顔写真

PHOTO

Sasai Miwa
笹井　美和
Sasai Miwa
笹井　美和
Institutional repository
Research Institute for Microbial Diseases，Associate Professor

keyword Parasitology，Innate Immunity

Institutional repository

Research History 5

  1. 2017/08 - Present
    Osaka University　Research Institute for Microbial Diseases

  2. 2012/04 - 2017/07
    Osaka University　Research Institute for Microbial Diseases

  3. 2007/04 - 2012/03
    Yale University　Immunobiology

  4. 2009/04 - 2011/03
    日本学術振興会　海外特別研究員

  5. 2005/04 - 2007/03
    日本学術振興会　特別研究員

Research Areas 1

  1. Life sciences / Immunology /

Awards 5

  1. 大阪大学賞

    笹井 美和　大阪大学　2018/11

  2. 文部科学大臣表彰・若手科学者賞

    笹井 美和　文部科学省　2018/04

  3. 若手科学者賞

    笹井 美和　文部科学省　2018/04

  4. 2017 JSI Young Investigator Award

    Miwa Sasai　Japanese Society for Immunology(JSI)　2017/12

  5. JSI Young Investigator Award

    Sasai Miwa　Japanese Society for Immunology (JSI)　2017/12

Papers 74

  1. Phosphatidic acid production on the vacuole harboring Legionella pneumophila is a signal for recognition of interferon-induced GTPases.

    Hiromu Oide, Tomoko Kubori, Hiroki Nagai, Takashi Nozawa, Ichiro Nakagawa, Miwa Sasai, Masahiro Yamamoto, Kohei Arasaki

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 122　No. 32　2025/08/12　Research paper (scientific journal)

  2. Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production.

    Yuki Nakayama, Fumiaki Ihara, Daisuke Okuzaki, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

    Parasitology international　Vol. 105　p. 102995-102995　2025/04/01　Research paper (scientific journal)

  3. Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology.

    Yuki Nakayama, Miwa Sasai, Ayumi Kuratani, Masaaki Okamoto, Daisuke Okuzaki, Kentaro Yamamoto, Chikako Ono, Masaya Yamaguchi, Shigetada Kawabata, Noriko Shinjyo, Yasutaka Okabe, Yoshiharu Matsuura, Manabu Ato, Masahiro Yamamoto

    iScience　Vol. 28　No. 3　p. 111975-111975　2025/03/21　Research paper (scientific journal)

  4. Discrepancies in the Diagnosis of Congenital Toxoplasma gondii Infection Between B1 Gene Semi-Nested Polymerase Chain Reaction and Serological Analyses.

    Akiko Uchida, Kenji Tanimura, Keisuke Shirai, Mariko Ashina, Kazumichi Fujioka, Ichiro Morioka, Miwa Sasai, Masahiro Yamamoto, Hideto Yamada

    Microorganisms　Vol. 13　No. 3　2025/03/05　Research paper (scientific journal)

  5. IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.

    Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 48　2024/11/26　Research paper (scientific journal)

  6. Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity.

    Ayumi Kuratani, Masaaki Okamoto, Kazuki Kishida, Daisuke Okuzaki, Miwa Sasai, Shimon Sakaguchi, Hisashi Arase, Masahiro Yamamoto

    Science (New York, N.Y.)　Vol. 386　No. 6724　2024/11/22　Research paper (scientific journal)

  7. CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma.

    Yuta Tachibana, Miwa Sasai, Masahiro Yamamoto

    mBio　Vol. 15　No. 9　2024/09/11　Research paper (scientific journal)

  8. Tff1-expressing Tregs in lung prevent exacerbation of Bleomycin-induced pulmonary fibrosis.

    Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto

    Frontiers in immunology　Vol. 15　p. 1440918-1440918　2024/09/01　Research paper (scientific journal)

  9. Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis.

    Tokuju Okano, Hiroshi Ashida, Noriko Komatsu, Masayuki Tsukasaki, Tamako Iida, Marie Iwasawa, Yuto Takahashi, Yasuo Takeuchi, Takanori Iwata, Miwa Sasai, Masahiro Yamamoto, Hiroshi Takayanagi, Toshihiko Suzuki

    International journal of oral science　Vol. 16　No. 1　p. 54-54　2024/08/15　Research paper (scientific journal)

  10. Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.

