keyword Nuclear Magnetic Resonance，Medical Physics
Osaka University
- 1996
Osaka University
- 1996
Osaka University
- 1993
Osaka University School of Pharmaceutical Sciences
- 1991
Osaka University School of Pharmaceutical Sciences
- 1991
日本分析化学会 近畿支部会幹事 Academic society
2013/04 - Present
日本薬学会構造活性相関部会 幹事 Academic society
2006 - Present
日本磁気共鳴医学会 代議員 Academic society
2022/06 - 2025/05
日本核磁気共鳴学会 選挙管理委員 Academic society
2003 -
The Nuclear Magnetic Resonance Society of Japan board of elections Academic society
2003 -
THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY
日本薬学会構造活性相関部会
日本核磁気共鳴学会
日本磁気共鳴医学会
日本薬学会
The Nuclear Magnetic Resonance Society of Japan
The Chemical Society of Japan
Japan Society for Magnetic Resonance in Medicine
Pharmaceutical Society of Japan
Life sciences / Radiology /
Life sciences / Medical biochemistry /
Life sciences / Medical systems /
Life sciences / Biomaterials /
Life sciences / Biomedical engineering /
Scientific Presentation Award
KIMURA Atsuomi 1st AOWPFI & 8th JSPFI 2016/01
Scientific Presentation Award
KIMURA Atsuomi The 3rd meeting of the Japanese Society of Pulmonary Functional Imaging and5th International Workshop for Pulmonary Functional Imaging 2011/01
優秀論文賞
2009
国際飛躍賞
2008
国際飛躍賞
2006
大阪大学大学院医学系研究科保健学専攻優秀論文賞
2006
学術奨励賞
2006
Poster Award
2004
Poster Award
2004
若手ポスター賞
2003
Young Poster Award
2003
Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with Hyperpolarized <sup>129</sup>Xe MR Imaging and Spectroscopy in a Murine Model of Chronic Obstructive Pulmonary Disease
Atsuomi Kimura, Akihiro Shimokawa, Neil J. Stewart, Hirohiko Imai, Hideaki Fujiwara
Magnetic Resonance in Medical Sciences Vol. 24 No. 4 p. n/a-n/a 2025/08 Research paper (scientific journal)
Publisher: Japanese Society for Magnetic Resonance in Medicine
Development of stopped-flow hyper-CEST NMR method on recirculating hyperpolarization system as applied to void space analysis in polymers
Hideaki Fujiwara, Hirohiko Imai, Atsuomi Kimura
Analytical Sciences Vol. 40 No. 12 p. 2269-2278 2024/09/10 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Targeted Imaging of Lung Cancer with Hyperpolarized 129Xe MRI Using Surface-Modified Iron Oxide Nanoparticles as Molecular Contrast Agents
Atsuomi Kimura, Seiya Utsumi, Akihiro Shimokawa, Renya Nishimori, Rie Hosoi, Neil J. Stewart, Hirohiko Imai, Hideaki Fujiwara
Cancers Vol. 14 No. 24 p. 6070-6070 2022/12/09 Research paper (scientific journal)
Publisher: MDPI AG
Quantitative assessment of regional lung ventilation in emphysematous mice using hyperpolarized 129Xe MRI with a continuous flow hyperpolarizing system
Tetsuya Wakayama, Tsuyoshi Ueyama, Fumito Imai, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance Imaging Vol. 92 p. 88-95 2022/10 Research paper (scientific journal)
Publisher: Elsevier BV
Analysis of NMR Adsorption Isotherms of Zeolite ZSM-5: Adsorption Profiles Derived from the Pressure and Temperature Dependences of 129Xe NMR Chemical Shift and Signal Intensity
Hideaki FUJIWARA, Hirohiko IMAI, Yuko ADACHI, Atsuomi KIMURA
Analytical Sciences Vol. 37 No. 12 p. 1803-1810 2021/12/10 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice
Atsuomi Kimura, Seiya Utsumi, Akihiro Shimokawa, Renya Nishimori, Neil J. Stewart, Yoshihiro Kamada, Hirohiko Imai, Hideaki Fujiwara
Contrast Media & Molecular Imaging Vol. 2021 p. 1-10 2021/06/28 Research paper (scientific journal)
Publisher: Hindawi Limited
Multiplexed Xe-129 HyperCEST MRI Detection of Genetically Reconstituted Bacterial Protein Nanoparticles in Human Cancer Cells
Ryota Mizushima, Kanako Inoue, Hideaki Fujiwara, Atsuko H. Iwane, Tomonobu M. Watanabe, Atsuomi Kimura
CONTRAST MEDIA & MOLECULAR IMAGING Vol. 2020 No. 2020 2020/03 Research paper (scientific journal)
Stability Enhancement of (129)Xe Hyperpolarizing System Using Alkali Metal Vapor in Spin-Exchange Optical Pumping Cell to Achieve High NMR Sensitivity.
Fujiwara H, Imai H, Kimura A
Anal Sci Vol. 35 No. 8 p. 869-873 2019/08 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice.
Eriko Fukui, Soichiro Funaki, Kenji Kimura, Toru Momozane, Atsuomi Kimura, Ryota Chijimatsu, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Masato Minami, Shigeru Miyagawa, Yoshiki Sawa, Meinoshin Okumura, Yasushi Shintani
Stem cells international Vol. 2019 No. 10 p. 5179172-5179172 2019 Research paper (scientific journal)
Ethyl Pyruvate Improves Pulmonary Function in Mice with Bleomycin-induced Lung Injury as Monitored with Hyperpolarized <sup>129</sup>Xe MR Imaging
Shota Hodono, Akihiro Shimokawa, Neil J. Stewart, Yukiko Yamauchi, Renya Nishimori, Mami Yamane, Hirohiko Imai, Hideaki Fujiwara, Atsuomi Kimura
Magnetic Resonance in Medical Sciences Vol. 17 No. 4 p. 31-337 2018/10 Research paper (scientific journal)
Publisher: Japanese Society for Magnetic Resonance in Medicine
Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
Hirohiko Imai, Hironobu Yoshimura, Atsuomi Kimura, Hideaki Fujiwara
SCIENTIFIC REPORTS Vol. 7 2017/08 Research paper (scientific journal)
Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized Xe-129 MRI
Atsuomi Kimura, Yukiko Yamauchi, Shota Hodono, Neil James Stewart, Osamu Hosokawa, Yu Hagiwara, Hirohiko Imai, Hideaki Fujiwara
MAGNETIC RESONANCE IN MEDICINE Vol. 78 No. 2 p. 721-729 2017/08 Research paper (scientific journal)
Development and Application of Mouse Imaging Using Hyperpolarized Xenon
H. Imai, A. Kimura, H. Fujiwara
Hyperpolarized and Inert Gas MRI: From Technology to Application in Research and Medicine p. 115-129 2016/11/21 Part of collection (book)
Publisher: Elsevier Inc.
