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Arai Masayoshi

荒井 雅吉

Professor

keyword Cancer,Infectious disease,Drug discovery,Chemical biology,Marine natural products

Research History

  • 2021/10 - Present, Osaka University, Graduate School of Pharmaceutical Sciences, Advanced Pharmaco-science, Professor
  • 2021/10 - Present, Osaka University, Laboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Professor

Research Areas

  • Life sciences, Bioorganic chemistry
  • Life sciences, Environmental and pharmaceutical development resources
  • Life sciences, Pharmaceuticals - chemistry and drug development

Professional Memberships

  • がん分子標的治療学会
  • 日本ケミカルバイオロジー学会
  • 日本生薬学会
  • 日本細菌学会
  • 日本薬学会

Papers

  • Asymmetric Formal Synthesis of Trichodermamides B and C, Atsushi Kimishima,Hayato Saito,Violeta Petrova,Masayoshi Arai, SYNLETT, GEORG THIEME VERLAG KG, 2021/07
  • Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald–Hartwig amination vs. aryne amination, Makito Yamada,Ryousuke Ohta,Kazuo Harada,Tsunayoshi Takehara,Hitoshi Haneoka,Yosuke Murakami,Takeyuki Suzuki,Yuuta Ohki,Naoyuki Takahashi,Toshiki Akiyama,Natchanun Sirimangkalakitti,Makoto Sako,Kenichi Murai,Masayoshi Arai,Mitsuhiro Arisawa, Green Chemistry, Royal Society of Chemistry (RSC), 2021
  • Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp., Waleed A. Abdel-Naime,Atsushi Kimishima,Andi Setiawan,John Refaat Fahim,Mostafa A. Fouad,Mohamed Salah Kamel,Masayoshi Arai, MARINE DRUGS, MDPI, Vol. 18, No. 11, 2020/11
  • Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation., Rui Tang,Dongyi Zhou,Atsushi Kimishima,Andi Setiawan,Masayoshi Arai, The Journal of antibiotics, 2020/06/25
  • 3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis., Yuji Sumii,Naoyuki Kotoku,Chisu Han,Kentaro Kamiya,Andi Setiawan,Catherine Vilchèze,William R Jacobs Jr,Masayoshi Arai, Tetrahedron letters, Vol. 61, No. 22, 2020/05/28
  • Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain, Masato Tanuma,Atsushi Kasai,Kazuki Bando,Naoyuki Kotoku,Kazuo Harada,Masafumi Minoshima,Kosuke Higashino,Atsushi Kimishima,Masayoshi Arai,Yukio Ago,Kaoru Seiriki,Kazuya Kikuchi,Satoshi Kawata,Katsumasa Fujita,Hitoshi Hashimoto, JCI Insight, 2020/03/03
  • Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation., Rui Tang,Atsushi Kimishima,Andi Setiawan,Masayoshi Arai, Journal of natural medicines, Vol. 74, No. 2, p. 495-500, 2020/03
  • A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines, Atsushi Kimishima,Hayato Saito,Ayuta Yamaguchi,Masayoshi Arai, TETRAHEDRON LETTERS, 2019/11
  • Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives., H. H,H. Mohammed,S. H. Abbas,El-Shimaa M,N. Abdelhafez,J. M. Berger,S. Mitarai,M. Arai,Gamal El-Din,A. A. Abuo-Rahma, Monatshefte für Chemie/Chemical Monthly, Vol. 150, No. 10, p. 1809-1824, 2019/09
  • Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation., R. Tang,A. Kimishima,R. Ishida,A. Setiawan,M. Arai, J. Nat. Med., 2019/08
  • Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger., T. Jomori,Y. Hara,M. Sasaoka,K. Harada,A. Setiawan,K. Hirata,A. Kimishima,M. Arai, J. Nat. Med., Springer-Nature, 2019/07
  • Cytotoxicity of new diterpene alkaloids, ceylonamides G-I, isolated from Indonesian marine sponge of Spongia sp., T. Jomori,A. Setiawan,M. Sasaoka,M. Arai, Nat. Prod. Commun., 2019/05
  • Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity., H.H.H. Mohammed,E.M.N. Abdelhafez,S.H. Abbas,G.A.I. Moustafa,G. Hauk,J.M. Berger,S. Mitarai,M. Arai,R.M. Abd,El-Baky,G.E.A. Abuo-Rahma, Bioorg. Chem., Vol. 88, 2019/04
  • Structural elucidation of glycosides from the seeds of Entada phaseoloides growing in Thua Thien Hue., L.C.V. Cuong,L.T. Lien,N.P.K. Nhi,T.P. Ha,L.T. Anh,M. Arai,H.L.T. Anh, Vietnam J. Sci. Technol., Vol. 57, No. 2, p. 170-178, 2019/04
  • Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression., S. Ueda,H. Ikeda,T. Namba,Y. Ikejiri,Y. Nishimoto,M. Arai,T. Nihira,S. Kitani, J. Ind. Microbiol. Biotechnol., Vol. 46, No. 5, p. 739-750, 2019/04
  • In vitro study on α-amylase inhibitory and α-glucosidase of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina., H.L.T. Anh,L.B. Vinh,L.T. Lien,P.V. Cuong,M. Arai,T.P. Ha,H.N. Lin,T.T.H. Dat,L.C.V. Cuong,Y.H. Kim, Nat. Prod. Res., p. 1-7, 2019/03
  • Target identification of the marine natural products dictyoceratin-A and -C as selective growth inhibitors in cancer cells adapted to hypoxic environments., T. Kawachi,S. Tanaka,A. Fukuda,Y. Sumii,A. Setiawan,N. Kotoku,M. Kobayashi,M. Arai, Mar. Drugs, Vol. 17, No. 3, 2019/03
  • Structure-activity relationship of biakamide, selective growth inhibitors under nutrient-starved condition from marine sponge., R. Ishida,H. Matsumoto,S. Ichii,M. Kobayashi,M. Arai,N. Kotoku, Chem. Pharm. Bull., Vol. 67, No. 3, p. 210-223, 2019/01
  • Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis., Ueda S,Kitani S,Namba T,Arai M,Ikeda H,Nihira T, J Antibiot (Tokyo)., Vol. 71, No. 10, p. 854-861, 2018/07
  • Characterization of the biosynthetic gene cluster for cryptic phthoxazolin a in streptomyces avermitilis, Dian Anggraini Suroto,Shigeru Kitani,Masayoshi Arai,Haruo Ikeda,Takuya Nihira, PLoS ONE, Public Library of Science, Vol. 13, No. 1, 2018/01/01
  • Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5., I.G.U. Pait,S. Kitani,F.W. Roslan,D. Ulanova,M. Arai,H. Ikeda,T. Nihira, Journal of Industrial Microbiology & Biotechnology, 2017/12
  • Activation of cryptic phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue AvaR3, Dian Anggraini Suroto,Shigeru Kitani,Kiyoko T. Miyamoto,Yasuko Sakihama,Masayoshi Arai,Haruo Ikeda,Takuya Nihira, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, SOC BIOSCIENCE BIOENGINEERING JAPAN, Vol. 124, No. 6, p. 611-617, 2017/12
  • 血管新生阻害活性を示す真菌由来ポリケチドおよび立体異性体の合成, 田村 理,荒井 雅吉,中村 友香,小林 資正,河野 富一, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 137年会, No. 2, p. 63-63, 2017/03
  • Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation, Naoyuki Kotoku,Ryosuke Ishida,Hirokazu Matsumoto,Masayoshi Arai,Kazunari Toda,Andi Setiawan,Osamu Muraoka,Motomasa Kobayashi, JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, Vol. 82, No. 3, p. 1705-1718, 2017/02
  • Anti-dormant mycobacterial activity of viomellein and xanthomegnin, naphthoquinone dimers produced by marine-derived Aspergillus sp., K. Kamiya,M. Arai,A. Setiawan,M. Kobayashi, Nat. Prod. Commun., 2017/01
  • Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II, Masayoshi Arai,Dayoung Shin,Kentaro Kamiya,Ryosuke Ishida,Andi Setiawan,Naoyuki Kotoku,Motomasa Kobayashi, JOURNAL OF NATURAL MEDICINES, SPRINGER JAPAN KK, Vol. 71, No. 1, p. 44-49, 2017/01
  • N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp., Masayoshi Arai,Kentaro Kamiya,Dayoung Shin,Hirokazu Matsumoto,Tomoya Hisa,Andi Setiawan,Naoyuki Kotoku,Motomasa Kobayashi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 64, No. 7, p. 766-771, 2016/07
  • Anti-dormant mycobacterial activity and target molecule of melophlins, tetramic acid derivatives isolated from a marine sponge of Melophlus sp., Masayoshi Arai,Yoshi Yamano,Kentaro Kamiya,Andi Setiawan,Motomasa Kobayashi, JOURNAL OF NATURAL MEDICINES, SPRINGER JAPAN KK, Vol. 70, No. 3, p. 467-475, 2016/07
  • Search for anti-angiogenic substances from natural sources, Naoyuki Kotoku,Masayoshi Arai,Motomasa Kobayashi, Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, Vol. 64, No. 2, p. 128-134, 2016/02/01
  • Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75, Masayoshi Arai,Takashi Kawachi,Naoyuki Kotoku,Chiaki Nakata,Haruhiko Kamada,Shin-ichi Tsunoda,Yasuo Tsutsumi,Hiroko Endo,Masahiro Inoue,Hiroki Sato,Motomasa Kobayashi, CHEMBIOCHEM, WILEY-V C H VERLAG GMBH, Vol. 17, No. 2, p. 181-189, 2016/01
