(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.

Rei Yokoyama, Yukio Ago, Hisato Igarashi, Momoko Higuchi, Masato Tanuma, Yuto Shimazaki, Takafumi Kawai, Kaoru Seiriki, Misuzu Hayashida, Shun Yamaguchi, Hirokazu Tanaka, Takanobu Nakazawa, Yasushi Okamura, Kenji Hashimoto, Atsushi Kasai, Hitoshi Hashimoto

Molecular psychiatry　2024/02/23　Research paper (scientific journal)

Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice.

Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Hisato Igarashi, Kaoru Seiriki, Takanobu Nakazawa, Atsushi Kasai, Yukio Ago, Hitoshi Hashimoto

Journal of pharmacological sciences　Vol. 154　No. 2　p. 72-76　2024/02　Research paper (scientific journal)

Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner.

Yumi Hirato, Kaoru Seiriki, Leo Kojima, Shohei Yamada, Hiroki Rokujo, Tomoya Takemoto, Takanobu Nakazawa, Atsushi Kasai, Hitoshi Hashimoto

Biological & pharmaceutical bulletin　Vol. 47　No. 2　p. 478-485　2024　Research paper (scientific journal)

胎生期PGD2-DP1シグナル活性化はマウスの自閉症様の精神行動異常を引き起こす

村田 拳一朗, 早田 敦子, 菊池 泰河, 岩橋 美咲, 毛利 育子, 橘 雅弥, 田熊 一敞, 片山 泰一, 谷池 雅子, 橋本 均

日本脳科学会プログラム・抄録集　Vol. 50回　p. np18-np18　2023/12

胎生期PGD2-DP1シグナル活性化はマウスの自閉症様の精神行動異常を引き起こす

村田 拳一朗, 早田 敦子, 菊池 泰河, 岩橋 美咲, 毛利 育子, 橘 雅弥, 田熊 一敞, 片山 泰一, 谷池 雅子, 橋本 均

日本脳科学会プログラム・抄録集　Vol. 50回　p. np18-np18　2023/12

Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo

Taro Ichimura, Taishi Kakizuka, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

2023/08/22

Pituitary Adenylate Cyclase-Activating Polypeptide deficient mice show length abnormalities of the axon initial segment

Misaki Iwahashi, Takeshi Yoshimura, Wakana Harigai, Kazuhiro Takuma, Hitoshi Hashimoto, Taiichi Katayama, Atsuko Hayata-Takano

Journal of Pharmacological Sciences　2023/08　Research paper (scientific journal)

Decreased Expression of EP3 Receptor mRNA in the Brain of Mouse Model of Autism Spectrum Disorder.

Kusnandar Anggadiredja, Neng Fisheri Kurniati, Atsushi Kasai, Hitoshi Hashimoto

MicroRNA (Shariqah, United Arab Emirates)　2023/04/27　Research paper (scientific journal)

Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway

Satoshi Asano, Ami Ono, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Kotaro Tanimoto, Hitoshi Hashimoto, Yukio Ago

Peptides　Vol. 161　p. 170940-170940　2023/03　Research paper (scientific journal)

Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience.

Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko

Cell reports　Vol. 42　No. 3　p. 112149-112149　2023/02/22　Research paper (scientific journal)

Effect of PACAP on Heat Exposure.

Keisuke Suzuki, Hiroki Yamaga, Hirokazu Ohtaki, Satoshi Hirako, Kazuyuki Miyamoto, Motoyasu Nakamura, Kaoru Yanagisawa, Takuya Shimada, Tomohiko Hosono, Hitoshi Hashimoto, Kazuho Honda, Kenji Dohi

International journal of molecular sciences　Vol. 24　No. 4　2023/02/16　Research paper (scientific journal)

High-throughput line-illumination Raman microscopy with multislit detection

Kentaro Mochizuki, Yasuaki Kumamoto, Shunsuke Maeda, Masato Tanuma, Atsushi Kasai, Masashi Takemura, Yoshinori Harada, Hitoshi Hashimoto, Hideo Tanaka, Nicholas Isaac Smith, Katsumasa Fujita

Biomedical Optics Express　Vol. 14　No. 3　p. 1015-1015　2023/02/07　Research paper (scientific journal)

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.

Maho Eguchi, Seiya Hirata, Ikuho Ishigami, Naomi Shuwari, Ryosuke Ono, Masashi Tachibana, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-Ichi Ogawara, Hiroyuki Mizuguchi, Fuminori Sakurai

Journal of controlled release : official journal of the Controlled Release Society　Vol. 354　p. 35-44　2023/02　Research paper (scientific journal)

Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.

Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M Watabe

Nature communications　Vol. 13　No. 1　p. 7913-7913　2022/12/30　Research paper (scientific journal)

Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala.

Masato Tanuma, Misaki Niu, Jin Ohkubo, Hiroki Ueno, Yuka Nakai, Yoshihisa Yokoyama, Kaoru Seiriki, Hitoshi Hashimoto, Atsushi Kasai

Molecular brain　Vol. 15　No. 1　p. 100-100　2022/12/20　Research paper (scientific journal)

Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice.

Yusuke Shintani, Atsuko Hayata-Takano, Yui Yamano, Manato Ikuta, Rei Takeshita, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara, Hitoshi Hashimoto

Biochemical and Biophysical Research Communications　Vol. 631　p. 146-151　2022/11/26　Research paper (scientific journal)

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Fumito Endo, Atsushi Kasai, Joselyn S. Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, Baljit S. Khakh

Science　Vol. 378　No. 6619　2022/11/04　Research paper (scientific journal)

Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites.

Yukio Ago, Rei Yokoyama, Satoshi Asano, Hitoshi Hashimoto

Neuropharmacology　p. 109313-109313　2022/10/31　Research paper (scientific journal)

The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus.

Yuki Kambe, Thanh Trung Nguyen, Toshiharu Yasaka, Thu Thi Nguyen, Yoshimune Sameshima, Kohei Hashiguchi, Norihito Shintani, Hitoshi Hashimoto, Takashi Kurihara, Atsuro Miyata

Molecular neurobiology　Vol. 60　No. 1　p. 171-182　2022/10/17　Research paper (scientific journal)

Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice.

Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner

International journal of molecular sciences　Vol. 23　No. 19　2022/10/03　Research paper (scientific journal)

Autism-associated ANK2 regulates embryonic neurodevelopment.

Shotaro Kawano, Masayuki Baba, Hotaka Fukushima, Daiki Miura, Hitoshi Hashimoto, Takanobu Nakazawa

Biochemical and biophysical research communications　Vol. 605　p. 45-50　2022/05/21　Research paper (scientific journal)

Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 15　No. 1　p. 34-34　2022/04/11　Research paper (scientific journal)

Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.

Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, Norio Ozaki, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 15　No. 1　p. 26-26　2022/03/28　Research paper (scientific journal)

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.

Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto

Science advances　Vol. 8　No. 11　2022/03/18　Research paper (scientific journal)

Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy.

Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner

Frontiers in endocrinology　Vol. 13　p. 995900-995900　2022　Research paper (scientific journal)

Vasoactive intestinal peptide-VIPR2 signaling regulates tumor cell migration.

Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Hitoshi Hashimoto, James A Waschek, Yukio Ago

Frontiers in oncology　Vol. 12　p. 852358-852358　2022　Research paper (scientific journal)

The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy.

Timea Kvarik, Dora Reglodi, Dora Werling, Alexandra Vaczy, Petra Kovari, Edina Szabo, Krisztina Kovacs, Hitoshi Hashimoto, Tibor Ertl, Judit Gyarmati, Tamas Atlasz

Journal of molecular neuroscience : MN　Vol. 71　No. 12　p. 2546-2557　2021/12　Research paper (scientific journal)

Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia.

Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura, Kazuki Nagayasu, Yoshinori Tsurusaki, Noriko Miyake, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Mikiya Fujiwara, Masayuki Baba, Kohei Kitagawa, Tomoya Takemoto, Nanaka Gotoda-Nishimura, Tomohiro Takada, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Yukio Ago, Satoshi Kida, Kazuhiro Takuma, Fumihito Ono, Naomichi Matsumoto, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Translational psychiatry　Vol. 11　No. 1　p. 548-548　2021/10/25　Research paper (scientific journal)

Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro.

Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki, Yonehiro Kanemura

Molecular brain　Vol. 14　No. 1　p. 149-149　2021/10/11　Research paper (scientific journal)

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory.

Yuki Kambe, Yu Yamauchi, Trung Thanh Nguyen, Thu Thi Nguyen, Yukio Ago, Norihito Shintani, Hitoshi Hashimoto, Shimako Yoshitake, Takashi Yoshitake, Jan Kehr, Namiko Kawamura, Goro Katsuura, Takashi Kurihara, Atsuro Miyata

Pharmacological reports : PR　Vol. 73　No. 4　p. 1109-1121　2021/08　Research paper (scientific journal)

Exploring rare cellular activity in more than one million cells by a transscale scope

T. Ichimura, T. Kakizuka, K. Horikawa, K. Seiriki, A. Kasai, H. Hashimoto, K. Fujita, T. M. Watanabe, T. Nagai

SCIENTIFIC REPORTS　Vol. 11　No. 1　2021/08　Research paper (scientific journal)

Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.

Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-Ichiro Kubo, Kazunori Nakajima

iScience　Vol. 24　No. 4　p. 102277-102277　2021/04/23　Research paper (scientific journal)

Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder.

Kohei Kitagawa, Kensuke Matsumura, Masayuki Baba, Momoka Kondo, Tomoya Takemoto, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Molecular brain　Vol. 14　No. 1　p. 56-56　2021/03/16　Research paper (scientific journal)

Altered Functional Connectivity of the Orbital Cortex and Striatum Associated with Catalepsy Induced by Dopamine D1 and D2 Antagonists

Misaki Niu, Atsushi Kasai, Kaoru Seiriki, Misuzu Hayashida, Masato Tanuma, Rei Yokoyama, Yumi Hirato, Hitoshi Hashimoto

Biological and Pharmaceutical Bulletin　Vol. 44　No. 3　p. 442-447　2021/03/01　Research paper (scientific journal)

Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models.

Yukio Ago, Satoshi Asano, Hitoshi Hashimoto, James A Waschek

Frontiers in neuroscience　Vol. 15　p. 717490-717490　2021　Research paper (scientific journal)

PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.

Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Hitoshi Hashimoto

Frontiers in endocrinology　Vol. 12　p. 732456-732456　2021　Research paper (scientific journal)

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice.

Chihiro Kawaguchi, Norihito Shintani, Atsuko Hayata-Takano, Michiyoshi Hatanaka, Ai Kuromi, Reiko Nakamura, Yui Yamano, Yusuke Shintani, Katsuya Nagai, Soken Tsuchiya, Yukihiko Sugimoto, Atsushi Ichikawa, Yasushi Okuno, Yoshihiro Urade, Hiroyuki Hirai, Kin-Ya Nagata, Masataka Nakamura, Shuh Narumiya, Takanobu Nakazawa, Atsushi Kasai, Yukio Ago, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto

Communications biology　Vol. 3　No. 1　p. 557-557　2020/10/08　Research paper (scientific journal)

Trans-scale-scope to find rare cellular activity in sub-million cells

Taro Ichimura, Taishi Kakizuka, Kazuki Horikawa, Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto, Katsumasa Fujita, Tomonobu M. Watanabe, Takeharu Nagai

2020/06/30

Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice.

Thanh Trung Nguyen, Yuki Kambe, Takashi Kurihara, Tomoya Nakamachi, Norihito Shintani, Hitoshi Hashimoto, Atsuro Miyata

Molecular neurobiology　Vol. 57　No. 4　p. 2101-2114　2020/04　Research paper (scientific journal)

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.

Rei Yokoyama, Momoko Higuchi, Wataru Tanabe, Shinji Tsukada, Megumi Naito, Takumi Yamaguchi, Lu Chen, Atsushi Kasai, Kaoru Seiriki, Takanobu Nakazawa, Shinsaku Nakagawa, Kenji Hashimoto, Hitoshi Hashimoto, Yukio Ago

Pharmacology, biochemistry, and behavior　Vol. 191　p. 172876-172876　2020/04　Research paper (scientific journal)

Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain.

Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto

JCI insight　Vol. 5　No. 6　2020/03/26　Research paper (scientific journal)

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.

Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Kazuki Nagayasu, Kana Yamamoto, Kohei Kitagawa, Hiroki Miura, Nanaka Gotoda-Nishimura, Hisato Igarashi, Misuzu Hayashida, Masayuki Baba, Momoka Kondo, Shigeru Hasebe, Kosei Ueshima, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Tokuichi Iguchi, Makoto Sato, Shun Yamaguchi, Masaru Tamura, Shigeharu Wakana, Atsushi Yoshiki, Ayako M Watabe, Hideyuki Okano, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Nature communications　Vol. 11　No. 1　p. 859-859　2020/02/26　Research paper (scientific journal)

Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism.

Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Kazuhiro Takuma, James A Waschek, Hitoshi Hashimoto, Yukio Ago

Frontiers in neuroscience　Vol. 14　p. 521-521　2020　Research paper (scientific journal)

Autism-associated protein kinase D2 regulates embryonic cortical neuron development.

Kensuke Matsumura, Masayuki Baba, Kazuki Nagayasu, Kana Yamamoto, Momoka Kondo, Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Toshihiko Kuriu, Tokuichi Iguchi, Makoto Sato, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Biochemical and biophysical research communications　Vol. 519　No. 3　p. 626-632　2019/11/12　Research paper (scientific journal)

Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.

