The dipicolylamino group as an efficient leaving group for amide bond formation via hexafluoroisopropyl ester

Yasuhito Akai, Yuya Asahina, Hironobu Hojo

Organic and Biomolecular Chemistry　Vol. 22　No. 8　p. 1699-1707　2024　Research paper (scientific journal)

Differentiation of isobaric cross‐linked peptides prepared via maleimide chemistry using MALDI‐MS and MS/MS

Luis Javier González, Satomy Pousa, Hironobu Hojo, Shio Watanabe, Daisuke Higo, Alina Rodriguez Mallon, Toshifumi Takao

Rapid Communications in Mass Spectrometry　Vol. 38　No. 2　2023/11/22　Research paper (scientific journal)

Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity

Kenta Arai, Masaki Okumura, Young-Ho Lee, Hidekazu Katayama, Kenji Mizutani, Yuxi Lin, Sam-Yong Park, Kaichiro Sawada, Masao Toyoda, Hironobu Hojo, Kenji Inaba, Michio Iwaoka

Communications Chemistry　Vol. 6　No. 1　2023/11/21　Research paper (scientific journal)

Structure Elucidation of Olanzapine Molecular Salts by Combining Mechanochemistry and Micro-Electron Diffraction

Diptajyoti Gogoi, Toshiyuki Sasaki, Takanori Nakane, Akihiro Kawamoto, Hironobu Hojo, Genji Kurisu, Ranjit Thakuria

Crystal Growth and Design　Vol. 23　No. 8　p. 5821-5826　2023/06/27　Research paper (scientific journal)

Dynamics of the HP1 Hinge Region with DNA Measured by Site-Directed Spin Labeling-EPR Spectroscopy

Isao Suetake, Kazunobu Sato, Tomoaki Sugishita, Yuichi Mishima, Toshiki Takei, Toshimichi Fujiwara, Risa Mutoh, Akira Shinohara, Takeji Takui, Makoto Miyata, Hironobu Hojo, Toshiaki Arata

Applied Magnetic Resonance　Vol. 54　No. 1　p. 119-141　2023/01/05　Research paper (scientific journal)

Chemical synthesis of per-selenocysteine human epidermal growth factor.

Toshiki Takei, Hideaki Tanaka, Nobuaki Okumura, Toshifumi Takao, Luis Moroder, Hironobu Hojo

Journal of peptide science : an official publication of the European Peptide Society　2022/12/02　Research paper (scientific journal)

Lipid chain-driven interaction of a lipidated Src-family kinase Lyn with the bilayer membrane.

Shinya Hanashima, Kanako Mito, Yuichi Umegawa, Michio Murata, Hironobu Hojo

Organic & biomolecular chemistry　Vol. 20　No. 32　p. 6436-6444　2022/08/17　Research paper (scientific journal)

Toward the Chemical Syntheses of Fucosylated Peptides: A Combination of Protecting Groups for the Hydroxy Groups of Fucose

Yuya Asahina, Tatsuya Ando, Hironobu Hojo

Bulletin of the Chemical Society of Japan　Vol. 95　No. 8　p. 1196-1208　2022/08/15　Research paper (scientific journal)

Structural and spectroscopic characterization of CO inhibition of [NiFe]-hydrogenase from Citrobacter sp. S-77

Takahiro Imanishi, Koji Nishikawa, Midori Taketa, Katsuhiro Higuchi, Hulin Tai, Shun Hirota, Hironobu Hojo, Toru Kawakami, Kiriko Hataguchi, Kayoko Matsumoto, Hideaki Ogata, Yoshiki Higuchi

Acta Crystallographica Section F: Structural Biology Communications　Vol. 78　p. 66-74　2022/02/01　Research paper (scientific journal)

Relative configuration of Cys-Pro ester peptides in thioester formation

Toru Kawakami, Eri Sasakura, Yohei Miyanoiri, Hironobu Hojo

Journal of Peptide Science　2022　Research paper (scientific journal)

Investigation of protecting group for sialic acid carboxy moiety toward sialylglycopeptide synthesis by the TFA-labile protection strategy

Shun Ito, Yuya Asahina, Hironobu Hojo

Tetrahedron　Vol. 97　p. 132423-132423　2021/09　Research paper (scientific journal)

FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers

Mikito Nakano, Shinya Hanashima, Toshiaki Hara, Kazuya Kabayama, Yuya Asahina, Hironobu Hojo, Naoko Komura, Hiromune Ando, Thomas K.M. Nyholm, J. Peter Slotte, Michio Murata

Biochimica et Biophysica Acta (BBA) - Biomembranes　Vol. 1863　No. 8　p. 183623-183623　2021/08　Research paper (scientific journal)

Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy

Isao Suetake, Shigeaki Nakazawa, Kazunobu Sato, Risa Mutoh, Yuichi Mishima, Toru Kawakami, Toshiki Takei, Mikio Watanabe, Norio Sakai, Toshimichi Fujiwara, Takeji Takui, Makoto Miyata, Akira Shinohara, Hironobu Hojo, Toshiaki Arata

Biochemical and Biophysical Research Communications　Vol. 567　p. 42-48　2021/08　Research paper (scientific journal)

Total Synthesis and Structural Characterization of Caveolin‐1

Hironobu Hojo, Toshiki Takei, Yuya Asahina, Nobuaki Okumura, Toshifumi Takao, Masatomo So, Isao Suetake, Takeshi Sato, Akihiro Kawamoto, Yoshio Hirabayashi

Angewandte Chemie International Edition　Vol. 60　No. 25　p. 13900-13905　2021/06/14　Research paper (scientific journal)

Chemical synthesis of palmitoylated histone H4

Hironobu Hojo, Isao Suetake

Arkivoc　Vol. 2021　No. 4　2020/11/18　Research paper (scientific journal)

スピンラベルESRによるヘテロクロマチンタンパク質HP1の天然変性構造の動的研究 ヒンジDNA結合とN末端リン酸化

荒田 敏昭, 佐藤 和信, 平居 永名, 武藤 梨沙, 三島 優一, 工位 武治, 川上 徹, 北條 裕信, 藤原 敏道, 宮田 真人, 末武 勲

日本生化学会大会プログラム・講演要旨集　Vol. 93回　p. [P-468]　2020/09

Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant

Elliot J. Crooks, Brandon A. Irizarry, Martine Ziliox, Toru Kawakami, Tiffany Victor, Feng Xu, Hironobu Hojo, Kelley Chiu, Carlos Simmerling, William E. Van Nostrand, Steven O. Smith, Lisa M. Miller

Journal of Biological Chemistry　Vol. 295　No. 27　p. 8914-8927　2020/07/03　Research paper (scientific journal)

Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.

Atsuya Nishiyama, Christopher B Mulholland, Sebastian Bultmann, Satomi Kori, Akinori Endo, Yasushi Saeki, Weihua Qin, Carina Trummer, Yoshie Chiba, Haruka Yokoyama, Soichiro Kumamoto, Toru Kawakami, Hironobu Hojo, Genta Nagae, Hiroyuki Aburatani, Keiji Tanaka, Kyohei Arita, Heinrich Leonhardt, Makoto Nakanishi

Nature communications　Vol. 11　No. 1　p. 1222-1222　2020/03/06　Research paper (scientific journal)

Modern Peptide and Protein Chemistry: Reaching New Heights

Christian P. R. Hackenberger, Philip E. Dawson, Yong-Xiang Chen, Hironobu Hojo

The Journal of Organic Chemistry　Vol. 85　No. 3　p. 1328-1330　2020/02/07　Research paper (scientific journal)

One Step Synthesis of Fmoc-Aminoacyl-N-alkylcysteine via the Ugi Four-Component Condensation Reaction

Yuya Asahina, Hironobu Hojo

The Journal of Organic Chemistry　2020/02/07　Research paper (scientific journal)

Chemical synthesis of ferredoxin with 4 selenocysteine residues using a segment condensation method

Toshiki Takei, Tomoshige Ando, Toshifumi Takao, Yusuke Ohnishi, Genji Kurisu, Michio Iwaoka, Hironobu Hojo

Chemical Communications　Vol. 56　No. 91　p. 14239-14242　2020　Research paper (scientific journal)

Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.

