Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1.

Yi-Shi Liu, Yicheng Wang, Xiaoman Zhou, Linpei Zhang, Ganglong Yang, Xiao-Dong Gao, Yoshiko Murakami, Morihisa Fujita, Taroh Kinoshita

The Journal of cell biology　Vol. 222　No. 5　2023/05/01　Research paper (scientific journal)

A point mutation in GPI-attachment signal peptide accelerates the development of prion disease.

Atsushi Kobayashi, Tetsuya Hirata, Taishi Shimazaki, Yoshiko Munesue, Keisuke Aoshima, Takashi Kimura, Junko Nio-Kobayashi, Rie Hasebe, Atsuko Takeuchi, Yuichi Matsuura, Satoshi Kusumi, Daisuke Koga, Yasushi Iwasaki, Taroh Kinoshita, Shirou Mohri, Tetsuyuki Kitamoto

Acta neuropathologica　Vol. 145　No. 5　p. 637-650　2023/05　Research paper (scientific journal)

Mitigating Drug-Target-Drug Complexes in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Switch C5 Inhibitors.

Jun-Ichi Nishimura, Antoine Soubret, Noriko Arase, Simon Buatois, Masaki Hotta, Jean-Eric Charoin, Yoshikazu Ito, Sasha Sreckovic, Hiroyuki Takamori, Christoph Bucher, Yasutaka Ueda, Jules Hernández-Sánchez, Keisuke Gotanda, Gregor Jordan, Kenji Shinomiya, Julia Ramos, Jin Seok Kim, Jens Panse, Régis Peffault de Latour, Alexander Röth, Eiichi Morii, Hubert Schrezenmeier, Yoshitaka Isaka, Simona Sica, Yuzuru Kanakura, Sung-Soo Yoon, Taroh Kinoshita, Ido Paz-Priel, Alexandre Sostelly

Clinical pharmacology and therapeutics　Vol. 113　No. 4　p. 904-915　2023/04　Research paper (scientific journal)

Case report: Functional analysis of the p.Arg507Trp variant of the PIGT gene supporting the moderate epilepsy phenotype of mutations in the C-terminal region.

Ikhlas Ben Ayed, Olfa Jallouli, Yoshiko Murakami, Amal Souissi, Salma Mallouli, Amal Bouzid, Fatma Kamoun, Ines Elloumi, Fakher Frikha, Abdelaziz Tlili, Sarah Weckhuysen, Taroh Kinoshita, Chahnez Charfi Triki, Saber Masmoudi

Frontiers in neurology　Vol. 14　p. 1092887-1092887　2023/03　Research paper (scientific journal)

Excluding Digenic Inheritance of PGAP2 and PGAP3 Variants in Mabry Syndrome (OMIM 239300) Patient: Phenotypic Spectrum Associated with PGAP2 Gene Variants in Hyperphosphatasia with Mental Retardation Syndrome-3 (HPMRS3).

Miles D Thompson, Xueying Li, Michele Spencer-Manzon, Danielle M Andrade, Yoshiko Murakami, Taroh Kinoshita, Thomas O Carpenter

Genes　Vol. 14　No. 2　2023/01/30　Research paper (scientific journal)

Biallelic variants in PIGN cause Fryns syndrome, multiple congenital anomalies-hypotonia-seizures syndrome, and neurologic phenotypes: A genotype-phenotype correlation study.

Lucy Loong, Agostina Tardivo, Alexej Knaus, Mona Hashim, Alistair T Pagnamenta, Kerstin Alt, Helena Böhrer-Rabel, Alfonso Caro-Llopis, Trevor Cole, Felix Distelmaier, Patrick Edery, Carlos R Ferreira, Aleksandra Jezela-Stanek, Bronwyn Kerr, Gerhard Kluger, Peter M Krawitz, Marius Kuhn, Johannes R Lemke, Gaetan Lesca, Sally Ann Lynch, Francisco Martinez, Caroline Maxton, Hanna Mierzewska, Sandra Monfort, Joost Nicolai, Carmen Orellana, Deb K Pal, Rafał Płoski, Oliver W Quarrell, Monica Rosello, Małgorzata Rydzanicz, Ataf Sabir, Robert Śmigiel, Alexander P A Stegmann, Helen Stewart, Constance Stumpel, Elżbieta Szczepanik, Andreas Tzschach, Lynne Wolfe, Jenny C Taylor, Yoshiko Murakami, Taroh Kinoshita, Allan Bayat, Usha Kini

Genetics in medicine : official journal of the American College of Medical Genetics　Vol. 25　No. 1　p. 37-48　2023/01　Research paper (scientific journal)

Sequential hydrolysis of FAD by ecto-5' nucleotidase CD73 and alkaline phosphatase is required for uptake of vitamin B2 into cells.

Natsuki Shichinohe, Daisuke Kobayashi, Ayaka Izumi, Kazuya Hatanaka, Rio Fujita, Taroh Kinoshita, Norimitsu Inoue, Naoya Hamaue, Keiji Wada, Yoshiko Murakami

The Journal of biological chemistry　Vol. 298　No. 12　p. 102640-102640　2022/12　Research paper (scientific journal)

【補体と疾患-いま補体がおもしろい-】補体活性化とその制御

井上 徳光, 木下 タロウ

日本臨床　Vol. 80　No. 11　p. 1706-1712　2022/11　Research paper (other academic)

Case report: Functional characterization of a de novo c.145G>A p.Val49Met pathogenic variant in a case of PIGA-CDG with megacolon.

Roberta Salinas-Marín, Yoshiko Murakami, Carlos Alberto González-Domínguez, Mario Ernesto Cruz-Muñoz, Héctor Manuel Mora-Montes, Eva Morava, Taroh Kinoshita, Susana Monroy-Santoyo, Iván Martínez-Duncker

Frontiers in genetics　Vol. 13　p. 971473-971473　2022/10　Research paper (scientific journal)

ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence.

Tetsuya Hirata, Jing Yang, Seita Tomida, Yuko Tokoro, Taroh Kinoshita, Morihisa Fujita, Yasuhiko Kizuka

The Journal of biological chemistry　Vol. 298　No. 10　p. 102444-102444　2022/10　Research paper (scientific journal)

C18orf32 loss-of-function is associated with a neurodevelopmental disorder with hypotonia and contractures.

Smrithi Salian, Xin-Yu Guo, Yoshiko Murakami, Taroh Kinoshita, Parneet Kaur, Anju Shukla, Katta M Girisha, Morihisa Fujita, Philippe M Campeau

Human genetics　Vol. 141　No. 8　p. 1423-1429　2022/08/01　Research paper (scientific journal)

Requirement of sequential hydrolysis by CD73 and ALP for uptake of vitamin B₂ into cells

Natsuki Shichinohe, Daisuke Kobayashi, Ayaka Izumi, Kazuya Hatanaka, Rio Fujita, Taroh Kinoshita, Norimitsu Inoue, Naoya Hamaue, Keiji Wada, Yoshiko Murakami

2022/07/21

Ethanolamine-phosphate on the second mannose is a preferential bridge for some GPI-anchored proteins.

Mizuki Ishida, Yuta Maki, Akinori Ninomiya, Yoko Takada, Philippe Campeau, Taroh Kinoshita, Yoshiko Murakami

EMBO reports　Vol. 23　No. 7　2022/07/05　Research paper (scientific journal)

Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy.

Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-Ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami

Nature communications　Vol. 13　No. 1　p. 3107-3107　2022/06/03　Research paper (scientific journal)

Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis.

Yicheng Wang, Anant K Menon, Yuta Maki, Yi-Shi Liu, Yugo Iwasaki, Morihisa Fujita, Paula A Guerrero, Daniel Varó'n Silva, Peter H Seeberger, Yoshiko Murakami, Taroh Kinoshita

Proceedings of the National Academy of Sciences of the United States of America　Vol. 119　No. 14　2022/04/05　Research paper (scientific journal)

Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.

Tetsuya Hirata, Atsushi Kobayashi, Tamio Furuse, Ikuko Yamada, Masaru Tamura, Hiroyuki Tomita, Yuko Tokoro, Akinori Ninomiya, Yoshitaka Fujihara, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, Yasuhiko Kizuka, Taroh Kinoshita

The Journal of biological chemistry　Vol. 298　No. 3　p. 101720-101720　2022/03/01　Research paper (scientific journal)

Differential use of p24 family members as cargo receptors for the transport of glycosylphosphatidylinositol-anchored proteins and Wnt1.

Yuko Tashima, Tetsuya Hirata, Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita

Journal of biochemistry　Vol. 171　No. 1　p. 75-83　2022/01/07　Research paper (scientific journal)

Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides.

Paula A Guerrero, Yoshiko Murakami, Ankita Malik, Peter H Seeberger, Taroh Kinoshita, Daniel Varón Silva

ACS chemical biology　Vol. 16　No. 11　p. 2297-2306　2021/11/19　Research paper (scientific journal)

Functional analysis of the gpi transamidase complex by screening for amino acid mutations in each subunit

Si Si Liu, Fei Jin, Yi Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita

Molecules　Vol. 26　No. 18　2021/09/01　Research paper (scientific journal)

CLPTM1L is a lipid scramblase involved in glycosylphosphatidylinositol biosynthesis

Yicheng Wang, Anant K. Menon, Yuta Maki, Yi-Shi Liu, Yugo Iwasaki, Morihisa Fujita, Paula A. Guerrero, Daniel Varón Silva, Peter H. Seeberger, Yoshiko Murakami, Taroh Kinoshita

bioRxiv　2021/07/14　Research paper (other academic)

Inherited glycosylphosphatidylinositol defects cause the rare Emm-negative blood phenotype and developmental disorders

Romain Duval, Gaël Nicolas, Alexandra Willemetz, Yoshiko Murakami, Mahmoud Mikdar, Cedric Vrignaud, Hisham Megahed, Jean Pierre Cartron, Cecile Masson, Samer Wehbi, Bérengere Koehl, Marie Hully, Karine Siquier, Nicole Chemlay, Agnes Rotig, Stanislas Lyonnet, Yves Colin, Giulia Barcia, Vincent Cantagrel, Caroline Le Van Kim, Olivier Hermine, Taroh Kinoshita, Thierry Peyrard, Slim Azouzi

Blood　Vol. 137　No. 26　p. 3660-3669　2021/07/01　Research paper (scientific journal)

Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals

Jing Yang, Tetsuya Hirata, Yi Shi Liu, Xin Yu Guo, Xiao Dong Gao, Taroh Kinoshita, Morihisa Fujita

FEBS Letters　Vol. 595　No. 11　p. 1542-1558　2021/06/01　Research paper (scientific journal)

A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins

Si Si Liu, Yi Shi Liu, Xin Yu Guo, Yoshiko Murakami, Ganglong Yang, Xiao Dong Gao, Taroh Kinoshita, Morihisa Fujita

Communications Biology　Vol. 4　No. 1　2021/06/01　Research paper (scientific journal)

PIGF deficiency causes a phenotype overlapping with DOORS syndrome

Smrithi Salian, Hind Benkerroum, Thi Tuyet Mai Nguyen, Sheela Nampoothiri, Taroh Kinoshita, Têmis Maria Félix, Fiona Stewart, Sanjay M. Sisodiya, Yoshiko Murakami, Philippe M. Campeau

Human Genetics　Vol. 140　No. 6　p. 879-884　2021/06/01　Research paper (scientific journal)

PIGO variants in a boy with features of Mabry syndrome who also exhibits Fryns syndrome with peripheral neuropathy

Taro Okuda, Takahiro Yonekawa, Yoshiko Murakami, Taroh Kinoshita, Takahiro Ito, Kohei Matsushita, Yuhki Koike, Mikihiro Inoue, Keiichi Uchida, Noriko Yodoya, Hiroyuki Ohashi, Hirofumi Sawada, Shotaro Iwamoto, Yoshihide Mitani, Masahiro Hirayama

American Journal of Medical Genetics, Part A　Vol. 185　No. 3　p. 845-849　2021/03/01　Research paper (scientific journal)

Early infancy-onset stimulation-induced myoclonic seizures in three siblings with inherited glycosylphosphatidylinositol (GPI) anchor deficiency

Yukiko Mogami, Yasuhiro Suzuki, Yoshiko Murakami, Tae Ikeda, Sadami Kimura, Keiko Yanagihara, Nobuhiko Okamoto, Taroh Kinoshita

Epileptic Disorders　Vol. 20　No. 1　p. 42-50　2021/02　Research paper (scientific journal)

Hrd1-dependent degradation of the unassembled pigk subunit of the gpi transamidase complex

Kohei Kawaguchi, Miki Yamamoto-Hino, Yoshiko Murakami, Taroh Kinoshita, Satoshi Goto

Cell Structure and Function　Vol. 46　No. 2　p. 65-71　2021　Research paper (scientific journal)

PIGG variant pathogenicity assessment reveals characteristic features within 19 families

Camille Tremblay-Laganière, Reza Maroofian, Thi Tuyet Mai Nguyen, Ehsan Ghayoor Karimiani, Salman Kirmani, Fizza Akbar, Shahnaz Ibrahim, Bushra Afroze, Mohammad Doosti, Farah Ashrafzadeh, Meisam Babaei, Stephanie Efthymiou, Marilena Christoforou, Tipu Sultan, Roger L. Ladda, Heather M. McLaughlin, Rebecca Truty, Sonal Mahida, Julie S. Cohen, Kristin Baranano, Fatima Y. Ismail, Millan S. Patel, Anna Lehman, Andrew C. Edmondson, Amanda Nagy, Melissa A. Walker, Saadet Mercimek-Andrews, Yuta Maki, Rani Sachdev, Rebecca Macintosh, Elizabeth E. Palmer, Grazia M.S. Mancini, Tahsin Stefan Barakat, Robert Steinfeld, Christina T. Rüsch, Georg M. Stettner, Matias Wagner, Saskia B. Wortmann, Usha Kini, Angela F. Brady, Karen L. Stals, Naila Ismayilova, Sian Ellard, Danilo Bernardo, Kimberly Nugent, Scott D. McLean, Stylianos E. Antonarakis, Henry Houlden, Taroh Kinoshita, Philippe M. Campeau, Yoshiko Murakami

Genetics in Medicine　Vol. 23　No. 10　p. 1873-1881　2021　Research paper (scientific journal)

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン 改訂2019年版

堀内 孝彦, 大澤 勲, 今井 優樹, 大谷 克城, 関根 英治, 塚本 浩, 中尾 実樹, 西村 純一, 水野 正司, 村上 良子, 山本 哲郎, 木下 タロウ, 大井 洋之, 井上 徳光, 若宮 伸隆, 野々山 恵章, 一般社団法人日本補体学会, 厚生労働省難治性疾患等政策研究事業「原発性免疫不全症候群の診断基準・重症度分類および診療ガイドラインの確立に関する研究」研究班

補体　Vol. 57　No. 1　p. 3-22　2020/12

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation

Yicheng Wang, Yusuke Maeda, Yi Shi Liu, Yoko Takada, Akinori Ninomiya, Tetsuya Hirata, Morihisa Fujita, Yoshiko Murakami, Taroh Kinoshita

