M, Iwanaga, T, Maeda, S, Araki, K, Miyazaki, J, Takahashi, K, Shimada, K, Yamamura, K

Isobe, T., Araki, S., Uchino, F., Kito, S. & Tsubura, E. eds. Isobe, T., Araki, S., Uchino, F., Kito, S. & Tsubura, E. eds.(Plenum Publishing Co., New York).　1988/11　Research paper (scientific journal)

Establishment of cell lines from somite stage mouse embryos and expression of major histocompatibility class I genes in these cells.

Silverman, T, Rein, A, Orrison, B, Langloss, J, Bratthauer, G, Miyazaki, J, Ozato, K

J. Immunol.　1988/10　Research paper (scientific journal)

AN AUTOSOMAL DOMINANT MUTATION OF FACIAL DEVELOPMENT IN A TRANSGENIC MOUSE

S WAKASUGI, T IWANAGA, T INOMOTO, T TENGAN, S MAEDA, M UEHIRA, K ARAKI, J MIYAZAKI, K ETO, K SHIMADA, K YAMAMURA

DEVELOPMENTAL GENETICS　Vol. 9　No. 3　p. 203-212　1988　Research paper (scientific journal)

Ozato, K., Koeller, D., Lieberman, R., Miyazaki, J., Appella, E., Mann, D. W. & Forman, J.

Site directed, mutagenesis indentifies allo-antigenic epitopes of an H, antigen recognized by, antibodies, by cytotoxic T-lymphocytes

In H-2 Antigens. David, C. S. ed. (Plenum Publishing Co., New York).　1987/10　Research paper (scientific journal)

Binding of multiple nuclear factors to the 5' regulatory element of the major histocompatibility class I gene.

Shirayoshi, Y, Miyazaki, J, Burke, P, Hamada, K, Appella, E, Ozato, K

Mol. Cell. Biol.　1987/10　Research paper (scientific journal)

Interferons increase transcription of a major histocompatibility class I gene via 5' interferon consensus sequence.

Sugita, K, Miyazaki, J, Appella, E, Ozato, K

Mol. Cell. Biol.　1987/10　Research paper (scientific journal)

Binding of multiple nuclear factors to the 5' regulqtory element of the major histocompatibility class I gene.

Shirayoshi, Y, Miyazaki, J, Burke, P, Hamada, K, Appella, E, Ozato, K

Mol. Cell. Biol. 7　1987/09　Research paper (scientific journal)

Introduction of H-2Dd determinants into the H-2Ld antigen by site-directed mutagenesis.

Koeller, D, Lieberman, R, Miyazaki, J, Appella, E, Ozato, K, Mann, D. W, Forman, J

J. Exp. Med.　1987/06　Research paper (scientific journal)

Site directed mutagenesis indentifies allo-antigenic epitopes of an H-2 antigen recognized by antibodies and by cytotoxic T-lymphocytes. In H-2 Antigens.

Ozato, K, Koeller, D, Lieberman, R, Miyazaki, J, Appella, E, Mann, D. W, Forman, J

David, C. S. ed. (Plenum Publishing Co., New York).　1987/05　Research paper (scientific journal)

Transacting nuclear proteins that bind to the upstream regulatory region of a MHC class I gene. In H-2 Antigens.

Ozato, K, Shirayoshi, Y, Burke, P, Appella, E, Miyazaki, J

David, C. S. ed. (Plenum Publishing Co., New York).　1987/04　Research paper (scientific journal)

A transgenic mouse model of familial amyloidotic polyneuropathy.

Wakasugi, S, Inomoto, T, Yi, S, Naito, M, Uehira, M, Iwanaga, T, Maeda, S, Araki, K, Miyazaki, J, Takahashi, K, Shimada, K, Yamamura, K

Proc. Jpn. Acad.　Vol. 51　No. 4　p. 309-316　1987/03　Research paper (scientific journal)

TISSUE-SPECIFIC AND DEVELOPMENTAL EXPRESSION OF HUMAN TRANSTHYRETIN GENE IN TRANSGENIC MICE

K YAMAMURA, S WAKASUGI, S MAEDA, T INOMOTO, T IWANAGA, M UEHIRA, K ARAKI, J MIYAZAKI, K SHIMADA

DEVELOPMENTAL GENETICS　Vol. 8　No. 4　p. 195-205　1987　Research paper (scientific journal)

Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells.

Miyazaki, J, Appella, E, Ozato, K

Proc. Natl. Acad. Sci. USA.　1986/10　Research paper (scientific journal)

Intracellular transport blockade caused by disruption of the disulfide bridge in the third external domain of major histocompatibility complex class I antigen.

Miyazaki, J, Appella, E, Ozato, K

Proc. Natl. Acad. Sci. USA.　1986/05　Research paper (scientific journal)

Expression and function of a nonglycosylated major histocompatibility class I antigen.

Miyazaki, J, Appella, E, Zhao, H, Forman, J, Ozato, K

J. Exp. Med.　Vol. 163　No. 4　p. 856-871　1986/03　Research paper (scientific journal)

GENETIC-ANALYSIS OF VERY FAST SEDIMENTING DNA OF BACTERIOPHAGE-T4

J MIYAZAKI, Y RYO, T MINAGAWA

JAPANESE JOURNAL OF GENETICS　Vol. 60　No. 1　p. 1-9　1985　Research paper (scientific journal)

Genetic studies on non-lethal recombination gene mutants of bacteriophage T4.

Yonesaki, T, Miyazaki, J, Minagawa, T

Mem. Fac. Sci. Kyoto Univ. Ser. Biol.　1984/08　Research paper (scientific journal)

INVOLVEMENT OF GENE-49 IN RECOMBINATION OF BACTERIOPHAGE-T4

J MIYAZAKI, Y RYO, T MINAGAWA

GENETICS　Vol. 104　No. 1　p. 1-9　1983　Research paper (scientific journal)

ISOLATION AND CHARACTERIZATION OF BACTERIOPHAGE-T3 MUTANTS SENSITIVE TO RESTRICTION BY ECORI

J MIYAZAKI, H FUJISAWA, Y RYO, T MINAGAWA

VIROLOGY　Vol. 122　No. 1　p. 1-7　1982　Research paper (scientific journal)

Biological activity of purified bacteriophage T3 prohead and prohead-like structures as precursors for in vitro head assembly.

Miyazaki, J, Minagawa, T, Fujisawa, H

Virology　1978/07　Research paper (scientific journal)

In vitro packaging of phage T3 DNA

Hisao Fujisawa, Jun-Ichi Miyazaki, Teiichi Minagawa

Virology　Vol. 87　No. 2　p. 394-400　1978/06　Research paper (scientific journal)

Mutation in bacteriophage T3 affecting host cell lysis.

Miyazaki, J, Ryo, Y, Fujisawa, H, Minagawa, T

Virology　1978/04　Research paper (scientific journal)