Yuichi Mishima, Laura Brueckner, Saori Takahashi, Toru Kawakami, Junji Otani, Akira Shinohara, Kohei Takeshita, Ronald Garingalao Garvilles, Mikio Watanabe, Norio Sakai, Hideyuki Takeshima, Charlotte Nachtegael, Atsuya Nishiyama, Makoto Nakanishi, Kyohei Arita, Kinichi Nakashima, Hironobu Hojo, Isao Suetake

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 25　No. 1　p. 22-32　2020/01　Research paper (scientific journal)

On-resin synthesis of cyclic peptides via tandem N-to-S acyl migration and intramolecular thiol additive-free native chemical ligation

Gloria Serra, Laura Posadaa, Hironobu Hojo

Chem. Commun.　2019/12　Research paper (scientific journal)

スピンラベルESRによるヘテロクロマチンタンパク質HP1の動的構造の研究 アイソフォーム特異性とリン酸化

荒田 敏昭, 中澤 重顕, 三島 優一, 佐藤 和信, 工位 武治, 川上 徹, 北條 裕信, 藤原 敏道, 宮田 真人, 末武 勲

日本生化学会大会プログラム・講演要旨集　Vol. 92回　p. [2T13m-02]　2019/09

Chemical synthesis of the ubiquitinated form of histone H3 and its effect on DNA methyltransferase 1

Toru Kawakami, Yuichi Mishima, Masaya Takazawa, Hironobu Hojo, Isao Suetake

Journal of Peptide Science　Vol. 25　No. 9　2019/09　Research paper (scientific journal)

酸性糖脂質とインスリン受容体の膜貫通ペプチドの静電的相互作用の解析(Analysis of electrostatic interaction of acidic glycolipid with transmembrane peptide of insulin receptor)

Nimura Yuka, Kabayama Kazuya, Asahina Yuya, Hanashima Shinya, Hojo Hironobu, Murata Michio, Fukase Koichi

生物物理　Vol. 59　No. Suppl.1-2　p. S411-S411　2019/08

Glycopeptide Synthesis Based on a TFA-Labile Protection Strategy and One-Pot Four-Segment Ligation for the Synthesis of O-Glycosylated Histone H2A

Yuya Asahina, Toru Kawakami, Hironobu Hojo

European Journal of Organic Chemistry　Vol. 2019　No. 9　p. 1915-1920　2019/03　Research paper (scientific journal)

ライゲーション法によるタンパク質，糖タンパク質の化学合成 有機合成を利用した(糖)タンパク質研究を目指して

北條裕信

化学と生物　Vol. 57　No. 1　p. 58-63　2019/01

Revalidation of recombinant aequorin as a light emission standard: Estimation of specific activity of Gaussia luciferase

S. Inouye, H. Hojo

Biochem. Biophys. Res. Commun.　Vol. 507　p. 242-245　2018/11　Research paper (scientific journal)

Use of selenoester for the efficient synthesis of protein

Takei Toshiki, Iwaoka Michio, Hojo Hironobu

JOURNAL OF PEPTIDE SCIENCE　Vol. 24　p. S72-S72　2018/09

Synthesis of selenocysteine-containing cyclic peptides via tandem N-to-S acyl migration and intramolecular selenocysteine-mediated native chemical ligation

Shingo Shimodaira, Toshiki Takei, Hironobu Hojo, Michio Iwaoka

Chemical Communications　Vol. 54　No. 83　p. 11737-11740　2018/09　Research paper (scientific journal)

Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization

Masahiro Noji, Masatomo So, Keiichi Yamaguchi, Hironobu Hojo, Maki Onda, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yuji Goto

Biochemistry　Vol. 57　No. 37　p. 5415-5426　2018/08　Research paper (scientific journal)

セレンを利用したタンパク質合成の新展開 - セレノシステイン, セレノエステルのタンパク質科学への応用

武居俊樹, 北條裕信

化学　Vol. 73　No. 5　p. 68-69　2018/05

Characterization and optimization of two-chain folding pathways of insulin via native chain assembly

Kenta Arai, Toshiki Takei, Reina Shinozaki, Masato Noguchi, Shouta Fujisawa, Hidekazu Katayama, Luis Moroder, Setsuko Ando, Masaki Okumura, Kenji Inaba, Hironobu Hojo, Michio Iwaoka

COMMUNICATIONS CHEMISTRY　Vol. 1　No. 26　2018/05　Research paper (scientific journal)

Sialyl Tn Unit with TFA-Labile Protection Realizes Efficient Synthesis of Sialyl Glycoprotein

Naoki Takeda, Toshiki Takei, Yuya Asahina, Hironobu Hojo

Chemistry - A European Journal　Vol. 24　No. 11　p. 2593-2597　2018/02/21　Research paper (scientific journal)

One-Pot Four-Segment Ligation Using Seleno- and Thioesters: Synthesis of Superoxide Dismutase

Toshiki Takei, Tomoshige Andoh, Toshifumi Takao, Hironobu Hojo

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 56　No. 49　p. 15708-15711　2017/12　Research paper (scientific journal)

Development of SAAP3D force field and the application to replica-exchange Monte Carlo simulation for chignolin and C-peptide

Michio Iwaoka, Toshiki Suzuki, Yuya Shoji, Kenichi Dedachi, Taku Shimosato, Toshiya Minezaki, Hironobu Hojo, Hiroyuki Onuki, Hiroshi Hirota

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN　Vol. 31　No. 12　p. 1039-1052　2017/12　Research paper (scientific journal)

Air N-protection free ligation of the peptide thioester and the peptide with an N-alkoxy- or N-aryloxyamino group at its N-terminus

Hironobu Hojo, Toru Kawakami, Yuta Hiroyama, Saburo Aimoto

TETRAHEDRON LETTERS　Vol. 58　No. 49　p. 4638-4641　2017/12　Research paper (scientific journal)

Structureof the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

Satoshi Ishiyama, Atsuya Nishiyama, Yasushi Saeki, Kei Moritsugu, Daichi Morimoto, Luna Yamaguchi, Naoko Arai, Rumie Matsumura, Toru Kawakami, Yuichi Mishima, Hironobu Hojo, Shintaro Shimamura, Fuyuki Ishikawa, Shoji Tajima, Keiji Tanaka, Mariko Ariyoshi, Masahiro Shirakawa, Mitsunori Ikeguchi, Akinori Kidera, Isao Suetake, Kyohei Arita, Makoto Nakanishi

MOLECULAR CELL　Vol. 68　No. 2　p. 350-+　2017/10　Research paper (scientific journal)

RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails

Yuichi Mishima, Laura Brueckner, Saori Takahashi, Toru Kawakami, Kyohei Arita, Shota Oka, Junji Otani, Hironobu Hojo, Masahiro Shirakawa, Akira Shinohara, Mikio Watanabe, Isao Suetake

