Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.

Kaoru Seiriki, Atsushi Kasai, Takanobu Nakazawa, Misaki Niu, Yuichiro Naka, Masato Tanuma, Hisato Igarashi, Kosei Yamaura, Atsuko Hayata-Takano, Yukio Ago, Hitoshi Hashimoto

Nature protocols　Vol. 14　No. 5　p. 1509-1529　2019/05　Research paper (scientific journal)

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

Kaoru Seiriki, Atsushi Kasai, Takeshi Hashimoto, Wiebke Schulze, Misaki Niu, Shun Yamaguchi, Takanobu Nakazawa, Ken-ichi Inoue, Shiori Uezono, Masahiko Takada, Yuichiro Naka, Hisato Igarashi, Masato Tanuma, James A. Waschek, Yukio Ago, Kenji F. Tanaka, Atsuko Hayata-Takano, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Hirooki Yabe, Takeharu Nagai, Katsumasa Fujita, Toshio Matsuda, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto

Neuron　Vol. 94　No. 6　p. 1085-+　2017/06　Research paper (scientific journal)

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice

Kaoru Seiriki, Atsushi Kasai, Takahiro Kuwaki, Takanobu Nakazawa, Shun Yamaguchi, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 480　No. 4　p. 558-563　2016/11　Research paper (scientific journal)

Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo.

Taro Ichimura, Taishi Kakizuka, Yoshitsugu Taniguchi, Satoshi Ejima, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Ko Sugawara, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

eLife　Vol. 13　2025/02/03　Research paper (scientific journal)

Socially activated neurons in the anterior cingulate cortex are essential for social behavior in mice

Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto, Takanobu Nakazawa

Biochemical and Biophysical Research Communications　p. 150251-150251　2024/06　Research paper (scientific journal)

(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.

Rei Yokoyama, Yukio Ago, Hisato Igarashi, Momoko Higuchi, Masato Tanuma, Yuto Shimazaki, Takafumi Kawai, Kaoru Seiriki, Misuzu Hayashida, Shun Yamaguchi, Hirokazu Tanaka, Takanobu Nakazawa, Yasushi Okamura, Kenji Hashimoto, Atsushi Kasai, Hitoshi Hashimoto

Molecular psychiatry　2024/02/23　Research paper (scientific journal)

Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice.

Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Hisato Igarashi, Kaoru Seiriki, Takanobu Nakazawa, Atsushi Kasai, Yukio Ago, Hitoshi Hashimoto

Journal of pharmacological sciences　Vol. 154　No. 2　p. 72-76　2024/02　Research paper (scientific journal)

Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience

Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko

Cell Reports　Vol. 42　No. 3　p. 112149-112149　2023/03　Research paper (scientific journal)

Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala

Masato Tanuma, Misaki Niu, Jin Ohkubo, Hiroki Ueno, Yuka Nakai, Yoshihisa Yokoyama, Kaoru Seiriki, Hitoshi Hashimoto, Atsushi Kasai

Molecular Brain　Vol. 15　No. 1　2022/12/20　Research paper (scientific journal)

Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 15　No. 1　p. 34-34　2022/04/11　Research paper (scientific journal)

Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 15　No. 1　p. 26-26　2022/03/28　Research paper (scientific journal)

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.

Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto

Science advances　Vol. 8　No. 11　2022/03/18　Research paper (scientific journal)

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.

Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura, Kazuki Nagayasu, Yoshinori Tsurusaki, Noriko Miyake, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Mikiya Fujiwara, Masayuki Baba, Kohei Kitagawa, Tomoya Takemoto, Nanaka Gotoda-Nishimura, Tomohiro Takada, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Satoshi Kida, Kazuhiro Takuma, Fumihito Ono, Naomichi Matsumoto, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Translational psychiatry　Vol. 11　No. 1　p. 548-548　2021/10/25　Research paper (scientific journal)

Exploring rare cellular activity in more than one million cells by a transscale scope

T. Ichimura, T. Kakizuka, K. Horikawa, K. Seiriki, A. Kasai, H. Hashimoto, K. Fujita, T. M. Watanabe, T. Nagai

Scientific Reports　Vol. 11　No. 1　2021/08　Research paper (scientific journal)

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder.

Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 14　No. 1　p. 56-56　2021/03/16　Research paper (scientific journal)

Altered Functional Connectivity of the Orbital Cortex and Striatum Associated with Catalepsy Induced by Dopamine D1 and D2 Antagonists.