    Chisato Sakuma, Sayaka Shizukuishi, Michinaga Ogawa, Yuko Honjo, Haruko Takeyama, Jun-Lin Guan, Jeffery Weiser, Miwa Sasai, Masahiro Yamamoto, Makoto Ohnishi, Yukihiro Akeda

    Cell reports　Vol. 43　No. 5　p. 114131-114131　2024/05/28　Research paper (scientific journal)

  11. Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages.

    Fumiaki Ihara, Hisako Kyan, Yasuhiro Takashima, Fumiko Ono, Kei Hayashi, Tomohide Matsuo, Makoto Igarashi, Yoshifumi Nishikawa, Kenji Hikosaka, Hirokazu Sakamoto, Shota Nakamura, Daisuke Motooka, Kiyoshi Yamauchi, Madoka Ichikawa-Seki, Shinya Fukumoto, Motoki Sasaki, Hiromi Ikadai, Kodai Kusakisako, Yuma Ohari, Ayako Yoshida, Miwa Sasai, Michael E Grigg, Masahiro Yamamoto

    Nature communications　Vol. 15　No. 1　p. 4278-4278　2024/05/22　Research paper (scientific journal)

  12. Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

    Hiromichi Okuma, Yumiko Saijo-Hamano, Hiroshi Yamada, Aalaa Alrahman Sherif, Emi Hashizaki, Naoki Sakai, Takaaki Kato, Tsuyoshi Imasaki, Satoshi Kikkawa, Eriko Nitta, Miwa Sasai, Tadashi Abe, Fuminori Sugihara, Yoshimasa Maniwa, Hidetaka Kosako, Kohji Takei, Daron M Standley, Masahiro Yamamoto, Ryo Nitta

    Genes to cells : devoted to molecular & cellular mechanisms　Vol. 29　No. 1　p. 17-38　2024/01/01　Research paper (scientific journal)

  13. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19.

    Rae Maeda, Natsumi Seki, Yoshifumi Uwamino, Masatoshi Wakui, Yu Nakagama, Yasutoshi Kido, Miwa Sasai, Shu Taira, Naoya Toriu, Masahiro Yamamoto, Yoshiharu Matsuura, Jun Uchiyama, Genki Yamaguchi, Makoto Hirakawa, Yun-Gi Kim, Masayo Mishima, Motoko Yanagita, Makoto Suematsu, Yuki Sugiura

    Nature communications　Vol. 14　No. 1　p. 8469-8469　2023/12/20　Research paper (scientific journal)

  14. A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.

    Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B Wing, Shimon Sakaguchi, Masahiro Yamamoto

    Cell reports　Vol. 42　No. 7　p. 112813-112813　2023/07/25　Research paper (scientific journal)

  15. Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis.

    Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Anongwee Leewananthawet, Miwa Sasai, Masahiro Yamamoto, Hiroshi Ashida, Toshihiko Suzuki

    European journal of immunology　Vol. 53　No. 11　2023/07/20　Research paper (scientific journal)

  16. Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens.

    Yuta Tachibana, Emi Hashizaki, Miwa Sasai, Masahiro Yamamoto

    Cell reports　Vol. 42　No. 6　p. 112592-112592　2023/06/01　Research paper (scientific journal)

  17. TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.

    Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

    JCI insight　Vol. 8　No. 4　2023/02/22　Research paper (scientific journal)

  18. Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

    Emi Hashizaki, Miwa Sasai, Daisuke Okuzaki, Tsubasa Nishi, Takashi Kobayashi, Shiroh Iwanaga, Masahiro Yamamoto

    mBio　Vol. 14　No. 1　2023/01/30　Research paper (scientific journal)

  19. Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant

    Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Miwa Sasai, Chin Yang Chang, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Masahiro Yamamoto, Hironori Nakagami

    Scientific Reports　Vol. 12　No. 1　p. 20923-20923　2022/12/03　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  20. Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

    Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

    Nature cell biology　Vol. 24　No. 11　p. 1677-1679　2022/11/01　Research paper (scientific journal)

  21. Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation.

    Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A Tai, Hiroki Hayashi, Jiao Sun, Shiho Torii, Chikako Ono, Yoshiharu Matsuura, Ryoko Ide, Junichi Mineno, Miwa Sasai, Masahiro Yamamoto, Hironori Nakagami, Kunihiko Yamashita

    Immunological medicine　Vol. 45　No. 4　p. 1-14　2022/08/24　Research paper (scientific journal)

  22. Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms.

    Miwa Sasai, Masahiro Yamamoto

    Parasitology international　Vol. 89　p. 102593-102593　2022/08/01　Research paper (scientific journal)

  23. A prospective cohort study of newborns born to mothers with serum Toxoplasma gondii immunoglobulin M positivity during pregnancy.