FEBS JOURNAL　Vol. 284　No. 20　p. 3455-3469　2017/10　Research paper (scientific journal)

Regulation of CCR7-dependent cell migration through CCR7 homodimer formation

Daichi Kobayashi, Masataka Endo, Hirotaka Ochi, Hironobu Hojo, Masayuki Miyasaka, Haruko Hayasaka

SCIENTIFIC REPORTS　Vol. 7　2017/08　Research paper (scientific journal)

Total Synthesis and Antibacterial Investigation of Plusbacin A(3)

Akira Katsuyama, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Toru Kawakami, Hironobu Hojo, Fumika Yakushiji, Satoshi Ichikawa

ORGANIC LETTERS　Vol. 19　No. 14　p. 3771-3774　2017/07　Research paper (scientific journal)

Synthesis of ubiquitylated histone H3 using a thiirane linker for chemical ligation

Toru Kawakami, Yuichi Mishima, Hironobu Hojo, Isao Suetake

JOURNAL OF PEPTIDE SCIENCE　Vol. 23　No. 7-8　p. 532-538　2017/07　Research paper (scientific journal)

Preparation of Selenoinsulin as a Long‐Lasting Insulin Analogue

Kenta Arai, Toshiki Takei, Masaki Okumura, Satoshi Watanabe, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo, Kenji Inaba, Michio Iwaoka

Angewandte Chemie　Vol. 129　No. 20　p. 5614-5618　2017/05/08　Research paper (scientific journal)

Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue

Kenta Arai, Toshiki Takei, Masaki Okumura, Satoshi Watanabe, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo, Kenji Inaba, Michio Iwaoka

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 56　No. 20　p. 5522-5526　2017/05　Research paper (scientific journal)

Pyrrole-Based Macrocyclic Small-Molecule Inhibitors That Target Oocyte Maturation

Pethaiah Gunasekaran, So-Rim Lee, Seung-Min Jeong, Jeong-Woo Kwon, Toshiki Takei, Yuya Asahina, Geul Bang, Seongnyeon Kim, Mija Ahn, Eun Kyung Ryu, Hak Nam Kim, Ki-Yub Nam, Song Yub Shin, Hironobu Hojo, Suk Namgoong, Nam-Hyung Kim, Jeong Kyu Bang

CHEMMEDCHEM　Vol. 12　No. 8　p. 580-589　2017/04　Research paper (scientific journal)

Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions

Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita, Hiroyuki Saito

Peptide Science 2016　p. 141-142　2017/02/26　Research paper (bulletin of university, research institution)

One-pot native chemical ligation by combination of two orthogonal thioester precursors

Yuya Asahina, Toru Kawakami, Hironobu Hojo

CHEMICAL COMMUNICATIONS　Vol. 53　No. 13　p. 2114-2117　2017/02　Research paper (scientific journal)

Variation of Free-Energy Landscape of the p53 C-Terminal Domain Induced by Acetylation: Enhanced Conformational Sampling

Shinji Iida, Tadaaki Mashimo, Takashi Kurosawa, Hironobu Hojo, Hiroya Muta, Yuji Goto, Yoshifumi Fukunishi, Haruki Nakamura, Junichi Higo

JOURNAL OF COMPUTATIONAL CHEMISTRY　Vol. 37　No. 31　p. 2687-2700　2016/12　Research paper (scientific journal)

Toward the Understanding of Glycoprotein through Chemical Synthesis

Hironobu Hojo

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN　Vol. 74　No. 10　p. 984-992　2016/10　Research paper (scientific journal)

Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides

Yuki Takechi-Haraya, Ryo Nadai, Hitoshi Kimura, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Kohsaku Kawakami, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita, Hiroyuki Saito

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1858　No. 6　p. 1339-1349　2016/06　Research paper (scientific journal)

A strategy for the synthesis of hydrophobic proteins and glycoproteins

Hironobu Hojo

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 14　No. 27　p. 6368-6374　2016　Research paper (scientific journal)

Nucleosome compaction facilitates HP1 gamma binding to methylated H3K9

Yuichi Mishima, Chanika D. Jayasinghe, Kai Lu, Junji Otani, Masahiro Shirakawa, Toru Kawakami, Hironobu Kimura, Hironobu Hojo, Peter Carlton, Shoji Tajima, Isao Suetake

NUCLEIC ACIDS RESEARCH　Vol. 43　No. 21　p. 10200-10212　2015/12　Research paper (scientific journal)

The effects of chemically synthesized saposin C on glucosylceramide-beta-glucosidase

Azusa Yoneshige, Masanaga Muto, Takashi Watanabe, Hironobu Hojo, Junko Matsuda

CLINICAL BIOCHEMISTRY　Vol. 48　No. 16-17　p. 1177-1180　2015/11　Research paper (scientific journal)

Synthesis of histone proteins by CPE ligation using a recombinant peptide as the C-terminal building block

Toru Kawakami, Ryo Yoshikawa, Yuki Fujiyoshi, Yuichi Mishima, Hironobu Hojo, Shoji Tajima, Isao Suetake

JOURNAL OF BIOCHEMISTRY　Vol. 158　No. 5　p. 403-411　2015/11　Research paper (scientific journal)

Site-specific labeling of synthetic peptide using the chemoselective reaction between N-methoxyamino acid and isothiocyanate

Toshiaki Hara, Euis Maras Purwati, Akira Tainosyo, Toru Kawakami, Hironobu Hojo, Saburo Aimoto

JOURNAL OF PEPTIDE SCIENCE　Vol. 21　No. 10　p. 765-769　2015/10　Research paper (scientific journal)

Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy

Yuya Asahina, Shinobu Komiya, Ami Ohagi, Rina Fujimoto, Hiroko Tamagaki, Katsuhiro Nakagawa, Takashi Sato, Shizuo Akira, Toshifumi Takao, Akira Ishii, Yoshiaki Nakahara, Hironobu Hojo

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 54　No. 28　p. 8226-8230　2015/07　Research paper (scientific journal)

Peptidyl N-alkylcysteine as a peptide thioester surrogate in the native chemical ligation

Yuya Asahina, Kei Nabeshima, Hironobu Hojo

Tetrahedron Letters　Vol. 56　No. 11　p. 1370-1373　2015/03　Research paper (scientific journal)

Trifluoroethanol-containing RP-HPLC mobile phases for the separation of transmembrane peptides human glycophorin-A, integrin alpha-1, and p24: analysis and prevention of potential side reactions due to formic acid

Toshiaki Hara, Yue Huang, Akihiro Ito, Toru Kawakami, Hironobu Hojo, Michio Murata

JOURNAL OF PEPTIDE SCIENCE　Vol. 21　No. 2　p. 61-70　2015/02　Research paper (scientific journal)

Synthesis of Fmoc-Thr Unit Carrying Core 1O-Linked Sugar With Acid-SensitiveO-Protecting Group and Its Application to the Synthesis of Glycosylated Peptide Thioester

Yuya Asahina, Rina Fujimoto, Akemi Suzuki, Hironobu Hojo

Journal of Carbohydrate Chemistry　Vol. 34　No. 1　p. 12-27　2015/01/02　Research paper (scientific journal)

3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides

Akihiro Taguchi, Kentarou Fukumoto, Yuya Asahina, Akihiro Kajiyama, Shunsuke Shimura, Keisuke Hamada, Kentaro Takayama, Fumika Yakushiji, Hironobu Hojo, Yoshio Hayashi

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 13　No. 11　p. 3186-3189　2015　Research paper (scientific journal)

