Developing Thick Cardiac Tissue with a Multilayer Fiber Sheet for Treating Myocardial Infarction

Junjun Li, Xiang Qu, Li Liu, Lingjun Li, Ying Hua, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Nagako Sougawa, Emiko Ito, Noriko Mochizuki-Oda, Akima Harada, Takuji Kawamura, Ryohei Matsuura, Yingzhe Wang, Keisuke Morishima, Shigeru Miyagawa, Yoshiki Sawa

Advanced Fiber Materials　2023/07/31　Research paper (scientific journal)

Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, Hidetaka Kioka, Hisakazu Kato, Hideyuki Hakui, Yuki Saito, Chisato Okamoto, Hijiri Inoue, Jo Hyejin, Kyoko Ueda, Takatsugu Segawa, Shunsuke Nishimura, Yoshihiro Asano, Hiroshi Asanuma, Akiyoshi Tani, Riyo Imamura, Shinsuke Komagawa, Toshio Kanai, Masayuki Takamura, Yasushi Sakata, Masafumi Kitakaze, Jun-ichi Haruta, Seiji Takashima

Circulation　Vol. 147　No. 25　p. 1902-1918　2023/05/02　Research paper (scientific journal)

ONO-1301 enhances post-transplantation survival of human induced pluripotent stem cell-derived cardiac tissue sheet by promoting angiogenesis.

Xiang Qu, Junjun Li, Li Liu, Jingbo Zhang, Ying Hua, Kota Suzuki, Akima Harada, Masako Ishida, Noriko Yoshida, Daisuke Okuzaki, Yoshiki Sakai, Yoshiki Sawa, Shigeru Miyagawa

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation　Vol. 42　No. 6　p. 716-729　2023/02/10　Research paper (scientific journal)

Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier

Satoshi Kameda, Shuichiro Higo, Mikio Shiba, Takumi Kondo, Junjun Li, Li Liu, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Yuki Kuramoto, Hideki Yasutake, Jong-Kook Lee, Seiji Takashima, Yoshihiko Ikeda, Shungo Hikoso, Shigeru Miyagawa, Yasushi Sakata

JACC: Basic to Translational Science　2023/02　Research paper (scientific journal)

Development and evaluation of a novel xeno-free culture medium for human-induced pluripotent stem cells

Ying Hua, Kenji Yoshimochi, Junjun Li, Kazuhiro Takekita, Motoshi Shimotsuma, Lingjun Li, Xiang Qu, Jingbo Zhang, Yoshiki Sawa, Li Liu, Shigeru Miyagawa

Stem Cell Research & Therapy　Vol. 13　No. 1　2022/12　Research paper (scientific journal)

Engineered Tissue for Cardiac Regeneration: Current Status and Future Perspectives

Junjun Li, Li Liu, Jingbo Zhang, Xiang Qu, Takuji Kawamura, Shigeru Miyagawa, Yoshiki Sawa

Bioengineering　Vol. 9　No. 11　p. 605-605　2022/10/22　Research paper (scientific journal)

Tissue Sheet Engineered Using Human Umbilical Cord-Derived Mesenchymal Stem Cells Improves Diabetic Wound Healing

Jingbo Zhang, Xiang Qu, Junjun Li, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Yoshiki Sawa, Li Liu, Shigeru Miyagawa

International Journal of Molecular Sciences　Vol. 23　No. 20　p. 12697-12697　2022/10/21　Research paper (scientific journal)

Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy

Takumi Kondo, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Satoki Nakamura, Maki Takeda, Emiko Ito, Junjun Li, Li Liu, Yuki Kuramoto, Jong-Kook Lee, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Circulation: Genomic and Precision Medicine　2022/07/12　Research paper (scientific journal)

Engineered three-dimensional cardiac tissues maturing in a rotating wall vessel bioreactor remodel diseased hearts in rats with myocardial infarction

Taro Nakazato, Takuji Kawamura, Toshimasa Uemura, Li Liu, Junjun Li, Masao Sasai, Akima Harada, Emiko Ito, Hiroko Iseoka, Koichi Toda, Yoshiki Sawa, Shigeru Miyagawa

Stem Cell Reports　Vol. 17　No. 5　p. 1170-1182　2022/05　Research paper (scientific journal)

Nanocasting of fibrous morphology on a substrate for long-term propagation of human induced pluripotent stem cells.