    Midori Hijikata, Ichiro Morioka, Aya Okahashi, Nobuhiko Nagano, Kaori Kawakami, Atsushi Komatsu, Kei Kawana, Shohei Ohyama, Kazumichi Fujioka, Kenji Tanimura, Masashi Deguchi, Miwa Sasai, Masahiro Yamamoto, Hideto Yamada

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　Vol. 28　No. 4　p. 486-491　2022/04/01　Research paper (scientific journal)

  24. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

    Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe, Shintaro Sato, Masahiro Wakita, Shintaro Okumura, Sosuke Nakano, Tatsuyuki Matsudaira, Tomonori Matsumoto, Shimpei Kawamoto, Masahiro Yamamoto, Tokiko Watanabe, Yoshiharu Matsuura, Kazuo Takayama, Takeshi Kobayashi, Toru Okamoto, Eiji Hara

    Nature Aging　Vol. 2　No. 2　p. 115-124　2022/02/01　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  25. Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.

    Yumiko Saijo-Hamano, Aalaa Alrahman Sherif, Ariel Pradipta, Miwa Sasai, Naoki Sakai, Yoshiaki Sakihama, Masahiro Yamamoto, Daron M Standley, Ryo Nitta

    Life science alliance　Vol. 5　No. 1　2022/01/01　Research paper (scientific journal)

  26. Plasmodium UIS3 avoids host cell-autonomous exclusion that requires GABARAPs but not LC3 and autophagy

    Ariel Pradipta, Hironori Bando, Ji Su Ma, Shun Tanaka, Miwa Sasai, Masahiro Yamamoto

    Parasitology International　Vol. 83　2021/08/01　Research paper (scientific journal)

  27. Cell-Autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization

    Ariel Pradipta, Miwa Sasai, Kou Motani, Ji Su Ma, Youngae Lee, Hidetaka Kosako, Masahiro Yamamoto

    Life Science Alliance　Vol. 4　No. 7　2021/07/01　Research paper (scientific journal)

  28. An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

    Yafei Liu, Wai Tuck Soh, Jun ichi Kishikawa, Mika Hirose, Emi E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Takayuki Kato, Masato Okada, Daron M. Standley, Tatsuo Shioda, Hisashi Arase

    Cell　Vol. 184　No. 13　p. 3452-3.47E+21　2021/06/24　Research paper (scientific journal)

  29. Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells

    Miwa Sasai, Ji Su Ma, Masaaki Okamoto, Kohei Nishino, Hikaru Nagaoka, Eizo Takashima, Ariel Pradipta, Youngae Lee, Hidetaka Kosako, Pann Ghill Suh, Masahiro Yamamoto

    Journal of Experimental Medicine　Vol. 218　No. 7　2021/05/10　Research paper (scientific journal)

  30. Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

    Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A Tai, Hiroki Hayashi, Jiao Sun, Shiho Torii, Chikako Ono, Yoshiharu Matsuura, Ryoko Ide, Junichi Mineno, Miwa Sasai, Masahiro Yamamoto, Hironori Nakagami, Kunihiko Yamashita

    2021/01/14

    Publisher: Cold Spring Harbor Laboratory

  31. ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

    Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo

    Autophagy　p. 1-20　2020/12/15　Research paper (scientific journal)

    Publisher: Informa UK Limited

  32. LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

    Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

    Nature Cell Biology　Vol. 22　No. 10　p. 1252-1263　2020/10/01　Research paper (scientific journal)

  33. Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock

    Naoya Sakaguchi, Miwa Sasai, Hironori Bando, Youngae Lee, Ariel Pradipta, Ji Su Ma, Masahiro Yamamoto

    Frontiers in Immunology　Vol. 11　2020/09/15　Research paper (scientific journal)

  34. T cell-derived interferon-γ is required for host defense to Toxoplasma gondii

    Saishi Nishiyama, Ariel Pradipta, Ji Su Ma, Miwa Sasai, Masahiro Yamamoto

    Parasitology International　Vol. 75　2020/04/01　Research paper (scientific journal)

  35. Decision by injection without infection

    Miwa Sasai, Masahiro Yamamoto

    Journal of Experimental Medicine　Vol. 217　No. 3　2020/03/01　Research paper (scientific journal)

  36. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense

    Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M. Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto

    Life Science Alliance　Vol. 3　No. 1　2020　Research paper (scientific journal)