Nature Communications　Vol. 11　No. 1　p. 860-860　2020/12/01　Research paper (scientific journal)

Calnexin mediates the maturation of GPI-anchors through ER retention

Xin Yu Guo, Yi Shi Liu, Xiao Dong Gao, Taroh Kinoshita, Morihisa Fujita

Journal of Biological Chemistry　Vol. 295　No. 48　p. 16393-16410　2020/11/27　Research paper (scientific journal)

Paroxysmal nocturnal hemoglobinuria caused by CN-LOH of constitutional PIGB mutation and 70-kbp microdeletion on 15q

Saskia Langemeijer, Charlotte Schaap, Frank Preijers, Joop H. Jansen, Nicole Blijlevens, Norimitsu Inoue, Petra Muus, Taroh Kinoshita, Yoshiko Murakami

Blood Advances　Vol. 4　No. 22　p. 5755-5761　2020/11/24　Research paper (scientific journal)

PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins

Gun Hee Lee, Morihisa Fujita, Hideki Nakanishi, Haruhiko Miyata, Masahito Ikawa, Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 295　No. 42　p. 14501-14509　2020/10/16　Research paper (scientific journal)

α2,3 linkage of sialic acid to a GPI anchor and an unpredicted GPI attachment site in human prion protein

Atsushi Kobayashi, Tetsuya Hirata, Takashi Nishikaze, Akinori Ninomiya, Yuta Maki, Yoko Takada, Tetsuyuki Kitamoto, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 295　No. 22　p. 7789-7798　2020/05/28　Research paper (scientific journal)

A post glycosylphosphatidylinositol (GPI) attachment to proteins, type 2 (PGAP2) variant identified in Mabry syndrome index cases: Molecular genetics of the prototypical inherited GPI disorder

Miles D. Thompson, Alexej A. Knaus, Bruce A. Barshop, Almuth Caliebe, Hiltrud Muhle, Thi Tuyet Mai Nguyen, Nissan V. Baratang, Taroh Kinoshita, Maire E. Percy, Philippe M. Campeau, Yoshiko Murakami, David E. Cole, Peter M. Krawitz, C. Charlton Mabry

European Journal of Medical Genetics　Vol. 63　No. 4　2020/04/01　Research paper (scientific journal)

Bi-allelic Variants in the GPI Transamidase Subunit PIGK Cause a Neurodevelopmental Syndrome with Hypotonia, Cerebellar Atrophy, and Epilepsy

Thi Tuyet Mai Nguyen, Yoshiko Murakami, Sabrina Mobilio, Marcello Niceta, Giuseppe Zampino, Christophe Philippe, Sébastien Moutton, Maha S. Zaki, Kiely N. James, Damir Musaev, Weiyi Mu, Kristin Baranano, Jessica R. Nance, Jill A. Rosenfeld, Nancy Braverman, Andrea Ciolfi, Francisca Millan, Richard E. Person, Ange Line Bruel, Christel Thauvin-Robinet, Athina Ververi, Catherine DeVile, Alison Male, Stephanie Efthymiou, Reza Maroofian, Henry Houlden, Shazia Maqbool, Fatima Rahman, Nissan V. Baratang, Justine Rousseau, Anik St-Denis, Matthew J. Elrick, Irina Anselm, Lance H. Rodan, Marco Tartaglia, Joseph Gleeson, Taroh Kinoshita, Philippe M. Campeau

American Journal of Human Genetics　Vol. 106　No. 4　p. 484-495　2020/04/01　Research paper (scientific journal)

Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation

Britta Höchsmann, Yoshiko Murakami, Makiko Osato, Alexej Knaus, Michi Kawamoto, Norimitsu Inoue, Tetsuya Hirata, Shogo Murata, Markus Anliker, Thomas Eggermann, Marten Jäger, Ricarda Floettmann, Alexander Höllein, Sho Murase, Yasutaka Ueda, Nishimura Jun-Ichi, Yuzuru Kanakura, Nobuo Kohara, Hubert Schrezenmeier, Peter M. Krawitz, Taroh Kinoshita

Journal of Clinical Investigation　Vol. 129　No. 12　p. 5123-5136　2019/12/02　Research paper (scientific journal)

Mutations in PIGB Cause an Inherited GPI Biosynthesis Defect with an Axonal Neuropathy and Metabolic Abnormality in Severe Cases

Yoshiko Murakami, Thi Tuyet Mai Nguyen, Nissan Baratang, Praveen K. Raju, Alexej Knaus, Sian Ellard, Gabriela Jones, B. Lace, Justine Rousseau, Norbert Fonya Ajeawung, Atsushi Kamei, Gaku Minase, Manami Akasaka, Nami Araya, E. Koshimizu, Jenneke van den Ende, Florian Erger, Janine Altmüller, Zita Krumina, Jurgis Strautmanis, Inna Inashkina, J. Stavusis, A. El-Gharbawy, Jessica Sebastian, Ratna Dua Puri, Samarth Kulshrestha, Ishwar C. Verma, Esther M. Maier, Tobias B. Haack, Anil Israni, J. Baptista, Adam Gunning, Jill A. Rosenfeld, Pengfei Liu, Marieke Joosten, María Eugenia Rocha, Mais O. Hashem, Hesham M. Aldhalaan, Fowzan S. Alkuraya, Satoko Miyatake, Naomichi Matsumoto, Peter M. Krawitz, Elsa Rossignol, T. Kinoshita, Philippe M. Campeau

American Journal of Human Genetics　Vol. 105　No. 2　p. 384-394　2019/08/01　Research paper (scientific journal)

Mutations in PIGU Impair the Function of the GPI Transamidase Complex, Causing Severe Intellectual Disability, Epilepsy, and Brain Anomalies

Alexej Knaus, F. Kortüm, Tjitske Kleefstra, Asbjørg Stray-Pedersen, D. Đukić, Yoshiko Murakami, Thorsten Gerstner, Hans van Bokhoven, Z. Iqbal, Denise Horn, T. Kinoshita, Maja Hempel, Peter M. Krawitz

American Journal of Human Genetics　Vol. 105　No. 2　p. 395-402　2019/08/01　Research paper (scientific journal)

Cerebellar neurodegeneration and neuronal circuit remodeling in golgi pH regulator-deficient mice

Yu Shin Sou, Soichiro Kakuta, Yuji Kamikubo, Kazue Niisato, Takashi Sakurai, Laxmi Kumar Parajuli, Isei Tanida, Hiromitsu Saito, Noboru Suzuki, Kenji Sakimura, Yusuke Maeda, Taroh Kinoshita, Yasuo Uchiyama, Masato Koike

eNeuro　Vol. 6　No. 3　p. 1-22　2019/05/01　Research paper (scientific journal)

Free, unlinked glycosylphosphatidylinositols on mammalian cell surfaces revisited

Yicheng Wang, Tetsuya Hirata, Yusuke Maeda, Yoshiko Murakami, Morihisa Fujita, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 294　No. 13　p. 5038-5049　2019/03/29　Research paper (scientific journal)

Glycans in infection and immunity

Takashi Suzuki, Masatoshi Okamatsu, Yoshihiro Sakoda, Taroh Kinoshita, Takane Katayama, Hiroshi Kiyono, Yoshiyuki Goto, Kaoru Takegawa, Naoaki Yokoyama, Yukari Fujimoto, Takashi Angata, Katsuki Ohtani, Nobutaka Wakamiya, Hisashi Arase, Shoko Nishihara, Yasuo Suda

Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG)　p. 227-257　2019/01/01　Part of collection (book)

Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain

Tetsuya Hirata, Sushil K. Mishra, Shota Nakamura, Kazunobu Saito, Daisuke Motooka, Yoko Takada, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda, Morihisa Fujita, Yoshiki Yamaguchi, Taroh Kinoshita

Nature Communications　Vol. 9　No. 1　p. 405-405　2018/12/01　Research paper (scientific journal)

Mutations in PIGS, Encoding a GPI Transamidase, Cause a Neurological Syndrome Ranging from Fetal Akinesia to Epileptic Encephalopathy

Thi Tuyet Mai Nguyen, Yoshiko Murakami, Kristen M. Wigby, Nissan V. Baratang, Justine Rousseau, Anik St-Denis, Jill A. Rosenfeld, Stephanie C. Laniewski, Julie Jones, Alejandro D. Iglesias, Marilyn C. Jones, Diane Masser-Frye, Angela E. Scheuerle, Denise L. Perry, Ryan J. Taft, Françoise Le Deist, Miles Thompson, Taroh Kinoshita, Philippe M. Campeau

American Journal of Human Genetics　Vol. 103　No. 4　p. 602-611　2018/10/04　Research paper (scientific journal)

Lipid moiety of glycosylphosphatidylinositol-anchored proteins contributes to the determination of their final destination in yeast

Takehiko Yoko-o, Mariko Umemura, Akiko Komatsuzaki, Kazutaka Ikeda, Daisuke Ichikawa, Kumiko Takase, Noriyuki Kanzawa, Kazunobu Saito, Taroh Kinoshita, Ryo Taguchi, Yoshifumi Jigami

Genes to Cells　Vol. 23　No. 10　p. 880-892　2018/10/01　Research paper (scientific journal)

Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila

Miki Yamamoto-Hino, Eri Katsumata, Emiko Suzuki, Yusuke Maeda, Taroh Kinoshita, Satoshi Goto

Journal of Cell Science　Vol. 131　No. 20　2018/10/01　Research paper (scientific journal)

Congenital Defects in the Expression of the Glycosylphosphatidylinositol-Anchored Complement Regulatory Proteins CD59 and Decay-Accelerating Factor

Taroh Kinoshita

Seminars in Hematology　Vol. 55　No. 3　p. 136-140　2018/07

A homozygous variant disrupting the PIGH start-codon is associated with developmental delay, epilepsy, and microcephaly

Alistair T. Pagnamenta, Yoshiko Murakami, Consuelo Anzilotti, Hannah Titheradge, Adam J. Oates, Jenny Morton, Taroh Kinoshita, Usha Kini, Jenny C. Taylor

Human Mutation　Vol. 39　No. 6　p. 822-826　2018/06　Research paper (scientific journal)

N-Glycan-dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing

Yi Shi Liu, Xin Yu Guo, Tetsuya Hirata, Yao Rong, Daisuke Motooka, Toshihiko Kitajima, Yoshiko Murakami, Xiao Dong Gao, Shota Nakamura, Taroh Kinoshita, Morihisa Fujita

Journal of Cell Biology　Vol. 217　No. 2　p. 585-599　2018/02/01　Research paper (scientific journal)

Recurrent aseptic meningitis with PIGT mutations: A novel pathogenesis of recurrent meningitis successfully treated by eculizumab

Michi Kawamoto, Yoshiko Murakami, Taroh Kinoshita, Nobuo Kohara

BMJ Case Reports　Vol. 2018　2018　Research paper (scientific journal)

Epileptic apnea in a patient with inherited glycosylphosphatidylinositol anchor deficiency and PIGT mutations

Kosuke Kohashi, Akihiko Ishiyama, Shota Yuasa, Tomomi Tanaka, Kazushi Miya, Yuichi Adachi, Noriko Sato, Hirotomo Saitsu, Chihiro Ohba, Naomichi Matsumoto, Yoshiko Murakami, Taroh Kinoshita, Kenji Sugai, Masayuki Sasaki

Brain and Development　Vol. 40　No. 1　p. 53-57　2018/01　Research paper (scientific journal)

Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia

Thi Tuyet Mai Nguyen, Yoshiko Murakami, Eamonn Sheridan, Sophie Ehresmann, Justine Rousseau, Anik St-Denis, Guoliang Chai, Norbert F. Ajeawung, Laura Fairbrother, Tyler Reimschisel, Alexandra Bateman, Elizabeth Berry-Kravis, Fan Xia, Jessica Tardif, David A. Parry, Clare V. Logan, Christine Diggle, Christopher P. Bennett, Louise Hattingh, Jill A. Rosenfeld, Michael Scott Perry, Michael J. Parker, Françoise Le Deist, Maha S. Zaki, Erika Ignatius, Pirjo Isohanni, Tuula Lönnqvist, Christopher J. Carroll, Colin A. Johnson, Joseph G. Gleeson, Taroh Kinoshita, Philippe M. Campeau

American Journal of Human Genetics　Vol. 101　No. 5　p. 856-865　2017/11/02　Research paper (scientific journal)

PIGT-PNH患者における自己炎症メカニズムの解明(その1) 患者検体からの検討

村田 祥吾, 村上 良子, 大里 真幸子, 植田 康敬, 西村 純一, 井上 徳光, 川本 未知, 幸原 伸夫, 木下 タロウ

補体　Vol. 54　No. 1　p. 40-41　2017/09

PIGT-PNH患者における自己炎症メカニズムの解明(その2) ヒト単球細胞株での解析

大里 真幸子, 村上 良子, 村田 祥吾, 植田 康敬, 西村 純一, 金倉 譲, 木下 タロウ

補体　Vol. 54　No. 1　p. 42-43　2017/09

Genome-wide screening uncovers the significance of N-sulfation of heparan sulfate as a host cell factor for chikungunya virus infection

Atsushi Tanaka, Uranan Tumkosit, Shota Nakamura, Daisuke Motooka, Natsuko Kishishita, Thongkoon Priengprom, Areerat Sa-ngasang, Taroh Kinoshita, Naokazu Takeda, Yusuke Maeda

Journal of Virology　Vol. 91　No. 13　2017/07/01　Research paper (scientific journal)

Phenotype–genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties

Junpei Tanigawa, Haruka Mimatsu, Seiji Mizuno, Nobuhiko Okamoto, Daisuke Fukushi, Koji Tominaga, Hiroyuki Kidokoro, Yukako Muramatsu, Eriko Nishi, Shota Nakamura, Daisuke Motooka, Noriko Nomura, Kiyoshi Hayasaka, Tetsuya Niihori, Yoko Aoki, Shin Nabatame, Masahiro Hayakawa, Jun Natsume, Keiichi Ozono, Taroh Kinoshita, Nobuaki Wakamatsu, Yoshiko Murakami

Human Mutation　Vol. 38　No. 7　p. 805-815　2017/07　Research paper (scientific journal)

Monkeypox virus host factor screen using haploid cells identifies essential role of GARP complex in extracellular virus formation

Susan Realegeno, Andreas S. Puschnik, Amrita Kumar, Cynthia Goldsmith, Jillybeth Burgado, Suryaprakash Sambhara, Victoria A. Olson, Darin Carroll, Inger Damon, Tetsuya Hirata, Taroh Kinoshita, Jan E. Carette, Panayampalli Subbian Satheshkumar

Journal of Virology　Vol. 91　No. 11　2017/06/01　Research paper (scientific journal)

Compound heterozygous mutations in the gene PIGP are associated with early infantile epileptic encephalopathy

Devon L. Johnstone, Thi Tuyet Mai Nguyen, Yoshiko Murakami, Kristin D. Kernohan, Martine Tétreault, Claire Goldsmith, Asif Doja, Justin D. Wagner, Lijia Huang, Taila Hartley, Anik St-Denis, Francoise Le Deist, Jacek Majewski, Dennis E. Bulman, Taroh Kinoshita, David A. Dyment, Kym M. Boycott, Philippe M. Campeau