Hyperpolarized Xe-129 MRI using isobutene as a new quenching gas
Shota Hodono, Hirohiko Imai, Yukiko Yamauchi, Ayano Kawamura, Hironobu Matsumoto, Shintaro Okumura, Hideaki Fujiwara, Atsuomi Kimura
NMR IN BIOMEDICINE Vol. 29 No. 10 p. 1414-1419 2016/10 Research paper (scientific journal)
Development and Characterization of Novel LipoCEST Agents Based on Thermosensitive Liposomes
Shuki Maruyama, Junpei Ueda, Atsuomi Kimura, Kenya Murase
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 15 No. 3 p. 324-334 2016 Research paper (scientific journal)
Continuous flow and dissolved phase 129Xe NMR/MRI for quantification in preclinical study as well as materials science
Atsuomi Kimura, Hirohiko Imai, Hideaki Fujiwara
New Developments in NMR Vol. 2015- No. 4 p. 301-316 2015 Research paper (scientific journal)
Publisher: Royal Society of ChemistryRegional fractional ventilation mapping in spontaneously breathing mice using hyperpolarized Xe-129 MRI
Hirohiko Imai, Hironobu Matsumoto, Erika Miyakoshi, Shintaro Okumura, Hideaki Fujiwara, Atsuomi Kimura
NMR IN BIOMEDICINE Vol. 28 No. 1 p. 24-29 2015/01 Research paper (scientific journal)
Small Animal Imaging with Hyperpolarized Xe-129 Magnetic Resonance
Hirohiko Imai, Atsuomi Kimura, Hideaki Fujiwara
ANALYTICAL SCIENCES Vol. 30 No. 1 p. 157-166 2014/01
Validation of Noninvasive Morphological and Diffusion Imaging in Mouse Emphysema by Micro-Computed Tomography and Hyperpolarized Xe-129 Magnetic Resonance Imaging
Satoshi Tetsumoto, Yoshito Takeda, Hirohiko Imai, Atsuomi Kimura, Yingji Jin, Kaori Nakanishi, Yohei Maeda, Hanako Kuhara, Kazuyuki Tsujino, Takeo Iwasaki, Hiroshi Shigeta, Yasushi Kondo, Mari Ito, Toshiyuki Minami, Haruhiko Hirata, Ryo Takahashi, Satoshi Kohmo, Izumi Nagatomo, Koji Inoue, Hiroshi Kida, Takashi Kijima, Isao Tachibana, Norikazu Maeda, Toru Funahashi, Iichiro Shimomura, Hideaki Fujiwara, Atsushi Kumanogoh
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Vol. 49 No. 4 p. 592-600 2013/10 Research paper (scientific journal)
Direct imaging of hyperpolarized 129Xe alveolar gas uptake in a mouse model of emphysema
Satoshi Iguchi, Hirohiko Imai, Yuki Hori, Junichi Nakajima, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance in Medicine Vol. 70 No. 1 p. 207-215 2013/07 Research paper (scientific journal)
Direct Imaging of Alveolar Gas Uptake with Hyperpolarized 129Xe Ultrashort Echo-Time MRI and Its Application to Physiological Assessment of Emphysema in Mouse Lung.
Iguchi S, Imai H, Hori Y, Nakajima J, Kimura A, Fujiwara H
Magn Reson Med 2013/07 Research paper (scientific journal)
Development of a fast method for quantitative measurement of hyperpolarized Xe-129 dynamics in mouse brain
Hirohiko Imai, Atsuomi Kimura, Kazue Akiyama, Chikako Ota, Kazuki Okimoto, Hideaki Fujiwara
NMR IN BIOMEDICINE Vol. 25 No. 2 p. 210-217 2012/02 Research paper (scientific journal)
Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging
Hirohiko Imai, Atsuomi Kimura, Yuki Hori, Satoshi Iguchi, Takuya Kitao, Emi Okubo, Tsuyoshi Ito, Toshio Matsuzaki, Hideaki Fujiwara
NMR IN BIOMEDICINE Vol. 24 No. 10 p. 1343-1352 2011/12 Research paper (scientific journal)
Origin of Dissolved-phase Hyperpolarized Xe-129 Signal in the Mouse Chest Based on Experimental Evidence from Extensive Magnetic Resonance Measurements
Michiko Narazaki, Atsuomi Kimura, Tetsuya Wakayama, Hirohiko Imai, Hideaki Fujiwara
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 10 No. 3 p. 149-154 2011 Research paper (scientific journal)
Origin of dissolved-phase hyperpolarized 129xe signal in the mouse chest based on experimental evidence from extensive magnetic resonance measurements
Michiko Narazaki, Atsuomi Kimura, Tetsuya Wakayama, Hirohiko Imai, Hideaki Fujiwara
Magnetic Resonance in Medical Sciences Vol. 10 No. 3 p. 149-154 2011 Research paper (scientific journal)
Hyperpolarized Xe-129 MR Imaging with Balanced Steady-state Free Precession in Spontaneously Breathing Mouse Lungs
Fumito Imai, Ryosuke Kashiwagi, Hirohiko Imai, Satoshi Iguchi, Atsuomi Kimura, Hideaki Fujiwara
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 10 No. 1 p. 33-40 2011 Research paper (scientific journal)
Noninvasive Detection of Pulmonary Tissue Destruction in a Mouse Model of Emphysema Using Hyperpolarized (129)Xe MRS Under Spontaneous Respiration
Hirohiko Imai, Atsuomi Kimura, Satoshi Iguchi, Yuki Hori, Shoko Masuda, Hideaki Fujiwara
MAGNETIC RESONANCE IN MEDICINE Vol. 64 No. 4 p. 929-938 2010/10 Research paper (scientific journal)
Comprehensive Pulmonary Evaluation of Emphysematous Mice Using Hyperpolarized 129Xe MRI/MRS Under Spontaneous Breathing Mode
H. Imai, A. Kimura, T. Kitao, E. Okubo, Y. Hori, S. Iguchi, H. Fujiwara
Proc. Intl. Soc. Mag. Reson. Med. 2010/05 Research paper (international conference proceedings)
Hyperpolarized Xe-129 dynamic study in mouse lung under spontaneous respiration: Application to murine tumor B16BL6 melanoma
Hirohiko Imai, Atsuomi Kimura, Tsuyoshi Ito, Hideaki Fujiwara
EUROPEAN JOURNAL OF RADIOLOGY Vol. 73 No. 1 p. 196-205 2010/01 Research paper (scientific journal)
3D Hyperpolarized 129Xe MRI of mouse lung at low xenon concentration using a continuous flow-type hyperpolarizing system: feasibility for quantitative measurement of regional ventilation.
Hori Y., Kimura A., Wakayama T., Kitamoto M., Imai F., Imai H., Fujiwara H.
Magn Reson Med Sci Vol. 8 2009 Research paper (scientific journal)
Use of a clinical MRI scanner for preclinical research on rats.
Yamamoto A., Sato H., Enmi J., Ishida K., Ose T., Kimura A., Fujiwara H., Watabe H., Hayashi T., Iida H.
Radiol Phys Technol Vol. 2 2009 Research paper (scientific journal)
A Simple Method for Quantitative Measurement and Analysis of Hyperpolarized 129Xe Uptake Dynamics in Mouse Brain under Controlled-Flow.
Kimura A., Imai H., Wakayama T., Fujiwara H.
Magn Reson Med Sci Vol. 7 2008 Research paper (scientific journal)
Effect of Reduced Pressure on the Polarization of 129Xe in the Production of Hyperpolarized 129Xe Gas: Development of a Simple Continuous Flow Mode Hyperpolarizing System Working at Pressures as Low as 0.15 atm.
Imai H., Fukutomi J., Kimura A., Fujiwara H.
Concepts in Magnetic Resonance Part B Vol. 33 2008 Research paper (scientific journal)
Hyperpolarized 129Xe Phase Selective Imaging of Mouse Lung at 9.4T Using a Continuous Flow-Type Hyperpolarizing System.
Wakayama T., Narazaki M., Kimura A., Fujiwara H.
Magn Reson Med Sci. Vol. 7 2008 Research paper (scientific journal)
Hyperpolarized 129Xe MRI of the Mouse Lung at a Low Xenon Concentration Using a Continuous Flow-Type Hyperpolarizing System.
Wakayama T., Kitamoto M., Ueyama T., Imai H., Narazaki M., Kimura A., Fujiwara H.
J Magn Reson Imag Vol. 27 2008 Research paper (scientific journal)
Inclusion complex formation of thiacalix[4]arene and Xe in aqueous solution studied by hyperpolarized 129Xe NMR
Junko Fukutomi, Yuko Adachi, Akari Kaneko, Atsuomi Kimura, Hideaki Fujiwara
Journal of Inclusion Phenomena and Macrocyclic Chemistry Vol. 58 No. 1-2 p. 115-122 2007/06 Research paper (scientific journal)
Inclusion complex formation of thiacalix[4]arene and Xe in aqueous solution studied by hyperpolarized Xe-129 NMR
Junko Fukutomi, Yuko Adachi, Akari Kaneko, Atsuomi Kimura, Hideaki Fujiwara
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY Vol. 58 No. 1-2 p. 115-122 2007/06 Research paper (scientific journal)
Analysis of Temperature and Pressure Dependence of 129Xe NMR Chemical Shift and Signal Intensity for the Derivation of Basic Parameters of Adsorption as applied to Zeolite ZSM-5.
