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Kai Toshie

甲斐 歳惠

Professor

Research History

  • 2021/04 - Present, Osaka University, Center for Global Initiatives, Director of Student Mobility Unit
  • 2015/10/01 - Present, Osaka University Graduate School of Frontier Biosciences Department of Frontier Biosciences, Professor
  • 2011/01 - 2015/09, The National University of Singapore, Department of Biological Science, Adjunct Associate Professor
  • 2010/10 - 2015/09, Temasek Lifesciences Laboratory, Senior Principal Investigator
  • 2007/02 - 2010/12, The National University of Singapore, Department of Biological Science, Adjunct Assistant Professor
  • 2005/06 - 2010/09, Temasek Lifesciences Laboratory, Principal Investigator
  • 2001/01 - 2005/06, Carnegie Institution of Washington/Howard Hughes Medical Institute, Department of Embryology, Research Associate
  • 2000/01 - 2001/12, Science and Technology Agency/Carnegie Institution of Washington, Department of Embryology, Long-term overseas researcher
  • 1999/10 - 1999/12, Carnegie Institution of Washington/Howard Hughes Medical Institute, Department of Embryology, Research Associate

Research Areas

  • Life sciences, Developmental biology
  • Life sciences, Molecular biology

Professional Memberships

  • 日本発生生物学会
  • 日本分子生物学会
  • 日本RNA学会

Papers

  • Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression, Shinichi Kawaguchi,Mizuki Ueki,Toshie Kai, PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 4, p. e0231114-e0231114, 2020/04/03
  • Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs During Sperm Maturation in Drosophila, Taichiro Iki,Moe Takami,Toshie Kai, Cell Reports, Elsevier BV, 2020
  • Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila, Ryan Yee Wei Teo,Amit Anand,Vishweshwaren Sridhar,Katsutomo Okamura,Toshie Kai, Nature Communications, Nature Publishing Group, Vol. 9, No. 1, 2018/12/01
  • Protecting and diversifying the germline, Ryan J. Gleason,Amit Anand,Toshie Kai,Xin Chen, Genetics, Genetics Society of America, Vol. 208, No. 2, p. 435-471, 2018/02/01
  • Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila, Teo Ryan Yee Wei,Anand Amit,Sridhar Vishweshwaren,Okamura Katsutomo,Kai Toshie, Nature communications, Nature Publishing Group, Vol. 9, No. 1, 2018
  • The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila, Emilie Quenerch'du,Amit Anand,Toshie Kai, RNA, COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, Vol. 22, No. 7, p. 1044-1054, 2016/07
  • 命をつないでいく生殖細胞:個体の生と死を越えて, 甲斐歳惠, 生産と技術, Vol. vol 68, No. 2, p. 101-104, 2016/04
  • A piece of the pi(e): The diverse roles of animal piRNAs and their PIWI partners, Robyn S. M. Lim,Toshie Kai, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 47-48, p. 17-31, 2015/12
  • The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster, Veena S. Patil,Amit Anand,Alisha Chakrabarti,Toshie Kai, BMC BIOLOGY, BIOMED CENTRAL LTD, Vol. 12, No. 1, p. 61-75, 2014/10
  • Response to Zhang et al, The EMBO Journal, 2014/03
  • Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway, Robyn S. M. Lim,Amit Anand,Chiemi Nishimiya-Fujisawa,Satoru Kobayashi,Toshie Kai, DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 386, No. 1, p. 237-251, 2014/02
  • Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila, Jun Wei Pek,Bing Fu Ng,Toshie Kai, DEVELOPMENT, COMPANY OF BIOLOGISTS LTD, Vol. 139, No. 24, p. 4505-4513, 2012/12
  • Isolation of Undifferentiated Female Germline Cells from Adult Drosophila Ovaries., Lim RS,Osato M,Kai T, Curr. Protoc. Stem Cell Biol., Vol. 34, p. 2E.3.1-2E.3.15, 2012/08
  • Tudor domain proteins in development, Jun Wei Pek,Amit Anand,Toshie Kai, DEVELOPMENT, COMPANY OF BIOLOGISTS LTD, Vol. 139, No. 13, p. 2255-2266, 2012/07
  • The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila, Amit Anand,Toshie Kai, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 31, No. 4, p. 870-882, 2012/02
  • piRNA pathway and the potential processing site, the nuage, in the Drosophila germline, Jun Wei Pek,Veena S. Patil,Toshie Kai, DEVELOPMENT GROWTH & DIFFERENTIATION, WILEY-BLACKWELL, Vol. 54, No. 1, p. 66-77, 2012/01
  • DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation, Jun Wei Pek,Toshie Kai, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 108, No. 29, p. 12007-12012, 2011/07
  • Non-coding RNAs enter mitosis: functions, conservation and implications, Jun Wei Pek,Toshie Kai, CELL DIVISION, BIOMED CENTRAL LTD, Vol. 6, No. 1, p. 6-11, 2011/02
  • A Role for Vasa in Regulating Mitotic Chromosome Condensation in Drosophila, Jun Wei Pek,Toshie Kai, CURRENT BIOLOGY, CELL PRESS, Vol. 21, No. 1, p. 39-44, 2011/01
  • Repression of Retroelements in Drosophila Germline via piRNA Pathway by the Tudor Domain Protein Tejas, Veena S. Patil,Toshie Kai, CURRENT BIOLOGY, CELL PRESS, Vol. 20, No. 8, p. 724-730, 2010/04
  • Drosophila Maelstrom Ensures Proper Germline Stem Cell Lineage Differentiation by Repressing microRNA-7, Jun Wei Pek,Ai Khim Lim,Toshie Kai, DEVELOPMENTAL CELL, CELL PRESS, Vol. 17, No. 3, p. 417-424, 2009/09
  • piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline, Ai Khim Lim,Liheng Tao,Toshie Kai, JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIV PRESS, Vol. 186, No. 3, p. 333-342, 2009/08
  • Conserved germline organelle, nuage, serves as site for processing of Piwi-interacting RNAs., Pek JW,Kai T, Experimental Medicine, Vol. 27, No. 3, p. 393-399, 2009/01
  • Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster, Ai Khim Lim,Toshie Kai, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 104, No. 16, p. 6714-6719, 2007/04
  • The expression profile of purified Drosophila germline stem cells, T Kai,D Williams,AC Spradling, DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 283, No. 2, p. 486-502, 2005/07
  • Germline stem cells and their niches., Kai T, Tanpakushitsu Kakusan Koso, Vol. 49, No. 6, p. 710-717, 2004/05
  • Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries, T Kai,A Spradling, NATURE, NATURE PUBLISHING GROUP, Vol. 428, No. 6982, p. 564-569, 2004/04
  • An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells, TS Kai,A Spradling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 100, No. 8, p. 4633-4638, 2003/04
  • Stem cells find their niche., Spradling A,Drummond-Barbosa D,Kai T, Nature, Vol. 414, No. 6859, p. 98-104, 2001/11