  37. Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection

    Miwa Sasai, Masahiro Yamamoto

    Experimental and Molecular Medicine　Vol. 51　No. 12　2019/12/01

  38. CXCR4 regulates Plasmodium development in mouse and human hepatocytes

    Hironori Bando, Ariel Pradipta, Shiroh Iwanaga, Toru Okamoto, Daisuke Okuzaki, Shun Tanaka, Joel Vega-Rodríguez, Youngae Lee, Ji Su Ma, Naoya Sakaguchi, Akira Soga, Shinya Fukumoto, Miwa Sasai, Yoshiharu Matsuura, Masao Yuda, Marcelo Jacobs-Lorena, Masahiro Yamamoto

    Journal of Experimental Medicine　Vol. 216　No. 8　p. 1733-1748　2019/08/01　Research paper (scientific journal)

  39. Toxoplasma effector GRA15-dependent suppression of IFN-γ-induced antiparasitic response in human neurons

    Hironori Bando, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ryoma Sakamoto, Shun Tanaka, Ji Su Ma, Miwa Sasai, Masahiro Yamamoto

    Frontiers in Cellular and Infection Microbiology　Vol. 9　No. MAY　2019　Research paper (scientific journal)

  40. GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

    Jin Kyung Kim, Yi Sak Kim, Hye Mi Lee, Hyo Sun Jin, Chiranjivi Neupane, Sup Kim, Sang Hee Lee, Jung Joon Min, Miwa Sasai, Jae Ho Jeong, Seong Kyu Choe, Jin Man Kim, Masahiro Yamamoto, Hyon E. Choy, Jin Bong Park, Eun Kyeong Jo

    Nature Communications　Vol. 9　No. 1　2018/12/01　Research paper (scientific journal)

  41. Toxoplasma effector TgIST targets host IDO1 to antagonize the IFN-γ-induced anti-parasitic response in human cells

    Hironori Bando, Naoya Sakaguchi, Youngae Lee, Ariel Pradipta, Ji Su Ma, Shun Tanaka, De Hua Lai, Jianfa Liu, Zhao Rong Lun, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

    Frontiers in Immunology　Vol. 9　No. SEP　2018/09/19　Research paper (scientific journal)

  42. Inducible nitric oxide synthase is a key host factor for Toxoplasma GRA15-dependent disruption of the gamma interferon-induced antiparasitic human response

    Hironori Bando, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ji Su Ma, Shun Tanaka, Yihong Cai, Jianfa Liu, Jilong Shen, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

    mBio　Vol. 9　No. 5　p. 01738-01756　2018/09　Research paper (scientific journal)

  43. Host immune responses to Toxoplasma gondii

    Miwa Sasai, Ariel Pradipta, Masahiro Yamamoto

    International Immunology　Vol. 30　No. 3　p. 113-119　2018/03/01　Research paper (scientific journal)

  44. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa

    Junki Hirano, Toru Okamoto, Yukari Sugiyama, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Takasuke Fukuhara, Miwa Sasai, Takahiro Tougan, Yasue Matsunaga, Kazuo Yamashita, Yusuke Sakai, Masahiro Yamamoto, Toshihiro Horii, Daron M. Standley, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 50　p. E10782-E10791　2017/12/12　Research paper (scientific journal)

  45. Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense

    Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M. Standley, Tamotsu Yoshimori, Masahiro Yamamoto

    Nature Immunology　Vol. 18　No. 8　p. 899-910　2017/07/19　Research paper (scientific journal)

  46. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

    Si Ming Man, Rajendra Karki, Miwa Sasai, David E. Place, Sannula Kesavardhana, Jamshid Temirov, Sharon Frase, Qifan Zhu, R. K.Subbarao Malireddi, Teneema Kuriakose, Jennifer L. Peters, Geoffrey Neale, Scott A. Brown, Masahiro Yamamoto, Thirumala Devi Kanneganti

    Cell　Vol. 167　No. 2　p. 382-396.e17　2016/10/06　Research paper (scientific journal)

  47. The P2X4 receptor is required for neuroprotection via ischemic preconditioning

    Tomohiko Ozaki, Rieko Muramatsu, Miwa Sasai, Masahiro Yamamoto, Yoshiaki Kubota, Toshiyuki Fujinaka, Toshiki Yoshimine, Toshihide Yamashita

    Scientific Reports　Vol. 6　2016/05/13　Research paper (scientific journal)

  48. P62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto

    Cell Reports　Vol. 13　No. 2　p. 223-233　2015/10/13　Research paper (scientific journal)