Human Molecular Genetics　Vol. 26　No. 9　p. 1706-1715　2017/05/01　Research paper (scientific journal)

Analysis of exome data for 4293 trios suggests GPI-anchor biogenesis defects are a rare cause of developmental disorders

Alistair T. Pagnamenta, Yoshiko Murakami, John M. Taylor, Consuelo Anzilotti, Malcolm F. Howard, Venessa Miller, Diana S. Johnson, Shereen Tadros, Sahar Mansour, I. Karen Temple, Rachel Firth, Elisabeth Rosser, Rachel E. Harrison, Bronwen Kerr, Niko Popitsch, Taroh Kinoshita, Jenny C. Taylor, Usha Kini

European Journal of Human Genetics　Vol. 25　No. 6　p. 669-679　2017/03/22　Research paper (scientific journal)

Mutations in the phosphatidylinositol glycan C (PIGC) gene are associated with epilepsy and intellectual disability

Simon Edvardson, Yoshiko Murakami, Thi Tuyet Mai Nguyen, Maher Shahrour, Anik St-Denis, Avraham Shaag, Nadira Damseh, Françoise Le Deist, Yenan Bryceson, Bassam Abu-Libdeh, Philippe M Campeau, Taroh Kinoshita, Orly Elpeleg

Journal of Medical Genetics　Vol. 54　No. 3　p. 196-201　2017/03/01　Research paper (scientific journal)

Glycan region of GPI anchored-protein is required for cytocidal oligomerization of an anticancer parasporin-2, Cry46Aa1 protein, from Bacillus thuringiensis strain A1547

Yuich Abe, Hiroshi Inoue, Hisashi Ashida, Yusuke Maeda, Taroh Kinoshita, Sakae Kitada

Journal of Invertebrate Pathology　Vol. 142　p. 71-81　2017/01/01　Research paper (scientific journal)

A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia

Ana L. Kolicheski, Gary S. Johnson, Tendai Mhlanga-Mutangadura, Jeremy F. Taylor, Robert D. Schnabel, Taroh Kinoshita, Yoshiko Murakami, Dennis P. O’Brien

Neurogenetics　Vol. 18　No. 1　p. 39-47　2017/01/01　Research paper (scientific journal)

PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis

Shinji Ihara, Sohei Nakayama, Yoshiko Murakami, Emiko Suzuki, Masayo Asakawa, Taroh Kinoshita, Hitoshi Sawa

Journal of Cell Science　Vol. 130　No. 3　p. 602-613　2017　Research paper (scientific journal)

A novel mutation in PIGW causes glycosylphosphatidylinositol deficiency without hyperphosphatasia

Max Hogrebe, Yoshiko Murakami, Martin Wild, Martina Ahlmann, Saskia Biskup, Konstanze Hörtnagel, Marianne Grüneberg, Janine Reunert, Tobias Linden, Taroh Kinoshita, Thorsten Marquardt

American Journal of Medical Genetics, Part A　Vol. 170　No. 12　p. 3319-3322　2016/12/01　Research paper (scientific journal)

Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

Haruhiko Ninomiya, Naoshi Obara, Shigeru Chiba, Kensuke Usuki, Kaichi Nishiwaki, Itaru Matsumura, Tsutomu Shichishima, Shinichiro Okamoto, Jun ichi Nishimura, Kazuma Ohyashiki, Shinji Nakao, Kiyoshi Ando, Yoshinobu Kanda, Tatsuya Kawaguchi, Hideki Nakakuma, Daisuke Harada, Hirozumi Akiyama, Taroh Kinoshita, Keiya Ozawa, Mitsuhiro Omine, Yuzuru Kanakura

International Journal of Hematology　Vol. 104　No. 5　p. 548-558　2016/11/01　Research paper (scientific journal)

Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils

Hitoshi Nakayama, Hidetake Kurihara, Yasu S. Morita, Taroh Kinoshita, Laura Mauri, Alessandro Prinetti, Sandro Sonnino, Noriko Yokoyama, Hideoki Ogawa, Kenji Takamori, Kazuhisa Iwabuchi

Science Signaling　Vol. 9　No. 449　2016/10/11　Research paper (scientific journal)

3D Structure and Interaction of p24β and p24δ Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport

Masamichi Nagae, Tetsuya Hirata, Kana Morita-Matsumoto, Romina Theiler, Morihisa Fujita, Taroh Kinoshita, Yoshiki Yamaguchi

Journal of Molecular Biology　Vol. 428　No. 20　p. 4087-4099　2016/10/09　Research paper (scientific journal)

Rare Noncoding Mutations Extend the Mutational Spectrum in the PGAP3 Subtype of Hyperphosphatasia with Mental Retardation Syndrome

Alexej Knaus, Tomonari Awaya, Ingo Helbig, Zaid Afawi, Manuela Pendziwiat, Jubran Abu-Rachma, Miles D. Thompson, David E. Cole, Steve Skinner, Fran Annese, Natalie Canham, Michal R. Schweiger, Peter N. Robinson, Stefan Mundlos, Taroh Kinoshita, Arnold Munnich, Yoshiko Murakami, Denise Horn, Peter M. Krawitz

Human Mutation　Vol. 37　No. 8　p. 737-744　2016/08/01　Research paper (scientific journal)

Spatially distinct and metabolically active membrane domain in mycobacteria

Jennifer M. Hayashi, Chu Yuan Luo, Jacob A. Mayfield, Tsungda Hsu, Takeshi Fukuda, Andrew L. Walfield, Samantha R. Giffen, John D. Leszyk, Christina E. Baer, Owen T. Bennion, Ashoka Madduri, Scott A. Shaffer, Bree B. Aldridge, Christopher M. Sassetti, Steven J. Sandler, Taroh Kinoshita, D. Branch Moody, Yasu S. Morita

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 19　p. 5400-5405　2016/05/10　Research paper (scientific journal)

Pathogenic Variants in PIGG Cause Intellectual Disability with Seizures and Hypotonia

Periklis Makrythanasis, Mitsuhiro Kato, Maha S. Zaki, Hirotomo Saitsu, Kazuyuki Nakamura, Federico A. Santoni, Satoko Miyatake, Mitsuko Nakashima, Mahmoud Y. Issa, Michel Guipponi, Audrey Letourneau, Clare V. Logan, Nicola Roberts, David A. Parry, Colin A. Johnson, Naomichi Matsumoto, Hanan Hamamy, Eamonn Sheridan, Taroh Kinoshita, Stylianos E. Antonarakis, Yoshiko Murakami

American Journal of Human Genetics　Vol. 98　No. 4　p. 615-626　2016/04　Research paper (scientific journal)

A novel PIGN mutation and prenatal diagnosis of inherited glycosylphosphatidylinositol deficiency

Taku Nakagawa, Mariko Taniguchi-Ikeda, Yoshiko Murakami, Shota Nakamura, Daisuke Motooka, Tomomi Emoto, Wataru Satake, Masahiro Nishiyama, Daisaku Toyoshima, Naoya Morisada, Satoshi Takada, Shinya Tairaku, Nobuhiko Okamoto, Ichiro Morioka, Hiroki Kurahashi, Tatsushi Toda, Taroh Kinoshita, Kazumoto Iijima

American Journal of Medical Genetics, Part A　Vol. 170　No. 1　p. 183-188　2016/01/01　Research paper (scientific journal)

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO

Gun Hee Lee, Morihisa Fujita, Katsuyoshi Takaoka, Yoshiko Murakami, Yoshitaka Fujihara, Noriyuki Kanzawa, Kei Ichi Murakami, Eriko Kajikawa, Yoko Takada, Kazunobu Saito, Masahito Ikawa, Hiroshi Hamada, Yusuke Maeda, Taroh Kinoshita

Journal of Cell Biology　Vol. 215　No. 5　p. 705-718　2016　Research paper (scientific journal)

新規GPI切断酵素であるPGAP6はCRIPTOのnon-cell-autonomousなNodal副受容体機能を起こす

Lee Gun-Hee, 藤田 盛久, 高岡 勝吉, 村上 良子, 藤原 祥高, 伊川 正人, 濱田 博司, 前田 裕輔, 木下 タロウ

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 88回・38回　p. [2T特-04(2P0321)]　2015/12

Symbol nomenclature for graphical representations of glycans

Ajit Varki, Richard D. Cummings, Markus Aebi, Nicole H. Packer, Peter H. Seeberger, Jeffrey D. Esko, Pamela Stanley, Gerald Hart, Alan Darvill, Taroh Kinoshita, James J. Prestegard, Ronald L. Schnaar, Hudson H. Freeze, Jamey D. Marth, Carolyn R. Bertozzi, Marilynn E. Etzler, Martin Frank, Johannes F.G. Vliegenthart, Thomas Lütteke, Serge Perez, Evan Bolton, Pauline Rudd, James Paulson, Minoru Kanehisa, Philip Toukach, Kiyoko F. Aoki-Kinoshita, Anne Dell, Hisashi Narimatsu, William York, Naoyuki Taniguchi, Stuart Kornfeld

Glycobiology　Vol. 25　No. 12　p. 1323-1324　2015/12/01　Research paper (scientific journal)

Cerebral visual impairment and intellectual disability caused by PGAP1 variants

Daniëlle G.M. Bosch, F. Nienke Boonstra, Taroh Kinoshita, Shalini Jhangiani, Joep De Ligt, Frans P.M. Cremers, James R. Lupski, Yoshiko Murakami, Bert B.A. De Vries

European Journal of Human Genetics　Vol. 23　No. 12　p. 1689-1693　2015/12/01　Research paper (scientific journal)

Mutations in PIGY: Expanding the phenotype of inherited glycosylphosphatidylinositol deficiencies

Biljana Ilkovski, Alistair T. Pagnamenta, Gina L. O'Grady, Taroh Kinoshita, Malcolm F. Howard, Monkol Lek, Brett Thomas, Anne Turner, John Christodoulou, David Sillence, Samantha J.L. Knight, Niko Popitsch, David A. Keays, Consuelo Anzilotti, Anne Goriely, Leigh B. Waddel, Fabienne Brilot, Kathryn N. North, Noriyuki Kanzawa, Daniel G. Macarthur, Jenny C. Taylor, Usha Kini, Yoshiko Murakami, Nigel F. Clarke

Human Molecular Genetics　Vol. 24　No. 21　p. 6146-6159　2015/11/01　Research paper (scientific journal)

Genome-wide screening of genes required for glycosylphosphatidylinositol biosynthesis

Yao Rong, Shota Nakamura, Tetsuya Hirata, Daisuke Motooka, Yi Shi Liu, Zeng An He, Xiao Dong Gao, Yusuke Maeda, Taroh Kinoshita, Morihisa Fujita

PLoS ONE　Vol. 10　No. 9　2015/09/18　Research paper (scientific journal)

Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport

Tetsuya Hirata, Morihisa Fujita, Shota Nakamura, Kazuyoshi Gotoh, Daisuke Motooka, Yoshiko Murakami, Yusuke Maeda, Taroh Kinoshita

Molecular Biology of the Cell　Vol. 26　No. 17　p. 3071-3084　2015/09/01　Research paper (scientific journal)

【補体のすべて～機能から病態まで～】発作性夜間ヘモグロビン尿症と補体

植田 康敬, 西村 純一, 木下 タロウ

血液フロンティア　Vol. 25　No. 9　p. 1295-1305　2015/08

Inherited GPI deficiency; a new disease with intellectual disability and epilepsy

Yoshiko Murakami, Taroh Kinoshita

Nihon rinsho. Japanese journal of clinical medicine　Vol. 73　No. 7　p. 1227-1237　2015/07/01　Research paper (scientific journal)

Mutations in PIGL in a patient with Mabry syndrome

Ikuma Fujiwara, Yoshiko Murakami, Tetsuya Niihori, Junko Kanno, Akiko Hakoda, Osamu Sakamoto, Nobuhiko Okamoto, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Taroh Kinoshita, Shigeo Kure, Yoichi Matsubara, Yoko Aoki

American Journal of Medical Genetics, Part A　Vol. 167　No. 4　p. 777-785　2015/04　Research paper (scientific journal)

Congenital Disorders of Glycosylation: Glycosylphosphatidylinositol (gpi)-Related

Yoshiko Murakami, Taroh Kinoshita

Glycoscience: Biology and Medicine　p. 1229-1236　2015/01/01　Part of collection (book)

Inherited GPI deficiencies: A new disease with intellectual disability and epilepsy

Yoshiko Murakami, Taroh Kinoshita

No To Hattatsu　Vol. 47　No. 1　p. 5-13　2015/01/01　Research paper (scientific journal)

Structural changes of GPI anchor after its attachment to proteins: Functional significance

Taroh Kinoshita

Advances in Experimental Medicine and Biology　Vol. 842　p. 17-25　2015　Research paper (scientific journal)

遺伝性血管性浮腫(HAE)ガイドライン 改訂2014年版

堀内 孝彦, 大澤 勲, 岡田 秀親, 塚本 浩, 中尾 実樹, 木下 タロウ, 高橋 実, 野中 勝, 松下 操, 関根 英治, 山本 哲郎, 若宮 伸隆, 藤田 禎三, 瀬谷 司, 井上 徳光, 大井 洋之, 一般社団法人日本補体学会HAEガイドライン作成委員会

補体　Vol. 51　No. 2　p. 24-30　2014/12

Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells

Masahiro Tokunaga, Chikara Kokubu, Yusuke Maeda, Jun Sese, Kyoji Horie, Nakaba Sugimoto, Taroh Kinoshita, Kosuke Yusa, Junji Takeda

BMC Genomics　Vol. 15　No. 1　2014/11/24　Research paper (scientific journal)

Endosomes-to-TGN retrograde transport mediated by GARP is required for post-Golgi anterograde transport and glycosylation

Tetsuya Hirata, Morihisa Fujita, Shota Nakamura, Kazuyoshi Gotoh, Daisuke Motooka, Yoshiko Murakami, Yusuke Maeda, Taroh Kinoshita

2014/11　Research paper (international conference proceedings)

New insights into the functions of PIGF, a protein involved in the ethanolamine phosphate transfer steps of glycosylphosphatidylinositol biosynthesis

Matthew J. Stokes, Yoshiko Murakami, Yusuke Maeda, Taroh Kinoshita, Yasu S. Morita

Biochemical Journal　Vol. 463　No. 2　p. 249-256　2014/10/15　Research paper (scientific journal)

Novel compound heterozygous PIGT mutations caused multiple congenital anomalies-hypotonia-seizures syndrome 3

Mitsuko Nakashima, Hirofumi Kashii, Yoshiko Murakami, Mitsuhiro Kato, Yoshinori Tsurusaki, Noriko Miyake, Masaya Kubota, Taroh Kinoshita, Hirotomo Saitsu, Naomichi Matsumoto

Neurogenetics　Vol. 15　No. 3　p. 193-200　2014/08　Research paper (scientific journal)

Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis

Hilary C. Martin, Grace E. Kim, Alistair T. Pagnamenta, Yoshiko Murakami, Gemma L. Carvill, Esther Meyer, Richard R. Copley, Andrew Rimmer, Giulia Barcia, Matthew R. Fleming, Jack Kronengold, Maile R. Brown, Karl A. Hudspith, John Broxholme, Alexander Kanapin, Jean Baptiste Cazier, Taroh Kinoshita, Rima Nabbout, David Bentley, Gil McVean, Sinéad Heavin, Zenobia Zaiwalla, Tony McShane, Heather C. Mefford, Deborah Shears, Helen Stewart, Manju A. Kurian, Ingrid E. Scheffer, Edward Blair, Peter Donnelly, Leonard K. Kaczmarek, Jenny C. Taylor

Human Molecular Genetics　Vol. 23　No. 12　p. 3200-3211　2014/06/15　Research paper (scientific journal)

The α-helical region in p24γ<inf>2</inf> subunit of p24 protein cargo receptor is pivotal for the recognition and transport of glycosylphosphatidylinositol-anchored proteins

Romina Theiler, Morihisa Fujita, Masamichi Nagae, Yoshiki Yamaguchi, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 289　No. 24　p. 16835-16843　2014/06/13　Research paper (scientific journal)

PIGA mutations cause early-onset epileptic encephalopathies and distinctive features

Mitsuhiro Kato, Hirotomo Saitsu, Yoshiko Murakami, Kenjiro Kikuchi, Shuei Watanabe, Mizue Iai, Kazushi Miya, Ryuki Matsuura, Rumiko Takayama, Chihiro Ohba, Mitsuko Nakashima, Yoshinori Tsurusaki, Noriko Miyake, Shin Ichiro Hamano, Hitoshi Osaka, Kiyoshi Hayasaka, Taroh Kinoshita, Naomichi Matsumoto

Neurology　Vol. 82　No. 18　p. 1587-1596　2014/05/06　Research paper (scientific journal)

Erratum to: PIGN mutations cause congenital anomalies, developmental delay, hypotonia, epilepsy, and progressive cerebellar atrophy (neurogenetics, DOI:10.1007/s10048-013-0384-7)

Chihiro Ohba, Nobuhiko Okamoto, Yoshiko Murakami, Yasuhiro Suzuki, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Fumiaki Tanaka, Taroh Kinoshita, Naomichi Matsumoto, Hirotomo Saitsu

Neurogenetics　Vol. 15　No. 2　2014/05/01　Research paper (scientific journal)

Paroxysmal nocturnal hemoglobinuria with copy number-neutral 6pLOH in GPI (+) but not in GPI (-) granulocytes

Yasutaka Ueda, Jun Ichi Nishimura, Yoshiko Murakami, Sachiko Kajigaya, Taroh Kinoshita, Yuzuru Kanakura, Neal S. Young

European Journal of Haematology　Vol. 92　No. 5　p. 450-453　2014/05　Research paper (scientific journal)

Null Mutation in PGAP1 Impairing Gpi-Anchor Maturation in Patients with Intellectual Disability and Encephalopathy

Yoshiko Murakami, Hasan Tawamie, Yusuke Maeda, Christian Büttner, Rebecca Buchert, Farah Radwan, Stefanie Schaffer, Heinrich Sticht, Michael Aigner, André Reis, Taroh Kinoshita, Rami Abou Jamra

PLoS Genetics　Vol. 10　No. 5　2014/05　Research paper (scientific journal)

PIGN mutations cause congenital anomalies, developmental delay, hypotonia, epilepsy, and progressive cerebellar atrophy

Chihiro Ohba, Nobuhiko Okamoto, Yoshiko Murakami, Yasuhiro Suzuki, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Fumiaki Tanaka, Taroh Kinoshita, Naomichi Matsumoto, Hirotomo Saitsu

Neurogenetics　Vol. 15　No. 2　p. 85-92　2014/05　Research paper (scientific journal)

Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation

Malcolm F. Howard, Yoshiko Murakami, Alistair T. Pagnamenta, Cornelia Daumer-Haas, Björn Fischer, Jochen Hecht, David A. Keays, Samantha J.L. Knight, Uwe Kölsch, Ulrike Krüger, Steffen Leiz, Yusuke Maeda, Daphne Mitchell, Stefan Mundlos, John A. Phillips, Peter N. Robinson, Usha Kini, Jenny C. Taylor, Denise Horn, Taroh Kinoshita, Peter M. Krawitz

American Journal of Human Genetics　Vol. 94　No. 2　p. 278-287　2014/02/06　Research paper (scientific journal)

PIGO mutations in intractable epilepsy and severe developmental delay with mild elevation of alkaline phosphatase levels

Kazuyuki Nakamura, Hitoshi Osaka, Yoshiko Murakami, Rie Anzai, Kiyomi Nishiyama, Hirofumi Kodera, Mitsuko Nakashima, Yoshinori Tsurusaki, Noriko Miyake, Taroh Kinoshita, Naomichi Matsumoto, Hirotomo Saitsu

Epilepsia　Vol. 55　No. 2　p. E13-E17　2014/02　Research paper (scientific journal)

GPI mannose extension (PIGM, PIGV, PIGB, PIGZ)

Taroh Kinoshita, Norimitsu Inoue

Handbook of Glycosyltransferases and Related Genes, Second Edition　Vol. 2　p. 1209-1220　2014/01/01　Part of collection (book)

Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GlcNAc transferase): A complex comprised of PIGA, PIGC, PIGH, PIGQ, PIGP, PIGY and DPM2

Taroh Kinoshita, Norimitsu Inoue, Yoshiko Murakami

Handbook of Glycosyltransferases and Related Genes, Second Edition　Vol. 2　p. 1193-1208　2014/01/01　Part of collection (book)

Genetic variants in C5 and poor response to eculizumab

Jun Ichi Nishimura, Masaki Yamamoto, Shin Hayashi, Kazuma Ohyashiki, Kiyoshi Ando, Andres L. Brodsky, Hideyoshi Noji, Kunio Kitamura, Tetsuya Eto, Toru Takahashi, Masayoshi Masuko, Takuro Matsumoto, Yuji Wano, Tsutomu Shichishima, Hirohiko Shibayama, Masakazu Hase, Lan Li, Krista Johnson, Alberto Lazarowski, Paul Tamburini, Johji Inazawa, Taroh Kinoshita, Yuzuru Kanakura

New England Journal of Medicine　Vol. 370　No. 7　p. 632-639　2014　Research paper (scientific journal)

Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome

Tomohiro Chiyonobu, Norimitsu Inoue, Masafumi Morimoto, Taroh Kinoshita, Yoshiko Murakami

Journal of Medical Genetics　Vol. 51　No. 3　p. 203-207　2014　Research paper (scientific journal)

Vitamin B6-responsive epilepsy due to inherited GPI deficiencyichiro

Ichiro Kuki, Yukitoshi Takahashi, Shin Okazaki, Hisashi Kawawaki, Eiji Ehara, Norimitsu Inoue, Taroh Kinoshita, Yoshiko Murakami

Neurology　Vol. 81　No. 16　p. 1467-1469　2013/10/15

Long-term efficacy and safety of eculizumab in Japanese patients with PNH: AEGIS trial

Yuzuru Kanakura, Kazuma Ohyashiki, Tsutomu Shichishima, Shinichiro Okamoto, Kiyoshi Ando, Haruhiko Ninomiya, Tatsuya Kawaguchi, Shinji Nakao, Hideki Nakakuma, Jun Ichi Nishimura, Taroh Kinoshita, Camille L. Bedrosian, Keiya Ozawa, Mitsuhiro Omine

International Journal of Hematology　Vol. 98　No. 4　p. 406-416　2013/10　Research paper (scientific journal)

Glycosylphosphatidylinositol mannosyltransferase II is the rate-limiting enzyme in glycosylphosphatidylinositol biosynthesis under limited dolichol-phosphate mannose availability

Tetsuya Hirata, Morihisa Fujita, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda, Taroh Kinoshita

Journal of Biochemistry　Vol. 154　No. 3　p. 257-264　2013/09　Research paper (scientific journal)

Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity

Yetao Wang, Yoshiko Murakami, Teruhito Yasui, Shigeharu Wakana, Hitoshi Kikutani, Taroh Kinoshita, Yusuke Maeda

Journal of Biological Chemistry　Vol. 288　No. 35　p. 25490-25499　2013/08/30　Research paper (scientific journal)

A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT

Peter M. Krawitz, Britta Höchsmann, Yoshiko Murakami, Britta Teubner, Ulrike Krüger, Eva Klopocki, Heidemarie Neitzel, Alexander Hoellein, Christina Schneider, Dmitri Parkhomchuk, Jochen Hecht, Peter N. Robinson, Stefan Mundlos, Taroh Kinoshita, Hubert Schrezenmeier

Blood　Vol. 122　No. 7　p. 1312-1315　2013/08/15　Research paper (scientific journal)

C5遺伝子多型によるPNH治療薬エクリズマブに対する不応性の解析

西村 純一, 山本 正樹, 大屋敷 一馬, 安藤 潔, 長谷 昌知, 柴山 浩彦, 稲澤 譲治, 木下 タロウ, 金倉 譲

補体シンポジウム講演集　Vol. 50　p. 44-45　2013/07

Implications of lipid moiety in oligomerization and immunoreactivities of GPI-Anchored proteins

Jihyoun Seong, Yetao Wang, Taroh Kinoshita, Yusuke Maeda

Journal of Lipid Research　Vol. 54　No. 4　p. 1077-1091　2013/04　Research paper (scientific journal)

PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndrome

Peter M. Krawitz, Yoshiko Murakami, Angelika Rieß, Marja Hietala, Ulrike Krüger, Na Zhu, Taroh Kinoshita, Stefan Mundlos, Jochen Hecht, Peter N. Robinson, Denise Horn

American Journal of Human Genetics　Vol. 92　No. 4　p. 584-589　2013/04　Research paper (scientific journal)

Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability

Lars Hansen, Hasan Tawamie, Yoshiko Murakami, Yuan Mang, Shoaib Ur Rehman, Rebecca Buchert, Stefanie Schaffer, Safia Muhammad, Mads Bak, Markus M. Nöthen, Eric P. Bennett, Yusuke Maeda, Michael Aigner, André Reis, Taroh Kinoshita, Niels Tommerup, Shahid Mahmood Baig, Rami Abou Jamra

American Journal of Human Genetics　Vol. 92　No. 4　p. 575-583　2013/04　Research paper (scientific journal)

本邦固有のC5遺伝子多型によるPNH治療薬エクリズマブに対する不応性

山本 正樹, 西村 純一, 大屋敷 一馬, 安藤 潔, 長谷 昌知, 柴山 浩彦, 稲澤 譲治, 木下 タロウ, 金倉 譲

日本内科学会雑誌　Vol. 102　No. Suppl.　p. 185-185　2013/02

Occupancy of whole blood cells by a single PIGA-mutant clone with HMGA2 amplification in a paroxysmal nocturnal haemoglobinuria patient having blood cells with NKG2D ligands

Nobuyoshi Hanaoka, Yoshiko Murakami, Masahide Nagata, Kentaro Horikawa, Shoichi Nagakura, Yuji Yonemura, Shogo Murata, Takashi Sonoki, Taroh Kinoshita, Hideki Nakakuma

British Journal of Haematology　Vol. 160　No. 1　p. 114-116　2013/01

Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis

Takeshi Fukuda, Takayuki Matsumura, Manabu Ato, Maho Hamasaki, Yukiko Nishiuchi, Yoshiko Murakami, Yusuke Maeda, Tamotsu Yoshimori, Sohkichi Matsumoto, Kazuo Kobayashi, Taroh Kinoshita, Yasu S. Morita

mBio　Vol. 4　No. 1　p. e00472-e00412　2013　Research paper (scientific journal)

Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels

Ursula Loizides-Mangold, Fabrice P.A. David, Victor J. Nesatyy, Taroh Kinoshita, Howard Riezman

Journal of Lipid Research　Vol. 53　No. 8　p. 1522-1534　2012/08　Research paper (scientific journal)

GPHR-dependent functions of the golgi apparatus are essential for the formation of lamellar granules and the skin barrier

Masahito Tarutani, Kimiko Nakajima, Yoshikazu Uchida, Mikiro Takaishi, Naoko Goto-Inoue, Masahito Ikawa, Mitsutoshi Setou, Taroh Kinoshita, Peter M. Elias, Shigetoshi Sano, Yusuke Maeda

Journal of Investigative Dermatology　Vol. 132　No. 8　p. 2019-2025　2012/08　Research paper (scientific journal)

Mutations in PIGO, a member of the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation

Peter M. Krawitz, Yoshiko Murakami, Jochen Hecht, Ulrike Krüger, Susan E. Holder, Geert R. Mortier, Barbara Delle Chiaie, Elfride De Baere, Miles D. Thompson, Tony Roscioli, Szymon Kielbasa, Taroh Kinoshita, Stefan Mundlos, Peter N. Robinson, Denise Horn

American Journal of Human Genetics　Vol. 91　No. 1　p. 146-151　2012/07/13　Research paper (scientific journal)

Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome,and rhizomelic chondrodysplasia punctata

Noriyuki Kanzawa, Nobuyuki Shimozawa, Ronald J.A. Wanders, Kazutaka Ikeda, Yoshiko Murakami, Hans R. Waterham, Satoru Mukai, Morihisa Fujita, Yusuke Maeda, Ryo Taguchi, Yukio Fujiki, Taroh Kinoshita

Journal of Lipid Research　Vol. 53　No. 4　p. 653-663　2012/04　Research paper (scientific journal)

Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia mental retardation syndrome

Yoshiko Murakami, Noriyuki Kanzawa, Kazunobu Saito, Peter M. Krawitz, Stefan Mundlos, Peter N. Robinson, Anastasios Karadimitris, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 287　No. 9　p. 6318-6325　2012/02/24　Research paper (scientific journal)

Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria

Yoshiko Murakami, Norimitsu Inoue, Tsutomu Shichishima, Rieko Ohta, Hideyoshi Noji, Yusuke Maeda, Jun ichi Nishimura, Yuzuru Kanakura, Taroh Kinoshita

British Journal of Haematology　Vol. 156　No. 3　p. 383-387　2012/02　Research paper (scientific journal)

Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins

Hidekazu Murakami, Yetao Wang, Hidetoshi Hasuwa, Yusuke Maeda, Taroh Kinoshita, Yoshiko Murakami

Biochemical and Biophysical Research Communications　Vol. 417　No. 4　p. 1235-1241　2012/01/27　Research paper (scientific journal)

Identification of a second catalytically active trans-sialidase in Trypanosoma brucei

Fumiki Nakatani, Yasu S. Morita, Hisashi Ashida, Kisaburo Nagamune, Yusuke Maeda, Taroh Kinoshita

Biochemical and Biophysical Research Communications　Vol. 415　No. 2　p. 421-425　2011/11/18　Research paper (scientific journal)

Impaired FcεRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins

Wouter L.W. Hazenbos, Ping Wu, Jeffrey Eastham-Anderson, Taroh Kinoshita, Eric J. Brown

