The XK plasma membrane scramblase and the VPS13A cytosolic lipid transporter for ATP-induced cell death.

Yuta Ryoden, Shigekazu Nagata

BioEssays : news and reviews in molecular, cellular and developmental biology　Vol. 44　No. 10　2022/10　Research paper (scientific journal)

Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta.

Yuki Ochiai, Chigure Suzuki, Katsumori Segawa, Yasuo Uchiyama, Shigekazu Nagata

Proceedings of the National Academy of Sciences of the United States of America　Vol. 119　No. 18　2022/05/03　Research paper (scientific journal)

Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells.

Yuta Ryoden, Katsumori Segawa, Shigekazu Nagata

Proceedings of the National Academy of Sciences of the United States of America　Vol. 119　No. 7　2022/02/15　Research paper (scientific journal)

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

Nicoletta Caronni, Giulia Maria Piperno, Francesca Simoncello, Oriana Romano, Simone Vodret, Yuichi Yanagihashi, Regine Dress, Charles-Antoine Dutertre, Mattia Bugatti, Pierre Bourdeley, Annalisa Del Prete, Tiziana Schioppa, Emilia Maria, Cristina Mazza, Licio Collavin, Serena Zacchigna, Renato Ostuni, Pierre Guermonprez, William Vermi, Florent Ginhoux, Silvio Bicciato, Shigekazu Nagata, Federica Benvenuti

Nature Communications　Vol. 12　No. 1　2021/12　Research paper (scientific journal)

ヒト細胞膜フリッパーゼATP11C構造機能解析

中西 華代, 瀬川 勝盛, 長田 重一, 藤吉 好則, 阿部 一啓

日本生化学会大会プログラム・講演要旨集　Vol. 94回　p. [P-176]　2021/11

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes.

Takaharu Sakuragi, Ryuta Kanai, Akihisa Tsutsumi, Hirotaka Narita, Eriko Onishi, Kohei Nishino, Takuya Miyazaki, Takeshi Baba, Hidetaka Kosako, Atsushi Nakagawa, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata

Nature structural & molecular biology　Vol. 28　No. 10　p. 825-834　2021/10　Research paper (scientific journal)

A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes

Katsumori Segawa, Atsuo Kikuchi, Tomoyasu Noji, Yuki Sugiura, Keita Hiraga, Chigure Suzuki, Kazuhiro Haginoya, Yasuko Kobayashi, Mitsuhiro Matsunaga, Yuki Ochiai, Kyoko Yamada, Takuo Nishimura, Shinya Iwasawa, Wataru Shoji, Fuminori Sugihara, Kohei Nishino, Hidetaka Kosako, Masahito Ikawa, Yasuo Uchiyama, Makoto Suematsu, Hiroshi Ishikita, Shigeo Kure, Shigekazu Nagata

Journal of Clinical Investigation　Vol. 131　No. 18　2021/09/15　Research paper (scientific journal)

An intramolecular scrambling path controlled by a gatekeeper in Xkr8 phospholipid scramblase

Takaharu Sakuragi, Ryuta Kanai, Akihisa Tsutsumi, Hirotaka Narita, Eriko Onishi, Takuya Miyazaki, Takeshi Baba, Atsushi Nakagawa, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata

2021/05/06

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.

Satoshi Omori, Misato Tsugita, Yasuto Hoshikawa, Masanobu Morita, Fumiya Ito, Shin-Ichiro Yamaguchi, Qilin Xie, Osamu Noyori, Tomoya Yamaguchi, Ayato Takada, Tatsuya Saitoh, Shinya Toyokuni, Hisaya Akiba, Shigekazu Nagata, Kengo Kinoshita, Masafumi Nakayama

Cell reports　Vol. 34　No. 6　p. 108734-108734　2021/02/09　Research paper (scientific journal)

Sensing and clearance of apoptotic cells.

Shigekazu Nagata, Katsumori Segawa

Current opinion in immunology　Vol. 68　p. 1-8　2021/02　Research paper (scientific journal)

Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.

Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe

Cell reports　Vol. 32　No. 13　p. 108208-108208　2020/09/29　Research paper (scientific journal)

病態の形成・進展、そして改善に関わるマクロファージ～最新知見を中心に～ リン脂質の膜動態とマクロファージ

瀬川 勝盛, 領田 優太, 長田 重一

日本生化学会大会プログラム・講演要旨集　Vol. 93回　p. [1S04e-01]　2020/09

ヒト細胞膜フリッパーゼATP11CのX線結晶構造解析

中西 華代, 入江 克雅, 瀬川 勝盛, 長田 重一, 長谷川 和也, 藤吉 好則, 阿部 一啓

日本生化学会大会プログラム・講演要旨集　Vol. 93回　p. [P-132]　2020/09

Crystal structure of a human plasma membrane phospholipid flippase.

Hanayo Nakanishi, Katsumasa Irie, Katsumori Segawa, Kazuya Hasegawa, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe

The Journal of biological chemistry　Vol. 295　No. 30　p. 10180-10194　2020/07/24　Research paper (scientific journal)

Flippase and scramblase for phosphatidylserine exposure.

Shigekazu Nagata, Takaharu Sakuragi, Katsumori Segawa

Current opinion in immunology　Vol. 62　p. 31-38　2020/02　Research paper (scientific journal)

Functional Expression of the P2X7 ATP Receptor Requires Eros

Yuta Ryoden, Toshihiro Fujii, Katsumori Segawa, Shigekazu Nagata

The Journal of Immunology　Vol. 204　No. 3　p. 559-568　2020/02/01　Research paper (scientific journal)

Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8-Deficient Male Mice.

Yahiro Yamashita, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata

Molecular and cellular biology　Vol. 40　No. 3　p. e00402-e00419　2020/01/16　Research paper (scientific journal)

Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure

Sakuragi, T., Kosako, H., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 8　p. 2907-2912　2019　Research paper (scientific journal)

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation

Nishi, C., Yanagihashi, Y., Segawa, K., Nagata, S.

Journal of Biological Chemistry　Vol. 294　No. 18　p. 7221-7230　2019　Research paper (scientific journal)

Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution

Tsuji, T., Cheng, J., Tatematsu, T., Ebata, A., Kamikawa, H., Fujita, A., Gyobu, S., Segawa, K., Arai, H., Taguchi, T., Nagata, S., Fujimoto, T.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 27　p. 13368-13373　2019　Research paper (scientific journal)

The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane

Segawa, K., Kurata, S., Nagata, S.

Journal of Biological Chemistry　Vol. 293　No. 6　p. 2172-2182　2018　Research paper (scientific journal)

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S.A., Abrams, J.M., Adam, D., Agostinis, P., Alnemri, E.S., Altucci, L., Amelio, I., Andrews, D.W., Annicchiarico-Petruzzelli, M., Antonov, A.V., Arama, E., Baehrecke, E.H., Barlev, N.A., Bazan, N.G., Bernassola, F., Bertrand, M.J.M., Bianchi, K., Blagosklonny, M.V., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F.K.-M., Chandel, N.S., Cheng, E.H., Chipuk, J.E., Cidlowski, J.A., Ciechanover, A., Cohen, G.M., Conrad, M., Cubillos-Ruiz, J.R., Czabotar, P.E., D'Angiolella, V., Dawson, T.M., Dawson, V.L., De Laurenzi, V., De Maria, R., Debatin, K.-M., Deberardinis, R.J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V.M., Dixon, S.J., Duckett, C.S., Dynlacht, B.D., El-Deiry, W.S., Elrod, J.W., Fimia, G.M., Fulda, S., García-Sáez, A.J., Garg, A.D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D.R., Greene, L.A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J.M., Harris, I.S., Hengartner, M.O., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P.J., Juin, P.P., Kaiser, W.J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R.N., Klionsky, D.J., Knight, R.A., Kumar, S., Lee, S.W., Lemasters, J.J., Levine, B., Linkermann, A., Lipton, S.A., Lockshin, R.A., López-Otín, C., Lowe, S.W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J.-C., Martin, S.J., Martinou, J.-C., Medema, J.P., Mehlen, P., Meier, P., Melino, S., Miao, E.A., Molkentin, J.D., Moll, U.M., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J.M., Pereira, D.M., Pervaiz, S., Peter, M.E., Piacentini, M., Pinton, P., Prehn, J.H.M., Puthalakath, H., Rabinovich, G.A., Rehm, M., Rizzuto, R., Rodrigues, C.M.P., Rubinsztein, D.C., Rudel, T., Ryan, K.M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H.-U., Sistigu, A., Stockwell, B.R., Strasser, A., Szabadkai, G., Tait, S.W.G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M.G., Villunger, A., Virgin, H.W., Vousden, K.H., Vucic, D., Wagner, E.F., Walczak, H., Wallach, D., Wang, Y., Wells, J.A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G., Kroemer, G.

Cell Death and Differentiation　Vol. 25　No. 3　p. 486-541　2018　Research paper (scientific journal)

Apoptosis and Clearance of Apoptotic Cells

Nagata, S.

Annual Review of Immunology　Vol. 36　p. 489-517　2018　Research paper (scientific journal)

Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase

Kawano, M., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 9　p. 2132-2137　2018　Research paper (scientific journal)

Efferocytosis and autoimmune disease

Kawano, M., Nagata, S.

International immunology　Vol. 30　No. 12　p. 551-558　2018　Research paper (scientific journal)

Single-molecule analysis of phospholipid scrambling by TMEM16F

Watanabe, R., Sakuragi, T., Noji, H., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 12　p. 3066-3071　2018　Research paper (scientific journal)

Phospholipid flippases enable precursor B cells to flee engulfment by macrophages

Segawa, K., Yanagihashi, Y., Yamada, K., Suzuki, C., Uchiyama, Y., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 48　p. 12212-12217　2018　Research paper (scientific journal)

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Nakaya, M., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Tsuda, M., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S., Kurose, H.

Journal of Clinical Investigation　Vol. 127　No. 1　p. 383-401　2017　Research paper (scientific journal)

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis

Yanagihashi, Y., Segawa, K., Maeda, R., Nabeshima, Y.-I., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 33　p. 8800-8805　2017　Research paper (scientific journal)

Characterization of the scrambling domain of the TMEM16 family

Gyobu, S., Ishihara, K., Suzuki, J., Segawa, K., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 24　p. 6274-6279　2017　Research paper (scientific journal)

Programmed cell death and the immune system

Nagata, S., Tanaka, M.

Nature Reviews Immunology　Vol. 17　No. 5　p. 333-340　2017　Research paper (scientific journal)

Exposure of phosphatidylserine on the cell surface

S. Nagata, J. Suzuki, K. Segawa, T. Fujii

Cell Death and Differentiation　Vol. 23　No. 6　p. 952-961　2016/06/01　Research paper (scientific journal)

Cell biology: Killer enzymes tethered.

Shigekazu Nagata

Nature　Vol. 533　No. 7604　p. 474-476　2016/05/26　Research paper (scientific journal)

Erratum: Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane (J. Biol. Chem. (2014) 289 (33543-33556))

Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K., Shin, H.-W.

Journal of Biological Chemistry　Vol. 291　No. 41　p. 21421-21421　2016　Research paper (scientific journal)

Human type IV P-type ATPases that work as plasma membrane phospholipid flippases and their regulation by caspase and calcium

Segawa, K., Kurata, S., Nagata, S.

Journal of Biological Chemistry　Vol. 291　No. 2　p. 762-772　2016　Research paper (scientific journal)

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

Suzuki, J., Imanishi, E., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 34　p. 9509-9514　2016　Research paper (scientific journal)

Role of Ca²⁺ in the Stability and Function of TMEM16F and 16K

Ishihara, K., Suzuki, J., Nagata, S.

Biochemistry　Vol. 55　No. 23　p. 3180-3188　2016　Research paper (scientific journal)

A role of TMEM16E carrying a scrambling domain in sperm motility

Gyobu, S., Miyata, H., Ikawa, M., Yamazaki, D., Takeshima, H., Suzuki, J., Nagata, S.

Molecular and Cellular Biology　Vol. 36　No. 4　p. 645-659　2016　Research paper (scientific journal)

Osteopontin in spontaneous germinal centers inhibits apoptotic cell engulfment and promotes anti-nuclear antibody production in lupus-prone mice

Sakamoto, K., Fukushima, Y., Ito, K., Matsuda, M., Nagata, S., Minato, N., Hattori, M.

Journal of Immunology　Vol. 197　No. 6　p. 2177-2186　2016　Research paper (scientific journal)

Erratum : Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis (Nature (1998) 391 (96-99)) DOI: 10.1038/34214)

Sakahira, H., Enari, M., Nagata, S.

Nature　Vol. 526　No. 7575　p. 728-728　2015　Research paper (scientific journal)

Clearance of Apoptotic Cells and Pyrenocytes

Toda, S., Nishi, C., Yanagihashi, Y., Segawa, K., Nagata, S.

Current Topics in Developmental Biology　Vol. 114　p. 267-295　2015　Research paper (scientific journal)

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

Fujii, T., Sakata, A., Nishimura, S., Eto, K., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 112　No. 41　p. 12800-12805　2015　Research paper (scientific journal)

An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure

Segawa, K., Nagata, S.

Trends in Cell Biology　Vol. 25　No. 11　p. 639-650　2015　Research paper (scientific journal)

DNA-mediated cyclic GMP-AMP synthase-dependent and -independent regulation of innate immune responses

Motani, K., Ito, S., Nagata, S.

Journal of Immunology　Vol. 194　No. 10　p. 4914-4923　2015　Research paper (scientific journal)

Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets

N. Yamamoto, H. Yamaguchi, K. Ohmura, T. Yokoyama, H. Yoshifuji, N. Yukawa, D. Kawabata, T. Fujii, S. Morita, S. Nagata, T. Mimori

Lupus　Vol. 23　No. 4　p. 386-394　2014　Research paper (scientific journal)

DNA degradation and its defects

Kawane, K., Motani, K., Nagata, S.

Cold Spring Harbor Perspectives in Biology　Vol. 6　No. 6　p. 141-154　2014　Research paper (scientific journal)

Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: Appropriating mitosis-related nuclear disassembly

Chaffee, B.R., Shang, F., Chang, M.-L., Clement, T.M., Eddy, E.M., Wagner, B.D., Nakahara, M., Nagata, S., Robinson, M.L., Taylor, A.