Masayuki Baba, Kazumasa Yokoyama, Kaoru Seiriki, Yuichiro Naka, Kensuke Matsumura, Momoka Kondo, Kana Yamamoto, Misuzu Hayashida, Atsushi Kasai, Yukio Ago, Kazuki Nagayasu, Atsuko Hayata-Takano, Akinori Takahashi, Shun Yamaguchi, Daisuke Mori, Norio Ozaki, Tadashi Yamamoto, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology　Vol. 44　No. 12　p. 2125-2135　2019/11　Research paper (scientific journal)

Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.

Daniel Balazs Fulop, Viktoria Humli, Judit Szepesy, Virag Ott, Dora Reglodi, Balazs Gaszner, Adrienn Nemeth, Agnes Szirmai, Laszlo Tamas, Hitoshi Hashimoto, Tibor Zelles, Andrea Tamas

Scientific reports　Vol. 9　No. 1　p. 14598-14598　2019/10/10　Research paper (scientific journal)

(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism.

Yukio Ago, Wataru Tanabe, Momoko Higuchi, Shinji Tsukada, Tatsunori Tanaka, Takumi Yamaguchi, Hisato Igarashi, Rei Yokoyama, Kaoru Seiriki, Atsushi Kasai, Takanobu Nakazawa, Shinsaku Nakagawa, Kenji Hashimoto, Hitoshi Hashimoto

The international journal of neuropsychopharmacology　Vol. 22　No. 10　p. 665-674　2019/10/01　Research paper (scientific journal)

Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies.

Takanobu Nakazawa, Ryota Hashimoto, Kazuhiro Takuma, Hitoshi Hashimoto

Journal of pharmacological sciences　Vol. 140　No. 4　p. 321-324　2019/08　Research paper (scientific journal)

Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice

B. D. Fulop, B. Sandor, E. Szentleleky,E. Karanyicz, D. Reglodi, B. Gaszner, R. Zakany, H.Hashimoto, T. Juhasz, A. Tamas

Journal of Molecular Neuroscience　2019/07

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.

Atsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A Waschek, Hitoshi Hashimoto

The Journal of neuroscience : the official journal of the Society for Neuroscience　Vol. 39　No. 22　p. 4208-4220　2019/05/29　Research paper (scientific journal)

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.

Kaoru Seiriki, Atsushi Kasai, Takanobu Nakazawa, Misaki Niu, Yuichiro Naka, Masato Tanuma, Hisato Igarashi, Kosei Yamaura, Atsuko Hayata-Takano, Yukio Ago, Hitoshi Hashimoto

Nature protocols　Vol. 14　No. 5　p. 1509-1529　2019/05　Research paper (scientific journal)

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.

Naoya Nishitani, Kazuki Nagayasu, Nozomi Asaoka, Mayumi Yamashiro, Chihiro Andoh, Yuma Nagai, Haruko Kinoshita, Hiroyuki Kawai, Norihiro Shibui, Beihui Liu, James Hewinson, Hisashi Shirakawa, Takayuki Nakagawa, Hitoshi Hashimoto, Sergey Kasparov, Shuji Kaneko

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology　Vol. 44　No. 4　p. 721-732　2019/03　Research paper (scientific journal)

Enriched environment restrains autism spectrum disorder-like phenotypes in mice prenatally exposed to valproic acid.

Takuma Kazuhiro, Yamaguchi Hiroshi, Hara Yuta, Ago Yukio Ago, Kita-Takano Erika, Hasebe Shigeru, Nakazawa Takanobu, Hashimoto Hitoshi, Matsuda Toshio

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　No. 0　p. 3-P-022　2019

Treatment of pregnant mice with valproic acid caused an increase in miR-132 levels in the embryonic brain.

Nakazawa Takanobu, Hara Yuta, Ago Yukio, Kita-Takano Erika, Hasebe Shigeru, Hashimoto Hitoshi, Matsuda Toshio, Takuma Kazuhiro

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　No. 0　p. 3-P-023　2019

[Whole-brain activity mapping at single-cell resolution].

Atsushi Kasai, Kaoru Seiriki, Hitoshi Hashimoto

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 153　No. 6　p. 278-283　2019　Research paper (scientific journal)

Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.

Jiang Li, Hitoshi Hashimoto, Herbert Y Meltzer

Frontiers in psychiatry　Vol. 10　p. 58-58　2019　Research paper (scientific journal)

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.

Haruki Kawase, Yukio Ago, Megumi Naito, Momoko Higuchi, Yuta Hara, Shigeru Hasebe, Shinji Tsukada, Atsushi Kasai, Takanobu Nakazawa, Tadashi Mishina, Hiroyuki Kouji, Kazuhiro Takuma, Hitoshi Hashimoto

Pharmacology, biochemistry, and behavior　Vol. 176　p. 1-5　2019/01　Research paper (scientific journal)

VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice.

Ivan Ivic, Marta Balasko, Balazs D Fulop, Hitoshi Hashimoto, Gabor Toth, Andrea Tamas, Tamas Juhasz, Akos Koller, Dora Reglodi, Margit Solymár

PloS one　Vol. 14　No. 1　2019　Research paper (scientific journal)

Saturated excitation microscopy using differential excitation for efficient detection of nonlinear fluorescence signals

Yasunori Nawa, Yasuo Yonemaru, Atsushi Kasai, Ryosuke Oketani, Hitoshi Hashimoto, Nicholas I. Smith, Katsumasa Fujita

APL Photonics　Vol. 3　No. 8　p. 080805-080805　2018/08　Research paper (scientific journal)

Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.

Dora Reglodi, Adel Jungling, Rémi Longuespée, Joerg Kriegsmann, Rita Casadonte, Mark Kriegsmann, Tamas Juhasz, Sebastian Bardosi, Andrea Tamas, Balazs Daniel Fulop, Krisztina Kovacs, Zsuzsanna Nagy, Jason Sparks, Attila Miseta, Gabriel Mazzucchelli, Hitoshi Hashimoto, Attila Bardosi

The Journal of pathology　Vol. 245　No. 4　p. 478-490　2018/08　Research paper (scientific journal)

Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism

Naoki Inoue, Sae Ogura, Atsushi Kasai, Takanobu Nakazawa, Kazuya Ikeda, Shintaro Higashi, Ayako Isotani, Kousuke Baba, Hideki Mochizuki, Harutoshi Fujimura, Yukio Ago, Atsuko Hayata-Takano, Kaoru Seiriki, Yusuke Shintani, Norihito Shintani, Hitoshi Hashimoto

EMBO Reports　Vol. 19　No. 3　2018/03/01　Research paper (scientific journal)

[Pathophysiological implication of the VPAC2 receptor in psychiatric disorders].

Ago Y, Hayata A, Hashimoto H

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 151　No. 6　p. 249-253　2018

Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient Mice

D. Reglodi, S. Cseh, B. Somoskoi, B. D. Fulop, E. Szentleleky, V. Szegeczki, A. Kovacs, A. Varga, P. Kiss, H. Hashimoto, A. Tamas, A. Bardosi, S. Manavalan, E. Bako, R. Zakany, T. Juhasz

Reproduction　Vol. 155　No. 2　p. 129-139　2018　Research paper (scientific journal)

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

Yusuke Shintani, Atsuko Hayata-Takano, Keita Moriguchi, Takanobu Nakazawa, Yukio Ago, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Hitoshi Hashimoto

PloS one　Vol. 13　No. 5　2018　Research paper (scientific journal)

Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response

Naoki Inoue, Taisei Hirouchi, Atsushi Kasai, Shintaro Higashi, Natsumi Hiraki, Shota Tanaka, Takanobu Nakazawa, Kazuto Nunomura, Bangzhong Lin, Akiko Omori, Atsuko Hayata-Takano, Yoon-Jeong Kim, Takefumi Doi, Akemichi Baba, Hitoshi Hashimoto, Norihito Shintani

Biochemical and Biophysical Research Communications　Vol. 495　No. 2　p. 1992-1997　2018/01　Research paper (scientific journal)

プロスタグランジンD2受容体DP1を介したマウス神経細胞の形態変化の解析

奥田健太, 早田敦子, 毛利育子, 新谷勇介, 加茂俊彦, 中澤敬信, 谷池雅子, 橋本均

Vol. 1　2017/11　Research paper (other academic)

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

Yuta Hara, Yukio Ago, Atsuki Taruta, Shigeru Hasebe, Haruki Kawase, Wataru Tanabe, Shinji Tsukada, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma

PSYCHOPHARMACOLOGY　Vol. 234　No. 21　p. 3217-3228　2017/11　Research paper (scientific journal)

Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism

Yuta Hara, Yukio Ago, Momoko Higuchi, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma

HORMONES AND BEHAVIOR　Vol. 96　p. 130-136　2017/11　Research paper (scientific journal)

Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice

Yukio Ago, Atsuko Hayata-Takano, Takuya Kawanai, Ryosuke Yamauchi, Shuto Takeuchi, Jesse D. Cushman, Abha K. Rajbhandari, Michael S. Fanselow, Hitoshi Hashimoto, James A. Waschek

NEUROBIOLOGY OF LEARNING AND MEMORY　Vol. 145　p. 222-231　2017/11　Research paper (scientific journal)

Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice

Hiroshi Yamaguchi, Yuta Hara, Yukio Ago, Erika Takano, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma

BEHAVIOURAL BRAIN RESEARCH　Vol. 333　p. 67-73　2017/08　Research paper (scientific journal)

Psychopharmacology of combined activation of the serotonin(1A) and sigma(1) receptors

Yukio Ago, Shigeru Hasebe, Naoki Hiramatsu, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 809　p. 172-177　2017/08　Research paper (scientific journal)

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

Kaoru Seiriki, Atsushi Kasai, Takeshi Hashimoto, Wiebke Schulze, Misaki Niu, Shun Yamaguchi, Takanobu Nakazawa, Ken-ichi Inoue, Shiori Uezono, Masahiko Takada, Yuichiro Naka, Hisato Igarashi, Masato Tanuma, James A. Waschek, Yukio Ago, Kenji F. Tanaka, Atsuko Hayata-Takano, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Hirooki Yabe, Takeharu Nagai, Katsumasa Fujita, Toshio Matsuda, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto

NEURON　Vol. 94　No. 6　p. 1085-+　2017/06　Research paper (scientific journal)

CONSTRUCT AND FACE VALIDITY OF A NEW MODEL FOR THE THREE-HIT THEORY OF DEPRESSION USING PACAP MUTANT MICE ON CD1 BACKGROUND

Jozsef Farkas, Laszlo A. Kovacs, Laszlo Gaspar, Anna Nafz, Tamas Gaszner, Balazs Ujvari, Viktoria Kormos, Valer Csernus, Hitoshi Hashimoto, Dora Reglodi, Balazs Gaszner

NEUROSCIENCE　Vol. 354　p. 11-29　2017/06　Research paper (scientific journal)

Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

Yuta Hara, Yukio Ago, Erika Takano, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma

MOLECULAR AUTISM　Vol. 8　2017/06　Research paper (scientific journal)

Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation

Makito Haruta, Naoya Kamiyama, Shun Nakajima, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Atsushi Yamasaki, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Yasuyuki Ishikawa, Takashi Tokuda, Hitoshi Hashimoto, Jun Ohta

JAPANESE JOURNAL OF APPLIED PHYSICS　Vol. 56　No. 5　2017/05　Research paper (scientific journal)

Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior

Yuki Fujita, Koji Masuda, Masashige Bando, Ryuichiro Nakato, Yuki Katou, Takashi Tanaka, Masahiro Nakayama, Keizo Takao, Tsuyoshi Miyakawa, Tatsunori Tanaka, Yukio Ago, Hitoshi Hashimoto, Katsuhiko Shirahige, Toshihide Yamashita

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 214　No. 5　p. 1431-1452　2017/05　Research paper (scientific journal)

Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice

Ivan Ivic, Balazs D. Fulop, Tamas Juhasz, Dora Reglodi, Gabor Toth, Hitoshi Hashimoto, Andrea Tamas, Akos Koller

Journal of Vascular Research　Vol. 54　No. 3　p. 180-192　2017/05/01　Research paper (scientific journal)

Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice

Tatsunori Tanaka, Yukio Ago, Chiaki Umehara, Emina Imoto, Shigeru Hasebe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　Vol. 20　No. 5　p. 410-421　2017/05　Research paper (scientific journal)

Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation

Makito Haruta, Naoya Kamiyama, Shun Nakajima, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Atsushi Yamasaki, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Yasuyuki Ishikawa, Takashi Tokuda, Hitoshi Hashimoto, Jun Ohta

JAPANESE JOURNAL OF APPLIED PHYSICS　Vol. 56　No. 5　2017/05　Research paper (scientific journal)

Early Neurobehavioral Development of Mice Lacking Endogenous PACAP

Jozsef Farkas, Balazs Sandor, Andrea Tamas, Peter Kiss, Hitoshi Hashimoto, Andras D. Nagy, Balazs D. Fulop, Tamas Juhasz, Sridharan Manavalan, Dora Reglodi

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 61　No. 4　p. 468-478　2017/04　Research paper (scientific journal)

Early Neurobehavioral Development of Mice Lacking Endogenous PACAP

Jozsef Farkas, Balazs Sandor, Andrea Tamas, Peter Kiss, Hitoshi Hashimoto, Andras D. Nagy, Balazs D. Fulop, Tamas Juhasz, Sridharan Manavalan, Dora Reglodi

