Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function

Fumie Mitani, Jianyu Lin, Tatsuya Sakamoto, Ryo Uehara, Tomoya Hikita, Takuya Yoshida, Andi Setiawan, Masayoshi Arai, Chitose Oneyama

Scientific Reports　Vol. 12　No. 1　2022/12　Research paper (scientific journal)

Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues

Makito Yamada, Yu Hirose, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Sirimangkalakitti Natchanun, Naoyuki Takahashi, Yuuta Ohki, Makoto Sako, Kenichi Murai, Kazuo Harada, Masayoshi Arai, Sayo Suzuki, Tomonori Nakamura, Junichi Haruta, Mitsuhiro Arisawa

ACS Medicinal Chemistry Letters　2022/08/22　Research paper (scientific journal)

Gamma-Glutamylcysteine Production Using Phytochelatin Synthase-Like Enzyme Derived from <i>Nostoc</i> sp. Covalently Immobilized on a Cellulose Carrier

Misa Muraoka, Moeka Ohno, Takuya Nakai, Hideyuki Matsuura, Kazuya Nagano, Masayoshi Arai, Yoshihiko Hirata, Hiroshi Uyama, Kazumasa Hirata

Biological and Pharmaceutical Bulletin　Vol. 45　No. 8　p. 1191-1197　2022/08/01　Research paper (scientific journal)

Antifungal Agent Chitooligosaccharides Derived from Solid-State Fermentation of Shrimp Shell Waste by Pseudonocardia antitumoralis 18D36-A1

Widyastuti Widyastuti, Fendi Setiawan, Chasya Al Afandy, Arik Irawan, Aspita Laila, Ni Luh Gede Ratna Juliasih, Wawan Abdullah Setiawan, Masayoshi Arai, John Hendri, Andi Setiawan

Fermentation　Vol. 8　No. 8　p. 353-353　2022/07/26　Research paper (scientific journal)

Single-step construction of an acetoxypyrroloindole skeleton via tandem iodocyclization/acetoxylation of indoles

Atsushi Kimishima, Hiroki Kato, Keijin Nakaguro, Masayoshi Arai

Organic & Biomolecular Chemistry　2022/07　Research paper (scientific journal)

Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.

Kenta Ikoma, Michihiro Takahama, Atsushi Kimishima, Yixi Pan, Manabu Taura, Akiyoshi Nakayama, Masayoshi Arai, Naoki Takemura, Tatsuya Saitoh

International immunology　2022/05/27　Research paper (scientific journal)

Fungicide Activity of Culture Extract from Kocuria palustris 19C38A1 against Fusarium oxysporum

Andi Setiawan, Fendi Setiawan, Ni Luh Gede Ratna Juliasih, Widyastuti Widyastuti, Aspita Laila, Wawan A. Setiawan, Fernandy M. Djailani, Mulyono Mulyono, John Hendri, Masayoshi Arai

Journal of Fungi　Vol. 8　No. 3　p. 280-280　2022/03/09　Research paper (scientific journal)

Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A-D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells.

Tadafumi Fujita, Jianyu Lin, Atsushi Kimishima, Masayoshi Arai, Hirosato Takikawa, Yusuke Ogura

Bioscience, biotechnology, and biochemistry　2022/02/14　Research paper (scientific journal)

Study of the Structure-Activity Relationship of an Anti-Dormant Mycobacterial Substance 3-(Phenethylamino)Demethyl(oxy)aaptamine to Create a Probe Molecule for Detecting Its Target Protein.

Yuji Sumii, Kentaro Kamiya, Takehiko Nakamura, Kenta Tanaka, Takumi Kaji, Junya Mukomura, Naoyuki Kotoku, Masayoshi Arai

Marine drugs　Vol. 20　No. 2　p. 98-98　2022/01/24　Research paper (scientific journal)

Reactivity of γ‐glutamyl‐cysteine with intracellular and extracellular glutathione metabolic enzymes

Misa Muraoka, Saki Yoshida, Moeka Ohno, Hideyuki Matsuura, Kazuya Nagano, Yoshihiko Hirata, Masayoshi Arai, Kazumasa Hirata

FEBS Letters　Vol. 596　No. 2　p. 180-188　2022/01　Research paper (scientific journal)

Solid State Fermentation of Shrimp Shell Waste Using Pseudonocardia carboxydivorans 18A13O1 to Produce Bioactive Metabolites

