顔写真

PHOTO

Ichiyama Kenji
市山　健司
Ichiyama Kenji
市山　健司
Immunology Frontier Research Center，Specially Appointed Associate Professor (Full Time)

Research History 7

  1. 2021/01 - Present
    Osaka University

  2. 2016/01 - 2020/12
    Osaka University

  3. 2014/12 - 2015/12
    Children’s National Medical Center　Research Associate

  4. 2014/06 - 2014/11
    UT MD Anderson Cancer Center　Postdoctoral Fellow

  5. 2012/06 - 2014/05
    UT MD Anderson Cancer Center

  6. 2011/01 - 2012/05
    UT MD Anderson Cancer Center

  7. 2009/04 - 2010/12
    慶応義塾大学医学部　微生物学・免疫学研究室　特別研究員PD

Education 4

  1. 九州大学　大学院医学系学府　病態医学専攻 特別研究員DC2

    2008/04 - 2009/03

  2. Kyushu University

    2006/04 - 2008/03

  3. Okayama University　Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

    2004/04 - 2006/03

  4. Okayama University　Faculty of Pharmaceutical Sciences　Department of Pharmacy

    2000/04 - 2004/03

Professional Memberships 4

  1. 日本薬学会

  2. 日本生化学会

  3. 日本分子生物学会

  4. 日本免疫学会

Research Areas 2

  1. Life sciences / Molecular biology /

  2. Life sciences / Immunology /

Awards 5

  1. 大阪大学賞

    大阪大学　2022/11

  2. 日本免疫学会研究奨励賞

    日本免疫学会　2017/12

  3. ベストプレゼンテーション賞

    日本免疫学会　2016/12

  4. 優秀プレゼンテーション賞

    日本生化学会　2009/10

  5. 優秀口演賞

    GCOE理医連携リトリート　2008/08

Papers 27

  1. Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity.

    Kenji Ichiyama, Jia Long, Yusuke Kobayashi, Yuji Horita, Takeshi Kinoshita, Yamami Nakamura, Chizuko Kominami, Katia Georgopoulos, Shimon Sakaguchi

    Immunity　Vol. 57　No. 9　p. 2043-2060　2024/09/10　Research paper (scientific journal)

  2. Regulatory T Cells and Human Disease.

    Shimon Sakaguchi, Norihisa Mikami, James B Wing, Atsushi Tanaka, Kenji Ichiyama, Naganari Ohkura

    Annual review of immunology　Vol. 38　p. 541-566　2020/02/04　Research paper (scientific journal)

  3. The role of miR-183 cluster in immunity.

    Kenji Ichiyama, Chen Dong

    Cancer letters　Vol. 443　p. 108-114　2019/02/28

  4. The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.

    Kenji Ichiyama, Alicia Gonzalez-Martin, Byung-Seok Kim, Hyun Yong Jin, Wei Jin, Wei Xu, Mohsen Sabouri-Ghomi, Shunbin Xu, Pan Zheng, Changchun Xiao, Chen Dong

    Immunity　Vol. 44　No. 6　p. 1284-98　2016/06/21

  5. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.

    Kenji Ichiyama, Tingting Chen, Xiaohu Wang, Xiaowei Yan, Byung-Seok Kim, Shinya Tanaka, Delphine Ndiaye-Lobry, Yuhua Deng, Yanli Zou, Pan Zheng, Qiang Tian, Iannis Aifantis, Lai Wei, Chen Dong

    Immunity　Vol. 42　No. 4　p. 613-26　2015/04/21　Research paper (scientific journal)

  6. Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.

    Kenji Ichiyama, Takashi Sekiya, Naoko Inoue, Taiga Tamiya, Ikko Kashiwagi, Akihiro Kimura, Rimpei Morita, Go Muto, Takashi Shichita, Reiko Takahashi, Akihiko Yoshimura

    Immunity　Vol. 34　No. 5　p. 741-54　2011/05/27

  7. Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity.

    Kenji Ichiyama, Masayuki Hashimoto, Takashi Sekiya, Ryusuke Nakagawa, Yu Wakabayashi, Yuki Sugiyama, Kyoko Komai, Ingrid Saba, Tarik Möröy, Akihiko Yoshimura

    International immunology　Vol. 21　No. 7　p. 881-9　2009/07

  8. Promotion of IL-4- and IL-5-dependent differentiation of anti-mu-primed B cells by ascorbic acid 2-glucoside.

    Kenji Ichiyama, Hitoshi Mitsuzumi, Ming Zhong, Akihiro Tai, Akihiro Tsuchioka, Saeko Kawai, Itaru Yamamoto, Eiichi Gohda

    Immunology letters　Vol. 122　No. 2　p. 219-26　2009/02/21

  9. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.