Journal of Molecular Neuroscience　Vol. 61　No. 4　p. 468-478　2017/04/01　Research paper (scientific journal)

Astrocyte-neuron lactate shuttle, the major effector of astrocytic PACAP signaling for CNS functions

Kambe Yuki, Yokai Masafumi, Nakashima Yu, Shintani Norihito, Hashimoto Hitoshi, Takasaki Ichiro, Kurihara Takashi, Miyata Atsuro

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells frommonozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine

Takanobu Nakazawa, Masataka Kikuchi, Mitsuru Ishikawa, Hidenaga Yamamori, Kazuki Nagayasu, Takuya Matsumoto, Michiko Fujimoto, Yuka Yasuda, Mikiya Fujiwara, Shota Okada, Kensuke Matsumura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Shusuke Numata, Kazuhiro Takuma, Wado Akamatsu, Hideyuki Okano, Akihiro Nakaya, Hitoshi Hashimoto, Ryota Hashimoto

SCHIZOPHRENIA RESEARCH　Vol. 181　p. 75-82　2017/03　Research paper (scientific journal)

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia

Makoto Kinoshita, Shusuke Numata, Atsushi Tajima, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Shinya Watanabe, Hidehiro Umehara, Shinji Shimodera, Takanobu Nakazawa, Masataka Kikuchi, Akihiro Nakaya, Hitoshi Hashimoto, Issei Imoto, Ryota Hashimoto, Tetsuro Ohmori

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES　Vol. 18　No. 3　2017/03　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion

S. Sasaki, J. Watanabe, H. Ohtaki, M. Matsumoto, N. Murai, T. Nakamachi, J. Hannibal, J. Fahrenkrug, H. Hashimoto, H. Watanabe, H. Sueki, K. Honda, A. Miyazaki, S. Shioda

British Journal of Dermatology　Vol. 176　No. 2　p. 413-422　2017/02/01　Research paper (scientific journal)

Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice

S. Hasebe, Y. Ago, Y. Watabe, S. Oka, N. Hiramatsu, T. Tanaka, C. Umehara, H. Hashimoto, K. Takuma, T. Matsuda

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 174　No. 4　p. 314-327　2017/02　Research paper (scientific journal)

Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice

Ivan Ivic, Balazs D. Fulop, Tamas Juhasz, Dora Reglodi, Gabor Toth, Hitoshi Hashimoto, Andrea Tamas, Akos Koller

JOURNAL OF VASCULAR RESEARCH　Vol. 54　No. 3　p. 180-192　2017　Research paper (scientific journal)

Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice

Ivan Ivic, Margit Solymar, Balazs D. Fulop, Hitoshi Hashimoto, Gabor Toth, Andrea Tamas, Tamas Juhasz, Akos Koller, Dora Reglodi

JOURNAL OF VASCULAR RESEARCH　Vol. 54　No. 6　p. 359-366　2017　Research paper (scientific journal)

Prostaglandin D-2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction

Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Takuya Kanoh, Yukio Ago, Toshio Matsuda, Ryota Hashimoto, Kazutaka Ohi, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Atsuko Hayata-Takano, Kazuki Nagayasu, Kazuhiro Takuma, Asao Ogawa, Akemichi Baba, Hitoshi Hashimoto

BEHAVIOURAL BRAIN RESEARCH　Vol. 314　p. 77-86　2016/11　Research paper (scientific journal)

Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues

Atsushi Kasai, Sora Kakihara, Hiroki Miura, Ryo Okada, Atsuko Hayata-Takano, Keisuke Hazama, Misaki Niu, Norihito Shintani, Takanobu Nakazawa, Hitoshi Hashimoto

FRONTIERS IN MOLECULAR NEUROSCIENCE　Vol. 9　2016/11　Research paper (scientific journal)

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice

Kaoru Seiriki, Atsushi Kasai, Takahiro Kuwaki, Takanobu Nakazawa, Shun Yamaguchi, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 480　No. 4　p. 558-563　2016/11　Research paper (scientific journal)

Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation

Takuya Kawanai, Yukio Ago, Ryo Watanabe, Aya Inoue, Atsuki Taruta, Yusuke Onaka, Shigeru Hasebe, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma

NEUROCHEMICAL RESEARCH　Vol. 41　No. 10　p. 2574-2584　2016/10　Research paper (scientific journal)

Improvement by Methylphenidate and Atomoxetine of Social Interaction Deficits and Recognition Memory Impairment in a Mouse Model of Valproic Acid-Induced Autism

Yuta Hara, Yukio Ago, Atsuki Taruta, Keisuke Katashiba, Shigeru Hasebe, Erika Takano, Yusuke Onaka, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma

AUTISM RESEARCH　Vol. 9　No. 9　p. 926-939　2016/09　Research paper (scientific journal)

Involvement of GABA(A) receptors in 5-HT1A and sigma(1) receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

Yukio Ago, Shigeru Hasebe, Naoki Hiramatsu, Kazuya Mori, Yuji Watabe, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

PSYCHOPHARMACOLOGY　Vol. 233　No. 17　p. 3125-3134　2016/09　Research paper (scientific journal)

REDUCED RESPONSE TO CHRONIC MILD STRESS IN PACAP MUTANT MICE IS ASSOCIATED WITH BLUNTED FOSB EXPRESSION IN LIMBIC FOREBRAIN AND BRAINSTEM CENTERS

Viktoria Kormos, Laszlo Gaspar, Laszlo A. Kovacs, Jozsef Farkas, Tamas Gaszner, Valer Csernus, Andras Balogh, Hitoshi Hashimoto, Dora Reglodi, Zsuzsanna Helyes, Balazs Gaszner

NEUROSCIENCE　Vol. 330　p. 335-358　2016/08　Research paper (scientific journal)

PACAP suppresses dry eye signs by stimulating tear secretion.

Tomoya Nakamachi, Hirokazu Ohtaki, Tamotsu Seki, Sachiko Yofu, Nobuyuki Kagami, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Laszlo Mark, Ingela Lanekoff, Peter Kiss, Jozsef Farkas, Dora Reglodi, Seiji Shioda

Nature communications　Vol. 7　p. 12034-12034　2016/06/27　Research paper (scientific journal)

Structural and Morphometric Comparison of Lower Incisors in PACAP-Deficient and Wild-Type Mice

B. Sandor, K. Fintor, D. Reglodi, D. B. Fulop, Z. Helyes, I. Szanto, P. Nagy, H. Hashimoto, A. Tamas

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 59　No. 2　p. 300-308　2016/06　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Regulates the Hypothalamo-Pituitary-Thyroid (HPT) Axis via Type 2 Deiodinase in Male Mice

P. Egri, C. Fekete, A. Denes, D. Reglodi, H. Hashimoto, B. D. Fulop, Balazs Gereben

ENDOCRINOLOGY　Vol. 157　No. 6　p. 2356-2366　2016/06　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke.

Minako Matsumoto, Tomoya Nakamachi, Jun Watanabe, Koichi Sugiyama, Hirokazu Ohtaki, Norimitsu Murai, Shun Sasaki, Zhifang Xu, Hitoshi Hashimoto, Tamotsu Seki, Akira Miyazaki, Seiji Shioda

Journal of molecular neuroscience : MN　Vol. 59　No. 2　p. 270-9　2016/06　Research paper (scientific journal)

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (vol 7, pg 10594, 2016)

Takanobu Nakazawa, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto, Masahiko Watanabe, Toshiya Manabe, Tadashi Yamamoto, Masatoshi Takeda, Masanobu Kano

NATURE COMMUNICATIONS　Vol. 7　2016/04

[The novel method female encounter test].

Ago Y, Hasebe S, Hashimoto H, Takuma K, Matsuda T

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 147　No. 4　p. 230-234　2016/04

Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder

Ryota Hashimoto, Takanobu Nakazawa, Yoshinori Tsurusaki, Yuka Yasuda, Kazuki Nagayasu, Kensuke Matsumura, Hitoshi Kawashima, Hidenaga Yamamori, Michiko Fujimoto, Kazutaka Ohi, Satomi Umeda-Yano, Masaki Fukunaga, Haruo Fujino, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Masatoshi Takeda, Naomichi Matsumoto, Hitoshi Hashimoto

JOURNAL OF HUMAN GENETICS　Vol. 61　No. 3　p. 199-206　2016/03　Research paper (scientific journal)

Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse

K. Fujiwara, Y. Fujita, A. Kasai, Y. Onaka, H. Hashimoto, H. Okada, T. Yamashita

TRANSLATIONAL PSYCHIATRY　Vol. 6　2016/03　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor.

Zhifang Xu, Hirokazu Ohtaki, Jun Watanabe, Kazuyuki Miyamoto, Norimitsu Murai, Shun Sasaki, Minako Matsumoto, Hitoshi Hashimoto, Yutaka Hiraizumi, Satoshi Numazawa, Seiji Shioda

Scientific reports　Vol. 6　p. 22373-22373　2016/02/29　Research paper (scientific journal)

Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice

Kosuke Higashino, Yukio Ago, Takahiro Umeki, Shigeru Hasebe, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

PSYCHOPHARMACOLOGY　Vol. 233　No. 3　p. 521-528　2016/02　Research paper (scientific journal)

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Takanobu Nakazawa, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto, Masahiko Watanabe, Toshiya Manabe, Tadashi Yamamoto, Masatoshi Takeda, Masanobu Kano

NATURE COMMUNICATIONS　Vol. 7　2016/02　Research paper (scientific journal)

PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks.

Lacaille Helene, Duterte-Boucher Dominique, Vaudry Hubert, Zerdoumi Yasmine, Flaman Jean-Michel, Hashimoto Hitoshi, Vaudry David

Molecular neurobiology　2016

High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

Masanori Nakata, Boyang Zhang, Yifei Yang, Takashi Okada, Norihito Shintani, Hitoshi Hashimoto, Toshihiko Yada

JOURNAL OF DIABETES RESEARCH　2016　Research paper (scientific journal)

De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.

Matsumura Kensuke, Nakazawa Takanobu, Nagayasu Kazuki, Gotoda-Nishimura Nanaka, Kasai Atsushi, Hayata-Takano Atsuko, Shintani Norihito, Yamamori Hidenaga, Yasuda Yuka, Hashimoto Ryota, Hashimoto Hitoshi

Journal of molecular psychiatry　Vol. 4　2016

Structured line illumination Raman microscopy

Kozue Watanabe, Almar F. Palonpon, Nicholas I. Smith, Liang-da Chiu, Atsushi Kasai, Hitoshi Hashimoto, Satoshi Kawata, Katsumasa Fujita

NATURE COMMUNICATIONS　Vol. 6　2015/12　Research paper (scientific journal)

The Female Encounter Test: A Novel Method for Evaluating Reward-Seeking Behavior or Motivation in Mice

Yukio Ago, Shigeru Hasebe, Saki Nishiyama, Satoshi Oka, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　Vol. 18　No. 11　2015/10　Research paper (scientific journal)

Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice

Shigeru Hasebe, Yukio Ago, Saki Nishiyama, Satoshi Oka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

BEHAVIOURAL PHARMACOLOGY　Vol. 26　No. 7　p. 681-690　2015/10　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema

Zsuzsanna Helyes, Jozsef Kun, Nora Dobrosi, Katalin Sandor, Jozsef Nemeth, Aniko Perkecz, Erika Pinter, Krisztina Szabadfi, Balazs Gaszner, Valeria Tekus, Janos Szolcsanyi, Martin Steinhoff, Hitoshi Hashimoto, Dora Reglodi, Tamas Biro

JOURNAL OF INVESTIGATIVE DERMATOLOGY　Vol. 135　No. 9　p. 2209-2218　2015/09　Research paper (scientific journal)

Decreased expression of hippocampal Na+/Ca2+ exchanger isoform-1 by pentylenetetrazole kindling in mice

Takuya Kawanai, Atsuki Taruta, Aya Inoue, Ryo Watanabe, Yukio Ago, Hitoshi Hashimoto, Shigeru Hasebe, Yasuhiro Ooi, Kazuhiro Takuma, Toshio Matsuda

EPILEPSY RESEARCH　Vol. 115　p. 109-112　2015/09　Research paper (scientific journal)

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

Yuta Hara, Kazuhiro Takuma, Erika Takano, Keisuke Katashiba, Atsuki Taruta, Kosuke Higashino, Hitoshi Hashimoto, Yukio Ago, Toshio Matsuda

BEHAVIOURAL BRAIN RESEARCH　Vol. 289　p. 39-47　2015/08　Research paper (scientific journal)

Activation of glycogen metabolism by pituitary adenylate cyclase-activating polypeptide in cultured astrocyte

Kambe, Yuki, Nakashima, Yu, Shintani, Norihito, Hashimoto, Hitoshi, Miyata, Atsuro

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　p. S89-S89　2015/07

Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice

Kazuya Ikeda, Shuhei Tomimoto, Soken Tsuchiya, Ken-Ichi Hamagami, Norihito Shintani, Yukihiko Sugimoto, Atsushi Ichikawa, Atsushi Kasai, Takanobu Nakazawa, Kazuki Nagayasu, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto

Biochemistry and Biophysics Reports　Vol. 2　p. 179-183　2015/07/01　Research paper (scientific journal)

p13 overexpression in pancreatic beta-cells ameliorates type 2 diabetes in high-fat-fed mice