Direct evidence for the function of crustacean insulin-like androgenic gland factor (IAG): Total chemical synthesis of IAG

Hidekazu Katayama, Nozomi Kubota, Hironobu Hojo, Ayumi Okada, Sayaka Kotaka, Naoaki Tsutsui, Tsuyoshi Ohira

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 22　No. 21　p. 5783-5789　2014/11　Research paper (scientific journal)

Coupling of Transmembrane Helix Orientation To Membrane Release of the Juxtamembrane Region in FGFR3

Hiroko Tamagaki, Yusuke Furukawa, Ritsuko Yamaguchi, Hironobu Hojo, Saburo Aimoto, Steven O. Smith, Takeshi Sato

BIOCHEMISTRY　Vol. 53　No. 30　p. 5000-5007　2014/08　Research paper (scientific journal)

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

Suk-Youl Park, Jung-Eun Park, Tae-Sung Kim, Ju Hee Kim, Mi-Jeong Kwak, Bonsu Ku, Lan Tian, Ravichandran N. Murugan, Mija Ahn, Shinobu Komiya, Hironobu Hojo, Nam-Hyung Kim, Bo Yeon Kim, Jeong K. Bang, Raymond L. Erikson, Ki Won Lee, Seung Jun Kim, Byung-Ha Oh, Wei Yang, Kyung S. Lee

NATURE STRUCTURAL & MOLECULAR BIOLOGY　Vol. 21　No. 8　p. 696-703　2014/08　Research paper (scientific journal)

Recent progress in the chemical synthesis of proteins

H. Hojo

Curr Opin Struct Biol.　2014/05　Research paper (scientific journal)

Model Study Using Designed Selenopeptides on the Importance of the Catalytic Triad for the Antioxidative Functions of Glutathione Peroxidase

Toshiki Takei, Yoshiko Urabe, Yuya Asahina, Hironobu Hojo, Takeshi Nomura, Kenichi Dedachi, Kenta Arai, Michio Iwaoka

JOURNAL OF PHYSICAL CHEMISTRY B　Vol. 118　No. 2　p. 492-500　2014/01　Research paper (scientific journal)

A novel post-ligation thioesterification device enables peptide ligation in the N to C direction: synthetic study of human glycodelin

Takaomi Takenouchi, Hidekazu Katayama, Yuko Nakahara, Yoshiaki Nakahara, Hironobu Hojo

JOURNAL OF PEPTIDE SCIENCE　Vol. 20　No. 1　p. 55-61　2014/01　Research paper (scientific journal)

Fast preparation of an N-acetylglucosaminylated peptide segment for the chemoenzymatic synthesis of a glycoprotein

Yuya Asahina, Mika Kanda, Akemi Suzuki, Hidekazu Katayama, Yoshiaki Nakahara, Hironobu Hojo

Organic and Biomolecular Chemistry　Vol. 11　No. 41　p. 7199-7207　2013/11/07　Research paper (scientific journal)

Chemoenzymatic Synthesis of the Immunoglobulin Domain of Tim-3 Carrying a Complex-Type N-Glycan by Using a One-pot Ligation

Yuya Asahina, Shigehiro Kamitori, Toshifumi Takao, Nozomu Nishi, Hironobu Hojo

Angewandte Chemie International Edition　Vol. 52　No. 37　p. 9733-9737　2013/09/09　Research paper (scientific journal)

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity

Akihiro Wada, Pooi-Fong Wong, Hironobu Hojo, Makoto Hasegawa, Akitoyo Ichinose, Rafael Llanes, Yoshinao Kubo, Masachika Senba, Yoshio Ichinose

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 434　No. 2　p. 223-227　2013/05　Research paper (scientific journal)

The phenacyl group as an efficient thiol protecting group in a peptide condensation reaction by the thioester method

Hidekazu Katayama, Hironobu Hojo

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 11　No. 26　p. 4405-4413　2013　Research paper (scientific journal)

Chemoenzymatic Synthesis of Hydrophobic Glycoprotein: Synthesis of Saposin C Carrying Complex-Type Carbohydrate

Hironobu Hojo, Hiromasa Tanaka, Masashi Hagiwara, Yuya Asahina, Akiharu Ueki, Hidekazu Katayama, Yuko Nakahara, Azusa Yoneshige, Junko Matsuda, Yukishige Ito, Yoshiaki Nakaharat

JOURNAL OF ORGANIC CHEMISTRY　Vol. 77　No. 21　p. 9437-9446　2012/11　Research paper (scientific journal)

Pyrrolysine Analogs as Substrates for Bacterial Pyrrolysyl-tRNA Synthetase in Vitro and in Vivo

Hidekazu Katayama, Kayo Nozawa, Osamu Nureki, Yoshiaki Nakahara, Hironobu Hojo

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　Vol. 76　No. 1　p. 205-208　2012/01　Research paper (scientific journal)

Chemical synthesis of the S-linked glycopeptide, sublancin

Hidekazu Katayama, Yuya Asahina, Hironobu Hojo

Journal of Peptide Science　Vol. 17　No. 12　p. 818-821　2011/12　Research paper (scientific journal)

Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide

Youhei Sohma, Hitomi Kitamura, Hiroyuki Kawashima, Hironobu Hojo, Masayuki Yamashita, Kenichi Akaji, Yoshiaki Kiso

TETRAHEDRON LETTERS　Vol. 52　No. 52　p. 7146-7148　2011/12　Research paper (scientific journal)

グルコシルセラミド-β-グルコシダーゼ活性に対する化学合成サポシンCの影響

米重 あづさ, 田野 千春, 北條 裕信, 松田 純子

日本生化学会大会プログラム・講演要旨集　Vol. 84回　p. 2P-0022　2011/09

Synthesis of biantennary complex-type nonasaccharyl asn building blocks for solid-phase glycopeptide synthesis

Masashi Hagiwara, Mizuki Dohi, Yuko Nakahara, Keiko Komatsu, Yuya Asahina, Akiharu Ueki, Hironobu Hojo, Yoshiaki Nakahara, Yukishige Ito

Journal of Organic Chemistry　Vol. 76　No. 13　p. 5229-5239　2011/07/01　Research paper (scientific journal)

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts

Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P. Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki, Kazuki Nabeshima

BMC CANCER　Vol. 11　2011/07　Research paper (scientific journal)

Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element

Hironobu Hojo, Hidekazu Katayama, Chiharu Tano, Yuko Nakahara, Azusa Yoneshige, Junko Matsuda, Youhei Sohma, Yoshiaki Kiso, Yoshiaki Nakahara

TETRAHEDRON LETTERS　Vol. 52　No. 5　p. 635-639　2011/02　Research paper (scientific journal)

Efficient preparation of Fmoc-aminoacyl-N-ethylcysteine unit, a key device for the synthesis of peptide thioesters

Hironobu Hojo, Hajime Kobayashi, Risa Ubagai, Yuya Asahina, Yuko Nakahara, Hidekazu Katayama, Yukishige Ito, Yoshiaki Nakahara

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 9　No. 19　p. 6807-6813　2011　Research paper (scientific journal)

N-Methyl-phenacyloxycarbamidomethyl (Pocam) group: a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions

Hidekazu Katayama, Yoshiaki Nakahara, Hironobu Hojo

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 9　No. 12　p. 4653-4661　2011　Research paper (scientific journal)

Antioxidative Glutathione Peroxidase Activity of Selenoglutathione

Sari Yoshida, Fumio Kumakura, Itsuki Komatsu, Kenta Arai, Yuko Onuma, Hironobu Hojo, Beena G. Singh, K. Indira Priyadarsini, Michio Iwaoka