Development (Cambridge)　Vol. 141　No. 17　p. 3388-3398　2014　Research paper (scientific journal)

Phospholipid scrambling on the plasma membrane

Suzuki, J., Nagata, S.

Methods in Enzymology　Vol. 544　p. 381-393　2014　Research paper (scientific journal)

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells

Yamaguchi, H., Maruyama, T., Urade, Y., Nagata, S.

eLife　Vol. 2014　No. 3　2014　Research paper (scientific journal)

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

Toda, S., Segawa, K., Nagata, S.

Blood　Vol. 123　No. 25　p. 3963-3971　2014　Research paper (scientific journal)

Flippases and scramblases in the plasma membrane

Segawa, K., Suzuki, J., Nagata, S.

Cell Cycle　Vol. 13　No. 19　p. 2990-2991　2014　Research paper (scientific journal)

Exposure of phosphatidylserine by Xkrelated protein family members during apoptosis

Suzuki, J., Imanishi, E., Nagata, S.

Journal of Biological Chemistry　Vol. 289　No. 44　p. 30257-30267　2014　Research paper (scientific journal)

Functional swapping between transmembrane proteins TMEM16A and TMEM16F

Suzuki, T., Suzuki, J., Nagata, S.

Journal of Biological Chemistry　Vol. 289　No. 11　p. 7438-7447　2014　Research paper (scientific journal)

Tim4-and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages

Nishi, C., Toda, S., Segawa, K., Nagata, S.

Molecular and Cellular Biology　Vol. 34　No. 8　p. 1512-1520　2014　Research paper (scientific journal)

Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane

Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K., Shin, H.-W.

Journal of Biological Chemistry　Vol. 289　No. 48　p. 33543-33556　2014　Research paper (scientific journal)

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T.R., Matsuda, F., Nagata, S.

Science　Vol. 344　No. 6188　p. 1164-1168　2014　Research paper (scientific journal)

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids

Lauber, K., Keppeler, H., Munoz, L.E., Koppe, U., Schröder, K., Yamaguchi, H., Krönke, G., Uderhardt, S., Wesselborg, S., Belka, C., Nagata, S., Herrmann, M.

Cell Death and Differentiation　Vol. 20　No. 9　p. 1230-1240　2013　Research paper (scientific journal)

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages

Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S., Suda, T.

International Immunology　Vol. 25　No. 6　p. 363-372　2013　Research paper (scientific journal)

Calcium-dependent phospholipid scramblase activity of TMEM 16 protein family members

Suzuki, J., Fujii, T., Imao, T., Ishihara, K., Kuba, H., Nagata, S.

Journal of Biological Chemistry　Vol. 288　No. 19　p. 13305-13316　2013　Research paper (scientific journal)

Biogenesis and Proteolytic Processing of Lysosomal DNase II

Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Safig, P., Peters, C., Nagata, S., Uchiyama, Y.

PLoS ONE　Vol. 8　No. 3　2013　Research paper (scientific journal)

Apaf-1- and Caspase-8-independent apoptosis

Imao, T., Nagata, S.

Cell Death and Differentiation　Vol. 20　No. 2　p. 343-352　2013　Research paper (scientific journal)

Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells

Suzuki, J., Denning, D.P., Imanishi, E., Horvitz, H.R., Nagata, S.

Science　Vol. 341　No. 6144　p. 403-406　2013　Research paper (scientific journal)

Constitutive exposure of phosphatidylserine on viable cells (vol 108, pg 19246, 2011)

Katsumori Segawa, Jun Suzuki, Shigekazu Nagata

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 109　No. 3　p. 995-995　2012/01

Pillars article: lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. 1992.

Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., Nagata, S.

Journal of immunology (Baltimore, Md. : 1950)　Vol. 189　No. 11　p. 5101-4　2012　Research paper (scientific journal)

Synergistic effect of TIM4 and MFG-E8 null mutations on the development of autoimmunity

Miyanishi, M., Segawa, K., Nagata, S.

International Immunology　Vol. 24　No. 9　p. 551-559　2012　Research paper (scientific journal)

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif

Liu, X., Sano, T., Guan, Y., Nagata, S., Hoffmann, J.A., Fukuyama, H.

PLoS ONE　Vol. 7　No. 8　2012　Research paper (scientific journal)

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

Nakahashi-Oda, C., Tahara-Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S., Shibuya, K., Nagata, S., Shibuya, A.

Journal of Experimental Medicine　Vol. 209　No. 8　p. 1493-1503　2012　Research paper (scientific journal)

Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections

Alonzo, M.T.G., Lacuesta, T.L.V., Dimaano, E.M., Kurosu, T., Suarez, L.-A.C., Mapua, C.A., Akeda, Y., Matias, R.R., Kuter, D.J., Nagata, S., Natividad, F.F., Oishi, K.

Journal of Infectious Diseases　Vol. 205　No. 8　p. 1321-1329　2012　Research paper (scientific journal)

Two-step engulfment of apoptotic cells

Toda, S., Hanayama, R., Nagata, S.

Molecular and Cellular Biology　Vol. 32　No. 1　p. 118-125　2012　Research paper (scientific journal)

Jurg Tschopp-1951-2011-an immortal contribution Obituary

G. Kroemer, F. Martinon, S. Lippens, D. R. Green, R. Knight, P. Vandenabeele, M. Piacentini, S. Nagata, C. Borner, H-U Simon, P. Krammer, G. Melino

CELL DEATH AND DIFFERENTIATION　Vol. 18　No. 7　p. 1087-1088　2011/07

Constitutive exposure of phosphatidylserine on viable cells

Segawa, K., Suzuki, J., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 108　No. 48　p. 19246-192451　2011　Research paper (scientific journal)

Characterization of the threonine-phosphatase of mouse eyes absent 3

Sano, T., Nagata, S.

FEBS Letters　Vol. 585　No. 17　p. 2714-2719　2011　Research paper (scientific journal)

Autoinflammation by endogenous DNA

Nagata, S., Kawane, K.

Advances in Immunology　Vol. 110　p. 139-161　2011　Research paper (scientific journal)

Lysosomal Dnase II Digests Mitochondrial DNA Through Lysosome/Autophagy System to Maintain Cardiac Function in Pressured-Overloaded Hearts

Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Toshihiro Takeda, Kazuhiko Nishida, Kohki Kawane, Issei Komuro, Shigekazu Nagata, Kinya Otsu

CIRCULATION　Vol. 122　No. 21　2010/11

Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation

Kawane, K., Tanaka, H., Kitahara, Y., Shimaoka, S., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 107　No. 45　p. 19432-19437　2010　Research paper (scientific journal)

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

Östberg, T., Kawane, K., Nagata, S., Yang, H., Chavan, S., Klevenvall, L., Bianchi, M.E., Harris, H.E., Andersson, U., Palmblad, K.

Arthritis and Rheumatism　Vol. 62　No. 10　p. 2963-2972　2010　Research paper (scientific journal)

Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression

Fujii, T., Ueda, T., Nagata, S., Fukunaga, R.

Journal of Biological Chemistry　Vol. 285　No. 39　p. 30214-30223　2010　Research paper (scientific journal)

Interferon-induced TRAIL-independent cell death in DNase II^-/- embryos

Kitahara, Y., Kawane, K., Nagata, S.

European Journal of Immunology　Vol. 40　No. 9　p. 2590-2598　2010　Research paper (scientific journal)

Apaf-1-independent programmed cell death in mouse development

Nagasaka, A., Kawane, K., Yoshida, H., Nagata, S.

Cell Death and Differentiation　Vol. 17　No. 6　p. 931-941　2010　Research paper (scientific journal)

Autoimmunity and the Clearance of Dead Cells

Nagata, S., Hanayama, R., Kawane, K.

Cell　Vol. 140　No. 5　p. 619-630　2010　Research paper (scientific journal)

Apoptosis and autoimmune diseases

Nagata, S.

Annals of the New York Academy of Sciences　Vol. 1209　No. 1　p. 10-16　2010　Research paper (scientific journal)

Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus

Yamaguchi, H., Fujimoto, T., Nakamura, S., Ohmura, K., Mimori, T., Matsuda, F., Nagata, S.

European Journal of Immunology　Vol. 40　No. 6　p. 1778-1785　2010　Research paper (scientific journal)

Calcium-dependent phospholipid scrambling by TMEM16F

Suzuki, J., Umeda, M., Sims, P.J., Nagata, S.

Nature　Vol. 468　No. 7325　p. 834-838　2010　Research paper (scientific journal)

The Many Roles of FAS Receptor Signaling in the Immune System

Strasser, A., Jost, P.J., Nagata, S.

Immunity　Vol. 30　No. 2　p. 180-192　2009　Research paper (scientific journal)

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

Galluzzi, L., Aaronson, S.A., Abrams, J., Alnemri, E.S., Andrews, D.W., Baehrecke, E.H., Bazan, N.G., Blagosklonny, M.V., Blomgren, K., Borner, C., Bredesen, D.E., Brenner, C., Castedo, M., Cidlowski, J.A., Ciechanover, A., Cohen, G.M., De Laurenzi, V., De Maria, R., Deshmukh, M., Dynlacht, B.D., El-Deiry, W.S., Flavell, R.A., Fulda, S., Garrido, C., Golstein, P., Gougeon, M.-L., Green, D.R., Gronemeyer, H., Hajnóczky, G., Hardwick, J.M., Hengartner, M.O., Ichijo, H., Jäättelä, M., Kepp, O., Kimchi, A., Klionsky, D.J., Knight, R.A., Kornbluth, S., Kumar, S., Levine, B., Lipton, S.A., Lugli, E., Madeo, F., Malorni, W., Marine, J.-C.W., Martin, S.J., Medema, J.P., Mehlen, P., Melino, G., Moll, U.M., Morselli, E., Nagata, S., Nicholson, D.W., Nicotera, P., Nuñez, G., Oren, M., Penninger, J., Pervaiz, S., Peter, M.E., Piacentini, M., Prehn, J.H.M., Puthalakath, H., Rabinovich, G.A., Rizzuto, R., Rodrigues, C.M.P., Rubinsztein, D.C., Rudel, T., Scorrano, L., Simon, H.-U., Steller, H., Tschopp, J., Tsujimoto, Y., Vandenabeele, P., Vitale, I., Vousden, K.H., Youle, R.J., Yuan, J., Zhivotovsky, B., Kroemer, G.

Cell Death and Differentiation　Vol. 16　No. 8　p. 1093-1107　2009　Research paper (scientific journal)

Lactadherin and clearance of platelet-derived microvesicles

Dasgupta, S.K., Abdel-Monem, H., Niravath, P., Le, A., Bellera, R.V., Langlois, K., Nagata, S., Rumbaut, R.E., Thiagarajan, P.

Blood　Vol. 113　No. 6　p. 1332-1339　2009　Research paper (scientific journal)

Regulation of the innate immune response by threonine-phosphatase of Eyes absent

Okabe, Y., Sano, T., Nagata, S.

Nature　Vol. 460　No. 7254　p. 520-524　2009　Research paper (scientific journal)

Nucleases in Programmed Cell Death.

Kawane, K, Nagata, S

Int Immunol., 24: 551-559　2008

IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation

Okabe, Y., Kawane, K., Nagata, S.

European Journal of Immunology　Vol. 38　No. 11　p. 3150-3158　2008　Research paper (scientific journal)

Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cells

Dasgupta, S.K., Abdel-Monem, H., Guchhait, P., Nagata, S., Thiagarajan, P.

Transfusion　Vol. 48　No. 11　p. 2370-2376　2008　Research paper (scientific journal)

Chapter Fourteen Nucleases in Programmed Cell Death

Kawane, K., Nagata, S.

Methods in Enzymology　Vol. 442　p. 271-287　2008　Research paper (scientific journal)

Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus

Yamaguchi, H., Takagi, J., Miyamae, T., Yokota, S., Fujimoto, T., Nakamura, S., Ohshima, S., Naka, T., Nagata, S.

Journal of Leukocyte Biology　Vol. 83　No. 5　p. 1300-1307　2008　Research paper (scientific journal)

Rheumatoid polyarthritis caused by a defect in DNA degradation

Nagata, S.

Cytokine and Growth Factor Reviews　Vol. 19　No. 3-4　p. 295-302　2008　Research paper (scientific journal)

Essential role of C/EBPα in G-CSF-induced transcriptional activation and chromatin modification of myeloid-specific genes

Iida, S., Watanabe-Fukunaga, R., Nagata, S., Fukunaga, R.

Genes to Cells　Vol. 13　No. 4　p. 313-327　2008　Research paper (scientific journal)

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., Tanaka, K., Uchiyama, Y.

American Journal of Pathology　Vol. 172　No. 2　p. 454-469　2008　Research paper (scientific journal)

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Kitano, M., Nakaya, M., Nakamura, T., Nagata, S., Matsuda, M.

Nature　Vol. 453　No. 7192　p. 241-245　2008　Research paper (scientific journal)

Erratum: Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages (Nature (2006) 443, (998-1002))

Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., Yoshikawa, H., Nagata, S.

Nature　Vol. 446　No. 7131　p. 102-102　2007　Research paper (scientific journal)

Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis

Ueda, T., Watanabe-fukunaga, R., Ogawa, H., Fukuyama, H., Higashi, Y., Nagata, S., Fukunaga, R.

Genes to Cells　Vol. 12　No. 5　p. 581-592　2007　Research paper (scientific journal)

Bridge over troubled water: Milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells [2]

Witasp, E., Uthaisang, W., Elenström-Magnusson, C., Hanayama, R., Tanaka, M., Nagata, S., Orrenius, S., Fadeel, B.

Cell Death and Differentiation　Vol. 14　No. 5　p. 1063-1065　2007　Research paper (scientific journal)

Identification of Tim4 as a phosphatidylserine receptor

Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., Nagata, S.

Nature　Vol. 450　No. 7168　p. 435-439　2007　Research paper (scientific journal)

Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors

Nagata, S.

Immunological Reviews　Vol. 220　No. 1　p. 237-250　2007　Research paper (scientific journal)

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

Nakahara, M., Nagasaka, A., Koike, M., Uchida, K., Kawane, K., Uchiyama, Y., Nagata, S.