Kawata Y., Adachi Y., Haga S., Fukutomi J., Imai H., Kimura A., Fujiwara H.
Anal Sci Vol. 23 2007 Research paper (scientific journal)
MR Imaging of Mouse Lung Using Hyperpolarized ^<3>He : Image Acquisition and T_1 Estimation under Spontaneous Respiration
IMAI Hirohiko, NARAZAKI Michiko, INOSHITA Hiroyuki, KIMURA Atsuomi, FUJIWARA Hideaki
MRMS Vol. 5 No. 2 p. 57-64 2006/07/10
Publisher: Japanese Society for Magnetic Resonance in Medicine
Discrimination of enantiomers by means of NMR spectroscopy using chiral liquid crystalline solution: application to triazole fungicides, uniconazole and diniconazole
Makiko Sugiura, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance in Chemistry Vol. 44 No. 2 p. 121-126 2006/02 Research paper (scientific journal)
Publisher: Wiley
Analysis of Hyperpolarized 129Xe Dynamics in Mouse Lungs under Spontaneous Respiration for Separate Determination of Lung Functional Parameters and Relaxation Time
Michiko NARAZAKI, Tetsuya WAKAYAMA, Hirohiko IMAI, Atsuomi KIMURA, Hideaki FUJIWARA
Magnetic Resonance in Medical Sciences Vol. 5 No. 3 p. 119-128 2006 Research paper (scientific journal)
Publisher: Japanese Society for Magnetic Resonance in Medicine
19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement
Atsuomi Kimura, Michiko Narazaki, Yoko Kanazawa, Hideaki Fujiwara
Magnetic Resonance Imaging Vol. 22 No. 6 p. 855-860 2004/07 Research paper (scientific journal)
Publisher: Elsevier BV
MRS of hyperpolarized 129BXe in the chest of mouse—effect of contrast agents on the MRS.
Narazaki M., Wakayama T., Kimura A., Fujiwara H.
Int Cong Ser 1265 Vol. 1265 2004 Research paper (scientific journal)
Hyperpolarized 129Xe as a novel probe agent of lung functions in MRI and MRS. Experimental results with mice at 9.4 T.
Fujiwara H., Kimura A., Wakayama T.
Int Cong Ser 1265 Vol. 2004 2004 Research paper (scientific journal)
MRI and MRS of mouse head at 9.4 T using hyperpolarized Xenon gas.
Wakayama T., Oose T., Narazaki M., Kimura A., Fujiwara H.
Int Cong Ser 1265 2004 Research paper (scientific journal)
Practical application of NMR spectra of 129Xe dissolved in red blood cell
Kawata Y., Kamiya T., Miura H., Kimura A., Fujiwara H.
Int Cong Ser 1265 Vol. 1265 2004 Research paper (scientific journal)
Improvement of T1 Determination of Hyperpolarized 129Xe in Mouse Brain under Controlled-Flow
Atsuomi KIMURA, Tetsuya WAKAYAMA, Michiko NARAZAKI, Yoko KAWATA, Tsuyoshi UEYAMA, Hideaki FUJIWARA
Magnetic Resonance in Medical Sciences Vol. 3 No. 4 p. 199-205 2004 Research paper (scientific journal)
Publisher: Japanese Society for Magnetic Resonance in Medicine
The study of Xe adsorption behavior in meso-size pores of carbon black materials using laser-polarized 129Xe NMR spectroscopy
Koji Saito, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance Imaging Vol. 21 No. 3-4 p. 401-403 2003/04 Research paper (scientific journal)
Publisher: Elsevier BV
Analysis of the effect of foreign gases in the production of hyperpolarized gas on a simple system working under atmospheric pressure
Junko Fukutomi, Eiichi Suzuki, Takahiro Shimizu, Atsuomi Kimura, Hideaki Fujiwara
Journal of Magnetic Resonance Vol. 160 No. 1 p. 26-32 2003/01 Research paper (scientific journal)
Publisher: Elsevier BV
Relaxation Behavior of Laser-Polarized 129Xe Gas: Size Dependency and Wall Effect of the T1 Relaxation Time in Glass and Gelatin Bulbs
Hideaki Fujiwara, Atsuomi Kimura, Yasuhiro Yanagawa, Takashi Kamiya, Mineyuki Hattori, Takashi Hiraga
Journal of Magnetic Resonance Vol. 150 No. 2 p. 156-160 2001/06 Research paper (scientific journal)
Publisher: Elsevier BV
1-1. The Study of Micropores in Coal using Xe and Hyper-Porlaized Xe NMR Sprctroscopy
Saito Koji, Katoh Kenji, Fujiwara Hideaki, Kimura Atsuomi
Proceedings of the Annual Conference of The Japan Institute of Energy Vol. 10 p. 19-22 2001
Publisher: The Japan Institute of Energy
Metabolism of an ionic contrast medium and the related agents
Fumiyo Kasuya, Miyoshi Fukui, Yasuhiro Yanagawa, Atsutomi Kimura, Hideaki Fujiwara
Journal of Chromatography B: Biomedical Sciences and Applications Vol. 746 No. 1 p. 25-31 2000/09 Research paper (scientific journal)
Publisher: Elsevier BV
Conformational Analysis of Quinolines Substituted with Vinyloxyl or Vinylthio Group at the Ortho Position by Means of the NMR Selective Relaxation Method. Experimental Verification of the Planar Structure in Solution
Sugiura M, Vashchenko A. V, Afonin A. V, Kimura A, Fujiwara H
Org Biomol Chem Vol. 2000 p. 1489-1494 2000/07
Specific intramolecular interactions C-H···N in heteroaryl vinyl ethers and heteroaryl vinyl sulfides studied by 1H, 13C, and 15N NMR spectroscopies and by ab initio calculations on molecular structures as well as on nuclear shieldings
Andrei V Afonin, Alexander V Vashchenko, Tatsuya Takagi, Atsuomi Kimura, Hideaki Fujiwara
Canadian Journal of Chemistry Vol. 77 No. 4 p. 416-424 1999/04/01 Research paper (scientific journal)
Publisher: Canadian Science Publishing
Conformational Diversity of [<scp>d</scp>-Pen2,<scp>d</scp>-Pen5]Enkephalin as Studied by Magic-Angle Spinning Liquid-Crystal NMR Spectroscopy and Multiconformational Analysis
Atsuomi Kimura, Kenji Takamoto, Hideaki Fujiwara
Journal of the American Chemical Society Vol. 120 No. 37 p. 9656-9661 1998/09/01 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Preparation and Characterization of Echogenic Liposome as an Ultrasound Contrast Agent: Size-Dependency and Stabilizing Effect of Cholesterol on the Echogenicity of Gas-Entrapping Liposome.
Atsuomi KIMURA, Atsuko SAKAI, Sei-ichi TSUKISHIRO, Shintaro BEPPU, Hideaki FUJIWARA
Chemical and Pharmaceutical Bulletin Vol. 46 No. 10 p. 1493-1496 1998 Research paper (scientific journal)
Publisher: Pharmaceutical Society of Japan
Conformation and Orientation of Met-enkephalin Analogues in a Lyotropic Liquid Crystal Studied by the Magic-Angle- and Near-Magic-Angle-Spinning Two-Dimensional Methodology in Nuclear Magnetic Resonance: Relationships between Activities and Membrane-Associated Structures
Atsuomi Kimura, Naohito Kuni, Hideaki Fujiwara
Journal of the American Chemical Society Vol. 119 No. 20 p. 4719-4725 1997/05/01 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Introduction of Solvent-Accessible Surface Area in the Calculation of the Hydrophobicity Parameter log P from an Atomistic Approach
Takashi Masuda, Takahiro Jikihara, Katsuhiko Nakamura, Atsuomi Kimura, Tatsuya Takagi, Hideaki Fujiwara
Journal of Pharmaceutical Sciences Vol. 86 No. 1 p. 57-63 1997/01 Research paper (scientific journal)
Publisher: American Geophysical Union (AGU)
Unusual Behavior of lon Transport Mediated by Polyene Antibiotics. Activation Energies for the Exchange of Na+ Ions through Liposomal Membranes Studied by 23Na-NMR Spectroscopy.