  • Structure-Activity Relationship and in Vivo Anti-Tumor Evaluations of Dictyoceratin-A and -C, Hypoxia-Selective Growth Inhibitors from Marine Sponge, Yuji Sumii,Naoyuki Kotoku,Akinori Fukuda,Takashi Kawachi,Masayoshi Arai,Motomasa Kobayashi, MARINE DRUGS, MDPI AG, Vol. 13, No. 12, p. 7419-7432, 2015/12
  • Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp., Masayoshi Arai,Kentaro Kamiya,Patamaporn Pruksakorn,Yuji Sumii,Naoyuki Kotoku,Jean-Pierre Joubert,Prashini Moodley,Chisu Han,Dayoung Shin,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 23, No. 13, p. 3534-3541, 2015/07
  • Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge, Yuji Sumii,Naoyuki Kotoku,Akinori Fukuda,Takashi Kawachi,Yuta Sumii,Masayoshi Arai,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 23, No. 5, p. 966-975, 2015/03
  • Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner, Naoyuki Kotoku,Kenichi Higashimoto,Masatoshi Kurioka,Masayoshi Arai,Akinori Fukuda,Yuji Sumii,Yoshihiro Sowa,Toshiyuki Sakai,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 24, No. 15, p. 3389-3391, 2014/08
  • Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells, Masayoshi Arai,Takashi Kawachi,Hiroki Sato,Andi Setiawan,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 24, No. 14, p. 3155-3157, 2014/07
  • Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances, Masayoshi Arai,Chisu Han,Yoshi Yamano,Andi Setiawan,Motomasa Kobayashi, JOURNAL OF NATURAL MEDICINES, SPRINGER JAPAN KK, Vol. 68, No. 2, p. 372-376, 2014/04
  • Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor, Naoyuki Kotoku,Chiaki Nakata,Takashi Kawachi,Takanori Sato,Xiu-Han Guo,Aoi Ito,Yuji Sumii,Masayoshi Arai,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 22, No. 7, p. 2102-2112, 2014/04
  • Identification of the Target Protein of Agelasine D, a Marine Sponge Diterpene Alkaloid, as an Anti-dormant Mycobacterial Substance, Masayoshi Arai,Yoshi Yamano,Andi Setiawan,Motomasa Kobayashi, CHEMBIOCHEM, WILEY-V C H VERLAG GMBH, Vol. 15, No. 1, p. 117-123, 2014/01
  • An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses, Zhimin Li,Daisuke Shigeoka,Thomas R. Caulfield,Takashi Kawachi,Yushi Qiu,Takuma Kamon,Masayoshi Arai,Han W. Tun,Takehiko Yoshimitsu, MEDCHEMCOMM, ROYAL SOC CHEMISTRY, Vol. 4, No. 7, p. 1093-1098, 2013/07
  • Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species, Masayoshi Arai,Hiroki Niikawa,Motomasa Kobayashi, JOURNAL OF NATURAL MEDICINES, SPRINGER JAPAN KK, Vol. 67, No. 2, p. 271-275, 2013/04
  • Creation of Readily Accessible and Orally Active Analogue of Cortistatin A, Naoyuki Kotoku,Yuji Sumii,Takeshi Hayashi,Satoru Tamura,Takashi Kawachi,Sho Shiomura,Masayoshi Arai,Motomasa Kobayashi, ACS MEDICINAL CHEMISTRY LETTERS, AMER CHEMICAL SOC, Vol. 3, No. 8, p. 673-677, 2012/08
  • Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp., Yoshi Yamano,Masayoshi Arai,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 22, No. 14, p. 4877-4881, 2012/07
  • Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp., Masayoshi Arai,Yoshi Yamano,Mayumi Fujita,Andi Setiawan,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 22, No. 4, p. 1818-1821, 2012/02
  • P-30 Synthetic Studies and Biological Evaluation of Cortistatin A, an Anti-Angiogenic Steroidal Alkaloid from Marine Sponge, and Its Analogs(Poster Presentation), Sumii Yuji,Kotoku Naoyuki,Hayashi Takeshi,Tamura Satoru,Kawachi Takashi,Morimoto Kaoru,Arai Masayoshi,Kobayashi Motomasa, Symposium on the Chemistry of Natural Products, symposium papers, Symposium on the chemistry of natural products, No. 53, p. 571-576, 2011/09/02
  • Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge, Naoyuki Kotoku,Shinichi Fujioka,Chiaki Nakata,Masaki Yamada,Yuji Sumii,Takashi Kawachi,Masayoshi Arai,Motomasa Kobayashi, TETRAHEDRON, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 67, No. 35, p. 6673-6678, 2011/09