Andi Setiawan, Widyastuti Widyastuti, Arik Irawan, Oklis Syahrin Wijaya, Aspita Laila, Wawan Abdullah Setiawan, Ni Luh Gede Ratna Juliasih, Kenichi Nonaka, Masayoshi Arai, John Hendri

Fermentation　Vol. 7　No. 4　p. 247-247　2021/10/29　Research paper (scientific journal)

Asymmetric Formal Synthesis of Trichodermamides B and C

Atsushi Kimishima, Hayato Saito, Violeta Petrova, Masayoshi Arai

SYNLETT　2021/07　Research paper (scientific journal)

Correction to: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation (Journal of Natural Medicines, (2020), 74, 1, (153-158), 10.1007/s11418-019-01357-w)

Rui Tang, Atsushi Kimishima, Ryosuke Ishida, Andi Setiawan, Masayoshi Arai

Journal of Natural Medicines　Vol. 75　No. 3　2021/06/01　Research paper (scientific journal)

Fasciospyrinadinone and fasciospyrinadinol, novel 3-alkylpyridine sesquiterpenoids from an Indonesian marine sponge, as selective growth inhibitors of the cancer cells under nutrient starvation

Hirokazu Matsumoto, Tomoya Hisa, Kazunari Toda, Ryosuke Ishida, Andi Setiawan, Masayoshi Arai, Naoyuki Kotoku

Heterocycles　Vol. 103　No. 2　2021　Research paper (scientific journal)

Inhibitory Activity and Proposed Binding Model of γ-Glutamyl Cysteine, the Precursor of Glutathione, on Angiotensin Converting Enzyme

Chisato Okajima, Naoki Imakawa, Kazuya Nagano, Masayoshi Arai, Mitsuhiro Arisawa, Misa Muraoka, Hirofumi Tsujino, Yoshihiko Hirata, Kazumasa Hirata

BPB Reports　Vol. 4　No. 4　p. 116-119　2021　Research paper (scientific journal)

Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald–Hartwig amination vs. aryne amination

Makito Yamada, Ryousuke Ohta, Kazuo Harada, Tsunayoshi Takehara, Hitoshi Haneoka, Yosuke Murakami, Takeyuki Suzuki, Yuuta Ohki, Naoyuki Takahashi, Toshiki Akiyama, Natchanun Sirimangkalakitti, Makoto Sako, Kenichi Murai, Masayoshi Arai, Mitsuhiro Arisawa

Green Chemistry　2021　Research paper (scientific journal)

Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.

Waleed A. Abdel-Naime, Atsushi Kimishima, Andi Setiawan, John Refaat Fahim, Mostafa A. Fouad, Mohamed Salah Kamel, Masayoshi Arai

MARINE DRUGS　Vol. 18　No. 11　2020/11　Research paper (scientific journal)

Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation.

Rui Tang, Dongyi Zhou, Atsushi Kimishima, Andi Setiawan, Masayoshi Arai

The Journal of antibiotics　2020/06/25　Research paper (scientific journal)

3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis.

Yuji Sumii, Naoyuki Kotoku, Chisu Han, Kentaro Kamiya, Andi Setiawan, Catherine Vilchèze, William R Jacobs Jr, Masayoshi Arai

Tetrahedron letters　Vol. 61　No. 22　2020/05/28　Research paper (scientific journal)

Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain

Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto

JCI Insight　2020/03/03　Research paper (scientific journal)

Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation.

Rui Tang, Atsushi Kimishima, Andi Setiawan, Masayoshi Arai

Journal of natural medicines　Vol. 74　No. 2　p. 495-500　2020/03

Cytotoxic Activity of Abietane-Type Diterpenes Isolated From Taxodium distichum Against Cancer Cells Adapted to Nutrient-Starved Conditions

Ahmed M. Zaher, Jianyu Lin, Masayoshi Arai

Natural Product Communications　Vol. 15　No. 3　2020　Research paper (scientific journal)

Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger

Takahiro Jomori, Yasumasa Hara, Miho Sasaoka, Kazuo Harada, Andi Setiawan, Kazumasa Hirata, Atsushi Kimishima, Masayoshi Arai

JOURNAL OF NATURAL MEDICINES　Vol. 74　No. 1　p. 76-82　2020/01　Research paper (scientific journal)

A stereoselective construction of a cis-1,2-oxazadecaline skeleton using a substrate-controlled intramolecular oxy-Michael addition of tyrosine-derived hydroxylamines

Atsushi Kimishima, Hayato Saito, Ayuta Yamaguchi, Masayoshi Arai

TETRAHEDRON LETTERS　2019/11

Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives.

