Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation.

Yuji Goto, Kichitaro Nakajima, Suguru Yamamoto, Keiichi Yamaguchi

Journal of molecular biology　p. 168475-168475　2024/02/02　Research paper (scientific journal)

Thermodynamic stability of human lipocalin-type prostaglandin D synthase under various pH conditions.

Tsukimi Iida, Masatoshi Nakatsuji, Yoshiaki Teraoka, Yuji Goto, Takaki Yamamura, Takashi Inui

Journal of biochemistry　Vol. 174　No. 1　p. 21-31　2023/06/30　Research paper (scientific journal)

Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor

Lianjie Zhou, Touko Hajiri, Kichitaro Nakajima, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Keiichi Yamaguchi, Yuji Goto, Hirotsugu Ogi

ACS Sensors　2023/06/26　Research paper (scientific journal)

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism

Chi Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed, Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

ACTA NEUROPATHOLOGICA　Vol. 145　No. 5　p. 573-595　2023/03　Research paper (scientific journal)

Mechanisms of polyphosphate-induced amyloid fibril formation triggered by breakdown of supersaturation

Keiichi Yamaguchi, Kichitaro Nakajima, Yuji Goto

Biophysics and Physicobiology　Vol. 20　No. 1　p. n/a-n/a　2023　Research paper (scientific journal)

Supersaturation-Dependent Formation of Amyloid Fibrils

Yuji Goto, Masahiro Noji, Kichitaro Nakajima, Keiichi Yamaguchi

Molecules　Vol. 27　No. 14　p. 4588-4588　2022/07/19　Research paper (scientific journal)

Pathway Dependence of the Formation and Development of Prefibrillar Aggregates in Insulin B Chain

Yuki Yoshikawa, Keisuke Yuzu, Naoki Yamamoto, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Tetsushi Iwasaki, Masatomo So, Yuji Goto, Atsuo Tamura, Eri Chatani

Molecules　Vol. 27　No. 13　p. 3964-3964　2022/06/21　Research paper (scientific journal)

Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs

Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki

bioRxiv　2022/02/10　Research paper (scientific journal)

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto

2022/02/04

Development of HANABI, an ultrasonication-forced amyloid fibril inducer

Yuji Goto, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi

Neurochemistry International　Vol. 153　p. 105270-105270　2022/02　Research paper (scientific journal)

Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.

Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

Scientific reports　Vol. 12　No. 1　p. 351-351　2022/01/10　Research paper (scientific journal)

Acceleration of amyloid fibril formation by multichannel sonochemical reactor

Kentaro Noi, Kichitaro Nakajima, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu OGI

Japanese Journal of Applied Physics　2021/12/08　Research paper (scientific journal)

Strong acids induce amyloid fibril formation of β2-microglobulin via an anion-binding mechanism

Keiichi Yamaguchi, Kenshiro Hasuo, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto

Journal of Biological Chemistry　Vol. 297　No. 5　p. 101286-101286　2021/11　Research paper (scientific journal)

Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction

Kichitaro Nakajima, Hajime Toda, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi

ACS Chemical Neuroscience　Vol. 12　No. 18　p. 3456-3466　2021/09/15　Research paper (scientific journal)

Disaggregation Behavior of Amyloid β Fibrils by Anthocyanins Studied by Total-Internal-Reflection-Fluorescence Microscopy Coupled with a Wireless Quartz-Crystal Microbalance Biosensor

Kentaro Noi, Kensuke Ikenaka, Hideki Mochizuki, Yuji Goto, Hirotsugu Ogi

Analytical Chemistry　2021/08/05　Research paper (scientific journal)

pHによるウレミックトキシンの蛋白結合能の変化

山本 卓, 山口 圭一, 土門 美緒, 伊藤 徹, 後藤 眞, 後藤 祐児, 成田 一衛

日本腎臓学会誌　Vol. 63　No. 4　p. 481-481　2021/06

Polyphenol-solubility alters amyloid fibril formation of α-synuclein.

Masatomo So, Yuto Kimura, Keiichi Yamaguchi, Toshihiko Sugiki, Toshimichi Fujiwara, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto

Protein science : a publication of the Protein Society　Vol. 30　No. 8　p. 1701-1713　2021/05/27　Research paper (scientific journal)

Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation

Kichitaro Nakajima, Kentaro Noi, Keiichi Yamaguchi, Masatomo So, Kensuke Ikenaka, Hideki Mochizuki, Hirotsugu Ogi, Yuji Goto

Ultrasonics Sonochemistry　Vol. 73　p. 105508-105508　2021/05　Research paper (scientific journal)

Current Understanding of the Structure, Stability and Dynamic Properties of Amyloid Fibrils.

Eri Chatani, Keisuke Yuzu, Yumiko Ohhashi, Yuji Goto

International journal of molecular sciences　Vol. 22　No. 9　2021/04/21　Research paper (scientific journal)

Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners.

Keiichi Yamaguchi, Masatomo So, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto

The Journal of biological chemistry　p. 100510-100510　2021/03/04　Research paper (scientific journal)

pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro.

Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita

Toxins　Vol. 13　No. 2　2021/02/04　Research paper (scientific journal)

Multistep Changes in Amyloid Structure Induced by Cross-Seeding on a Rugged Energy Landscape.

Keisuke Yuzu, Naoki Yamamoto, Masahiro Noji, Masatomo So, Yuji Goto, Tetsushi Iwasaki, Motonari Tsubaki, Eri Chatani

Biophysical journal　Vol. 120　No. 2　p. 284-295　2021/01/19　Research paper (scientific journal)

Breakdown of supersaturation barrier links protein folding to amyloid formation

Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto

Communications Biology　Vol. 4　No. 120　2021/01　Research paper (scientific journal)

光技術の認知症研究への応用の可能性 放射光を用いたレビー小体の微細構造解析

荒木 克哉, 八木 直人, 永井 義隆, 後藤 祐児, 望月 秀樹

Dementia Japan　Vol. 34　No. 4　p. 464-464　2020/10

Dialysis-related amyloidosis associated with a novel β2-microglobulin variant.

Hiroki Mizuno, Junichi Hoshino, Masatomo So, Yuta Kogure, Takeshi Fujii, Yoshifumi Ubara, Kenmei Takaichi, Tetsuko Nakaniwa, Hideaki Tanaka, Genji Kurisu, Fuyuki Kametani, Mayuko Nakagawa, Tsuneaki Yoshinaga, Yoshiki Sekijima, Keiichi Higuchi, Yuji Goto, Masahide Yazaki

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis　Vol. 28　No. 1　p. 1-8　2020/09/02　Research paper (scientific journal)

Time-Resolved Observation of Evolution of Amyloid-β Oligomer with Temporary Salt Crystals.

Kichitaro Nakajima, Tomoya Yamazaki, Yuki Kimura, Masatomo So, Yuji Goto, Hirotsugu Ogi

The journal of physical chemistry letters　Vol. 11　No. 15　p. 6176-6184　2020/08/06　Research paper (scientific journal)

Distinct residual and disordered structures of alpha-synuclein analyzed by amide-proton exchange and NMR signal intensity.

Rina Okuwaki, Iori Shinmura, Shiki Morita, Akimasa Matsugami, Fumiaki Hayashi, Yuji Goto, Chiaki Nishimura

Biochimica et biophysica acta. Proteins and proteomics　p. 140464-140464　2020/06/01　Research paper (scientific journal)

Amyloid Formation of α-Synuclein Based on the Solubility- and Supersaturation-Dependent Mechanism

Maya Sawada, Keiichi Yamaguchi, Miki Hirano, Masahiro Noji, Masatomo So, Daniel Otzen, Yasushi Kawata, Yuji Goto

Langmuir　Vol. 36　No. 17　p. 4671-4681　2020/05/05　Research paper (scientific journal)

Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism

Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Yasushi Kawata, Yuji Goto

Current Research in Structural Biology　Vol. 2　p. 35-44　2020/04/05　Research paper (scientific journal)

Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response

Toru Ito, Suguru Yamamoto, Keiichi Yamaguchi, Mami Sato, Yoshikatsu Kaneko, Shin Goto, Yuji Goto, Ichiei Narita

Journal of Biological Chemistry　Vol. 295　No. 12　p. 4014-4023　2020/03/20　Research paper (scientific journal)

The Route from the Folded to the Amyloid State: Exploring the Potential Energy Surface of a Drug-Like Miniprotein.

Nóra Taricska, Dániel Horváth, Dóra K Menyhárd, Hanna Ákontz-Kiss, Masahiro Noji, Masatomo So, Yuji Goto, Toshimichi Fujiwara, András Perczel

Chemistry (Weinheim an der Bergstrasse, Germany)　Vol. 26　No. 9　p. 1893-1893　2020/02/11　Research paper (scientific journal)

Amyloid Formation under Complicated Conditions in Which β2-Microglobulin Coexists with Its Proteolytic Fragments

Hiroya Muta, Masatomo So, Kazumasa Sakurai, Jozsef Kardos, Hironobu Naiki, Yuji Goto

Biochemistry　2019/11　Research paper (scientific journal)

Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation

Kenji Sasahara, Keiichi Yamaguchi, Masatomo So, Yuji Goto

Journal of Biological Chemistry　Vol. 294　No. 42　p. 15318-15329　2019/10　Research paper (scientific journal)

Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein.

Katsuya Araki, Naoto Yagi, Koki Aoyama, Chi-Jing Choong, Hideki Hayakawa, Harutoshi Fujimura, Yoshitaka Nagai, Yuji Goto, Hideki Mochizuki

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 36　p. 17963-17969　2019/09/03

Heating during agitation of β2-microglobulin reveals that supersaturation breakdown is required for amyloid fibril formation at neutral pH.

Noji M, Sasahara K, Yamaguchi K, So M, Sakurai K, Kardos J, Naiki H, Goto Y

The Journal of biological chemistry　Vol. in press　2019/09　Research paper (scientific journal)

Possible mechanisms of polyphosphate-induced amyloid fibril formation of β₂-microglobulin.

Zhang CM, Yamaguchi K, So M, Sasahara K, Ito T, Yamamoto S, Narita I, Kardos J, Naiki H, Goto Y

Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 26　p. 12833-12838　2019/06　Research paper (scientific journal)

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.

Keita Kakuda, Kensuke Ikenaka, Katsuya Araki, Masatomo So, César Aguirre, Yuta Kajiyama, Kuni Konaka, Kentaro Noi, Kousuke Baba, Hiroshi Tsuda, Seiichi Nagano, Takuma Ohmichi, Yoshitaka Nagai, Takahiko Tokuda, Omar M A El-Agnaf, Hirotsugu Ogi, Yuji Goto, Hideki Mochizuki

Scientific reports　Vol. 9　No. 1　p. 6001-6001　2019/04/12　Research paper (scientific journal)

A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia.

Kakuda K, Niwa A, Honda R, Yamaguchi KI, Tomita H, Nojebuzzaman M, Hara A, Goto Y, Osawa M, Kuwata K

Journal of biochemistry　Vol. 165　No. 4　p. 369-378　2019/04　Research paper (scientific journal)

The Route from the Folded to the Amyloid State: Exploring the Potential Energy Surface of a Drug-Like Miniprotein

Nóra Taricska, Dániel Horváth, Dóra K. Menyhárd, Hanna Ákontz-Kiss, Masahiro Noji, Masatomo So, Yuji Goto, Toshimichi Fujiwara, András Perczel

Chemistry - A European Journal　2019　Research paper (scientific journal)

Aggregation-phase diagrams of β₂-microglobulin reveal temperature and salt effects on competitive formation of amyloids versus amorphous aggregates.

Adachi M, Noji M, So M, Sasahara K, Kardos J, Naiki H, Goto Y

The Journal of biological chemistry　Vol. 293　No. 38　p. 14775-14785　2018/09　Research paper (scientific journal)

Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization.

Noji M, So M, Yamaguchi K, Hojo H, Onda M, Akazawa-Ogawa Y, Hagihara Y, Goto Y

Biochemistry　Vol. 57　No. 37　p. 5415-5426　2018/08　Research paper (scientific journal)

Structural basis of the correct subunit assembly, aggregation, and intracellular degradation of nylon hydrolase.

Seiji Negoro, Naoki Shibata, Young-Ho Lee, Ikki Takehara, Ryo Kinugasa, Keisuke Nagai, Yusuke Tanaka, Dai-Ichiro Kato, Masahiro Takeo, Yuji Goto, Yoshiki Higuchi

Scientific reports　Vol. 8　No. 1　p. 9725-9725　2018/06/27　Research paper (scientific journal)

Salt-induced formations of partially folded intermediates and amyloid fibrils suggests a common underlying mechanism

Yuji Goto, Masayuki Adachi, Hiroya Muta, Masatomo So

Biophysical Reviews　Vol. 10　No. 2　p. 493-502　2018/04/01

Membrane-induced initial structure of α-synuclein control its amyloidogenesis on model membranes.

Terakawa MS, Lee YH, Kinoshita M, Lin Y, Sugiki T, Fukui N, Ikenoue T, Kawata Y, Goto Y

Biochimica et biophysica acta. Biomembranes　Vol. 1860　No. 3　p. 757-766　2018/03　Research paper (scientific journal)

A new look at an old view of denaturant induced protein unfolding

Damien Hall, Akira Kinjo, Yuji Goto

Analytical Biochemistry　Vol. 542　p. 40-57　2018/02/01　Research paper (scientific journal)

Nanoscale Dynamics of Protein Assembly Networks in Supersaturated Solutions

Y. Matsushita, H. Sekiguchi, C. Jae Wong, M. Nishijima, K. Ikezaki, D. Hamada, Y. Goto, Y. C. Sasaki

Scientific Reports　Vol. 7　No. 1　2017/12/01　Research paper (scientific journal)

Role of An Intramolecular Disulfide Bond in Stability of Lipocalin-Type Prostaglandin D Synthase

Yoshiaki Teraoka, Yoshiaki Teraoka, Shogo Atsuji, Young-Ho Lee, Yuji Goto, Takashi Inui

PROTEIN SCIENCE　Vol. 26　p. 107-107　2017/12

Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation

Ayame Nitani, Hiroya Muta, Masayuki Adachi, Masatomo So, Kenji Sasahara, Kazumasa Sakurai, Eri Chatani, Kazumitsu Naoe, Hirotsugu Ogi, Damien Hall, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 292　No. 52　p. 21219-21230　2017/12　Research paper (scientific journal)

Non-Native α-Helices in the Initial Folding Intermediate Facilitate the Ordered Assembly of the β-Barrel in β-Lactoglobulin.

Sakurai K, Yagi M, Konuma T, Takahashi S, Nishimura C, Goto Y

Biochemistry　Vol. 56　No. 36　p. 4799-4807　2017/09

マイクロ秒 過飽和 状態の ダイナミクス観察

松下 祐福, 関口 博史, 太田 昇, 一柳 光平, 池崎 圭吾, 後藤 祐児, 佐々木 裕次

日本結晶成長学会誌　Vol. 44　2017/08

Non-Native alpha-Helices in the Initial Folding Intermediate Facilitate the Ordered Assembly of the beta-Barrel in beta-Lactoglobulin

Sakurai, K, Yagi, M, Konuma, T, Takahashi, S, Nishimura, C, Goto, Y

Biochemistry　2017/08　Research paper (scientific journal)

Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-beta peptides

Misaki Kinoshita, Erina Kakimoto, Mayu S. Terakawa, Yuxi Lin, Tatsuya Ikenoue, Masatomo So, Toshihiko Sugiki, Ayyalusamy Ramamoorthy, Yuji Goto, Young-Ho Lee

PHYSICAL CHEMISTRY CHEMICAL PHYSICS　Vol. 19　No. 24　p. 16257-16266　2017/06　Research paper (scientific journal)

Drastic acceleration of fibrillation of insulin by transient cavitation bubble

Kichitaro Nakajima, Daisuke Nishioka, Masahiko Hirao, Masatomo So, Yuji Goto, Hirotsugu Ogi

Ultrasonics Sonochemistry　Vol. 36　p. 206-211　2017/05/01　Research paper (scientific journal)

Heparin-induced amyloid fibrillation of (2)-microglobulin explained by solubility and a supersaturation-dependent conformational phase diagram

Masatomo So, Yasuko Hata, Hironobu Naiki, Yuji Goto

PROTEIN SCIENCE　Vol. 26　No. 5　p. 1024-1036　2017/05　Research paper (scientific journal)

Optimized Ultrasonic Irradiation Finds Out Ultrastable A beta(1-40) Oligomers

Kichitaro Nakajima, Masatomo So, Kazuma Takahashi, Yoh-ichi Tagawa, Masahiko Hirao, Yuji Goto, Hirotsugu Ogi

JOURNAL OF PHYSICAL CHEMISTRY B　Vol. 121　No. 12　p. 2603-2613　2017/03　Research paper (scientific journal)

Variation of Free-Energy Landscape of the p53 C-Terminal Domain Induced by Acetylation: Enhanced Conformational Sampling

Shinji Iida, Tadaaki Mashimo, Takashi Kurosawa, Hironobu Hojo, Hiroya Muta, Yuji Goto, Yoshifumi Fukunishi, Haruki Nakamura, Junichi Higo

JOURNAL OF COMPUTATIONAL CHEMISTRY　Vol. 37　No. 31　p. 2687-2700　2016/12　Research paper (scientific journal)

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity.