    Kenji Ichiyama, Hideyuki Yoshida, Yu Wakabayashi, Takatoshi Chinen, Kazuko Saeki, Mako Nakaya, Giichi Takaesu, Shohei Hori, Akihiko Yoshimura, Takashi Kobayashi

    The Journal of biological chemistry　Vol. 283　No. 25　p. 17003-8　2008/06/20　Research paper (scientific journal)

  10. Augmentation of antigen-specific antibody production and IL-10 generation with a fraction from Rooibos (Aspalathus linearis) tea.

    Kenji Ichiyama, Akihiro Tai, Itaru Yamamoto

    Bioscience, biotechnology, and biochemistry　Vol. 71　No. 2　p. 598-602　2007/02

  11. Correction: PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

    Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu

    Cell reports　Vol. 34　No. 12　2021/03/23　Research paper (scientific journal)

    Publisher: CELL PRESS

  12. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3.

    Kentaro Tanaka, Gustavo J Martinez, Xiaowei Yan, Weiwen Long, Kenji Ichiyama, Xinxin Chi, Byung-Seok Kim, Joseph M Reynolds, Yeonseok Chung, Shinya Tanaka, Lan Liao, Yoichi Nakanishi, Akihiko Yoshimura, Pan Zheng, Xiaohu Wang, Qiang Tian, Jianming Xu, Bert W O'Malley, Chen Dong

    Cell reports　Vol. 23　No. 8　p. 2318-2329　2018/05/22

  13. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity.

    Byung-Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi-Bing Zhang, Nipun A Mistry, Kentaro Tanaka, Young-Hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, Chen Dong

    Cell reports　Vol. 21　No. 1　p. 195-207　2017/10/03

  14. Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation.

    Xindong Liu, Huiping Lu, Tingting Chen, Kalyan C Nallaparaju, Xiaowei Yan, Shinya Tanaka, Kenji Ichiyama, Xia Zhang, Li Zhang, Xiaofeng Wen, Qiang Tian, Xiu-Wu Bian, Wei Jin, Lai Wei, Chen Dong

    Cell reports　Vol. 14　No. 7　p. 1735-1747　2016/02/23

  15. Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.

    Taiga Tamiya, Kenji Ichiyama, Hitoshi Kotani, Tomohiro Fukaya, Takashi Sekiya, Takashi Shichita, Kiri Honma, Katsuyuki Yui, Toshifumi Matsuyama, Takako Nakao, Satoru Fukuyama, Hiromasa Inoue, Masatoshi Nomura, Akihiko Yoshimura

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 191　No. 5　p. 2360-71　2013/09/01

  16. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

    Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu

    Cell reports　Vol. 1　No. 4　p. 360-73　2012/04/19

  17. 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A.

    Sneha Joshi, Luiz-Carlos Pantalena, Xikui K Liu, Sarah L Gaffen, Hong Liu, Christine Rohowsky-Kochan, Kenji Ichiyama, Akihiko Yoshimura, Lawrence Steinman, Sylvia Christakos, Sawsan Youssef

    Molecular and cellular biology　Vol. 31　No. 17　p. 3653-69　2011/09

  18. SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.

    Masayuki Hashimoto, Kiyokazu Hiwatashi, Kenji Ichiyama, Rimpei Morita, Takashi Sekiya, Akihiro Kimura, Yuki Sugiyama, Toshikatsu Sibata, Kazumichi Kuroda, Reiko Takahashi, Akihiko Yoshimura

    International immunology　Vol. 23　No. 3　p. 165-76　2011/03

  19. Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.

    Tomohito Takimoto, Yu Wakabayashi, Takashi Sekiya, Naoko Inoue, Rimpei Morita, Kenji Ichiyama, Reiko Takahashi, Mayako Asakawa, Go Muto, Tomoaki Mori, Eiichi Hasegawa, Shizuya Saika, Toshiro Hara, Masatoshi Nomura, Akihiko Yoshimura

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 185　No. 2　p. 842-55　2010/07/15

  20. STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.

    Hiromi Takaki, Kenji Ichiyama, Keiko Koga, Takatoshi Chinen, Giichi Takaesu, Yuki Sugiyama, Shigeaki Kato, Akihiko Yoshimura, Takashi Kobayashi

    The Journal of biological chemistry　Vol. 283　No. 22　p. 14955-62　2008/05/30　Research paper (scientific journal)

  21. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.