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 50　No. 9　p. 2125-2128　2011　Research paper (scientific journal)

Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity

Akihiro Wada, Makoto Hasegawa, Pooi-Fong Wong, Emi Shirai, Nobuaki Shirai, Li-Jing Tan, Rafael Llanes, Hironobu Hojo, Eiki Yamasaki, Akitoyo Ichinose, Yoshio Ichinose, Masachika Senba

GLYCOBIOLOGY　Vol. 20　No. 6　p. 668-678　2010/06　Research paper (scientific journal)

Correct Disulfide Pairing Is Required for the Biological Activity of Crustacean Androgenic Gland Hormone (AGH): Synthetic Studies of AGH

Hidekazu Katayama, Hironobu Hojo, Tsuyoshi Ohira, Akira Ishii, Takamichi Nozaki, Kiyomi Goto, Yuko Nakahara, Tetsuo Takahashi, Yuriko Hasegawa, Hiromichi Nagasawa, Yoshiaki Nakahara

BIOCHEMISTRY　Vol. 49　No. 8　p. 1798-1807　2010/03　Research paper (scientific journal)

Solid-phase synthesis of glycopeptide carrying a tetra-N-acetyllactosamine-containing core 2 decasaccharide

Akiharu Ueki, Yutaka Takano, Akiko Kobayashi, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON　Vol. 66　No. 9　p. 1742-1759　2010/02　Research paper (scientific journal)

Progress in the Ligation Chemistry for Glycoprotein Synthesis

Hironobu Hojo, Hidekazu Katayama, Yoshiaki Nakahara

Trends in Glycoscience and Glycotechnology　Vol. 22　No. 128　p. 269-279　2010　Research paper (scientific journal)

Chemical synthesis of mouse pro-opiomelanocortin(1-74) by azido-protected glycopeptide ligation via the thioester method

Hidekazu Katayama, Hironobu Hojo, Ichiko Shimizu, Yuko Nakahara, Yoshiaki Nakahara

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 8　No. 8　p. 1966-1972　2010　Research paper (scientific journal)

The Mercaptomethyl Group Facilitates an Efficient One-Pot Ligation at Xaa-Ser/Thr for (Glyco)peptide Synthesis

Hironobu Hojo, Chinatsu Ozawa, Hidekazu Katayama, Akiharu Ueki, Yuko Nakahara, Yoshiaki Nakahara

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 49　No. 31　p. 5318-5321　2010　Research paper (scientific journal)

High-pressure-promoted Fmoc-aminoacylation of N-ethylcysteine: preparation of key devices for the solid-phase synthesis of peptide thioesters

Yuko Nakahara, Ichiro Matsuo, Yukishige Ito, Risa Ubagai, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON LETTERS　Vol. 51　No. 2　p. 407-410　2010/01　Research paper (scientific journal)

Definitive evidence that a single N-glycan among three glycans on inducible costimulator is required for proper protein trafficking and ligand binding

Naoki Kamei, Rie Fukui, Yoshiyuki Suzuki, Yasuhiro Kajihara, Mitsuhiro Kinoshita, Kazuaki Kakehi, Hironobu Hojo, Katsunari Tezuka, Takashi Tsuji

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 391　No. 1　p. 557-563　2010/01　Research paper (scientific journal)

Solid-phase synthesis of O-sulfated glycopeptide by the benzyl-protected glycan strategy

Keita Kawahira, Hiromasa Tanaka, Akiharu Ueki, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON　Vol. 65　No. 39　p. 8143-8153　2009/09　Research paper (scientific journal)

Pyruvoyl, a novel amino protecting group on the solid phase peptide synthesis and the peptide condensation reaction

Hidekazu Katayama, Takumi Utsumi, Chinatsu Ozawa, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON LETTERS　Vol. 50　No. 7　p. 818-821　2009/02　Research paper (scientific journal)

A Novel Method for the Preparation of Peptide Thioester and its Application to Glycoprotein Synthesis

Hironobu Hojo, Yuko Onuma, Yuri Akimoto, Yuko Nakahara, Yoshiaki Nakahara

PEPTIDES FOR YOUTH　Vol. 611　p. 129-130　2009　Research paper (scientific journal)

Efficient sequential segment coupling using N-alkylcysteine-assisted thioesterification for glycopeptide dendrimer synthesis

Chinatsu Ozawa, Hidekazu Katayama, Hironobu Hojo, Yuko Nakahara, Yoshiaki Nakahara

ORGANIC LETTERS　Vol. 10　No. 16　p. 3531-3533　2008/08　Research paper (scientific journal)

An efficient peptide ligation using azido-protected peptides via the thioester method.

H. Katayama, H. Hojo, T. Ohira, Y. Nakahara

Tetrahedron Lett.　2008/07　Research paper (scientific journal)

Stereoselective synthesis of benzyl-protected beta-galactosides by propionitrile-mediated glycosylation

Akiharu Ueki, Masafumi Hirota, Yuta Kobayashi, Keiko Komatsu, Yutaka Takano, Michio Iwaoka, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON　Vol. 64　No. 11　p. 2611-2618　2008/03　Research paper (scientific journal)

Application of a novel thioesterification reaction to the synthesis of chemokine CCL27 by the modified thioester method

Hironobu Hojo, Yuichi Murasawa, Hidekazu Katayama, Tsuyoshi Ohira, Yuko Nakaharaa, Yoshiaki Nakahara

ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 6　No. 10　p. 1808-1813　2008　Research paper (scientific journal)

Synthesis of glycopeptide dendrimer by a convergent method

Chinatsu Ozawa, Hironobu Hojo, Yuko Nakahara, Hidekazu Katayama, Kazuki Nabeshima, Toshiaki Akahane, Yoshiaki Nakahara

TETRAHEDRON　Vol. 63　No. 39　p. 9685-9690　2007/09　Research paper (scientific journal)

Purification and substrate specificity of UDP-D-xylose :beta-D-glucoside alpha-1,3-D-xylosyltransferase involved in the biosynthesis of the Xyl alpha 1-3Xyl alpha 1-3Glc beta 1-O-Ser on epidermal growth factor-like domains

Takeshi Ishimizu, Kyoko Sano, Takashi Uchida, Hiroshi Teshima, Kaoru Omichi, Hironobu Hojo, Yoshiaki Nakahara, Sumihiro Hase

JOURNAL OF BIOCHEMISTRY　Vol. 141　No. 4　p. 593-600　2007/04　Research paper (scientific journal)

Solid-phase synthesis of core 3 and core 6 O-glycan-linked glycopeptides by benzyl-protection method

Yuko Nakahara, Chinatsu Ozawa, Eriko Tanaka, Kazuki Ohtsuka, Yutaka Takano, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON　Vol. 63　No. 10　p. 2161-2169　2007/03　Research paper (scientific journal)

Synthesis of biantennary LacNAc-linked O-glycan (core 4) and glycopeptide thioester by benzyl protection strategy: rapid zinc reduction of GlcNTCA to GlcNAc by microwave irradiation

Akiharu Ueki, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara

TETRAHEDRON　Vol. 63　No. 10　p. 2170-2181　2007/03　Research paper (scientific journal)

Recent progress in the field of glycopeptide synthesis

Hironobu Hojo, Yoshiaki Nakahara

BIOPOLYMERS　Vol. 88　No. 2　p. 308-324　2007　Research paper (scientific journal)

Peptide Thioester Synthesis via an Auxiliary-Mediated N – S Acyl Shift Reaction in Solution.