Kim JY, Kinoshita M, Kume S, Gt H, Sugiki T, Ladbury JE, Kojima C, Ikegami T, Kurisu G, Goto Y, Hase T, Lee YH

The Biochemical journal　Vol. 473　No. 21　p. 3837-3854　2016/11

Recognizing and analyzing variability in amyloid formation kinetics: Simulation and statistical methods

Damien Hall, Ran Zhao, Masatomo So, Masayuki Adachi, German Rivas, John A. Carver, Yuji Goto

ANALYTICAL BIOCHEMISTRY　Vol. 510　p. 56-71　2016/10　Research paper (scientific journal)

A small-angle X-ray scattering study of alpha-synuclein from human red blood cells.

Katsuya Araki, Naoto Yagi, Rie Nakatani, Hiroshi Sekiguchi, Masatomo So, Hisashi Yagi, Noboru Ohta, Yoshitaka Nagai, Yuji Goto, Hideki Mochizuki

Scientific reports　Vol. 6　p. 30473-30473　2016/07/29　Research paper (scientific journal)

Thioflavin T-Silent Denaturation Intermediates Support the Main-Chain-Dominated Architecture of Amyloid Fibrils

Sayaka Noda, Masatomo So, Masayuki Adachi, Jozsef Kardos, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yuji Goto

BIOCHEMISTRY　Vol. 55　No. 28　p. 3937-3948　2016/07　Research paper (scientific journal)

Protein aggregate turbidity: Simulation of turbidity profiles for mixed-aggregation reactions

Damien Hall, Ran Zhao, Ian Dehlsen, Nathaniel Bloomfield, Steven R. Williams, Fumio Arisaka, Yuji Goto, John A. Carver

Analytical Biochemistry　Vol. 498　p. 78-94　2016/04　Research paper (scientific journal)

A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions

Cardine N. Nokwe, Manuel Hora, Martin Zacharias, Hisashi Yagi, Jirka Peschek, Bernd Reif, Yuji Goto, Johannes Buchner

JOURNAL OF MOLECULAR BIOLOGY　Vol. 428　No. 6　p. 1315-1332　2016/03　Research paper (scientific journal)

Amorphous Aggregation of Cytochrome c with Inherently Low Amyloidogenicity Is Characterized by the Metastability of Supersaturation and the Phase Diagram

Yuxi Lin, Jozsef Kardos, Mizue Imai, Tatsuya Ikenoue, Misaki Kinoshita, Toshihiko Sugiki, Koichiro Ishimori, Yuji Goto, Young-Ho Lee

LANGMUIR　Vol. 32　No. 8　p. 2010-2022　2016/03　Research paper (scientific journal)

Amorphous Aggregation of Cytochrome C with Inherently low Amyloidogenicity is Characterized by the Metastability of Supersaturation and the Phase Diagram

Yuxi Lin, Jozsef Kardos, Koichiro Ishimori, Yuji Goto, Young-Ho Lee

BIOPHYSICAL JOURNAL　Vol. 110　No. 3　p. 399A-399A　2016/02

Revisiting supersaturation as a factor determining amyloid fibrillation

Masatomo So, Damien Hall, Yuji Goto

CURRENT OPINION IN STRUCTURAL BIOLOGY　Vol. 36　p. 32-39　2016/02　Research paper (scientific journal)

Nucleus factory on cavitation bubble for amyloid beta fibril

Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi, Yuji Goto

SCIENTIFIC REPORTS　Vol. 6　2016/02　Research paper (scientific journal)

A14 Rapid aggregate reaction of prion protein under the continuous ultrasonication

Yamaguchi Keiichi, Goto Yuji, Kuwata Kazuo

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 25　p. 97-98　2016

A15 The effects of ultrasonication on amyloid fibrils

So Masatomo, Goto Yuji

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 25　p. 99-100　2016

P28 Ultrasonic power-dependent competitive formation of amyloid fibrils and amorphous aggregates

Adachi Masayuki, So Masatomo, Sakurai Kazumasa, Kardos Jozef, Goto Yuji

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 25　p. 87-88　2016

P27 Supersaturation-limited amyloid fibrillation revealed by ultrasonication

Muta Hiroya, Lee Young-Ho, Kardos Jozef, Lin Yuxi, Yagi Hisashi, So Masatomo, Sakurai Kazumasa, Goto Yuji

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 25　p. 85-86　2016

P29 Amyloid fibrillation of hen egg white lysozyme accelerated by ultrasonication

Nitani Ayame, Muta Hiroya, Adachi Masayuki, So Masatomo, Goto Yuji

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 25　p. 89-90　2016

Measurement of amyloid formation by turbidity assay-seeing through the cloud.

Ran Zhao, Masatomo So, Hendrik Maat, Nicholas J Ray, Fumio Arisaka, Yuji Goto, John A Carver, Damien Hall

Biophysical reviews　Vol. 8　No. 4　p. 445-471　2016　Research paper (scientific journal)

Thermal and chemical unfolding pathways of PaSdsA1 sulfatase, a homo-dimer with topologically interlinked chains

Cesar Aguirre, Yuji Goto, Miguel Costas

FEBS LETTERS　Vol. 590　No. 2　p. 202-214　2016/01　Research paper (scientific journal)

Time-resolved X-ray Tracking of Expansion and Compression Dynamics in Supersaturating Ion-Networks.

Y Matsushita, H Sekiguchi, K Ichiyanagi, N Ohta, K Ikezaki, Y Goto, Y C Sasaki

Scientific reports　Vol. 5　p. 17647-17647　2015/12/14　Research paper (scientific journal)

Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients.

Katsuya Araki, Naoto Yagi, Yuka Ikemoto, Hisashi Yagi, Chi-Jing Choong, Hideki Hayakawa, Goichi Beck, Hisae Sumi, Harutoshi Fujimura, Taro Moriwaki, Yoshitaka Nagai, Yuji Goto, Hideki Mochizuki

Scientific reports　Vol. 5　p. 17625-17625　2015/12/01

The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation

Cardine N. Nokwe, Manuel Hora, Martin Zacharias, Hisashi Yagi, Christine John, Bernd Reif, Yuji Goto, Johannes Buchner

JOURNAL OF MOLECULAR BIOLOGY　Vol. 427　No. 22　p. 3572-3586　2015/11　Research paper (scientific journal)

Cold Denaturation of Alpha-Synuclein Amyloid Fibrils

Young-Ho Lee, Tatsuya Ikenoue, Yasushi Kawata, Yuji Goto

PROTEIN SCIENCE　Vol. 24　p. 91-91　2015/10

Delicate Balance of Noncovalent Forces Control the Electron Transfer Complex between Ferredoxin and Sulfite Reductase to Optimize Enzymatic Activity

Juyaen Kim, Misaki Kinoshita, Takahisa Ikegami, Genji Kurisu, Yuji Goto, Toshiharu Hase, Young-Ho Lee

PROTEIN SCIENCE　Vol. 24　p. 64-65　2015/10

Effects of a reduced disulfide bond on aggregation properties of the human IgG1 CH3 domain.

Sakurai K, Nakahata R, Lee YH, Kardos J, Ikegami T, Goto Y

Biochimica et biophysica acta　Vol. 1854　No. 10,Pt.A　p. 1526-1535　2015/10

Supersaturation-Limited and Unlimited Phase Spaces Compete to Produce Maximal Amyloid Fibrillation near the Critical Micelle Concentration of Sodium Dodecyl Sulfate

Masatomo So, Akira Ishii, Yasuko Hata, Hisashi Yagi, Hironobu Naiki, Yuji Goto

LANGMUIR　Vol. 31　No. 36　p. 9973-9982　2015/09　Research paper (scientific journal)

Highly Collapsed Conformation of the Initial Folding Intermediates of β-Lactoglobulin with Non-Native α-Helix

Tsuyoshi Konuma, Kazumasa Sakurai, Masanori Yagi, Yuji Goto, Teturo Fujisawa, Satoshi Takahashi

Journal of Molecular Biology　Vol. 427　No. 19　p. 3158-3165　2015/09　Research paper (scientific journal)

Supersaturation-limited and Unlimited Phase Transitions Compete to Produce the Pathway Complexity in Amyloid Fibrillation.

Adachi M, So M, Sakurai K, Kardos J, Goto Y

The Journal of biological chemistry　Vol. 290　No. 29　p. 18134-18145　2015/07/17

Nucleation-fibrillation dynamics of A beta(1-40) peptides on liquid-solid surface studied by total-internal-reflection fluorescence microscopy coupled with quartz-crystal microbalance biosensor

Hiroki Hamada, Hirotsugu Ogi, Kentaro Noi, Hisashi Yagi, Yuji Goto, Masahiko Hirao

JAPANESE JOURNAL OF APPLIED PHYSICS　Vol. 54　No. 7　2015/07　Research paper (scientific journal)

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

Andras Micsonai, Frank Wien, Linda Kernya, Young-Ho Lee, Yuji Goto, Matthieu Refregiers, Jozsef Kardos

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 112　No. 24　p. E3095-E3103　2015/06　Research paper (scientific journal)

Nucleation–fibrillation dynamics of Aβ

Hamada Hiroki, Ogi Hirotsugu, Noi Kentaro, Yagi Hisashi, Goto Yuji, Hirao Masahiko

Jpn. J. Appl. Phys.　Vol. 54　No. 7　2015/05/12

A multi-pathway perspective on protein aggregation: implications for control of the rate and extent of amyloid formation.

Damien Hall, József Kardos, Herman Edskes, John A Carver, Yuji Goto

FEBS letters　Vol. 589　No. 6　p. 672-9　2015/03/12　Research paper (scientific journal)

Ultrasonication-dependent formation and degradation of alpha-synuclein amyloid fibrils

Hisashi Yagi, Aiko Mizuno, Masatomo So, Miki Hirano, Masayuki Adachi, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Tatsuya Ikenoue, Young-Ho Lee, Yasushi Kawata, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1854　No. 3　p. 209-217　2015/03　Research paper (scientific journal)

Ultrasonication-dependent formation and degradation of α-synuclein amyloid fibrils.

Yagi H, Mizuno A, So M, Hirano M, Adachi M, Akazawa-Ogawa Y, Hagihara Y, Ikenoue T, Lee YH, Kawata Y, Goto Y

Biochimica et biophysica acta　Vol. 1854　No. 3　p. 209-217　2015/03

Investigation of Protein-Protein Interactions of Ferredoxin and Sulfite Reductase Under Different Sodium Chloride Concentrations by NMR Spectroscopy and Isothermal Titration Calorimetry

Ju Yaen Kim, Takahisa Ikegami, Yuji Goto, Toshiharu Hase, Young-Ho Lee

MOLECULAR PHYSIOLOGY AND ECOPHYSIOLOGY OF SULFUR　p. 169-177　2015　Research paper (international conference proceedings)

Small Liposomes Accelerate the Fibrillation of Amyloid beta (1-40)

Mayu S. Terakawa, Hisashi Yagi, Masayuki Adachi, Young-Ho Lee, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 2　p. 815-826　2015/01　Research paper (scientific journal)

Ultrafast propagation of beta-amyloid fibrils in oligomeric cloud

Hirotsugu Ogi, Masahiko Fukukshima, Hiroki Hamada, Kentaro Noi, Masahiko Hirao, Hisashi Yagi, Yuji Goto

SCIENTIFIC REPORTS　Vol. 4　2014/11　Research paper (scientific journal)

Elongation of amyloid fibrils through lateral binding of monomers revealed by total internal reflection fluorescence microscopy

Hisashi Yagi, Yuki Abe, Naoto Takayanagi, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1844　No. 10　p. 1881-1888　2014/10　Research paper (scientific journal)

A Residue-specific Shift in Stability and Amyloidogenicity of Antibody Variable Domains

Cardine N. Nokwe, Martin Zacharias, Hisashi Yagi, Manuel Hora, Bernd Reif, Yuji Goto, Johannes Buchner

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 39　p. 26829-26846　2014/09　Research paper (scientific journal)

High-throughput Analysis of Ultrasonication-forced Amyloid Fibrillation Reveals the Mechanism Underlying the Large Fluctuation in the Lag Time

Ayaka Umemoto, Hisashi Yagi, Masatomo So, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 39　p. 27290-27299　2014/09　Research paper (scientific journal)

Self-assembly of the chaperonin GroEL nanocage induced at submicellar detergent

Jin Chen, Hisashi Yagi, Yuji Furutani, Takashi Nakamura, Asumi Inaguma, Hao Guo, Yan Kong, Yuji Goto

SCIENTIFIC REPORTS　Vol. 4　2014/07　Research paper (scientific journal)

Cold denaturation of α-synuclein amyloid fibrils.

Ikenoue T, Lee YH, Kardos J, Saiki M, Yagi H, Kawata Y, Goto Y

Angewandte Chemie (International ed. in English)　Vol. 53　No. 30　p. 7799-7804　2014/07　Research paper (scientific journal)

Supersaturation-limited Amyloid Fibrillation of Insulin Revealed by Ultrasonication

Hiroya Muta, Young-Ho Lee, Jozsef Kardos, Yuxi Lin, Hisashi Yagi, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 26　p. 18228-18238　2014/06　Research paper (scientific journal)

Heat-induced Irreversible Denaturation of the Camelid Single Domain VHH Antibody Is Governed by Chemical Modifications

Yoko Akazawa-Ogawa, Mizuki Takashima, Young-Ho Lee, Takahisa Ikegami, Yuji Goto, Koichi Uegaki, Yoshihisa Hagihara

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 22　p. 15666-15679　2014/05　Research paper (scientific journal)

Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry

Tatsuya Ikenoue, Young-Ho Lee, Jozsef Kardos, Hisashi Yagi, Takahisa Ikegami, Hironobu Naiki, Yuji Goto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 18　p. 6654-6659　2014/05　Research paper (scientific journal)

Fine-tuned broad binding capability of human lipocalin-type prostaglandin D synthase for various small lipophilic ligands

Satoshi Kume, Young-Ho Lee, Masatoshi Nakatsuji, Yoshiaki Teraoka, Keisuke Yamaguchi, Yuji Goto, Takashi Inui

FEBS LETTERS　Vol. 588　No. 6　p. 962-969　2014/03　Research paper (scientific journal)

Solubility and Supersaturation-Dependent Protein Misfolding Revealed by Ultrasonication

Yuxi Lin, Young-Ho Lee, Yuichi Yoshimura, Hisashi Yagi, Yuji Goto

LANGMUIR　Vol. 30　No. 7　p. 1845-1854　2014/02　Research paper (scientific journal)

Acceleration of the depolymerization of amyloid 13 fibrils by ultrasonication

Hisashi Yagi, Kyohei Hasegawa, Yuichi Yoshimura, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1834　No. 12　p. 2480-2485　2013/12　Research paper (scientific journal)

A common mechanism underlying amyloid fibrillation and protein crystallization revealed by the effects of ultrasonication

Hiroki Kitayama, Yuichi Yoshimura, Masatomo So, Kazumasa Sakurai, Hisashi Yagi, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1834　No. 12　p. 2640-2646　2013/12　Research paper (scientific journal)

Acceleration of the depolymerization of amyloid β fibrils by ultrasonication.

Yagi H, Hasegawa K, Yoshimura Y, Goto Y

Biochimica et biophysica acta　Vol. 1834　No. 12　p. 2480-2485　2013/12

A common mechanism underlying amyloid fibrillation and protein crystallization revealed by the effects of ultrasonication.