FEBS Journal　Vol. 274　No. 12　p. 3055-3064　2007　Research paper (scientific journal)

MFG-E8 in the retina and retinal pigment epithelium of rat and mouse

Burgess, B.L., Abrams, T.A., Nagata, S., Hall, M.O.

Molecular Vision　Vol. 12　No. 162　p. 1437-1447　2006　Research paper (scientific journal)

MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure.

Hanayama, R., Miyasaka, K., Nakaya, M., Nagata, S.

Current directions in autoimmunity　Vol. 9　p. 162-172　2006　Research paper (scientific journal)

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., Yoshikawa, H., Nagata, S.

Nature　Vol. 443　No. 7114　p. 998-1002　2006　Research paper (scientific journal)

Apoptosis and autoimmune diseases

Nagata, S.

IUBMB Life　Vol. 58　No. 5-6　p. 358-362　2006　Research paper (scientific journal)

Opposite effects of Rho family GTPases on engulfment of apoptotic cells by macrophages

Nakaya, M., Tanaka, M., Okabe, Y., Hanayama, R., Nagata, S.

Journal of Biological Chemistry　Vol. 281　No. 13　p. 8836-8842　2006　Research paper (scientific journal)

DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA

Bergsmedh, A., Ehnfors, J., Kawane, K., Motoyama, N., Nagata, S., Holmgren, L.

Molecular Cancer Research　Vol. 4　No. 3　p. 187-195　2006　Research paper (scientific journal)

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

Yoshida, H., Kawane, K., Koike, M., Mori, Y., Uchiyama, Y., Nagata, S.

Nature　Vol. 437　No. 7059　p. 754-758　2005　Research paper (scientific journal)

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

Okabe, Y., Kawane, K., Akira, S., Taniguchi, T., Nagata, S.

Journal of Experimental Medicine　Vol. 202　No. 10　p. 1333-1339　2005　Research paper (scientific journal)

SEI family of nuclear factors regulates p53-dependent transcriptional activation

Watanabe-Fukunaga, R., Iida, S., Shimizu, Y., Nagata, S., Fukunaga, R.

Genes to Cells　Vol. 10　No. 8　p. 851-860　2005　Research paper (scientific journal)

Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation

Iida, S., Kohro, T., Kodama, T., Nagata, S., Fukunaga, R.

Journal of Leukocyte Biology　Vol. 78　No. 2　p. 481-490　2005　Research paper (scientific journal)

Classification of cell death: Recommendations of the nomenclature committee on cell death

Kroemer, G., El-Deiry, W.S., Golstein, P., Peter, M.E., Vaux, D., Vandenabeele, P., Zhivotovsky, B., Blagosklonny, M.V., Malorni, W., Knight, R.A., Piacentini, M., Nagata, S., Melino, G.

Cell Death and Differentiation　Vol. 12　No. SUPPL. 2　p. 1463-1467　2005　Research paper (scientific journal)

Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons

Ohnishi, H., Kaneko, Y., Okazawa, H., Miyashita, M., Sato, R., Hayashi, A., Tada, K., Nagata, S., Takahashi, M., Matozaki, T.

Journal of Neuroscience　Vol. 25　No. 10　p. 2702-2711　2005　Research paper (scientific journal)

DNA degradation in development and programmed cell death

Nagata, S.

Annual Review of Immunology　Vol. 23　p. 853-875　2005　Research paper (scientific journal)

Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA

Yoshida, H., Okabe, Y., Kawane, K., Fukuyama, H., Nagata, S.

Nature Immunology　Vol. 6　No. 1　p. 49-56　2005　Research paper (scientific journal)

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., Nagata, S.

Science　Vol. 304　No. 5674　p. 1147-1150　2004　Research paper (scientific journal)

Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells

Hanayama, R., Tanaka, M., Miwa, K., Nagata, S.

Journal of Immunology　Vol. 172　No. 6　p. 3876-3882　2004　Research paper (scientific journal)

Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice

Asano, K., Miwa, M., Miwa, K., Hanayama, R., Nagase, H., Nagata, S., Tanaka, M.

Journal of Experimental Medicine　Vol. 200　No. 4　p. 459-467　2004　Research paper (scientific journal)

Early work on the function of CD95, an interview with Shige Nagata

Nagata, S.

Cell Death and Differentiation　Vol. 11　No. SUPPL. 1　p. S23-S27　2004　Research paper (scientific journal)

Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif

Shiraishi, T., Suzuyama, K., Okamoto, H., Mineta, T., Tabuchi, K., Nakayama, K., Shimizu, Y., Tohma, J., Ogihara, T., Naba, H., Mochizuki, H., Nagata, S.

Biochemical and Biophysical Research Communications　Vol. 322　No. 1　p. 197-202　2004　Research paper (scientific journal)

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

Ueda, T., Watanabe-Fukunaga, R., Fukuyama, H., Nagata, S., Fukunaga, R.

Molecular and Cellular Biology　Vol. 24　No. 15　p. 6539-6549　2004　Research paper (scientific journal)

SOCS-1 suppresses TNF-α-induced apoptosis through the regulation of Jak activation

Kimura, A., Naka, T., Nagata, S., Kawase, I., Kishimoto, T.

International Immunology　Vol. 16　No. 7　p. 991-999　2004　Research paper (scientific journal)

Intraperitoneal injection of lipopolysaccharide induces dynamic migration of Gr-1^high polymorphonuclear neutrophils in the murine abdominal cavity

Miyazaki, S., Ishikawa, F., Fujikawa, T., Nagata, S., Yamaguchi, K.

Clinical and Diagnostic Laboratory Immunology　Vol. 11　No. 3　p. 452-457　2004　Research paper (scientific journal)

Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells

Miyasaka, K., Hanayama, R., Tanaka, M., Nagata, S.

European Journal of Immunology　Vol. 34　No. 5　p. 1414-1422　2004　Research paper (scientific journal)

Tethering of Apoptotic Cells to Phagocytes through Binding of CD47 to Src Homology 2 Domain-Bearing Protein Tyrosine Phosphatase Substrate-1

Tada, K., Tanaka, M., Hanayama, R., Miwa, K., Shinohara, A., Iwamatsu, A., Nagata, S.

Journal of Immunology　Vol. 171　No. 11　p. 5718-5726　2003　Research paper (scientific journal)

Degradation of chromosomal DNA during apoptosis

Nagata, S., Nagase, H., Kawane, K., Mukae, N., Fukuyama, H.

Cell Death and Differentiation　Vol. 10　No. 1　p. 108-116　2003　Research paper (scientific journal)

Membrane-anchored CD40 is processed by the tumor necrosis factor-α-converting enzyme: Implications for CD40 signaling

Contin, C., Pitard, V., Itai, T., Nagata, S., Moreau, J.-F., Déchanet-Merville, J.

Journal of Biological Chemistry　Vol. 278　No. 35　p. 32801-32809　2003　Research paper (scientific journal)

Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens

Nishimoto, S., Kawane, K., Watanabe-Fukunaga, R., Fukuyama, H., Ohsawa, Y., Uchiyama, Y., Hashida, N., Ohguro, N., Tano, Y., Morimoto, T., Fukuda, Y., Nagata, S.

Nature　Vol. 424　No. 6952　p. 1071-1074　2003　Research paper (scientific journal)

Regulation of myeloid zinc finger protein 2A transactivation activity through phosphorylation by mitogen-activated protein kinases

Ogawa, H., Murayama, A., Nagata, S., Fukunaga, R.

Journal of Biological Chemistry　Vol. 278　No. 5　p. 2921-2927　2003　Research paper (scientific journal)

A SW12/SNF2-type ATPase/helicase protein, mDomino, interacts with myeloid zinc finger protein 2A (MZF-2A) to regulate its transcriptional activity

Ogawa, H., Ueda, T., Aoyama, T., Aronheim, A., Nagata, S., Fukunaga, R.

Genes to Cells　Vol. 8　No. 4　p. 325-339　2003　Research paper (scientific journal)

Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation

Kawane, K., Fukuyama, H., Yoshida, H., Nagase, H., Ohsawa, Y., Uchiyama, Y., Okada, K., Iida, T., Nagata, S.

Nature Immunology　Vol. 4　No. 2　p. 138-144　2003　Research paper (scientific journal)

Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation [1]

Nagase, H., Fukuyama, H., Kawane, K., Nagata, S.

Cell Death and Differentiation　Vol. 10　No. 1　p. 142-143　2003　Research paper (scientific journal)

Identification of a factor that links apoptotic cells to phagocytes

Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., Nagata, S.

Nature　Vol. 417　No. 6885　p. 182-187　2002　Research paper (scientific journal)

The evolutionary conservation of the mammalian peroxidase genes

Sakamaki, K., Ueda, T., Nagata, S.

Cytogenetic and Genome Research　Vol. 98　No. 1　p. 93-95　2002　Research paper (scientific journal)

Increased plasma levels of the soluble form of Fas ligand in patients with acute myocardial infarction and unstable angina pectoris

Shimizu, M., Fukuo, K., Nagata, S., Suhara, T., Okuro, M., Fujii, K., Higashino, Y., Mogi, M., Hatanaka, Y., Ogihara, T.

Journal of the American College of Cardiology　Vol. 39　No. 4　p. 585-590　2002　Research paper (scientific journal)

Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation

Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Nagata, S.

Genes and Development　Vol. 16　No. 20　p. 2662-2671　2002　Research paper (scientific journal)

Frequent mutations of Fas gene in nasal NK/T cell lymphoma

Takakuwa, T., Dong, Z., Nakatsuka, S., Kojya, S., Harabuchi, Y., Yang, W.-I., Nagata, S., Aozasa, K.

Oncogene　Vol. 21　No. 30　p. 4702-4705　2002　Research paper (scientific journal)

Frequent Fas gene mutations in testicular germ cell tumors

Takayama, H., Takakuwa, T., Tsujimoto, Y., Tani, Y., Nonomura, N., Okuyama, A., Nagata, S., Aozasa, K.

American Journal of Pathology　Vol. 161　No. 2　p. 635-641　2002　Research paper (scientific journal)

Co-translational folding of caspase-activated DNase with Hsp70, Hsp40, and inhibitor of caspase-activated DNase

Sakahira, H., Nagata, S.

Journal of Biological Chemistry　Vol. 277　No. 5　p. 3364-3370　2002　Research paper (scientific journal)

Breakdown of chromosomal DNA

Nagata, S.

Cornea　Vol. 21　No. 2 SUPPL. 1　p. S2-S6　2002　Research paper (scientific journal)

Requirement of Fas expression in B cells for tolerance induction

Fukuyama, H., Adachi, M., Suematsu, S., Miwa, K., Suda, T., Yoshida, N., Nagata, S.

European Journal of Immunology　Vol. 32　No. 1　p. 223-230　2002　Research paper (scientific journal)

Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination

Koike, H., Horie, K., Fukuyama, H., Kondoh, G., Nagata, S., Takeda, J.

EMBO Reports　Vol. 3　No. 5　p. 433-437　2002　Research paper (scientific journal)

Molecular mechanism of apoptosis : Why cells die?

Nagata S.

Seibutsu Butsuri　Vol. 41　2001

Testicular FasL is expressed by sperm cells

D'Alessio, A., Riccioli, A., Lauretti, P., Padula, F., Muciaccia, B., De Cesaris, P., Filippini, A., Nagata, S., Ziparo, E.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 98　No. 6　p. 3316-3321　2001　Research paper (scientific journal)

Frequent mutations of Fas gene in thyroid lymphoma

Takakuwa, T., Dong, Z., Takayama, H., Matsuzuka, F., Nagata, S., Aozasa, K.

Cancer Research　Vol. 61　No. 4　p. 1382-1385　2001　Research paper (scientific journal)

Fas gene mutations in prostatic intraepithelial neoplasia and concurrent carcinoma: Analysis of laser capture microdissected specimens

Takayama, H., Takakuwa, T., Dong, Z., Nonomura, N., Okuyama, A., Nagata, S., Aozasa, K.

Laboratory Investigation　Vol. 81　No. 3　p. 283-288　2001　Research paper (scientific journal)

Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

Kawane, K., Fukuyama, H., Kondoh, G., Takeda, J., Ohsawa, Y., Uchiyama, Y., Nagata, S.

Science　Vol. 292　No. 5521　p. 1546-1549　2001　Research paper (scientific journal)

The Fused Protein Kinase Regulates Hedgehog-stimulated Transcriptional Activation in Drosophila Schneider 2 Cells

Fukumoto, T., Watanabe-Fukunaga, R., Fujisawa, K., Nagata, S., Fukunaga, R.

Journal of Biological Chemistry　Vol. 276　No. 42　p. 38441-38448　2001　Research paper (scientific journal)

Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia

Tsuda, T., Ohmori, Y., Muramatsu, H., Hosaka, Y., Takiguchi, K., Saitoh, F., Kato, K., Nakayama, K., Nakamura, N., Nagata, S., Mochizuki, H.

European Journal of Pharmacology　Vol. 433　No. 1　p. 37-45　2001　Research paper (scientific journal)

Enzymatic active site of caspase-activated DNase (CAD) and its inhibition by inhibitor of CAD

Sakahira, H., Takemura, Y., Nagata, S.

Archives of Biochemistry and Biophysics　Vol. 388　No. 1　p. 91-99　2001　Research paper (scientific journal)

The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity

Shudo, K., Kinoshita, K., Imamura, R., Fan, H., Hasumoto, K., Tanaka, M., Nagata, S., Suda, T.

European Journal of Immunology　Vol. 31　No. 8　p. 2504-2511　2001　Research paper (scientific journal)

Processing of tumor necrosis factor by the membrane-bound TNF-α-converting enzyme, but not its truncated soluble form

Itai, T., Tanaka, M., Nagata, S.

European Journal of Biochemistry　Vol. 268　No. 7　p. 2074-2082　2001　Research paper (scientific journal)

Evidence that 3 '-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P-2

T Yokogawa, S Nagata, Y Nishio, T Tsutsumi, S Ihara, R Shirai, K Morita, M Umeda, Y Shirai, N Saitoh, Y Fukui

FEBS LETTERS　Vol. 473　No. 2　p. 222-226　2000/05　Research paper (scientific journal)

Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure

Ryo, K., Kamogawa, Y., Ikeda, I., Yamauchi, K., Yonehara, S., Nagata, S., Hayashi, N.