    Kentaro Tanaka, Kenji Ichiyama, Masayuki Hashimoto, Hideyuki Yoshida, Tomohito Takimoto, Giichi Takaesu, Takehiro Torisu, Toshikatsu Hanada, Hideo Yasukawa, Satoru Fukuyama, Hiromasa Inoue, Yoichi Nakanishi, Takashi Kobayashi, Akihiko Yoshimura

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 180　No. 6　p. 3746-56　2008/03/15　Research paper (scientific journal)

  22. Inhibition of free radical-induced erythrocyte hemolysis by 2-O-substituted ascorbic acid derivatives

    Takebayashi Jun, Kaji Hiroaki, Ichiyama Kenji, Makino Kazutaka, Gohda Eiichi, Yamamoto Itaru, Tai Akihiro

    VITAMINS　Vol. 82　No. 3　p. 187-189　2008

    Publisher: THE VITAMIN SOCIETY OF JAPAN

  23. Inhibition of free radical-induced erythrocyte hemolysis by 2-O-substituted ascorbic acid derivatives.

    Jun Takebayashi, Hiroaki Kaji, Kenji Ichiyama, Kazutaka Makino, Eiichi Gohda, Itaru Yamamoto, Akihiro Tai

    Free radical biology & medicine　Vol. 43　No. 8　p. 1156-64　2007/10/15

  24. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells.

    Yumiko Matsumura, Takashi Kobayashi, Kenji Ichiyama, Ryoko Yoshida, Masayuki Hashimoto, Tomohito Takimoto, Kentaro Tanaka, Takatoshi Chinen, Takashi Shichita, Tony Wyss-Coray, Katsuaki Sato, Akihiko Yoshimura

    Journal of immunology (Baltimore, Md. : 1950)　Vol. 179　No. 4　p. 2170-9　2007/08/15　Research paper (scientific journal)

  25. Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.

    Moriyasu Yamauchi, Masayuki Hashimoto, Kenji Ichiyama, Ryoko Yoshida, Toshikatsu Hanada, Tatsushi Muta, Shizuo Komune, Takashi Kobayashi, Akihiko Yoshimura

    International immunology　Vol. 19　No. 8　p. 935-42　2007/08

  26. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.

    Koji Taniguchi, Ri-Ichiro Kohno, Toranoshin Ayada, Reiko Kato, Kenji Ichiyama, Tohru Morisada, Yuichi Oike, Yoshikazu Yonemitsu, Yoshihiko Maehara, Akihiko Yoshimura

    Molecular and cellular biology　Vol. 27　No. 12　p. 4541-50　2007/06　Research paper (scientific journal)

  27. Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.

    Koji Taniguchi, Toranoshin Ayada, Kenji Ichiyama, Ri-Ichiro Kohno, Yoshikazu Yonemitsu, Yasuhiro Minami, Akira Kikuchi, Yoshihiko Maehara, Akihiko Yoshimura

    Biochemical and biophysical research communications　Vol. 352　No. 4　p. 896-902　2007/01/26　Research paper (scientific journal)

Misc. 11

  1. The microRNA-183 cluster promotes Th17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression

    Vol. 67　No. 5　p. 513-518　2017/05

    Publisher: 科学評論社

  2. 最新免疫学×周産期医学 基礎医学-免疫学の最初の一歩 制御性T細胞

    市山健司, 坂口志文

    周産期医学　Vol. 47　No. 12　2017

  3. miR-183クラスターは転写因子Foxo1の発現を負に制御することによりTh17細胞の病原性を促進する

    市山健司, Chen Dong

    ライフサイエンス新着論文レビュー　2016　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  4. Role of TGF-beta-Smad2/3 signaling in helper T cell function and differentiation

    Akihiko Yoshimura, Kenji Ichiyama, Ikko Kashiwagi

    CYTOKINE　Vol. 56　No. 1　p. 20-20　2011/10　Research paper, summary (international conference)

  5. TGF-betaによるSmadに非依存性のTh17細胞の分化誘導は転写因子Eomesの抑制を介する

    市山健司, 吉村昭彦

    ライフサイエンス新着論文レビュー　2011　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  6. Th17細胞分化の誘導と抑制 Th17細胞分化を制御する転写因子