Atsuomi KIMURA, Naohito KUNI, Hideaki FUJIWARA
Chemical and Pharmaceutical Bulletin Vol. 45 No. 3 p. 431-436 1997 Research paper (scientific journal)
Publisher: Pharmaceutical Society of Japan
Two-Dimensional NMR Study of a Liquid-Crystal Solution under Magic-Angle Spinning. Conformation of Carboxylic Ionophore Lasalocid A Dissolved in a Lyotropic Liquid Crystal
Atsuomi Kimura, Tetsushi Kano, Hideaki Fujiwara
Journal of Magnetic Resonance, Series B Vol. 112 No. 1 p. 44-50 1996/07 Research paper (scientific journal)
Publisher: Elsevier BV
Orientation and Conformation of Met-enkephalin in a Liquid Crystal As Studied by Magic-Angle- and Near-Magic-Angle-Spinning Two-Dimensional NMR Spectroscopy
Atsuomi Kimura, Naohito Kuni, Hideaki Fujiwara
The Journal of Physical Chemistry Vol. 100 No. 33 p. 14056-14061 1996/01/01 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Partition Coefficients in a Liposome/Water System. Methods for Determination and Error Analysis
Tatsuya Takagi, Atsuomi Kimura, Yong-Zhong Da, Hironori Nakai, Hideaki Fujiwara
Analytical Sciences Vol. 8 No. 6 p. 761-765 1992/12 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
An NMR shift reagent method for the determination of micelle/water partition coefficients
Hideaki Fujiwara, Koji Kanzaki, Tetsushi Kano, Atsuomi Kimura, Kyoko Tanaka, Yong-Zhong Da
Journal of the Chemical Society, Chemical Communications No. 10 p. 736-736 1992 Research paper (scientific journal)
Publisher: Royal Society of Chemistry (RSC)
超偏極Xe MRIを用いた 肺気腫に対するピルビン酸エチルの前臨床薬効評価
木村敦臣, 石田賀与, 細井理恵
第53回磁気共鳴医学会大会 2025/08
超偏極キセノンガス生成供給装置を利用した高分子 のナノ空洞解析．広幅化してベースラインとの差が 明確でない弱い信号のhyper-CESTによる検出
藤原英明, 今井宏彦, 木村敦臣
第63回NMR討論会 2024/10/30
酸化鉄ナノ粒子封入リポソームの肺癌への経気道デリバリーと超偏極キセノンMRIによる観察
木村敦臣, 内海誠也, 三木琴音
第52回磁気共鳴医学会大会 2024/09
超偏極キセノンNMR を利用した高分子材料の空洞特性評価の基礎実験． Stopped Flow hyper-CEST 法の開発と応用
藤原 英明, 今井 宏彦, 木村 敦臣
第84回分析化学討論会 2024/05
循環型超偏極キセノンガス生成供給装置を利用したナノ細孔解析． セルロースナノファイバーについて
藤原英明, 今井宏彦, 木村敦臣
第62回NMR討論会 2023/11
表面修飾酸化鉄ナノ粒子を 分子造影剤として使用した超偏極129XeMRIによる 肺癌イメージング
下出 剛史, 三木 琴音, 内海 誠也, 木村 敦臣
第51回日本磁気共鳴医学会大会 2023/09/24
Basic study of lung tumor imaging with hyperpolarized 129Xe MRI using tumor-specific contrast agent
Atsuomi Kimura, Seiya Utsumi, Misaki Miyaoka, Ryoga Moriaki, Hirohiko Imai
2022/09
Fundamental study of lung cancer imaging in hyperpolarized 129Xe MRI using contrast agent
Atsuomi Kimura, Seiya Utsumi, Misaki Miyaoka, Ryoga Moriaki, Seiki Tanimura, Hirohiko Imai
2021/09
Xe-NMR Study of Zeolites. How to enhance the Reliability Adsorption Properties determined by NMR experiments
Hideaki Fujiwara, Hirohiko Imai, Yuko Adachi, Atsuomi Kimura
22nd International Society of Magnetic Resonance Conference 2021/08
Observation of Early Treatment Effect of Ethyl Pyruvate against Lung Cancer by Means of Pulmonary Functional Hyperpolarized 129Xe MRI in Mice
2020/09
頑強で持続可能な超偏極キセノンガス生成供給装置の開発と応用. ナノファイバーのNMR温度可変実験
藤原英明, 小林美一, 今井宏彦, 木村敦臣
第80回日本分析化学討論会 Vol. E1013 2020/05
超偏極129XeMRIを用いた肺がんマウスに対するピルビン酸エチルの薬効評価
西森廉弥, 吉岡佐希子, 内海誠也, 木村敦臣
第12回呼吸機能イメージング研究会学術集会 Vol. P5-1 2020/01
頑強で持続可能な超偏極キセノンガス生成供給装置の開発と応用
藤原英明, 今井宏彦, 木村敦臣
第58回NMR討論会 Vol. L3-1 2019/11
超偏極129Xeを用いた肺がんモデルマウスに対するピルビン酸エチルの薬効評価
内海誠也, 吉岡佐希子, 西森廉弥, 木村敦臣
第47回日本磁気共鳴医学会大会 Vol. P2-A-17 2019/09
超偏極キセノンガス生成供給装置普及版の開発と高分子への応用
藤原英明, 小林美一, 今井宏彦, 木村敦臣
第79回分析化学討論会 Vol. F1009R 2019/05
Molecular imaging of lung cancer with hyperpolarized Xe-129 MRI
R. Nishimori, M. Yamane, A. Shimokawa, N.J. Stewart, H. Imai, A. Kimura
第46回日本磁気共鳴医学会大会 2018/09 Research paper, summary (national, other academic conference)
Multiplexed HyperCEST detection of genetically-reconstituted gas vesicle nanoparticles in human cancer cells in vitro.