American Journal of Gastroenterology　Vol. 95　No. 8　p. 2047-2055　2000　Research paper (scientific journal)

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor α-induced cell death in fibroblasts

Morita, Y., Naka, T., Kawazoe, Y., Fujimoto, M., Narazaki, M., Nakagawa, R., Fukuyama, H., Nagata, S., Kishimoto, T.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 97　No. 10　p. 5405-5410　2000　Research paper (scientific journal)

LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

Tamada, K., Shimozaki, K., Chapoval, A.I., Zhai, Y., Su, J., Chen, S.-F., Hsieh, S.-L., Nagata, S., Ni, J., Chen, L.

Journal of Immunology　Vol. 164　No. 8　p. 4105-4110　2000　Research paper (scientific journal)

An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes

McIlroy, D., Tanaka, M., Sakahira, H., Fukuyama, H., Suzuki, M., Yamamura, K.-I., Ohsawa, Y., Uchiyama, Y., Nagata, S.

Genes and Development　Vol. 14　No. 5　p. 549-558　2000　Research paper (scientific journal)

Apoptosis

Nagata, S.

Fibrinolysis and Proteolysis　Vol. 14　No. 2-3　p. 82-86　2000　Research paper (scientific journal)

The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase and lactoperoxidase on human chromosome 17

Sakamaki, K., Kanda, N., Ueda, T., Aikawa, E., Nagata, S.

Cytogenetics and Cell Genetics　Vol. 88　No. 3-4　p. 246-248　2000　Research paper (scientific journal)

A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster

Yokoyama, H., Mukae, N., Sakahira, H., Okawa, K., Iwamatsu, A., Nagata, S.

Journal of Biological Chemistry　Vol. 275　No. 17　p. 12978-12986　2000　Research paper (scientific journal)

Intrathecal administration of neutralizing antibody against Fas ligand suppresses the progression of experimental autoimmune encephalomyelitis

Okuda, Y., Sakoda, S., Fujimura, H., Nagata, S., Yanagihara, T., Bernard, C.C.A.

Biochemical and Biophysical Research Communications　Vol. 275　No. 1　p. 164-168　2000　Research paper (scientific journal)

Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNase

Sakahira, H., Iwamatsu, A., Nagata, S.

Journal of Biological Chemistry　Vol. 275　No. 11　p. 8091-8096　2000　Research paper (scientific journal)

Identification and developmental expression of inhibitor of caspase- activated DNase (ICAD) in Drosophila melanogaster

Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Sakahira, H., Nagata, S.

Journal of Biological Chemistry　Vol. 275　No. 28　p. 21402-21408　2000　Research paper (scientific journal)

Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor

Uegaki, K., Otomo, T., Sakahira, H., Shimizu, M., Yumoto, N., Kyogoku, Y., Nagata, S., Yamazaki, T.

Journal of Molecular Biology　Vol. 297　No. 5　p. 1121-1128　2000　Research paper (scientific journal)

Necrotic death pathway in Fas receptor signaling

Matsumura, H., Shimizu, Y., Ohsawa, Y., Kawahara, A., Uchiyama, Y., Nagata, S.

Journal of Cell Biology　Vol. 151　No. 6　p. 1247-1255　2000　Research paper (scientific journal)

Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis

Munsch, D., Watanabe-Fukunaga, R., Bourdon, J.-C., Nagata, S., May, E., Yonish-Rouach, E., Reisdorf, P.

Journal of Biological Chemistry　Vol. 275　No. 6　p. 3867-3872　2000　Research paper (scientific journal)

Apoptotic DNA fragmentation

Nagata, S.

Experimental Cell Research　Vol. 256　No. 1　p. 12-18　2000　Research paper (scientific journal)

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

Tamada, K., Shimozaki, K., Chapoval, A.I., Zhu, G., Sica, G., Flies, D., Boone, T., Hsu, H., Fu, Y.-X., Nagata, S., Ni, J., Chen, L.

Nature Medicine　Vol. 6　No. 3　p. 283-289　2000　Research paper (scientific journal)

Deregulation of the CD95/CD95L system in lymphocytes from patients with primary acute HIV infection

Cossarizza, A., Stent, G., Mussini, C., Paganelli, R., Borghi, V., Nuzzo, C., Pinti, M., Pedrazzi, J., Benatti, F., Esposito, R., Røsok, B., Nagata, S., Vella, S., Franceschi, C., De Rienzo, B.

AIDS　Vol. 14　No. 4　p. 345-355　2000　Research paper (scientific journal)

Steering anti-cancer drugs away from the TRAIL

Nagata, S.

Nature Medicine　Vol. 6　No. 5　p. 502-503　2000　Research paper (scientific journal)

Fas-mediated cholangiopathy in the murine model of graft versus host disease

Ueno, Y., Ishii, M., Yahagi, K., Mano, Y., Kisara, N., Nakamura, N., Shimosegawa, T., Toyota, T., Nagata, S.

Hepatology　Vol. 31　No. 4　p. 966-974　2000　Research paper (scientific journal)

Soluble Fas ligand expression in the ocular fluids of uveitis patients

Sotozono, C., Sano, Y., Suzuki, T., Tada, R., Ikeda, T., Nagata, S., Kinoshita, S.

Current Eye Research　Vol. 20　No. 1　p. 54-57　2000　Research paper (scientific journal)

Structure of the heterodimeric complex between CAD domains of CAD and ICAD

Otomo, T., Sakahira, H., Uegaki, K., Nagata, S., Yamazaki, T.

Nature Structural Biology　Vol. 7　No. 8　p. 658-662　2000　Research paper (scientific journal)

Mice with markedly reduced PACAP (PAC <inf>1</inf> ) receptor expression by targeted deletion of the signal peptide

Hashimoto, H., Shintani, N., Nishino, A., Okabe, M., Ikawa, M., Matsuyama, S., Itoh, K., Yamamoto, K., Tomimoto, S., Fujita, T., Hagihara, N., Mori, W., Koyama, Y., Matsuda, T., Nagata, S., Baba, A.

Journal of Neurochemistry　Vol. 75　No. 5　p. 1810-1817　2000　Research paper (scientific journal)

Biddable death

Nagata, S.

Nature Cell Biology　Vol. 1　No. 6　p. E143-E145　1999　Research paper (scientific journal)

Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin- induced tumor apoptosis, respectively

Hashimoto, W., Osaki, T., Okamura, H., Robbins, P.D., Kurimoto, M., Nagata, S., Lotze, M.T., Tahara, H.

Journal of Immunology　Vol. 163　No. 2　p. 583-589　1999　Research paper (scientific journal)

Apoptotic nuclear morphological change without DNA fragmentation

Sakahira, H., Enari, M., Ohsawa, Y., Uchiyama, Y., Nagata, S.

Current Biology　Vol. 9　No. 10　p. 543-546　1999　Research paper (scientific journal)

Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC<inf>1</inf>) receptor

Hashimoto, H., Nishino, A., Shintani, N., Hagihara, N., Copeland, N.G., Jenkins, N.A., Yamamoto, K., Matsuda, T., Ishihara, T., Nagata, S., Baba, A.

Genomics　Vol. 58　No. 1　p. 90-93　1999　Research paper (scientific journal)

Involvement of caspase 3-activated DNase in internucleasomal DNA cleavage induced by diverse apoptotic stimuli

McIlroy, D., Sakahira, H., Talanian, R.V., Nagata, S.

Oncogene　Vol. 18　No. 31　p. 4401-4408　1999　Research paper (scientific journal)

Fas ligand-induced apoptosis

Nagata, S.

Annual Review of Genetics　Vol. 33　p. 29-55　1999　Research paper (scientific journal)

Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease

Miwa, K., Hashimoto, H., Yatomi, T., Nakamura, N., Nagata, S., Suda, T.

International Immunology　Vol. 11　No. 6　p. 925-931　1999　Research paper (scientific journal)

Functional differences of two forms of the inhibitor of caspase- activated DNase, ICAD-L, and ICAD-S

Sakahira, H., Enari, M., Nagata, S.

Journal of Biological Chemistry　Vol. 274　No. 22　p. 15740-15744　1999　Research paper (scientific journal)

Apoptosis: Cell death defined by caspase activation [1]

Samali, A., Zhivotovsky, B., Jones, D., Nagata, S., Orrenius, S.

Cell Death and Differentiation　Vol. 6　No. 6　p. 495-496　1999　Research paper (scientific journal)

Structure and promoter analysis of murine CAD and ICAD genes

Kawane, K., Fukuyama, H., Adachi, M., Sakahira, H., Copeland, N.G., Gilbert, D.J., Jenkin, N.A., Nagata, S.

Cell Death and Differentiation　Vol. 6　No. 8　p. 745-752　1999　Research paper (scientific journal)

Interferon α augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression

Kaser, A., Nagata, S., Tilg, H.

Cytokine　Vol. 11　No. 10　p. 736-743　1999　Research paper (scientific journal)

Acute toxicity of an anti-Fas antibody in mice

Kakinuma, C., Takagaki, K., Yatomi, T., Nakamura, N., Nagata, S., Uemura, A., Shibutani, Y.

Toxicologic Pathology　Vol. 27　No. 4　p. 412-420　1999　Research paper (scientific journal)

Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus

Moriwaki, M., Itoh, N., Miyagawa, J., Yamamoto, K., Imagawa, A., Yamagata, K., Iwahashi, H., Nakajima, H., Namba, M., Nagata, S., Hanafusa, T., Matsuzawa, Y.

Diabetologia　Vol. 42　No. 11　p. 1332-1340　1999　Research paper (scientific journal)

The human caspase-activated dnase gene (hCAD): Genomic structure, exonic single-nucleotide polymorphisms, and a highly polymorphic dinucleotide repeat at the hCAD locus

Sugimoto, N., Fukuda, Y., Saito-Ohara, F., Kamiyama, R., Nakagawara, A., Mukae, N., Nagata, S., Inazawa, J.

Journal of Human Genetics　Vol. 44　No. 6　p. 408-411　1999　Research paper (scientific journal)

Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis

Kuwano, K., Hagimoto, N., Kawasaki, M., Yatomi, T., Nakamura, N., Nagata, S., Suda, T., Kunitake, R., Maeyama, T., Miyazaki, H., Hara, N.

Journal of Clinical Investigation　Vol. 104　No. 1　p. 13-19　1999　Research paper (scientific journal)

Molecular mechanism of apoptosis and its abnormality

Nagata Shigekazu

Shinzo　Vol. 30　No. 12　p. 777-784　1998

Myeloid-specific transcriptional activation by murine myeloid zinc- finger protein 2

Murai, K., Murakami, H., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 95　No. 7　p. 3461-3466　1998　Research paper (scientific journal)

Molecular cloning and characterization of human caspase-activated DNase

Mukae, N., Enari, M., Sakahira, H., Fukuda, Y., Inazawa, J., Toh, H., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 95　No. 16　p. 9123-9128　1998　Research paper (scientific journal)

High Fas ligand expression on lymphocytes in lesions of ulcerative colitis

Ueyama, H., Kiyohara, T., Sawada, N., Isozaki, K., Kitamura, S., Kondo, S., Miyagawa, J., Kanayama, S., Shinomura, Y., Ishikawa, H., Ohtani, T., Nezu, R., Nagata, S., Matsuzawa, Y.

Gut　Vol. 43　No. 1　p. 48-55　1998　Research paper (scientific journal)

Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond-Blackfan anemia

Hasegawa, D., Kojima, S., Tatsumi, E., Hayakawa, A., Kosaka, Y., Nakamura, H., Sako, M., Osugi, Y., Nagata, S., Sano, K.

Blood　Vol. 91　No. 8　p. 2793-2799　1998　Research paper (scientific journal)

Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice

Fukuyama, H., Adachi, M., Suematsu, S., Miwa, K., Suda, T., Yoshida, N., Nagata, S.

Journal of Immunology　Vol. 160　No. 8　p. 3805-3811　1998　Research paper (scientific journal)

Fas/FasL interaction is not involved in apoptosis of activated CD4⁺ T cells upon HIV-1 infection in vitro

Yagi, T., Sugimoto, A., Tanaka, M., Nagata, S., Yasuda, S., Yagita, H., Kuriyama, T., Takemori, T., Tsunetsugu-Yokota, Y.

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology　Vol. 18　No. 4　p. 307-315　1998　Research paper (scientific journal)

Fas-induced Apoptosis

S. Nagata

Internal Medicine　Vol. 37　No. 2　p. 179-181　1998　Research paper (scientific journal)

Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution

Samejima, K., Toné, S., Kottke, T.J., Enari, M., Sakahira, H., Cooke, C.A., Durrieu, F., Martins, L.M., Nagata, S., Kaufmann, S.H., Earnshaw, W.C.

Journal of Cell Biology　Vol. 143　No. 1　p. 225-239　1998　Research paper (scientific journal)

Caspase-independent cell killing by Fas-associated protein with death domain

Kawahara, A., Ohsawa, Y., Matsumura, H., Uchiyama, Y., Nagata, S.

Journal of Cell Biology　Vol. 143　No. 5　p. 1353-1360　1998　Research paper (scientific journal)

Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor

Kosai, K.-I., Matsumoto, K., Nagata, S., Tsujimoto, Y., Nakamura, T.

Biochemical and Biophysical Research Communications　Vol. 244　No. 3　p. 683-690　1998　Research paper (scientific journal)

Inhibition of Fas-induced apoptosis by Bcl-2

Kawahara, A., Kobayashi, T., Nagata, S.

Oncogene　Vol. 17　No. 20　p. 2549-2554　1998　Research paper (scientific journal)

Levels of soluble Fas ligand in myocarditis

Toyozaki, T., Hiroe, M., Tanaka, M., Nagata, S., Ohwada, H., Marumo, F.

American Journal of Cardiology　Vol. 82　No. 2　p. 246-248　1998　Research paper (scientific journal)

Downregulation of Fas ligand by shedding

Tanaka, M., Itai, T., Adachi, M., Nagata, S.

Nature Medicine　Vol. 4　No. 1　p. 31-36　1998　Research paper (scientific journal)

Fas-induced DNA fragmentation and proteolysis of nuclear proteins

Kawahara, A., Enari, M., Talanian, R.V., Wong, W.W., Nagata, S.