Kitayama H, Yoshimura Y, So M, Sakurai K, Yagi H, Goto Y

Biochimica et biophysica acta　Vol. 1834　No. 12　p. 2640-2646　2013/12

Remaining structures at the N- and C-terminal regions of alpha-synuclein accurately elucidated by amide-proton exchange NMR with fitting.

Okazaki H, Ohori Y, Komoto M, Lee YH, Goto Y, Tochio N, Nishimura C

FEBS letters　Vol. 587　No. 22　p. 3709-3714　2013/11

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin roles of shear flow, hydrophobic surfaces, and α-crystallin

P. Patrizia Mangione, Gennaro Esposito, Annalisa Relini, Sara Raimondi, Riccardo Porcari, Sofia Giorgetti, Alessandra Corazza, Federico Fogolari, Amanda Penco, Yuji Goto, Young-Ho Lee, Hisashi Yagi, Ciro Cecconi, Mohsin M. Naqvi, Julian D. Gillmore, Philip N. Hawkins, Fabrizio Chiti, Ranieri Rolandi, Graham W. Taylor, Mark B. Pepys, Monica Stoppini, Vittorio Bellotti

Journal of Biological Chemistry　Vol. 288　No. 43　p. 30917-30930　2013/10/25　Research paper (scientific journal)

Benzalkonium Chloride Accelerates the Formation of the Amyloid Fibrils of Corneal Dystrophy-associated Peptides

Yusuke Kato, Hisashi Yagi, Yuichi Kaji, Tetsuro Oshika, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 288　No. 35　p. 25109-25118　2013/08　Research paper (scientific journal)

Ultrasonication: An Efficient Agitation for Accelerating the Supersaturation-Limited Amyloid Fibrillation of Proteins

Yoshimura Yuichi, So Masatomo, Yagi Hisashi, Goto Yuji

Jpn J Appl Phys　Vol. 52　No. 7　p. 07HA01-07HA01-8　2013/07/25

Mechanisms of ultrasonically induced fibrillation of amyloid β<inf>1-40</inf> peptides

Kentaro Uesugi, Hirotsugu Ogi, Masahiko Fukushima, Masatomo So, Hisashi Yagi, Yuji Goto, Masahiko Hirao

Japanese Journal of Applied Physics　Vol. 52　No. 7 PART 2　2013/07　Research paper (scientific journal)

Acceleration of deposition of A beta(1-40) peptide on ultrasonically formed A beta(1-42) nucleus studied by wireless quartz-crystal-microbalance biosensor

Hirotsugu Ogi, Masahiko Fukushima, Kentaro Uesugi, Hisashi Yagi, Yuji Goto, Masahiko Hirao

BIOSENSORS & BIOELECTRONICS　Vol. 40　No. 1　p. 200-205　2013/02　Research paper (scientific journal)

Effect of liposome membranes on disaggregation of amyloid beta fibrils by dopamine

Huong Thi Vu, Toshinori Shimanouchi, Daisuke Ishikawa, Tadaharu Matsumoto, Hisashi Yagi, Yuji Goto, Hiroshi Umakoshi, Ryoichi Kuboi

BIOCHEMICAL ENGINEERING JOURNAL　Vol. 71　p. 118-126　2013/02　Research paper (scientific journal)

A12 Ultrasonication-dependent breakdown of protein supersaturation and formation of amyloid fibrils

Goto Yuji

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 22　p. 107-108　2013

2P071 Direct observation of burst of amyloid fibril formation by calorimetry(01C. Protein: Property)

Ikenoue Tatsuya, Lee Young-Ho, Kardos Jozef, Goto Yuji

Seibutsu Butsuri　Vol. 53　No. 1　2013

2P066 The effects of the hydrophobic area of vesicles on the fibrillation of Aβ(01C. Protein: Property)

Suzuki Mayu, Yagi Hisashi, Goto Yuji

Seibutsu Butsuri　Vol. 53　No. 1　2013

2P068 The properties of the residual structure of amyloid precursor state of β2-microglobulin(01C. Protein: Property)

Sakurai Kazumasa, Maeno Akihiro, Naiki Hironobu, Goto Yuji, Akasaka Kazuyuki

Seibutsu Butsuri　Vol. 53　No. 1　2013

2P067 Effects of various fatty acids on the amyloid fibrillation of β_2-microglobulin(01C. Protein: Property)

Ishii Akira, So Masatomo, Yagi Hisashi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 53　No. 1　2013

2P070 Solubility and Supersaturation-Dependent Protein Misfolding Revealed by Ultrasonication(01C. Protein: Property)

Lin Yuxi, Lee Young-Ho, Yoshimura Yuichi, Yagi Hisashi, Goto Yuji

Seibutsu Butsuri　Vol. 53　No. 1　2013

2P069 The mechanism of ultrasonication-induced amyloid fibril formation(01C. Protein: Property)

So Masatomo, Yoshimura Yuichi, Yagi Hisashi, Ogi Hirotsugu, Uesugi Kentaro, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 53　No. 1　2013

Application and use of differential scanning calorimetry in studies of thermal fluctuation associated with amyloid fibril formation

Kenji Sasahara, Yuji Goto

Biophysical Reviews　Vol. 5　No. 3　p. 259-269　2013

Principal component analysis of chemical shift perturbation data of a multiple-ligand-binding system for elucidation of respective binding mechanism

Tsuyoshi Konuma, Young-Ho Lee, Yuji Goto, Kazumasa Sakurai

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS　Vol. 81　No. 1　p. 107-118　2013/01　Research paper (scientific journal)

The Molten Globule of beta(2)-Microglobulin Accumulated at pH 4 and Its Role in Protein Folding

Atsushi Mukaiyama, Takashi Nakamura, Koki Makabe, Kosuke Maki, Yuji Goto, Kunihiro Kuwajima

JOURNAL OF MOLECULAR BIOLOGY　Vol. 425　No. 2　p. 273-291　2013/01　Research paper (scientific journal)

Native-State Heterogeneity of beta(2)-Microglobulin as Revealed by Kinetic Folding and Real-Time NMR Experiments

Atsushi Mukaiyama, Takashi Nakamura, Koki Makabe, Kosuke Maki, Yuji Goto, Kunihiro Kuwajima

JOURNAL OF MOLECULAR BIOLOGY　Vol. 425　No. 2　p. 257-272　2013/01　Research paper (scientific journal)

Kinetic intermediates of amyloid fibrillation studied by hydrogen exchange methods with nuclear magnetic resonance

Young-Ho Lee, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1824　No. 12　p. 1307-1323　2012/12

Formation of spherulitic amyloid β aggregate by anionic liposomes

Toshinori Shimanouchi, Naoya Shimauchi, Ryo Ohnishi, Nachi Kitaura, Hisashi Yagi, Yuji Goto, Hiroshi Umakoshi, Ryoichi Kuboi

Biochemical and Biophysical Research Communications　Vol. 426　No. 2　p. 165-171　2012/09/21　Research paper (scientific journal)

Systematic interaction analysis of human lipocalin-type prostaglandin D synthase with small lipophilic ligands

Satoshi Kume, Young-Ho Lee, Yuya Miyamoto, Harumi Fukada, Yuji Goto, Takashi Inui

BIOCHEMICAL JOURNAL　Vol. 446　p. 279-289　2012/09　Research paper (scientific journal)

The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques.

Yanagi K, Sakurai K, Yoshimura Y, Konuma T, Lee YH, Sugase K, Ikegami T, Naiki H, Goto Y

Journal of molecular biology　Vol. 422　No. 3　p. 390-402　2012/09　Research paper (scientific journal)

Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation.

Yoshimura Y, Lin Y, Yagi H, Lee YH, Kitayama H, Sakurai K, So M, Ogi H, Naiki H, Goto Y

Proceedings of the National Academy of Sciences of the United States of America　Vol. 109　No. 36　p. 14446-14451　2012/09　Research paper (scientific journal)

The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques.

Yanagi K, Sakurai K, Yoshimura Y, Konuma T, Lee YH, Sugase K, Ikegami T, Naiki H, Goto Y

J Mol Biol　Vol. 422　No. 3　p. 390-402　2012/09　Research paper (scientific journal)

Long-term observation of fluorescence of free single molecules to explore protein-folding energy landscapes.

Kamagata K, Kawaguchi T, Iwahashi Y, Baba A, Fujimoto K, Komatsuzaki T, Sambongi Y, Goto Y, Takahashi S

Journal of the American Chemical Society　Vol. 134　No. 28　p. 11525-11532　2012/07/18　Research paper (scientific journal)

A back hydrogen exchange procedure via the acid-unfolded state for a large protein.

Suzuki M, Sakurai K, Lee YH, Ikegami T, Yokoyama K, Goto Y

Biochemistry　Vol. 51　No. 28　p. 5564-5570　2012/07

Polymorphism of β2-microglobulin amyloid fibrils manifested by ultrasonication-enhanced fibril formation in trifluoroethanol.

Chatani E, Yagi H, Naiki H, Goto Y

The Journal of biological chemistry　Vol. 287　No. 27　p. 22827-22837　2012/06

Kinetic Intermediate of β_2-microglobulin Fibril Elongation Probed by Tryptophan Fluorescence Spectroscopy and H/D Exchange-NMR

CHATANI Eri, KONUMA Tsuyoshi, GOTO Yuji

Seibutsu Butsuri　Vol. 52　No. 3　p. 148-149　2012/05/25

Fibrillogenic propensity of the GroEL apical domain: A Janus-faced minichaperone

Jin Chen, Hisashi Yagi, Pietro Sormanni, Michele Vendruscolo, Koki Makabe, Takashi Nakamura, Yuji Goto, Kunihiro Kuwajima

FEBS Letters　Vol. 586　No. 8　p. 1120-1127　2012/04/24　Research paper (scientific journal)

Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase

Ayano Fukuhara, Hidemitsu Nakajima, Yuya Miyamoto, Katsuaki Inoue, Satoshi Kume, Young-Ho Lee, Masanori Noda, Susumu Uchiyama, Shigeru Shimamoto, Shigenori Nishimura, Tadayasu Ohkubo, Yuji Goto, Tadayoshi Takeuchi, Takashi Inui

JOURNAL OF CONTROLLED RELEASE　Vol. 159　No. 1　p. 143-150　2012/04　Research paper (scientific journal)

Three-dimensional structure of nylon hydrolase and mechanism of nylon-6 hydrolysis.

Negoro S, Shibata N, Tanaka Y, Yasuhira K, Shibata H, Hashimoto H, Lee YH, Oshima S, Santa R, Oshima S, Mochiji K, Goto Y, Ikegami T, Nagai K, Kato D, Takeo M, Higuchi Y

The Journal of biological chemistry　Vol. 287　No. 7　p. 5079-5090　2012/02　Research paper (scientific journal)

A13 Ultrasonication-dependent breakdown of protein supersaturations

Goto Yuji

Proceedings of the Annual Meeting of the Japan Society of Sonochemistry　Vol. 21　p. 83-84　2012

1E1436 Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation(Proteins: Property I,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)

Yoshimura Yuichi, Lin Yuxi, Yagi Hisashi, Lee Young-Ho, Kitayama Hiroki, Sakurai Kazumasa, So Masatomo, Ogi Hirotsugu, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 52　2012

1PT145 Correlation of the dynamics of β_2-microglobulin fragments with their amyloidogenicity(The 50th Annual Meeting of the Biophysical Society of Japan)

Takeda Mahoshi, Sakurai Kazumasa, Ikegami Takahisa, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 52　2012

A Two-Step Refolding of Acid-Denatured Microbial Transglutaminase Escaping from the Aggregation-Prone Intermediate

Mototaka Suzuki, Kei-ichi Yokoyama, Young-Ho Lee, Yuji Goto

BIOCHEMISTRY　Vol. 50　No. 47　p. 10390-10398　2011/11　Research paper (scientific journal)

Chiral Superstructures of Insulin Amyloid Fibrils

Viktoria Babenko, Takunori Harada, Hisashi Yagi, Yuji Goto, Reiko Kuroda, Wojciech Dzwolak

CHIRALITY　Vol. 23　No. 8　p. 638-646　2011/09　Research paper (scientific journal)

Binding Energetics of Ferredoxin-NADP(+) Reductase with Ferredoxin and Its Relation to Function

Young-Ho Lee, Takahisa Ikegami, Daron M. Standley, Kazumasa Sakurai, Toshiharu Hase, Yuji Goto

CHEMBIOCHEM　Vol. 12　No. 13　p. 2062-2070　2011/09　Research paper (scientific journal)

Ultrasonication-dependent acceleration of amyloid fibril formation.

So M, Yagi H, Sakurai K, Ogi H, Naiki H, Goto Y

Journal of molecular biology　Vol. 412　No. 4　p. 568-577　2011/09

Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a

Isao Suetake, Yuichi Mishima, Hironobu Kimura, Young-Ho Lee, Yuji Goto, Hideyuki Takeshima, Takahisa Ikegami, Shoji Tajima

BIOCHEMICAL JOURNAL　Vol. 437　No. 1　p. 141-148　2011/07　Research paper (scientific journal)

Hexafluoroisopropanol Induces Amyloid Fibrils of Islet Amyloid Polypeptide by Enhancing Both Hydrophobic and Electrostatic Interactions

Kotaro Yanagi, Mizue Ashizaki, Hisashi Yagi, Kazumasa Sakurai, Young-Ho Lee, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 27　p. 23959-23966　2011/07　Research paper (scientific journal)

A circumventing role for the non-native intermediate in the folding of β-lactoglobulin.

Sakurai K, Fujioka S, Konuma T, Yagi M, Goto Y

Biochemistry　Vol. 50　No. 29　p. 6498-6507　2011/07

Seed-Dependent Deposition Behavior of A beta Peptides Studied with Wireless Quartz-Crystal-Microbalance Biosensor

Hirotsugu Ogi, Yuji Fukunishi, Taiji Yanagida, Hisashi Yagi, Yuji Goto, Masahiko Fukushima, Kentaro Uesugi, Masahiko Hirao

ANALYTICAL CHEMISTRY　Vol. 83　No. 12　p. 4982-4988　2011/06　Research paper (scientific journal)

Reversible Heat-Induced Dissociation of beta(2)-Microglobulin Amyloid Fibrils

Jozsef Kardos, Andras Micsonai, Henriett Pal-Gabor, Eva Petrik, Laszlo Graf, Janos Kovacs, Young-Ho Lee, Hironobu Naiki, Yuji Goto

BIOCHEMISTRY　Vol. 50　No. 15　p. 3211-3220　2011/04　Research paper (scientific journal)

Destruction of Amyloid Fibrils of Keratoepithelin Peptides by Laser Irradiation Coupled with Amyloid-specific Thioflavin

Daisaku Ozawa, Yuichi Kaji, Hisashi Yagi, Kazumasa Sakurai, Toru Kawakami, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 286　No. 12　p. 10856-10863　2011/03　Research paper (scientific journal)

Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin.

Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H

The Journal of biological chemistry　Vol. 286　No. 11　p. 9668-9676　2011/03

Time-Resolved Small-Angle X-ray Scattering Study of the Folding Dynamics of Barnase

Tsuyoshi Konuma, Tetsunari Kimura, Shuzo Matsumoto, Yuji Goto, Tetsuro Fujisawa, Alan R.Fersht, Satoshi Takahashi

Journal of Molecular Biology　Vol. 405　No. 5　p. 1284-1294　2011/02　Research paper (scientific journal)

1D1648 Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions(Protein: Property 1,The 49th Annual Meeting of the Biophysical Society of Japan)

Yanagi Kotaro, Ashizaki Mizue, Yagi Hisashi, Sakurai Kazumasa, Lee Young-Ho, Goto Yuji

Seibutsu Butsuri　Vol. 51　2011

3D0948 Application of CS-PCA (Chemical shift-principle component analysis) to the NMR data on a multiple-ligand-binding system(3D Protein: Structure & Function 2,The 49th Annual Meeting of the Biophysical Society of Japan)

Sakurai Kazumasa, Konuma Tsuyoshi, Goto Yuji

Seibutsu Butsuri　Vol. 51　2011

Visualization of polymorphism in apolipoprotein C-II amyloid fibrils

Chai L. Teoh, Hisashi Yagi, Michael D. W. Griffin, Yuji Goto, Geoffrey J. Howlett

JOURNAL OF BIOCHEMISTRY　Vol. 149　No. 1　p. 67-74　2011/01　Research paper (scientific journal)

Kinetic intermediates of β(2)-microglobulin fibril elongation probed by pulse-labeling H/D exchange combined with NMR analysis.

