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CHOONG CHI JING
CHOONG CHI JING
CHOONG CHI JING
CHOONG CHI JING
Institutional repository
Graduate School of Medicine　Division of Medicine, Specially Appointed Researcher (Full Time)
Institutional repository

Papers 30

  1. Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients.

    Kensuke Ikenaka, Yuta Kajiyama, César Aguirre, Chi-Jing Choong, Seira Taniguchi, Junko Doi, Nan Wang, Takahiro Ajiki, Kotaro Ogawa, Keita Kakuda, Yasuyoshi Kimura, Hideki Mochizuki

    Pharmacology research & perspectives　Vol. 12　No. 1　2024/02　Research paper (scientific journal)

  2. Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles

    Keita Kakuda, Kensuke Ikenaka, Akiko Kuma, Junko Doi, César Aguirre, Nan Wang, Takahiro Ajiki, Chi-Jing Choong, Yasuyoshi Kimura, Shaymaa Mohamed Mohamed Badawy, Takayuki Shima, Shuhei Nakamura, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Tamotsu Yoshimori, Hideki Mochizuki

    Proceedings of the National Academy of Sciences　Vol. 121　No. 1　2023/12/26　Research paper (scientific journal)

    Publisher: Proceedings of the National Academy of Sciences

  3. Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.

    Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

    Acta neuropathologica　Vol. 145　No. 5　p. 573-595　2023/03/20　Research paper (scientific journal)

  4. 【Endosome、Lysosome、Exosome-小胞とは?】Exosomeの機能 ミトコンドリアの細胞外放出現象

    和田山 智哉, 奥野 龍禎, Choong Chi-Jing, 望月 秀樹

    Clinical Neuroscience　Vol. 40　No. 7　p. 856-860　2022/07

    Publisher: (株)中外医学社

  5. α-シヌクレインの異常凝集を誘導する脂質の解析

    角田 渓太, Choong Chi-Jing, Aguirre Cesar, 土居 純子, 木村 康義, 池中 建介, 望月 秀樹

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 16回　p. 84-84　2022/07

    Publisher: Movement Disorder Society of Japan (MDSJ)

  6. Neuropathology of α-synuclein in Parkinson's disease.

    Chi-Jing Choong, Hideki Mochizuki

    Neuropathology : official journal of the Japanese Society of Neuropathology　Vol. 42　No. 2　p. 93-103　2022/04　Research paper (scientific journal)

  7. Conformational change in the monomeric alpha-synuclein imparts fibril polymorphs

    Cesar Aguirre, Kensuke Ikenaka, Masatomo So, Takahiro Maruno, Keiichi Yamaguchi, Kichitaro Nakajima, Chi-Jing Choong, Kei Nabekura, Goichi Beck, Kentaro Tomii, Yu Yamamori, Junko Doi, Tomoyasu Matsubara, Maho Morishima, Keita Kakuda, Makoto Hideshima, Yasuyoshi Kimura, Seiichi Nagano, Kousuke Baba, Shigeo Murayama, Hirotsugu Ogi, Yoshitaka Nagai, Yasushi Kawata, Susumu Uchiyama, Yohei Miyanoiri, Yuji Goto, Hideki Mochizuki

    bioRxiv　2022/02/10　Research paper (scientific journal)

    Publisher: Cold Spring Harbor Laboratory

  8. Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.

    Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

    Scientific reports　Vol. 12　No. 1　p. 351-351　2022/01/10　Research paper (scientific journal)

  9. Alternative mitochondrial quality control mediated by extracellular release.

    Chi-Jing Choong, Tatsusada Okuno, Kensuke Ikenaka, Kousuke Baba, Hideki Hayakawa, Masato Koike, Mutsumi Yokota, Junko Doi, Keita Kakuda, Toshihide Takeuchi, Akiko Kuma, Shuhei Nakamura, Yoshitaka Nagai, Seiichi Nagano, Tamotsu Yoshimori, Hideki Mochizuki

    Autophagy　Vol. 17　No. 10　p. 2962-2974　2021/10　Research paper (scientific journal)

    Publisher: Informa UK Limited

  10. Disturbed Mitochondria-Lysosome Crosstalk in GBA1-Associated Parkinson's Disease.

    Chi-Jing Choong, Yasuyoshi Kimura, Hideki Mochizuki

    Movement disorders : official journal of the Movement Disorder Society　Vol. 36　No. 8　p. 1792-1792　2021/08　Research paper (scientific journal)

  11. Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System.

    Shiying Jiang, Kousuke Baba, Tatsusada Okuno, Makoto Kinoshita, Chi-Jing Choong, Hideki Hayakawa, Hiroshi Sakiyama, Kensuke Ikenaka, Seiichi Nagano, Tsutomu Sasaki, Munehisa Shimamura, Yoshitaka Nagai, Keisuke Hagihara, Hideki Mochizuki

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics　Vol. 18　No. 1　p. 460-473　2021/01　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  12. Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.