  49. Toll-like receptor 9 trafficking and signaling for type i interferons requires PIKfyve activity

    Kachiko Hayashi, Miwa Sasai, Akiko Iwasaki

    International Immunology　Vol. 27　No. 9　p. 435-445　2015/09/01　Research paper (scientific journal)

  50. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii

    Jun Ohshima, Miwa Sasai, Jianfa Liu, Kazuo Yamashita, Ji Su Ma, Youngae Lee, Hironori Bando, Jonathan C. Howard, Shigeyuki Ebisu, Mikako Hayashi, Kiyoshi Takeda, Daron M. Standley, Eva Maria Frickel, Masahiro Yamamoto

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 112　No. 33　p. E4581-E4590　2015/08/18　Research paper (scientific journal)

  51. インターフェロンγ誘導性GTPaseとトキソプラズマ感染防御

    大嶋 淳, 笹井美和, 山本雅裕

    医学のあゆみ　Vol. 249　No. 13　p. 1325-1326　2014/09　Research paper (scientific journal)

  52. Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii

    Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira, Masahiro Yamamoto

    Journal of Immunology　Vol. 192　No. 7　p. 3328-3335　2014/04　Research paper (scientific journal)

  53. Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

    Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J. Ishii, Shizuo Akira, Toru Okamoto, Yoshiharu Matsuura

    Journal of Virology　Vol. 88　No. 4　p. 2157-2167　2014/02　Research paper (scientific journal)

  54. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    Journal of Experimental Medicine　Vol. 211　No. 10　p. 2013-2032　2014　Research paper (scientific journal)

  55. Pathogen recognition receptors: Ligands and signaling pathways by toll-like receptors

    Miwa Sasai, Masahiro Yamamoto

    International Reviews of Immunology　Vol. 32　No. 2　p. 116-133　2013/04

  56. CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock

    Naganori Kamiyama, Masahiro Yamamoto, Hiroyuki Saiga, Ji Su Ma, Jun Ohshima, Sakaaki Machimura, Miwa Sasai, Taishi Kimura, Yoshiyasu Ueda, Hisako Kayama, Kiyoshi Takeda

    PLoS ONE　Vol. 8　No. 2　2013/02/07　Research paper (scientific journal)

  57. Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

    Jill Henault, Jennifer Martinez, Jeffrey M. Riggs, Jane Tian, Payal Mehta, Lorraine Clarke, Miwa Sasai, Eicke Latz, Melanie M. Brinkmann, Akiko Iwasaki, Anthony J. Coyle, Roland Kolbeck, Douglas R. Green, Miguel A. Sanjuan

    Immunity　Vol. 37　No. 6　p. 986-997　2012/12/14　Research paper (scientific journal)

  58. A cluster of interferon-γ-inducible p65 gtpases plays a critical role in host defense against toxoplasma gondii

    Masahiro Yamamoto, Megumi Okuyama, Ji Su Ma, Taishi Kimura, Naganori Kamiyama, Hiroyuki Saiga, Jun Ohshima, Miwa Sasai, Hisako Kayama, Toru Okamoto, David C.S. Huang, Dominique Soldati-Favre, Kyoji Horie, Junji Takeda, Kiyoshi Takeda

    Immunity　Vol. 37　No. 2　p. 302-313　2012/08/24　Research paper (scientific journal)

  59. Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signaling and Antigen Presentation to CD4+ T Cells

    Adriana R. Mantegazza, Susan H. Guttentag, Jamel El-Benna, Miwa Sasai, Akiko Iwasaki, Hao Shen, Terri M. Laufer, Michael S. Marks

    Immunity　Vol. 36　No. 5　p. 782-794　2012/05/25　Research paper (scientific journal)

  60. Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction

    Miwa Sasai, Akiko Iwasaki

    Immunity　Vol. 35　No. 1　p. 3-5　2011/07/22　Research paper (scientific journal)

  61. Bifurcation of toll-like receptor 9 signaling by adaptor protein 3

    Miwa Sasai, Melissa M. Linehan, Akiko Iwasaki

    Science　Vol. 329　No. 5998　p. 1530-1534　2010/09/17　Research paper (scientific journal)

  62. Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

    Miwa Sasai, Megumi Tatematsu, Hiroyuki Oshiumi, Kenji Funami, Misako Matsumoto, Shigetsugu Hatakeyama, Tsukasa Seya

    Molecular Immunology　Vol. 47　No. 6　p. 1283-1291　2010/03　Research paper (scientific journal)

  63. Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-κB activation and type I IFN induction