    市山健司, 吉村昭彦

    月刊臨床免疫・アレルギー科　Vol. 54　No. 4　2010

  7. 細胞の個性に応じて機能するTGF-βファミリー TGF-βによるヘルパーT細胞の分化制御

    市山健司, 吉村昭彦

    実験医学　Vol. 28　No. 6　2010

  8. 注目されるサイトカイン TGF-βと免疫応答

    市山健司

    臨床検査　Vol. 54　No. 6　2010

  9. Regulation of Th17 and iTreg by cytokines

    Cell technology.　Vol. 27　No. 2　p. 137-143　2008/02

    Publisher: 秀潤社

  10. 2-0-置換型アスコルビン酸誘導体によるフリーラジカル誘導性赤血球溶血反応の抑制

    竹林純, 加地弘明, 市山健司, 牧野和隆, 合田榮一, 山本格, 田井章博

    ビタミン　Vol. 82　No. 3　2008

  11. SOCS1/SOCS3によるTh細胞の分化制御-Th3とTh17を中心に-

    田中謙太郎, 市山健司, 橋本雅之, 小林隆志, 吉村昭彦

    月刊臨床免疫・アレルギー科　Vol. 48　No. 4　2007

Presentations 19

  1. エピジェネティクス機構によるTh17および自己免疫性脳脊髄炎の制御

    第4回病因研究会別府シンポジウム　2017/03/10

  2. 多様な生命現象を担うTGF-βのバイオロジー

    第 32 回日本分子生物学会年会　2009/12/11

  3. Foxp3 依存的遺伝子発現制御における Foxp3-Ikzf1 相互作用の役割:相互作用阻害に よる自己免疫と腫瘍免疫の誘導

    市山健司

    第33回Kyoto T Cell Conference

  4. Foxp3 は転写因子 Ikzf1 との相互作用を介して制御性 T 細胞の機能安定性を制御する

    市山健司

    日本薬学会 第144年会

  5. Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: disruption of the association causes autoimmunity

    Kenji Ichiyama

    Keystone Symposia on Molecular and Cellular Biology [Systemic Autoimmune and Autoinflammatory Diseases (B2)]　2024/02/11

  6. MBD3 Facilitates Thymic Treg Precursor Development and Treg Lineage Commitment by Altering CD25 Expression

    Long Jia, Kenji Ichiyama

    2023/01/17

  7. Exon 5 of Ikzf1 is required for Foxp3-dependent gene suppression to maintain the homeostasis of regulatory T cells

    2022/12/08

  8. SRC2 and SRC3 cooperatively regulate Th17 cell development.

    Kenji Ichiyama

    2021/12/09

  9. Epigenetic regulation of pathogenic T helper 17 cell differentiation by steroid receptor coactivators

    第48回日本免疫学会総会・学術集会　2019/12/11

  10. ステロイド受容体活性化補助因子SRC2およびSRC3はエピジェネティックな活性化制御を介してTh17分化を促進する

    日本薬学会 第139年会　2019/03/23

  11. Identification and functional elucidation of novel regulators in the development of IL-17-producing helper T cells

    第46回日本免疫学会総会・学術集会　2017/12/12

  12. The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression

    第43回内藤カンファレンス「Noncoding RNA: Biology, Chemistry & Diseases」　2017/06/27

  13. The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression

    第45回日本免疫学会総会・学術集会　2016/12/07

  14. microRNA-183-96-182 cluster positively regulates pathogenic function of Th17 cells

    第26回Kyoto T Cell Conference (KTCC)　2016/05/20

  15. Gfi1はRORgammatの活性を阻害することでTh17分化を負に制御する

    第39回日本免疫学会総会・学術集会　2009/12/02

  16. 新規IL-17A発現制御因子の探索

    第82回日本生化学会大会　2009/10/21

  17. The reduction of Foxp3 expression by IL-6 mediates the production of IL-4.

    Keystone Symposia on Molecular and Cellular Biology [Regulatory T Cells]　2009/03/01

  18. Foxp3はRORgammatに作用してRORgammat誘導性のIL-17A転写促進を抑制する

    第38回日本免疫学会総会・学術集会　2008/12/01

  19. Regulation of Th17 and iTreg by Cytokines.

    第9回文部科学省特定領域研究「がん」5領域 若手研究者ワークショップ　2008/09/03

Industrial Property Rights 1

  1. 腫瘍の予防および/または治療剤

    市山健司, 坂口志文, 堀田祐司, 木下武士

    出願日:2023

Social Activities 1

  • The 28th IFReC Colloquium

    2016/12 -

Media Coverage 4

  1. 免疫抑制細胞の重要たんぱく質、大阪大発見 治療応用も

    2024/08

  2. Fine-Tuning Th17 Cells: To Be or Not To Be Pathogenic?

    2016/06/21

  3. Tet2: Breaking Down Barriers to T Cell Cytokine Expression

    2015/04/21

  4. 自己免疫疾患の発症を抑える新たな免疫調節機構発見

    2011/06

Academic Activities 2

  1. Review Editor for Immunological Tolerance and Regulation

    Frontier in Immunology

    2022/07/11 - Present

  2. 第48回日本免疫学会学術集会

    2019/12/11 -