Konuma T, Chatani E, Yagi M, Sakurai K, Ikegami T, Naiki H, Goto Y

Journal of molecular biology　Vol. 405　No. 3　p. 851-862　2011/01　Research paper (scientific journal)

Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy.

Yoshimura Y, Sakurai K, Lee YH, Ikegami T, Chatani E, Naiki H, Goto Y

Protein science : a publication of the Protein Society　Vol. 19　No. 12　p. 2347-2355　2010/12　Research paper (scientific journal)

A Disulfide-Linked Amyloid-beta Peptide Dimer Forms a Protofibril-like Oligomer through a Distinct Pathway from Amyloid Fibril Formation

Takahiro Yamaguchi, Hisashi Yagi, Yuji Goto, Katsumi Matsuzaki, Masaru Hoshino

BIOCHEMISTRY　Vol. 49　No. 33　p. 7100-7107　2010/08　Research paper (scientific journal)

The amyloid fibrils of the constant domain of immunoglobulin light chain.

Yamamoto K, Yagi H, Lee YH, Kardos J, Hagihara Y, Naiki H, Goto Y

FEBS letters　Vol. 584　No. 15　p. 3348-3353　2010/08

Real-Time Observation of Amyloid-β Fibril Growth by Total Internal Reflection Fluorescence Microscopy

Tadato Ban, Yuji Goto

Protein Misfolding Diseases: Current and Emerging Principles and Therapies　p. 699-709　2010/07/02　Part of collection (book)

Stop-and-go kinetics in amyloid fibrillation

Jesper Ferkinghoff-Borg, Jesper Fonslet, Christian Beyschau Andersen, Sandeep Krishna, Simone Pigolotti, Hisashi Yagi, Yuji Goto, Daniel Otzen, Mogens H. Jensen

PHYSICAL REVIEW E　Vol. 82　No. 1　2010/07　Research paper (scientific journal)

Pre-steady-state kinetic analysis of the elongation of amyloid fibrils of beta(2)-microglobulin with tryptophan mutagenesis.

Chatani E, Ohnishi R, Konuma T, Sakurai K, Naiki H, Goto Y

Journal of molecular biology　Vol. 400(5):1057-66.　No. 5　p. 1057-1066　2010/07　Research paper (scientific journal)

Laser-induced propagation and destruction of amyloid β fibrils

Hisashi Yagi, Daisaku Ozawa, Kazumasa Sakurai, Toru Kawakami, Hiroki Kuyama, Osamu Nishimura, Toshinori Shimanouchi, Ryoichi Kuboi, Hironobu Naiki, Yuji Goto

Journal of Biological Chemistry　Vol. 285　No. 25　p. 19660-19667　2010/06/18　Research paper (scientific journal)

Catechol derivatives inhibit the fibril formation of amyloid-β peptides

Vu Thi Huong, Toshinori Shimanouchi, Naoya Shimauchi, Hisashi Yagi, Hiroshi Umakoshi, Yuji Goto, Ryoichi Kuboi

Journal of Bioscience and Bioengineering　Vol. 109　No. 6　p. 629-634　2010/06/01　Research paper (scientific journal)

The beta-Sheet Structure pH Dependence of the Core Fragments of beta(2)-Microglobulin Amyloid Fibrils

Hirotsugu Hiramatsu, Ming Lu, Yuji Goto, Teizo Kitagawa

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 83　No. 5　p. 495-504　2010/05　Research paper (scientific journal)

Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.

Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H

Biochimica et biophysica acta　Vol. 1804　No. 4　p. 986-995　2010/04

Critical role of interfaces and agitation on the nucleation of A beta amyloid fibrils at low concentrations of A beta monomers

Akiyoshi Morinaga, Kazuhiro Hasegawa, Ryo Nomura, Tadakazu Ookoshi, Daisaku Ozawa, Yuji Goto, Masahito Yamada, Hironobu Naiki

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1804　No. 4　p. 986-995　2010/04　Research paper (scientific journal)

Lysophospholipids and non-esterified fatty acids induce the extension of beta 2-microglobulin-related amyloid fibrils at neutral pH

K. Hasegawa, T. Ookoshi, H. Kimura, N. Takahashi, H. Yoshida, R. Miyazaki, Y. Goto, H. Naiki

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS　Vol. 17　p. 91-91　2010/04

Differences in the Molecular Structure of beta(2)-Microglobulin between Two Morphologically Different Amyloid Fibrils

Hirotsugu Hiramatsu, Ming Lu, Koichi Matsuo, Kunihiko Gekko, Yuji Goto, Teizo Kitagawa

BIOCHEMISTRY　Vol. 49　No. 4　p. 742-751　2010/02　Research paper (scientific journal)

1P063 1YA0930 Identification of transient intermediates of the formation of the β2-microglobulin amyloid fibril by heteronuclear NMR techniques.(Protein:Property,Early Research in Biophysics Award Candidate Presentations,Early Research in Biophysics Award,The 48th Annual Meeting of the Biophysical Society of Japan)

SAKURAI Kazumasa, YANAGI Kotaro, YOSHIMURA Yuichi, KONUMA Tsuyoshi, IKEGAMI Takahisa, NAIKI Hironobu, GOTO Yuji

Seibutsu Butsuri　Vol. 50　No. 2　2010

1P041 Interaction Analysis of Human Lipocalin-type Prostaglandin D Synthase for Small Lipophilic Ligands(Protein:Structure & Function,The 48th Annual Meeting of the Biophysical Society of Japan)

Kume Satoshi, Lee Young-Ho, Miyamoto Yuya, Nishimura Shigenori, Fukuda Harumi, Goto Yuji, Inui Takashi

Seibutsu Butsuri　Vol. 50　No. 2　2010

2P051 High Speed Amyloid Fibrilization Induced by Ultrasonication(The 48th Annual Meeting of the Biophysical Society of Japan)

So Masatomo, Yagi Hisashi, Sakurai Kazumasa, Ogi Hirotsugu, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 50　No. 2　2010

1P064 Analysis of the intermediate state of the formation of the β2-microglobulin amyloid fibril using paramagnetic relaxation enhancement(Protein:Property,The 48th Annual Meeting of the Biophysical Society of Japan)

Fujiwara Kensuke, Sakurai Kazumasa, Yagi Hisashi, So Masatomo, Yoshimura Yuichi, Ikegami Takahisa, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 50　No. 2　2010

Characterization of Amyloid beta Fibrils with An Aqueous Two-Phase System: Implications of Fibril Formation

Toshinori Shimanouchi, Naoya Shimauchi, Keiichi Nishiyama, Huong Thi Vu, Hisashi Yagi, Yuji Goto, Hiroshi Umakoshi, Ryoichi Kuboi

SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN　Vol. 17　p. 121-128　2010　Research paper (scientific journal)

Isolation of short peptide fragments from α-synuclein fibril core identifies a residue important for fibril nucleation: A possible implication for diagnostic applications

Hisashi Yagi, Hideki Takeuchi, Shiho Ogawa, Naomi Ito, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yuji Goto, Yasushi Kawata

Biochim. Biophys. Acta/Proteins and Proteomics　Vol. 1804　No. 10　p. 2077-2087　2010　Research paper (scientific journal)

Introduction to the Special Issue

Paul F. Cook, Yuji Goto, Friedrich Lottspeich

Biochimica et Biophysica Acta - Proteins and Proteomics　Vol. 1794　No. 9　p. 1277-1279　2009/09　Research paper (scientific journal)

NMR-based characterization of a refolding intermediate of beta2-microglobulin labeled using a wheat germ cell-free system.

Kameda A, Morita EH, Sakurai K, Naiki H, Goto Y

Protein science : a publication of the Protein Society　Vol. 18(8):1592-601　No. 8　p. 1592-1601　2009/08

Mechanism of Lysophosphatidic Acid-Induced Amyloid Fibril Formation of beta(2)-Microglobulin in Vitro under Physiological Conditions

Henriett Pal-Gabor, Linda Gombos, Andras Micsonai, Erika Kovacs, Eva Petrik, Janos Kovacs, Laszlo Graf, Judit Fidy, Hironobu Naiki, Yuji Goto, Karoly Liliom, Jozsef Kardos

BIOCHEMISTRY　Vol. 48　No. 24　p. 5689-5699　2009/06　Research paper (scientific journal)

Structural dynamics and folding of beta-lactoglobulin probed by heteronuclear NMR

Kazumasa Sakurai, Tsuyoshi Konuma, Masanori Yagi, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　Vol. 1790　No. 6　p. 527-537　2009/06

Structural dynamics and folding of beta-lactoglobulin probed by heteronuclear NMR.

Sakurai K, Konuma T, Yagi M, Goto Y

Biochimica et biophysica acta　Vol. 1790(6):527-37　No. 6　p. 527-537　2009/06

Thermal response with exothermic effects of beta2-microglobulin amyloid fibrils and fibrillation.

Sasahara K, Yagi H, Naiki H, Goto Y

Journal of molecular biology　Vol. 389　No. 3　p. 584-594　2009/06

Branching in Amyloid Fibril Growth

Christian Beyschau Andersen, Hisashi Yagi, Mauro Manno, Vincenzo Martorana, Tadato Ban, Gunna Christiansen, Daniel Erik Otzen, Yuji Goto, Christian Rischel

BIOPHYSICAL JOURNAL　Vol. 96　No. 4　p. 1529-1536　2009/02　Research paper (scientific journal)

1YP1-02 Long-time observation of a single molecule trapped in a capillary cell : application for protein folding(1YP1 Early Research in Biophysics Award Candidate Presentations,The 47th Annual Meeting of the Biophysical Society of Japan)

Kamagata Kiyoto, Goto Yuji, Takahashi Satoshi

Seibutsu Butsuri　Vol. 49　2009

1TP3-01 A channeling role of the non-native intermediate in the folding of β-lactoglobulin(The 47th Annual Meeting of the Biophysical Society of Japan)

Fujioka Shunsuke, Sakurai Kazumasa, Konuma Tsuyoshi, Yagi Masanori, Goto Yuji

Seibutsu Butsuri　Vol. 49　2009

2P-052 Site directed spin labeling - electron spin resonance analysis of the structure of amyloid fibrils(Protein:Property,The 47th Annual Meeting of the Biophysical Society of Japan)

So Masatomo, Yagi Hisashi, Sakurai kazumasa, Naiki Hironobu, Arata Toshiaki, Goto Yuji

Seibutsu Butsuri　Vol. 49　p. S114-S115　2009

2P-048 Analysis of the mechanism of the amyloid fiber extension using H/D exchange(Protein:Property,The 47th Annual Meeting of the Biophysical Society of Japan)

Yanagi Kotaro, Sakurai Kazumasa, Lee Young-Ho, Ikegami Takahisa, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 49　2009

2P-050 Single molecule observation of the folding of bovine β-lactoglobulin(Protein:Property,The 47th Annual Meeting of the Biophysical Society of Japan)

Kadota Takayuki, Kamagata Kiyoto, Oikawa Hiroyuki, Sakurai Kazumasa, Goto Yuji, Takahashi Satoshi

Seibutsu Butsuri　Vol. 49　2009

2P-038 Direct Observation of β_2-microglubulin amyloid fibrils using solution NMR(Protein:Property,The 47th Annual Meeting of the Biophysical Society of Japan)

Yoshimura Yuichi, Sakurai Kazumasa, Chatani Eri, Lee Young-Ho, Ikegami Takahisa, Kameda Atsushi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 49　2009

Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils

Eri Chatani, Young-Ho Lee, Hisashi Yagi, Yuichi Yoshimura, Hironobu Naiki, Yuji Goto

Proc. Natl. Acad. Sci. USA　Vol. 106　No. 27　p. 11119-11124　2009

A Comprehensive Model for Packing and Hydration for Amyloid Fibrils of beta(2)-Microglobulin

Young-Ho Lee, Eri Chatani, Kenji Sasahara, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 4　p. 2169-2175　2009/01　Research paper (scientific journal)

Destruction of Amyloid Fibrils of a beta(2)-Microglobulin Fragment by Laser Beam Irradiation

Daisaku Ozawa, Hisashi Yagi, Tadato Ban, Atsushi Kameda, Toru Kawakami, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 2　p. 1009-1017　2009/01　Research paper (scientific journal)

Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH

Kazuhiro Hasegawa, Shinobu Tsutsumi-Yasuhara, Tadakazu Ookoshi, Yumiko Ohhashi, Hideki Kimura, Naoki Takahashi, Haruyoshi Yoshida, Ryoichi Miyazaki, Yuji Goto, Hironobu Naiki

BIOCHEMICAL JOURNAL　Vol. 416　p. 307-315　2008/12　Research paper (scientific journal)

Lysophospholipids induce the nucleation and extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH

Tadakazu Ookoshi, Kazuhiro Hasegawa, Yumiko Ohhashi, Hideki Kimura, Naoki Takahashi, Haruyoshi Yoshida, Ryoichi Miyazaki, Yuji Goto, Hironobu Naiki

NEPHROLOGY DIALYSIS TRANSPLANTATION　Vol. 23　No. 10　p. 3247-3255　2008/10　Research paper (scientific journal)

Kinetic Coupling of Folding and Prolyl Isomerization of beta(2)-Microglobulin Studied by Mutational Analysis

Michiko Sakata, Eri Chatani, Atsushi Kameda, Kazumasa Sakurai, Hironobu Naiki, Yuji Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 382　No. 5　p. 1242-1255　2008/10　Research paper (scientific journal)

Structure, Formation and Propagation of Amyloid Fibrils

Yuji Goto, Hisashi Yagi, Keiichi Yamaguchi, Eri Chatani, Tadato Ban

CURRENT PHARMACEUTICAL DESIGN　Vol. 14　No. 30　p. 3205-3218　2008/10

Differential rate constants of racemization of aspartyl and asparaginyl residues in human alpha A-crystallin mutants

Tooru Nakamura, Miyo Sakai, Yutaka Sadakane, Tatsuya Haga, Yuji Goto, Tadatoshi Kinouchi, Takeshi Saito, Noriko Fujii

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1784　No. 9　p. 1192-1199　2008/09　Research paper (scientific journal)

Dehydration of main-chain amides in the final folding step of single-chain monellin revealed by time-resolved infrared spectroscopy

Tetsunari Kimura, Akio Maeda, Shingo Nishiguchi, Koichiro Ishimori, Isao Morishima, Takashi Konno, Yuji Goto, Satoshi Takahashi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 105　No. 36　p. 13391-13396　2008/09　Research paper (scientific journal)

Disulfide-linked bovine beta-lactoglobulin dimers fold slowly, navigating a glassy folding landscape

Masanori Yagi, Atsushi Kameda, Kazumasa Sakurai, Chiaki Nishimura, Yuji Goto

BIOCHEMISTRY　Vol. 47　No. 22　p. 5996-6006　2008/06　Research paper (scientific journal)

Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r

József Kardos, Veronika Harmat, Anna Palló, Orsolya Barabás, Katalin Szilágyi, László Gráf, Gábor Náray-Szabó, Yuji Goto, Péter Závodszky, Péter Gál

Molecular Immunology　Vol. 45　No. 6　p. 1752-1760　2008/03　Research paper (scientific journal)

Amyloid nucleation triggered by agitation of beta(2)-microglobulin under acidic and neutral pH conditions

Kenji Sasahara, Hisashi Yagi, Miyo Sakai, Hironobu Naiki, Yuji Goto

BIOCHEMISTRY　Vol. 47　No. 8　p. 2650-2660　2008/02　Research paper (scientific journal)

Thiol compounds inhibit the formation of amyloid fibrils by beta(2)-microglobulin at neutral pH

Kaori Yamamoto, Hisashi Yagi, Daisaku Ozawa, Kenji Sasahara, Hironobu Naiki, Yuji Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 376　No. 1　p. 258-268　2008/02　Research paper (scientific journal)

Alcohol- and Salt-induced Partially Folded Intermediates

Daizo Hamada, Yuji Goto

Protein Folding Handbook　Vol. 2　p. 884-915　2008/01/31　Part of collection (book)