H. H, H. Mohammed, S. H. Abbas, El-Shimaa M, N. Abdelhafez, J. M. Berger, S. Mitarai, M. Arai, Gamal El-Din, A. A. Abuo-Rahma

Monatshefte für Chemie/Chemical Monthly　Vol. 150　No. 10　p. 1809-1824　2019/09　Research paper (scientific journal)

Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.

R. Tang, A. Kimishima, R. Ishida, A. Setiawan, M. Arai

J. Nat. Med.　2019/08　Research paper (scientific journal)

Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger.

T. Jomori, Y. Hara, M. Sasaoka, K. Harada, A. Setiawan, K. Hirata, A. Kimishima, M. Arai

J. Nat. Med.　2019/07　Research paper (scientific journal)

Cytotoxicity of new diterpene alkaloids, ceylonamides G-I, isolated from Indonesian marine sponge of Spongia sp.

T. Jomori, A. Setiawan, M. Sasaoka, M. Arai

Nat. Prod. Commun.　2019/05　Research paper (scientific journal)

Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity.

H.H.H. Mohammed, E.M.N. Abdelhafez, S.H. Abbas, G.A.I. Moustafa, G. Hauk, J.M. Berger, S. Mitarai, M. Arai, R.M. Abd, El-Baky, G.E.A. Abuo-Rahma

Bioorg. Chem.　Vol. 88　2019/04　Research paper (scientific journal)

Structural elucidation of glycosides from the seeds of Entada phaseoloides growing in Thua Thien Hue.

L.C.V. Cuong, L.T. Lien, N.P.K. Nhi, T.P. Ha, L.T. Anh, M. Arai, H.L.T. Anh

Vietnam J. Sci. Technol.　Vol. 57　No. 2　p. 170-178　2019/04　Research paper (scientific journal)

Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression.

S. Ueda, H. Ikeda, T. Namba, Y. Ikejiri, Y. Nishimoto, M. Arai, T. Nihira, S. Kitani

J. Ind. Microbiol. Biotechnol.　Vol. 46　No. 5　p. 739-750　2019/04　Research paper (scientific journal)

In vitro study on α-amylase inhibitory and α-glucosidase of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina.

H.L.T. Anh, L.B. Vinh, L.T. Lien, P.V. Cuong, M. Arai, T.P. Ha, H.N. Lin, T.T.H. Dat, L.C.V. Cuong, Y.H. Kim

Nat. Prod. Res.　p. 1-7　2019/03　Research paper (scientific journal)

Target identification of the marine natural products dictyoceratin-A and -C as selective growth inhibitors in cancer cells adapted to hypoxic environments.

T. Kawachi, S. Tanaka, A. Fukuda, Y. Sumii, A. Setiawan, N. Kotoku, M. Kobayashi, M. Arai

Mar. Drugs　Vol. 17　No. 3　2019/03　Research paper (scientific journal)

Structure-activity relationship of biakamide, selective growth inhibitors under nutrient-starved condition from marine sponge.

R. Ishida, H. Matsumoto, S. Ichii, M. Kobayashi, M. Arai, N. Kotoku

Chem. Pharm. Bull.　Vol. 67　No. 3　p. 210-223　2019/01　Research paper (scientific journal)

Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis.

Ueda S, Kitani S, Namba T, Arai M, Ikeda H, Nihira T

J Antibiot (Tokyo).　Vol. 71　No. 10　p. 854-861　2018/07　Research paper (scientific journal)

Design, synthesis, molecular docking and antimicrobial activity of New 7-(4-(2-((1,2,4-triazol-3-yl)thio)acetyl)piperazin-1-yl) derivatives of ciprofloxacin

Mohammed Hamada, Abdelhafez El-Shimaa, Abbas Samar, Abuo-Rahma Gamal El-Din, Hauk Glenn, Berger James, Mitarai Satoshi, Arai Masayoshi, Dalby Kevin, Kaoud Tamer

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　Vol. 255　2018/03　Research paper (scientific journal)

Characterization of the biosynthetic gene cluster for cryptic phthoxazolin a in streptomyces avermitilis

Dian Anggraini Suroto, Shigeru Kitani, Masayoshi Arai, Haruo Ikeda, Takuya Nihira

PLoS ONE　Vol. 13　No. 1　2018/01/01　Research paper (scientific journal)

Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.