    Hiromi Takaki, Hiroyuki Oshiumi, Miwa Sasai, Takahiro Kawanishi, Misako Matsumoto, Tsukasa Seya

    European Journal of Immunology　Vol. 39　No. 12　p. 3469-3476　2009/12　Research paper (scientific journal)

  64. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

    Michal Caspi Tal, Miwa Sasai, Heung Kyu Lee, Brian Yordy, Gerald S. Shadel, Akiko Iwasaki

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 8　p. 2774-2775　2009/02/24　Research paper (scientific journal)

  65. Homo-oligomerization is essential for toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-κB and interferon regulatory factor-3 activation

    Kenji Funami, Miwa Sasai, Hiroyuki Oshiumi, Tsukasa Seya, Misako Matsumoto

    Journal of Biological Chemistry　Vol. 283　No. 26　p. 18283-18291　2008/06/27　Research paper (scientific journal)

  66. Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction

    Masashi Shingai, Masahiro Azuma, Takashi Ebihara, Miwa Sasai, Kenji Funami, Minoru Ayata, Hisashi Ogura, Hiroyuki Tsutsumi, Misako Matsumoto, Tsukasa Seya

    International Immunology　Vol. 20　No. 9　p. 1169-1180　2008　Research paper (scientific journal)

  67. Spatiotemporal mobilization of toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA

    Kenji Funami, Miwa Sasai, Yusuke Ohba, Hiroyuki Oshiumi, Tsukasa Seya, Misako Matsumoto

    Journal of Immunology　Vol. 179　No. 10　p. 6867-6872　2007/11/15　Research paper (scientific journal)

  68. Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors

    Takashi Akazawa, Masashi Shingai, Miwa Sasai, Takashi Ebihara, Norimitsu Inoue, Misako Matsumoto, Tsukasa Seya

    FEBS Letters　Vol. 581　No. 18　p. 3334-3340　2007/07/24　Research paper (scientific journal)

  69. C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission

    Eiko Takada, Satoyo Okahira, Miwa Sasai, Kenji Funami, Tsukasa Seya, Misako Matsumoto

    Molecular Immunology　Vol. 44　No. 15　p. 3633-3640　2007/07　Research paper (scientific journal)

  70. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction

    Miwa Sasai, Masashi Shingai, Kenji Funami, Mitsutoshi Yoneyama, Takashi Fujita, Misako Matsumoto, Tsukasa Seya

    Journal of Immunology　Vol. 177　No. 12　p. 8676-8683　2006/12/15　Research paper (scientific journal)

  71. The kinase complex responsible for IRF-3-mediated IFN-β production in myeloid dendritic cells (mDC)

    Miwa Sasai, Misako Matsumoto, Tsukasa Seya

    Journal of Biochemistry　Vol. 139　No. 2　p. 171-175　2006/02

  72. TICAM-1 and TICAM-2: Toll-like receptor adapters that participate in induction of type 1 interferons

    Tsukasa Seya, Hiroyuki Oshiumi, Miwa Sasai, Takashi Akazawa, Misako Matsumoto

    International Journal of Biochemistry and Cell Biology　Vol. 37　No. 3　p. 524-529　2005/03　Research paper (scientific journal)

  73. Cutting edge: NF-κB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation

    Miwa Sasai, Hiroyuki Oshiumi, Misako Matsumoto, Norimitsu Inoue, Fumitaka Fujita, Makoto Nakanishi, Tsukasa Seya

    Journal of Immunology　Vol. 174　No. 1　p. 27-30　2005/01/01　Research paper (scientific journal)

  74. TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

    Hiroyuki Oshiumi, Miwa Sasai, Kyoko Shida, Takashi Fujita, Misako Matsumoto, Tsukasa Seya

    Journal of Biological Chemistry　Vol. 278　No. 50　p. 49751-49762　2003/12/12　Research paper (scientific journal)

Misc. 3

  1. Gate-16 is required for LC3-independent antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases

    Miwa Sasai, Masahiro Yamamoto

    CYTOKINE　Vol. 100　p. 29-29　2017/12　Research paper, summary (international conference)

  2. LC3-associated phagocytosis mediates IFN-alpha secretion in response to DNA-immune complexes.

    Payal Mehta, Jill Henault, Jennifer Martinez, Jeffery Riggs, Jane Tian, Lorraine Clarke, Miwa Sasai, Eicke Latz, Melanie Brinkmann, Akiko Lwasaki, Anthony Coyle, Roland Kolbeck, Douglas Green, Miguel Sanjuan