水島良太, 井上加奈子, 永井里奈, 岩根敦子, 渡邊朋信, 木村敦臣
第57回NMR討論会 2018/09
超偏極キセノンガス生成供給装置普及版の作成と応用
藤原英明, 今井宏彦, 木村敦臣
第57回NMR討論会 2018/09
超偏極キセノンMRIによる肺線維症の前臨床評価
木村敦臣, 下川晃弘, 程野祥太, 上田ひかり, Neil J. Stewar, 山根麻実, 西森廉弥, 今井宏彦, 藤原英明
第10回呼吸機能イメージング研究会学術集会 2018/02
An Organic Gas instead of Inorganic Gases for the Enhancement of 129Xe Magnetic Resonance Signals through Optical Pumping
Atsuomi Kimura, Hirohiko Imai, Hideaki Fujiwara
2017/05
超偏極NMRによるリアルタイム計測の定量性
服部峰之, 中村和浩, 藤原英明, 木村敦臣
応用物理学会春季学術講演会講演予稿集(CD-ROM) Vol. 64th 2017
超偏極キセノンガスを用いた二次元NMRによるカーボンナノチューブの細孔解析
藤原英明, 木村敦臣, 今井宏彦, 宮脇仁, 尹聖昊, 池田基, 吉鉉植, 出田圭子, 斎藤公児, 金橋康二
第55回NMR討論会 2016/11
循環型超偏極キセノンガスを利用したカーボンナノチューブのNMR分析
斎藤公児, 藤原英明, 木村敦臣, 程野祥太, 今井宏彦, 宮脇仁, 尹聖昊, 池田基, 吉鉉植, 出田圭子, 金橋康二
日本分析化学会第65年会 2016/09
Pulmonary functional imaging using quasi-completely hyperpolarized 129Xe MRI
A. Kimura, A. Shimokawa, S. Hodono, Y. Ozaki, N. Miyazaki, H. Imai, H. Fujiwara
The 27th International Conference on Magnetic Resonance in Biological Systems 2016/08
Evaluation of drug efficacy of ethyl pyruvate on the pulmonary fibrosis in mice with hyperpolarized 129Xe MRI pulmonary function diagnosis
S. Hodono, A. Shimokawa, H. Fujiwara, H. Imai, A. Kimura
1st Asia Oceania Workshop of Pulmonary Functional Imaging combined with 8th Japanese Society of Pulmonary Functional Imaging 2016/01
Relationship between brain and pulmonary function studied by hyperpolarized 129Xe MRI/MRS
A. Shimokawa, H. Matsumoto, Y. Yamaguchi, S. Hodono, S. Okumura, N.J. Stewart, H. Imai, H. Fujiwara, A. Kimura
1st Asia Oceania Workshop of Pulmonary Functional Imaging combined with 8th Japanese Society of Pulmonary Functional Imaging 2016/01
高沸点ガスをクエンチガスとする超偏極129XeMRIの感度増強と肺繊維症診断への応 用
程野 祥太, 今井 宏彦, 山内 紬起子, 下川 晃弘, 野田 雄哉, 上田 ひかり, 藤原 英明, 木村 敦臣
第43回日本磁気共鳴医学会大会 2015/09
超偏極129XeMRI肺機能診断法によるピルビン酸エチルの薬効評価
下川 晃弘, 今井 宏彦, 山内 紬起子, 程野 祥太, 上田 ひかる, 野田 雄哉, 藤原 英明, 木村 敦臣
第43回日本磁気共鳴医学会大会 2015/09
超偏極Xe MRIによる慢性閉塞性肺疾患（COPD）の前臨床評価
木村 敦臣, 山内 紬起子, 奥村 慎太郎, 今井 宏彦, 藤原 英明
第42回構造活性相関シンポジウム 2014/11
多孔質機能性物質の1粒子分析：超偏極129Xeを利用した1粒子スペクトロスコピーと1粒子イメージング
藤原 英明, 今井 宏彦, 武田 和行, 木村 敦臣
第53回NMR討論会 2014/11
超偏極キセノンガス製造供給装置の開発と応用. 高沸点クエンチガスの利用による偏極装置の高性能化
藤原 英明, 今井 宏彦, 木村 敦臣
日本分析化学会第74回分析化学討論会 2014/05
超偏極129XeMRIによる新たなマウス肺気腫評価法確立
鉄本 訓史, 武田 吉人, 金 英姫, 中西 香織, 前田 陽平, 井上 幸治, 長友 泉, 木田 博, 木島 貴志, 立花 功, 熊ノ郷 淳, 今井 宏彦, 木村 敦臣, 近藤 康, 伊藤 真里, 重田 博
日本呼吸器学会誌 Vol. 2 No. 増刊 p. 178-178 2013/03
Publisher: (一社)日本呼吸器学会超偏極129Xe MRIによる肺換気及び血流量の同時評価
松本 浩伸, 奥村 慎太郎, 宮越 友梨佳, 今井 宏彦, 藤原 英明, 木村 敦臣
第5回呼吸機能イメージング研究会学術集会 2013/01
超偏極129Xe MRIによる肺換気及び拡散の同時評価
奥村 慎太郎, 松本 浩伸, 宮越 友梨佳, 今井 宏彦, 藤原 英明, 木村 敦臣
第40回日本磁気共鳴医学会大会 2012/09
超偏極129Xe MRI/MRSを用いた肺・脳機能同時測定
松本 浩伸, 宮越 友梨佳, 奥村 慎太郎, 今井 宏彦, 藤原 英明, 木村 敦臣
第40回日本磁気共鳴医学会大会 2012/09
Imaging of pulmonary ventilation and gas exchange with hyperpolarized 129Xe in mouse models of chronic obstructive pulmonary disease induced by cigarette smoke solution and lipopolysaccharide
H. Imai, H. Matsumoto, Y. Miyakoshi, D. Takemori, S. Nakasone, S. Yamamoto, H. Fujiwara, A. Kimura
International Society for Magnetic Resonance in Medicine 20th Annual Meeting 2012/05
超偏極129Xe MRIによる呼吸機能イメージングの高精細化と病態評価への応用
今井 宏彦, 松本 浩伸, 宮越 友梨佳, 竹森 大智, 仲宗根 進也, 藤原 英明, 木村 敦臣
第4回呼吸機能イメージング研究会学術集会 2012/02
新たな肺機能診断法としての129Xe MRI
鉄本 訓史, 今井 宏彦, 木村 敦臣, 中西 香織, 武田 吉人
第20回Pneumo Forum 2011/11
呼吸同期による超偏極129Xe MRIの高精細化と肺機能評価への応用
今井 宏彦, 松本 浩伸, 宮越 友梨佳, 竹森 大智, 仲宗根 進也, 藤原 英明, 木村 敦臣
第39回日本磁気共鳴医学会大会 2011/09
Quantitative assessment of emphysema with dissolved-phase and gas-phase hyperpolarized 129Xe MRI in mice
H. Imai, A. Kimura, S. Iguchi, H. Fujiwara
International Society for Magnetic Resonance in Medicine 19th Annual Meeting 2011/05
Simultaneous T1 and T2 mapping from inversion recovery TrueFISP experiments for the robust assessment of cardiac functions
H. Fujiwara, Y. Ishikawa, T. Sakuma, N. Yamada, M. Sasagawa, Y. Hori, F. Imai, H. Imai, A. Kimura
International Union of Pure and Applied Chemistry International Congress on Analytical Sciences 2011 2011/05
Development of a novel method for evaluating pulmonary disease using hyperpolarized 129Xe ultrashort echo-time MRI
H. Imai, S. Iguchi, H. Fujiwara, A. Kimura
Joint Meeting Combining The 3rd meeting of the Japanese Society of Pulmonary Functional Imaging and 5th International Workshop for Pulmonary Functional Imaging 2011/01
超偏極129Xe Ultrashort TE MRIによる新規肺疾患診断法の開発
今井 宏彦, 井口 智史, 藤原 英明, 木村 敦臣
第38回日本磁気共鳴医学会大会 2010/09
超偏極129Xe MRI/MRS を用いた肺気腫の包括的な評価
今井 宏彦, 木村 敦臣, 北尾 拓也, 大久保 絵美, 堀 祐樹, 井口 智史, 藤原 英明
第2回呼吸機能イメージング研究会学術集会 2010/01
MR を用いた気道評価: He-3 から Xe-129へ
藤原 英明, 井口 智史, 今井 宏彦, 木村 敦臣
第2回呼吸機能イメージング研究会学術集会 2010/01
129Xe NMRによるゼオライトの吸着特性評価. 銀ゼオライトについて
佐治 修吾, 河田 陽子, 今井 宏彦, 木村 敦臣, 藤原 英明
第48回NMR討論会 2009/11
超偏極129Xe MRIによるマウス肺の高速撮像と機能診断
今井 宏彦, 伊藤 豪, 門林 敏生, 木村 敦臣, 藤原 英明
第37回日本磁気共鳴医学会大会 2009/10
マウス肺超偏極129Xeガス相・溶解相イメージングによる肺機能評価
井口 智史, 今井 宏彦, 堀 祐樹, 木村 敦臣, 藤原 英明
第37回日本磁気共鳴医学会大会 2009/10
Hyperpolarized 129Xe lung MRI with trueFISP on spontaneous breathing mice by means of continuous delivery of Xe gas polarized at low pressure
H. Imai, F. Imai, T. Ito, R. Kashiwagi, T. Kadobayashi, A. Kimura, H. Fujiwara
International Society for Magnetic Resonance in Medicine 17th Scientific Meeting 2009/04
Detection of parameters related to lung function and structure as applied to emphysema model mice with hyperpolarized 129Xe MRS observed under spontaneous respiration
H. Imai, S. Masuda, T. Ito, Y. Hori, A. Kimura, H. Fujiwara
International Society for Magnetic Resonance in Medicine 17th Scientific Meeting 2009/04
3S10p05 Pulmonary functional MRI toward non-invasive preclinical evaluation of drugs
KIMURA Atsuomi
Vol. 21 p. 259-259 2009
Publisher: 日本生物工学会
Use of a clinical MRI scanner for preclinical research on rats
Akihide Yamamoto, Hiroshi Sato, Jun-Ichiro Enmi, Kenji Ishida, Takayuki Ose, Atsuomi Kimura, Hideaki Fujiwara, Hiroshi Watabe, Takuya Hayashi, Hidehiro Iida
Radiological Physics and Technology Vol. 2 No. 1 p. 13-21 2009/01
3D Hyperpolarized Xe-129 MRI of Mouse Lung at Low Xenon Concentration using a Continuous Flow-type Hyperpolarizing System: Feasibility for Quantitative Measurement of Regional Ventilation
Yuki Hori, Atsuomi Kimura, Tetsuya Wakayama, Masakazu Kitamoto, Fumito Imai, Hirohiko Imai, Hideaki Fujiwara
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 8 No. 2 p. 73-79 2009