Shintaro Higashi, Kazuhiko Katagi, Norihito Shintani, Kazuya Ikeda, Yukihiko Sugimoto, Soken Tsuchiya, Naoki Inoue, Shota Tanaka, Mai Koumoto, Atsushi Kasai, Takanobu Nakazawa, Atsuko Hayata-Takano, Ken-Ichi Hamagami, Shuhei Tomimoto, Takuya Yoshida, Tadayasu Ohkubo, Kazuki Nagayasu, Yukio Ago, Yusuke Onaka, Ryota Hashimoto, Atsushi Ichikawa, Akemichi Baba, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 461　No. 4　p. 612-617　2015/06　Research paper (scientific journal)

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist

Yukio Ago, Michael C. Condro, Yossan-Var Tan, Cristina A. Ghiani, Christopher S. Colwell, Jesse D. Cushman, Michael S. Fanselow, Hitoshi Hashimoto, James A. Waschek

PSYCHOPHARMACOLOGY　Vol. 232　No. 12　p. 2181-2189　2015/06　Research paper (scientific journal)

ATOMOXETINE REVERSES LOCOMOTOR HYPERACTIVITY, IMPAIRED NOVEL OBJECT RECOGNITION, AND PREPULSE INHIBITION IMPAIRMENT IN MICE LACKING PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE

Y. Shibasaki, A. Hayata-Takano, K. Hazama, T. Nakazawa, N. Shintani, A. Kasai, K. Nagayasu, R. Hashimoto, M. Tanida, T. Katayama, S. Matsuzaki, K. Yamada, M. Taniike, Y. Onaka, Y. Ago, J. A. Waschek, K. Koeves, D. Regloedi, A. Tamas, T. Matsuda, A. Baba, H. Hashimoto

NEUROSCIENCE　Vol. 297　p. 95-104　2015/06　Research paper (scientific journal)

CRTH2, a prostaglandin D-2 receptor, mediates depression-related behavior in mice

Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto

BEHAVIOURAL BRAIN RESEARCH　Vol. 284　p. 131-137　2015/05　Research paper (scientific journal)

Anxiolytic-like effects of restraint during the dark cycle in adolescent mice

Yuki Ota, Yukio Ago, Tatsunori Tanaka, Shigeru Hasebe, Yui Toratani, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

BEHAVIOURAL BRAIN RESEARCH　Vol. 284　p. 103-111　2015/05　Research paper (scientific journal)

Simultaneous neuron- and astrocyte-specific fluorescent marking

Wiebke Schulze, Atsuko Hayata-Takano, Toshihiko Kamo, Takanobu Nakazawa, Kazuki Nagayasu, Atsushi Kasai, Kaoru Seiriki, Norihito Shintani, Yukio Ago, Camille Farfan, Ryota Hashimoto, Akemichi Baba, Hitoshi Hashimoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 459　No. 1　p. 81-86　2015/03　Research paper (scientific journal)

PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF

Katsuya Ogata, Norihito Shintani, Atsuko Hayata-Takano, Toshihiko Kamo, Shintaro Higashi, Kaoru Seiriki, Hisae Momosaki, David Vaudry, Hubert Vaudry, Ludovic Galas, Atsushi Kasai, Kazuki Nagayasu, Takanobu Nakazawa, Ryota Hashimoto, Yukio Ago, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto

PLOS ONE　Vol. 10　No. 3　2015/03　Research paper (scientific journal)

A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

Sergey Malchenko, Simone Treiger Sredni, Hitoshi Hashimoto, Atsushi Kasai, Kazuki Nagayasu, Jianping Xie, Naira V. Margaryan, Kaoru Seiriki, Rishi R. Lulla, Richard E. B. Seftor, Lauren M. Pachman, Herbert Y. Meltzer, Mary J. C. Hendrix, Marcelo B. Soares

PLOS ONE　Vol. 10　No. 3　2015/03　Research paper (scientific journal)

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).

Tomomi Tsumuraya, Hirokazu Ohtaki, Dandan Song, Atsushi Sato, Jun Watanabe, Yutaka Hiraizumi, Tomoya Nakamachi, Zhifang Xu, Kenji Dohi, Hitoshi Hashimoto, Takashi Atsumi, Seiji Shioda

Journal of neuroinflammation　Vol. 12　p. 35-35　2015/02/22　Research paper (scientific journal)

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

Shigeru Hasebe, Naoki Hiramatsu, Yukio Ago, Kazuya Mori, Yuji Watabe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 127　No. 2　p. 232-235　2015/02　Research paper (scientific journal)

Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro

Atsushi Yamasaki, Atsushi Kasai, Akihiro Toi, Maki Kurita, Saki Kimoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Akira Ito, Herbert Y. Meltzer, Yukio Ago, James A. Waschek, Yusuke Onaka, Toshio Matsuda, Akemichi Baba, Hitoshi Hashimoto

JOURNAL OF NEUROCHEMISTRY　Vol. 132　No. 4　p. 418-428　2015/02　Research paper (scientific journal)

Enhancement of the lateral resolution of Raman microscopy by use of structured illumination

Almar F. Palonpon, Kozue Watanabe, Nicholas I. Smith, Liang Da Chiu, Atsushi Kasai, Hitoshi Hashimoto, Satoshi Kawata, Katsumasa Fujita

Optics InfoBase Conference Papers　Vol. Part F132-JSAP 2019　2015　Research paper (international conference proceedings)

Structural and Morphometric Comparison of the Molar Teeth in Pre-eruptive Developmental Stage of PACAP-Deficient and Wild-Type Mice

B. Sandor, K. Fintor, Sz. Felszeghy, T. Juhasz, D. Reglodi, L. Mark, P. Kiss, A. Jungling, B. D. Fulop, A. D. Nagy, H. Hashimoto, R. Zakany, A. Nagy, A. Tamas

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 54　No. 3　p. 331-341　2014/11　Research paper (scientific journal)

Comparative Protein Composition of the Brains of PACAP-Deficient Mice Using Mass Spectrometry-Based Proteomic Analysis

G. Maasz, Z. Pirger, D. Reglodi, D. Petrovics, J. Schmidt, P. Kiss, A. Rivnyak, H. Hashimoto, P. Avar, E. Jambor, A. Tamas, B. Gaszner, L. Mark

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 54　No. 3　p. 310-319　2014/11　Research paper (scientific journal)

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

Kazuhiro Takuma, Yuta Hara, Shunsuke Kataoka, Takuya Kawanai, Yuko Maeda, Ryo Watanabe, Erika Takano, Atsuko Hayata-Takano, Hitoshi Hashimoto, Yukio Ago, Toshio Matsuda

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR　Vol. 126　p. 43-49　2014/11　Research paper (scientific journal)

Characterization of the Thermoregulatory Response to Pituitary Adenylate Cyclase-Activating Polypeptide in Rodents

Eszter Banki, Eszter Pakai, Balazs Gaszner, Csaba Zsiboras, Andras Czett, Paras Rahul Parkash Bhuddi, Hitoshi Hashimoto, Gabor Toth, Andrea Tamas, Dora Reglodi, Andras Garami

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 54　No. 3　p. 543-554　2014/11　Research paper (scientific journal)

Suppression of spinal cord injury on human mesenchymal stem/progenitor cells (MSCs) mediated by pituitary adenylate cyclase activating polypeptide (PACAP)

Ohtaki Hirokazu, Tsumuraya Tomomi, Sato Atsushi, Xu Zhifang, Miyamoto Kazuyuki, Watanabe Jun, Nakamachi Tomoya, Hashimoto Hitoshi, Shioda Seiji

JOURNAL OF NEUROIMMUNOLOGY　Vol. 275　No. 1-2　p. 166-167　2014/10/15

Differential Regulatory Role of Pituitary Adenylate Cyclase-Activating Polypeptide in the Serum-Transfer Arthritis Model

Balint Botz, Kata Bolcskei, Laszlo Kereskai, Miklos Kovacs, Tamas Nemeth, Krisztian Szigeti, Ildiko Horvath, Domokos Mathe, Noemi Kovacs, Hitoshi Hashimoto, Dora Reglodi, Janos Szolcsanyi, Erika Pinter, Attila Mocsai, Zsuzsanna Helyes

ARTHRITIS & RHEUMATOLOGY　Vol. 66　No. 10　p. 2739-2750　2014/10　Research paper (scientific journal)

Behavioral characterization of mice overexpressing human dysbindin-1

Norihito Shintani, Yusuke Onaka, Ryota Hashimoto, Hironori Takamura, Tsuyoshi Nagata, Satomi Umeda-Yano, Akihiro Mouri, Takayoshi Mamiya, Ryota Haba, Shinsuke Matsuzaki, Taiichi Katayama, Hidenaga Yamamori, Takanobu Nakazawa, Kazuki Nagayasu, Yukio Ago, Yuki Yagasaki, Toshitaka Nabeshima, Masatoshi Takeda, Hitoshi Hashimoto

MOLECULAR BRAIN　Vol. 7　2014/10　Research paper (scientific journal)

An enriched environment ameliorates memory impairments in PACAP-deficient mice

Kazuhiro Takuma, Yuko Maeda, Yukio Ago, Toshihiro Ishihama, Kosuke Takemoto, Akira Nakagawa, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

BEHAVIOURAL BRAIN RESEARCH　Vol. 272　p. 269-278　2014/10　Research paper (scientific journal)

Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice

Keisuke Hazama, Atsuko Hayata-Takano, Kazuki Uetsuki, Atsushi Kasai, Naoki Encho, Norihito Shintani, Kazuki Nagayasu, Ryota Hashimoto, Dora Reglodi, Tsuyoshi Miyakawa, Takanobu Nakazawa, Akemichi Baba, Hitoshi Hashimoto

PLOS ONE　Vol. 9　No. 2　2014/02　Research paper (scientific journal)

Central CRTH2, a Second Prostaglandin D-2 Receptor, Mediates Emotional Impairment in the Lipopolysaccharide and Tumor-Induced Sickness Behavior Model

Ryota Haba, Norihito Shintani, Yusuke Onaka, Takuya Kanoh, Hyper Wang, Risa Takenaga, Atsuko Hayata, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Atsushi Kasai, Ryota Hashimoto, Kazuki Nagayasu, Takanobu Nakazawa, Hitoshi Hashimoto, Akemichi Baba

JOURNAL OF NEUROSCIENCE　Vol. 34　No. 7　p. 2514-2523　2014/02　Research paper (scientific journal)

Examination of Calcium-Binding Protein Expression in the Inner Ear of Wild-Type, Heterozygous and Homozygous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Knockout Mice in Kanamycin-Induced Ototoxicity

A. Nemeth, K. Szabadfi, B. Fulop, D. Reglodi, P. Kiss, J. Farkas, B. Szalontai, R. Gabriel, H. Hashimoto, A. Tamas

NEUROTOXICITY RESEARCH　Vol. 25　No. 1　p. 57-67　2014/01　Research paper (scientific journal)

Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner

M. Tanida, A. Hayata, N. Shintani, N. Yamamoto, Y. Kurata, T. Shibamoto, D. A. Morgan, K. Rahmouni, H. Hashimoto

Neuroscience　Vol. 238　p. 297-304　2013/05/05　Research paper (scientific journal)

Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions

Balint Botz, Andras Imreh, Katalin Sandor, Krisztian Elekes, Janos Szolcsanyi, Dora Reglodi, John P. Quinn, James Stewart, Andreas Zimmer, Hitoshi Hashimoto, Zsuzsanna Helyes

PEPTIDES　Vol. 43　p. 105-112　2013/05　Research paper (scientific journal)

Distribution of Secretin Receptors in the Rat Central Nervous System: an in situ Hybridization Study

Zsuzsanna E. Toth, Andrea Heinzlmann, Hitoshi Hashimoto, Katalin Koeves

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 50　No. 1　p. 172-178　2013/05　Research paper (scientific journal)

[Pituitary adenylate cyclase-activating polypeptide(PACAP) plays significant roles in mental function and neuronal development].