3P-008 The ability of fibril formation of the constant domain of immunoglobulin light chain in comparison with β2-microglobulin(The 46th Annual Meeting of the Biophysical Society of Japan)

Yamamoto Kaori, Yagi Hisashi, Hagihara Yoshihisa, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

3P-010 Analysis of the amyloid fiber extension mechanism using H/D exchange(The 46th Annual Meeting of the Biophysical Society of Japan)

Yanagi Kotaro, Sakurai Kazumasa, Chatani Eri, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

3P-013 Analysis of native-state prolyl isomerization of β2-microglobulin(The 46th Annual Meeting of the Biophysical Society of Japan)

Mukaiyama Atsushi, Nakamura Takashi, Maki Kosuke, Goto Yuji, Kuwajima Kunihiro

Seibutsu Butsuri　Vol. 48　2008

3P-007 A study of contributions of the α-helix intermediate of β-Lactoglobulin to its folding process(The 46th Annual Meeting of the Biophysical Society of Japan)

Fujioka Shunsuke, Konuma Tsuyoshi, Yagi Masanori, Sakurai Kazumasa, Goto Yuji

Seibutsu Butsuri　Vol. 48　p. S128-S129　2008

3P-005 The effect of the intermolecular disulfide bond in IgG C_H3 domain to its stability(The 46th Annual Meeting of the Biophysical Society of Japan)

Sakurai Kazumasa, Nakahata Ryosuke, Matsumura Masazumi, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

2P-083 Monitoring the fibrillation intermediate of β2-microglobulin by Trp fluorescence and H/D exchange-NMR(The 46th Annual Meeting of the Biophysical Society of Japan)

Chatani Eri, Onishi Reina, Konuma Tsuyoshi, Sakurai Kazumasa, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

2P-008 Structural Analysis of Amyloid Fibrils of β2-Microglobulin by Solid-State NMR(The 46th Annual Meeting of the Biophysical Society of Japan)

Saeka Miwako, Todokoro Yasuto, Egawa Ayako, Kameda Atsushi, Chatani Eri, Yagi Hisashi, Akutsu Hideo, Naiki Hironobu, Fujiwara Toshimichi, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

1P-087 Structural analysis of the amyloid fibril formed by the fragment of β2-microglobulin(The 46th Annual Meeting of the Biophysical Society of Japan)

Yoshimura Yuichi, Sakurai Kazumasa, Chatana Eri, Kameda Atsushi, Sakai Miyo, Yamaguchi Kei-ichi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 48　2008

A cytotoxic conformer of the polyglutamine protein: Exposed beta-sheet hypothesis

Yoshitaka Nagai, Takashi Inui, Akiko Popiel, Nobuhiro Fujikake, Yuji Goto, Hironobu Naiki, Tatsushi Toda

NEUROSCIENCE RESEARCH　Vol. 61　p. S44-S44　2008

β_2-ミクログロブリンアミロイド線維形成・沈着の分子機構 : 第50回日本透析医学会シンポジウムより

山本 卓, 長谷川 一浩, 山口 格, 風間 順一郎, 丸山 弘樹, 成田 一衛, 後藤 祐児, 内木 宏延, 下条 文武

日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy　Vol. 40　No. 12　p. 1028-1030　2007/12/28

Visualization and classification of amyloid β supramolecular assemblies

Hisashi Yagi, Tadato Ban, Kenichi Morigaki, Hironobu Naiki, Yuji Goto

Biochemistry　Vol. 46　No. 51　p. 15009-15017　2007/12/25　Research paper (scientific journal)

Seed-dependent accelerated fibrillation of alpha-synuclein induced by periodic ultrasonication treatment

Hyun Jin Kim, Eri Chatani, Yuji Goto, Seung R. Paik

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY　Vol. 17　No. 12　p. 2027-2032　2007/12　Research paper (scientific journal)

蛋白質の折り畳み運動を観測するための一分子測定手法の開発(Development of a technique for the investigation of folding dynamics of single proteins for extended time periods)

木下 雅仁, 鎌形 清人, 前田 晃央, 後藤 祐児, 小松崎 民樹, 高橋 聡

生物物理　Vol. 47　No. Suppl.1　p. S139-S139　2007/11

[Rise of amyloid structural biology].

Yagi H, Sakurai K, Goto Y

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 52　No. 12　p. 1445-1453　2007/10

Solvation and desolvation dynamics in apomyoglobin folding monitored by time-resolved infrared spectroscopy

Shingo Nishiguchi, Yuji Goto, Satoshi Takahashi

JOURNAL OF MOLECULAR BIOLOGY　Vol. 373　No. 2　p. 491-502　2007/10　Research paper (scientific journal)

High-resolution crystal structure of beta2-microglobulin formed at pH 7.0.

Iwata K, Matsuura T, Sakurai K, Nakagawa A, Goto Y

Journal of biochemistry　Vol. 142　No. 3　p. 413-419　2007/09　Research paper (scientific journal)

Heat-induced conversion of beta(2)-Microglobulin and hen egg-white lysozyme into amyloid fibrils

Kenji Sasahara, Hisashi Yagi, Hironobu Naiki, Yuji Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 372　No. 4　p. 981-991　2007/09　Research paper (scientific journal)

Dimethylsulfoxide-quenched hydrogen/deuterium exchange method to study amyloid fibril structure

Masaru Hoshino, Hidenori Katou, Kei-Ichi Yamaguchi, Yuji Goto

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1768　No. 8　p. 1886-1899　2007/08

Conformational indeterminism in protein misfolding: Chiral amplification on amyloidogenic pathway of insulin

Wojciech Dzwolak, Anna Loksztejn, Agnieszka Galinska-Rakoczy, Rumi Adachi, Yuji Goto, Leszek Rupnicki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 129　No. 24　p. 7517-7522　2007/06　Research paper (scientific journal)

Development of a technique for the investigation of folding dynamics of single proteins for extended time periods

Masahito Kinoshita, Kiyoto Kamagata, Akio Maeda, Yuji Goto, Tamiki Komatsuzaki, Satoshi Takahashi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 25　p. 10453-10458　2007/06　Research paper (scientific journal)

A toxic monomeric conformer of the polyglutamine protein.

Yoshitaka Nagai, Takashi Inui, H Akiko Popiel, Nobuhiro Fujikake, Kazuhiro Hasegawa, Yoshihiro Urade, Yuji Goto, Hironobu Naiki, Tatsushi Toda

Nature structural & molecular biology　Vol. 14　No. 4　p. 332-40　2007/04　Research paper (scientific journal)

Promiscuous binding of ligands by beta-lactoglobulin involves hydrophobic interactions and plasticity.

Konuma T, Sakurai K, Goto Y

Journal of molecular biology　Vol. 368　No. 1　p. 209-218　2007/04　Research paper (scientific journal)

A rapid flow mixer with 11-mu s mixing time microfabricated by a pulsed-laser ablation technique: Observation of a barrier-limited collapse in cytochrome c folding

Shuzo Matsumoto, Akira Yane, Satoru Nakashima, Masaki Hashida, Masayuki Fujita, Yuji Goto, Satoshi Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 129　No. 13　p. 3840-+　2007/04　Research paper (scientific journal)

Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid

Takahisa Kanekiyo, Tadato Ban, Kosuke Aritake, Zhi-Li Huang, Wei-Min Qu, Issay Okazaki, Ikuko Mohri, Shigeo Murayama, Keiichi Ozono, Masako Taniike, Yuji Goto, Yoshihiro Urade

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 15　p. 6412-6417　2007/04　Research paper (scientific journal)

Heat-triggered conversion of protofibrils into mature amyloid fibrils of beta(2)-microglobulin

Kenji Sasahara, Hisashi Yagi, Hironobu Naiki, Yuji Goto

BIOCHEMISTRY　Vol. 46　No. 11　p. 3286-3293　2007/03　Research paper (scientific journal)

Flow-induced alignment of amyloid protofilaments revealed by linear dichroism

Rumi Adachi, Kei-ichi Yamaguchi, Hisashi Yagi, Kazumasa Sakurai, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 12　p. 8978-8983　2007/03　Research paper (scientific journal)

Cores and pH-dependent dynamics of ferredoxin-NADP(+) reductase revealed by hydrogen/deuterium exchange

Young-Ho Lee, Kosuke Tamura, Masahiro Maeda, Masaru Hoshino, Kazumasa Sakurai, Satoshi Takahashi, Takahisa Ikegami, Toshiharu Hase, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 8　p. 5959-5967　2007/02　Research paper (scientific journal)

2P100 Observation of the initial collapse in apomyoglobin folding by ultra-rapid mixing(Proteins-stability, folding, and other physicochemical properties,Poster Presentations)

Tatsumi Tetsuma, Kinoshita Masahito, Goto Yuji, Takahashi Satoshi

Seibutsu Butsuri　Vol. 47　2007

2P104 Development of a technique for the investigation of folding dynamics of single proteins for extended time periods(Proteins-stability, folding, and other physicochemical properties,Poster Presentations)

Kinoshita Masahito, Kamagata Kiyoto, Maeda Akio, Goto Yuji, Komatsuzaki Tamiki, Takahashi Satoshi

Seibutsu Butsuri　Vol. 47　2007

2P092 Equilibrium and kinetics of β_2-Microglobulin from the acid-unfolded state(Proteins-stability, folding, and other physicochemical properties,Oral Presentations)

Mukaiyama Atsushi, Maki Kosuke, Goto Yuji, Kuwajima Kunihiro

Seibutsu Butsuri　Vol. 47　2007

2P094 Direct observation of single-molecule trajectories of protein folding under non-equilibrium condition(Proteins-stability, folding, and other physicochemical properties,Oral Presentations)

Kamagata Kiyoto, Kinoshita Masahito, Goto Yuji, Takahashi Satoshi

Seibutsu Butsuri　Vol. 47　2007

3P048 Packing density of amiloid-like and amyloid fibrils(Proteins-stability, folding, and other physicochemical properties,Poster Presentations)

Lee Young-Ho, Chatani Eri, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 47　2007

3P052 The effects of reductant on the amyloid fibril formation of β2-microglobulin(Proteins-stability, folding, and other physicochemical properties,Poster Presentations)

Yamamoto Kaori, Ozawa Daisaku, Yagi Hisashi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 47　2007

3P055 Uniforming the Molecular Weigh of Amyloid Fibrils by Ultrasonication(Proteins-stability, folding, and other physicochemical properties,Oral Presentations)

Chatani Eri, Adachi Rumi, Sakai Miyo, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 47　2007

2P078 Time-resolved small angle x-ray scattering study on the burst phase intermediate in the folding of bamase(Proteins-stability, folding, and other physicochemical properties,Poster Presentations)

Konuma Tsuyoshi, Kimura Tetsunari, Matsumoto Shuzo, Goto Yuji, Fujisawa Tetsuro, Takahashi Satoshi

Seibutsu Butsuri　Vol. 47　2007

1P058 Principal component analysis of the pH-dependent conformational transitions of bovine β-lactoglobulin monitored by heteronuclear NMR(Proteins-functions, methodology, and protein enigineering,Oral Presentations)

Sakurai Kazumasa, Goto Yuji

Seibutsu Butsuri　Vol. 47　2007

Principal component analysis of the pH-dependent conformational transitions of bovine beta-lactoglobulin monitored by heteronuclear NMR.

Proc. Natl. Acad. Sci. USA　Vol. 104 (39), 15346-15351　2007

Age-related changes of alpha-crystallin aggregate in human lens

N. Fujii, Y. Shimmyo, M. Sakai, Y. Sadakane, T. Nakamura, Y. Morimoto, T. Kinouchi, Y. Goto, K. Lampi

AMINO ACIDS　Vol. 32　No. 1　p. 87-94　2007/01　Research paper (scientific journal)

Dynamics and mechanism of the ligand binding of bovine beta-lactoglobulin studied using heteronuclear NMR spectroscopy.

J. Mol. Biol.　Vol. 368 (1), 209-218　2007

High-resolution crystal structure of beta2-microglobulin formed under physiological conditions.

J. Biochem.　Vol. 142 (3), 413-419　2007

3D structure of amyloid protofilaments of β2-microglobulin fragment probed by solid-state NMR

Kentaro Iwata, Toshimichi Fujiwara, Yoh Matsuki, Hideo Akutsu, Satoshi Takahashi, Hironobu Naiki, Yuji Goto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 103　No. 48　p. 18119-18124　2006/11/28　Research paper (scientific journal)

Real-time and single fibril observation of the formation of amyloid beta spherulitic structures

Tadato Ban, Kenichi Morigaki, Hisashi Yagi, Takashi Kawasaki, Atsuko Kobayashi, Shunsuke Yuba, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 44　p. 33677-33683　2006/11　Research paper (scientific journal)

Flexible docking of an amyloid-forming peptide from beta(2)-microglobulin

Daron M. Standley, Yasushige Yonezawa, Yuji Goto, Haruki Nakamura

FEBS LETTERS　Vol. 580　No. 26　p. 6199-6205　2006/11　Research paper (scientific journal)

Conformation of amyloid fibrils of beta(2)-microglobulin probed by tryptophan mutagenesis

Miho Kihara, Eri Chatani, Kentaro Iwata, Kaori Yamamoto, Takanori Matsuura, Atsushi Nakagawa, Hironobu Naiki, Yuji Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 41　p. 31061-31069　2006/10　Research paper (scientific journal)

Mechanism by which the amyloid-like fibrils of a beta(2)-microglobulin fragment are induced by fluorine-substituted alcohols

Kei-ichi Yamaguchi, Hironobu Naiki, Yuji Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 363　No. 1　p. 279-288　2006/10　Research paper (scientific journal)

Direct observation of amyloid fibril growth, propagation, and adaptation

Tadato Ban, Keiichi Yamaguchi, Yuji Goto

ACCOUNTS OF CHEMICAL RESEARCH　Vol. 39　No. 9　p. 663-670　2006/09

Structure of interacting segments in the growing amyloid fibril of beta(2)-microglobulin probed with IR Spectroscopy

Ming Lu, Hirotsugu Hiramatsu, Yuji Goto, Teizo Kitagawa

JOURNAL OF MOLECULAR BIOLOGY　Vol. 362　No. 2　p. 355-364　2006/09　Research paper (scientific journal)

Exothermic effects observed upon heating of beta(2)-microglobulin monomers in the presence of amyloid seeds

Kenji Sasahara, Hironobu Naiki, Yuji Goto

BIOCHEMISTRY　Vol. 45　No. 29　p. 8760-8769　2006/07　Research paper (scientific journal)

Seeding-dependent propagation and maturation of beta(2)-microglobulin amyloid fibrils under high pressure

Eri Chatani, Hironobu Naiki, Yuji Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 359　No. 4　p. 1086-1096　2006/06　Research paper (scientific journal)

Dynamics and mechanism of the Tanford transition of bovine beta-lactoglobulin studied using Heteronuclear NMR Spectroscopy

K Sakurai, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 356　No. 2　p. 483-496　2006/02　Research paper (scientific journal)

1P112 Multiple time scales in the folding dynamics of single chain monellin revealed by single molecule measurements(3. Protein folding and misfolding (1),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Maeda Akio, Kinoshita Masahito, Kamagata Kiyoto, Konno Takashi, Goto Yuji, Takahashi Satoshi

Seibutsu Butsuri　Vol. 46　No. 2　2006

1P108 Development of sheath-flow system to observe protein folding events at a single-molecule level(3. Protein folding and misfolding (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Kamagata Kiyoto, Kinoshita Masahito, Goto Yuji, Takahashi Satoshi

Seibutsu Butsuri　Vol. 46　No. 2　2006

2P277 Promiscuous ligand binding of β-lactoglobulin allowed by hydrophobic interactions and structural variability(40. Membrane structure,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Konuma Tsuyoshi, Sakurai Kazumasa, Goto Yuji

Seibutsu Butsuri　Vol. 46　No. 2　2006

2P125 Relationship between pH-dependent conformational and stability changes of bovine β-lactoglobulin studied using NMR spectroscopy(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Sakurai Kazumasa, Goto Yuji

Seibutsu Butsuri　Vol. 46　No. 2　2006

2P109 Folding and Unfolding Kinetics of β2-Microglobulin as Probed by Tryptophan Fluorescence(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Sakata Michiko, Chatani Eri, Kameda Atsushi, Sakurai Kazumasa, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 46　No. 2　2006

2P119 Reduction of disulfide bridge inhibits the amyloid fibril formation of β2-microglobulin(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Yamamoto Kaori, Yagi Hisashi, Hasegawa Kazuhiro, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 46　No. 2　2006

2P112 Heat Capacity Change Associated with Structural Conversion into Amyloid Fibril(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Sasahara Kenji, Yagi Hisashi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 46　No. 2　2006

2P105 Structural polymorphism of β_2-microglobulin amyloid fibrils induced by the addition of trifluoroethanol(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Chatani Eri, Yagi Hisashi, Naiki Hironobu, Goto Yuji

Seibutsu Butsuri　Vol. 46　No. 2　2006

alpha B-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta 2-microglobulin

B Raman, T Ban, M Sakai, SY Pasta, T Ramakrishna, H Naiki, Y Goto, CM Rao

BIOCHEMICAL JOURNAL　Vol. 392　p. 573-581　2005/12　Research paper (scientific journal)

Dialysis-related amyloidosis: From molecular mechanism to therapies

Yuji Goto, Vittorio Bellotti, Rino Esposito

Biochimica et Biophysica Acta - Proteins and Proteomics　Vol. 1753　No. 1　p. 1-3　2005/11/10　Research paper (international conference proceedings)

Structural stability of amyloid fibrils of β2-microglobulin in comparison with its native fold

Eri Chatani, Yuji Goto

Biochimica et Biophysica Acta - Proteins and Proteomics　Vol. 1753　No. 1　p. 64-75　2005/11/10　Research paper (international conference proceedings)

Kinetic analysis of the polymerization and depolymerization of beta(2)-microglobulin-related amyloid fibrils in vitro.