K. Nakamura, H. Mori, T. Kawakami, H. Hojo, Y. Nakahara, S. Aimoto

Int. J. Pept. Res. Ther.　2007/01　Research paper (scientific journal)

N-alkyl cysteine-assisted thioesterification of peptides

Hironobu Hojo, Yuko Onuma, Yuri Akimoto, Yuko Nakahara, Yoshiaki Nakahara

TETRAHEDRON LETTERS　Vol. 48　No. 1　p. 25-28　2007/01　Research paper (scientific journal)

Chemoenzymatic synthesis of a MUC1 glycopeptide carrying non-natural sialyl TF-beta O-glycan

Eriko Tanaka, Yuko Nakahara, Yasuhiro Kuroda, Yutaka Takano, Naoya Kojima, Hironobu Hojo, Yoshiaki Nakahara

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　Vol. 70　No. 10　p. 2515-2522　2006/10　Research paper (scientific journal)

Efficient microwave-assisted tandem N- to S-acyl transfer and thioester exchange for the preparation of a glycosylated peptide thioester

Fumihiro Nagaike, Yuko Onuma, Chie Kanazawa, Hironobu Hojo, Akiharu Ueki, Yuko Nakahara, Yoshiaki Nakahara

ORGANIC LETTERS　Vol. 8　No. 20　p. 4465-4468　2006/09　Research paper (scientific journal)

Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression

K Nabeshima, H Iwasaki, K Koga, H Hojo, J Suzumiya, M Kikuchi

PATHOLOGY INTERNATIONAL　Vol. 56　No. 7　p. 359-367　2006/07　Research paper (scientific journal)

Synthesis of a glycosylated peptide thioester by the Boc strategy and its application to segment condensation

Eiichiro Haginoya, Hironobu Hojo, Yuko Nakahara, Yoshiaki Nakahara, Kazuki Nabeshima, Bryan P. Toole, Yasushi Watanabe

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　Vol. 70　No. 6　p. 1338-1349　2006/06　Research paper (scientific journal)

2P488 Evaluation of the SAAP simulation program by use of Metenkephalin and C-peptide(51. New methods and tools (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Ooka Ryuta, Hojo Hironobu, Nakahara Yoshiaki, Kimura Naoki, Habiro Norikazu, Yosida Daisuke, Iwaoka Michio

Seibutsu Butsuri　Vol. 46　No. 2　2006

Chemical synthesis of MUC2 tandem repeat model carrying multiple O-GalNAc moieties

Hironobu Hojo, Yoshiyuki Matsumoto, Yoshiaki Nakahara, Yusuke Suzuki, Minoru Suzuki, Akemi Suzuki

UNDERSTANDING BIOLOGY USING PEPTIDES　p. 309-+　2006　Research paper (international conference proceedings)

Chemical synthesis of 23 kDa glycoprotein by repetitive segment condensation: A synthesis of MUC2 basal motif carrying multiple O-GaINAc moieties

H Hojo, Y Matsumoto, Y Nakahara, E Ito, Y Suzuki, M Suzuki, A Suzuki, Y Nakahara

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 127　No. 39　p. 13720-13725　2005/10　Research paper (scientific journal)

Solid-phase synthesis of core 8 O-glycan-linked MUC5AC glycopeptide

Makoto Maemura, Atsushi Ohgaki, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara

Bioscience, Biotechnology and Biochemistry　Vol. 69　No. 8　p. 1575-1583　2005/08/23　Research paper (scientific journal)

Synthesis and biological activity of the extracellular Ig domain of emmprin carrying various carbohydrate chains

Hironobu Hojo, Eiichiro Haginoya, Yoshiyuki Matsumoto, Yoshiaki Nakahara, Kazuki Nabeshima, Bryan P. Toole, Yasushi Watanabe

Peptides 2004, Proceedings　p. 587-588　2005　Research paper (international conference proceedings)

Synthesis of a mimic for the heterogeneous surface of core 2 sialoglycan-linked glycoprotein

Y Takano, H Hojo, N Kojima, Y Nakahara

ORGANIC LETTERS　Vol. 6　No. 18　p. 3135-3138　2004/09　Research paper (scientific journal)

Synthesis and conformational characterization of the epidermal growth factor-like domain of blood coagulation factor IX carrying xylosyl-glucose

M Kitamura, H Hojo, Y Nakahara, T Ishimizu, S Hase

GLYCOCONJUGATE JOURNAL　Vol. 21　No. 5　p. 197-203　2004　Research paper (scientific journal)

Solid-phase synthesis of core 2 O-linked glycopeptide and its enzymatic sialylation

Y Takano, N Kojima, Y Nakahara, H Hojo, Y Nakahara

TETRAHEDRON　Vol. 59　No. 42　p. 8415-8427　2003/10　Research paper (scientific journal)

Studies directed toward the synthesis of protein-bound GPI anchor

Y Tanaka, Y Nakahara, H Hojo, Y Nakahara

TETRAHEDRON　Vol. 59　No. 23　p. 4059-4067　2003/06　Research paper (scientific journal)

Enhanced cell adhesion on RGDS-carrying keratin film

K Yamauchi, H Hojo, Y Yamamoto, T Tanabe

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS　Vol. 23　No. 4　p. 467-472　2003/06　Research paper (scientific journal)

Synthesis of an unnatural N-glycan-linked dolichyl pyrophosphate precursor

Yuko Nakahara, Tomoharu Nonaka, Hironobu Hojo, Yoshiaki Nakahara

Bioscience, Biotechnology and Biochemistry　Vol. 67　No. 8　p. 1761-1766　2003/01/01　Research paper (scientific journal)

Preparation of core 2 type tetrasaccharide carrying decapeptide by benzyl protection-based solid-phase synthesis strategy

Yutaka Takano, Motoki Habiro, Masaomi Someya, Hironobu Hojo, Yoshiaki Nakahara

Tetrahedron Letters　Vol. 43　No. 46　p. 8395-8399　2002/11/11　Research paper (scientific journal)

Three-dimensional structure of the S4-S5 segment of the Shaker potassium channel

O Ohlenschlager, H Hojo, R Ramachandran, M Gorlach, PI Haris

BIOPHYSICAL JOURNAL　Vol. 82　No. 6　p. 2995-3002　2002/06　Research paper (scientific journal)

Synthesis of mucin-type glycopeptide (β hCG 130-145) by on-resin fragment condensation of the glycopeptide segments carrying unmasked oligosaccharides

Tsuyoshi Ichiyanagi, Maki Takatani, Kimitoshi Sakamoto, Yuko Nakahara, Yukishige Ito, Hironobu Hojo, Yoshiaki Nakahara

Tetrahedron Letters　Vol. 43　No. 18　p. 3297-3300　2002/04/29　Research paper (scientific journal)

Synthesis of Core-class 2 O-Linked Glycopeptides: A Benzyl-protected Tetrasaccharyl Serine and its Derivative Carrying a Hydrophobic Cholestanyl Group

Jun Watabe, Latika Singh, Yuko Nakahara, Yukishige Ito, Hironobu Hojo, Yoshiaki Nakahara

Bioscience, Biotechnology and Biochemistry　Vol. 66　No. 9　p. 1904-1914　2002/01/01　Research paper (scientific journal)

Silyl linker-based approach to the solid-phase synthesis of fmoc glycopeptide thioesters

Akira Ishii, Hironobu Hojo, Yuko Nakahara, Yukishige Ito

Bioscience, Biotechnology and Biochemistry　Vol. 66　No. 2　p. 225-232　2002　Research paper (scientific journal)