Sisi Li, Momoko Yoshioka, Junjun Li, Li Liu, Shixin Ye, Ken-Ichiro Kamei, Yong Chen

Biomedical materials (Bristol, England)　Vol. 17　No. 2　2022/02/18　Research paper (scientific journal)

Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes.

Hiroyuki Inoue, Satoki Nakamura, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Takumi Kondo, Satoshi Kameda, Tomoka Tabata, Shota Okuno, Yoshihiko Ikeda, Junjun Li, Li Liu, Satoru Yamazaki, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Stem cell reports　Vol. 17　No. 2　p. 337-351　2022/02/08　Research paper (scientific journal)

Therapeutic efficacy of large aligned cardiac tissue derived from induced pluripotent stem cell in a porcine ischemic cardiomyopathy model.

Kota Suzuki, Shigeru Miyagawa, Li Liu, Takuji Kawamura, Junjun Li, Xiang Qu, Akima Harada, Koichi Toda, Daisuke Yoshioka, Satoshi Kainuma, Ai Kawamura, Yoshiki Sawa

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation　Vol. 40　No. 8　p. 767-777　2021/05/08　Research paper (scientific journal)

Phenotypic Recapitulation and Correction of Desmoglein-2-deficient Cardiomyopathy using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

Mikio Shiba, Shuichiro Higo, Takumi Kondo, Junjun Li, Li Liu, Yoshihiko Ikeda, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Satoki Nakamura, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Human Molecular Genetics　2021/05/05　Research paper (scientific journal)

Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study

Shigeru Miyagawa, Takuji Kawamura, Emiko Ito, Maki Takeda, Hiroko Iseoka, Junya Yokoyama, Akima Harada, Noriko Mochizuki-Oda, Yukiko Imanishi-Ochi, Junjun Li, Masao Sasai, Fumiyo Kitaoka, Masaki Nomura, Naoki Amano, Tomoko Takahashi, Hiromi Dohi, Eiichi Morii, Yoshiki Sawa

2021/04/07

Fabrication of Thick and Anisotropic Cardiac Tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium

Junjun Li, Li Liu, Itsunari Minami, Shigeru Miyagawa, Yoshiki Sawa

Methods in Molecular Biology　Vol. 2320　p. 65-73　2021　Part of collection (book)

Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells

Junjun Li

Scientific Reports　2020/12　Research paper (scientific journal)

Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring

Junjun Li, Lu Zhang, Leqian Yu, Itsunari Minami, Shigeru Miyagawa, Marcel Hörning, Ji Dong, Jing Qiao, Xiang Qu, Ying Hua, Nanae Fujimoto, Yuji Shiba, Yang Zhao, Fuchou Tang, Yong Chen, Yoshiki Sawa, Chao Tang, Li Liu

Communications Biology　Vol. 3　No. 1　p. 122-122　2020/12　Research paper (scientific journal)

hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery.

Junjun Li, Ying Hua, Shigeru Miyagawa, Jingbo Zhang, Lingjun Li, Li Liu, Yoshiki Sawa

International journal of molecular sciences　Vol. 21　No. 23　2020/11/24　Research paper (scientific journal)

Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation

Junjun Li

Advanced Healthcare Materials　2019/05/14　Research paper (scientific journal)

Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells.

Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima M, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K, Tanaka M, Luo C, Tang F, Liu L

Stem cell reports　Vol. 11　No. 1　p. 142-156　2018/06　Research paper (scientific journal)

Isolation and characterization of ventricular-like cells derived from NKX2-5^eGFP/wand MLC2v^mCherry/wdouble knock-in human pluripotent stem cells

Yamauchi, K., Li, J., Morikawa, K., Liu, L., Shirayoshi, Y., Nakatsuji, N., Elliott, D.A., Hisatome, I., Suemori, H.

Biochemical and Biophysical Research Communications　Vol. 495　No. 1　p. 1278-1284　2018　Research paper (scientific journal)

Nano-on-micro fibrous extracellular matrices for scalable expansion of human ES/iPS cells

Liu, L., Kamei, K.-I., Yoshioka, M., Nakajima, M., Li, J., Fujimoto, N., Terada, S., Tokunaga, Y., Koyama, Y., Sato, H., Hasegawa, K., Nakatsuji, N., Chen, Y.

Biomaterials　Vol. 124　2017　Research paper (scientific journal)

Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium

Li, J., Minami, I., Shiozaki, M., Yu, L., Yajima, S., Miyagawa, S., Shiba, Y., Morone, N., Fukushima, S., Yoshioka, M., Li, S., Qiao, J., Li, X., Wang, L., Kotera, H., Nakatsuji, N., Sawa, Y., Chen, Y., Liu, L.

Stem Cell Reports　Vol. 9　No. 5　2017　Research paper (scientific journal)

Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells

Li, J., Zhang, F., Yu, L., Fujimoto, N., Yoshioka, M., Li, X., Shi, J., Kotera, H., Liu, L., Chen, Y.

Journal of Materials Chemistry B　Vol. 5　No. 2　2017　Research paper (scientific journal)

On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure

Li, X., Yu, L., Li, J., Minami, I., Nakajima, M., Noda, Y., Kotera, H., Liu, L., Chen, Y.

Biofabrication　Vol. 8　No. 3　2016　Research paper (scientific journal)

Induction and differentiation of human induced pluripotent stem cells into functional cardiomyocytes on a compartmented monolayer of gelatin nanofibers

Tang, Y., Liu, L., Li, J., Yu, L., Wang, L., Shi, J., Chen, Y.

Nanoscale　Vol. 8　No. 30　2016　Research paper (scientific journal)

Extracellular recordings of patterned human pluripotent stem cell-derived cardiomyocytes on aligned fibers

Li, J., Minami, I., Yu, L., Tsuji, K., Nakajima, M., Qiao, J., Suzuki, M., Shimono, K., Nakatsuji, N., Kotera, H., Liu, L., Chen, Y.

Stem Cells International　Vol. 2016　2016　Research paper (scientific journal)

Effective motor neuron differentiation of hiPSCs on a patch made of crosslinked monolayer gelatin nanofibers

Tang, Y., Liu, L., Li, J., Yu, L., Severino, F.P.U., Wang, L., Shi, J., Tu, X., Torre, V., Chen, Y.

Journal of Materials Chemistry B　Vol. 4　No. 19　2016　Research paper (scientific journal)

3D printing of soft lithography mold for rapid production of polydimethylsiloxane-based microfluidic devices for cell stimulation with concentration gradients

Kamei, K.-I., Mashimo, Y., Koyama, Y., Fockenberg, C., Nakashima, M., Nakajima, M., Li, J., Chen, Y.

Biomedical Microdevices　Vol. 17　No. 2　p. 8-8　2015　Research paper (scientific journal)

Upside and downside views of adherent cells on patterned substrates: Three-dimensional image reconstruction

Li, J. J., Zhou, X. T., Shi, J., Zhang, F., Li, X., Jiang, L. M., Chen, Y.

Microelectronic Engineering　Vol. 110　2013　Research paper (scientific journal)

Microfluidic capture of endothelial progenitor cells in human blood samples

Li, J. J., Broqueres-You, D., Han, Z. T., He, W. T., Li, S. S., Jiang, L. M., Levy, B. I., Shi, J., Chen, Y.