Misc.

  • Non-membranous RNP condensates control the fate of germline cells, 須山律子,甲斐歳惠, 実験医学, Vol. 39, No. 10, 2021
  • HP1a functions to suppress the evolutionarily fixed and telomeric transposons via piRNAs, Amit Anand,Teo Yee Wei,Katsutomo Okamura,Toshie Kai, GENES & GENETIC SYSTEMS, GENETICS SOC JAPAN, Vol. 91, No. 6, p. 331-331, 2016/12
  • Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin Response, Amit Anand,Toshie Kai, EMBO JOURNAL, WILEY-BLACKWELL, Vol. 33, No. 6, p. 540-541, 2014/03
  • Post-transcriptional retroelement surveillance is mediated by piRNAs in Drosophila germline, Ai Khim Lim,Liheng Tao,Toshie Kai, MECHANISMS OF DEVELOPMENT, ELSEVIER SCIENCE BV, Vol. 126, p. S51-S51, 2009/08

Presentations

  • piRNAs and PIWI proteins, EMBO Workshop
  • Tudor Domain Proteins and Small Interfering RNAs Protects Germline Cells, The International Conference of the Genetics Society of Korea 2017, 2017/10/27
  • HP1a は進化的に古いトランスポゾンとテロメア領域にある トランスポゾンをpiRNA 経路によって抑制する, 日本遺伝学会第88回大会, 2016/09/07
  • Nuage and piRNAs function for the safeguard of germline genome, Toshie Kai, 55th Annual Drosophila Research Conference, 2014/03/30
  • Nuage as a potential processing site of piRNAs in germline cells and stem cells, Emilie Quenerch'du,Robyn S. M. Lim,Amit Anand,Toshie Kai, 2013/07/25
  • Piwi proteins and piRNA function in Hydra stem cells, Asia-Pacific Developmental Biology Conference (APDBC 2012), 2012/10/08
  • Tudor Domain Proteins and Piwis Function in Nuage for piRNA Amplification in Stem Cells and Germline Cells, Amit Anand,Lim, Robyn S. m,Toshie Kai, ISSCR 2012, 2012/06/15
  • Nuage as a processing site of germline piRNA, Conference on Genome Engineering, 2011/06/20
  • Nuage: A Potential Site for Processing of Germline piRNA, Toshie Kai, 1st Asia-Pacific Drosophila Research Conference (APDRC), 2011/05/23
  • Nuage: A Potential Site for Processing of Germline piRNA, Toshie Kai, Keystone Symposia RNA silencing, 2011/03/23
  • International Symposium on Epigenetic Modifications of the Genome: Mechanisms and Implications, 13 ADNAT Convention
  • The biology of nuage: findings dropped from the clouds in germline cells, Toshie Kai, 2009
  • 第31回日本分子生物学会年会, 2008
  • シンガポール国立大学DBS, 2006
  • The symposium of Dynamics of Extracellular Environments, The symposium of Dynamics of Extracellular Environments, 2005