Hayata-Takano A, Seiriki K, Tajiri M, Ogata K, Shintani N, Baba A, Hashimoto H

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology　Vol. 33　No. 2　p. 73-75　2013/04

Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice

Yukio Ago, Koji Yano, Ryota Araki, Naoki Hiramatsu, Yuki Kita, Toshiyuki Kawasaki, Hirotaka Onoe, Shigeyuki Chaki, Atsuro Nakazato, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

Neuropharmacology　Vol. 65　p. 29-38　2013/02　Research paper (scientific journal)

Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse

Satoru Arata, Tomoya Nakamachi, Hiroshi Onimaru, Hitoshi Hashimoto, Seiji Shioda

European Journal of Neuroscience　Vol. 37　No. 3　p. 407-416　2013/02　Research paper (scientific journal)

PACAP inhibits β-cell mass expansion in a mouse model of type II diabetes: Persistent suppressive effects on islet density

Hiroaki Inoue, Norihito Shintani, Yusuke Sakurai, Shintaro Higashi, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto

Frontiers in Endocrinology　Vol. 4　2013　Research paper (scientific journal)

The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide

Yukio Ago, Naoki Hiramatsu, Toshihiro Ishihama, Keisuke Hazama, Atsuko Hayata-Takano, Yasuhiro Shibasaki, Norihito Shintani, Hitoshi Hashimoto, Toshiyuki Kawasaki, Hirotaka Onoe, Shigeyuki Chaki, Atsuro Nakazato, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

BEHAVIOURAL PHARMACOLOGY　Vol. 24　No. 1　p. 74-77　2013/01　Research paper (scientific journal)

PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density

Inoue H, Shintani N, Sakurai Y, Higashi S, Hayata-Takano A, Baba A, Hashimoto H

Front Endocrinol (Lausanne)　Vol. 4　2013

Serotonin 5-HT7 Receptor Blockade Reverses Behavioral Abnormalities in PACAP-Deficient Mice and Receptor Activation Promotes Neurite Extension in Primary Embryonic Hippocampal Neurons Therapeutic Implications for Psychiatric Disorders

Minako Tajiri, Atsuko Hayata-Takano, Kaoru Seiriki, Katsuya Ogata, Keisuke Hazama, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 48　No. 3　p. 473-481　2012/11　Research paper (scientific journal)

PACAP is an Endogenous Protective Factor-Insights from PACAP-Deficient Mice

D. Reglodi, P. Kiss, K. Szabadfi, T. Atlasz, R. Gabriel, G. Horvath, P. Szakaly, B. Sandor, A. Lubics, E. Laszlo, J. Farkas, A. Matkovits, R. Brubel, H. Hashimoto, A. Ferencz, A. Vincze, Z. Helyes, L. Welke, A. Lakatos, A. Tamas

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 48　No. 3　p. 482-492　2012/11　Research paper (scientific journal)

Intranasal Application of Secretin, Similarly to Intracerebroventricular Administration, Influences the Motor Behavior of Mice Probably Through Specific Receptors

Andrea Heinzlmann, Gusztav Kiss, Zsuzsanna E. Toth, Roberta Dochnal, Agnes Pal, Ildiko Sipos, Mate Manczinger, Gyula Szabo, Hitoshi Hashimoto, Katalin Koeves

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 48　No. 3　p. 558-564　2012/11　Research paper (scientific journal)

Effects of Pituitary Adenylate Cyclase Activating Polypeptide on Human Sperm Motility

R. Brubel, P. Kiss, A. Vincze, A. Varga, A. Varnagy, J. Bodis, L. Mark, E. Jambor, G. Maasz, H. Hashimoto, Zs. Helyes, G. Toth, A. Tamas, M. Koppan, D. Reglodi

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 48　No. 3　p. 623-630　2012/11　Research paper (scientific journal)

Compensatory Recovery of Blood Glucose Levels in KKA(y) Mice Fed a High-Fat Diet: Insulin-Sparing Effects of PACAP Overexpression in beta Cells

Yusuke Sakurai, Hiroaki Inoue, Norihito Shintani, Akihiro Arimori, Ken-ichi Hamagami, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 48　No. 3　p. 647-653　2012/11　Research paper (scientific journal)

Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with C-11-labeled 20-HETE synthase-specific inhibitor

Toshiyuki Kawasaki, Toshiyuki Marumo, Keiko Shirakami, Tomoko Mori, Hisashi Doi, Masaaki Suzuki, Yasuyoshi Watanabe, Shigeyuki Chaki, Atsuro Nakazato, Yukio Ago, Hitoshi Hashimoto, Toshio Matsuda, Akemichi Baba, Hirotaka Onoe

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　Vol. 32　No. 9　p. 1737-1746　2012/09　Research paper (scientific journal)

A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells

Takeshi Shimada, Yoshihiro Takai, Kikuko Shinohara, Atsushi Yamasaki, Keiko Tominaga-Yoshino, Akihiko Ogura, Akihiro Toi, Kouji Asano, Norihito Shintani, Atsuko Hayata-Takano, Akemichi Baba, Hitoshi Hashimoto

JOURNAL OF NEUROCHEMISTRY　Vol. 122　No. 1　p. 81-93　2012/07　Research paper (scientific journal)

Comparative Examination of Inner Ear in Wild Type and Pituitary Adenylate Cyclase Activating Polypeptide (PACAP)-Deficient Mice

A. Tamas, K. Szabadfi, A. Nemeth, B. Fulop, P. Kiss, T. Atlasz, R. Gabriel, H. Hashimoto, A. Baba, N. Shintani, Zs Helyes, D. Reglodi

NEUROTOXICITY RESEARCH　Vol. 21　No. 4　p. 435-444　2012/05　Research paper (scientific journal)

Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala

Ryota Haba, Norihito Shintani, Yusuke Onaka, Hyper Wang, Risa Takenaga, Atsuko Hayata, Akemichi Baba, Hitoshi Hashimoto

BEHAVIOURAL BRAIN RESEARCH　Vol. 228　No. 2　p. 423-431　2012/03　Research paper (scientific journal)

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MG50028 Reverses Isolation Rearing Induced Abnormal Behaviors in Mice

Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 118　No. 2　p. 295-298　2012/02　Research paper (scientific journal)

THE BEHAVIORAL PHENOTYPE OF PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE-DEFICIENT MICE IN ANXIETY AND DEPRESSION TESTS IS ACCOMPANIED BY BLUNTED c-Fos EXPRESSION IN THE BED NUCLEUS OF THE STRIA TERMINALIS, CENTRAL PROJECTING EDINGER-WESTPHAL NUCLEUS, VENTRAL LATERAL SEPTUM, AND DORSAL RAPHE NUCLEUS

B. Gaszner, V. Kormos, T. Kozicz, H. Hashimoto, D. Reglodi, Z. Helyes

NEUROSCIENCE　Vol. 202　p. 283-299　2012/01　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice

Adrienn Markovics, Viktoria Kormos, Balazs Gaszner, Arvin Lashgarara, Eva Szoke, Katalin Sandor, Krisztina Szabadfi, Bernadett Tuka, Janos Tajti, Janos Szolcsanyi, Erika Pinter, Hitoshi Hashimoto, Jozsef Kun, Dora Reglodi, Zsuzsanna Helyes

NEUROBIOLOGY OF DISEASE　Vol. 45　No. 1　p. 633-644　2012/01　Research paper (scientific journal)

Neuroprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Spinal Cord Injury

Tsuchikawa Daisuke, Nakamachi Tomoya, Tsuchida Masashi, Wada Yoshihiro, Hori Motohide, Farkas Jozsef, Yoshikawa Akira, Kagami Nobuyuki, Imai Nori, Shintani Norihito, Hashimoto Hitoshi, Atsumi Takashi, Shioda Seiji

Journal of Molecular Neuroscience　Vol. 48　No. 3　p. 508-517　2012

Mice Deficient in Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) are More Susceptible to Retinal Ischemic Injury In Vivo

K. Szabadfi, T. Atlasz, P. Kiss, B. Danyadi, A. Tamas, Zs. Helyes, H. Hashimoto, N. Shintani, A. Baba, G. Toth, R. Gabriel, D. Reglodi

NEUROTOXICITY RESEARCH　Vol. 21　No. 1　p. 41-48　2012/01　Research paper (scientific journal)

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice.

Satoko Hattori, Keizo Takao, Koichi Tanda, Keiko Toyama, Norihito Shintani, Akemichi Baba, Hitoshi Hashimoto, Tsuyoshi Miyakawa

Frontiers in behavioral neuroscience　Vol. 6　p. 58-58　2012　Research paper (scientific journal)

Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: Lessons from PACAP-deficient mice

Andras Vincze, Dora Reglodi, Zsuzsanna Helyes, Hitoshi Hashimoto, Norihito Shintani, Hajnalka Abraham

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE　Vol. 29　No. 8　p. 923-935　2011/12　Research paper (scientific journal)

Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission

Yukio Ago, Ryota Araki, Koji Yano, Naoki Hiramatsu, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

PSYCHOPHARMACOLOGY　Vol. 217　No. 3　p. 443-452　2011/10　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: In vivo study with gene-deleted mice

Krisztian Elekes, Katalin Sandor, Andras Moricz, Laszlo Kereskai, Agnes Kemeny, Eva Szoke, Aniko Perkecz, Dora Reglodi, Hitoshi Hashimoto, Erika Pinter, Janos Szolcsanyi, Zsuzsanna Helyes

PEPTIDES　Vol. 32　No. 7　p. 1439-1446　2011/07　Research paper (scientific journal)

PACAP centrally mediates emotional stress-induced corticosterone responses in mice

Naohiro Tsukiyama, Yoko Saida, Michiya Kakuda, Norihito Shintani, Atsuko Hayata, Yoshiko Morita, Mamoru Tanida, Minako Tajiri, Keisuke Hazama, Katsuya Ogata, Hitoshi Hashimoto, Akemichi Baba

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS　Vol. 14　No. 4　p. 368-375　2011/07

The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide

Mamoru Tanida, Norihito Shintani, Hitoshi Hashimoto

NEUROSCIENCE RESEARCH　Vol. 70　No. 1　p. 55-61　2011/05　Research paper (scientific journal)

PACAP is Implicated in the Stress Axes

Hitoshi Hashimoto, Norihito Shintani, Mamoru Tanida, Atsuko Hayata, Ryota Hashimoto, Akemichi Baba

CURRENT PHARMACEUTICAL DESIGN　Vol. 17　No. 10　p. 985-989　2011/04

Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) show increased susceptibility to in vivo renal ischemia/reperfusion injury

Peter Szakaly, Eszter Laszlo, Krisztina Kovacs, Boglarka Racz, Gabriella Horvath, Andrea Ferencz, Andrea Lubics, Peter Kiss, Andrea Tamas, Reka Brubel, Balazs Opper, Akemichi Baba, Hitoshi Hashimoto, Jozsef Farkas, Attila Matkovits, Tamas Magyarlaki, Zsuzsanna Helyes, Dora Reglodi

NEUROPEPTIDES　Vol. 45　No. 2　p. 113-121　2011/04　Research paper (scientific journal)

[Translational research for mental disorder -schizophrenia].

Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Shintani N, Hashimoto H, Baba A, Takeda M

Nippon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 137　No. 2　p. 79-82　2011/02

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice

Toshiyuki Kawasaki, Yukio Ago, Koji Yano, Ryota Araki, Yusuke Washida, Hirotaka Onoe, Shigeyuki Chaki, Atsuro Nakazato, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

NEUROPHARMACOLOGY　Vol. 60　No. 2-3　p. 397-404　2011/02　Research paper (scientific journal)

Trophic Effects of PACAP on Pancreatic Islets: A Mini-Review

Yusuke Sakurai, Norihito Shintani, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 43　No. 1　p. 3-7　2011/01

ROLE OF ENDOGENOUS PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE IN ADULT HIPPOCAMPAL NEUROGENESIS

Y. Ago, M. Yoneyama, T. Ishihama, S. Kataoka, K. Kawada, T. Tanaka, K. Ogita, N. Shintani, H. Hashimoto, A. Baba, K. Takuma, T. Matsuda

NEUROSCIENCE　Vol. 172　p. 554-561　2011/01　Research paper (scientific journal)

Neuroprotective Effect of PACAP Against NMDA-Induced Retinal Damage in the Mouse

Kimi Endo, Tomoya Nakamachi, Tamotsu Seki, Nobuyuki Kagami, Yoshihiro Wada, Keisuke Nakamura, Koji Kishimoto, Motohide Hori, Daisuke Tsuchikawa, Norihito Shinntani, Hitoshi Hashimoto, Akemichi Baba, Ryohei Koide, Seiji Shioda

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 43　No. 1　p. 22-29　2011/01　Research paper (scientific journal)

Cerulein-Induced Acute Pancreatitis in PACAP Knockout Mice

Yusuke Sakurai, Norihito Shintani, Akihiro Arimori, Ken-ichi Hamagami, Naoko Higuchi, Hiroaki Inoue, Kazuya Ikeda, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 43　No. 1　p. 8-15　2011/01　Research paper (scientific journal)

Effect of PACAP on tear secretion in mouse

Nakamachi Tomoya, Aizawa Youichi, Ohtaki Hirokazu, Yofu Sachiko, Seki Tamotsu, Endo Kimi, Nakamura Keisuke, Nobuyuki Kagami, Arata Satoru, Shintani Norihito, Hashimoto Hitoshi, Baba Akemichi, Shioda Seiji

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 42　No. 3　2010/11

Endogenous PACAP attenuated doxorubicin-induced myocardial damage

Mori Hiroyoshi, Nakamachi Tomoya, Ohtaki Hirokazu, Hasegawa Fumio, Yofu Sachiko, Suzuki Hiroshi, Takeyama Youichi, Shintani Norihito, Hashimoto Hitoshi, Baba Akemichi, Shioda Seiji

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 42　No. 3　2010/11

Suppression of oxidative stress by PACAP

Sato Atsushi, Ohtaki Hirokazu, Dohi Kenji, Nakamachi Tomoya, Yofu Sachiko, Ohara Kenji, Hashimoto Hitoshi, Murakami Tomoe, Ando Miki, Shintani Norihito, Baba Akemichi, Shioda Seiji

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 42　No. 3　2010/11

Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor.