Microelectronic Engineering　Vol. 111　2013　Research paper (scientific journal)

Improved enzyme immobilization for enhanced bioelectrocatalytic activity of choline sensor

Wang, Y., Yu, L., Zhu, Z., Wang, J., Bao, Y., Du, W., Li, J., Peng, H., Zhu, J.

Nanoscience and Nanotechnology Letters　Vol. 5　No. 6　2013　Research paper (scientific journal)

Improved sensing membrane immobilization for enhanced long-term stability of iodide ion-selective microelectrode

Chen, Y., Zhang, J., Wang, Y.-T., Wang, J., Bao, Y.-J., Du, W.-J., Li, J.-J., Peng, H., Zhu, J.-Z.

Nanoscience and Nanotechnology Letters　Vol. 5　No. 6　2013　Research paper (scientific journal)

Facile synthesis of ZnO nanowires on FTO glass for dye-sensitized solar cells

Han, Z., Li, S., Li, J., Chu, J., Chen, Y.

Journal of Semiconductors　Vol. 34　No. 7　2013　Research paper (scientific journal)

A microfluidic device with integrated ZnO nanowires for photodegradation studies of methylene blue under different conditions

Han, Z., Li, J., He, W., Li, S., Li, Z., Chu, J., Chen, Y.

Microelectronic Engineering　Vol. 111　2013　Research paper (scientific journal)

Fabrication of gelatin nanopatterns for cell culture studies

Li, S.S., Shi, J., Liu, L., Li, J.J., Jiang, L.M., Luo, C.X., Kamei, K., Chen, Y.

Microelectronic Engineering　Vol. 110　2013　Research paper (scientific journal)

Preparation of water soluble CdSe and CdSe/CdS quantum dots and their uses in imaging of cell and blood capillary

Bao, Y., Li, J., Wang, Y., Yu, L., Wang, J., Du, W., Lou, L., Zhu, Z., Peng, H., Zhu, J.

Optical Materials　Vol. 34　No. 9　2012　Research paper (scientific journal)

Patterning of Two-Level Topographic Cues for Observation of Competitive Guidance of Cell Alignment

Zhou, Xiongtu, Hu, Jie, Li, Junjun, Shi, Jian, Chen, Yong

Acs Applied Materials & Interfaces　Vol. 4　No. 8　2012　Research paper (scientific journal)

Probing cytotoxicity of CdSe and CdSe/CdS quantum dots

Bao, Y.J., Li, J.J., Wang, Y.T., Yu, L., Lou, L., Du, W.J., Zhu, Z.Q., Peng, H., Zhu, J.Z.

Chinese Chemical Letters　Vol. 22　No. 7　2011　Research paper (scientific journal)

Anisotropic Wet Etched Silicon Substrates for Reoriented and Selective Growth of ZnO Nanowires and Enhanced Hydrophobicity

Li, Sisi, Hu, Jie, Li, Junjun, Tian, Jinghua, Han, Zhitao, Zhou, Xiongtu, Chen, Yong

Langmuir　Vol. 27　No. 11　2011　Research paper (scientific journal)

A compact disk-like centrifugal microfluidic system for high-throughput nanoliter-scale protein crystallization screening

Li, G., Chen, Q., Li, J., Hu, X., Zhao, J.

Analytical Chemistry　Vol. 82　No. 11　2010　Research paper (scientific journal)

Effect of bonding methods on polydimethylsiloxane-based droplet microfluidic devices

Li, J., Chen, Q., Li, G., Zhu, Z., Zhao, J.

Acta Chimica Sinica　Vol. 67　No. 13　2009　Research paper (scientific journal)

Research and application of microfluidics in protein crystallization

Junjun, Li., Qiang, C., Gang, L., Jianlong, Z., Ziqiang, Z.

Progress in Chemistry　Vol. 21　No. 5　2009　Research paper (scientific journal)