  • Action-Mechanism of Trichoderin A, an Anti-dormant Mycobacterial Aminolipopeptide from Marine Sponge-Derived Trichoderma sp., Patamaporn Pruksakorn,Masayoshi Arai,Liu Liu,Prashini Moodley,William Robert Jacobs,Motomasa Kobayashi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 34, No. 8, p. 1287-1290, 2011/08
  • DedA Protein Relates to Action-Mechanism of Halicyclamine A, a Marine Spongean Macrocyclic Alkaloid, as an Anti-dormant Mycobacterial Substance, Masayoshi Arai,Liu Liu,Takao Fujimoto,Andi Setiawan,Motomasa Kobayashi, MARINE DRUGS, MDPI AG, Vol. 9, No. 6, p. 984-993, 2011/06
  • Inhibitory Effect of Cyclic Trihydroxamate Siderophore, Desferrioxamine E, on the Biofilm Formation of Mycobacterium Species, Shunsuke Ishida,Masayoshi Arai,Hiroki Niikawa,Motomasa Kobayashi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 34, No. 6, p. 917-920, 2011/06
  • Anti-angiogenic effect of triterpenoidal saponins from Polygala senega, Masayoshi Arai,Asami Hayashi,Mari Sobou,Shunsuke Ishida,Takashi Kawachi,Naoyuki Kotoku,Motomasa Kobayashi, JOURNAL OF NATURAL MEDICINES, SPRINGER TOKYO, Vol. 65, No. 1, p. 149-156, 2011/01
  • Hypoxia-Selective Growth Inhibition of Cancer Cells by Furospinosulin-1, a Furanosesterterpene Isolated from an Indonesian Marine Sponge, Masayoshi Arai,Takashi Kawachi,Andi Setiawan,Motomasa Kobayashi, CHEMMEDCHEM, WILEY-V C H VERLAG GMBH, Vol. 5, No. 11, p. 1919-1926, 2010/11
  • Studies on Analogue Synthesis and Action-mechanism of Furospinosulin-1, Hypoxia-selective Growth Inhibitor from Marine Sponge, Kotoku Naoyuki,Arai Masayoshi,Kawachi Takashi,Fujioka Shinichi,Nakata Chiaki,Yamada Masaki,Kobayashi Motomasa, Symposium on the Chemistry of Natural Products, symposium papers, Symposium on the chemistry of natural products, No. 52, p. 355-360, 2010/09/01
  • Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity, Naoyuki Kotoku,Xiu-Han Guo,Masayoshi Arai,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 20, No. 14, p. 4152-4155, 2010/07
  • Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria, Patamaporn Pruksakorn,Masayoshi Arai,Naoyuki Kotoku,Catherine Vilcheze,Anthony D. Baughn,Prashini Moodley,William R. Jacobs,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 20, No. 12, p. 3658-3663, 2010/06
  • Haliclonacyclamines, Tetracyclic Alkylpiperidine Alkaloids, as Anti-dormant Mycobacterial Substances from a Marine Sponge of Haliclona sp., Masayoshi Arai,Shunsuke Ishida,Andi Settawan,Motomasa Kobayashi, CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 57, No. 10, p. 1136-1138, 2009/10
  • Hypoxia selective cytotoxicity of furospinosulin-1 from Indonesian marine sponge, Arai Masayoshi,Kawachi Takashi,Kotoku Naoyuki,Sumii Yuji,Fujioka Shinichi,Kobayashi Motomasa, Symposium on the Chemistry of Natural Products, symposium papers, Symposium on the chemistry of natural products, No. 51, p. 647-652, 2009/09/01
  • Pyripyropenes, Fungal Sesquiterpenes Conjugated with alpha-Pyrone and Pyridine Moieties, Exhibits Anti-angiogenic Activity against Human Umbilical Vein Endothelial Cells, Asami Hayashi,Masayoshi Arai,Mayumi Fujita,Motomasa Kobayashi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 32, No. 7, p. 1261-1265, 2009/07
  • Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death, Hideaki Suna,Masayoshi Arai,Yoshie Tsubotani,Asami Hayashi,Andi Setiawan,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 17, No. 11, p. 3968-3972, 2009/06
  • Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent, Masayoshi Arai,Mari Sobou,Catherine Vilcheze,Anthony Baughn,Hiroyuki Hashizume,Patamaporn Pruksakorn,Shunsuke Ishida,Makoto Matsumoto,William R. Jacobs,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 16, No. 14, p. 6732-6736, 2008/07
  • Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids, Shunji Aoki,Yasuo Watanabe,Daiki Tanabe,Masayoshi Arai,Hideaki Suna,Katsushiro Miyamoto,Hiroshi Tsujibo,Kazutake Tsujikawa,Hiroshi Yamamoto,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 15, No. 21, p. 6758-6762, 2007/11
  • Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived fungus Aspergillus candidus IF10, Hong Wei,Hirohiko Inada,Asarni Hayashi,Kenichi Higashimoto,Patamaporn Pruksakorn,Sayo Kamada,Masayoshi Arai,Shunsuke Ishida,Motomasa Kobayashi, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOC, Vol. 60, No. 9, p. 586-590, 2007/09
  • Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata, Shunji Aoki,Mami Sanagawa,Yasuo Watanabe,Andi Setiawan,Masayoshi Arai,Motomasa Kobayashi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 15, No. 14, p. 4818-4828, 2007/07
  • Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171, Masato Iwatsuki,Ryuji Uchida,Yoichi Takakusagi,Atsuko Matsumoto,Cheng-Lin Jiang,Yoko Takahashi,Masayoshi Arai,Susumu Kobayashi,Makoto Matsumoto,Junji Inokoshi,Hiroshi Tomoda,Satoshi Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOC, Vol. 60, No. 6, p. 357-363, 2007/06
  • Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex, Shunji Aoki,Yasuo Watanabe,Daiki Tanabe,Andi Setiawan,Masayoshi Arai,Motomasa Kobayashi, TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 48, No. 26, p. 4485-4488, 2007/06
  • Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli, Oren Zimhony,Catherine Vilcheze,Masayoshi Arai,John T. Welch,William R. Jacobs, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMER SOC MICROBIOLOGY, Vol. 51, No. 2, p. 752-754, 2007/02
  • Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid, Catherine Vilcheze,Feng Wang,Masayoshi Arai,Manzour Hernando Hazbon,Roberto Colangeli,Laurent Kremer,Torin R. Weisbrod,David Alland,James C. Sacchettini,William R. Jacobs, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 12, No. 9, p. 1027-1029, 2006/09
  • Boromycin abrogates bleomycin-induced G2 checkpoint, M Arai,Y Koizumi,H Sato,T Kawabe,M Suganuma,H Kobayashi,H Tomada,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOC, Vol. 57, No. 10, p. 662-668, 2004/10
  • Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization., Yukio Koizumi,Masayoshi Arai,Hiroshi Tomoda,Satoshi Omura, Biochimica et biophysica acta, Vol. 1693, No. 1, p. 47-55, 2004/07/23
  • Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization, Y Koizumi,M Arai,H Tomoda,S Omura, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE BV, Vol. 1693, No. 1, p. 47-55, 2004/07
  • Analysis of the mechanism of anti-mycotic activities by azoles potentiated by new erythromycin derivatives., Omura S,Arai M,Sato K,Nagamitsu T,Nagai K,Sunazuka T,Tomoda H, Jpn. J. Antibiot., Japan Antibiotics Research Association, Vol. 57, No. Suppl A, p. 96-100, 2004/06
  • Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin alpha, M Arai,H Sato,H Kobayashi,M Suganuma,T Kawabe,H Tomoda,S Omura, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 317, No. 3, p. 817-822, 2004/05
  • New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 - II. Structure elucidation., T Fukuda,M Arai,H Tomoda,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 57, No. 2, p. 117-124, 2004/02
  • New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 - I. Taxonomy, fermentation, isolation and biological properties, T Fukuda,M Arai,Y Yamaguchi,R Masuma,H Tomoda,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 57, No. 2, p. 110-116, 2004/02
  • Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization, Yukio Koizumi,Masayoshi Arai,Hiroshi Tomoda,Satoshi Omura, Journal of Antibiotics, Japan Antibiotics Research Association, Vol. 57, No. 7, p. 415-420, 2004