超偏極129Xe 磁気共鳴法を用いた肺の構造と機能評価 -肺気腫モデル動物への適用-
今井 宏彦, 増田 祥子, 伊藤 豪, 井口 智史, 堀 祐樹, 木村 敦臣, 藤原 英明
第1回呼吸機能イメージング研究会学術集会 2009/01
Magnetic resonance imaging as a means of estimating brain functions: Simultaneous T1 and T2 mapping of human brain by trueFISP sequence
M. Sasagawa, T. Sakuma, N. Yamada, Y. Ishikawa, F. Imai, H. Imai, A. Kimura, H. Fujiwara
8th China-Japan Joint Symposium on Drug Design and Development 2008/11
Magnetic resonance imaging as a means of estimating cardiac functions: Simultaneous T1 and T2 mapping of human heart by trueFISP sequence
Y. Ishikawa, T. Sakuma, N. Yamada, M. Sasagawa, F. Imai, H. Imai, A. Kimura, H. Fujiwara
8th China-Japan Joint Symposium on Drug Design and Development 2008/11
超偏極129Xe MRS を用いたマウス肺の構造と機能評価
今井 宏彦, 増田 祥子, 木村 敦臣, 藤原 英明
第36回日本磁気共鳴医学会大会 2008/09
超偏極129Xe 3D MRI を用いたマウス肺における換気能評価
堀 祐樹, 若山 哲也, 北本 正和, 今井 文人, 今井 宏彦, 木村 敦臣, 藤原 英明
第36回日本磁気共鳴医学会大会 2008/09
Effect of reduced pressure on the polarization of Xe-129 in the production of hyperpolarized Xe-129 gas: Development of a simple continuous flow mode hyperpolarizing system working at pressures as low as 0.15 atm
Hirohiko Imai, Junko Fukutomi, Atsuomi Kimura, Hideaki Fujiwara
CONCEPTS IN MAGNETIC RESONANCE PART B-MAGNETIC RESONANCE ENGINEERING Vol. 33B No. 3 p. 192-200 2008/08
Effect of reduced pressure on the polarization of Xe-129 in the production of hyperpolarized 129Xe gas: Development of a simple continuous flow mode hyperpolarizing system working at pressures as low as 0.15 atm
H. Imai, J. Fukutomi, A. Kimura, H. Fujiwara
International Society for Magnetic Resonance in Medicine 16th Scientific Meeting 2008/05
Hyperpolarized Xe-129 MRI of the mouse lung at a low xenon concentration using a continuous flow-type hyperpolarizing system
Tetsuya Wakayama, Masakazu Kitamoto, Tsuyoshi Ueyama, Hirohiko Imai, Michiko Narazaki, Atsuomi Kimura, Hideaki Fujiwara
JOURNAL OF MAGNETIC RESONANCE IMAGING Vol. 27 No. 4 p. 777-784 2008/04
Hyperpolarized 129Xe phase-selective imaging of mouse lung at 9.4t using a continuous-flow hyperpolarizing system
Tetsuya Wakayama, Michiko Narazaki, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance in Medical Sciences Vol. 7 No. 2 p. 65-72 2008
Hyperpolarized 129Xe dynamic study in mouse lung under spontaneous respiration: Application to murine tumor B16BL6 melanoma
Eur. J. Radiol. Vol. in press 2008
A simple method for quantitative measurement and analysis of hyperpolarized 129Xe uptake dynamics in mouse brain under controlled flow
Atsuomi Kimura, Hirohiko Imai, Tetsuya Wakayama, Hideaki Fujiwara
Magnetic Resonance in Medical Sciences Vol. 7 No. 4 p. 179-185 2008
Analysis of the temperature and pressure dependence of the Xe-129 NMR chemical shift and signal intensity for the derivation of basic parameters of adsorption as applied to zeolite ZSM-5
Yoko Kawata, Yuko Adachi, Saori Haga, Junko Fukutomi, Hirohiko Imai, Atsuomi Kimura, Hideaki Fujiwara
ANALYTICAL SCIENCES Vol. 23 No. 12 p. 1397-1402 2007/12
超偏極キセノンの肺機能診断薬としての利用：肺癌モデルマウスへの適用
今井 宏彦, 伊藤 豪, 木村 敦臣, 藤原 英明
第35回構造活性相関シンポジウム 2007/11
マウス胸部における超偏極129Xe スペクトルダイナミクスの解析 - 肺癌モデルマウスへの適応 -
伊藤 豪, 今井 宏彦, 木村 敦臣, 藤原 英明
第35回日本磁気共鳴医学会大会 2007/09
超偏極129Xe 生成における減圧の効果 - 連続フロー型低圧偏極装置の開発 -
今井 宏彦, 福富 淳子, 木村 敦臣, 藤原 英明
第35回日本磁気共鳴医学会大会 2007/09
Development of novel parameter that reflects Xe transfer rate in mouse lung from hyperpolarized 129Xe dynamic study
H. Imai, T. Ito, A. Kimura, S. Nakagawa, H. Fujiwara
Joint Annual Meeting ISMRM - ESMRMB 2007/05
Evaluating Gas Exchange in the Mouse Lung Using Hyperpolarized ^<129>Xe MRI
UEYAMA Tsuyoshi, WAKAYAMA Tetsuya, KIMURA Atsuomi, FUJIWARA Hideaki
Vol. 27 No. 1 p. 24-26 2007/01/15
Probing Lung Geometry: Measurement of Time-Dependent Diffusion of Hyperpolarized 129Xe in Healthy Mice
Proc. Intl. Soc. Mag. Reson. Med. Vol. 15:1283,2007 2007
Development of Novel Parameter That Reflects Xe Transfer Rate in Mouse Lung from Hyperpolarized 129Xe Dynamic Study Under Spontaneous Respiration: Definition and Application to Murine Tumor B16BL6 Melanoma
Proc. Intl. Soc. Mag. Reson. Med. Vol. 15:1273,2007 2007
3He T1 in mouse lung estimated from washout curve analysis under spontaneous respiration. Use of SF6 gas at thermal equilibrium to evaluate respiratory term
H. Imai, M. Narazaki, H. Inoshita, A. Kimura, H. Fujiwara
International Society for Magnetic Resonance in Medicine 14th Scientific Meeting 2006/05 Research paper, summary (international conference)
Simultaneous observation of lungs and brain to enhance versatility of 129Xe washout curve analysis in mouse brain
H. Fujiwara, T. Masutani, M. Narazaki, H. Imai, T. Wakayama, A. Kimura
International Society for Magnetic Resonance in Medicine 14th Scientific Meeting 2006/05
Discrimination of enantiomers by means of NMR spectroscopy using chiral liquid crystalline solution: application to triazole fungicides, uniconazole and diniconazole
Makiko Sugiura, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance in Chemistry Vol. 44 No. 2 p. 121-126 2006/02
MR Imaging and Spectroscopy of Mouse Lung Using Hyperpolarized 3He: Image Acquisition and T1
Vol. 5, 57-64 2006
Analysis of hyperpolarized 129Xe dynamics in mouse lungs under spontaneous respiration for separate determination of lung functional parameters and relaxation time
Michiko Narazaki, Tetsuya Wakayama, Hirohiko Imai, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance in Medical Sciences Vol. 5 No. 3 p. 119-128 2006
分配係数の差を利用した診断薬・検査薬の開発 (1). 超偏極希ガスの肺機能診断薬としての特性の検討
楢崎 美智子, 今井 宏彦, 若山 哲也, 上山 毅, 木村 敦臣, 藤原 英明
第33回構造活性相関シンポジウム 2005/11
Two-dimensional 129Xe-1H heteronuclear overhauser spectroscopy (HOESY) using laser-polarized 129Xe
J. Fukutomi, Y. Adachi, H. Imai, A. Kimura, H. Fujiwara
1st Asia-Pacific NMR Symposium 2005/11
超偏極 He-3 のMRI/MRS - マウス肺画像の取得と洗い出し曲線からのT1評価
楢崎 美智子, 今井 宏彦, 井下 裕行, 若山 哲也, 上山 毅, 木村 敦臣, 藤原 英明
第33回日本磁気共鳴医学会大会 2005/09
Development of diagnostic agents for lung functions considering the effect of partition coefficient
M. Narazaki, H. Imai, T. Wakayama, T. Ueyama, A. Kimura, H. Fujiwara
7th China-Japan Joint Symposium on Drug Design and Development 2005/09
Estimation of the true relaxation time T1 of hyperpolarized 129Xe gas in mouse lung: Calculation on a ventilation model with the aid of normal gas at thermal equilibrium