Genes to Cells　Vol. 3　No. 5　p. 297-306　1998　Research paper (scientific journal)

Soluble fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis

Hashimoto, H., Tanaka, M., Suda, T., Tomita, T., Hayashida, K., Takeuchi, E., Kaneko, M., Takano, H., Nagata, S., Ochi, T.

Arthritis and Rheumatism　Vol. 41　No. 4　p. 657-662　1998　Research paper (scientific journal)

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

Sakahira, H., Enari, M., Nagata, S.

Nature　Vol. 391　No. 6662　p. 96-99　1998　Research paper (scientific journal)

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., Nagata, S.

Nature　Vol. 391　No. 6662　p. 43-50　1998　Research paper (scientific journal)

Natural killer cell-derived large granular lymphocyte lymphoma of lung developed in a patient with hypersensitivity to mosquito bites and reactivated Epstein-Barr virus infection

Mizuki, M., Ueda, S., Tagawa, S., Shibayama, H., Nishimori, Y., Shibano, M., Asada, H., Tanaka, M., Nagata, S., Koudera, U., Suzuki, K., Machii, T., Ohsawa, M., Aozasa, K., Kitani, T., Kanakura, Y.

American Journal of Hematology　Vol. 59　No. 4　p. 309-315　1998　Research paper (scientific journal)

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: A lesson from the mouse model

Nagata, S.

Journal of Human Genetics　Vol. 43　No. 1　p. 2-8　1998　Research paper (scientific journal)

Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

Miwa, K., Asano, M., Horai, R., Iwakura, Y., Nagata, S., Suda, T.

Nature Medicine　Vol. 4　No. 11　p. 1287-1292　1998　Research paper (scientific journal)

Apoptosis and internal medicine diseases. Apoptosis.

Nihon Naika Gakkai Kaishi　Vol. 86　No. 9　p. 1579-1583　1997/09/10

Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6

S Ihara, K Nakajima, T Fukada, M Hibi, S Nagata, T Hirano, Y Fukui

EMBO JOURNAL　Vol. 16　No. 17　p. 5345-5352　1997/09　Research paper (scientific journal)

Elevated Serum Level of Fas Ligand Correlates With the Asymptomatic Stage of Human Immunodeficiency Virus Infection

George M. Bahr, Andre Capron, Joelle Dewulf, Shigekazu Nagata, Masato Tanaka, Jean-Michel Bourez, Yves Mouton

Blood　Vol. 90　No. 2　p. 896-898　1997/07/15　Research paper (scientific journal)

Apoptosis induced by a death factor

Nagata, S.

FASEB Journal　Vol. 11　No. 9　1997　Research paper (scientific journal)

Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells

Kondo, T., Yokokura, T., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 94　No. 22　p. 11951-11956　1997　Research paper (scientific journal)

Administration of IL-12 induces a CD3⁺CD4^-CD8^-B220⁺ lymphoid population capable of eliciting cytolysis against fas-positive tumor cells

Tsutsui, T., Mu, J., Ogawa, M., Yu, W.-G., Suda, T., Nagata, S., Saji, F., Murata, Y., Fujiwara, H., Hamaoka, T.

Journal of Immunology　Vol. 159　No. 6　p. 2599-2605　1997　Research paper (scientific journal)

Lack of Chronic Immune Activation in HIV-Infected Chimpanzees Correlates with the Resistance of T Cells to Fas/Apo-1 (CD95)-Induced Apoptosis and Preservation of a T Helper 1 Phenotype

Gougeon, M.-L., Lecoeur, H., Boudet, F., Ledru, E., Marzabal, S., Boullier, S., Roué, R., Nagata, S., Heeney, J.

Journal of Immunology　Vol. 158　No. 6　p. 2964-2976　1997　Research paper (scientific journal)

Why do defects in the Fas-Fas ligand system cause autoimmunity?

Suda, T., Nagata, S.

Journal of Allergy and Clinical Immunology　Vol. 100　No. 6 II　p. S97-S101　1997　Research paper (scientific journal)

Lethal Effect of Recombinant Human Fas Ligand in Mice Pretreated with Propionibacterium acnes

Tanaka, M., Suda, T., Yatomi, T., Nakamura, N., Nagata, S.

Journal of Immunology　Vol. 158　No. 5　p. 2303-2309　1997　Research paper (scientific journal)

Fas involvement in human NK cell apoptosis: Lack of a requirement for CD16-mediated events

Ortaldo, J.R., Winkler-Pickett, R.T., Nagata, S., Ware, C.F.

Journal of Leukocyte Biology　Vol. 61　No. 2　p. 209-215　1997　Research paper (scientific journal)

Molecular cloning and characterization of the chromosomal gene for human lactoperoxidase

Ueda, T., Sakamaki, K., Kuroki, T., Yano, I., Nagata, S.

European Journal of Biochemistry　Vol. 243　No. 1-2　p. 32-41　1997　Research paper (scientific journal)

Vasoactive intestinal polypeptide and pituitary adenylate cyclase- activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation

Hashimoto, H., Ogawa, N., Hagihara, N., Yamamoto, K., Imanishi, K., Nogi, H., Nishino, A., Fujita, T., Matsuda, T., Nagata, S., Baba, A.

Molecular Pharmacology　Vol. 52　No. 1　p. 128-135　1997　Research paper (scientific journal)

Transforming growth factor-β<inf>1</inf> abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells

Dybedal, I., Guan, F., Borge, O.J., Veiby, O.R., Ramsfjell, V., Nagata, S., Jacobsen, S.E.W.

Blood　Vol. 90　No. 9　p. 3395-3403　1997　Research paper (scientific journal)

Jak1 plays an essential role for receptor phosphorylation and stat activation in response to granulocyte colony-stimulating factor

Shimoda, K., Feng, J., Murakami, H., Nagata, S., Watling, D., Rogers, N.C., Stark, G.R., Kerr, I.M., Ihle, J.N.

Blood　Vol. 90　No. 2　p. 597-604　1997　Research paper (scientific journal)

Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury

Ertel, W., Keel, M., Stocker, R., Imhof, H.-G., Leist, M., Steckholzer, U., Tanaka, M., Trentz, O., Nagata, S.

Journal of Neuroimmunology　Vol. 80　No. 1-2　p. 93-96　1997　Research paper (scientific journal)

Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble fas ligand blocks the killing

Suda, T., Hashimoto, H., Tanaka, M., Ochi, T., Nagata, S.

Journal of Experimental Medicine　Vol. 186　No. 12　p. 2045-2050　1997　Research paper (scientific journal)

A novel form of the myeloid-specific zinc finger protein (MZF-2)

Murai, K., Murakami, H., Nagata, S., Nishikawa, S.-L.

Genes to Cells　Vol. 2　No. 9　p. 581-591　1997　Research paper (scientific journal)

Programmed cell death (apoptosis) in cord blood lymphocytes

Aggarwal, S., Gupta, A., Nagata, S., Gupta, S.

Journal of Clinical Immunology　Vol. 17　No. 1　p. 63-73　1997　Research paper (scientific journal)

Essential roles in the Fas ligand in the development of hepatitis

Kondo, T., Suda, T., Fukuyama, H., Adachi, M., Nagata, S.

Nature Medicine　Vol. 3　No. 4　p. 409-413　1997　Research paper (scientific journal)

Apoptosis by death factor

Nagata, S.

Cell　Vol. 88　No. 3　p. 355-365　1997　Research paper (scientific journal)

Induction of cell death by chimeric L-selectin-Fas receptors

Ishiwatari-Hayasaka, H., Kawashima, H., Osawa, T., Nagata, S., Miyasaka, M.

International Immunology　Vol. 9　No. 4　p. 627-635　1997　Research paper (scientific journal)

Involvement of STAT3 in the granulocyte colony-stimulating factor- induced differentiation of myeloid cells

Shimozaki, K., Nakajima, K., Hirano, T., Nagata, S.

Journal of Biological Chemistry　Vol. 272　No. 40　p. 25184-25189　1997　Research paper (scientific journal)

Binding of NF-Y transcription factor to one of the Cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor

Orita, T., Shimozaki, K., Murakami, H., Nagata, S.

Journal of Biological Chemistry　Vol. 272　No. 37　p. 23216-23223　1997　Research paper (scientific journal)

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

Itoh, N., Imagawa, A., Hanafusa, T., Waguri, M., Yamamoto, K., Iwahashi, H., Moriwaki, M., Nakajima, H., Miyagawa, J., Namba, M., Makino, S., Nagata, S., Kono, N., Matsuzawa, Y.

Journal of Experimental Medicine　Vol. 186　No. 4　p. 613-618　1997　Research paper (scientific journal)

No evidence for involvement of mouse protein-tyrosine phosphatase-BAS- like Fas-associated phosphatase-1 in Fas-mediated apoptosis

Cuppen, E., Nagata, S., Wieringa, B., Hendriks, W.

Journal of Biological Chemistry　Vol. 272　No. 48　p. 30215-30220　1997　Research paper (scientific journal)

Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus- infected cells

Xu, X.-N., Screaton, G.R., Gotch, F.M., Dong, T., Tan, R., Almond, N., Walker, B., Stebbings, R., Kent, K., Nagata, S., Stott, J.E., McMichael, A.J.

Journal of Experimental Medicine　Vol. 186　No. 1　p. 7-16　1997　Research paper (scientific journal)

ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis

Kondo, T., Takeuchi, K., Doi, Y., Yonemura, S., Nagata, S., Tsukita, S., Tsukita, S.

Journal of Cell Biology　Vol. 139　No. 3　p. 749-758　1997　Research paper (scientific journal)

Requirement for the CD95 receptor-ligand pathway in c-myc-induced apoptosis

Hueber, A.-O., Zörnig, M., Lyon, D., Suda, T., Nagata, S., Evan, G.I.

Science　Vol. 278　No. 5341　p. 1305-1309　1997　Research paper (scientific journal)

The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs

M{\"u}ller, W.E.G., Romero, F.J., Pergande, G., Perovic, S., Graeber, M.B., K{\"o}sel, S., Egensperger, R., Schnopp, N.M., Mehraein, P., Miura, M., Okada, M., Von Holst, A., Lefcort, F.B., Rodriguez-T{\'e}bar, A., Michaille, J.-J., Dhouailly, D., B{\"a}ckstr{\"o}m, A., Ebendal, T., Rohrer, H., Sendtner, M., Michaelidis, T., Gravel, C., G{\"o}tz, R., Ochs, G., Toyka, K.V., Thoenen, H., Egensperger, R., K{\"o}sel, S., Mehraein, P., Graeber, M.B., Homma, S., Oppenheim, R.W., Kwak, S., Heumann, R., Narz, F., Alg{\"u}r, Y., Bartsch, D., H{\"u}ser, M., Klinz, F.-J., Wagner, E., Berns, H., Obst, K., Wahle, P., Tanaka, H., Nakamura, M., Fukushima, M., Ohta, K., Jones, L.L., Banati, R.B., Raivich, G., Kreutzberg, G.W., Reiter, C., Nie, Z., Fischbach, K.-F., Eguchi, Y., Shimizu, S., Tsujimoto, Y., Davies, A.M., Adu, J., Middleton, G., Kuchino, Y., Kitanaka, C., Sugiyama, A., Asai, A., Gold, R., Hartung, H.-P., Matsuoka, I., Kobayashi, M., Fujii, M., Kurihara, K., Suda, T., Tanaka, M., Adachi, M., Nagata, S., Hattori, S., Matsuda, M., Nakamura, S., Hamanoue, M., Machide, M., Matsumoto, K., Nakamura, T., Nakajima, K., Kohsaka, S., Wanaka, A., Imaizumi, K., Tsuda, M., Imai, Y., Tohyama, M., Takagi, T., Barde, Y.-A., Mannherz, H.G., Rauch, F., Zanotti, S., Stephan, H., Paddenberg, R., Polzar, B., Engelmann, H., Hess, S., Gottfried, E.

Journal of Brain Research　Vol. 37　No. 4　1996　Research paper (scientific journal)

Enhanced and accelerated lymphoproliferation in Fas-null mice

Adachi, M., Suematsu, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T., Yoshida, N., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 93　No. 5　p. 2131-2136　1996　Research paper (scientific journal)

Apoptosis mediated by the Fas system.

Nagata, S.

Progress in molecular and subcellular biology　Vol. 16　p. 87-103　1996　Research paper (scientific journal)

Apoptosis of Mouse Naive T Cells Induced by Recombinant Soluble Fas Ligand and Activation-Induced Resistance to Fas Ligand

Suda, T., Tanaka, M., Miwa, K., Nagata, S.

Journal of Immunology　Vol. 157　No. 9　p. 3918-3924　1996　Research paper (scientific journal)

Apoptosis: Telling cells their time is up

Nagata, S.

Current Biology　Vol. 6　No. 10　p. 1241-1243　1996　Research paper (scientific journal)

Involvement of Fas Ligand and Fas-Mediated Pathway in the Cytotoxicity of Human Natural Killer Cells

Oshimi, Y., Oda, S., Honda, Y., Nagata, S., Miyazaki, S.

Journal of Immunology　Vol. 157　No. 7　p. 2909-2915　1996　Research paper (scientific journal)

Effects of myeloid cell growth factors on alkaline phosphatase, myeloperoxidase, defensin and granulocyte colony-stimulating factor receptor mRNA expression in haemopoietic cells of normal individuals and myeloid disorders

Tsuruta, T., Tani, K., Shimane, M., Ozawa, K., Takahashi, S., Tsuchimoto, D., Takahashi, K., Nagata, S., Sato, N., Asano, S.

British Journal of Haematology　Vol. 92　No. 1　p. 9-22　1996　Research paper (scientific journal)

Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle

Suzuki, A., Enari, M., Eguchi, Y., Matsuzawa, A., Nagata, S., Tsujimoto, Y., Iguchi, T.

EMBO Journal　Vol. 15　No. 2　p. 211-215　1996　Research paper (scientific journal)

Fas-mediated apoptosis of CD4⁺ and CD8⁺ T cells from human immunodeficiency virus-infected persons: Differential in vitro preventive effect of cytokines and protease antagonists

Estaquier, J., Tanaka, M., Suda, T., Nagata, S., Golstein, P., Ameisen, J.C.