Yamamoto S, Hasegawa K, Yamaguchi I, Goto Y, Gejyo F, Naiki H

Biochimica et biophysica acta　Vol. 1753　No. 1　p. 34-43　2005/11

Structural studies reveal that the diverse morphology of beta(2)-microglobulin aggregates is a reflection of different molecular architectures

J Kardos, D Okuno, T Kawai, Y Hagihara, N Yumoto, T Kitagawa, P Zavodszky, H Naiki, Y Goto

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1753　No. 1　p. 108-120　2005/11　Research paper (scientific journal)

Kinetic analysis of the polymerization and depolymerization of beta2-microglobulin-related amyloid fibrils in vitro

S Yamamoto, K Hasegawa, Yamaguchi, I, Y Goto, F Gejyo, H Naiki

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS　Vol. 1753　No. 1　p. 34-43　2005/11　Research paper (scientific journal)

Seeding-dependent propagation and maturation of amyloid fibril conformation

Kei-Ichi Yamaguchi, Satoshi Takahashi, Tomoji Kawai, Hironobu Naiki, Yuji Goto

Journal of Molecular Biology　Vol. 352　No. 4　p. 952-960　2005/09/30　Research paper (scientific journal)

Ultrasonication-induced amyloid fibril formation of beta(2)-microglobulin

Y Ohhashi, M Kihara, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 38　p. 32843-32848　2005/09　Research paper (scientific journal)

Main-chain dominated amyloid structures demonstrated by the effect of high pressure

E Chatani, M Kato, T Kawai, H Naiki, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 352　No. 4　p. 941-951　2005/09　Research paper (scientific journal)

Kinetically controlled thermal response of beta(2)-microglobulin amyloid fibrils

K Sasahara, H Naiki, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 352　No. 3　p. 700-711　2005/09　Research paper (scientific journal)

Identification of the n- and c-terminal substrate binding segments of Ferredoxin-NADP plus reductase by NMR

M Maeda, YH Lee, T Ikegami, K Tamura, M Hoshino, T Yamazaki, M Nakayama, T Hase, Y Goto

BIOCHEMISTRY　Vol. 44　No. 31　p. 10644-10653　2005/08　Research paper (scientific journal)

Direct calorimetric measurement of the thermodynamic parameters of amyloid formation

J Kardos, K Yamamoto, K Hasegawa, H Naiki, L Graf, Y Goto

FEBS JOURNAL　Vol. 272　p. 379-379　2005/07

Structural model of the amyloid fibril formed by beta(2)-microglobulin #21-31 fragment based on vibrational spectroscopy

H Hiramatsu, Y Goto, H Naiki, T Kitagawa

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 127　No. 22　p. 7988-7989　2005/06　Research paper (scientific journal)

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid beta peptide

B Raman, T Ban, K Yamaguchi, M Sakai, T Kawai, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 16　p. 16157-16162　2005/04　Research paper (scientific journal)

Nuclear magnetic resonance characterization of the refolding intermediate of beta(2)-microglobulin trapped by non-native prolyl peptide bond

A Kameda, M Hoshino, T Higurashi, S Takahashi, H Naiki, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 348　No. 2　p. 383-397　2005/04　Research paper (scientific journal)

Molecular interactions in the formation and deposition of beta(2)-microglobuhn-related amyloid fibrils

H Naiki, S Yamamoto, K Hasegawa, Yamaguchi, I, Y Goto, F Gejyo

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS　Vol. 12　No. 1　p. 15-25　2005/03

Seeding-dependent maturation of ss(2)-microglobulin amyloid fibrils at neutral pH

M Kihara, E Chatani, M Sakai, K Hasegawa, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 12　p. 12012-12018　2005/03　Research paper (scientific journal)

Association of thin filaments into thick filaments revealing the structural hierarchy of amyloid fibrils

Takashi Kanno, Keiichi Yamaguchi, Hironobu Naiki, Yuji Goto, Tomoji Kawai

Journal of Structural Biology　Vol. 149　No. 2　p. 213-218　2005/02　Research paper (scientific journal)

Electron transfer reaction in a single protein molecule observed by total internal reflection fluorescence microscopy

Y Furukawa, T Ban, D Hamada, K Ishimori, Y Goto, Morishima, I

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 127　No. 7　p. 2098-2103　2005/02　Research paper (scientific journal)

Critical balance of electrostatic and hydrophobic interactions is required for beta(2)-microglobulin amyloid fibril growth and stability

B Raman, E Chatani, M Kihara, T Ban, M Sakai, K Hasegawa, H Naiki, CM Rao, Y Goto

BIOCHEMISTRY　Vol. 44　No. 4　p. 1288-1299　2005/02　Research paper (scientific journal)

1P012 pH dependence of amyloid fibril structures of b2-microglobulin fragment peptides investigated by IR spectroscopy

Lu M., Hiramatsu H., Goto Y., Kitagawa T.

Seibutsu Butsuri　Vol. 45　2005

2P074 The Structual Model for the Amyloid Fibril Formed by β_2-microglobulin Fragment Based on Solid-state NMR

Iwata K., Fujiwara T., Matsuki Y., Akutsu H., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

2P076 Effects of surface interaction on the Aβ(1-40) amyloid fibril formation and growth

Ban T., Morigaki K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

2P089 Time-resolved fluorescence and resonance raman measurements of the initial collapse in cytochrome c folding

Matsumoto S., Yane A., Goto Y., Hashida M., Fujita M., Nakashima S., Takahashi S.

Seibutsu Butsuri　Vol. 45　2005

2P085 Development of the fluorescence detection device to observe single molecule dynamics of protein folding for extended periods

Maeda A., Kinoshita M., Konno T., Goto Y., Takahashi S.

Seibutsu Butsuri　Vol. 45　2005

2P075 Ultrasonication-induced amyloid fibril formation of beta_2-microglobulin

Ohhashi Y., Kihara M., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

3P046 Structural analysis of amyloid fibrils ofβ2-microglobulin using tryptophan fluorescence probe

Kihara M., Yamamoto K., Iwata K., Chatani E., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

3P067 Study of dynamics and mechanism of Tanford transition of bovine β-lactoglobulin

Sakurai K., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

3P045 Direct observation ofβ_2-microglobulin amyloid fibril formation at neutral pH

Ozawa D., Ban T., Kameda A., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

1P087 Iso-1-Cytochrome c Folding Studied by a New Method of Single Molecule Detection

Kinoshita M., Goto Y., Takahashi S.

Seibutsu Butsuri　Vol. 45　2005

1P097 Transition from non-amyloidogenic aggregates to amyloid fibrils

Sasahara K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

1P095 Analyses of the folding reaction of the bovine β-lactoglobulin mutant using pulse-labeling H/D exchange

Yagi M., Kameda A., Sakurai K., Nishimura C., Goto Y.

Seibutsu Butsuri　Vol. 45　2005

Characterization of alpha-crystallin aggregate of lens from elderly donors

Noriko Fujii, Yoshiari Shimmyo, Miyo Sakai, Yutaka Sadakane, Tooru Nakamura, Tadatoshi Kinouchi, Yuji Goto, Yukio Morimoto, Kirsten Lampi

第78回日本生化学会大会　2005

Stereospecific amyloid-like fibril formation by a peptide fragment of beta(2)-microglobulin

H Wadai, K Yamaguchi, S Takahashi, T Kanno, T Kawai, H Naiki, Y Goto

BIOCHEMISTRY　Vol. 44　No. 1　p. 157-164　2005/01　Research paper (scientific journal)

Direct observation of A beta amyloid fibril growth and inhibition

T Ban, M Hoshino, S Takahashi, D Hamada, K Hasegawa, H Naiki, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 344　No. 3　p. 757-767　2004/11　Research paper (scientific journal)

Conformational stability of amyloid fibrils of beta-microglobulin probed by guanidine-hydrochloride-induced unfolding

T Narimoto, K Sakurai, A Okamoto, E Chatani, M Hoshino, K Hasegawa, H Naiki, Y Goto

FEBS LETTERS　Vol. 576　No. 3　p. 313-319　2004/10　Research paper (scientific journal)

Structure and Formation of Amyloid Fibrils of β_2-Microglobulin

YAMAGUCHI Keiichi, GOTO Yuji

Biophysics　Vol. 44　No. 5　p. 212-217　2004/09/25

Low concentrations of sodium dodecyl sulfate induce the extension of beta(2)-microglobulin-related amyloid fibrils at a neutral pH

S Yamamoto, K Hasegawa, Yamaguchi, I, S Tsutsumi, J Kardos, Y Goto, F Gejyo, H Naiki

BIOCHEMISTRY　Vol. 43　No. 34　p. 11075-11082　2004/08　Research paper (scientific journal)

Core and heterogeneity of beta(2)-microglobulin amyloid fibrils as revealed by H/D exchange

KI Yamaguchi, H Katou, M Hoshino, K Hasegawa, H Naiki, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 338　No. 3　p. 559-571　2004/04　Research paper (scientific journal)

Core structure of amyloid fibril proposed from IR-microscope linear dichroism

H Hiramatsu, Y Goto, H Naiki, T Kitagawa

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 126　No. 10　p. 3008-3009　2004/03　Research paper (scientific journal)

Increase in the conformational flexibility of beta(2)-microglobulin upon copper binding: A possible role for copper in dialysis-related amyloidosis

J Villanueva, M Hoshino, H Katou, J Kardos, K Hasegawa, H Naiki, Y Goto

PROTEIN SCIENCE　Vol. 13　No. 3　p. 797-809　2004/03　Research paper (scientific journal)

2P023 The structure of the interaction part of the amyloid fibril of beta 2 microglobulin elucidated by IR microscope

Lu M., Hiramatsu H., Goto Y., Naiki H., Kitagawa T.

Seibutsu Butsuri　Vol. 44　2004

2P022 Amyloid fibril structure proposed from IR-microscope linear dichroism

Hiramatsu H., Goto Y., Naiki H., Kitagawa T.

Seibutsu Butsuri　Vol. 44　2004

3P022 Helix environment in the early folding intermediate of apomyoglobin detected by time-resolved IR spectroscopy

Nishiguchi S., Goto Y., Takahashi S.

Seibutsu Butsuri　Vol. 44　2004

3P057 Calorimetric analysis of amyloid fibril formation of beta-2-microglobulin

Yamamoto K., Kardos Jozsef, Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 44　2004

3P020 Iso-1-Cytochrome c Folding Studied by a New Method of Single Molecule Detection

Kinoshita M., Goto Y., Takahashi S.

Seibutsu Butsuri　Vol. 44　2004

1P008 Structual Analysis of Amyloid Fibril of Fragment

Iwata K., Fujiwara T., Matsuki Y., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 44　2004

Amyloid fibril structure of beta2-microglobulin #21-31 peptide elucidated by IR-microscope linear dichroism

H Hiramatsu, Y Goto, H Naiki, T Kitagawa

BIOPHYSICAL JOURNAL　Vol. 86　No. 1　p. 505A-505A　2004/01

Glycosaminoglycans enhance the trifluoroethanol-induced extensionof beta(2)-microglobulin-related amyloid fibrils at a neutral pH

S Yamamoto, Yamaguchi, I, K Hasegawa, S Tsutsumi, Y Goto, F Gejyo, H Naiki

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　Vol. 15　No. 1　p. 126-133　2004/01　Research paper (scientific journal)

Direct measurement of the thermodynamic parameters of amyloid formation by isothermal titration calorimetry

Kardos, J, Yamamoto, K, Hasegawa, K, Naiki, H, Goto, Y

J. Biol. Chem　Vol. 279(53)　p. 55308-55314　2004

Optimum amyloid fibril formation of a peptide fragment suggests the amyloidogenic preference of β₂-microglobulin under physiological conditions

Ohhashi, Y, Hasegawa, K, Naiki, H, Goto, Y

J Biol. Chem　Vol. 279(11)　p. 10814-10821　2004

Protein folding by the effects of macromolecular crowding

N Tokuriki, M Kinjo, S Negi, M Hoshino, Y Goto, Urabe, I, T Yomo

PROTEIN SCIENCE　Vol. 13　No. 1　p. 125-133　2004/01　Research paper (scientific journal)

Reversible unfolding of bovine beta-lactoglobulin mutants without a free thiol group

M Yagi, K Sakurai, C Kalidas, CA Batt, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 47　p. 47009-47015　2003/11　Research paper (scientific journal)

Amyloid fibril formation in the context of full-length protein - Effects of proline mutations on the amyloid fibril formation of beta(2)-microglobulin

T Chiba, Y Hagihara, T Higurashi, K Hasegawa, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 47　p. 47016-47024　2003/11　Research paper (scientific journal)

Dissolution of beta(2)-microglobulin amyloid fibrils by dimethylsulfoxide

N Hirota-Nakaoka, K Hasegawa, H Naiki, Y Goto

JOURNAL OF BIOCHEMISTRY　Vol. 134　No. 1　p. 159-164　2003/07　Research paper (scientific journal)

Conformational dynamics of beta(2)-microglobulin analyzed by reduction and reoxidation of the disulfide bond

M Gozu, YH Lee, Y Ohhashi, M Hoshino, H Naiki, Y Goto

JOURNAL OF BIOCHEMISTRY　Vol. 133　No. 6　p. 731-736　2003/06　Research paper (scientific journal)

Structural defects and the diagnosis of amyloidogenic propensity

A Fernandez, J Kardos, LR Scott, Y Goto, RS Berry

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 100　No. 11　p. 6446-6451　2003/05　Research paper (scientific journal)

Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence

T Ban, D Hamada, K Hasegawa, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 19　p. 16462-16465　2003/05　Research paper (scientific journal)

Amyloidogenic synthetic peptides of beta 2-microglobulin - a role of the disulfide bond

K Hasegawa, Y Ohhashi, Yamaguchi, I, N Takahashi, S Tsutsumi, Y Goto, F Gejyo, H Naiki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 304　No. 1　p. 101-106　2003/04　Research paper (scientific journal)

Real time observation of individual beta(2)-microglobulin unfolding and refolding equilibrium using X-ray diffraction

T Higurashi, YC Sasaki, H Naiki, Y Goto

BIOPHYSICAL JOURNAL　Vol. 84　No. 2　p. 166A-166A　2003/02

Protein folding: could hydrophobic collapse be coupled with hydrogen-bond formation?

A Fernandez, J Kardos, Y Goto

FEBS LETTERS　Vol. 536　No. 1-3　p. 187-192　2003/02　Research paper (scientific journal)

NMR analysis of the native and acid denatured β2-microglobulin proline mutants

Kameda A., Hoshino M., Higurashi T., Hagihara Y., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 43　2003

Urea unfolding of ferredoxin-NADP^+ reductase

Tamura K., Maeda M., Hoshino M., Ikegami T., Yamazaki T., Hase T., Goto Y.