I.G.U. Pait, S. Kitani, F.W. Roslan, D. Ulanova, M. Arai, H. Ikeda, T. Nihira

Journal of Industrial Microbiology & Biotechnology　2017/12　Research paper (scientific journal)

Activation of cryptic phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue AvaR3

Dian Anggraini Suroto, Shigeru Kitani, Kiyoko T. Miyamoto, Yasuko Sakihama, Masayoshi Arai, Haruo Ikeda, Takuya Nihira

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　Vol. 124　No. 6　p. 611-617　2017/12　Research paper (scientific journal)

Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation

Naoyuki Kotoku, Ryosuke Ishida, Hirokazu Matsumoto, Masayoshi Arai, Kazunari Toda, Andi Setiawan, Osamu Muraoka, Motomasa Kobayashi

JOURNAL OF ORGANIC CHEMISTRY　Vol. 82　No. 3　p. 1705-1718　2017/02　Research paper (scientific journal)

Anti-dormant mycobacterial activity of viomellein and xanthomegnin, naphthoquinone dimers produced by marine-derived Aspergillus sp.

K. Kamiya, M. Arai, A. Setiawan, M. Kobayashi

Nat. Prod. Commun.　2017/01　Research paper (scientific journal)

Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II

Masayoshi Arai, Dayoung Shin, Kentaro Kamiya, Ryosuke Ishida, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi

JOURNAL OF NATURAL MEDICINES　Vol. 71　No. 1　p. 44-49　2017/01　Research paper (scientific journal)

N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.

Masayoshi Arai, Kentaro Kamiya, Dayoung Shin, Hirokazu Matsumoto, Tomoya Hisa, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 64　No. 7　p. 766-771　2016/07　Research paper (scientific journal)

Anti-dormant mycobacterial activity and target molecule of melophlins, tetramic acid derivatives isolated from a marine sponge of Melophlus sp.

Masayoshi Arai, Yoshi Yamano, Kentaro Kamiya, Andi Setiawan, Motomasa Kobayashi

JOURNAL OF NATURAL MEDICINES　Vol. 70　No. 3　p. 467-475　2016/07　Research paper (scientific journal)

Search for anti-angiogenic substances from natural sources

Naoyuki Kotoku, Masayoshi Arai, Motomasa Kobayashi

Chemical and Pharmaceutical Bulletin　Vol. 64　No. 2　p. 128-134　2016/02/01

Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75

Masayoshi Arai, Takashi Kawachi, Naoyuki Kotoku, Chiaki Nakata, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi, Hiroko Endo, Masahiro Inoue, Hiroki Sato, Motomasa Kobayashi

CHEMBIOCHEM　Vol. 17　No. 2　p. 181-189　2016/01　Research paper (scientific journal)

Structure-Activity Relationship and in Vivo Anti-Tumor Evaluations of Dictyoceratin-A and -C, Hypoxia-Selective Growth Inhibitors from Marine Sponge

Yuji Sumii, Naoyuki Kotoku, Akinori Fukuda, Takashi Kawachi, Masayoshi Arai, Motomasa Kobayashi

MARINE DRUGS　Vol. 13　No. 12　p. 7419-7432　2015/12　Research paper (scientific journal)

Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.

Masayoshi Arai, Kentaro Kamiya, Patamaporn Pruksakorn, Yuji Sumii, Naoyuki Kotoku, Jean-Pierre Joubert, Prashini Moodley, Chisu Han, Dayoung Shin, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 23　No. 13　p. 3534-3541　2015/07　Research paper (scientific journal)

Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge

Yuji Sumii, Naoyuki Kotoku, Akinori Fukuda, Takashi Kawachi, Yuta Sumii, Masayoshi Arai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 23　No. 5　p. 966-975　2015/03　Research paper (scientific journal)

Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner

Naoyuki Kotoku, Kenichi Higashimoto, Masatoshi Kurioka, Masayoshi Arai, Akinori Fukuda, Yuji Sumii, Yoshihiro Sowa, Toshiyuki Sakai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 24　No. 15　p. 3389-3391　2014/08　Research paper (scientific journal)

Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells

Masayoshi Arai, Takashi Kawachi, Hiroki Sato, Andi Setiawan, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 24　No. 14　p. 3155-3157　2014/07　Research paper (scientific journal)