Hirokazu Ohtaki, Atsushi Satoh, Tomoya Nakamachi, Sachiko Yofu, Kenji Dohi, Hiroyoshi Mori, Kenji Ohara, Kazuyuki Miyamoto, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Masaji Matsunaga, Seiji Shioda

Journal of molecular neuroscience : MN　Vol. 42　No. 3　p. 397-403　2010/11　Research paper (scientific journal)

Presence of Endogenous PACAP-38 Ameliorated Intestinal Cold Preservation Tissue Injury

Andrea Ferencz, Gyorgy Weber, Zsuzsanna Helyes, Hitoshi Hashimoto, Akemichi Baba, Dora Reglodi

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 42　No. 3　p. 428-434　2010/11　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide Deficiency Enhances Oxazolone-Induced Allergic Contact Dermatitis in Mice

Agnes Kemeny, Dora Reglodi, Renata Cseharovszky, Hitoshi Hashimoto, Akemichi Baba, Janos Szolcsanyi, Erika Pinter, Zsuzsanna Helyes

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 42　No. 3　p. 443-449　2010/11　Research paper (scientific journal)

Intra-Islet PACAP Protects Pancreatic beta-Cells Against Glucotoxicity and Lipotoxicity

Masanori Nakata, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Toshihiko Yada

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 42　No. 3　p. 404-410　2010/11　Research paper (scientific journal)

Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice

K. Sandor, V. Kormos, B. Botz, A. Imreh, K. Boelcskei, B. Gaszner, A. Markovics, J. Szolcsanyi, N. Shintani, H. Hashimoto, A. Baba, D. Reglodi, Zs Helyes

NEUROPEPTIDES　Vol. 44　No. 5　p. 363-371　2010/10　Research paper (scientific journal)

GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: A possible role in the regulation of gonadotropin subunit gene expression

Indri N. Purwana, Haruhiko Kanasaki, Aki Oride, Tselmeg Mijiddorj, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Kohji Miyazaki

PEPTIDES　Vol. 31　No. 9　p. 1748-1755　2010/09　Research paper (scientific journal)

Mice Deficient in Neuropeptide PACAP Demonstrate Increased Sensitivity to In Vitro Kidney Hypoxia

G. Horvath, B. Racz, P. Szakaly, P. Kiss, E. Laszlo, L. Hau, A. Tamas, Z. Helyes, A. Lubics, H. Hashimoto, A. Baba, D. Reglodi

TRANSPLANTATION PROCEEDINGS　Vol. 42　No. 6　p. 2293-2295　2010/07　Research paper (scientific journal)

Comparison of Intestinal Cold Preservation Injury on Pituitary Adenylate Cyclase-Activating Polypeptide in Knockout and Wild-Type Mice

A. Ferencz, K. Nedvig, T. Fekecs, B. Racz, G. Weber, H. Hashimoto, A. Baba, Z. Helyes, D. Regloedi

TRANSPLANTATION PROCEEDINGS　Vol. 42　No. 6　p. 2290-2292　2010/07　Research paper (scientific journal)

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice

Toshihiro Ishihama, Yukio Ago, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

BEHAVIOURAL BRAIN RESEARCH　Vol. 209　No. 2　p. 274-280　2010/06　Research paper (scientific journal)

Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice.

Hiroyoshi Mori, Tomoya Nakamachi, Hirokazu Ohtaki, Sachiko Yofu, Atsushi Sato, Kimi Endo, Yoshitaka Iso, Hiroshi Suzuki, Youichi Takeyama, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Seiji Shioda

Circulation journal : official journal of the Japanese Circulation Society　Vol. 74　No. 6　p. 1183-90　2010/06

15d-Prostaglandin J(2) Enhancement of Nerve Growth Factor-Induced Neurite Outgrowth Is Blocked by the Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells (CRTH2) Antagonist CAY10471 in PC12 Cells

Michiyoshi Hatanaka, Norihiro Shibata, Norihito Shintani, Ryota Haba, Atsuko Hayata, Hitoshi Hashimoto, Akemichi Baba

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 113　No. 1　p. 89-93　2010/05　Research paper (scientific journal)

Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide

Mamoru Tanida, Norihito Shintani, Yoshiko Morita, Naohiro Tsukiyama, Michiyoshi Hatanaka, Hitoshi Hashimoto, Hajime Sawai, Akemichi Baba, Katsuya Nagai

REGULATORY PEPTIDES　Vol. 161　No. 1-3　p. 73-80　2010/04　Research paper (scientific journal)

PACAP-Deficient Mice Exhibit Light Parameter-Dependent Abnormalities on Nonvisual Photoreception and Early Activity Onset

Chihiro Kawaguchi, Yasushi Isojima, Norihito Shintani, Michiyoshi Hatanaka, Xiaohong Guo, Nobuaki Okumura, Katsuya Nagai, Hitoshi Hashimoto, Akemichi Baba

PLOS ONE　Vol. 5　No. 2　2010/02　Research paper (scientific journal)

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

Ryota Hashimoto, Hitoshi Hashimoto, Norihito Shintani, Kazutaka Ohi, Hiroaki Hori, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Nakao Iwata, Norio Ozaki, Kunitoshi Kamijima, Akemichi Baba, Masatoshi Takeda, Hiroshi Kunugi

NEUROSCIENCE LETTERS　Vol. 468　No. 3　p. 300-302　2010/01　Research paper (scientific journal)

Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro

Gabriella Horvath, Laszlo Mark, Reka Brubel, Peter Szakaly, Boglarka Racz, Peter Kiss, Andrea Tamas, Zsuzsanna Helyes, Andrea Lubics, Hitoshi Hashimoto, Akemichi Baba, Norihito Shintani, Gergely Furjes, Jozsef Nemeth, Dora Reglodi

NEUROSCIENCE LETTERS　Vol. 469　No. 1　p. 70-74　2010/01　Research paper (scientific journal)

Increased Stathmin1 Expression in the Dentate Gyrus of Mice Causes Abnormal Axonal Arborizations

Kohei Yamada, Shinsuke Matsuzaki, Tsuyoshi Hattori, Ryusuke Kuwahara, Manabu Taniguchi, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Natsuko Kumamoto, Kazuo Yamada, Takeo Yoshikawa, Taiichi Katayama, Masaya Tohyama

PLOS ONE　Vol. 5　No. 1　2010/01　Research paper (scientific journal)

Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice

Kazuhiro Tanaka, Akiko Kunishige-Yamamoto, Hitoshi Hashimoto, Norihito Shintani, Atsuko Hayata, Akemichi Baba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 391　No. 1　p. 773-777　2010/01　Research paper (scientific journal)

Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain.

Tomoya Nakamachi, Hirokazu Ohtaki, Sachiko Yofu, Kenji Dohi, Jun Watanabe, Hiroyoshi Mori, Atsushi Sato, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Seiji Shioda

Acta neurochirurgica. Supplement　Vol. 106　p. 43-6　2010　Research paper (scientific journal)

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

David Vaudry, Anthony Falluel-Morel, Steve Bourgault, Magali Basille, Delphine Burel, Olivier Wurtz, Alain Fournier, Billy K. C. Chow, Hitoshi Hashimoto, Ludovic Galas, Hubert Vaudry

PHARMACOLOGICAL REVIEWS　Vol. 61　No. 3　p. 283-357　2009/09

Over-Expression of Pancreatic Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Aggravates Cerulein-Induced Acute Pancreatitis in Mice

Ken-ichi Hamagami, Yusuke Sakurai, Norihito Shintani, Naoko Higuchi, Kazuya Ikeda, Hitoshi Hashimoto, Akinobu Suzuki, Hiroshi Kiyama, Akemichi Baba

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 110　No. 4　p. 451-458　2009/08　Research paper (scientific journal)

Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone

Hitoshi Hashimoto, Ryota Hashimoto, Norihito Shintani, Kazuhiro Tanaka, Akiko Yamamoto, Michiyoshi Hatanaka, Xiaohong Guo, Yoshiko Morita, Mamoru Tanida, Katsuya Nagai, Masatoshi Takeda, Akemichi Baba

JOURNAL OF NEUROCHEMISTRY　Vol. 110　No. 2　p. 595-602　2009/07　Research paper (scientific journal)

Inhibitory Effects of Osemozotan, a Serotonin 1A-Receptor Agonist, on Methamphetamine-Induced c-Fos Expression in Prefrontal Cortical Neurons

Rie Tsuchida, Masahiro Kubo, Norihito Shintani, Michikazu Abe, Katalin Koves, Kazuki Uetsuki, Mariko Kuroda, Hitoshi Hashimoto, Akemichi Baba

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 32　No. 4　p. 728-731　2009/04　Research paper (scientific journal)

An Antihyperkinetic Action by the Serotonin 1A-Receptor Agonist Osemozotan Co-administered With Psychostimulants or the Non-stimulant Atomoxetine in Mice

Rie Tsuchida, Masahiro Kubo, Mariko Kuroda, Yasuhiro Shibasaki, Norihito Shintani, Michikazu Abe, Katalin Koves, Hitoshi Hashimoto, Akemichi Baba

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　No. 3　p. 396-402　2009/03　Research paper (scientific journal)

Retardation of retinal vascular development in apelin-deficient mice

Atsushi Kasai, Norihito Shintani, Hideaki Kato, Satoshi Matsuda, Fumi Gomi, Ryota Haba, Hitoshi Hashimoto, Michiya Kakuda, Yasuo Tano, Akemichi Baba

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 28　No. 10　p. 1717-1722　2008/10　Research paper (scientific journal)

Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice

Michiyoshi Hatanaka, Mamoru Tanida, Norihito Shintani, Yasushi Isojima, Chihiro Kawaguchi, Hitoshi Hashimoto, Michiya Kakuda, Ryota Haba, Katsuya Nagai, Akemichi Baba

NEUROSCIENCE LETTERS　Vol. 444　No. 2　p. 153-156　2008/10　Research paper (scientific journal)

Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus

Kiyomi Hagi, Yasu-Taka Azuma, Hidemitsu Nakajima, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Tadayoshi Takeuchi

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 590　No. 1-3　p. 80-86　2008/08　Research paper (scientific journal)

PACAP provides colonic protection against dextran sodium sulfate induced colitis

Yasu-Taka Azuma, Kiycimi Hagi, Norihito Shintani, Mitsuru Kuwamura, Hidemitsu Nakajima, Hitoshi Hashimoto, Akemichi Baba, Tadaycishi Takeuchi

JOURNAL OF CELLULAR PHYSIOLOGY　Vol. 216　No. 1　p. 111-119　2008/07　Research paper (scientific journal)

Markedly reduced white adipose tissue and increased insulin sensitivity in Adcyap1-deficient mice

Shuhei Tomimoto, Tatsuya Qjika, Norihito Shintani, Hitoshi Hashimoto, Ken-ichi Hamagami, Kazuya Ikeda, Masanori Nakata, Toshihiko Yada, Yusuke Sakurai, Takeshi Shimada, Yoshiko Morita, Chie Ishida, Akemichi Baba

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 107　No. 1　p. 41-48　2008/05　Research paper (scientific journal)

PACAP is transiently expressed in anterior pituitary gland of rats: In situ hybridization and cell immunoblot assay studies

Andrea Heinzlmann, Eszter Kirilly, Kinga Meltzer, Eniko Szabo, Akemichi Baba, Hitoshi Hashimoto, Katalin Koeves

PEPTIDES　Vol. 29　No. 4　p. 571-577　2008/04　Research paper (scientific journal)

Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice

Ken Koda, Yukio Ago, Toshiyuki Kawasaki, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

PSYCHOPHARMACOLOGY　Vol. 196　No. 2　p. 293-301　2008/02　Research paper (scientific journal)

Research to develop therapy for ischemic disease from basic research to translational research

Atsushi Kasai, Norihito Shintani, Hideaki Kato, Michiya Kakuda, Fumi Gomi, Yasuo Tano, Hitoshi Hashimoto, Sadaaki Maeda, Akemichi Baba

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 128　p. 45-48　2008　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia

R. Hashimoto, H. Hashimoto, N. Shintani, S. Chiba, S. Hattori, T. Okada, M. Nakajima, K. Tanaka, N. Kawagishi, K. Nemoto, T. Mori, T. Ohnishi, H. Noguchi, H. Hori, T. Suzuki, N. Iwata, N. Ozaki, T. Nakabayashi, O. Saitoh, A. Kosuga, M. Tatsumi, K. Kamijima, D. R. Weinberger, H. Kunugi, A. Baba

MOLECULAR PSYCHIATRY　Vol. 12　No. 11　p. 1026-1032　2007/11　Research paper (scientific journal)

Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice

Yukio Ago, Shigeo Nakamura, Naoko Kajita, Misato Uda, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

SYNAPSE　Vol. 61　No. 9　p. 757-763　2007/09　Research paper (scientific journal)

Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice

Harumi Fujii, Toshihiro Ishihama, Yukio Ago, Norihito Shintani, Michiya Kakuda, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

PEPTIDES　Vol. 28　No. 9　p. 1674-1679　2007/09　Research paper (scientific journal)

Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test

Yukio Ago, Keiko Takahashi, Shigeo Nakamura, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 104　No. 2　p. 153-158　2007/06　Research paper (scientific journal)

A novel DISC1-interacting partner DISC1-binding zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth

T. Hattori, K. Baba, S. Matsuzaki, A. Honda, K. Miyoshi, K. Inoue, M. Taniguchi, H. Hashimoto, N. Shintani, A. Baba, S. Shimizu, F. Yukioka, N. Kumamoto, A. Yamaguchi, M. Tohyama, T. Katayama

MOLECULAR PSYCHIATRY　Vol. 12　No. 4　p. 398-407　2007/04　Research paper (scientific journal)

Galantamine increases the extracellular acetylcholine levels in mouse cerebral cortex.