Seibutsu Butsuri　Vol. 43　2003

Inhibition of amyloid β peptide (25-35) amyloid fibril extension using L/D isomer chimera peptide

Ban T., Goto Y., Naiki H.

Seibutsu Butsuri　Vol. 43　2003

Various stability of amyloid fibrils formed under different conditions

Okamoto A., Narimoto T., Chatani E., Hoshino M., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 43　2003

Amyloidogenic synthetic peptides of beta2-microglobulin

Hasegawa K., Ohhashi Y., Yamaguchi I., Takahashi N., Tsutsumi S., Goto Y., Gejyo F., Naiki H.

Seibutsu Butsuri　Vol. 43　2003

Amyloid fibril formation and Structural Stability of β2-microgloblin mutants

Kihara M., Hagihara Y., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 43　2003

Effect of Enantiomeric Fragment for Amyloid Fibril Formation

Wadai H., Yamaguchi K., Kanno T., Nakamura T., T. Tomoji, Hasagawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 43　2003

Formation of molten globule-like state of cytochrome c induced by n-alkyl sulfates at low concentrations.

J. Biochem.　Vol. 133　No. 1　p. 93-102　2003

The interaction of beta(2)-glycoprotein I domain V with chaperonin GroEL: The similarity with the domain V and membrane interaction

M Gozu, M Hoshino, T Higurashi, H Kato, Y Goto

PROTEIN SCIENCE　Vol. 11　No. 12　p. 2792-2803　2002/12　Research paper (scientific journal)

The role of disulfide bond in the amyloidogenic state of beta(2)-microglobulin studied by heteronuclear NMR

H Katou, T Kanno, M Hoshino, Y Hagihara, H Tanaka, T Kawai, K Hasegawa, H Naiki, Y Goto

PROTEIN SCIENCE　Vol. 11　No. 9　p. 2218-2229　2002/09　Research paper (scientific journal)

Manipulating monomer-dimer equilibrium of bovine beta-lactoglobulin by amino acid substitution

K Sakurai, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 28　p. 25735-25740　2002/07　Research paper (scientific journal)

Conformation of beta(2)-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond

DP Hong, M Gozu, K Hasegawa, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 24　p. 21554-21560　2002/06　Research paper (scientific journal)

Amyloid fibril formation of beta 2-microglobulin

Y. Goto, M. Hoshino

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 47　No. 6　p. 663-669　2002/05

Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange

M Hoshino, H Katou, Y Hagihara, K Hasegawa, H Naiki, Y Goto

NATURE STRUCTURAL BIOLOGY　Vol. 9　No. 5　p. 332-336　2002/05　Research paper (scientific journal)

Partially folded structure of flavin adenine dinucleotide-depleted ferredoxin-NADP(+) reductase with residual NADP(+) binding domain

M Maeda, D Hamada, M Hoshino, Y Onda, T Hase, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 19　p. 17101-17107　2002/05　Research paper (scientific journal)

Amyloid fibril formation of the mouse V-L domain at acidic pH

SP Martsev, AP Dubnovitsky, AP Vlasov, M Hoshino, K Hasegawa, H Naiki, Y Goto

BIOCHEMISTRY　Vol. 41　No. 10　p. 3389-3395　2002/03　Research paper (scientific journal)

3M1445 Real time observation of individual beta2-microglobulin folding reaction using X-ray diffraction

Higurashi T., Sasaki Y.C., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 42　No. 2　2002

2I615 Conformation of anyloid fibrils studied by nuclear magnetic resonance

Hoshino M., Katou H., Ohhashi Y., Hagihara Y., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 42　No. 2　2002

2I1630 Amyloid fibril formation of beta2-Microglobulin proline mutants

Chiba T., Hagihara Y., Higurashi T., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 42　No. 2　2002

2I1645 Analysis of Structural Stability of beta2-Microglobulin Amyloid Fibris

Narimoto T., Hoshino M., Kardos Jozsef, Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 42　No. 2　2002

2R1615 H/D exchange reaction of ferredoxin-NADP^+ reductase analyzed by NMR

Tamura K., Maeda M., Hoshino M., Yamazaki T., Hase T., Goto Y.

Seibutsu Butsuri　Vol. 42　No. 2　2002

Single molecular observation of conformational change of beta2-microglobulin using FRET and DXT

T Higurashi, YC Sasaki, H Naiki, Y Goto

BIOPHYSICAL JOURNAL　Vol. 82　No. 1　p. 46A-46A　2002/01

Structural analysis of ferredoxin-NADP(+) reductase and substrate complex by nuclear magnetic resonance

M Maeda, M Hoshino, T Yamazaki, T Hase, Y Goto

PLANT AND CELL PHYSIOLOGY　Vol. 43　p. S24-S24　2002

Aggregation of beta(2)-glycoprotein I induced by sodium lauryl sulfate and lysophospholipids

Y Hagihara, DP Hong, M Hoshino, K Enjyoji, H Kato, Y Goto

BIOCHEMISTRY　Vol. 41　No. 3　p. 1020-1026　2002/01　Research paper (scientific journal)

Investigation of a peptide responsible for amyloid fibril formation of beta(2)-microglobulin by Achromobacter protease I

GV Kozhukh, Y Hagihara, T Kawakami, K Hasegawa, H Naiki, Y Goto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 2　p. 1310-1315　2002/01　Research paper (scientific journal)

The intrachain disulfide bond of beta(2)-microglobulin is not essential for the immunoglobulin fold at neutral pH, but is essential for amyloid fibril formation at acidic pH

Y Ohhashi, Y Hagihara, G Kozhukh, M Hoshino, K Hasegawa, Yamaguchi, I, H Naiki, Y Goto

JOURNAL OF BIOCHEMISTRY　Vol. 131　No. 1　p. 45-52　2002/01　Research paper (scientific journal)

Salt-dependent monomer-dimer equilibrium of bovine beta-lactoglobulin at pH 3

K Sakurai, M Oobatake, Y Goto

PROTEIN SCIENCE　Vol. 10　No. 11　p. 2325-2335　2001/11　Research paper (scientific journal)

A two-process model describes the hydrogen exchange behavior of cytochrome c in the molten globule state with various extents of acetylation

Z Szewczuk, Y Konishi, Y Goto

BIOCHEMISTRY　Vol. 40　No. 32　p. 9623-9630　2001/08　Research paper (scientific journal)

Flexible loop of beta(2)-glycoprotein I domain V specifically interacts with hydrophobic ligands

DP Hong, Y Hagihara, H Kato, Y Goto

BIOCHEMISTRY　Vol. 40　No. 27　p. 8092-8100　2001/07　Research paper (scientific journal)

Native-like beta-hairpin retained in the cold-denatured state of bovine beta-lactoglobulin

H Katou, M Hoshino, H Kamikubo, CA Batt, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 310　No. 2　p. 471-484　2001/07　Research paper (scientific journal)

Structural and kinetic characterization of early folding events in beta-lactoglobulin

K Kuwata, R Shastry, H Cheng, M Hoshino, CA Batt, Y Goto, H Roder

NATURE STRUCTURAL BIOLOGY　Vol. 8　No. 2　p. 151-155　2001/02　Research paper (scientific journal)

High pressure NMR reveals a variety of fluctuating conformers in beta-lactoglobulin

K Kuwata, H Li, H Yamada, CA Batt, Y Goto, K Akasaka

JOURNAL OF MOLECULAR BIOLOGY　Vol. 305　No. 5　p. 1073-1083　2001/02　Research paper (scientific journal)

Folding of b-lactoglobulin : nonhierarchic or hierarchic?

Goto Y.

Seibutsu Butsuri　Vol. 41　2001

Stability of beta2-Microgloblin Amyloid Fibrils Analyzed by Depolymerization and Reduction of the Disulfide Bond

Hong D.-P, Hasegawa K, Naiki H, Goto Y

Seibutsu Butsuri　Vol. 41　2001

Role of the intrachain disulfide bond of beta2-microglobulin on its amyloid fibril formation.

Ohashi Y, Hagihara Y, Gennadiy Kozhukh, Hoshino M, Hasegawa K, Yamaguchi I, Naiki H, Kanno T, Kawai T, Goto Y

Seibutsu Butsuri　Vol. 41　2001

The Effect of Alcohol on beta2-Microglobulin Amyloid Fibrils

Hirota-Nakaoka N, Hasegawa K, Naiki H, Goto Y

Seibutsu Butsuri　Vol. 41　2001

Role of disulfide bond in the amyloid fibril formation of beta2-microglobulin by NMR

Katou H, Hoshino M, Gennadiy Kozhukh, Hasegawa K, Naiki H, Goto Y

Seibutsu Butsuri　Vol. 41　2001

Dimerization Interaction of Bovine beta-Lactoglobulin Studied by Amino Acid Substitution.

Sakurai K, Hoshino M, Goto Y

Seibutsu Butsuri　Vol. 41　2001

Real Time Obsevation of beta2-microglobulin Amylolid Fibril Extension

Ban T., Hamada D., Hagihara Y., Chiba T., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 41　2001

Kinetic evidence for non-native A-helix at the N-terminus of B-lactoglobulin

RMC Shastry, H Roder, K Kuwata, Y Goto

BIOPHYSICAL JOURNAL　Vol. 80　No. 1　p. 186A-186A　2001/01

Direct observation of dynamics in cytochrome c by single molecule fluorometry.

T Wazawa, Y Ishii, T Nishida, D Hamada, Y Goto, T Yanagida

BIOPHYSICAL JOURNAL　Vol. 80　No. 1　p. 406A-406A　2001/01

Identification of the phospholipid-binding site of human beta(2)-glycoprotein I domain V by heteronuclear magnetic resonance

M Hoshino, Y Hagihara, Nishii, I, T Yamazaki, H Kato, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 304　No. 5　p. 927-939　2000/12　Research paper (scientific journal)

Control of antibody-antigen interaction using anion-induced conformational change in antigen peptide

Y Katakura, T Miyazaki, H Wada, T Omasa, M Kishimoto, Y Goto, K Suga

PROTEIN ENGINEERING　Vol. 13　No. 10　p. 719-724　2000/10　Research paper (scientific journal)

Conformation and stability of thiol-modified bovine beta-lactoglobulin

K Sakai, K Sakurai, M Sakai, M Hoshino, Y Goto

PROTEIN SCIENCE　Vol. 9　No. 9　p. 1719-1729　2000/09　Research paper (scientific journal)

Is folding of beta-Lactoglobulin non-hierarchic? Intermediate with native-like beta-sheet and non-native alpha-helix

Forge, V, M Hoshino, K Kuwata, M Arai, K Kuwajima, CA Batt, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 296　No. 4　p. 1039-1051　2000/03　Research paper (scientific journal)

The Conformational Stability of Maize Ferredoxin-NADP^+ Reductase Associated with FAD

Maeda M., Hamada D., Onda Y., Hase T., Goto Y.

Seibutsu Butsuri　Vol. 40　2000

Expression of human bete2-microglobulin by Pichia pastoris

Ohhash Y., Hagihara Y., Hoshino I., Yamaguchi I., Hasegawa K., Naiki H., Goto Y.

Seibutsu Butsuri　Vol. 40　2000

Analysis of reversible self-assocciation of bovine beta-Lactoglobulin : Salt effect and temperature dependency

Sakurai K., Sakai M., Aimoto S., Obatake M., Goto Y.

Seibutsu Butsuri　Vol. 40　2000

High Pressure NMR measurement of prion and beta-lactoglobulin

Kuwata K., Hua L., Goto Y., Akasaka K., James Thomas

Seibutsu Butsuri　Vol. 40　2000

Structural analysis of thiol modified beta-lactoglobulin by using NMR

Kashiwai H., Sakai K., Sakurai K., Hoshino M., Goto Y.

Seibutsu Butsuri　Vol. 40　2000

Interaction of labeled beta-Lactoglobulin with chaperonin GroEL

Sakai K., Yamasaki R., Hoshino H., Kawata Y., Goto Y.

Seibutsu Butsuri　Vol. 40　2000

Transition in cytochrome c conformation observed by single-molecule fluorometry

Wazawa T., Nishida T., Ishii Y., Goto Y., Yanagida T.

Seibutsu Butsuri　Vol. 40　2000

Structural characterization of the cold-denatured state of beta-lactoglobulin

Katou H., Hoshino M., Goto Y.

Seibutsu Butsuri　Vol. 40　2000

Folding intermediate of beta-lactoglobulin

Kuwata K., Goto Y., Hoshino M., Heinrich Roder

Seibutsu Butsuri　Vol. 40　2000

Stability and conformation of beta-lactoglobulin detected by SH titration

Hirota-Nakaoka Nami, Goto Yuji

Seibutsu Butsuri　Vol. 40　2000

High mobility of the phospholipid binding loop of human β2-glycoprotein I domain V revealed by heteronuclear NMR.

J.Mol.Biol.　Vol. 304　No. 5　p. 927-940　2000

Solution structure and dynamics of bovine beta-lactoglobulin A

K Kuwata, M Hoshino, Forge, V, S Era, CA Batt, Y Goto

PROTEIN SCIENCE　Vol. 8　No. 11　p. 2541-2545　1999/11　Research paper (scientific journal)

Single molecular observation of the interaction of GroEL with substrate proteins

R Yamasaki, M Hoshino, T Wazawa, Y Ishii, T Yanagida, Y Kawata, T Higurashi, K Sakai, J Nagai, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 292　No. 5　p. 965-972　1999/10　Research paper (scientific journal)

Clustering of fluorine-substituted alcohols as a factor responsible for their marked effects on proteins and peptides

DP Hong, M Hoshino, R Kuboi, Y Goto

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 121　No. 37　p. 8427-8433　1999/09　Research paper (scientific journal)

Folding process of β-lactoglobulin

Kuwata K., Li H., Yamada H., Hoshino M., Era S., Goto Y., Akasaka K., Batt C. A., Roder H.

Seibutsu Butsuri　Vol. 39　1999

SH titration as a tool for understanding the effect of alcohols

Hirota-Nakaoka N., Goto Y.

Seibutsu Butsuri　Vol. 39　1999

Interaction of DTNB Labeled β-Lactoglobulin with Chaperonin GroEL.

Sakai K., Yamasaki R., Hoshino M., Kawata Y., Goto Y.

Seibutsu Butsuri　Vol. 39　1999

Ligand binding mechanism of β-lactoglobulin

Taguchi M., Hoshino M, Aimoto S., Goto Y.

Seibutsu Butsuri　Vol. 39　1999

An Analysis of Reversible Self-Association Reactions of β-Lactoglobulin by Isothemal Titration Calorimeter

Sakurai K., Aimoto S., Goto Y.

Seibutsu Butsuri　Vol. 39　1999

Single molecular observation of the interaction of GroEL with substrate proteins

Yamasaki T., Sakai K., Hoshino M., Wasawa T., Ishi Y., Kawata Y., Yanagida T., Goto Y.