Blood　Vol. 87　No. 12　p. 4959-4966　1996　Research paper (scientific journal)

Different apoptotic pathways mediated by Fas and the tumor-necrosis-factor receptor: Cytosolic phospholipase A<inf>2</inf> is not involved in Fas-mediated apoptosis

Enari, M., Hug, H., Hayakawa, M., Ito, F., Nishimura, Y., Nagata, S.

European Journal of Biochemistry　Vol. 236　No. 2　p. 533-538　1996　Research paper (scientific journal)

Fas-mediated apoptosis

Nagata, S.

Advances in Experimental Medicine and Biology　Vol. 406　p. 119-124　1996　Research paper (scientific journal)

Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo

Ehl, S., Hoffmann-Rohrer, U., Nagata, S., Hengartner, H., Zinkernagel, R.

Journal of Immunology　Vol. 156　No. 7　p. 2357-2360　1996　Research paper (scientific journal)

Distribution of the mRNA for a pituitary adenylate cyclase-activating polypeptide receptor in the rat brain: An in situ hybridization study

Hashimoto, H., Nogi, H., Mori, K., Ohishi, H., Shigemoto, R., Yamamoto, K., Matsuda, T., Mizuno, N., Nagata, S., Baba, A.

Journal of Comparative Neurology　Vol. 371　No. 4　p. 567-577　1996　Research paper (scientific journal)

Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: A role for Fc receptor coligation

Yamashita, Y., Miyake, K., Miura, Y., Kaneko, Y., Yagita, H., Suda, T., Nagata, S., Nomura, J., Sakaguchi, N., Kimoto, M.

Journal of Experimental Medicine　Vol. 184　No. 1　p. 113-120　1996　Research paper (scientific journal)

An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand

Sato, K., Kimura, F., Nakamura, Y., Murakami, H., Yoshida, M., Tanaka, M., Nagata, S., Kanatani, Y., Wakimoto, N., Nagata, N., Motoyoshi, K.

British Journal of Haematology　Vol. 94　No. 2　p. 379-382　1996　Research paper (scientific journal)

Fas ligand in human serum

Tanaka, M., Suda, T., Haze, K., Nakamura, N., Sato, K., Kimura, F., Motoyoshi, K., Mizuki, M., Tagawa, S., Ohga, S., Hatake, K., Drummond, A.H., Nagata, S.

Nature Medicine　Vol. 2　No. 3　p. 317-322　1996　Research paper (scientific journal)

A trial to kill tumor cells through Fas (CD95)-mediated apoptosis in vivo

Shimizu, M., Yoshimoto, T., Nagata, S., Matsuzawa, A.

Biochemical and Biophysical Research Communications　Vol. 228　No. 2　p. 375-379　1996　Research paper (scientific journal)

CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme

Teraoka, H., Yumoto, Y., Watanabe, F., Tsukada, K., Suwa, A., Enari, M., Nagata, S.

FEBS Letters　Vol. 393　No. 1　p. 1-6　1996　Research paper (scientific journal)

Cross-linking of Fas by antibodies to a peculiar domain of gp120 V3 loop can enhance T cell apoptosis in HIV-1-infected patients

Silvestris, F., Nagata, S., Cafforio, P., Silvestris, N., Dammacco, F.

Journal of Experimental Medicine　Vol. 184　No. 6　p. 2287-2300　1996　Research paper (scientific journal)

Fas-induced apoptosis, and diseases caused by its abnormality

Nagata, S.

Genes to Cells　Vol. 1　No. 10　p. 873-879　1996　Research paper (scientific journal)

Swapping between Fas and granulocyte colony-stimulating factor receptor

Takahashi, T., Tanaka, M., Ogasawara, J., Suda, T., Murakami, H., Nagata, S.

Journal of Biological Chemistry　Vol. 271　No. 29　p. 17555-17560　1996　Research paper (scientific journal)

Overexpression of Fas antigen on T cells in advanced HIV-1 infection: Differential ligation constantly induces apoptosis

Silvestris, F., Cafforio, P., Frassanito, M.A., Tucci, M., Romito, A., Nagata, S., Dammacco, F.

AIDS　Vol. 10　No. 2　p. 131-141　1996　Research paper (scientific journal)

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

Enari, M., Talanian, R.V., Wong, W.W., Nagata, S.

Nature　Vol. 380　No. 6576　p. 723-726　1996　Research paper (scientific journal)

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-fas antibody injection

Rodriguez, I., Matsuura, K., Khatib, K., Reed, J.C., Nagata, S., Vassalli, P.

Journal of Experimental Medicine　Vol. 183　No. 3　p. 1031-1036　1996　Research paper (scientific journal)

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death

Rodriguez, I., Matsuura, K., Ody, C., Nagata, S., Vassalli, P.

Journal of Experimental Medicine　Vol. 184　No. 5　p. 2067-2072　1996　Research paper (scientific journal)

Fas ligand and immune evasion

Nagata, S.

Nature Medicine　Vol. 2　No. 12　p. 1306-1307　1996　Research paper (scientific journal)

A possible involvement of Fas-Fas ligand signaling in the pathogenesis of murine autoimmune gastritis

Nishio, A., Katakai, T., Oshima, C., Kasakura, S., Sakai, M., Yonehara, S., Suda, T., Nagata, S., Masuda, T.

Gastroenterology　Vol. 111　No. 4　p. 959-967　1996　Research paper (scientific journal)

Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes

Redondo, C., Flores, I., Gonzalez, A., Nagata, S., Carrera, A.C., Merida, I., Martinez-A, C.

Journal of Clinical Investigation　Vol. 98　No. 5　p. 1245-1252　1996　Research paper (scientific journal)

EXPRESSION OF THE FAS LIGAND IN CELLS OF T-CELL LINEAGE

T SUDA, T OKAZAKI, Y NAITO, T YOKOTA, N ARAI, S OZAKI, K NAKAO, S NAGATA

JOURNAL OF IMMUNOLOGY　Vol. 154　No. 8　p. 3806-3813　1995/04　Research paper (scientific journal)

Pathways of tumour cell killing by activated macrophages: Both tumour cell membrane and nucleus can be the primary target

Keller, R., Keist, R., Groscurth, P., Hahn, S., Stalder, T., Schlegel, J., Kägi, D., Joller, P., Nagata, S., Erb, P.

Cell Death and Differentiation　Vol. 2　No. 2　p. 141-150　1995　Research paper (scientific journal)

Down‐modulation of CD4⁺ T helper type 2 and type 0 cells by T helper type 1 cells via Fas/Fasligand interaction

Hahn, S., Stalder, T., Wernli, M., Bürgin, D., Tschopp, J., Nagata, S., Erb, P.

European Journal of Immunology　Vol. 25　No. 9　p. 2679-2685　1995　Research paper (scientific journal)

Expression of the functional soluble form of human Fas ligand in activated lymphocytes

Tanaka, M., Suda, T., Takahashi, T., Nagata, S.

EMBO Journal　Vol. 14　No. 6　p. 1129-1135　1995　Research paper (scientific journal)

Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor

Yoshikawa, A., Murakami, H., Nagata, S.

EMBO Journal　Vol. 14　No. 21　p. 5288-5296　1995　Research paper (scientific journal)

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders

Watanabe, D., Suda, T., Hashimoto, H., Nagata, S.

EMBO Journal　Vol. 14　No. 1　p. 12-18　1995　Research paper (scientific journal)

Apoptosis by a cytosolic extract from Fas-activated cells

Enari, M., Hase, A., Nagata, S.

EMBO Journal　Vol. 14　No. 21　p. 5201-5208　1995　Research paper (scientific journal)

Expression of Fas in B cells of the mouse germinal center and fas-dependent killing of activated B cells

Watanabe, D., Suda, T., Nagata, S.

International Immunology　Vol. 7　No. 12　p. 1949-1956　1995　Research paper (scientific journal)

Overlapping and differential expression of BIG‐2, BIG‐1, TAG‐1, and F3: Four members of an axon‐associated cell adhesion molecule subgroup of the immunoglobulin superfamily

Yoshihara, Y., Kawasaki, M., Tamada, A., Nagata, S., Kagamiyama, H., Mori, K.

Journal of Neurobiology　Vol. 28　No. 1　p. 51-69　1995　Research paper (scientific journal)

Involvement of an ICE-like protease in Fas-mediated apoptosis

Enari, M., Hug, H., Nagata, S.

Nature　Vol. 375　No. 6526　p. 78-81　1995　Research paper (scientific journal)

Fas and Fas ligand: lpr and gld mutations

Nagata, S., Suda, T.

Immunology Today　Vol. 16　No. 1　p. 39-43　1995　Research paper (scientific journal)

The Fas Death Factor

Nagata, S., Golstein, P.

Science　Vol. 267　No. 5203　p. 1449-1456　1995　Research paper (scientific journal)

Tcr/cd3 coupling to fas-based cytotoxicity

Vignaux, F., Vivier, E., Malissen, B., Depraeter, V., Nagata, S., Golstein, P.

Journal of Experimental Medicine　Vol. 181　No. 2　p. 781-786　1995　Research paper (scientific journal)

Selective apoptosis of cd4⁺ cd8⁺ thymocytes by the anti-fas antibody

Ogasawara, J., Suda, T., Nagata, S.

Journal of Experimental Medicine　Vol. 181　No. 2　p. 485-491　1995　Research paper (scientific journal)

Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor

Aino, H., Hashimoto, H., Ogawa, N., Nishino, A., Yamamoto, K., Nogi, H., Nagata, S., Baba, A.

Gene　Vol. 164　No. 2　p. 301-304　1995　Research paper (scientific journal)

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

Adachi, M., Suematsu, S., Kondo, T., Ogasawara, J., Tanaka, T., Yoshida, N., Nagata, S.

Nature Genetics　Vol. 11　No. 3　p. 294-300　1995　Research paper (scientific journal)

教育講演 4 FAS、FASリガンドと免疫疾患

長田 重一

アレルギー　Vol. 43　No. 8　p. 955-955　1994

An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression

Yoshihara, Y., Oka, S., Nemoto, Y., Watanabe, Y., Nagata, S., Kagamiyama, H., Mori, K.

Neuron　Vol. 12　No. 3　p. 541-553　1994　Research paper (scientific journal)

Mutations in the Fas antigen gene in lpr mice

Nagata, S.

Seminars in Immunology　Vol. 6　No. 1　p. 3-8　1994　Research paper (scientific journal)

Functional characterization of the promoter for the gene encoding human eosinophil peroxidase

Yamaguchi, Y., Zhang, D.-E., Sun, Z., Albee, E.A., Nagata, S., Tenen, D.G., Ackerman, S.J.

Journal of Biological Chemistry　Vol. 269　No. 30　p. 19410-19419　1994　Research paper (scientific journal)

Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization

Watari, K., Ozawa, K., Tajika, K., Tojo, A., Tani, K., Asano, S., Kamachi, S.‐I., Harigaya, K., Takahashid, T., Sekiguchi, S., Nagata, S.

STEM CELLS　Vol. 12　No. 4　p. 416-423　1994　Research paper (scientific journal)

Defective T cells from gld mice play a pivotal role in development of Thy- 1.2⁺B220⁺ cells and autoimmunity

Yasutomo, K., Maeda, K.-I., Nagata, S., Nagasawa, H., Okada, K., Good, R.A., Kuroda, Y., Himeno, K.

Journal of Immunology　Vol. 153　No. 12　p. 5855-5864　1994　Research paper (scientific journal)

Clonal expansion but lack of subsequent clonal deletion of bacterial superantigen-reactive T cells in murine retroviral infection

Aoki, Y., Hiromatsu, K., Usami, J., Makino, M., Igarashi, H., Ogasawara, J., Nagata, S., Yoshikai, Y.

Journal of Immunology　Vol. 153　No. 8　p. 3611-3621　1994　Research paper (scientific journal)

Human fas ligand: Gene structure, chromosomal location and species specificity

Takahashi, T., Tanaka, M., Inazawa, J., Abe, T., Suda, T., Nagata, S.

International Immunology　Vol. 6　No. 10　p. 1567-1574　1994　Research paper (scientific journal)

Ligand binding domain of granulocyte colony-stimulating factor receptor

Hiraoka, O., Anaguchi, H., Yamasaki, K., Fukunaga, R., Nagata, S., Ota, Y.

Journal of Biological Chemistry　Vol. 269　No. 35　p. 22412-22419　1994　Research paper (scientific journal)

Characterization of the regulatory elements in the promoter of the human elongation factor-1α gene

Wakabayashi-Ito, N., Nagata, S.

Journal of Biological Chemistry　Vol. 269　No. 47　p. 29831-29837　1994　Research paper (scientific journal)

Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas.

Nagata, S.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences　Vol. 345　No. 1313　p. 281-287　1994　Research paper (scientific journal)

Fas and Fas Ligand: A Death Factor and Its Receptor

Nagata, S.

Advances in Immunology　Vol. 57　No. C　p. 129-144　1994　Research paper (scientific journal)

Lineage determination of CD7+ CD5− CD2− and CD7+ CD5+ CD2− lymphoblasts: Studies on phenotype, genotype, and gene expression of myeloperoxidase, CD3ϵ, and CD3δ

Yoneda, N., Tatsumi, E., Teshigawara, K., Nagata, S., Nagano, T., Kishimoto, Y., Kimura, T., Yasunaga, K., Yamaguchi, N.

American Journal of Hematology　Vol. 45　No. 4　p. 310-320　1994　Research paper (scientific journal)

Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes

Hashimoto, H., Aino, H., Ogawa, N., Nagata, S., Baba, A.

Biochemical and Biophysical Research Communications　Vol. 200　No. 2　p. 1042-1048　1994　Research paper (scientific journal)

Structural analysis of the functional gene and pseudogene encoding the murine granulocyte colony‐stimulating‐factor receptor

ITO, Y., SETO, Y., BRANNAN, C.I., COPELAND, N.G., JENKINS, N.A., FUKUNAGA, R., NAGATA, S.

European Journal of Biochemistry　Vol. 220　No. 3　p. 881-891　1994　Research paper (scientific journal)

Expression of granulocyte colony-stimulating factor and its receptor at the fetomaternal interface in murine and human pregnancy

Saito, S., Fukunaga, R., Ichijo, M., Nagata, S.

Growth Factors　Vol. 10　No. 2　p. 135-143　1994　Research paper (scientific journal)

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Takahashi, T., Tanaka, M., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Suda, T., Nagata, S.