Enantiospecific Synthesis and Cytotoxicity Evaluation of Ligudentatol: A Programmed Aromatization Approach to the 2,3,4-Trisubstituted Phenolic Motif via Visible-Light-Mediated Group Transfer Radical Cyclization

Gamal A. I. Moustafa, Hiroshi Suizu, Hiroshi Aoyama, Masayoshi Arai, Shuji Akai, Takehiko Yoshimitsu

CHEMISTRY-AN ASIAN JOURNAL　Vol. 9　No. 6　p. 1506-1510　2014/06　Research paper (scientific journal)

Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances

Masayoshi Arai, Chisu Han, Yoshi Yamano, Andi Setiawan, Motomasa Kobayashi

JOURNAL OF NATURAL MEDICINES　Vol. 68　No. 2　p. 372-376　2014/04　Research paper (scientific journal)

Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor

Naoyuki Kotoku, Chiaki Nakata, Takashi Kawachi, Takanori Sato, Xiu-Han Guo, Aoi Ito, Yuji Sumii, Masayoshi Arai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 22　No. 7　p. 2102-2112　2014/04　Research paper (scientific journal)

Identification of the Target Protein of Agelasine D, a Marine Sponge Diterpene Alkaloid, as an Anti-dormant Mycobacterial Substance

Masayoshi Arai, Yoshi Yamano, Andi Setiawan, Motomasa Kobayashi

CHEMBIOCHEM　Vol. 15　No. 1　p. 117-123　2014/01　Research paper (scientific journal)

An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses

Zhimin Li, Daisuke Shigeoka, Thomas R. Caulfield, Takashi Kawachi, Yushi Qiu, Takuma Kamon, Masayoshi Arai, Han W. Tun, Takehiko Yoshimitsu

MEDCHEMCOMM　Vol. 4　No. 7　p. 1093-1098　2013/07　Research paper (scientific journal)

Potent growth inhibitory activity of (+/-)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis

Gamal A. I. Moustafa, Shoji Nojima, Yoshi Yamano, Akio Aono, Masayoshi Arai, Satoshi Mitarai, Tetsuaki Tanaka, Takehiko Yoshimitsu

MEDCHEMCOMM　Vol. 4　No. 4　p. 720-723　2013/04　Research paper (scientific journal)

Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species

Masayoshi Arai, Hiroki Niikawa, Motomasa Kobayashi

JOURNAL OF NATURAL MEDICINES　Vol. 67　No. 2　p. 271-275　2013/04　Research paper (scientific journal)

Creation of Readily Accessible and Orally Active Analogue of Cortistatin A

Naoyuki Kotoku, Yuji Sumii, Takeshi Hayashi, Satoru Tamura, Takashi Kawachi, Sho Shiomura, Masayoshi Arai, Motomasa Kobayashi

ACS MEDICINAL CHEMISTRY LETTERS　Vol. 3　No. 8　p. 673-677　2012/08　Research paper (scientific journal)

Neamphamide B, new cyclic depsipeptide, as an anti-dormant mycobacterial substance from a Japanese marine sponge of Neamphius sp.

Yoshi Yamano, Masayoshi Arai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 22　No. 14　p. 4877-4881　2012/07　Research paper (scientific journal)

Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.

Masayoshi Arai, Yoshi Yamano, Mayumi Fujita, Andi Setiawan, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 22　No. 4　p. 1818-1821　2012/02　Research paper (scientific journal)

P-30 Synthetic Studies and Biological Evaluation of Cortistatin A, an Anti-Angiogenic Steroidal Alkaloid from Marine Sponge, and Its Analogs(Poster Presentation)

Sumii Yuji, Kotoku Naoyuki, Hayashi Takeshi, Tamura Satoru, Kawachi Takashi, Morimoto Kaoru, Arai Masayoshi, Kobayashi Motomasa

Symposium on the Chemistry of Natural Products, symposium papers　No. 53　p. 571-576　2011/09/02

Concise synthesis and structure-activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge

Naoyuki Kotoku, Shinichi Fujioka, Chiaki Nakata, Masaki Yamada, Yuji Sumii, Takashi Kawachi, Masayoshi Arai, Motomasa Kobayashi

TETRAHEDRON　Vol. 67　No. 35　p. 6673-6678　2011/09　Research paper (scientific journal)

Action-Mechanism of Trichoderin A, an Anti-dormant Mycobacterial Aminolipopeptide from Marine Sponge-Derived Trichoderma sp.