    JOURNAL OF IMMUNOLOGY　Vol. 192　2014/05　Research paper, summary (international conference)

  3. RLR signaling is amplified by reactive oxygen species and dysfunctions in autophagy

    Michal Tal, Miwa Sasai, Akiko Iwasaki

    JOURNAL OF IMMUNOLOGY　Vol. 186　2011/04　Research paper, summary (international conference)

Publications 2

  1. マウス表現型解析スタンダード

    笹井 美和, 山本 雅裕

    羊土社　2016/12　Textbook, survey, introduction

    ISBN: 9784758101981

  2. インターフェロンγ誘導性GTPaseとトキソプラズマ感染防御

    大嶋淳, 笹井美和, 山本雅裕

    医学のあゆみ　2014/06

Presentations 30

  1. Uncovering a novel role of PLCb in selectively mediating TCR signaling in CD8+ but not CD4+ T cells

    笹井 美和

    第43回 分子生物学会・ワークショップ (口頭）　2020/12

  2. PLCβ plays an important role in CD8 T cell-mediated host defense against Toxoplasma gondii

    Ji Su Ma, Miwa Sasai, Youngae Lee, Naoya Sakaguchi, Hironori Bando, Masahiro Yamamoto

    第46回 日本免疫学会学術集会　2017/12/12

  3. Role of GABARAP subfamily in the regulation of non-canonical inflammasome activation

    Naoya Sakaguchi, Ji Su Ma, Youngae Lee, Hironori Bando, Miwa Sasai, Masahiro Yamamoto

    第46回 日本免疫学会学術集会　2017/12/12

  4. Critical roles of GABARAPs on interferon-mediated cell-autonomous immune responses against T. gondii infection

    Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Youngae Lee, Hironori Bando, Shizuo Akira, Masahiro Yamamoto

    第46回 日本免疫学会学術集会　2017/12/12

  5. Gate-16 is required for LC3-independent antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases

    Sasai Miwa, Yamamoto Masahiro

    CYTOKINE2017　2017/10/29

  6. The Mammalian Atg8 Gabarap Subfamily Play a Non-Redundant Key Role in IFN-γ-Inducible GTPase-Dependent Host Defense Against Vacuolar Pathogens

    2017/09/05

  7. The role of Atg8 family on IFN-gamma-induced cell autonomous immune responses

    The 3rd Annual Meeting of Japanese Society of Osteoimmunology 2017 ISHIGAKI　2017/06/27

  8. GABARAPs are required for the LC3-Independent antimicrobial host defense through cytosolic distribution of Interferon-Inducible GTPases

    2017/05/29

  9. Essential role of Gate-16 in anti-Toxoplasma gondii immune response

    Miwa Sasai, Ji Su Ma, Youngae Lee, Hironori Bando, Masahiro Yamamoto

    第10回 寄生虫感染免疫研究会　2017/02

  10. The Atg8 family members play a critical role in non-autophagic cell-autonomous immunity to vacuolar pathogens

    Miwa Sasai, Naoya Sakaguchi, Masahiro Yamamoto

    Keystome symposia　2016/12/04

  11. A mechanism for interferon-γ-induced ubiquitin decoration of Toxoplasma gondii parasitophorous vacuoles

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Hironori Bando, Ariel Pradipta, Masahiro Yamamoto

    Forum Cheju18 Korea-Japan Parasitologists’Seminar　2016/10/28

  12. オートファジーアダプター分子p62はインターフェロンγ誘導性のトキソプラズマの寄生胞抗原の提示に特異的に関与する

    山本雅裕, 李栄愛, 笹井美和, 馬知秀, 伴戸博徳, 坂口直哉

    第85回 日本寄生虫学会大会　2016/03/19

  13. ヒト細胞におけるIFNγ依存的な抗トキソプラズマ応答にはIDO2ではなくIDO1が重要な役割を果たす

    伴戸 寛徳, 笹井 美和, 馬 知秀, 李 英愛, 坂口 直哉, 山本 雅裕

    第85回 日本寄生虫学会大会　2016/03/19

  14. p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto

    2015/11/18

  15. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii

    Miwa Sasai, Jun Ohshima, Ji Su Ma, Youngae Lee, Kiyoshi Takeda, Masahiro Yamamoto

    The 44th Annual Meeting of The Japanese Society for Immunology　2015/11/18

  16. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    Forum Cheju17　2015/11/13