Cell　Vol. 76　No. 6　p. 969-976　1994　Research paper (scientific journal)

BIG-1: A new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity

Yoshihara, Y., Kawasaki, M., Tani, A., Tamada, A., Nagata, S., Kagamiyama, H., Mori, K.

Neuron　Vol. 13　No. 2　p. 415-426　1994　Research paper (scientific journal)

Fas-mediated apoptosis in primary cultured mouse hepatocytes

Ni, R., Tomita, Y., Matsuda, K., Ichihara, A., Ishimura, K., Ogasawara, J., Nagata, S.

Experimental Cell Research　Vol. 215　No. 2　p. 332-337　1994　Research paper (scientific journal)

Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS

Hiromatsu, K., Aoki, Y., Makino, M., Matsumoto, Y., Mizuochi, T., Gotoh, Y., Nomoto, K., Ogasawara, J., Nagata, S., Yoshikai, Y.

European Journal of Immunology　Vol. 24　No. 10　p. 2446-2451　1994　Research paper (scientific journal)

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

Kägi, D., Vignaux, F., Ledermann, B., Bürki, K., Depraetere, V., Nagata, S., Hengartner, H., Golstein, P.

Science　Vol. 265　No. 5171　p. 528-530　1994　Research paper (scientific journal)

Purification and characterization of the fas-ligand that induces apoptosis

Suda, T., Nagata, S.

Journal of Experimental Medicine　Vol. 179　No. 3　p. 873-879　1994　Research paper (scientific journal)

No requirement of reactive oxygen intermediates in Fas-mediated apoptosis

Hug, H., Enari, M., Nagata, S.

FEBS Letters　Vol. 351　No. 3　p. 311-313　1994　Research paper (scientific journal)

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice

Adachi, M., Watanabe-Fukunaga, R., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 90　No. 5　p. 1756-1760　1993　Research paper (scientific journal)

Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor

Ishizaka-Ikeda, E., Fukunaga, R., Wood, W.I., Goeddel, D.V., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 90　No. 1　p. 123-127　1993　Research paper (scientific journal)

Unidirectional cross-phosphorylation between the granulocyte colony- stimulating factor and interleukin 3 receptors

Pan, C.-X., Fukunaga, R., Yonehara, S., Nagata, S.

Journal of Biological Chemistry　Vol. 268　No. 34　p. 25818-25823　1993　Research paper (scientific journal)

In vivo and in vitro suppression of primary B lymphocytopoiesis by tumor- derived and recombinant granulocyte colony-stimulating factor

Lee, M.Y., Fevold, K.L., Dorshkind, K., Fukunaga, R., Nagata, S., Rosse, C.

Blood　Vol. 82　No. 7　p. 2062-2068　1993　Research paper (scientific journal)

A novel protein domain required for apoptosis: Mutational analysis of human Fas antigen

Itoh, N., Nagata, S.

Journal of Biological Chemistry　Vol. 268　No. 15　p. 10932-10937　1993　Research paper (scientific journal)

Suppression of gene expression of myeloperoxidase (MPO) by γ-interferon (IFN-γ) in HL60 cells

Kawano, S., Tatsumi, E., Yoneda, N., Nagata, S., Yamaguchi, N.

Lymphokine and Cytokine Research　Vol. 12　No. 2　p. 81-85　1993　Research paper (scientific journal)

Effect of bcl-2 on Fas Antigen-Mediated Cell Death

Itoh, N., Tsujimoto, Y., Nagata, S.

Journal of Immunology　Vol. 151　No. 2　p. 621-627　1993　Research paper (scientific journal)

Granulocyte colony-stimulating factor receptor and its related receptors

Nagata, S., Fljkunaga, R.

Growth Factors　Vol. 8　No. 2　p. 99-107　1993　Research paper (scientific journal)

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

Fukunaga, R., Ishizaka-Ikeda, E., Nagata, S.

Cell　Vol. 74　No. 6　p. 1079-1087　1993　Research paper (scientific journal)

Identification of the product of the murine ST2 gene

Takagi, T., Yanagisawa, K., Tsukamoto, T., Tetsuka, T., Nagata, S., Tominaga, S.-i.

BBA - Molecular Cell Research　Vol. 1178　No. 2　p. 194-200　1993　Research paper (scientific journal)

Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide

Hashimoto, H., Ishihara, T., Shigemoto, R., Mori, K., Nagata, S.

Neuron　Vol. 11　No. 2　p. 333-342　1993　Research paper (scientific journal)

Lethal effect of the anti-Fas antibody in mice

Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., Nagata, S.

Nature　Vol. 364　No. 6440　p. 806-809　1993　Research paper (scientific journal)

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Suda, T., Takahashi, T., Golstein, P., Nagata, S.

Cell　Vol. 75　No. 6　p. 1169-1178　1993　Research paper (scientific journal)

2 SPECIES OF HUMAN CRK CDNA ENCODE PROTEINS WITH DISTINCT BIOLOGICAL-ACTIVITIES

M MATSUDA, S TANAKA, S NAGATA, A KOJIMA, T KURATA, M SHIBUYA

MOLECULAR AND CELLULAR BIOLOGY　Vol. 12　No. 8　p. 3482-3489　1992/08　Research paper (scientific journal)

Receptor for Granulocyte Colony-Stimulating Factor

S. Nagata, R. Fukunaga

Journal of Nutritional Science and Vitaminology　Vol. 38　p. 341-344　1992　Research paper (scientific journal)

Rational design of potent antagonists to the human growth hormone receptor

Fuh, G., Cunningham, B.C., Fukunaga, R., Nagata, S., Goeddel, D.V., Wells, J.A.

Science　Vol. 256　No. 5064　p. 1677-1680　1992　Research paper (scientific journal)

mRNA capping enzyme: Isolation and characterization of the gene encoding mRNA guanylyltransferase subunit from Saccharomyces cerevisiae

Shibagaki, Y., Itoh, N., Yamada, H., Nagata, S., Mizumoto, K.

Journal of Biological Chemistry　Vol. 267　No. 14　p. 9521-9528　1992　Research paper (scientific journal)

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen

Watanabe-Fukunaga, R., Brannan, C.I., Itoh, N., Yonehara, S., Copeland, N.G., Jenkins, N.A., Nagata, S.

Journal of Immunology　Vol. 148　No. 4　p. 1274-1279　1992　Research paper (scientific journal)

Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor

Seto, Y., Fukunaga, R., Nagata, S.

Journal of Immunology　Vol. 148　No. 1　p. 259-266　1992　Research paper (scientific journal)

Constitutive and inducible factors bind to regulatory element 3 in the promoter of the gene encoding mouse granulocyte colony-stimulating factor

Masahide, A., Shigekazu, N.

Gene　Vol. 121　No. 2　p. 371-375　1992　Research paper (scientific journal)

Hyperproduction of human interferon γ by rat cells maintained in low-serum medium using the fibronectin gene promoter

Nakajima, T., Tsunoda, S., Nakada, S., Nagata, S., Oda, K.

Journal of Biochemistry　Vol. 112　No. 5　p. 590-597　1992　Research paper (scientific journal)

cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein

Nishizawa, M., Nagata, S.

FEBS Letters　Vol. 299　No. 1　p. 36-38　1992　Research paper (scientific journal)

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., Nagata, S.

Nature　Vol. 356　No. 6367　p. 314-317　1992　Research paper (scientific journal)

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., Nagata, S.

Neuron　Vol. 8　No. 4　p. 811-819　1992　Research paper (scientific journal)

Assignment of the human fas antigen gene (FAS) to 10q24.1

Inazawa, J., Itoh, N., Abe, T., Nagata, S.

Genomics　Vol. 14　No. 3　p. 821-822　1992　Research paper (scientific journal)

Granulocyte colony-stimulating factor and its receptor

Nagata, S., Fukunaga, R.

Progress in Growth Factor Research　Vol. 3　No. 2　p. 131-141　1991　Research paper (scientific journal)

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., Nagata, S.

Cell　Vol. 66　No. 2　p. 233-243　1991　Research paper (scientific journal)

Constitutive production of granulocyte colony-stimulating factor by hybrids of a SV40-transformed mouse macrophage and a renal adenocarcinoma cell line

Ohki, K., Nagayama, A., Nagata, S.

Growth Factors　Vol. 5　No. 3　p. 183-189　1991　Research paper (scientific journal)

Bone modulation in sustained hematopoietic stimulation in mice

Lee, M.Y., Fukunaga, R., Lee, T.J., Lottsfeldt, J.L., Nagata, S.

Blood　Vol. 77　No. 10　p. 2135-2141　1991　Research paper (scientific journal)

Functional domains of the granulocyte colony-stimulating factor receptor

Fukunaga, R., Ishizaka-Ikeda, E., Pan, C.-X., Seto, Y., Nagata, S.

EMBO Journal　Vol. 10　No. 10　p. 2855-2865　1991　Research paper (scientific journal)

Molecular cloning and expression of a cDNA encoding the secretin receptor

Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T., Takahashi, K., Nagata, S.

EMBO Journal　Vol. 10　No. 7　p. 1635-1641　1991　Research paper (scientific journal)

Three individual regulatory elements of the promoter positively activate the transcription of the murine gene encoding granulocyte colony-stimulating factor

Asano, M., Nishizawa, M., Nagata, S.

Gene　Vol. 107　No. 2　p. 241-246　1991　Research paper (scientific journal)

Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3

Inazawa, J., Fukunaga, R., Seto, Y., Nakagawa, H., Misawa, S., Abe, T., Nagata, S.

Genomics　Vol. 10　No. 4　p. 1075-1078　1991　Research paper (scientific journal)

Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture

Kinashi, T., Lee, K.H., Ogawa, M., Tohyama, K., Tashiro, K., Fukunaga, R., Nagata, S., Honjo, T.

Journal of Experimental Medicine　Vol. 173　No. 5　p. 1267-1279　1991　Research paper (scientific journal)

Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1

Nishizawa, M., Wakabayashi-Ito, N., Nagata, S.

FEBS Letters　Vol. 282　No. 1　p. 95-97　1991　Research paper (scientific journal)

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor

Fukunaga, R., Seto, Y., Mizushima, S., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 87　No. 22　p. 8702-8706　1990　Research paper (scientific journal)

Expression of granulocyte and granulocyte-macrophage colony-stimulating factors by human non-hematopoietic tumor cells

Tani, K., Ozawa, K., Ogura, H., Shimane, M., Shirafuji, N., Tsuruta, T., Yokota, J., Nagata, S., Ueyama, Y., Takaku, F., Asano, S.

Growth Factors　Vol. 3　No. 4　p. 325-331　1990　Research paper (scientific journal)

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages

Nishizawa, M., Nagata, S.

Molecular and Cellular Biology　Vol. 10　No. 5　p. 2002-2011　1990　Research paper (scientific journal)

Multiple elements in the promoter of granulocyte colony-stimulating factor gene regulate its constitutive expression in human carcinoma cells

Nishizawa, M., Tsuchiya, M., Watanabe-Fukunaga, R., Nagata, S.

Journal of Biological Chemistry　Vol. 265　No. 10　p. 5897-5902　1990　Research paper (scientific journal)

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor

Fukunaga, R., Ishizaka-Ikeda, E., Nagata, S.

Journal of Biological Chemistry　Vol. 265　No. 23　p. 14008-14015　1990　Research paper (scientific journal)

Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to produce interferon-α

Shirafuji, N., Matsuda, S., Ogura, H., Tani, K., Kodo, H., Ozawa, K., Nagata, S., Asano, S., Takaku, F.

Blood　Vol. 75　No. 1　p. 17-19　1990　Research paper (scientific journal)

Implantation of Genetically Manipulated Fibroblasts into Mice as Antitumor α-Interferon Therapy

Ogura, H., Tani, K., Ozawa, K., Asano, S., Takaku, F., Nagata, S.

Cancer Research　Vol. 50　No. 16　p. 5102-5106　1990　Research paper (scientific journal)

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., Nagata, S.

Nucleic Acids Research　Vol. 18　No. 17　p. 5322-5322　1990　Research paper (scientific journal)

Vargula hilgendorfii luciferase: a secreted reporter enzyme for monitoring gene expression in mammalian cells

Thompson, E.M., Nagata, S., Tsuji, F.I.

Gene　Vol. 96　No. 2　p. 257-262　1990　Research paper (scientific journal)

Expression cloning of a receptor for murine granulocyte colony-stimulating factor

Fukunaga, R., Ishizaka-Ikeda, E., Seto, Y., Nagata, S.

Cell　Vol. 61　No. 2　p. 341-350　1990　Research paper (scientific journal)

A new bioassay for human granulocyte colony-stimulating factor (hG-CSF) using murine myeloblastic NFS-60 cells as targets and estimation of its levels in sera from normal healthy persons and patients with infectious and hematological disorders.

Shirafuji N, Asano S, Matsuda S, Watari K, Takaku F, Nagata S

Journal of Biological Chemistry　Vol. 17　No. 2　p. 116-119　1989/02　Research paper (scientific journal)

Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase

Sakamaki, K., Tomonaga, M., Tsukui, K., Nagata, S.

Journal of Biological Chemistry　Vol. 264　No. 28　p. 16828-16836　1989　Research paper (scientific journal)

Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii

Thompson, E.M., Nagata, S., Tsuji, F.I.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 86　No. 17　p. 6567-6571　1989　Research paper (scientific journal)

Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1α

Uetsuki, T., Naito, A., Nagata, S., Kaziro, Y.

Journal of Biological Chemistry　Vol. 264　No. 10　p. 5791-5798　1989　Research paper (scientific journal)

Synthesis and localization of myeloperoxidase protein in transfected BHK cells

Cully, J., Harrach, B., Hauser, H., Harth, N., Robenek, H., Nagata, S., Hasilik, A.

Experimental Cell Research　Vol. 180　No. 2　p. 440-450　1989　Research paper (scientific journal)

A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human

Buchberg, A.M., Brownell, E., Nagata, S., Jenkins, N.A., Copeland, N.G.

Genetics　Vol. 122　No. 1　p. 153-161　1989　Research paper (scientific journal)

A new bioassay for human granulocyte colony-stimulating factor (hG-CSF) using murine myeloblastic NFS-60 cells as targets and estimation of its levels in sera from normal healthy persons and patients with infectious and hematological disorders

Shirafuji, N., Asano, S., Matsuda, S., Watari, K., Takaku, F., Nagata, S.