Patamaporn Pruksakorn, Masayoshi Arai, Liu Liu, Prashini Moodley, William Robert Jacobs, Motomasa Kobayashi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 34　No. 8　p. 1287-1290　2011/08　Research paper (scientific journal)

DedA Protein Relates to Action-Mechanism of Halicyclamine A, a Marine Spongean Macrocyclic Alkaloid, as an Anti-dormant Mycobacterial Substance

Masayoshi Arai, Liu Liu, Takao Fujimoto, Andi Setiawan, Motomasa Kobayashi

MARINE DRUGS　Vol. 9　No. 6　p. 984-993　2011/06　Research paper (scientific journal)

Inhibitory Effect of Cyclic Trihydroxamate Siderophore, Desferrioxamine E, on the Biofilm Formation of Mycobacterium Species

Shunsuke Ishida, Masayoshi Arai, Hiroki Niikawa, Motomasa Kobayashi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 34　No. 6　p. 917-920　2011/06　Research paper (scientific journal)

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

Masayoshi Arai, Asami Hayashi, Mari Sobou, Shunsuke Ishida, Takashi Kawachi, Naoyuki Kotoku, Motomasa Kobayashi

JOURNAL OF NATURAL MEDICINES　Vol. 65　No. 1　p. 149-156　2011/01　Research paper (scientific journal)

Hypoxia-Selective Growth Inhibition of Cancer Cells by Furospinosulin-1, a Furanosesterterpene Isolated from an Indonesian Marine Sponge

Masayoshi Arai, Takashi Kawachi, Andi Setiawan, Motomasa Kobayashi

CHEMMEDCHEM　Vol. 5　No. 11　p. 1919-1926　2010/11　Research paper (scientific journal)

Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity

Naoyuki Kotoku, Xiu-Han Guo, Masayoshi Arai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 20　No. 14　p. 4152-4155　2010/07　Research paper (scientific journal)

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn, Masayoshi Arai, Naoyuki Kotoku, Catherine Vilcheze, Anthony D. Baughn, Prashini Moodley, William R. Jacobs, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 20　No. 12　p. 3658-3663　2010/06　Research paper (scientific journal)

Haliclonacyclamines, Tetracyclic Alkylpiperidine Alkaloids, as Anti-dormant Mycobacterial Substances from a Marine Sponge of Haliclona sp.

Masayoshi Arai, Shunsuke Ishida, Andi Settawan, Motomasa Kobayashi

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 57　No. 10　p. 1136-1138　2009/10　Research paper (scientific journal)

Pyripyropenes, Fungal Sesquiterpenes Conjugated with alpha-Pyrone and Pyridine Moieties, Exhibits Anti-angiogenic Activity against Human Umbilical Vein Endothelial Cells

Asami Hayashi, Masayoshi Arai, Mayumi Fujita, Motomasa Kobayashi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 32　No. 7　p. 1261-1265　2009/07　Research paper (scientific journal)

Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death

Hideaki Suna, Masayoshi Arai, Yoshie Tsubotani, Asami Hayashi, Andi Setiawan, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 17　No. 11　p. 3968-3972　2009/06　Research paper (scientific journal)

Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent

Masayoshi Arai, Mari Sobou, Catherine Vilcheze, Anthony Baughn, Hiroyuki Hashizume, Patamaporn Pruksakorn, Shunsuke Ishida, Makoto Matsumoto, William R. Jacobs, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 16　No. 14　p. 6732-6736　2008/07　Research paper (scientific journal)

Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids

Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Masayoshi Arai, Hideaki Suna, Katsushiro Miyamoto, Hiroshi Tsujibo, Kazutake Tsujikawa, Hiroshi Yamamoto, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 15　No. 21　p. 6758-6762　2007/11　Research paper (scientific journal)

Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived fungus Aspergillus candidus IF10

Hong Wei, Hirohiko Inada, Asarni Hayashi, Kenichi Higashimoto, Patamaporn Pruksakorn, Sayo Kamada, Masayoshi Arai, Shunsuke Ishida, Motomasa Kobayashi

JOURNAL OF ANTIBIOTICS　Vol. 60　No. 9　p. 586-590　2007/09　Research paper (scientific journal)

Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata

Shunji Aoki, Mami Sanagawa, Yasuo Watanabe, Andi Setiawan, Masayoshi Arai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 15　No. 14　p. 4818-4828　2007/07　Research paper (scientific journal)

Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171

Masato Iwatsuki, Ryuji Uchida, Yoichi Takakusagi, Atsuko Matsumoto, Cheng-Lin Jiang, Yoko Takahashi, Masayoshi Arai, Susumu Kobayashi, Makoto Matsumoto, Junji Inokoshi, Hiroshi Tomoda, Satoshi Omura

JOURNAL OF ANTIBIOTICS　Vol. 60　No. 6　p. 357-363　2007/06　Research paper (scientific journal)

Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Andi Setiawan, Masayoshi Arai, Motomasa Kobayashi

TETRAHEDRON LETTERS　Vol. 48　No. 26　p. 4485-4488　2007/06　Research paper (scientific journal)

Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli

Oren Zimhony, Catherine Vilcheze, Masayoshi Arai, John T. Welch, William R. Jacobs

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　Vol. 51　No. 2　p. 752-754　2007/02　Research paper (scientific journal)

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

Catherine Vilcheze, Feng Wang, Masayoshi Arai, Manzour Hernando Hazbon, Roberto Colangeli, Laurent Kremer, Torin R. Weisbrod, David Alland, James C. Sacchettini, William R. Jacobs

NATURE MEDICINE　Vol. 12　No. 9　p. 1027-1029　2006/09　Research paper (scientific journal)

Boromycin abrogates bleomycin-induced G2 checkpoint

M Arai, Y Koizumi, H Sato, T Kawabe, M Suganuma, H Kobayashi, H Tomada, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 57　No. 10　p. 662-668　2004/10　Research paper (scientific journal)

Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization.

Yukio Koizumi, Masayoshi Arai, Hiroshi Tomoda, Satoshi Omura

Biochimica et biophysica acta　Vol. 1693　No. 1　p. 47-55　2004/07/23　Research paper (scientific journal)

Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization

Y Koizumi, M Arai, H Tomoda, S Omura

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH　Vol. 1693　No. 1　p. 47-55　2004/07　Research paper (scientific journal)

Analysis of the mechanism of anti-mycotic activities by azoles potentiated by new erythromycin derivatives.

Omura S, Arai M, Sato K, Nagamitsu T, Nagai K, Sunazuka T, Tomoda H

Jpn. J. Antibiot.　Vol. 57　No. Suppl A　p. 96-100　2004/06　Research paper (scientific journal)

Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin alpha

M Arai, H Sato, H Kobayashi, M Suganuma, T Kawabe, H Tomoda, S Omura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 317　No. 3　p. 817-822　2004/05　Research paper (scientific journal)

New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 - II. Structure elucidation.

T Fukuda, M Arai, H Tomoda, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 57　No. 2　p. 117-124　2004/02　Research paper (scientific journal)

New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 - I. Taxonomy, fermentation, isolation and biological properties

T Fukuda, M Arai, Y Yamaguchi, R Masuma, H Tomoda, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 57　No. 2　p. 110-116　2004/02　Research paper (scientific journal)

Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization

Yukio Koizumi, Masayoshi Arai, Hiroshi Tomoda, Satoshi Omura

Journal of Antibiotics　Vol. 57　No. 7　p. 415-420　2004　Research paper (scientific journal)

Structure elucidation of new monordens produced by Humicola sp FO-2942

K Yamamoto, H Hatano, M Arai, K Shiomi, H Tomoda, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 56　No. 6　p. 533-538　2003/06　Research paper (scientific journal)

New monordens produced by amidepsine-producing fungus Humicola sp FO-2942

M Arai, K Yamamoto, Namatame, I, H Tomoda, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 56　No. 6　p. 526-532　2003/06　Research paper (scientific journal)

Purification of Shiga-like toxin 1 by pigeon egg white glycoproteins immobilized on Sepharose gels

H Tomoda, M Arai, N Koyama, H Matsui, S Omura, R Obata, YC Lee

ANALYTICAL BIOCHEMISTRY　Vol. 311　No. 1　p. 50-56　2002/12　Research paper (scientific journal)

Phoma sp. FOM-8108, a producer of gentisylquinones, isolated from sea sand

Yuichi Yamaguchi, Rokuro Masuma, Ryuji Uchida, Masayoshi Arai, Hiroshi Tomoda, Satoshi Omura