  17. p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen

    Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto

    Forum Cheju17　2015/11/13

  18. トキソプラズマ原虫の多型濃縮顆粒タンパク質GRA6による選択的NFAT4の活性化について

    馬 知秀, 笹井 美和, 大嶋 淳, 李 英愛, 伴戸 寛徳, 竹田 潔, 山本 雅裕

    第84回日本寄生虫学会大会　2015/03/21

  19. 肝臓期マラリア原虫を標的とした新規抗マラリア薬の開発

    伴戸 寛徳, 笹井 美和, 馬 知秀, 大嶋 淳, 李 英愛, 山本 雅裕

    第84回日本寄生虫学会大会　2015/03/21

  20. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    第8回 寄生虫感染免疫研究会　2015/02/28

  21. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous host defense against Toxoplasma gondii

    Jun Ohshima, Miwa Sasai, Ji Su Ma, Youngae Lee, Hironori Bando, Kiyoshi Takeda, Masahiro Yamamoto

    第8回 寄生虫感染免疫研究会　2015/02/28

  22. Human ATG16L1 and GBPs are dispensable for IFN-γ–dependent anti–Toxoplasma gondii responses

    Youngae Lee, Jun Ohshima, Miwa Sasai, Ji Su Ma, Masahiro Yamamoto

    2014/12

  23. Role of mouse autophagy proteins in IFN-γ-mediated cell-autonomous responses against Toxoplasma gondii.

    Ohshima J, Sasai M, Ma JiSu, Lee Y, Takeda K, Yamamoto M

    2014/12

  24. Toxoplasma gondii GRA6 selectively activates NFAT4 to induce chemokine CXCL2 and CCL2

    Sasai M, Ma JiSu, Ohshima J, Lee Y, Takeda K, Yamamoto M

    2014/12

  25. インターフェロン-γ;誘導性 GTPaseによるトキソプラズマ原虫殺傷機構について

    山本雅裕, 大嶋淳, Lee Youngae, 笹井美和

    2014/10

  26. Identification of natural compounds that inhibit growth of intracellular pathogens.

    Bui XT, Sasai M, Yamamoto M, Koburi T, Nagai H

    2014/09

  27. Activation of host NFAT by a Toxoplasmagondii polymorphic dense granule protein plays an important role in virulence mediated by the local infection

    Yamamoto M, Ma JS, Ohshima J, Sasai M

    2014/04

  28. IFN-γ依存的抗トキソプラズマ応答におけるオートファジー蛋白質の役割

    Yamamoto M, Oshima J, Su Ma J, Lee Y

    2014/03

  29. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6

    Ma JS, Sasai M, Takeda K, Yamamoto M

    2013/12

  30. インターフェロンガンマ依存性の細胞内侵入病原体排除におけるオートファジー関連タンパク質の役割の解明

    Jun Ooshima, Miwa Sasai, Masahiro Yamamot, Mikamo Hayashi

    2013/06

Media Coverage 2

  1. C型肝炎ウイルス、薬剤耐性なく治療する化合物 阪大、アルツハイ マー病治療薬の候補の中に...トキソプラズマなども効果

    産経新聞

    2017/11

  2. トキソプラズマ『トロイの木馬』現象 原因タンパク質 確認

    読売新聞

    2014/09

Institutional Repository 4

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production

    Nakayama Yuki, Ihara Fumiaki, Okuzaki Daisuke, Nishikawa Yoshifumi, Sasai Miwa, Yamamoto Masahiro

    Parasitology International　Vol. 105　2025/04/01

  2. CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma

    Tachibana Yuta, Sasai Miwa, Yamamoto Masahiro

    mBio　Vol. 15　No. 9　2024/07/31

  3. Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages

    Ihara Fumiaki, Kyan Hisako, Takashima Yasuhiro, Ono Fumiko, Hayashi Kei, Matsuo Tomohide, Igarashi Makoto, Nishikawa Yoshifumi, Hikosaka Kenji, Sakamoto Hirokazu, Nakamura Shota, Motooka Daisuke, Yamauchi Kiyoshi, Ichikawa-Seki Madoka, Fukumoto Shinya, Sasaki Motoki, Ikadai Hiromi, Kusakisako Kodai, Ohari Yuma, Yoshida Ayako, Sasai Miwa, Grigg Michael E., Yamamoto Masahiro

    Nature Communications　Vol. 15　2024/05/22

  4. Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens

    Tachibana Yuta, Hashizaki Emi, Sasai Miwa, Yamamoto Masahiro

    Cell Reports　Vol. 42　No. 6　2023/06/27