Experimental Hematology　Vol. 17　No. 2　p. 116-119　1989　Research paper (scientific journal)

Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy

Tani, K., Ozawa, K., Ogura, H., Takahashi, T., Akano, A., Watari, K., Matsudaira, T., Tajika, K., Karasuyama, H., Nagata, S., Asano, S., Takaku, F.

Blood　Vol. 74　No. 4　p. 1274-1280　1989　Research paper (scientific journal)

Human liver type pyruvate kinase: Complete amino acid sequence and the expression in mammalian cells

Tani, K., Fujii, H., Nagata, S., Miwa, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 85　No. 6　p. 1792-1795　1988　Research paper (scientific journal)

Localization of Evi-2 to chromosome 11: Linkage to other proto-oncogene and growth factor loci using interspecific backcross mice

Buchberg, A.M., Bedigian, H.G., Taylor, B.A., Brownell, E., Ihle, J.N., Nagata, S., Jenkins, N.A., Copeland, N.G.

Oncogene Research　Vol. 2　No. 2　p. 149-165　1988　Research paper (scientific journal)

Bipotential murine hemopoietic cell line (NFS-60) that is responsive to IL-3, GM-CSF, G-CSF, and erythropoietin

Hara, K., Suda, T., Suda, J., Eguchi, M., Ihle, J.N., Nagata, S., Miura, Y., Saito, M.

Experimental Hematology　Vol. 16　No. 4　p. 256-261　1988　Research paper (scientific journal)

Production of granulocyte colony-stimulating factor by acute myelomonocytic leukemia cells

Shirafuji, N., Asano, S., Kozai, K., Takahashi, S., Matsuda, S., Takaku, F., Nagata, S.

Leukemia Research　Vol. 12　No. 9　p. 745-750　1988　Research paper (scientific journal)

Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells.

Tsuchiya, M., Nomura, H., Asano, S., Kaziro, Y., Nagata, S.

EMBO Journal　Vol. 6　No. 3　p. 611-616　1987　Research paper (scientific journal)

Effects of recombinant murine granulocyte colony-stimulating factor on granulocyte-macrophage and blast colony formation

Suda, T., Suda, J., Kajigaya, S., Nagata, S., Asano, S., Saito, M., Miura, Y.

Experimental Hematology　Vol. 15　No. 9　p. 958-965　1987　Research paper (scientific journal)

cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA thiolase with no transient presequence: structural relationship with peroxisomal isozyme.

Arakawa, H., Takiguchi, M., Amaya, Y., Nagata, S., Hayashi, H., Mori, M.

EMBO Journal　Vol. 6　No. 5　p. 1361-1366　1987　Research paper (scientific journal)

Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor

Morishita, K., Tsuchiya, M., Asano, S., Kaziro, Y., Nagata, S.

Journal of Biological Chemistry　Vol. 262　No. 31　p. 15208-15213　1987　Research paper (scientific journal)

Molecular cloning and characterization of cDNA for human myeloperoxidase

Morishita, K., Kubota, N., Asano, S., Kaziro, Y., Nagata, S.

Journal of Biological Chemistry　Vol. 262　No. 8　p. 3844-3851　1987　Research paper (scientific journal)

Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17

Kanda, N., Fukushige, S.-i., Murotsu, T., Yoshida, M.C., Tsuchiya, M., Asano, S., Kaziro, Y., Nagata, S.

Somatic Cell and Molecular Genetics　Vol. 13　No. 6　p. 679-684　1987　Research paper (scientific journal)

The chromosomal gene structure for murine granulocyte colony‐stimulating factor

TSUCHIYA, M., KAZIRO, Y., NAGATA, S.

European Journal of Biochemistry　Vol. 165　No. 1　p. 7-12　1987　Research paper (scientific journal)

Induction of neutrophilic granulocytosis in mice by administration of purified human native granulocyte colony-stimulating factor (G-CSF)

Tamura, M., Hattori, K., Nomura, H., Oheda, M., Kubota, N., Imazeki, I., Ono, M., Ueyama, Y., Nagata, S., Shirafuji, N., Asano, S.

Biochemical and Biophysical Research Communications　Vol. 142　No. 2　p. 454-460　1987　Research paper (scientific journal)

The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.

S. Nagata, M. Tsuchiya, S. Asano, O. Yamamoto, Y. Hirata, N. Kubota, M. Oheda, H. Nomura, T. Yamazaki

The EMBO Journal　Vol. 5　No. 3　p. 575-581　1986/03　Research paper (scientific journal)

Molecular cloning and sequence determination of cDNAs for α subunits of the guanine nucleotide-binding proteins G(s), G(i) and G(o) from rat brain

Itoh, H., Kozasa, T., Nagata, S., Nakamura, S., Katada, T., Ui, M., Iwai, S., Ohtsuka, E., Kawasaki, H., Suzuki, K.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 83　No. 11　p. 3776-3780　1986　Research paper (scientific journal)

Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor

Tsuchiya, M., Asano, S., Kaziro, Y., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 83　No. 20　p. 7633-7637　1986　Research paper (scientific journal)

Structure of the two genes coding for polypeptide chain elongation factor lα (EF-lα) froni Saccharomyces cerevisiae

Koji, N., Masataka, K., Shigekazu, N., Yoshito, K.

Gene　Vol. 45　No. 3　p. 265-273　1986　Research paper (scientific journal)

2 MONOCLONAL-ANTIBODIES DISTINGUISH BETWEEN HUMAN RECOMBINANT INTERFERON-ALPHA-5S PRODUCED BY ESCHERICHIA-COLI AND BY MOUSE CELLS

K TSUKUI, R FUKUNAGA, S NAGATA, K ITO

MICROBIOLOGY AND IMMUNOLOGY　Vol. 30　No. 12　p. 1271-1279　1986　Research paper (scientific journal)

Uudermethylation of interferon-γ gene in human T cell lines and normal T lymphocytes

Fukunaga, R., Matsuyama, M., Okamura, H., Nagata, K., Nagata, S., Sokawa, Y.

Nucleic Acids Research　Vol. 14　No. 11　p. 4421-4436　1986　Research paper (scientific journal)

Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor

Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., Ono, M.

Nature　Vol. 319　No. 6052　p. 415-418　1986　Research paper (scientific journal)

Structural relationship of human interferon alpha genes and pseudogenes

Henco, K., Brosius, J., Fujisawa, A., Fujisawa, J.-I., Haynes, J.R., Hochstadt, J., Kovacic, T., Pasek, M., Schamböck, A., Schmid, J., Todokoro, K., Wälchli, M., Nagata, S., Weissmann, C.

Journal of Molecular Biology　Vol. 185　No. 2　p. 227-260　1985　Research paper (scientific journal)

Molecular cloning and nucleotide sequence of cDNA for rat ornithine carbamoyltransferase precursor

Takiguchi, M., Miura, S., Mori, M., Tatibana, M., Nagata, S., Kaziro, Y.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 81　No. 23 I　p. 7412-7416　1984　Research paper (scientific journal)

Constitutive production of human interferons by mouse cells with bovine papillomavirus as a vector

Fukunaga, R., Sokawa, Y., Nagata, S.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 81　No. 16 I　p. 5086-5090　1984　Research paper (scientific journal)

Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae.

Nagata, S., Nagashima, K., Tsunetsugu-Yokota, Y., Fujimura, K., Miyazaki, M., Kaziro, Y.

EMBO Journal　Vol. 3　No. 8　p. 1825-1830　1984　Research paper (scientific journal)

Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae.

Nagata, S., Tsunetsugu-Yokota, Y., Naito, A., Kaziro, Y.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 80　No. 20　p. 6192-6196　1983　Research paper (scientific journal)

Different binding of human interferon α1 and α2 to common receptors on human and bovine cells. Studies with recombinant interferons produced in Escherichia coli

Yonehara, S., Yonehara Takahashi, M., Ishii, A., Nagata, S.

Journal of Biological Chemistry　Vol. 258　No. 15　p. 9046-9049　1983　Research paper (scientific journal)

Structure and expression of human alpha-interferon genes.

Weismann, C., Nagata, S., Boll, S., Fountoulakis, M., Fujisawa, A., Fujisawa, J., Haynes, J., Henco, K., Mantei, N., Ragg, H.

Princess Takamatsu symposia　Vol. 12　1982　Research paper (scientific journal)

Structure and expression of human IFN-alpha genes.

Weissmann, C., Nagata, S., Boll, W., Fountoulakis, M., Fujisawa, A., Fujisawa, J.I., Haynes, J., Henco, K., Mantei, N., Ragg, H., Schein, C., Schmid, J., Shaw, G., Streuli, M., Taira, H., Todokoro, K., Weidle, U.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences　Vol. 299　No. 1094　p. 7-28　1982　Research paper (scientific journal)

Chromosomal location of a human α interferon gene family

Slate, D.L., D'Eustachio, P., Pravtcheva, D., Cunningham, A.C., Nagata, S., Weissmann, C., Ruddle, F.H.

Journal of Experimental Medicine　Vol. 155　No. 4　p. 1019-1024　1982　Research paper (scientific journal)

Target cell specificity of two species of human interferon-α produced in Escherichia coli and of hybrid molecules derived from them

Streuli, M., Hall, A., Boll, W., Stewart, W.I., Nagata, S., Weissmann, C., Stewart II, W.E.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 78　No. 5 I　p. 2848-2852　1981　Research paper (scientific journal)

Partial Mapping of Ten Genes of the Human Interferon- α Family

Nagata, S., Brack, C., Henco, K., Schamböck, A., Weissmann, C.

Journal of Interferon Research　Vol. 1　No. 2　p. 333-336　1981　Research paper (scientific journal)

Comparative antiviral efficiency of leukocyte and bacterially produced human α-interferon in rhesus monkeys

Schellekens, H., De Reus, A., Bolhuis, R., Fountoulakis, M., Schein, C., Ecsödi, J., Nagata, S., Weissmann, C.

Nature　Vol. 292　No. 5825　p. 775-776　1981　Research paper (scientific journal)

Molecular analysis of the human interferon-α gene family

Brack, C., Nagata, S., Mantei, N., Weissmann, C.

Gene　Vol. 15　No. 4　p. 379-394　1981　Research paper (scientific journal)

At least three human type α interferons: Structure of α2

Streuli, M., Nagata, S., Weissmann, C.

Science　Vol. 209　No. 4463　p. 1343-1347　1980　Research paper (scientific journal)

Human leukocyte and fibroblast interferons are structurally related

Taniguchi, T., Mantei, N., Schwarzstein, M., Nagata, S., Muramatsu, M., Weissmann, C.

Nature　Vol. 285　No. 5766　p. 547-549　1980　Research paper (scientific journal)

Comparisons of several biological and physicochemical properties of human leukocyte interferons produced by human leukocytes and by E. coli

Stewart, W.E., Sarkar, F.H., Taira, H., Hall, A., Shigekazu, N., Weissmann, C.

Gene　Vol. 11　No. 3-4　p. 181-186　1980　Research paper (scientific journal)

Synthesis in E. coli of a polypeptide with human leukocyte interferon activity

Nagata, S., Taira, H., Hall, A., Johnsrud, L., Streuli, M., Ecsödi, J., Boll, W., Cantell, K., Weissmann, C.

Nature　Vol. 284　No. 5754　p. 316-320　1980　Research paper (scientific journal)

Effect of interferon-α1 from E. coli on some sell functions

Masucci, M.G., Szigeti, R., Klein, E., Klein, G., Gruest, J., Montagnier, L., Taira, H., Hall, A., Nagata, S., Weissmann, C.

Science　Vol. 209　No. 4463　p. 1431-1435　1980　Research paper (scientific journal)

The structure of one of the eight or more distinct chromosomal genes for human interferon-α

Nagata, S., Mantei, N., Weissmann, C.

Nature　Vol. 287　No. 5781　p. 401-408　1980　Research paper (scientific journal)

The nucleotide sequence of a cloned human leukocyte Interferon cDNA

Mantei, N., Schwarzstein, M., Streuli, M., Panem, S., Nagata, S., Weissmann, C.

Gene　Vol. 10　No. 1　p. 1-10　1980　Research paper (scientific journal)

Interaction of subunits of polypeptide chain elongation factor 1 from pig liver: Formation of ef-1α.ef-1βγ and ef-lα-ef-1β complexes

Nagata, S., Motoyoshi, K., Iwasaki, K.

Journal of Biochemistry　Vol. 83　No. 2　p. 423-429　1978　Research paper (scientific journal)

Purification and properties of polypeptide chain elongation factor-lα from pig liver

Nagata, S., Iwasaki, K., Kaziro, Y.

Journal of Biochemistry　Vol. 82　No. 6　p. 1633-1646　1977　Research paper (scientific journal)

Purification and properties of a new polypeptide chain elongation factor, EF 1β, from pig liver

Iwasaki, K., Motoyoshi, K., Nagata, S., Kaziro, Y.

Journal of Biological Chemistry　Vol. 251　No. 6　p. 1843-1845　1976　Research paper (scientific journal)

Interaction of the low molecular weight form of elongation factor 1 with guanine nucleotides and aminoacyl-tRNA

Nagata, S., Iwasaki, K., Kaziro, Y.

Archives of Biochemistry and Biophysics　Vol. 172　No. 1　p. 168-177　1976　Research paper (scientific journal)

Distribution of the low molecular weight form of eukaryotic elongation factor 1 in various tissues

Nagata, S., Iwasaki, K., Kaziro, Y.

Journal of Biochemistry　Vol. 80　No. 1　p. 73-77　1976　Research paper (scientific journal)

Exchange of free GTP with EF-1α·GDP complex promoted by a factor EF-1β from pig liver

Nagata, S., Motoyoshi, K., Iwasaki, K.

Biochemical and Biophysical Research Communications　Vol. 71　No. 4　p. 933-938　1976　Research paper (scientific journal)

The purification of low molecular weight form of polypeptide elongation factor 1 from pig liver

Iwasaki, K., Nagata, S., Mizumoto, K., Kaziro, Y.

Journal of Biological Chemistry　Vol. 249　No. 15　p. 5008-5010　1974　Research paper (scientific journal)