Salmonella enteritidis FliC (Flagella Filament Protein) Induces Human β-Defensin-2 mRNA Production by Caco-2 Cells

Ken-Ichi Ogushi, Akihiro Wada, Takuro Niidome, Naoki Mori, Kazunori Oishi, Tsuyoshi Nagatake, Akira Takahashi, Hiroshi Asakura, Sou-Ichi Makino, Hironobu Hojo, Yoshiaki Nakahara, Mio Ohsaki, Tomomitsu Hatakeyama, Haruhiko Aoyagi, Hisao Kurazono, Joel Moss, Toshiya Hirayama

Journal of Biological Chemistry　Vol. 276　No. 32　p. 30521-30526　2001/08/10　Research paper (scientific journal)

New allyl ester linker and solid-phase block synthesis of the serglycin core region

Yuko Nakahara, Sumie Ando, Ito Yukishige, Hironobu Hojo, Yoshiaki Nakahara

Bioscience, Biotechnology and Biochemistry　Vol. 65　No. 6　p. 1358-1368　2001/06　Research paper (scientific journal)

Synthesis of the extracellular Ig domain I of Emmprin carrying a chitobiose unit

Hironobu Hojo, Jun Watabe, Yoshiaki Nakahara, Yuko Nakahara, Yukishige Ito, Kazuki Nabeshima, Bryan P. Toole

Tetrahedron Letters　Vol. 42　No. 16　p. 3001-3004　2001/04/16　Research paper (scientific journal)

Expression of human β-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: Antibacterial effect of hBD-2 against Helicobacter pylori

Y. Hamanaka, M. Nakashima, A. Wada, M. Ito, H. Kurazono, H. Hojo, Y. Nakahara, S. Kohno, T. Hirayama, I. Sekine

Gut　Vol. 49　No. 4　p. 481-487　2001　Research paper (scientific journal)

Helicobacter pylori-mediated transcriptional regulation of the human β-defensin 2 gene requires NF-κB

Akihiro Wada, Ken-Ichi Ogushi, Takahiro Kimura, Hironobu Hojo, Naoki Mori, Shoichi Suzuki, Atsushi Kumatori, May Se, Yoshiaki Nakahara, Michio Nakamura, Joel Moss, Toshiya Hirayama

Cellular Microbiology　Vol. 3　No. 2　p. 115-123　2001　Research paper (scientific journal)

Conformational characterization of designed minibarnase

Ken-Ichi Takahashi, Tosiyuki Noguti, Hironobu Hojo, Tadayasu Ohkubo, Mitiko go

Biopolymers　Vol. 58　No. 3　p. 260-267　2001　Research paper (scientific journal)

A facile silyl linker strategy for the solid-phase synthesis of protected glycopeptide: Synthesis of an N-terminal fragment of IL-2 (1-10)

Akira Ishii, Hironobu Hojo, Aki Kobayashi, Kazuhiko Nakamura, Yuko Nakahara, Yukishige Ito, Yoshiaki Nakahara

Tetrahedron　Vol. 56　No. 34　p. 6235-6243　2000/08/18　Research paper (scientific journal)

Solid-phase synthesis of serglycin glycopeptides on a new allyl ester linker

Yuko Nakahara, Sumie Ando, Masaki Itakura, Naomi Kumabe, Hironobu Hojo, Yukishige Ito, Yoshiaki Nakahara

Tetrahedron Letters　Vol. 41　No. 33　p. 6489-6493　2000/08/12　Research paper (scientific journal)

Recent Progress in the Solid-phase Synthesis of Glucopeptide

Hironobu Hojo, Yoshiaki Nakahara

Current Protein and Peptide Science　Vol. 1　No. 1　p. 23-48　2000　Research paper (scientific journal)

Induction of human β-defensin-2 mRNA expression by Helicobacter pylori in human gastric cell line MKN45 cells on cag Pathogenicity Island

Akihiro Wada, Naoki Mori, Kazunori Oishi, Hironobu Hojo, Yoshiaki Nakahara, Yoichi Hamanaka, Masahiro Nagashima, Ichiro Sekine, Ken-Ichi Ogushi, Takuro Niidome, Tsuyoshi Nagatake, Joel Moss, Toshiya Hirayama

Biochemical and Biophysical Research Communications　Vol. 263　No. 3　p. 770-774　1999/10/05　Research paper (scientific journal)

A mini-protein designed by removing a module from barnase: molecular modeling and NMR measurements of the conformation

Ken-ichi Takahashi, Tosiyuki Noguti, Hironobu Hojo, Kiyoshi Yamauchi, Masayoshi Kinoshita, Saburo Aimoto, Tadayasu Ohkubo, Mitiko Gō

Protein Engineering, Design and Selection　Vol. 12　No. 8　p. 673-680　1999/08　Research paper (scientific journal)

Preparation of peptide thioester segments using Fmoc-solid-phase peptide synthesis and application of the thioester ligation strategy to the construction of TASP molecules

S Futaki, K Sogawa, M Fukuda, M Niwa, H Hojo

PEPTIDES: FRONTIERS OF PEPTIDES SCIENCE　p. 321-322　1999　Research paper (international conference proceedings)

Chemical synthesis of barnase which possesses phosphoserine residue in place of the catalytic glutamic acid at position 73

H Hojo, K Yamauchi, M Kinoshita, M Go, T Kawakami, S Aimoto

PEPTIDE SCIENCE - PRESENT AND FUTURE　p. 581-583　1999　Research paper (international conference proceedings)

Synthesis and structural characterization of triple-helical peptided which mimic the ligand binding site of the human macrophage scavenger receptor

Hironobu Hojo, Yoshiko Akamatsu, Kiyoshi Yamauchi, Masayoshi Kinoshita, Shunji Miki, Yu Nakamura

Tetrahedron　Vol. 53　No. 42　p. 14263-14274　1997/10/20　Research paper (scientific journal)

Preparation of peptide thioesters using Fmoc-solid-phase peptide synthesis and its application to the construction of a template-assembled synthetic protein (TASP)

Shiroh Futaki, Koji Sogawa, Jun Maruyama, Tomoko Asahara, Mineo Niwa, Hironobu Hojo

Tetrahedron Letters　Vol. 38　No. 35　p. 6237-6240　1997/09/01　Research paper (scientific journal)

Functional and possible physical association of scavenger receptor with cytoplasmic tyrosine kinase Lyn in monocytic THP-1-derived macrophages

Shunji Miki, Satoshi Tsukada, Yu Nakamura, Saburo Aimoto, Hironobu Hojo, Bunzo Sato, Masahiro Yamamoto, Yoshitsugu Miki

FEBS Letters　Vol. 399　No. 3　p. 241-244　1996/12/16　Research paper (scientific journal)

Synthesis and liposome-formation of a thermostable lipid bearing cell adhesion peptide sequence

Hironobu Hojo, Takashi Kojima, Kiyoshi Yamauchi, Masayoshi Kinoshita

Tetrahedron Letters　Vol. 37　No. 41　p. 7391-7394　1996/10　Research paper (scientific journal)

Synthesis and liposome-formation of a lipid bearing cell-adhesion peptide sequence

H Hojo, T Kojima, K Yamauchi, M Kinoshita

PEPTIDE CHEMISTRY 1995　p. 377-380　1996　Research paper (international conference proceedings)

Peptide Synthesis Mediated by Thiolsubtilisin Using Peptide Thioester as Building Block.