Seibutsu Butsuri　Vol. 39　1999

タンパク質のフォールディング問題 : 立体構造予測から分子病理まで

桑島 邦博, 後藤 祐児, 木寺 詔紀

生物物理　Vol. 39　1999

Folding of beta-lactoglobulin analyzed by NMR

Hoshino Masaru, Forge Vincent, Kuwata Kazuo, Goto Yuii

Seibutsu Butsuri　Vol. 39　1999

Folding of beta-lactoglobulin, a case of the inconsistency of local and non-local interactions

Y Goto, M Hoshino, K Kuwata, CA Batt

OLD AND NEW VIEWS OF PROTEIN FOLDING　Vol. 1194　p. 3-11　1999　Research paper (international conference proceedings)

Dynamic stability of bovine beta-lactoglobulin studied by hydrogen/deuterium exchange

Forge, V, M Hoshino, K Kuwata, CA Batt, Y Goto

OLD AND NEW VIEWS OF PROTEIN FOLDING　Vol. 1194　p. 13-19　1999　Research paper (international conference proceedings)

Alcohol-induced denaturation of beta-lactoglobulin: A close correlation to the alcohol-induced alpha-helix formation of melittin

N Hirota-Nakaoka, Y Goto

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 7　No. 1　p. 67-73　1999/01　Research paper (scientific journal)

alpha -&gt;beta transition of beta-lactoglobulin as evidenced by heteronuclear NMR

K Kuwata, M Hoshino, S Era, CA Batt, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 283　No. 4　p. 731-739　1998/11　Research paper (scientific journal)

Plasmin can reduce the function of human beta(2) glycoprotein I by cleaving domain V into a nicked form

N Ohkura, Y Hagihara, T Yoshimura, Y Goto, H Kato

BLOOD　Vol. 91　No. 11　p. 4173-4179　1998/06　Research paper (scientific journal)

Folding intermediate of beta-lactoglobulin with non-native alpha-helical conformation

Y Goto, D Hamada, S Segawa

PEPTIDES　p. 96-97　1998　Research paper (international conference proceedings)

Chain-like conformation of heat-denatured ribonuclease A and cytochrome c as evidenced by solution X-ray scattering

Y Hagihara, M Hoshino, D Hamada, M Kataoka, Y Goto

FOLDING & DESIGN　Vol. 3　No. 3　p. 195-201　1998　Research paper (scientific journal)

Group additive contributions to the alcohol-induced alpha-helix formation of melittin: Implication for the mechanism of the alcohol effects on proteins

N Hirota, K Mizuno, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 275　No. 2　p. 365-378　1998/01　Research paper (scientific journal)

High-level expression of bovine beta-lactoglobulin in Pichia pastoris and characterization of its physical properties

TR Kim, Y Goto, N Hirota, K Kuwata, H Denton, SY Wu, L Sawyer, CA Batt

PROTEIN ENGINEERING　Vol. 10　No. 11　p. 1339-1345　1997/11　Research paper (scientific journal)

Trifluoroethanol-induced conformational transition of hen egg-white lysozyme studied by small-angle X-ray scattering

M Hoshino, Y Hagihara, D Hamada, M Kataoka, Y Goto

FEBS LETTERS　Vol. 416　No. 1　p. 72-76　1997/10　Research paper (scientific journal)

Design and characterization of the anion-sensitive coiled-coil peptide

M Hoshino, N Yumoto, S Yoshikawa, Y Goto

PROTEIN SCIENCE　Vol. 6　No. 7　p. 1396-1404　1997/07　Research paper (scientific journal)

The equilibrium intermediate of beta-lactoglobulin with non-native alpha-helical structure

D Hamada, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 269　No. 4　p. 479-487　1997/06　Research paper (scientific journal)

Cooperative alpha-helix formation of beta-lactoglobulin and melittin induced by hexafluoroisopropanol

N Hirota, K Mizuno, Y Goto

PROTEIN SCIENCE　Vol. 6　No. 2　p. 416-421　1997/02　Research paper (scientific journal)

Structural characterization of the molten globule of alpha-lactalbumin by solution X-ray scattering

M Kataoka, K Kuwajima, F Tokunaga, Y Goto

PROTEIN SCIENCE　Vol. 6　No. 2　p. 422-430　1997/02　Research paper (scientific journal)

Formation of protein and peptide-membrane assemblies and membrane fusion

T Yoshimura, K Kameyama, S Aimoto, T Takagi, Y Goto, S Takahashi

FORMATION AND DYNAMICS OF SELF-ORGANIZED STRUCTURES IN SURFACTANTS AND POLYMER SOLUTIONS　Vol. 106　p. 219-222　1997　Research paper (international conference proceedings)

Structure and function of the recombinant fifth domain of human beta(2)-glycoprotein I: Effects of specific cleavage between Lys77 and Thr78

Y Hagihara, K Enjyoji, T Omasa, Y Katakura, K Suga, M Igarashi, E Matsuura, H Kato, T Yoshimura, Y Goto

JOURNAL OF BIOCHEMISTRY　Vol. 121　No. 1　p. 128-137　1997/01　Research paper (scientific journal)

Non-native alpha-helical intermediate in the refolding of beta-lactoglobulin, a predominantly beta-sheet protein

D Hamada, S Segawa, Y Goto

NATURE STRUCTURAL BIOLOGY　Vol. 3　No. 10　p. 868-873　1996/10　Research paper (scientific journal)

Interaction of GroEL with conformational states of horse cytochrome c

M Hoshino, Y Kawata, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 262　No. 4　p. 575-587　1996/10　Research paper (scientific journal)

Role of heme axial ligands in the conformational stability of the native and molten globule states of horse cytochrome c

D Hamada, Y Kuroda, M Kataoka, S Aimoto, T Yoshimura, Y Goto

JOURNAL OF MOLECULAR BIOLOGY　Vol. 256　No. 1　p. 172-186　1996/02　Research paper (scientific journal)

X-ray solution scattering studies of protein folding. (共著)

Folding & Design　Vol. 1　No. 5　1996

High helicity of peptide fragments corresponding to beta-strand regions of beta-lactoglobulin observed by 2D-NMR spectroscopy

Y Kuroda, D Hamada, T Tanaka, Y Goto

FOLDING & DESIGN　Vol. 1　No. 4　p. 255-263　1996　Research paper (scientific journal)

HIGH HELICAL PROPENSITY OF THE PEPTIDE-FRAGMENTS DERIVED FROM BETA-LACTOGLOBULIN, A PREDOMINANTLY BETA-SHEET PROTEIN

D HAMADA, Y KURODA, T TANAKA, Y GOTO

JOURNAL OF MOLECULAR BIOLOGY　Vol. 254　No. 4　p. 737-746　1995/12　Research paper (scientific journal)

Salt-induced formation of the molten globule state of apomyoglobin studied by isothermal titration calorimetry

D Hamada, H Fukada, K Takahashi, Y Goto

THERMOCHIMICA ACTA　Vol. 266　p. 385-400　1995/11　Research paper (scientific journal)

ROLE OF THE N-TERMINAL AND C-TERMINAL DOMAINS OF BOVINE BETA(2)-GLYCOPROTEIN-I IN ITS INTERACTION WITH CARDIOLIPIN

Y HAGIHARA, Y GOTO, H KATO, T YOSHIMURA

JOURNAL OF BIOCHEMISTRY　Vol. 118　No. 1　p. 129-136　1995/07　Research paper (scientific journal)

THERMODYNAMIC STABILITY OF THE MOLTEN GLOBULE STATES OF APOMYOGLOBIN

NISHII, I, M KATAOKA, Y GOTO

JOURNAL OF MOLECULAR BIOLOGY　Vol. 250　No. 2　p. 223-238　1995/07　Research paper (scientific journal)

Structural characterization of the molten globule and native states of apomyoglobin by solution x-ray scattering

Mikio Kataoka, Ichiro Nishii, Tetsuro Fujisawa, Tatzuo Ueki, Fumio Tokunaga, Yuji Goto

Journal of Molecular Biology　Vol. 249　No. 1　p. 215-228　1995/05/26　Research paper (scientific journal)

High helical propensity of the peptide fragments derived from ?-lactoglobulin, a predominantlyβ-sheet protein

D. Hamada, Y. Kuroda, T. Tanaka, Y. Goto

Jour. Mol. Biol.　Vol. 270　p. 1422-1428　1995/04

STRUCTURE AND FUNCTION OF BETA(2)-GLYCOPROTEIN-I - WITH SPECIAL REFERENCE TO THE INTERACTION WITH PHOSPHOLIPID

Y HAGIHARA, Y GOTO, H KATO, T YOSHIMURA

LUPUS　Vol. 4　p. S3-S5　1995/02　Research paper (scientific journal)

Trifluoroethanol-induced Stabilization of the α-Helical Structure of β-Lactoglobulin : Implication for Non-hierarchical Protein Folding. (共著)

┣DBJ. Mol. Biol. (/)-┫DB　Vol. 237　p. 336-348　1995

CLASSIFICATION OF ACID DENATURATION OF PROTEINS - INTERMEDIATES AND UNFOLDED STATES

AL FINK, LJ CALCIANO, Y GOTO, T KUROTSU, DR PALLEROS

BIOCHEMISTRY　Vol. 33　No. 41　p. 12504-12511　1994/10　Research paper (scientific journal)

PERCHLORATE-INDUCED FORMATION OF THE ALPHA-HELICAL STRUCTURE OF MASTOPARAN

M HOSHINO, Y GOTO

JOURNAL OF BIOCHEMISTRY　Vol. 116　No. 4　p. 910-915　1994/10　Research paper (scientific journal)

SALT-INDUCED FORMATION OF THE MOLTEN GLOBULE STATE OF CYTOCHROME-C STUDIED BY ISOTHERMAL TITRATION CALORIMETRY

D HAMADA, SI KIDOKORO, H FUKADA, K TAKAHASHI, Y GOTO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 91　No. 22　p. 10325-10329　1994/10　Research paper (scientific journal)

THERMAL UNFOLDING OF TETRAMERIC MELITTIN - COMPARISON WITH THE MOLTEN GLOBULE STATE OF CYTOCHROME-C

Y HAGIHARA, M OOBATAKE, Y GOTO

PROTEIN SCIENCE　Vol. 3　No. 9　p. 1418-1429　1994/09　Research paper (scientific journal)

COLD DENATURATION OF THE MOLTEN GLOBULE STATES OF APOMYOGLOBIN AND A PROFILE FOR PROTEIN-FOLDING

NISHII, I, M KATAOKA, F TOKUNAGA, Y GOTO

BIOCHEMISTRY　Vol. 33　No. 16　p. 4903-4909　1994/04　Research paper (scientific journal)

COMPARISON OF THE CONFORMATIONAL STABILITY OF THE MOLTEN GLOBULE AND NATIVE STATES OF HORSE CYTOCHROME-C - EFFECTS OF ACETYLATION, HEAT, UREA AND GUANIDINE-HYDROCHLORIDE

Y HAGIHARA, Y TAN, Y GOTO

JOURNAL OF MOLECULAR BIOLOGY　Vol. 237　No. 3　p. 336-348　1994/04　Research paper (scientific journal)

ACID-INDUCED FOLDING OF HEME-PROTEINS

Y GOTO, AL FINK

HEMOGLOBINS, PT C　Vol. 232　p. 3-15　1994

ACID-INDUCED UNFOLDING AND REFOLDING TRANSITIONS OF CYTOCHROME-C - A 3-STATE MECHANISM IN H2O AND D2O

Y GOTO, Y HAGIHARA, D HAMADA, M HOSHINO, NISHII, I

BIOCHEMISTRY　Vol. 32　No. 44　p. 11878-11885　1993/11　Research paper (scientific journal)

INTERMEDIATE CONFORMATIONAL STATES OF APOCYTOCHROME-C

D HAMADA, M HOSHINO, M KATAOKA, AL FINK, Y GOTO

BIOCHEMISTRY　Vol. 32　No. 39　p. 10351-10358　1993/10　Research paper (scientific journal)

CHARACTERIZATION OF THE STABLE, ACID-INDUCED, MOLTEN GLOBULE-LIKE STATE OF STAPHYLOCOCCAL NUCLEASE

AL FINK, LJ CALCIANO, Y GOTO, M NISHIMURA, SA SWEDBERG

PROTEIN SCIENCE　Vol. 2　No. 7　p. 1155-1160　1993/07　Research paper (scientific journal)

GUANIDINE HYDROCHLORIDE-INDUCED FOLDING OF PROTEINS

Y HAGIHARA, S AIMOTO, AL FINK, Y GOTO

JOURNAL OF MOLECULAR BIOLOGY　Vol. 231　No. 2　p. 180-184　1993/05

MOLTEN GLOBULE OF CYTOCHROME-C STUDIED BY SMALL-ANGLE X-RAY-SCATTERING

M KATAOKA, Y HAGIHARA, K MIHARA, Y GOTO

JOURNAL OF MOLECULAR BIOLOGY　Vol. 229　No. 3　p. 591-596　1993/02　Research paper (scientific journal)

Molecular conformation of porcine amelogenin in solution: Three folding units at the N-terminal, central, and C-terminal regions

Yuji Goto, Eiichi Kogure, Toshio Takagi, Saburo Aimoto, Takaaki Aobo

Journal of Biochemistry　Vol. 113　No. 1　p. 55-60　1993　Research paper (scientific journal)

FUSION OF PHOSPHOLIPID-VESICLES INDUCED BY AN AMPHIPHILIC MODEL PEPTIDE - CLOSE CORRELATION BETWEEN FUSOGENICITY AND HYDROPHOBICITY OF THE PEPTIDE IN AN ALPHA-HELIX

T YOSHIMURA, Y GOTO, S AIMOTO

BIOCHEMISTRY　Vol. 31　No. 26　p. 6119-6126　1992/07　Research paper (scientific journal)

Charge Repulsion in the Conformational Stability of Melittin

Yoshihisa Hagihara, Mikio Kataoka, Yuji Goto, Saburo Aimoto

Biochemistry　Vol. 31　No. 47　p. 11908-11914　1992/02/01　Research paper (scientific journal)

MECHANISM OF THE CONFORMATIONAL TRANSITION OF MELITTIN

Y GOTO, Y HAGIHARA

BIOCHEMISTRY　Vol. 31　No. 3　p. 732-738　1992/01　Research paper (scientific journal)

ROLE OF ELECTROSTATIC REPULSION IN THE ACIDIC MOLTEN GLOBULE OF CYTOCHROME-C

Y GOTO, S NISHIKIORI

JOURNAL OF MOLECULAR BIOLOGY　Vol. 222　No. 3　p. 679-686　1991/12　Research paper (scientific journal)

ATP-INDUCED CONFORMATIONAL TRANSITION OF DENATURED PROTEINS

Y GOTO, N OKAMURA, S AIMOTO

JOURNAL OF BIOCHEMISTRY　Vol. 109　No. 5　p. 746-750　1991/05　Research paper (scientific journal)

ANION AND PH-DEPENDENT CONFORMATIONAL TRANSITION OF AN AMPHIPHILIC POLYPEPTIDE

Y GOTO, S AIMOTO

JOURNAL OF MOLECULAR BIOLOGY　Vol. 218　No. 2　p. 387-396　1991/03　Research paper (scientific journal)

PHASE-DIAGRAM FOR ACIDIC CONFORMATIONAL STATES OF APOMYOGLOBIN

Y GOTO, AL FINK

JOURNAL OF MOLECULAR BIOLOGY　Vol. 214　No. 4　p. 803-805　1990/08　Research paper (scientific journal)

MECHANISM OF ACID-INDUCED FOLDING OF PROTEINS

Y GOTO, N TAKAHASHI, AL FINK

BIOCHEMISTRY　Vol. 29　No. 14　p. 3480-3488　1990/04　Research paper (scientific journal)

ACID-INDUCED FOLDING OF PROTEINS

Y GOTO, LJ CALCIANO, AL FINK

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 87　No. 2　p. 573-577　1990/01　Research paper (scientific journal)

CONFORMATIONAL STATES OF BETA-LACTAMASE - MOLTEN-GLOBULE STATES AT ACIDIC AND ALKALINE PH WITH HIGH SALT

Y GOTO, AL FINK

BIOCHEMISTRY　Vol. 28　No. 3　p. 945-952　1989/02　Research paper (scientific journal)

HYDROGEN-EXCHANGE KINETICS OF THE INDOLE NH PROTON OF THE BURIED TRYPTOPHAN IN THE CONSTANT FRAGMENT OF THE IMMUNOGLOBULIN LIGHT CHAIN

Y KAWATA, Y GOTO, K HAMAGUCHI, F HAYASHI, Y KOBAYASHI, Y KYOGOKU

BIOCHEMISTRY　Vol. 27　No. 1　p. 346-350　1988/01　Research paper (scientific journal)

UNFOLDING AND REFOLDING OF A TYPE-K IMMUNOGLOBULIN LIGHT CHAIN AND ITS VARIABLE AND CONSTANT FRAGMENTS

M TSUNENAGA, Y GOTO, Y KAWATA, K HAMAGUCHI

BIOCHEMISTRY　Vol. 26　No. 19　p. 6044-6051　1987/09　Research paper (scientific journal)

CONFORMATION OF THE CONSTANT FRAGMENT OF THE IMMUNOGLOBULIN LIGHT CHAIN - EFFECT OF CLEAVAGE OF THE POLYPEPTIDE-CHAIN AND THE DISULFIDE BOND

Y GOTO, M TSUNENAGA, Y KAWATA, K HAMAGUCHI

JOURNAL OF BIOCHEMISTRY　Vol. 101　No. 2　p. 319-329　1987/02　Research paper (scientific journal)

Monomer-dimer equilibria of a Bence Jones protein and its variable fragment.

J. Biochem.　1978