Misaki Niu, Atsushi Kasai, Kaoru Seiriki, Misuzu Hayashida, Masato Tanuma, Rei Yokoyama, Yumi Hirato, Hitoshi Hashimoto

Biological & pharmaceutical bulletin　Vol. 44　No. 3　p. 442-447　2021　Research paper (scientific journal)

Trans-scale-scope to find rare cellular activity in sub-million cells

Taro Ichimura, Taishi Kakizuka, Kazuki Horikawa, Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto, Katsumasa Fujita, Tomonobu M. Watanabe, Takeharu Nagai

2020/06/30

Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain

Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto

JCI Insight　Vol. 5　No. 6　2020/03/03　Research paper (scientific journal)

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.

Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Megumi Naito, Takumi Yamaguchi, Lu Chen, Atsushi Kasai, Kaoru Seiriki, Takanobu Nakazawa, Shinsaku Nakagawa, Kenji Hashimoto, Hitoshi Hashimoto, Yukio Ago

Pharmacology, biochemistry, and behavior　Vol. 191　p. 172876-172876　2020/02/20　Research paper (scientific journal)

Autism-associated protein kinase D2 regulates embryonic cortical neuron development.

Kensuke Matsumura, Masayuki Baba, Kazuki Nagayasu, Kana Yamamoto, Momoka Kondo, Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Toshihiko Kuriu, Tokuichi Iguchi, Makoto Sato, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Biochemical and biophysical research communications　Vol. 519　No. 3　p. 626-632　2019/11/12　Research paper (scientific journal)

(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism.

Yukio Ago, Wataru Tanabe, Momoko Higuchi, Shinji Tsukada, Tatsunori Tanaka, Takumi Yamaguchi, Hisato Igarashi, Rei Yokoyama, Kaoru Seiriki, Atsushi Kasai, Takanobu Nakazawa, Shinsaku Nakagawa, Kenji Hashimoto, Hitoshi Hashimoto

The international journal of neuropsychopharmacology　Vol. 22　No. 10　p. 665-674　2019/10/01　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.

Atsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A Waschek, Hitoshi Hashimoto

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 39　No. 22　p. 4208-4220　2019/05/29　Research paper (scientific journal)

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism

Naoki Inoue, Sae Ogura, Atsushi Kasai, Takanobu Nakazawa, Kazuya Ikeda, Shintaro Higashi, Ayako Isotani, Kousuke Baba, Hideki Mochizuki, Harutoshi Fujimura, Yukio Ago, Atsuko Hayata-Takano, Kaoru Seiriki, Yusuke Shintani, Norihito Shintani, Hitoshi Hashimoto

EMBO Reports　Vol. 19　No. 3　2018/03/01　Research paper (scientific journal)

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

Yusuke Shintani, Atsuko Hayata-Takano, Keita Moriguchi, Takanobu Nakazawa, Yukio Ago, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Hitoshi Hashimoto

PloS one　Vol. 13　No. 5　2018　Research paper (scientific journal)

Simultaneous neuron- and astrocyte-specific fluorescent marking

Wiebke Schulze, Atsuko Hayata-Takano, Toshihiko Kamo, Takanobu Nakazawa, Kazuki Nagayasu, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Yukio Ago, Camille Farfan, Ryota Hashimoto, Akemichi Baba, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 459　No. 1　p. 81-86　2015/03　Research paper (scientific journal)

PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF

Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto

PLOS ONE　Vol. 10　No. 3　2015/03　Research paper (scientific journal)

A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

Sergey Malchenko, Simone Treiger Sredni, Hitoshi Hashimoto, Atsushi Kasai, Kazuki Nagayasu, Jianping Xie, Naira V. Margaryan, Kaoru Seiriki, Rishi R. Lulla, Richard E. B. Seftor, Lauren M. Pachman, Herbert Y. Meltzer, Mary J. C. Hendrix, Marcelo B. Soares

PLOS ONE　Vol. 10　No. 3　2015/03　Research paper (scientific journal)

[Pituitary adenylate cyclase-activating polypeptide(PACAP) plays significant roles in mental function and neuronal development].

Hayata-Takano A, Seiriki K, Tajiri M, Ogata K, Shintani N, Baba A, Hashimoto H

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology　Vol. 33　No. 2　p. 73-75　2013/04

Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons Therapeutic Implications for Psychiatric Disorders

Minako Tajiri, Atsuko Hayata-Takano, Kaoru Seiriki, Katsuya Ogata, Keisuke Hazama, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 48　No. 3　p. 473-481　2012/11　Research paper (scientific journal)