M. Narazaki, H. Imai, T. Wakayama, A. Kimura, H. Fujiwara
8th International Conference on Magnetic Resonance Microscopy 2005/08
Handy production of hyperpolarized 3He and MRI of mouse lung
H. Imai, M. Narazaki, H. Inoshita, A. Kimura, H. Fujiwara
8th International Conference on Magnetic Resonance Microscopy 2005/08
Separate Determination of Factors affecting the Hyperpolarized 129Xe Washout Curve observed in Mouse Lungs under Spontaneous Respiration
NARAZAKI M
Proc. Intl. Soc. Mag. Reson. Med. Vol. 13, 1841 2005
Discrimination of enantiomers by means of NMR spectroscopy using chiral liquid crystal solution: application to tiazole fungicides, uniconazole and diniconazol
Magn. Reson. Chem. Vol. 44, 121-126/, 2005
F-19 Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement
A Kimura, M Narazaki, Y Kanazawa, H Fujiwara
MAGNETIC RESONANCE IMAGING Vol. 22 No. 6 p. 855-860 2004/07
MRI and MRS of mouse head at 9.4 T using hyperpolarized Xenon gas
T Wakayama, T Oose, M Narazaki, A Kimura, H Fujiwara
QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI Vol. 167-171 No. 1265 p. 167-171 2004
MRS of hyperpolarized (BXe)-B-129 in the chest of mouse - effect of contrast agents on the MRS
M Narazaki, T Wakayama, A Kimura, H Fujiwara
QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI Vol. 177-180 No. 1265 p. 177-180 2004
Practical application of NMR spectra of Xe-129 dissolved in red blood cell
Y Kawata, T Kamiya, H Miura, A Kimura, H Fujiwara
QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI Vol. 172-176 No. 1265 p. 172-176 2004
Hyperpolarized Xe-129 as a novel probe agent of lung functions in MRI and MRS. Experimental results with mice at 9.4 T
H Fujiwara, A Kimura, T Wakayama
QUANTITATION IN BIOMEDICAL IMAGING WITH PET AND MRI Vol. 124-130 No. 1265 p. 124-130 2004
Improvement of T1 determination of hyperpolarized 129Xe in mouse brain under controlled-flow
Atsuomi Kimura, Tetsuya Wakayama, Michiko Narazaki, Yoko Kawata, Tsuyoshi Ueyama, Hideaki Fujiwara
Magnetic Resonance in Medical Sciences Vol. 3 No. 4 p. 199-205 2004
The study of Xe adsorption behavior in meso-size pores of carbon black materials using laser-polarized Xe-129 NMR spectroscopy
K Saito, A Kimura, H Fujiwara
MAGNETIC RESONANCE IMAGING Vol. 21 No. 3-4 p. 401-403 2003/04
Analysis of the effect of foreign gases in the production of hyperpolarized 129Xe gas on a simple system working under atmospheric pressure
Junko Fukutomi, Eiichi Suzuki, Takahiro Shimizu, Atsuomi Kimura, Hideaki Fujiwara
Journal of Magnetic Resonance Vol. 160 No. 1 p. 26-32 2003
The study of Xe adsorption behavior in meso-size pores of carbon black materials using laser-polarized 129Xe NMR spectroscopy
Koji Saito, Atsuomi Kimura, Hideaki Fujiwara
Magnetic Resonance Imaging Vol. 21 No. 3-4 p. 401-403 2003
Publisher: Elsevier Inc.
Analysis of the effect of foreign gases in the production of hyperpolarized Xe-129 gas on a simple system working under atmospheric pressure
J Fukutomi, E Suzuki, T Shimizu, A Kimura, H Fujiwara
JOURNAL OF MAGNETIC RESONANCE Vol. 160 No. 1 p. 26-32 2003/01
Biological application of Hyperpolarized Noble Gas Magnetic Resonance Imaging
HATTORI Mineyuki, IIDA Hidehiro, KINOSHITA Yoshimasa, HIRAGA Takashi, KIMURA Atsuomi, FUJIWARA Hideaki
Vol. 11 No. 1 p. 2-8 2002/05/01
Relaxation behavior of laser-polarized Xe-129 gas: Size dependency and wall effect of the T-1 relaxation time in glass and gelatin bulbs
H Fujiwara, A Kimura, Y Yanagawa, T Kamiya, M Hattori, T Hiraga
JOURNAL OF MAGNETIC RESONANCE Vol. 150 No. 2 p. 156-160 2001/06
54.超偏極^<129>XeガスのMR測定の経験
木下 良正, 飯田 秀博, 服部 峰之, 木村 敦臣, 藤原 英明
産業医科大学雑誌 Vol. 23 No. 1 p. 121-121 2001/03/01
Publisher: 産業医科大学学会
超偏極129Xeガスによるラット胃のイメージングと緩和特性の研究
柳川 康洋, 木村 敦臣, 木下 良正, 服部 峰之, 平賀 隆, 飯田 秀博, 藤原 英明
日磁医誌, 21, 109 Vol. 21, 109 No. 3 p. 109-118 2001
Publisher: (一社)日本磁気共鳴医学会超偏極129Xeガスによるラット胃のイメージングと緩和特性の研究
柳川 康洋, 木村 敦臣, 木下 良正, 服部 峰之, 平賀 隆, 飯田 秀博, 藤原 英明
日本磁気共鳴医学会雑誌 Vol. 21 No. 3 p. 109-118 2001
Publisher: (一社)日本磁気共鳴医学会Metabolism of an ionic contrast medium and the related agents
F Kasuya, M Fukui, Y Yanagawa, A Kimura, H Fujiwara
JOURNAL OF CHROMATOGRAPHY B Vol. 746 No. 1 p. 25-31 2000/09
Metabolism of an ionic contrast medium and the related agents
F Kasuya, M Fukui, Y Yanagawa, A Kimura, H Fujiwara
JOURNAL OF CHROMATOGRAPHY B Vol. 746 No. 1 p. 25-31 2000/09
超偏極希ガス磁気共鳴イメージング（MRI）の開発－光による核磁気共鳴の飛躍的高感度化を達成－ Development of Hyperpolarized Noble Gas Magnetic Resonance Imaging-Breakthrough in Nuclear Magnetic Resonance Sensitivity by Optical Pumping-
ETL News Vol. 608, 7-12/, 2000
Conformational analyses of quinolines substituted with a vinyloxy or vinylthio group at the ortho position by means of the NMR selective relaxation method. Experimental verification of the planar conformation in solution
M Sugiura, AV Vashchenko, A Kimura, H Fujiwara
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 Vol. 1489-1494 No. 7 p. 1489-1494 2000
Conformatinal Analysis of Quinolines Substituted with a hnyloxy or Vinylthio Group at the Ortho Position by Means of the NMR Selective Relaxation Method. Experimental Verification of the Planar Conformation in Solution
J.Chem.Sec.,Perkin Trans.2 No. 7 p. 1489-1494 2000
Specific intramolecular interactions C-H center dot center dot center dot N in heteroaryl vinyl ethers and heteroaryl vinyl sulfides studied by H-1, C-13, and N-15 NMR spectroscopies and by ab initio calculations on molecular structures as well as on nuclear shieldings
AV Afonin, AV Vashchenko, T Takagi, A Kimura, H Fujiwara
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE Vol. 77 No. 4 p. 416-424 1999/04
Specific intramolecular interactions C-H center dot center dot center dot N in heteroaryl vinyl ethers and heteroaryl vinyl sulfides studied by H-1, C-13, and N-15 NMR spectroscopies and by ab initio calculations on molecular structures as well as on nuclear shieldings
AV Afonin, AV Vashchenko, T Takagi, A Kimura, H Fujiwara
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE Vol. 77 No. 4 p. 416-424 1999/04
Preparation and characterization of echogenic liposome as an ultrasound contrast agent: Size-dependency and stabilizing effect of cholesterol on the echogenicity of gas-entrapping liposome