Blood　Vol. 118　No. 16　p. 4377-4383　2011/10/20　Research paper (scientific journal)

Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI

Morihisa Fujita, Reika Watanabe, Nina Jaensch, Maria Romanova-Michaelides, Tadashi Satoh, Masaki Kato, Howard Riezman, Yoshiki Yamaguchi, Yusuke Maeda, Taroh Kinoshita

Journal of Cell Biology　Vol. 194　No. 1　p. 61-75　2011/07/11　Research paper (scientific journal)

Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: The AEGIS Clinical Trial

Yuzuru Kanakura, Kazuma Ohyashiki, Tsutomu Shichishima, Shinichiro Okamoto, Kiyoshi Ando, Haruhiko Ninomiya, Tatsuya Kawaguchi, Shinji Nakao, Hideki Nakakuma, Jun Ichi Nishimura, Taroh Kinoshita, Camille L. Bedrosian, Marye Ellen Valentine, Gus Khursigara, Keiya Ozawa, Mitsuhiro Omine

International Journal of Hematology　Vol. 93　No. 1　p. 36-46　2011/01　Research paper (scientific journal)

Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome

Peter M. Krawitz, Michal R. Schweiger, Christian Rödelsperger, Carlo Marcelis, Uwe Kölsch, Christian Meisel, Friederike Stephani, Taroh Kinoshita, Yoshiko Murakami, Sebastian Bauer, Melanie Isau, Axel Fischer, Andreas Dahl, Martin Kerick, Jochen Hecht, Sebastian Köhler, Marten Jäger, Johannes Grünhagen, Birgit Jonske De Condor, Sandra Doelken, Han G. Brunner, Peter Meinecke, Eberhard Passarge, Miles D. Thompson, David E. Cole, Denise Horn, Tony Roscioli, Stefan Mundlos, Peter N. Robinson

Nature Genetics　Vol. 42　No. 10　p. 827-829　2010/10　Research paper (scientific journal)

Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria

Yasu S. Morita, Yoshiki Yamaryo-Botte, Kana Miyanagi, Judy M. Callaghan, John H. Patterson, Paul K. Crellin, Ross L. Coppel, Helen Billman-Jacobe, Taroh Kinoshita, Malcolm J. McConville

Journal of Biological Chemistry　Vol. 285　No. 22　p. 16643-16650　2010/05/28　Research paper (scientific journal)

Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish rohon-beard neurons to respond to mechanosensory stimulation

Yuri Nakano, Morihisa Fujita, Kazutoyo Ogino, Louis Saint-Amant, Taroh Kinoshita, Yoichi Oda, Hiromi Hirata

Development　Vol. 137　No. 10　p. 1689-1698　2010/05/15　Research paper (scientific journal)

Acquisition of complement resistance through incorporation of CD55/decay-accelerating factor into viral particles bearing baculovirus GP64

Yuuki Kaname, Hideki Tani, Chikako Kataoka, Mai Shiokawa, Shuhei Taguwa, Takayuki Abe, Kohji Moriishi, Taroh Kinoshita, Yoshiharu Matsuura

Journal of Virology　Vol. 84　No. 7　p. 3210-3219　2010/04　Research paper (scientific journal)

Controlled expression of branch-forming mannosyltransferase is critical for mycobacterial lipoarabinomannan biosynthesis

Chubert B.C. Sena, Takeshi Fukuda, Kana Miyanagi, Sohkichi Matsumoto, Kazuo Kobayashi, Yoshiko Murakami, Yusuke Maeda, Taroh Kinoshita, Yasu S. Morita

Journal of Biological Chemistry　Vol. 285　No. 18　p. 13326-13336　2010/04　Research paper (scientific journal)

GPI-Anchor: Update for Biosynthesis and Remodeling

Yusuke Maeda, Morihisa Fujita, Taroh Kinoshita

Trends in Glycoscience and Glycotechnology　Vol. 22　No. 126　p. 182-193　2010　Research paper (scientific journal)

The acidic environment of the golgi is critical for glycosylation and transport

Yusuke Maeda, Taroh Kinoshita

Methods in Enzymology　Vol. 480　No. C　p. 495-510　2010　Part of collection (book)

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki

Journal of Experimental Medicine　Vol. 206　No. 13　p. 2879-2888　2009/12/21　Research paper (scientific journal)

Peroxisome dependency of alkyl-containing GPI-anchor biosynthesis in the endoplasmic reticulum

Noriyuki Kanzawa, Yusuke Maeda, Hideo Ogiso, Yoshiko Murakami, Ryo Taguchi, Taroh Kinoshita

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 42　p. 17711-17716　2009/10/20　Research paper (scientific journal)

GPI Glycan Remodeling by PGAP5 Regulates Transport of GPI-Anchored Proteins from the ER to the Golgi

Morihisa Fujita, Yusuke Maeda, Moonjin Ra, Yoshiki Yamaguchi, Ryo Taguchi, Taroh Kinoshita

Cell　Vol. 139　No. 2　p. 352-365　2009/10/16　Research paper (scientific journal)

Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice

Shin Ichiro Honda, Naoki Kurita, Akitomo Miyamoto, Yukiko Cho, Kenta Usui, Kie Takeshita, Satoru Takahashi, Teruhito Yasui, Hitoshi Kikutani, Taroh Kinoshita, Teizo Fujita, Satoko Tahara-Hanaoka, Kazuko Shibuya, Akira Shibuya

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 27　p. 11230-11235　2009/07/07　Research paper (scientific journal)

[Host-pathogen interactions: parasites].

Taroh Kinoshita

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 54　No. 8 Suppl　p. 1027-1028　2009/06　Research paper (scientific journal)

Testicular angiotensin-converting enzyme with different glycan modification: Characterization on glycosylphosphatidylinositol-anchored protein releasing and dipeptidase activities

Gen Kondoh, Hitomi Watanabe, Yuko Tashima, Yusuke Maeda, Taroh Kinoshita

Journal of Biochemistry　Vol. 145　No. 1　p. 115-121　2009/01　Research paper (scientific journal)

Integrin-linked kinase associated with integrin activation

Shigenori Honda, Hiroko Shirotani-Ikejima, Seiji Tadokoro, Yusuke Maeda, Taroh Kinoshita, Yoshiaki Tomiyama, Toshiyuki Miyata

Blood　Vol. 113　No. 21　p. 5304-5313　2009　Research paper (scientific journal)

Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis

Ce Tang, Hisakata Yamada, Kensuke Shibata, Naoyoshi Maeda, Shinichi Yoshida, Worawidh Wajjwalku, Naoya Ohara, Takeshi Yamada, Taroh Kinoshita, Yasunobu Yoshikai

Journal of Infectious Diseases　Vol. 197　No. 9　p. 1263-1274　2008/05/01　Research paper (scientific journal)

Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane

Satoshi Takida, Yusuke Maeda, Taroh Kinoshita

Biochemical Journal　Vol. 409　No. 2　p. 555-562　2008/01/15　Research paper (scientific journal)

Association of dengue virus NS1 protein with lipid rafts

Sansanee Noisakran, Thanyaporn Dechtawewat, Panisadee Avirutnan, Taroh Kinoshita, Uamporn Siripanyaphinyo, Chunya Puttikhunt, Watchara Kasinrerk, Prida Malasit, Nopporn Sittisombut

Journal of General Virology　Vol. 89　No. 10　p. 2492-2500　2008　Research paper (scientific journal)

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

Yusuke Maeda, Toru Ide, Masato Koike, Yasuo Uchiyama, Taroh Kinoshita

Nature Cell Biology　Vol. 10　No. 10　p. 1135-1145　2008　Research paper (scientific journal)

PGAP1 knock-out mice show otocephaly and male infertility

Yasutaka Ueda, Ryo Yamaguchi, Masahito Ikawa, Masaru Okabe, Eiichi Morii, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 282　No. 42　p. 30373-30380　2007/10/19　Research paper (scientific journal)

Changes in molecular species profiles of glycosylphosphatidylinositol anchor precursors in early stages of biosynthesis

Toshiaki Houjou, Jun Hayakawa, Reika Watanabe, Yuko Tashima, Yusuke Maeda, Taroh Kinoshita, Ryo Taguchi

Journal of Lipid Research　Vol. 48　No. 7　p. 1599-1606　2007/07　Research paper (scientific journal)

Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast

Youn Uck Kim, Hisashi Ashida, Kenichiro Mori, Yusuke Maeda, Yeongjin Hong, Taroh Kinoshita

Journal of Biochemistry　Vol. 142　No. 1　p. 123-129　2007/07　Research paper (scientific journal)

Glycolipids with nonreducing end α-mannosyl residues that have the potential to activate invariant Vα19 NKT cells

Michio Shimamura, Yi Ying Huang, Naoki Okamoto, Yutaka Watanabe, Yoshiko Murakami, Taroh Kinoshita, Yoshio Hirabayashi, Chikara Murakata, Yukishige Ito, Tomoya Ogawa

FEBS Journal　Vol. 274　No. 11　p. 2921-2932　2007/06　Research paper (scientific journal)

Fatty acid remodeling of GPI-anchored proteins is required for their raft association

Yusuke Maeda, Yuko Tashima, Toshiaki Houjou, Morihisa Fujita, Takehiko Yoko-o, Yoshifumi Jigami, Ryo Taguchi, Taroh Kinoshita

Molecular Biology of the Cell　Vol. 18　No. 4　p. 1497-1506　2007/04　Research paper (scientific journal)

Targeted therapy for inherited GPI deficiency

Antonio M. Almeida, Yoshiko Murakami, Alastair Baker, Yusuke Maeda, Irene A.G. Roberts, Taroh Kinoshita, D. Mark Layton, Anastasios Karadimitris

New England Journal of Medicine　Vol. 356　No. 16　p. 1641-1647　2007/04　Research paper (scientific journal)

Diseases Associated with GPI Anchors

T. Kinoshita, Y. Murakami, Y. S. Morita

Comprehensive Glycoscience: From Chemistry to Systems Biology　Vol. 4-4　p. 393-419　2007/01/01　Part of collection (book)

Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)

Norimitsu Inoue, Tomohisa Izui-Sarumaru, Yoshiko Murakami, Yuichi Endo, Jun Ichi Nishimura, Ken Kurokawa, Maki Kuwayama, Hiroaki Shime, Takashi Machii, Yuzuru Kanakura, Gabrielle Meyers, Carl Wittwer, Zhong Chen, William Babcock, Debra Frei-Lahr, Charles J. Parker, Taroh Kinoshita

Blood　Vol. 108　No. 13　p. 4232-4236　2006/12/15　Research paper (scientific journal)

Isolation of new CHO cell mutants defective in CMP-sialic acid biosynthesis and transport

Dong Jun Shin, Ji Young Kang, Youn Uck Kim, Joong Sik Yoon, Hyon E. Choy, Yusuke Maeda, Taroh Kinoshita, Yeongjin Hong

Molecules and Cells　Vol. 22　No. 3　p. 343-352　2006/12　Research paper (scientific journal)

PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria

Yasu S. Morita, Chubert B.C. Sena, Ross F. Waller, Ken Kurokawa, M. Fleur Sernee, Fumiki Nakatani, Ruth E. Haites, Helen Billman-Jacobe, Malcolm J. McConville, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 281　No. 35　p. 25143-25155　2006/09/01　Research paper (scientific journal)

Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency

Antonio M. Almeida, Yoshiko Murakami, D. Mark Layton, Peter Hillmen, Gabrielle S. Sellick, Yusuke Maeda, Stephen Richards, Scott Patterson, Ioannis Kotsianidis, Luigina Mollica, Dorothy H. Crawford, Alastair Baker, Michael Ferguson, Irene Roberts, Richard Houlston, Taroh Kinoshita, Anastasios Karadimitris

Nature Medicine　Vol. 12　No. 7　p. 846-851　2006/07　Research paper (scientific journal)

A cohort study of the nature of paroxysmal nocturnal hemoglobinuria clones and PIG-A mutations in patients with aplastic anemia

Wanchai Wanachiwanawin, Uamporn Siripanyaphinyo, Nattawan Piyawattanasakul, Taroh Kinoshita

European Journal of Haematology　Vol. 76　No. 6　p. 502-509　2006/06　Research paper (scientific journal)

Removal or maintenance of inositol-linked acyl chain in glycosylphosphatidylinositol is critical in trypanosome life cycle

Yeonchul Hong, Kisaburo Nagamune, Yasu S. Morita, Fumiki Nakatani, Hisashi Ashida, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 281　No. 17　p. 11595-11602　2006/04　Research paper (scientific journal)

PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins

Yuko Tashima, Ryo Taguchi, Chie Murata, Hisashi Ashida, Taroh Kinoshita, Yusuke Maeda

Molecular Biology of the Cell　Vol. 17　No. 3　p. 1410-1420　2006/03　Research paper (scientific journal)

TbGPI16 is an essential component of GPI transamidase in Trypanosoma brucei

Yeonchul Hong, Kisaburo Nagamune, Kazuhito Ohishi, Yasu S. Morita, Hisashi Ashida, Yusuke Maeda, Taroh Kinoshita

FEBS Letters　Vol. 580　No. 2　p. 603-606　2006/01/23　Research paper (scientific journal)

DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3

Hisashi Ashida, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 281　No. 2　p. 896-904　2006/01/13　Research paper (scientific journal)

Erratum: Kola acuminata proanthocyanidins: A class of anti-trypanosomal compounds effective against Trypanosoma brucei (International Journal for Parasitology (2005) 35 (91-103) DOI: 10.1016/j.ijpara.2004.10.019)

B. K. Kubata, Kisaburo Nagamune, Nobutoshi Murakami, Patrick Merkel, Zakayi Kabututu, Samuel K. Martin, Taba M. Kalulu, Mostaqul Huq, Mitsuru Yoshida, Mayumi Ohnishi-Kameyama, Taroh Kinoshita, Michael Duszenko, Yoshihiro Urade

International Journal for Parasitology　Vol. 35　No. 14　2005/12　Research paper (scientific journal)

The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component

Yoshiko Murakami, Uamporn Siripanyaphinyo, Yeongjin Hong, Yuko Tashima, Yusuke Maeda, Taroh Kinoshita

Molecular Biology of the Cell　Vol. 16　No. 11　p. 5236-5246　2005/11　Research paper (scientific journal)

New mutant Chinese hamster ovary cell representing an unknown gene for attachment of glycosylphosphatidylinositol to proteins

Yeongjin Hong, Ji Young Kang, Youn Uck Kim, Dong Jun Shin, Hyon E. Choy, Yusuke Maeda, Taroh Kinoshita

Biochemical and Biophysical Research Communications　Vol. 335　No. 4　p. 1060-1069　2005/10/07　Research paper (scientific journal)

Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system

Vincent W. Keng, Kojiro Yae, Tomoko Hayakawa, Sumi Mizuno, Yoshihiro Uno, Kosuke Yusa, Chikara Kokubu, Taroh Kinoshita, Keiko Akagi, Nancy A. Jenkins, Neal G. Copeland, Kyoji Horie, Junji Takeda