H. Mihara, S. Maeda, R. Kurosaki, S. Ueno, S. Sakamoto, T. Niidome, H. Hojo, S. Aimoto, H. Aoyagi

Chem. Lett.　1995/02　Research paper (scientific journal)

THIOLSUBTILISIN-CATALYZED PEPTIDE SYNTHESIS USING PEPTIDE THIOESTER SUBSTRATES AS BUILDING BLOCKS

H MIHARA, S MAEDA, R KUROSAKI, S UENO, S SAKAMOTO, T NIIDOME, H HOJO, S AIMOTO, H AOYAGI

PEPTIDE CHEMISTRY 1994　p. 205-208　1995　Research paper (international conference proceedings)

Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb

Kazuhiro Ogata, Souichi Morikawa, Haruki Nakamura, Hironobu Hojo, Shoko Yoshimura, Ruoheng Zhang, Saburo Aimoto, Yuko Ametani, Zenzo Hirata, Akinori Sarai, Shunsuke Ishii, Yoshifumi Nishimura

Nature Structural Biology　Vol. 2　No. 4　p. 309-320　1995　Research paper (scientific journal)

Preparation of S-Protected Cysteine-Containing Peptide Thioester and Its Use for the Synthesis of theBarnase-Like Domain in DNA-Directed RNA Polymerase II of Saccharomyces cerevisiae.

Hojo Hironobu, Yoshimura Shoko, Go Mitiko, Aimoto Saburo

Bull. Chem. Soc. Jpn.　Vol. 68　No. 1　p. 330-336　1994/08　Research paper (scientific journal)

13C-NMR relaxation study on mobility of the DNA-binding arm of HU

Yoshimitsu Kakuta, Hironobu Hojo, Saburo Aimoto, Isao Tanaka, Kunio Hikichi

Journal of Biochemistry　Vol. 116　No. 5　p. 1153-1155　1994　Research paper (scientific journal)

Synthesis of Barnase Site-Specifically Labelled with Two13C Atoms Using Partially Protected Peptide Thioester Building Blocks

Hironobu Hojo, Saburo Aimoto

Bulletin of the Chemical Society of Japan　Vol. 66　No. 10　p. 3004-3008　1993/10　Research paper (scientific journal)

Preparation of Partially Protected Peptide Thioesters Containing a Cysteine Residue and Their Segment Condensation

Yeondae Kwon, Ruoheng Zhang, Marcelo P. Bemquerer, Mineko Tominaga, Hironobu Hojo, Saburo Aimoto

Chemistry Letters　Vol. 22　No. 5　p. 881-884　1993/05　Research paper (scientific journal)

Development of a Linker with an Enhanced Stability for the Preparation of Peptide Thioesters and Its Application to the Synthesis of a Stable-Isotope-Labelled HU-Type DNA-Binding Protein

Hironobu Hojo, Yeondae Kwon, Yoshimitsu Kakuta, Sakae Tsuda, Isao Tanaka, Kunio Hikichi, Saburo Aimoto

Bulletin of the Chemical Society of Japan　Vol. 66　No. 9　p. 2700-2706　1993/04　Research paper (scientific journal)

PREPARATION OF PARTIALLY PROTECTED PEPTIDE THIOESTERS CONTAINING CYSTEINE RESIDUE AND THEIR SEGMENT CONDENSATION

Y KWON, RH ZHANG, H HOJO, S AIMOTO

PEPTIDE CHEMISTRY 1992　p. 58-60　1993　Research paper (international conference proceedings)

Solution structure of a DNA-binding unit of Myb: A helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core

Kazuhiro Ogata, Hironobu Hojo, Saburo Aimoto, Takahisa Nakai, Haruki Nakamura, Akinori Sarai, Shunsuke Ishii, Yoshifumi Nishimura

Proceedings of the National Academy of Sciences of the United States of America　Vol. 89　No. 14　p. 6428-6432　1992/07/15

Protein Synthesis Using S-Alkyl Thioester of Partially Protected Peptide Segments.

H. Hojo, S. Aimoto

Bull. Chem. Soc. Jpn.　1992/05　Research paper (scientific journal)

Assembly regulatory domain of glial fibrillary acidic protein. A single phosphorylation diminishes its assembly-accelerating property

Y. Nakamura, M. Takeda, S. Aimoto, H. Hojo, T. Takao, Y. Shimonishi, S. Hariguchi, T. Nishimura

Journal of Biological Chemistry　Vol. 267　No. 32　p. 23269-23274　1992　Research paper (scientific journal)

ROTATIONAL RESONANCE NMR MEASUREMENTS OF INTERNUCLEAR DISTANCES IN AN ALPHA-HELICAL PEPTIDE

OB PEERSEN, S YOSHIMURA, H HOJO, S AIMOTO, SO SMITH

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 114　No. 11　p. 4332-4335　1991/10　Research paper (scientific journal)

Pro‐peptide as an intermolecular chaperone: renaturation of denatured subtilisin E with a synthetic pro‐peptide

Y. Ohta, H. Hojo, S. Aimoto, T. Kobayashi, X. Zhu, F. Jordan, M. Inouye

Molecular Microbiology　Vol. 5　No. 6　p. 1507-1510　1991　Research paper (scientific journal)

A NEW ALPHA-HELICAL MOTIF IN MEMBRANE ACTIVE PEPTIDES

Y KOBAYASHI, A SATO, H TAKASHIMA, H TAMAOKI, S NISHIMURA, Y KYOGOKU, K IKENAKA, T KONDO, K MIKOSHIBA, H HOJO, S AIMOTO, L MORODER

NEUROCHEMISTRY INTERNATIONAL　Vol. 18　No. 4　p. 525-534　1991　Research paper (scientific journal)

Polypeptide Synthesis Using the S-Alkyl Thioester of a Partially Protected Peptide Segment. Synthesis of the DNA-Binding Domain of c-Myb Protein(142-193)-NH2.

H. Hojo, S. Aimoto

Bull. Chem. Soc. Jpn.　1990/08　Research paper (scientific journal)

Studies on the Disulfide Bridges of Sarafotoxins. Chemical Synthesis of Sarafotoxin S6b and Its Homologue with Different Disulfide Bridges.

S. Aimoto, H. Hojo, C. Takasaki

Biochemistry International　1990/07　Research paper (scientific journal)

Long-term enhancement of synaptic transmission by synthetic mast cell degranulating peptide and its localization of binding sites in hippocampus

Tetsuro Kondo, Kazuhiro Ikenaka, Hiroshi Kato, Ken-ichi Ito, Saburo Aimoto, Hironobu Hojo, Katsuhiko Mikoshiba

Neuroscience Research　Vol. 8　No. 3　p. 147-157　1990　Research paper (scientific journal)

MAST-CELL DEGRANULATING PEPTIDE FORMS VOLTAGE GATED AND CATION-SELECTIVE CHANNELS IN LIPID BILAYERS

T IDE, T TAGUCHI, T MORITA, M SATO, K IKENAKA, S AIMOTO, T KONDO, H HOJO, M KASAI, K MIKOSHIBA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 163　No. 1　p. 155-160　1989/08　Research paper (scientific journal)

DEVELOPMENT OF A FACILE METHOD FOR POLYPEPTIDE-SYNTHESIS - SYNTHESIS OF BOVINE PANCREATIC TRYPSIN-INHIBITOR (BPTI)

S AIMOTO, N MIZOGUCHI, H HOJO, S YOSHIMURA

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 62　No. 2　p. 524-531　1989/02　Research paper (scientific journal)