    Hideki Hayakawa, Rie Nakatani, Kensuke Ikenaka, Cesar Aguirre, Chi-Jing Choong, Hiroshi Tsuda, Seiichi Nagano, Masato Koike, Takeshi Ikeuchi, Masato Hasegawa, Stella M Papa, Yoshitaka Nagai, Hideki Mochizuki, Kousuke Baba

    Movement disorders : official journal of the Movement Disorder Society　Vol. 35　No. 2　p. 256-267　2020/02　Research paper (scientific journal)

  13. Parkinson's disease and iron.

    Hideki Mochizuki, Chi-Jing Choong, Kousuke Baba

    Journal of neural transmission (Vienna, Austria : 1996)　Vol. 127　No. 2　p. 181-187　2020/02　Research paper (scientific journal)

  14. Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein.

    Katsuya Araki, Naoto Yagi, Koki Aoyama, Chi-Jing Choong, Hideki Hayakawa, Harutoshi Fujimura, Yoshitaka Nagai, Yuji Goto, Hideki Mochizuki

    Proceedings of the National Academy of Sciences of the United States of America　Vol. 116　No. 36　p. 17963-17969　2019/09/03　Research paper (scientific journal)

  15. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.

    Takuya Uehara, Chi-Jing Choong, Masayuki Nakamori, Hideki Hayakawa, Kumiko Nishiyama, Yuuya Kasahara, Kousuke Baba, Tetsuya Nagata, Takanori Yokota, Hiroshi Tsuda, Satoshi Obika, Hideki Mochizuki

    Scientific reports　Vol. 9　No. 1　p. 7567-7567　2019/05/21　Research paper (scientific journal)

  16. Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis.

    Satoru Tada, Tatsusada Okuno, Mikito Shimizu, Yoshiki Sakai, Hisae Sumi-Akamaru, Makoto Kinoshita, Kazuya Yamashita, Eri Sanda, Chi-Jing Choong, Akiko Namba, Tsutomu Sasaki, Toru Koda, Kazushiro Takata, Shigeru Miyagawa, Yoshiki Sawa, Yuji Nakatsuji, Hideki Mochizuki

    Scientific reports　Vol. 9　No. 1　p. 5252-5252　2019/03/27　Research paper (scientific journal)

  17. A refined concept: α-synuclein dysregulation disease.

    Hideki Mochizuki, Chi-Jing Choong, Eliezer Masliah

    Neurochemistry international　Vol. 119　p. 84-96　2018/10　Research paper (scientific journal)

  18. New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.

    Yoshiyuki Hirata, Tsutomu Sasaki, Hideaki Kanki, Chi-Jing Choong, Kumiko Nishiyama, Genki Kubo, Ayana Hotei, Masahiko Taniguchi, Hideki Mochizuki, Shinichi Uesato

    Scientific reports　Vol. 8　No. 1　p. 1400-1400　2018/01/23　Research paper (scientific journal)

  19. Gene therapy targeting mitochondrial pathway in Parkinson's disease.

    Chi-Jing Choong, Hideki Mochizuki

    Journal of neural transmission (Vienna, Austria : 1996)　Vol. 124　No. 2　p. 193-207　2017/02　Research paper (scientific journal)

  20. Inappropriate trafficking of damaged mitochondria in Parkinson's disease.

    Chi-Jing Choong, Hideki Mochizuki

    Stem cell investigation　Vol. 4　p. 17-17　2017

  21. 培養細胞系におけるα synuclein伝播、凝集モデルの確立

    早川 英規, 馬場 孝輔, Choong Chi-Jing, 池中 建介, 藪本 大紀, 荒木 克也, 望月 秀樹

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 10回　p. 85-85　2016/10

    Publisher: Movement Disorder Society of Japan (MDSJ)

  22. シヌクレイン凝集阻害薬の大規模スクリーニング系の開発

    池中 建介, 荒木 克哉, 薮本 大紀, Choong Chi-Jing, 早川 英規, 宗 正智, 馬場 孝介, 橋本 真一, 長野 清一, 永井 義隆, 後藤 祐児, 望月 秀樹

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 10回　p. 85-85　2016/10

    Publisher: Movement Disorder Society of Japan (MDSJ)

  23. A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.

    Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, Hideki Mochizuki

    Neurobiology of aging　Vol. 37　p. 103-116　2016/01　Research paper (scientific journal)

  24. Gene therapy for neurological disorders.

    Chi-Jing Choong, Kousuke Baba, Hideki Mochizuki

    Expert opinion on biological therapy　Vol. 16　No. 2　p. 143-59　2016　Research paper (scientific journal)

  25. Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients.