Nature Methods　Vol. 2　No. 10　p. 763-769　2005/10　Research paper (scientific journal)

PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol

Young Kang Ji, Yeongjin Hong, Hisashi Ashida, Nobue Shishioh, Yoshiko Murakami, Yasu S. Morita, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 280　No. 10　p. 9489-9497　2005/03/11　Research paper (scientific journal)

GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol

Nobue Shishioh, Yeongjin Hong, Kazuhito Ohishi, Hisashi Ashida, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 280　No. 10　p. 9728-9734　2005/03/11　Research paper (scientific journal)

Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I

Hisashi Ashida, Yeongjin Hong, Yoshiko Murakami, Nobue Shishioh, Nakaba Sugimoto, Youn Uck Kim, Yusuke Maeda, Taroh Kinoshita

Molecular Biology of the Cell　Vol. 16　No. 3　p. 1439-1448　2005/03　Research paper (scientific journal)

Erythrocyte surface glycosylphosphatidyl inositol anchored receptor for the malaria parasite

Thanaporn Rungruang, Osamu Kaneko, Yoshiko Murakami, Takafumi Tsuboi, Hiroshi Hamamoto, Nobuyoshi Akimitsu, Kazuhisa Sekimizu, Taroh Kinoshita, Motomi Torii

Molecular and Biochemical Parasitology　Vol. 140　No. 1　p. 13-21　2005/03　Research paper (scientific journal)

Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization

Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi, Junji Takeda

Nature Medicine　Vol. 11　No. 2　p. 160-166　2005/02　Research paper (scientific journal)

Paroxysmal nocturnal hemoglobinuria

Mitsuhiro Omine, Taroh Kinoshita, Hideki Nakakuma, Jaroslaw P. Maciejewski, Charles J. Parker, Gérard Socié

International Journal of Hematology　Vol. 82　No. 5　p. 417-421　2005　Research paper (international conference proceedings)

Kola acuminata proanthocyanidins: A class of anti-trypanosomal compounds effective against Trypanosoma brucei

B. K. Kubata, Kisaburo Nagamune, Nobutoshi Murakami, Patrick Merkel, Zakayi Kabututu, Samuel K. Martin, Taba M. Kalulu, Haq Mustakuk, Mitsuru Yoshida, Mayumi Ohnishi-Kameyama, Taroh Kinoshita, Michael Duszenko, Yoshihiro Urade

International Journal for Parasitology　Vol. 35　No. 1　p. 91-103　2005/01　Research paper (scientific journal)

GPI-anchor deficiency in myeloid cells causes impaired FcγR effector functions

Wouter L.W. Hazenbos, Björn E. Clausen, Junji Takeda, Taroh Kinoshita

Blood　Vol. 104　No. 9　p. 2825-2831　2004/11/01　Research paper (scientific journal)

Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes

Wouter L.W. Hazenbos, Yoshiko Murakami, Jun Ichi Nishimura, Junji Takeda, Taroh Kinoshita

Journal of Immunology　Vol. 173　No. 6　p. 3810-3815　2004/09/15　Research paper (scientific journal)

Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene

Kosuke Yusa, Kyoji Horie, Gen Kondoh, Michiyoshi Kouno, Yusuke Maeda, Taroh Kinoshita, Junji Takeda

Nature　Vol. 429　No. 6994　p. 896-899　2004/06/24　Research paper (scientific journal)

Surface sialic acids taken from the host allow trypanosome survival in Tsetse fly vectors

Kisaburo Nagamune, Alvaro Acosta-Serrano, Haruki Uemura, Reto Brun, Christina Kunz-Renggli, Yusuke Maeda, Michael A.J. Ferguson, Taroh Kinoshita

Journal of Experimental Medicine　Vol. 199　No. 10　p. 1445-1450　2004/05/17　Research paper (scientific journal)

Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan

Jun Ichi Nishimura, Yuzuru Kanakura, Russell E. Ware, Tsutomu Shichishima, Hideki Nakakuma, Haruhiko Ninomiya, Carlos M. Decastro, Sharon Hall, Akihisa Kanamaru, Keith M. Sullivan, Hideaki Mizoguchi, Mitsuhiro Omine, Taroh Kinoshita, Wendell F. Rosse

Medicine　Vol. 83　No. 3　p. 193-207　2004/05　Research paper (scientific journal)

PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor

Yoshiko Murakami, Uamporn Siripanyapinyo, Yeongjin Hong, Ji Young Kang, Sonoko Ishihara, Hideki Nakakuma, Yusuke Maeda, Taroh Kinoshita

Molecular Biology of the Cell　Vol. 14　No. 10　p. 4285-4295　2003/10/01　Research paper (scientific journal)

GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits

Kisaburo Nagamune, Kazuhito Ohishi, Hisashi Ashida, Yeonchul Hong, Jun Hino, Kenji Kangawa, Norimitsu Inoue, Yusuke Maeda, Taroh Kinoshita

Proceedings of the National Academy of Sciences of the United States of America　Vol. 100　No. 19　p. 10682-10687　2003/09/16　Research paper (scientific journal)

Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins

Yeongjin Hong, Kazuhito Ohishi, Ji Young Kang, Satoshi Tanaka, Norimitsu Inoue, Jun Ichi Nishimura, Yusuke Maeda, Taroh Kinoshita

Molecular Biology of the Cell　Vol. 14　No. 5　p. 1780-1789　2003/05/01　Research paper (scientific journal)

Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge

Kazuhito Ohishi, Kisaburo Nagamune, Yusuke Maeda, Taroh Kinoshita

Journal of Biological Chemistry　Vol. 278　No. 16　p. 13959-13967　2003/04　Research paper (scientific journal)

Molecular genetics of paroxysmal nocturnal hemoglobinuria

Norimitsu Inoue, Yoshiko Murakami, Taroh Kinoshita

International Journal of Hematology　Vol. 77　No. 2　p. 107-112　2003/02　Research paper (scientific journal)

Two possible mechanisms for escape of GPI(-) cells from the immunological attack

Y Murakami, H Kosaka, J Takeda, T Kinoshita

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA AND RELATED DISORDERS　p. 225-227　2003　Research paper (international conference proceedings)

Inefficient response of t lymphocytes to glycosylphosphatidylinositol anchor-negative cells: Implications for paroxysmal nocturnal hemoglobinuria

Yoshiko Murakami, Hiroshi Kosaka, Yusuke Maeda, Jun Ichi Nishimura, Norimitsu Inoue, Kazuhito Ohishi, Masaru Okabe, Junji Takeda, Taroh Kinoshita

Blood　Vol. 100　No. 12　p. 4116-4122　2002/12/01　Research paper (scientific journal)

Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction

Chieko Yokoyama, Tomoko Yabuki, Manabu Shimonishi, Masayuki Wada, Toshihisa Hatae, Susumu Ohkawara, Junji Takeda, Taroh Kinoshita, Masaru Okabe, Tadashi Tanabe

Circulation　Vol. 106　No. 18　p. 2397-2403　2002/10/29　Research paper (scientific journal)

Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum α-toxin

Yeongjin Hong, Kazuhito Ohishi, Norimitsu Inoue, Ji Young Kang, Hiroaki Shime, Yasuhiko Horiguchi, F. Gisou Van der Goot, Nakaba Sugimoto, Taroh Kinoshita

EMBO Journal　Vol. 21　No. 19　p. 5047-5056　2002/10/01　Research paper (scientific journal)

Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex

Saulius Vainauskas, Yusuke Maeda, Henry Kurniawan, Taroh Kinoshita, Anant K. Menon

Journal of Biological Chemistry　Vol. 277　No. 34　p. 30535-30542　2002/08/23　Research paper (scientific journal)

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro

Shoichi Nagakura, Sonoko Ishihara, Daniel E. Dunn, Jun Ichi Nishimura, Tatsuya Kawaguchi, Kentaro Horikawa, Michihiro Hidaka, Tadashi Kagimoto, Nozomu Eto, Hiroaki Mitsuya, Taroh Kinoshita, Neal S. Young, Hideki Nakakuma

Blood　Vol. 100　No. 3　p. 1031-1037　2002/08/01　Research paper (scientific journal)

Long-term support of hematopoiesis by a single stem cell clone in patients with paroxysmal nocturnal hemoglobinuria

Jun Ichi Nishimura, Toshiyuki Hirota, Yuzuru Kanakura, Takashi Machii, Takashi Kageyama, Shoichi Doi, Hiroshi Wada, Toru Masaoka, Yoshio Kanayama, Hiroshi Fujii, Nobumasa Inoue, Maki Kuwayama, Norimitsu Inoue, Kazuhito Ohishi, Taroh Kinoshita

Blood　Vol. 99　No. 8　p. 2748-2751　2002/04　Research paper (scientific journal)

The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: The polypeptide moiety is required for the toxin-receptor interaction

Laurence Abrami, Marie Claire Velluz, Yeongjin Hong, Kazuhito Ohishi, Angela Mehlert, Michael Ferguson, Taroh Kinoshita, F. Gisou van der Goot

FEBS Letters　Vol. 512　No. 1-3　p. 249-254　2002/02/13　Research paper (scientific journal)

Relationship between aplastic anemia and paroxysmal nocturnal hemoglobinuria

Taroh Kinoshita, Norimitsu Inoue

International Journal of Hematology　Vol. 75　No. 2　p. 117-122　2002/02

The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant

Hosam Shams-Eldin, Nahid Azzouz, Mamdouh H. Kedees, Peter Orlean, Taroh Kinoshita, Ralph T. Schwarz

Molecular and Biochemical Parasitology　Vol. 120　No. 1　p. 73-81　2002　Research paper (scientific journal)

Transgenic pigs expressing human decay-accelerating factor regulated by porcine MCP gene promoter

Hiroshi Murakami, Hiroshi Nagashima, Yoichi Takahagi, Shuji Miyagawa, Tatsuya Fujimura, Koji Toyomura, Rie Nakai, Mako Yamada, Takashi Kurihara, Tamotsu Shigehisa, Masaru Okabe, Tsukasa Seya, Ryota Shirakura, Taroh Kinoshita

Molecular Reproduction and Development　Vol. 61　No. 3　p. 302-311　2002　Research paper (scientific journal)

Cross-talk between Caveolae and Glycosylphosphatidylinositol-rich Domains

Laurence Abrami, Marc Fivaz, Toshihide Kobayashi, Taroh Kinoshita, Robert G. Parton, F. Gisou Van der Goot

Journal of Biological Chemistry　Vol. 276　No. 33　p. 30729-30736　2001/08/17　Research paper (scientific journal)

PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

K. Ohishi, N. Inoue, T. Kinoshita

EMBO Journal　Vol. 20　No. 15　p. 4088-4098　2001/08/01　Research paper (scientific journal)

Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype

Jun Ichi Nishimura, Ken L. Phillips, Russell E. Ware, Sharon Hall, Lee Wilson, Tracy L. Gentry, Thad A. Howard, Yoshiko Murakami, Masaru Shibano, Takashi Machii, Eli Gilboa, Yuzuru Kanakura, Junji Takeda, Taroh Kinoshita, Wendell F. Rosse, Clay A. Smith

Blood　Vol. 97　No. 10　p. 3004-3010　2001/05/15　Research paper (scientific journal)

Its8, a Fission Yeast Homolog of Mcd4 and Pig-n, Is Involved in GPI Anchor Synthesis and Shares an Essential Function with Calcineurin in Cytokinesis

Tomoko Yada, Reiko Sugiura, Ayako Kita, Yuumi Itoh, Yabin Lu, Yeongjin Hong, Taroh Kinoshita, Hisato Shuntoh, Takayoshi Kuno

Journal of Biological Chemistry　Vol. 276　No. 17　p. 13579-13586　2001/04　Research paper (scientific journal)

PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER

Yusuke Maeda, Reika Watanabe, Claire L. Harris, Yeongjin Hong, Kazuhito Ohishi, Keiko Kinoshita, Taroh Kinoshita

EMBO Journal　Vol. 20　No. 1-2　p. 250-261　2001/01/15　Research paper (scientific journal)

Porcine MCP gene promoter directs high level expression of human DAF (CD55) in transgenic mice

Hiroshi Murakami, Yoichi Takahagi, Masao Yoshitatsu, Shuji Miyagawa, Tatsuya Fujimura, Koji Toyomura, Tamotsu Shigehisa, Ryota Shirakura, Taroh Kinoshita

Immunobiology　Vol. 201　No. 5　p. 583-597　2000/04　Research paper (scientific journal)

Altered T cell development in human thymorea is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-γ)

Y. Kadota, Meinoshin Okumura, S. Miyoshi, S. Kitagawa-Sakakida, M. Inoue, H. Shiono, Y. Maeda, T. Kinoshita, R. Shirakura, H. Matsuda

Clinical and Experimental Immunology　Vol. 121　No. 1　p. 59-68　2000　Research paper (scientific journal)

Molecular remodelling of human CD46 for xenotransplantation: Designing a potent complement regulator without measles virus receptor activity

N. A. Begum, Y. Murakami, S. Mikata, M. Matsumoto, M. Hatanaka, S. Nagasawa, T. Kinoshita, T. Seya

Immunology　Vol. 100　No. 1　p. 131-139　2000　Research paper (scientific journal)

Production of transgenic pigs expressing human DAF (CD55) regulated by the porcine MCP gene promoter

H. Murakami, H. Nagashima, Y. Takahagi, T. Fujimura, S. Miyagawa, M. Okabe, T. Seya, T. Shigehisa, N. Taniguchi, R. Shirakura, T. Kinoshita

Transplantation Proceedings　Vol. 32　No. 7　p. 2505-2506　2000　Research paper (scientific journal)

Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis

Taroh Kinoshita, Norimitsu Inoue

Current Opinion in Chemical Biology　Vol. 4　No. 6　p. 632-638　2000

A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: A possible role for regulation of neutrophil adherence and migration

Kichiya Suzuki, Tadashi Watanabe, Shin Ichi Sakurai, Kazuhisa Ohtake, Taroh Kinoshita, Akemi Araki, Teizo Fujita, Hiroshi Takei, Yuji Takeda, Yukiko Sato, Takao Yamashita, Yoshihiko Araki, Fujiro Sendo

Journal of Immunology　Vol. 162　No. 7　p. 4277-4284　1999/04　Research paper (scientific journal)

CD59-deficient blood cells and PIG-A gene abnormalities in Japanese patients with aplastic anaemia

Yasuhiko Azenishi, Etsuko Ueda, Takashi Machii, Jun Ichi Nishimura, Toshiyuki Hirota, Masaru Shibano, Shinji Nakao, Taroh Kinoshita, Hideaki Mizoguchi, Teruo Kitani

British Journal of Haematology　Vol. 104　No. 3　p. 523-529　1999　Research paper (scientific journal)

Genotypic, immunophenotypic and clinical features of Thai patients with paroxysmal nocturnal haemoglobinuria

Patcharin Pramoonjago, Kriangsakdi Pakdeesuwan, Uamporn Siripanyaphinyo, Sriprapa Chinprasertsuk, Taroh Kinoshita, Wanchai Wanachiwanawin

British Journal of Haematology　Vol. 105　No. 2　p. 497-504　1999　Research paper (scientific journal)

Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: Genomic structures, chromosome loci and the presence of a minor class intron

N. Inoue, K. Ohishi, Y. Endo, T. Fujita, J. Takeda, Taroh Kinoshita

Cytogenetics and Cell Genetics　Vol. 84　No. 3-4　p. 199-205　1999　Research paper (scientific journal)

Antibody binding to individual short consensus repeats of decay- accelerating factor enhances enterovirus cell attachment and infectivity

Darren R. Shafren, Douglas J. Dorahy, Rick F. Thorne, Taroh Kinoshita, Richard D. Barry, Gordon F. Burns

Journal of Immunology　Vol. 160　No. 5　p. 2318-2323　1998/03/01　Research paper (scientific journal)

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

Masato Matsuki, Fumiyoshi Yamashita, Akemi Ishida-Yamamoto, Keiko Yamada, Chikako Kinoshita, Shinji Fushiki, Eiichiro Ueda, Yohichi Morishima, Kohichi Tabata, Hirokazu Yasuno, Mitsuru Hashida, Hajime Iizuka, Masahito Ikawa, Masaru Okabe, Gen Kondoh, Taroh Kinoshita, Junji Takeda, Kiyofumi Yamanishi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 95　No. 3　p. 1044-1049　1998/02/03　Research paper (scientific journal)

Differentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3',5' cyclic adenosine monophosphate

I. K. Zarkadis, A. Omigbodun, A. Forson, P. Ziolkiewicz, T. Kinoshita, J. D. Lambris, C. Coutifaris

Journal of the Society for Gynecologic Investigation　Vol. 4　No. 1　p. 47-53　1997/01　Research paper (scientific journal)

Expression cloning of pig-l, a gene involved in deacetylation of n-acetylglucosaminyl phosphatidylinositol, a gpi intermediate

N. Nakamura, N. Lnoue, R. Watanabe, M. Larahashl, J. Lakeda, V. L. Stevens, T. Kinoshita

FASEB Journal　Vol. 11　No. 9　1997　Research paper (scientific journal)

GPI-N-acetylglucosaminyl transferase for the first step of glycosylphosphatidylinositol biosynthesis is mediated by protein complex composed of PIG-A, PIG-H, PIG-C and HGPI 1

R. Watanabe, N. Inoue, B. Westfall, C. H. Taron, P. Orlean, J. Takeda, T. Kinoshita

FASEB Journal　Vol. 11　No. 9　1997　Research paper (scientific journal)

Mouse GAA1 homologue is involved in transfeit of the GPI anchor to proteins

K. Ohishi, N. Inoue, J. Takeda, M. E. Medof, D. Hamburger, H. Riezman, T. Kinoshita

FASEB Journal　Vol. 11　No. 9　1997　Research paper (scientific journal)

A new rat gene involved in biosynthesis of dolichol-phosphate-mannose

Y. Maeda, S. Tomita, J. Takeda, T. Kinoshita

FASEB Journal　Vol. 11　No. 9　1997　Research paper (scientific journal)

Biological consequences of defects in gpi-anchor processing

T. Kinoshita, J. Takeda

FASEB Journal　Vol. 11　No. 9　1997　Research paper (scientific journal)

Genotypic and phenotypic implications in paroxysmal nocturnal hemoglobinuria (PNH): A preliminary investigation

Kriangsak Pakdeesuwan, Uamporn Siripanyaphinyo, Patcharin Pramoonjago, Kovit Pattanapanyasat, Prapon Wilairat, Taroh Kinoshita, Wanchai Wanachiwanawin

Southeast Asian Journal of Tropical Medicine and Public Health　Vol. 28　p. 58-63　1997　Research paper (scientific journal)

Exposure of astrocytes to hypoxia/reoxygenation enhances expression of glucose-regulated protein 78 facilitating astrocyte release of the neuroprotective cytokine interleukin 6

Osamu Hori, Masayasu Matsumoto, Keisuke Kuwabara, Yusuke Maeda, Hirokazu Ueda, Toshiho Ohtsuki, Taroh Kinoshita, Satoshi Ogawa, David M. Stern, Takenobu Kamada

Journal of Neurochemistry　Vol. 66　No. 3　p. 973-979　1996/03　Research paper (scientific journal)

Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain

Keisuke Kuwabara, Masayasu Matsumoto, Jun Ikeda, Osamu Hori, Satoshi Ogawa, Yusuke Maeda, Kazuo Kitagawa, Naohiko Imuta, Taroh Kinoshita, David M. Stern, Hideki Yanagi, Takenobu Kamada

Journal of Biological Chemistry　Vol. 271　No. 9　p. 5025-5032　1996/03/01　Research paper (scientific journal)

Protection of host from its own complement by membrane-bound complement inhibitors: C3 convertase inhibitors vs membrane attack complex inhibitors

T. Kinoshita

Research in Immunology　Vol. 147　No. 2　p. 100-103　1996　Research paper (scientific journal)

Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3: An initial model of ligand interaction with two linked short consensus repeat modules

H. Molina, S. J. Perkins, J. Guthridge, J. Gorka, T. Kinoshita, V. M. Holers

Journal of Immunology　Vol. 154　No. 10　p. 5426-5435　1995　Research paper (scientific journal)

PIG-A gene abnormalities in Thai patients with paroxysmal nocturnal hemoglobinuria.

P. Pramoonjago, W. Wanachiwanawin, S. Chinprasertsuk, K. Pattanapanyasat, J. Takeda, T. Kinoshita

The Southeast Asian journal of tropical medicine and public health　Vol. 26 Suppl 1　p. 322-324　1995　Research paper (scientific journal)

Antibodies to murine complement receptor 1 and 2 can inhibit the antibody response in vivo without inhibiting T helper cell induction

S. Gustavsson, T. Kinoshita, B. Heyman

Journal of Immunology　Vol. 154　No. 12　p. 6524-6528　1995　Research paper (scientific journal)

Mouse complement regulatory protein crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein

Youn Uck Kim, Taroh Kinoshita, Hector Molina, Dennis Hourcade, Tsukasa Seya, Lynne M. Wagner, V. Michael Holers

Journal of Experimental Medicine　Vol. 181　No. 1　p. 151-159　1995/01/01　Research paper (scientific journal)

Expression Cloning Strategies for Glycosylphosphatidylinositol-Anchor Biosynthesis Enzymes and Regulators

Taroh Kinoshita, Toshio Miyata, Norimitsu Inoue, Junji Takeda

Methods in Enzymology　Vol. 250　No. C　p. 547-560　1995　Research paper (scientific journal)

Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: A paracrine mechanism potentially enhancing neuron survival

Yusuke Maeda, Masayasu Matsumoto, Osamu Hori, Keisuke Kuwabara, Satoshi Ogawa, Shi Du Yan, Toshiho Ohtsuki, Taroh Kinoshita, Takenobu Kamada

Journal of Experimental Medicine　Vol. 180　No. 6　p. 2297-2308　1994/12/01　Research paper (scientific journal)

Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2

Hector Molina, Taroh Kinoshita, Carol Brenner Webster, V. Michael Holers

Journal of Immunology　Vol. 153　No. 2　p. 789-795　1994/07/15　Research paper (scientific journal)

Metabolic and Biosynthetic Alterations in Cultured Astrocytes Exposed to Hypoxia/Reoxygenation

Osamu Hori, Masayasu Matsumoto, Yusuke Maeda, Hirokazu Ueda, Toshiho Ohtsuki, David M. Stern, Taroh Kinoshita, Satoshi Ogawa, Takenobu Kamada

Journal of Neurochemistry　Vol. 62　No. 4　p. 1489-1495　1994/04　Research paper (scientific journal)

Expression cloning of genes for GPI-anchor biosynthesis.

T. Kinoshita, M. Takahashi, N. Inoue, T. Miyata, J. Takeda

Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]　Vol. 27　No. 2　p. 127-132　1994/02　Research paper (scientific journal)

A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin

Tatsuyoshi Nakagami, Koji Toyomura, Taroh Kinoshita, Seiji Morisawa

BBA - General Subjects　Vol. 1158　No. 2　p. 189-193　1993/10/03　Research paper (scientific journal)

β<inf>2</inf>-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis

Toshio Miyata, Osamu Oda, Reiko Inagi, Yoshiyasu Iida, Norie Araki, Norio Yamada, Seikoh Horiuchi, Naoyuki Taniguchi, Kenji Maeda, Taroh Kinoshita

Journal of Clinical Investigation　Vol. 92　No. 3　p. 1243-1252　1993/09　Research paper (scientific journal)

A monoclonal antibody against human decay-accelerating factor (DAF, CD55), D17, which lacks reactivity with semen-DAF

Tomoko Hara, Misako Matsumoto, Yasuo Fukumori, Shuji Miyagawa, Michiyo Hatanaka, Taroh Kinoshita, Tsukasa Seya, Hitoshi Akedo

Immunology Letters　Vol. 37　No. 2-3　p. 145-152　1993/08　Research paper (scientific journal)

Antibody Feedback Regulation in MRL/lpr Mice

Birgitta Heyman, Susanne Gustavsson, Chikashi Kusakari, Masato Nose, Taroh Kinoshita, Lars Klareskog, Andrej Tarkowski

Journal of Autoimmunity　Vol. 6　No. 4　p. 437-448　1993/08　Research paper (scientific journal)

The biological roles of the third component of complement in osteoclast formation

Toshiyuki Sato, Etsuko Abe, Cheng He Jin, Mei Hua Hong, Takenobu Katagiri, Taroh Kinoshita, Norio Amizuka, Hidehiro Ozawa, Tatsuo Suda

Endocrinology　Vol. 133　No. 1　p. 397-404　1993/07　Research paper (scientific journal)

Functional properties of the allotypes of mouse complement regulatory protein, factor H: Difference of compatibility of each allotype with human factor I

Okada Michiyo, Kojima Ayako, Takano Hiromi, Harada Yoshinobu, Nonaka Mayumi, Nonaka Masaru, Kinoshita Taroh, Seya Tsukasa, Natsuume Sakai Shunnosuke

Molecular Immunology　Vol. 30　No. 9　p. 841-848　1993/06　Research paper (scientific journal)

Characteristics of the epitope of protein-reactive anti-peptide antibodies

Akemi Ota, Jiro Seki, Xiao Liang Lin, Yu Zhao, Xiaohui Wang, Kiyoshi Kondo, Nobuo Sakato, Taroh Kinoshita, Hajime Fujio

Journal of Biochemistry　Vol. 113　No. 3　p. 314-320　1993/03　Research paper (scientific journal)

The immunosuppressive action of anti-CD18 monoclonal antibody in rat heterotopic heart allotransplantation

Hiroshi Kameoka, Michio Ishibashi, Takuya Tamatani, Yuji Takano, Abdelhakim Moutabarrik, Hongsi Jiang, Yukito Kokado, Shiro Takahara, Akihiko Okuyama, Taroh Kinoshita, Masayuki Miyasaka

Transplantation　Vol. 55　No. 3　p. 665-667　1993/03　Research paper (scientific journal)

Comparative immunosuppressive effect of anti-CD18 and anti-CD11a monoclonal antibodies on rat heart allotransplantation

H. Kameoka, M. Ishibashi, T. Tamatani, Y. Takano, A. Moutabarrik, H. Jiang, Y. Kokado, S. Takahara, M. Miyasaka, A. Okuyama, T. Kinoshita, T. Sonoda

Transplantation Proceedings　Vol. 25　No. 1　p. 833-836　1993　Research paper (international conference proceedings)

Inhibitory effect of the complement receptor-specific monoclonal antibody on the induced antibody response and the role of CD4⁺ and CD8⁺ T-cells in the rat to mouse xenotransplantation

G. Matsumiya, R. Shirakura, S. Miyagawa, S. Nakata, S. Nakano, T. Kinoshita, H. Matsuda

Transplantation Proceedings　Vol. 25　No. 1　p. 402-404　1993　Research paper (international conference proceedings)

Ligand specificities of mouse complement receptor types 1 (CR1) and 2 (CR2) purified from spleen cells

Patcharin Pramoonjago, Junjl Takeda, Youn Uck Kim, Kozo Inoue, Taroh Kinoshita

International Immunology　Vol. 5　No. 4　p. 337-343　1993　Research paper (scientific journal)

Cloning of a human gene, PIG-F, a component of glycosyl- phosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy

N. Inoue, T. Kinoshita, T. Orii, J. Takeda

Journal of Biological Chemistry　Vol. 268　No. 10　p. 6882-6885　1993　Research paper (scientific journal)

Deficient surface expression of glycosylphosphatidylinositol-anchored proteins in B cell lines established from patients with paroxysmal nocturnal hemoglobinuria

Etsuko Ueda, Jun ichl Nishimura, Teruo Kitani, Kaori Nasu, Takashi Kageyama, Youn Uck Kim, Junjl Takeda, Taroh Kinoshita

International Immunology　Vol. 4　No. 11　p. 1263-1271　1992/11　Research paper (scientific journal)

Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor

K. E. Coyne, S. E. Hall, E. S. Thompson, M. A. Arce, T. Kinoshita, T. Fujita, D. J. Anstee, W. Rosse, D. M. Lublin

Journal of Immunology　Vol. 149　No. 9　p. 2906-2913　1992　Research paper (scientific journal)

Bactericidal activity of C9-deficient human serum

P. Pramoonjago, T. Kinoshita, K. Hong, Y. Takata-Kozono, H. Kozono, R. Inagi, K. Inoue

Journal of Immunology　Vol. 148　No. 3　p. 837-843　1992　Research paper (scientific journal)

Phylogeny of the third component of complement, C3: Analysis of the conservation of human CR1, CR2, H, and B binding sites, concanavalin A binding sites, and thiolester bond in the C3 from different species

Jochem Alsenz, David Avila, Hartwig P. Huemer, Inmaculada Esparza, J. David Becherer, Taroh Kinoshita, Yang Wang, Sabine Oppermann, John D. Lambris

Developmental and Comparative Immunology　Vol. 16　No. 1　p. 63-76　1992　Research paper (scientific journal)

Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and crry, the two genetic homologues of human CR1

Hector Molina, Winnie Wong, Taroh Kinoshita, Carol Brenner, Sharon Foley, V. Michael Holers

Journal of Experimental Medicine　Vol. 175　No. 1　p. 121-123　1992/01/01　Research paper (scientific journal)

Fluid-phase activation of the alternative pathway of complement by excess factor D in regularly dialyzed patients

T. Miyata, R. Inagi, K. Hong, Y. Iida, O. Oda, T. Kinoshita, K. Inoue, A. Miyama, K. Maeda

Nephron　Vol. 60　No. 2　p. 144-149　1992　Research paper (scientific journal)

Role of TraT protein, an anticomplementary protein produced in Escherichia coli by R100 factor, in serum resistance

P. Pramoonjago, M. Kaneko, T. Kinoshita, E. Ohtsubo, J. Takeda, K. Hong, R. Inagi, K. Inoue

Journal of Immunology　Vol. 148　No. 3　p. 827-836　1992　Research paper (scientific journal)