A Kimura, A Sakai, S Tsukishiro, S Beppu, H Fujiwara
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 46 No. 10 p. 1493-1496 1998/10
Preparation and characterization of echogenic liposome as an ultrasound contrast agent: Size-dependency and stabilizing effect of cholesterol on the echogenicity of gas-entrapping liposome
A Kimura, A Sakai, S Tsukishiro, S Beppu, H Fujiwara
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 46 No. 10 p. 1493-1496 1998/10
Conformational diversity of [D-Pen(2),D-Pen(5)]enkephalin as studied by magic-angle spinning liquid-crystal NMR spectroscopy and multiconformational analysis
A Kimura, K Takamoto, H Fujiwara
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 120 No. 37 p. 9656-9661 1998/09
薬物担体としてのリポソームのＦ－１９ＮＭＲ画像
日磁医誌, 18, 206 Vol. 18, 206 1998
薬物担体としてのリポソームのＦ－１９ＮＭＲ画像
日本磁気共鳴医学会雑誌 Vol. 18,206/, 1998
Conformation and orientation of met-enkephalin analogues in a lyotropic liquid, crystal studied by the magic-angle- and near-magic-angle-spinning two-dimensional methodology in nuclear magnetic resonance: Relationships between activities and membrane-associated structures
A Kimura, N Kuni, H Fujiwara
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 119 No. 20 p. 4719-4725 1997/05
Conformation and orientation of met-enkephalin analogues in a lyotropic liquid, crystal studied by the magic-angle- and near-magic-angle-spinning two-dimensional methodology in nuclear magnetic resonance: Relationships between activities and membrane-associated structures
A Kimura, N Kuni, H Fujiwara
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 119 No. 20 p. 4719-4725 1997/05
Unusual behavior of ion transport mediated by polyene antibiotics. Activation energies for the exchange of Na+ ions through liposomal membranes studied by Na-23-NMR spectroscopy
A Kimura, N Kuni, H Fujiwara
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 45 No. 3 p. 431-436 1997/03
Unusual behavior of ion transport mediated by polyene antibiotics. Activation energies for the exchange of Na+ ions through liposomal membranes studied by Na-23-NMR spectroscopy
A Kimura, N Kuni, H Fujiwara
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 45 No. 3 p. 431-436 1997/03
Introduction of solvent-accessible surface area in the calculation of the hydrophobicity parameter log P from an atomistic approach
T Masuda, T Jikihara, K Nakamura, A Kimura, T Takagi, H Fujiwara
JOURNAL OF PHARMACEUTICAL SCIENCES Vol. 86 No. 1 p. 57-63 1997/01
Orientation and conformation of met-enkephalin in a liquid crystal as studied by magic-angle- and near-magic-angle-spinning two-dimensional NMR spectroscopy
A Kimura, N Kuni, H Fujiwara
JOURNAL OF PHYSICAL CHEMISTRY Vol. 100 No. 33 p. 14056-14061 1996/08
Orientation and conformation of met-enkephalin in a liquid crystal as studied by magic-angle- and near-magic-angle-spinning two-dimensional NMR spectroscopy
A Kimura, N Kuni, H Fujiwara
JOURNAL OF PHYSICAL CHEMISTRY Vol. 100 No. 33 p. 14056-14061 1996/08
Two-dimensional NMR study of a liquid-crystal solution under magic-angle spinning. Conformation of carboxylic ionophore lasalocid a dissolved in a lyotropic liquid crystal
A Kimura, T Kano, H Fujiwara
JOURNAL OF MAGNETIC RESONANCE SERIES B Vol. 112 No. 1 p. 44-50 1996/07
Magic-Angle-Spinning Two-Dimensional NMR for the Study of Conformation of Leucine Enkephalin Oriented in a Lyotropic Liquid Crystal
Vol. 18, 117-118 1996
Magic-Angle-Spinning Two-Dimensional NMR for the Study of Conformation of Leucine Enkephalin Oriented in a Lyotropic Liquid Crystal (jointly worked)
Bull. Magn. Reson. Vol. 18 p. 117-118 1996
PARTITION-COEFFICIENTS IN A LIPOSOME WATER-SYSTEM - METHODS FOR DETERMINATION AND ERROR ANALYSIS
T TAKAGI, A KIMURA, YZ DA, H NAKAI, H FUJIWARA
ANALYTICAL SCIENCES Vol. 8 No. 6 p. 761-765 1992/12
PARTITION-COEFFICIENTS IN A LIPOSOME WATER-SYSTEM - METHODS FOR DETERMINATION AND ERROR ANALYSIS
T TAKAGI, A KIMURA, YZ DA, H NAKAI, H FUJIWARA
ANALYTICAL SCIENCES Vol. 8 No. 6 p. 761-765 1992/12
AN NMR SHIFT-REAGENT METHOD FOR THE DETERMINATION OF MICELLE WATER PARTITION-COEFFICIENTS
H FUJIWARA, K KANZAKI, T KANO, A KIMURA, K TANAKA, YZ DA
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS No. 10 p. 736-737 1992/05
Brain Imaging using Hyperpolarized Xenon MRI., in: M. S. Albert and F. T. Hane, eds., Hyperpolarized and Inert Gas MRI in Research and Medicine
Hane F, Imai H, Kimura A, Fujiwara H, Rao M, Jim JM, Albert M
Elsevier 2017/01 Scholarly book
ISBN: 9780128036754
Development and Application of Mouse Imaging Using Hyperpolarized Xenon, in: M. S. Albert and F. T. Hane, eds., Hyperpolarized and Inert Gas MRI in Research and Medicine
Imai H, Kimura A, Fujiwara H
Elsevier 2017/01 Scholarly book
ISBN: 9780128036754
Continuous Flow and Dissolved Phase 129Xe NMR/MRI for Quantification in Preclinical Study as well as Materials Science, in: T. Meersmann and E. Brunner, eds., Hyperpolarized Xenon-129 Magnetic Resonance
2015/04 Scholarly book
ISBN: 9781849738897
POLARIZED XENON GAS CONCENTRATION METHOD, POLARIZED XENON GAS MANUFACTURING SUPPLY DEVICE, AND MRI SYSTEM.
KIMURA Atsuomi
出願日:2009/07/29
超偏極希ガス生成供給装置
藤原 英明, 木村 敦臣, 今井 宏彦
特許6512724
出願日:2017/12/05
Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with Hyperpolarized ¹²⁹Xe MR Imaging and Spectroscopy in a Murine Model of Chronic Obstructive Pulmonary Disease
Kimura Atsuomi, Shimokawa Akihiro, Stewart Neil J., Imai Hirohiko, Fujiwara Hideaki
Magnetic Resonance in Medical Sciences 2024
Analysis of NMR Adsorption Isotherms of Zeolite ZSM-5: Adsorption Profiles Derived from the Pressure and Temperature Dependences of 129Xe NMR Chemical Shift and Signal Intensity
Fujiwara Hideaki, Imai Hirohiko, Adachi Yuko, Kimura Atsuomi
Analytical Sciences Vol. 37 No. 12 p. 1803-1810 2021/12/10
Stability enhancement of 129Xe hyperpolarizing system using alkali metal vapor in spin-exchange optical pumping cell to achieve high NMR sensitivity
Fujiwara Hideaki, Imai Hirohiko, Kimura Atsuomi
Analytical Sciences Vol. 35 No. 8 p. 869-873 2019/08/10
Data for Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with Hyperpolarized ¹²⁹Xe MR Imaging and Spectroscopy in a Murine Model of Chronic Obstructive Pulmonary Disease
Kimura Atsuomi
マジック角試料回転を利用した液晶二次元NMR法の開発と応用に関する研究
木村 敦臣