    Katsuya Araki, Naoto Yagi, Yuka Ikemoto, Hisashi Yagi, Chi-Jing Choong, Hideki Hayakawa, Goichi Beck, Hisae Sumi, Harutoshi Fujimura, Taro Moriwaki, Yoshitaka Nagai, Yuji Goto, Hideki Mochizuki

    Scientific reports　Vol. 5　p. 17625-17625　2015/12/01　Research paper (scientific journal)

  26. Parkinson’s disease; neurodegeneration as systemic disease

    Choong Chi-Jing, Hisae Sumi-Akamaru, Hideki Mochizuki

    Neurodegenerative Disorders as Systemic Diseases　p. 69-87　2015/01/01　Part of collection (book)

    Publisher: Springer Japan

  27. Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis.

    Satoru Tada, Tatsusada Okuno, Yasumichi Hitoshi, Teruhito Yasui, Josephe Archie Honorat, Kazushiro Takata, Toru Koda, Hiroshi Shimagami, Choong Chi-Jing, Akiko Namba, Tomoyuki Sugimoto, Saburo Sakoda, Hideki Mochizuki, Hitoshi Kikutani, Yuji Nakatsuji

    Journal of neuroinflammation　Vol. 11　p. 179-179　2014/10/19　Research paper (scientific journal)

  28. The promises of stem cells: stem cell therapy for movement disorders.

    Hideki Mochizuki, Chi-Jing Choong, Toru Yasuda

    Parkinsonism & related disorders　Vol. 20 Suppl 1　2014/01　Research paper (scientific journal)

  29. Neurodegenerative changes initiated by presynaptic dysfunction.

    Toru Yasuda, Yasuto Nakata, Chi-Jing Choong, Hideki Mochizuki

    Translational neurodegeneration　Vol. 2　No. 1　p. 16-16　2013/08/07　Research paper (scientific journal)

  30. Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.

    Chi-Jing Choong, Yee-How Say

    Neurotoxicology　Vol. 32　No. 6　p. 857-63　2011/12　Research paper (scientific journal)

Misc. 5

  1. 野生型及び変異α synuclein凝集体の分子特性に関するin vitro及びin vivoでの比較検討

    早川 英規, 馬場 孝輔, 池中 建介, 仲谷 利栄, Aguirre Cesar, 鐘 其静, 津田 浩史, 長野 清一, 永井 義隆, 池内 健, 望月 秀樹

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集　Vol. 12回　p. 74-74　2018/07

    Publisher: Movement Disorder Society of Japan (MDSJ)

  2. 脳虚血に対するイソ型選択的ヒストンデアセチラーゼ阻害剤の効能と治療成績(Efficacy and implications of isoform selective Histone deacetylase inhibitors for cerebral ischemia)

    佐々木 勉, 鐘 其静, 渡邊 彰弘, 神吉 秀明, 由上 登志郎, 馬場 孝輔, 早川 英規, 平田 佳之, 坂口 学, 上里 新一, 望月 秀樹

    臨床神経学　Vol. 56　No. Suppl.　p. S301-S301　2016/12

    Publisher: (一社)日本神経学会

  3. Novel HDAC1/2 isoform-specific inhibitor K560 ameliorates MPP plus /MPTP-mediated experimental Parkinson's disease

    Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, Hideki Mochizuki

    MOVEMENT DISORDERS　Vol. 31　p. S28-S29　2016/03　Research paper, summary (international conference)

  4. アイソフォーム特異的HDAC阻害剤による虚血性脳血管障害の治療検討

    佐々木 勉, 鐘 其静, 渡邊 彰弘, 神吉 秀明, 馬場 孝輔, 平田 佳之, 坂口 学, 上里 新一, 望月 秀樹

    神経治療学　Vol. 32　No. 5　p. 795-795　2015/09

    Publisher: (一社)日本神経治療学会

  5. Efficacy and Implications of Selective Class I or II Histone Deacetylase Inhibitors for Ischemic Brain Injury

    Tsutomu Sasaki, Chi-Jing Choong, Akihiro Watanabe, Yoshiyuki Hirata, Masato Sanosaka, Kazuo Kitagawa, Hiroshi Takemori, Shinichi Uesato, Hideki Mochizuki

    ANNALS OF NEUROLOGY　Vol. 76　p. S86-S86　2014/10　Research paper, summary (international conference)

Institutional Repository 3

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients

    Ikenaka Kensuke, Kajiyama Yuta, Aguirre César, Choong Chi Jing, Taniguchi Seira, Doi Junko, Wang Nan, Ajiki Takahiro, Ogawa Kotaro, Kakuda Keita, Kimura Yasuyoshi, Mochizuki Hideki

    Pharmacology Research and Perspectives　Vol. 12　No. 1　2024/02/01

  2. Involvement of Mitochondria in Parkinson’s Disease

    Choong Chi Jing, Mochizuki Hideki

    International Journal of Molecular Sciences　Vol. 24　No. 23　2023/12/01

  3. A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson’s disease

    鐘 其静