Inhibition of immunological memory and T‐independent humoral responses by monoclonal antibodies specific for murine complement receptors

Erik J. Wiersma, Taroh Kinoshita, Birgitta Heyman

European Journal of Immunology　Vol. 21　No. 10　p. 2501-2506　1991/10　Research paper (scientific journal)

Preferential inactivation of the C5 convertase of the alternative complement pathway by factor I and membrane cofactor protein (MCP)

Seya Tsukasa, Okada Michiyo, Matsumoto Misako, Hong Kyongsu, Kinoshita Taroh, John P. Atkinson

Molecular Immunology　Vol. 28　No. 10　p. 1137-1147　1991/10　Research paper (scientific journal)

Paroxysmal nocturnal hemoglobinuria and GPI-anchored membrane proteins

T. Kinoshita

Rinsho byori. The Japanese journal of clinical pathology　Vol. Suppl 91　p. 74-81　1991/09　Research paper (scientific journal)

Deficiency of complement decay-accelerating factor (DAF, CD55) in non-Hodgkin's lymphoma

Hiroko Fukuda, Tsukasa Seya, Tomoko Hara, Misako Matsumoto, Taroh Kinoshita, Toru Masaoka

Immunology Letters　Vol. 29　No. 3　p. 205-209　1991/08　Research paper (scientific journal)

Modulation of mouse complement receptors 1 and 2 suppresses antibody responses in vivo

G. Thyphronitis, T. Kinoshita, K. Inoue, J. E. Schweinle, G. C. Tsokos, E. S. Metcalf, F. D. Finkelman, J. E. Balow

Journal of Immunology　Vol. 147　No. 1　p. 224-230　1991　Research paper (scientific journal)

Analysis of Epstein-Barr virus-binding sites on complement receptor 2 (CR2/CD21) using human-mouse chimeras and peptides: At least two distinct sites are necessary for ligand-receptor interaction

H. Molina, C. Brenner, S. Jacobi, J. Gorka, J. C. Carel, T. Kinoshita, V. M. Holers

Journal of Biological Chemistry　Vol. 266　No. 19　p. 12173-12179　1991　Research paper (scientific journal)

Reconstitution of C5 convertase of the alternative complement pathway with isolated C3b dimer and factors B and D

K. Hong, T. Kinoshita, P. Pramoonjago, Youn Uck Kim, T. Seya, K. Inoue

Journal of Immunology　Vol. 146　No. 6　p. 1868-1873　1991　Research paper (scientific journal)

Murine monoclonal anti-Ba antibody that enhances haemolytic activity of factor B

E. Tanaka, K. Hong, T. Kinoshita, Y. Takata, H. Kozono, J. Takeda, A. Yoden, K. Inoue

Immunology　Vol. 73　No. 4　p. 383-387　1991　Research paper (scientific journal)

Inherited complete deficiency of 20-kilodalton homologous restriction factor (cd59) as a cause of paroxysmal nocturnal hemoglobinuria

Manabu Yamashina, Etsuko Ueda, Taroh Kinoshita, Tsuyoshi Takami, Akitsugu Ojima, Hiromasa Ono, Hiroshi Tanaka, Naomi Kondo, Tadao Orii, Noriko Okada, Hidechika Okada, Kozo Inoue, Teruo Kitani

New England Journal of Medicine　Vol. 323　No. 17　p. 1184-1189　1990/10/25　Research paper (scientific journal)

Inhibition of the alternative C3 convertase and classical C5 convertase of complement by group A streptococcal M protein

K. Hong, T. Kinoshita, J. Takeda, H. Kozono, P. Pramoonjago, Y. U. Kim, K. Inoue

Infection and Immunity　Vol. 58　No. 8　p. 2535-2541　1990　Research paper (scientific journal)

Proteolytic elimination of decay-accelerating factor (DAF): Lytic abnormality coincides with removal of DAF in papain-treated human erythrocytes

Seya Tsukasa, Inoue Hiroaki, Okada Michiyo, Matsumoto Misako, Kitamura Hajime, Kinoshita Taroh, Akedo Hitoshi

Molecular Immunology　Vol. 27　No. 1　p. 69-78　1990/01　Research paper (scientific journal)

Interactions between murine B lymphocyte surface membrane molecules. Loaded but not free receptors for complement and the Fc portion of IgG Co-Cap independently with cross-linked surface Ig

G. C. Tsokos, T. Kinoshita, G. Thyphronitis, A. D. Patel, H. B. Dickler, F. D. Finkelman

Journal of Immunology　Vol. 144　No. 1　p. 239-243　1990　Research paper (scientific journal)

Acetylcholinesterase and lymphocyte function-associated antigen 3 found on decay-accelerating factor-negative erythrocytes from some patients with paroxysmal nocturnal hemoglobinuria are lost during erythrocyte aging

E. Ueda, T. Kinoshita, T. Terasawa, T. Shichishima, Y. Yawata, K. Inoue, T. Kitani

Blood　Vol. 75　No. 3　p. 762-769　1990　Research paper (scientific journal)

A molecular and immunochemical characterization of mouse CR2: Evidence for a single gene model of mouse complement receptors 1 and 2

H. Molina, T. Kinoshita, K. Inoue, J. C. Carel, V. M. Holers

Journal of Immunology　Vol. 145　No. 9　p. 2974-2983　1990　Research paper (scientific journal)

Complement receptors

T. Kinoshita

Seikagaku. The Journal of Japanese Biochemical Society　Vol. 61　No. 8　p. 704-709　1989/08　Research paper (scientific journal)

Different membrane anchors of FCγRIII (CD16) on K/NK-lymphocytes and neutrophils. Protein- vs lipid-anchor

E. Ueda, T. Kinoshita, J. Nojima, K. Inoue, T. Kitani

Journal of Immunology　Vol. 143　No. 4　p. 1274-1277　1989　Research paper (scientific journal)

The low C5 convertase activity of the C4A6 allotype of human complement component C4

T. Kinoshita, A. W. Dodds, S. K.A. Law, K. Inoue

Biochemical Journal　Vol. 261　No. 3　p. 743-748　1989　Research paper (scientific journal)

Different distribution of decay-accelerating factor on hematopoietic progenitors from normal individuals and patients with paroxysmal nocturnal hemoglobinuria

A. Kanamaru, K. Okuda, E. Ueda, T. Kitani, T. Kinoshita, K. Nagai

Blood　Vol. 72　No. 2　p. 507-511　1988　Research paper (scientific journal)

Rapid and simple measurement of human C5a-des-Arg level in plasma or serum using monoclonal antibodies

Junji Takeda, Taroh Kinoshita, Yuko Takata, Haruo Kozono, Etsuko Tanaka, Kyongsu Hong, Kozo Inoue

Journal of Immunological Methods　Vol. 101　No. 2　p. 265-270　1987/08/03　Research paper (scientific journal)

Relationship between decay accelerating factor deficiency, diminished acetylcholinesterase activity, and defective terminal complement pathway restriction in paroxymal nocturnal hemoglobinuria erythrocytes

M. E. Medof, A. Gottlieb, T. Kinoshita, S. Hall, R. Silber, V. Nussenzweig, W. F. Rosse

Journal of Clinical Investigation　Vol. 80　No. 1　p. 165-174　1987　Research paper (scientific journal)

A high m.w. form of decay-accelerating factor (DAF-2) exhibits size abnormalities in paroxysmal nocturnal hemoglobinuria erythrocytes

T. Kinoshita, S. I. Rosenfeld, V. Nussenzweig

Journal of Immunology　Vol. 138　No. 9　p. 2994-2998　1987　Research paper (scientific journal)

Membrane-bound C4b interacts endogenously with complement receptor CRI of human red cells

Taroh Kinoshita, M. Edward Medof, Kyongsu Hong, Victor Nussenzweig

Journal of Experimental Medicine　Vol. 164　No. 5　p. 1377-1388　1986/11/01　Research paper (scientific journal)

Decay-accelerating factor is present on cultured human umbilical vein endothelial cells

Adam S. Asch, Taroh Kinoshita, Eric A. Jaffe, Victor Nussenzweig

Journal of Experimental Medicine　Vol. 163　No. 1　p. 221-226　1986/01/01　Research paper (scientific journal)

Endogenous association of decay-accelerating factor (DAF) with C4b and C3b on cell membranes

T. Kinoshita, M. E. Medof, V. Nussenzweig

Journal of Immunology　Vol. 136　No. 9　p. 3390-3395　1986　Research paper (scientific journal)

Number of Hits Necessary for Complement-Mediated Hemolysis

Junji Takeda, Haruo Kozono, Yuko Takata, Taroh Kinoshita, Etsuko Tanaka, Kozo Inoue

MICROBIOLOGY and IMMUNOLOGY　Vol. 30　No. 5　p. 461-468　1986　Research paper (scientific journal)

Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor

M. E. Medof, T. Kinoshita, R. Silber, V. Nussenzweig

Proceedings of the National Academy of Sciences of the United States of America　Vol. 82　No. 9　p. 2980-2984　1985　Research paper (scientific journal)

Partial correction of the lytic abnormalities of paroxysmal nocturnal hemoglobinuria cells with decay accelerating factor

M. E. Medof, T. Kinoshita, R. Silber, V. Nussenzweig

Federation Proceedings　Vol. 44　No. 3　1985　Research paper (scientific journal)

Regulatory proteins for the activated third and fourth components of complement (C3b and C4b) in mice. II. Identification and properties of complement receptor type 1(CR1)

T. Kinoshita, S. Lavoie, V. Nussenzweig

Journal of Immunology　Vol. 134　No. 4　p. 2564-2570　1985　Research paper (scientific journal)

Regulatory proteins for the activated third and fourth components of complement (C3b and C4b) in mice. I. Isolation and characterization of factor H: the serum cofactor for the C3b/C4b inactivator (Factor I)

Taroh Kinoshita, Victor Nussenzweig

Journal of Immunological Methods　Vol. 71　No. 2　p. 247-257　1984/07/06　Research paper (scientific journal)

Functional properties of factor H and the membrane complement receptor for C3b, C4b (CR1) in mice

T. Kinoshita, V. Nussenzweig

Federation Proceedings　Vol. 43　No. 6　1984　Research paper (scientific journal)

Effects of K-76 monocarboxylic acid, an anticomplementary agent, on various in vivo immunological reactions and on experimental glomerulonephritis

W. Miyazaki, T. Izawa, Y. Nakano, M. Shinohara, K. Hing, T. Kinoshita, K. Inoue

Complement　Vol. 1　No. 3　p. 134-146　1984　Research paper (scientific journal)

Inhibition of immune precipitation by complement

K. Hong, Y. Takata, K. Sayama, H. Kozono, J. Takeda, Y. Nakano, T. Kinoshita, K. Inoue

Journal of Immunology　Vol. 133　No. 3　p. 1464-1470　1984　Research paper (scientific journal)

Interaction of the Eighth Component of Guinea Pig Complement (C8) with the Membrane‐Bound C5b‐7 Complex: The Binding Site of C8 to C5b‐7 Is Formed on Association of the α‐γ Subunit with the β‐Chain

Taroh Kinoshita, Kyongsu Hong, Kozo Inoue

Microbiology and Immunology　Vol. 27　No. 4　p. 369-375　1983/04　Research paper (scientific journal)

Eighth component of guinea pig complement: Purification and characterization

Kinoshita Taroh, Hong Kyongsu, Kondo Kiyoshi, Inoue Kozo

Molecular Immunology　Vol. 19　No. 4　p. 589-597　1982/04　Research paper (scientific journal)

Effect of trysinization on the activity of human factor H

K. Hong, T. Kinoshita, Y. Dohi, K. Inoue

Journal of Immunology　Vol. 129　No. 2　p. 647-652　1982　Research paper (scientific journal)

Soluble C5b-9 complex of guinea pig complement: Demonstration of its heterogeneity and the mechanism of its C9 hemolytic activity as transfer of reversibly bound C9 molecules from the complex

Kinoshita Taroh, Hong Kyongsu, Inoue Kozo

Molecular Immunology　Vol. 18　No. 5　p. 423-431　1981/05　Research paper (scientific journal)

Inhibitory effect of K-76 monocarboxylic acid, an anticomplementary agent, on the C3b inactivator system

K. Hong, T. Kinoshita, H. Kitajima, K. Inoue

Journal of Immunology　Vol. 127　No. 1　p. 104-108　1981　Research paper (scientific journal)

Simple methods for preparing EAC1,4b,2a,3b and EAC4b,3b with human or guinea pig complement components using an anticomplementary agent, K-76 monocarboxylic acid

K. Hong, T. Kinoshita, K. Inoue

Journal of Immunology　Vol. 127　No. 1　p. 109-114　1981　Research paper (scientific journal)

Fifth component of guinea pig complement: Purification and characterization

T. Kinoshita, K. Hong, K. Kondo, K. Inoue

Journal of Immunology　Vol. 126　No. 6　p. 2414-2418　1981　Research paper (scientific journal)

A Complement Inhibitor Produced by Stachybotrys complementi, nov. sp. K-76, a New Species of Fungi Imperfecti

Wasei Miyazaki, Hisashi Tamaoka, Masanao Shinohara, Hirotsugu Kaise, Taketoshi Izawa, Yoshimasa Nakano, Taroh Kinoshita, Kyongsu Hong, Kozo Inoue

MICROBIOLOGY and IMMUNOLOGY　Vol. 24　No. 11　p. 1091-1108　1980　Research paper (scientific journal)

C9 hemolytic activity of the soluble C5b-9 complex of guinea pig complement, analogous to human SC5b-9

T. Kinoshita, K. Hong, K. Inoue

Journal of Immunology　Vol. 123　No. 5　p. 1989-1995　1979　Research paper (scientific journal)

An anticomplementary agent, K-76 monocarboxylic acid: Its site and mechanism of inhibition of the complement activation cascade

K. Hong, T. Kinoshita, W. Miyazaki, T. Izawa, K. Inoue

Journal of Immunology　Vol. 122　No. 6　p. 2418-2423　1979　Research paper (scientific journal)

Bactericidal activity of the normal, cell free hemolymph of silkworms (Bombyx mori)

T. Kinoshita, K. Inoue

Infection and Immunity　Vol. 16　No. 1　p. 32-36　1977　Research paper (scientific journal)

Release of phospholipids from complement mediated lesions on the surface structure of Escherichia coli

K. Inoue, T. Kinoshita, M. Okada, Y. Akiyama

Journal of Immunology　Vol. 119　No. 1　p. 65-72　1977　Research paper (scientific journal)

Release of phospholipids from liposomal model membrane damaged by antibody and complement

T. Kinoshita, K. Inoue, M. Okada, Y. Akiyama

Journal of Immunology　Vol. 119　No. 1　p. 73-78　1977　Research paper (scientific journal)

Evidence for a one hit theory in the immune bactericidal reaction and demonstration of a multi hit response for hemolysis by streptolysin O and Clostridium perfringens theta toxin

Kozo Inoue, Yoko Akiyama, Taroh Kinoshita, Yasushi Higashi, Tsunehisa Amano

Infection and Immunity　Vol. 13　No. 2　p. 337-344　1976　Research paper (scientific journal)