Ken Koda, Koji Yano, Yukio Ago, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 127　p. 141-143　2007　Research paper (scientific journal)

Neuroprotective mechanism of PACAP associated with IL-6 signaling

Nakamachi Tomoya, Ohtaki Hirokazu, Dohi Kenji, Yofu Sachiko, Hashimoto Hitoshi, Shintani Norihito, Baba Akemichi, Arimura Akira, Shioda Seiji

JOURNAL OF MOLECULAR NEUROSCIENCE　Vol. 33　No. 3　p. 346-347　2007

Modification of cocaine-induced behavioral and neurochemical effects by serotonin(1A) receptor agonist/antagonist in mice

Shigeo Nakamura, Yukio Ago, Aiko Hayashi, Soichi Itoh, Michrya Kakuda, Hitoshi Hashimoto, Akemichi Baba, Toshio Matsuda

SYNAPSE　Vol. 60　No. 7　p. 479-484　2006/12　Research paper (scientific journal)

PACAP suppresses an ischemic neuronal damage mediating in IL-6 signalling

Nakamachi Tomoya, Ohtaki Hirokazu, Dohi Kenji, Yofu Sachiko, Hodoyama Kei, Hashimoto Hitoshi, Shintani Norihito, Baba Akemichi, Arimura Akira, Shioda Seiji

REGULATORY PEPTIDES　Vol. 135　No. 3　2006/08/30

Endogenous PACAP acts as a neuroprotectant against ischemic neuronal damage mediating bcl-2 signal

Nakamachi Tomoya, Ohtaki Hirokazu, Dohi Kenji, Hodoyama Kei, Yofu Sachiko, Hashimoto Hitoshi, Shintani Norihito, Baba Akemichi, Arimura Akira, Shioda Seiji

FRONTIERS IN NEUROENDOCRINOLOGY　Vol. 27　No. 1　2006/05

Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice

K Tanaka, N Shintani, H Hashimoto, N Kawagishi, Y Ago, T Matsuda, R Hashimoto, H Kunugi, A Yamamoto, C Kawaguchi, T Shimada, A Baba

JOURNAL OF NEUROSCIENCE　Vol. 26　No. 19　p. 5091-5097　2006/05　Research paper (scientific journal)

Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adeyap1(-vertical bar-))

Norihito Shintani, Hitoshi Hashimoto, Kazuhiro Tanaka, Naofumi Kawagishi, Chihiro Kawaguchi, Michiyoshi Hatanaka, Yukio Ago, Toshio Matsuda, Akemichi Baba

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY　Vol. 1070　p. 545-549　2006　Research paper (scientific journal)

Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum

M Toyoshima, T Takeuchi, H Goto, K Mukai, N Shintani, H Hashimoto, A Baba, F Hata

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　Vol. 451　No. 4　p. 559-568　2006/01　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6

OHTAKI H, NAKAMACHI T, DOHI K, AIZAWA Y, TAKAKI A, HODOYAMA K, YOFU S, HASHIMOTO H, SHINTANI N, BABA A, KOPF M, IWAKURA Y, MATSUDA K, ARIMURA A, SHIODA S

Proceedings of the National Academy of Sciences of the United States of America　Vol. 103　No. 19　p. 7488-7493　2006

PACAP- and PHI-mediated sustained relaxation in circular muscle of gastric fundus: Findings obtained in PACAP knockout mice

K Mukai, T Takeuchi, M Toyoshima, Y Satoh, A Fujita, N Shintani, H Hashimoto, A Baba, F Hata

REGULATORY PEPTIDES　Vol. 133　No. 1-3　p. 54-61　2006/01　Research paper (scientific journal)

New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice

Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY　Vol. 1070　p. 75-89　2006　Research paper (scientific journal)

Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice

Yoshiko Morita, Daisuke Yanagida, Norihito Shintani, Kiyokazu Ogita, Norito Nishiyama, Rie Tsuchida, Hitoshi Hashimoto, Akemichi Baba

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY　Vol. 1070　p. 450-456　2006　Research paper (scientific journal)

Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells

Megumi Hirose, Hitoshi Hashimoto, Junkko Iga, Norihito Shintani, Megumi Nakanishi, Naohisa Arakawa, Takeshi Shimada, Akemichi Baba

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY　Vol. 1070　p. 342-347　2006　Research paper (scientific journal)

Monoaminergic neuronal development is not affected in PACAP-gene-deficient mice.

Tetsuo Ogawa, Tomoya Nakamachi, Hirokazu Ohtaki, Hitoshi Hashimoto, Shintani N, Akemichi Baba, Jun Watanabe, Sakae Kikuyama, Seiji Shioda

Regulatory peptides　Vol. 126　No. 1-2　p. 103-8　2005/03/15

Neuroprotective action of endogenous PACAP in cultured rat cortical neurons

N Shintani, S Suetake, H Hashimoto, K Koga, A Kasai, C Kawaguchi, Y Morita, M Hirose, Y Sakai, S Tomimoto, T Matsuda, A Baba

REGULATORY PEPTIDES　Vol. 126　No. 1-2　p. 123-128　2005/03　Research paper (scientific journal)

Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells

M Hirose, H Hashimoto, N Shintani, M Nakanishi, N Arakawa, J Iga, H Niwa, J Miyazaki, A Baba

REGULATORY PEPTIDES　Vol. 126　No. 1-2　p. 109-113　2005/03　Research paper (scientific journal)

Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice

K Tanaka, H Hashimoto, N Shintani, A Yamamoto, A Baba

REGULATORY PEPTIDES　Vol. 123　No. 1-3　p. 95-98　2004/12　Research paper (scientific journal)

Overexpression of PACAP in the pancreas failed to rescue early postnatal mortality in PACAP-null mice

N Shintani, H Hashimoto, K Tanaka, C Kawaguchi, S Tomimoto, A Baba

REGULATORY PEPTIDES　Vol. 123　No. 1-3　p. 155-159　2004/12　Research paper (scientific journal)

Apelin is a novel angiogenic factor in retinal endothelial cells

A Kasai, N Shintani, M Oda, M Kakuda, H Hashimoto, T Matsuda, S Hinuma, A Baba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 325　No. 2　p. 395-400　2004/12　Research paper (scientific journal)

PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus

M Nakata, D Kohno, N Shintani, Y Nemoto, H Hashimoto, A Baba, T Yada

NEUROSCIENCE LETTERS　Vol. 370　No. 2-3　p. 252-256　2004/11　Research paper (scientific journal)

PACAPの摂食調節作用

中田 正範, 河野 大輔, 新谷 紀人, 橋本 均, 馬場 明道, 矢田 俊彦

肥満研究　Vol. 10　No. Suppl.　p. 115-115　2004/09

Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain

T Mabuchi, N Shintani, S Matsumura, E Okuda-Ashitaka, H Hashimoto, T Muratani, T Minami, A Baba, S Ito

JOURNAL OF NEUROSCIENCE　Vol. 24　No. 33　p. 7283-7291　2004/08　Research paper (scientific journal)

Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice

S Tomimoto, H Hashimoto, N Shintani, K Yamamoto, Y Kawabata, KI Hamagami, K Yamagata, JI Miyagawa, A Baba

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 309　No. 2　p. 796-803　2004/05　Research paper (scientific journal)

PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells

Y Sakai, H Hashimoto, N Shintani, H Katoh, M Negishi, C Kawaguchi, A Kasai, A Baba

MOLECULAR BRAIN RESEARCH　Vol. 123　No. 1-2　p. 18-26　2004/04　Research paper (scientific journal)

The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation

K Freson, H Hashimoto, C Thys, C Wittevrongel, S Danloy, Y Morita, N Shintani, Y Tomiyama, J Vermylen, MF Hoylaerts, A Baba, C Van Geet

JOURNAL OF CLINICAL INVESTIGATION　Vol. 113　No. 6　p. 905-912　2004/03　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide does not colocalize with vasoactive intestinal polypeptide in the hypothalamic magnocellular nuclei and posterior pituitary of cats and rats

Vereczki, V, K Koves, ZE Toth, A Baba, H Hashimoto, K Fogel, A Arimura, M Kausz

ENDOCRINE　Vol. 22　No. 3　p. 225-237　2003/12　Research paper (scientific journal)

Functional roles of the neuropeptide PACAP in brain and pancreas

N Shintani, S Tomimoto, H Hashimoto, C Kawaguchi, A Baba

LIFE SCIENCES　Vol. 74　No. 2-3　p. 337-343　2003/12　Research paper (scientific journal)

Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes

H Hashimoto, A Kunugi, N Arakawa, N Shintani, T Fujita, A Kasai, C Kawaguchi, Y Morita, M Hirose, Y Sakai, A Baba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 311　No. 2　p. 337-343　2003/11　Research paper (scientific journal)

Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice

S Matsuyama, A Matsumoto, H Hashimoto, N Shintani, A Baba

NEUROREPORT　Vol. 14　No. 16　p. 2095-2098　2003/11　Research paper (scientific journal)

Changes in light-induced phase shift of circadian rhythm in mice lacking PACAP

C Kawaguchi, K Tanaka, Y Isojima, N Shintani, H Hashimoto, A Baba, K Nagai

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 310　No. 1　p. 169-175　2003/10　Research paper (scientific journal)

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes

K Yamamoto, H Hashimoto, S Tomimoto, N Shintani, J Miyazaki, F Tashiro, H Aihara, T Nammo, M Li, K Yamagata, J Miyagawa, Y Matsuzawa, Y Kawabata, Y Fukuyama, K Koga, W Mori, K Tanaka, T Matsuda, A Baba

DIABETES　Vol. 52　No. 5　p. 1155-1162　2003/05　Research paper (scientific journal)

Involvement of intracellular Ca2+ elevation but not cyclic AMP in PACAP-induced p38 MAP kinase activation in PC12 cells

Y Sakai, H Hashimoto, N Shintani, A Ichibori, S Tomimoto, K Tanaka, M Hirose, A Baba

REGULATORY PEPTIDES　Vol. 109　No. 1-3　p. 149-153　2002/11　Research paper (scientific journal)

Defects in reproductive functions in PACAP-deficient female mice

N Shintani, W Mori, H Hashimoto, M Imai, K Tanaka, S Tomimoto, M Hirose, C Kawaguchi, A Baba

REGULATORY PEPTIDES　Vol. 109　No. 1-3　p. 45-48　2002/11　Research paper (scientific journal)

PAC1 receptor-mediated relaxation of longitudinal muscle of the mouse proximal colon

K Mukai, Y Satoh, A Fujita, T Takeuchi, N Shintani, H Hashimoto, A Baba, F Hata

JAPANESE JOURNAL OF PHARMACOLOGY　Vol. 90　No. 1　p. 97-100　2002/09　Research paper (scientific journal)

Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants

H Hashimoto, N Shintani, A Baba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 297　No. 3　p. 427-432　2002/09　Research paper (scientific journal)

Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)

H Hashimoto, N Shintani, K Tanaka, W Mori, M Hirose, T Matsuda, M Sakaue, J Miyazaki, H Niwa, F Tashiro, K Yamamoto, K Koga, S Tomimoto, A Kunugi, S Suetake, A Baba

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 98　No. 23　p. 13355-13360　2001/11　Research paper (scientific journal)

Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells

Y Sakai, H Hashimoto, N Shintani, S Tomimoto, K Tanaka, A Ichibori, M Hirose, A Baba

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 285　No. 3　p. 656-661　2001/07　Research paper (scientific journal)

KB-R7943 inhibits store-operated Ca2+ entry in cultured neurons and astrocytes

N Arakawa, M Sakaue, Yokoyama, I, H Hashimoto, Y Koyama, A Baba, T Matsuda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 279　No. 2　p. 354-357　2000/12　Research paper (scientific journal)

Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type IPACAP (PAC(1)) receptor

N Shintani, H Hashimoto, A Kunugi, Y Koyama, K Yamamoto, S Tomimoto, W Mori, T Matsuda, A Baba

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1509　No. 1-2　p. 195-202　2000/12　Research paper (scientific journal)

Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide

H Hashimoto, N Shintani, A Nishino, M Okabe, M Ikawa, S Matsuyama, K Itoh, K Yamamoto, S Tomimoto, T Fujita, N Hagihara, W Mori, Y Koyama, T Matsuda, S Nagata, A Baba

JOURNAL OF NEUROCHEMISTRY　Vol. 75　No. 5　p. 1810-1817　2000/11　Research paper (scientific journal)

Na+-Ca2+ exchanger isoforms in rat neuronal preparations: different changes in their expression during postnatal development

M Sakaue, H Nakamura, Kaneko, I, Y Kawasaki, N Arakawa, H Hashimoto, Y Koyama, A Baba, T Matsuda

BRAIN RESEARCH　Vol. 881　No. 2　p. 212-216　2000/10　Research paper (scientific journal)

Serum-deprivation induces cell death of rat cultured microglia accompanied with expression of Bax protein

Y Koyama, Y Kimura, Y Yoshioka, D Wakamatsu, RH Kozaki, H Hashimoto, T Matsuda, A Baba

JAPANESE JOURNAL OF PHARMACOLOGY　Vol. 83　No. 4　p. 351-354　2000/08　Research paper (scientific journal)

Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex

M Sakaue, P Somboonthum, B Nishihara, Y Koyama, H Hashimoto, A Baba, T Matsuda

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 129　No. 5　p. 1028-1034　2000/03　Research paper (scientific journal)

L-lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes

Y Koyama, Y Kimura, H Hashimoto, T Matsuda, A Baba

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 59　No. 5　p. 685-691　2000/03　Research paper (scientific journal)

Transient treatments with L-glutamate and threo-beta-hydroxyaspartate induce swelling of rat cultured astrocytes

Y Koyama, T Ishibashi, T Okamoto, T Matsuda, H Hashimoto, A Baba

NEUROCHEMISTRY INTERNATIONAL　Vol. 36　No. 2　p. 167-173　2000/02　Research paper (scientific journal)

Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells

H Hashimoto, N Hagihara, K Koga, K Yamamoto, N Shintani, S Tomimoto, W Mori, Y Koyama, T Matsuda, A Baba

JOURNAL OF NEUROCHEMISTRY　Vol. 74　No. 2　p. 501-507　2000/02　Research paper (scientific journal)

Generation and pharmacological analysis of PAC1 receptor and PACAP knockout mice

Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Toshio Matsucla

Folia Pharmacologica Japonica　Vol. 116　p. 116-120　2000　Research paper (scientific journal)

Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components

Y Koyama, Y Yoshioka, H Hashimoto, T Matsuda, A Baba

NEUROSCIENCE　Vol. 101　No. 1　p. 219-227　2000　Research paper (scientific journal)

Endothelins stimulate expression of cyclooxygenase 2 in rat cultured astrocytes

Y Koyama, T Mizobata, N Yamamoto, H Hashimoto, T Matsuda, A Baba

JOURNAL OF NEUROCHEMISTRY　Vol. 73　No. 3　p. 1004-1011　1999/09　Research paper (scientific journal)

Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1(VPAC(1)) receptor

H Hashimoto, A Nishino, N Shintani, N Hagihara, NG Copeland, NA Jenkins, K Yamamoto, T Matsuda, T Ishihara, S Nagata, A Baba

GENOMICS　Vol. 58　No. 1　p. 90-93　1999/05　Research paper (scientific journal)

Cloning and characterization of the mouse pituitary adenylate cyclase-activating polypeptide (PACAP) gene

K Yamamoto, H Hashimoto, N Hagihara, A Nishino, T Fujita, T Matsuda, A Baba

GENE　Vol. 211　No. 1　p. 63-69　1998/04　Research paper (scientific journal)

Isoform-specific up-regulation by ouabain of Na+,K+-ATPase in cultured rat astrocytes

R Hosoi, T Matsuda, S Asano, H Nakamura, H Hashimoto, K Takuma, A Baba

JOURNAL OF NEUROCHEMISTRY　Vol. 69　No. 5　p. 2189-2196　1997/11　Research paper (scientific journal)

Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor mRNA in the rat adrenal gland: Localization by in situ hybridization and identification of splice variants

H Nogi, H Hashimoto, T Fujita, N Hagihara, T Matsuda, A Baba

JAPANESE JOURNAL OF PHARMACOLOGY　Vol. 75　No. 2　p. 203-207　1997/10　Research paper (scientific journal)

Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation

H Hashimoto, N Ogawa, N Hagihara, K Yamamoto, K Imanishi, H Nogi, A Nishino, T Fujita, T Matsuda, S Nagata, A Baba

MOLECULAR PHARMACOLOGY　Vol. 52　No. 1　p. 128-135　1997/07　Research paper (scientific journal)

Distribution of mRNAs for pituitary adenylate cyclase-activating polypeptide (PACAP), PACAP receptor, vasoactive intestinal polypeptide (VIP), and VIP receptors in the rat superior cervical ganglion

H Nogi, H Hashimoto, N Hagihara, S Shimada, K Yamamoto, T Matsuda, M Tohyama, A Baba

NEUROSCIENCE LETTERS　Vol. 227　No. 1　p. 37-40　1997/05　Research paper (scientific journal)

Role of Na+-Ca2+ exchanger in agonist-induced Ca2+ signaling in cultured rat astrocytes

K Takuma, T Matsuda, H Hashimoto, J Kitanaka, S Asano, Y Kishida, A Baba

JOURNAL OF NEUROCHEMISTRY　Vol. 67　No. 5　p. 1840-1845　1996/11　Research paper (scientific journal)

Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: An in situ hybridization study

H Hashimoto, H Nogi, K Mori, H Ohishi, R Shigemoto, K Yamamoto, T Matsuda, N Mizuno, S Nagata, A Baba

JOURNAL OF COMPARATIVE NEUROLOGY　Vol. 371　No. 4　p. 567-577　1996/08　Research paper (scientific journal)

cDNA cloning of a mouse pituitary adenylate cyclase-activating polypeptide receptor

H Hashimoto, K Yamamoto, N Hagihara, N Ogawa, A Nishino, H Aino, H Nogi, K Imanishi, T Matsuda, A Baba

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1281　No. 2　p. 129-133　1996/06　Research paper (scientific journal)

Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes

T Matsuda, K Takuma, E Nishiguchi, S Asano, H Hashimoto, J Azuma, A Baba

EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 8　No. 5　p. 951-958　1996/05　Research paper (scientific journal)

Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures

J Kitanaka, H Hashimoto, M Gotoh, K Kondo, K Sakata, Y Hirasawa, M Sawada, A Suzumura, T Marunouchi, T Matsuda, A Baba

BRAIN RESEARCH　Vol. 707　No. 2　p. 282-287　1996/01　Research paper (scientific journal)

Effect of taurine on angiotensin II-induced expression of immediate early response genes in primary cultured neonatal rat heart cells

Takahashi K, Hashimoto H, Baba A, Schaffer S. W, Azuma J

Adv Exp Med Biol　Vol. 403　p. 297-304　1996

STRUCTURE OF THE GENE ENCODING THE MOUSE PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE RECEPTOR

H AINO, H HASHIMOTO, N OGAWA, A NISHINO, K YAMAMOTO, H NOGI, S NAGATA, A BABA

GENE　Vol. 164　No. 2　p. 301-304　1995/10　Research paper (scientific journal)

STIMULATION OF CYCLIC-AMP FORMATION BY PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE IS ATTENUATED BY GLUTAMATE IN RAT-BRAIN SLICES

K KONDO, H HASHIMOTO, K SAKATA, H SAGA, J KITANAKA, A BABA

JAPANESE JOURNAL OF PHARMACOLOGY　Vol. 67　No. 4　p. 399-401　1995/04

EXPRESSION OF GLUTAMATE TRANSPORTERS IN CULTURED GLIAL-CELLS

K KONDO, H HASHIMOTO, J KITANAKA, M SAWADA, A SUZUMURA, T MARUNOUCHI, A BABA

NEUROSCIENCE LETTERS　Vol. 188　No. 2　p. 140-142　1995/03　Research paper (scientific journal)

CDNA CLONING OF A THROMBOXANE A(2) RECEPTOR FROM RAT ASTROCYTES

J KITANAKA, H HASHIMOTO, Y SUGIMOTO, M SAWADA, M NEGISHI, A SUZUMURA, T MARUNOUCHI, A ICHIKAWA, A BABA

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH　Vol. 1265　No. 2-3　p. 220-223　1995/03

CONSTITUTIVE ACTIVATION OF THE FAS LIGAND GENE IN MOUSE LYMPHOPROLIFERATIVE DISORDERS

D WATANABE, T SUDA, H HASHIMOTO, S NAGATA

EMBO JOURNAL　Vol. 14　No. 1　p. 12-18　1995/01　Research paper (scientific journal)

TUNICAMYCIN INHIBITS PROSTAGLANDIN-F2-ALPHA RECEPTOR-MEDIATED PHOSPHOINOSITIDE HYDROLYSIS IN CULTURED RAT ASTROCYTES

J KITANAKA, T HAMANO, M GOTOH, H HASHIMOTO, A BABA

NEUROCHEMICAL RESEARCH　Vol. 19　No. 12　p. 1545-1550　1994/12　Research paper (scientific journal)

CULTURED RAT ASTROCYTES POSSESS NA+-CA2+ EXCHANGER

K TAKUMA, T MATSUDA, H HASHIMOTO, S ASANO, A BABA

GLIA　Vol. 12　No. 4　p. 336-342　1994/12　Research paper (scientific journal)

CLONING AND EXPRESSION OF A CDNA FOR RAT PROSTAGLANDIN-F2-ALPHA RECEPTOR

J KITANAKA, H HASIMOTO, Y SUGIMOTO, M NEGISHI, H AINO, M GOTOH, A ICHIKAWA, A BABA

PROSTAGLANDINS　Vol. 48　No. 1　p. 31-41　1994/07　Research paper (scientific journal)

IDENTIFICATION AND CHARACTERIZATION OF PARATHYROID-HORMONE PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR IN CULTURED ASTROCYTES

H HASHIMOTO, H AINO, N OGAWA, S NAGATA, A BABA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 200　No. 2　p. 1042-1048　1994/04　Research paper (scientific journal)

MOLECULAR-CLONING AND TISSUE DISTRIBUTION OF A RECEPTOR FOR PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE

H HASHIMOTO, T ISHIHARA, R SHIGEMOTO, K MORI, S NAGATA

NEURON　Vol. 11　No. 2　p. 333-342　1993/08　Research paper (scientific journal)

INHIBITORY GLUTAMATE RESPONSE ON CYCLIC-AMP FORMATION IN CULTURED ASTROCYTES

A BABA, H SAGA, H HASHIMOTO

NEUROSCIENCE LETTERS　Vol. 149　No. 2　p. 182-184　1993/01　Research paper (scientific journal)

MECHANISM OF EXTRACELLULAR ATP-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN RAT GLIOMA C(6) CELLS

J KITANAKA, H HASHIMOTO, M GOTOH, T MAYUMI, A BABA

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 263　No. 3　p. 1248-1252　1992/12　Research paper (scientific journal)

IDENTIFICATION OF THE PROSTACYCLIN RECEPTOR BY USE OF [15-3H1]19-(3-AZIDOPHENYL)-20-NORISOCARBACYCLIN, AN IRREVERSIBLE SPECIFIC PHOTOAFFINITY PROBE

S ITO, H HASHIMOTO, M NEGISHI, M SUZUKI, H KOYANO, R NOYORI, A ICHIKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 267　No. 28　p. 20326-20330　1992/10　Research paper (scientific journal)

AN AZIDO-FUNCTIONALIZED ISOCARBACYCLIN ANALOG ACTING AS AN EFFICIENT PHOTOAFFINITY PROBE FOR A PROSTACYCLIN RECEPTOR

M SUZUKI, H KOYANO, R NOYORI, H HASHIMOTO, M NEGISHI, A ICHIKAWA, S ITO

TETRAHEDRON　Vol. 48　No. 13　p. 2635-2658　1992/03　Research paper (scientific journal)

TRANSLOCATION OF ALPHA-SUBUNITS OF STIMULATORY GUANINE NUCLEOTIDE-BINDING PROTEINS THROUGH STIMULATION OF THE PROSTACYCLIN RECEPTOR IN MOUSE MASTOCYTOMA-CELLS

M NEGISHI, H HASHIMOTO, A ICHIKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 267　No. 4　p. 2364-2369　1992/02　Research paper (scientific journal)

PROSTAGLANDIN-E1 RECEPTOR FROM MOUSE MASTOCYTOMA P-815 CELLS COUPLES TO 60-KDA GTP-BINDING PROTEIN

H HASHIMOTO, R OGINO, H SAEKI, K YATSUNAMI, A ICHIKAWA

BIOCHIMICA ET BIOPHYSICA ACTA　Vol. 1095　No. 2　p. 140-144　1991/10　Research paper (scientific journal)

TEI-9063, A STABLE AND HIGHLY SPECIFIC PROSTACYCLIN ANALOG FOR THE PROSTACYCLIN RECEPTOR IN MASTOCYTOMA P-815 CELLS

M NEGISHI, H HASHIMOTO, K YATSUNAMI, S KUROZUMI, A ICHIKAWA

PROSTAGLANDINS　Vol. 42　No. 3　p. 225-237　1991/09　Research paper (scientific journal)

DIFFERENTIAL REGULATION OF THROMBIN-INDUCED OR ATP-INDUCED MOBILIZATION OF INTRACELLULAR CA2+ BY PROSTACYCLIN RECEPTOR IN MOUSE MASTOCYTOMA-CELLS

M NEGISHI, H HASHIMOTO, A ICHIKAWA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 176　No. 1　p. 102-107　1991/04　Research paper (scientific journal)

IDENTIFICATION OF A PROSTACYCLIN RECEPTOR COUPLED TO THE ADENYLATE-CYCLASE SYSTEM VIA A STIMULATORY GTP-BINDING PROTEIN IN MOUSE MASTOCYTOMA P-815 CELLS

H HASHIMOTO, M NEGISHI, A ICHIKAWA

PROSTAGLANDINS　Vol. 40　No. 5　p. 491-505　1990/11　Research paper (scientific journal)

EFFECT OF TUNICAMYCIN ON FUNCTIONS OF PGE1 RECEPTORS FROM MOUSE MASTOCYTOMA P-815 CELLS

K YATSUNAMI, J FUJISAWA, H HASHIMOTO, K KIMURA, S TAKAHASHI, A ICHIKAWA

BIOCHIMICA ET BIOPHYSICA ACTA　Vol. 1051　No. 1　p. 94-99　1990/01　Research paper (scientific journal)

2006 Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases neuronal cell death after focal ischemia associated with interlerukin-6 (IL-6).

Ohtaki H, Nakamachi T, Aizawa Y, Dohi K, Hodoyama K, Yofu S, Takaki A, Hashimoto H, Shintani N, Baba A, Kopf M, Iwakura Y, Arimura A, Shioda S

Proc Natl Acad Sci　No. 103　p. 7486-7493

2016 PACAP suppresses dry eye symptoms through stimulation of tear production.

Nakamachi T, Aizawa Y, Ohtaki H, Yofu S, Seki T, Endo K, Wada Y, Kagami N, Dohi K, Arata S, Hashimoto H, Shintani N, Baba A, Mark L, Kiss P, Farkas J, Reglodi D, Shioda S

Nature Commun