  • Structure elucidation of new monordens produced by Humicola sp FO-2942, K Yamamoto,H Hatano,M Arai,K Shiomi,H Tomoda,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 56, No. 6, p. 533-538, 2003/06
  • New monordens produced by amidepsine-producing fungus Humicola sp FO-2942, M Arai,K Yamamoto,Namatame, I,H Tomoda,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 56, No. 6, p. 526-532, 2003/06
  • Purification of Shiga-like toxin 1 by pigeon egg white glycoproteins immobilized on Sepharose gels, H Tomoda,M Arai,N Koyama,H Matsui,S Omura,R Obata,YC Lee, ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 311, No. 1, p. 50-56, 2002/12
  • Phoma sp. FOM-8108, a producer of gentisylquinones, isolated from sea sand, Yuichi Yamaguchi,Rokuro Masuma,Ryuji Uchida,Masayoshi Arai,Hiroshi Tomoda,Satoshi Omura, Mycoscience, Springer Japan, Vol. 43, No. 2, p. 127-133, 2002/04/25
  • Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076, M Arai,H Tomoda,T Okuda,HY Wang,N Tabata,R Masuma,Y Yamaguchi,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 55, No. 2, p. 172-180, 2002/02
  • Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus, R Uchida,H Tomoda,M Arai,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 54, No. 11, p. 882-889, 2001/11
  • Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp WK-6326 - II. Structure elucidation, M Arai,H Tomoda,N Tabata,N Ishiguro,S Kobayashi,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 54, No. 7, p. 562-566, 2001/07
  • Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp WK-6326 - I. Taxonomy, fermentation, isolation and biological activities, M Arai,H Tomoda,A Matsumoto,Y Takahashi,BH Woodruff,N Ishiguro,S Kobayashi,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 54, No. 7, p. 554-561, 2001/07
  • Effect of fungal metabolites cytochalasans on lipid droplet formation in mouse macrophages, Namatame, I,H Tomoda,M Arai,S Omura, JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOT RES ASSN, Vol. 53, No. 1, p. 19-25, 2000/01
  • Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway, K Nomura,H Imai,T Koumura,M Arai,Y Nakagawa, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 274, No. 41, p. 29294-29302, 1999/10
  • Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages, N Chiba,H Imai,K Narashima,M Arai,G Oshima,M Kunimoto,Y Nakagawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 22, No. 10, p. 1047-1051, 1999/10
  • Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells, M Arai,H Imai,T Koumura,M Yoshida,K Emoto,M Umeda,N Chiba,Y Nakagawa, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 274, No. 8, p. 4924-4933, 1999/02
  • Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase, H Imai,K Narashima,M Arai,H Sakamoto,N Chiba,Y Nakagawa, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 273, No. 4, p. 1990-1997, 1998/01
  • Preferential esterification of endogenously formed 5-hydroxyeicosatetraenoic acid to phospholipids in activated polymorphonuclear leukocytes, M Arai,H Imai,A Metori,Y Nakagawa, EUROPEAN JOURNAL OF BIOCHEMISTRY, SPRINGER VERLAG, Vol. 244, No. 2, p. 513-519, 1997/03
  • Import into mitochondria of phospholipid hydroperoxide glutathione peroxidase requires a leader sequence, M Arai,H Imai,D Sumi,T Imanaka,T Takano,N Chiba,Y Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, Vol. 227, No. 2, p. 433-439, 1996/10
  • Overexpression of phospholipid hydroperoxide glutathione peroxidase suppressed cell death due to oxidative damage in rat basophile leukemia cells (RBL-2H3), H Imai,D Sumi,H Sakamoto,A Hanamoto,M Arai,N Chiba,Y Nakagawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 222, No. 2, p. 432-438, 1996/05
  • Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression., Imai H,Sumi D,Hanamoto A,Arai M,Sugiyama A,Chiba N,Kuchino Y,Nakagawa Y, J. Biochem., OXFORD JOURNALS, Vol. 118(5), 1061-1067., 1995/07