Mycoscience　Vol. 43　No. 2　p. 127-133　2002/04/25　Research paper (scientific journal)

Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076

M Arai, H Tomoda, T Okuda, HY Wang, N Tabata, R Masuma, Y Yamaguchi, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 55　No. 2　p. 172-180　2002/02　Research paper (scientific journal)

Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus

R Uchida, H Tomoda, M Arai, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 54　No. 11　p. 882-889　2001/11　Research paper (scientific journal)

Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp WK-6326 - II. Structure elucidation

M Arai, H Tomoda, N Tabata, N Ishiguro, S Kobayashi, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 54　No. 7　p. 562-566　2001/07　Research paper (scientific journal)

Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp WK-6326 - I. Taxonomy, fermentation, isolation and biological activities

M Arai, H Tomoda, A Matsumoto, Y Takahashi, BH Woodruff, N Ishiguro, S Kobayashi, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 54　No. 7　p. 554-561　2001/07　Research paper (scientific journal)

Effect of fungal metabolites cytochalasans on lipid droplet formation in mouse macrophages

Namatame, I, H Tomoda, M Arai, S Omura

JOURNAL OF ANTIBIOTICS　Vol. 53　No. 1　p. 19-25　2000/01　Research paper (scientific journal)

Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway

K Nomura, H Imai, T Koumura, M Arai, Y Nakagawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 41　p. 29294-29302　1999/10　Research paper (scientific journal)

Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages

N Chiba, H Imai, K Narashima, M Arai, G Oshima, M Kunimoto, Y Nakagawa

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 22　No. 10　p. 1047-1051　1999/10　Research paper (scientific journal)

PHGPxによるミトコンドリアを介するアポトーシスの抑制

幸村 知子, 今井 浩孝, 野村 和弘, 荒井 雅吉, 中川 靖一

生化学　Vol. 71　No. 8　p. 955-955　1999/08

ミトコンドリア型PHGPxによるアポトーシス抑制機構の解析

野村 和弘, 今井 浩孝, 幸村 知子, 荒井 雅吉, 中川 靖一

脂質生化学研究　Vol. 41　p. 246-249　1999/05

ミトコンドリア型PHGPxによるアポトーシス抑制機構の解析(1)

幸村 知子, 野村 和弘, 今井 浩孝, 荒井 雅吉, 中川 靖一

日本薬学会年会要旨集　Vol. 119年会　No. 3　p. 105-105　1999/03

ミトコンドリア型PHGPxによるアポトーシス抑制機構の解析(2)

野村 和弘, 今井 浩孝, 幸村 知子, 荒井 雅吉, 中川 靖一

日本薬学会年会要旨集　Vol. 119年会　No. 3　p. 105-105　1999/03

Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells

M Arai, H Imai, T Koumura, M Yoshida, K Emoto, M Umeda, N Chiba, Y Nakagawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 8　p. 4924-4933　1999/02　Research paper (scientific journal)

Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase

H Imai, K Narashima, M Arai, H Sakamoto, N Chiba, Y Nakagawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 273　No. 4　p. 1990-1997　1998/01　Research paper (scientific journal)

Preferential esterification of endogenously formed 5-hydroxyeicosatetraenoic acid to phospholipids in activated polymorphonuclear leukocytes

M Arai, H Imai, A Metori, Y Nakagawa

EUROPEAN JOURNAL OF BIOCHEMISTRY　Vol. 244　No. 2　p. 513-519　1997/03　Research paper (scientific journal)

Import into mitochondria of phospholipid hydroperoxide glutathione peroxidase requires a leader sequence

M Arai, H Imai, D Sumi, T Imanaka, T Takano, N Chiba, Y Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 227　No. 2　p. 433-439　1996/10　Research paper (scientific journal)

Overexpression of phospholipid hydroperoxide glutathione peroxidase suppressed cell death due to oxidative damage in rat basophile leukemia cells (RBL-2H3)

H Imai, D Sumi, H Sakamoto, A Hanamoto, M Arai, N Chiba, Y Nakagawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 222　No. 2　p. 432-438　1996/05　Research paper (scientific journal)

Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression.

Imai H, Sumi D, Hanamoto A, Arai M, Sugiyama A, Chiba N, Kuchino Y, Nakagawa Y

J. Biochem.　Vol. 118(5), 1061-1067.　p. 1061-1067　1995/07　Research paper (scientific journal)