Misc.

  • Synthesis of cis-epoxide relatives of antiangiogenetic novel butenolide, 田村理,佐藤圭悟,廣田ゆい,藤原麗菜,山崎未稀,菅井滉太,吉田有毅,荒井雅吉,中村友香,小林資正,河野富一, 日本薬学会年会要旨集(CD-ROM), Vol. 140th (Web), 2020
  • 海洋真菌由来血管新生阻害ブテノリドの立体異性体を用いた構造活性相関, 田村理,吉田有毅,荒井雅吉,中村友香,廣田ゆい,藤原麗菜,小林資正,河野富一, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 99th, 2019
  • 血管新生阻害活性を示す海洋真菌由来新規ブテノライド, 田村理,吉田有毅,荒井雅吉,中村友香,小林資正,河野富一, 日本生薬学会年会講演要旨集, Vol. 66th, 2019
  • 血管新生阻害活性を示す海洋真菌由来新規ブテノリドの合成研究, 田村理,吉田有毅,廣田ゆい,藤原麗菜,荒井雅吉,中村友香,佐藤圭悟,小林資正,河野富一, 日本薬学会東北支部大会講演要旨集, Vol. 58th, 2019
  • Exploring new drug targets through the identification of target molecules of bioactive natural products, Masayoshi Arai, Yakugaku Zasshi, Pharmaceutical Society of Japan, Vol. 136, No. 4, p. 669-676, 2016/04/01
  • Search for New Medicinal Seed and Identification of Target Molecule on the Basis of Phenotypic Screening, Masayoshi Arai, Yakugaku Zasshi, 2015/11
  • Novel Polyketides as Selective Growth Inhibitors against Cancer Cells under Glucose-deprived Condition, Kotoku Naoyuki,Toda Kazunari,Arai Masayoshi,Ishida Ryosuke,Matsumoto Hirokazu,Muraoka Osamu,Kobayashi Motomasa, Symposium on the Chemistry of Natural Products, symposium papers, Symposium on the Chemistry of Natural Products Steering Committee, Vol. 56, No. 0, 2014
  • Search for medicinal seeds from marine organisms, Masayoshi Arai,Motomasa Kobayashi, Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Journal of Synthetic Organic Chemistry, Japan, Vol. 68, No. 5, p. 470-479, 2010/05
  • 海洋天然物のケミカルバイオロジー, 荒井雅吉,小林資正, 化学と生物, 日本農芸化学会, Vol. 47(4), 275-282, No. 6, p. 404-405, 2009/01
  • 血管新生を標的とする新しい抗がん剤, 荒井雅吉,小林資正, 化学, 化学同人, Vol. 63(10),72-73, 2008/01

Publications

  • Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules, Masayoshi Arai, Springer, 2019/04
  • アルカロイドの科学「創薬、生命科学に貢献したアルカロイドのケミカルバイオロジー」, 高山廣光,編,荒井雅吉,小林資正, 化学同人, 2017/09