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RNA干渉効率の向上を目指した抗体修飾脂質ナノ粒子の開発
岡田憲明, 岡本彩香, 清水広介, 浅井知浩, 南野哲男, 目加田英輔, 奥直人
日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集 Vol. 24th-2014 2014
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HB‐EGF標的化リポソームの開発
西川薫, 重松宏和, 浅井知浩, 南野哲男, 朝野仁裕, 高島成二, 目加田英輔, 奥直人
日本薬学会年会要旨集 Vol. 130th No. 4 p. 198-198 2010/03/05
Publisher: (公社)日本薬学会
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Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.
Mizushima, H, Wang, X, Miyamoto, S, Mekada, E
J. Cell Sci. Vol. 122 No. 23 p. 4277-4286 2009/11
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体外受精に失敗したマウス未受精卵からの単為発生胚由来ES細胞の樹立とその利用
堀居拓郎, 木村美香, 森田純代, 長尾恭光, 岩本亮, 目加田英輔, 畑田出穂
J Reprod Dev Vol. 55 No. Supplement 2009/08/25
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HB‐EGF標的化リポソームによる新規ターゲティングDDSの開発
重松宏和, 浅井知浩, 南野哲男, 朝野仁裕, 高島成二, 目加田英輔, 奥直人
Drug Delivery System Vol. 24 No. 3 2009/06/09
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RCAS1 induces apoptosis in cells expressing its putative receptor via ectodomain shedding mediated by ADAM9
Kenzo Sonoda, Shingo Miyamoto, Manabu Nakashima, Hiroaki Kobayashi, Eisuke Mekada, Norio Wake
CANCER RESEARCH Vol. 69 2009/05 Research paper, summary (international conference)
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Synergistic antitumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.
Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E, Miyamoto S
Int J Cancer. Vol. 124 No. 6 p. 1429-1439 2009/03
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HB-EGF.
Mekada, E, Iwamoto, R
UCSD-Nature Molecule Pages. 2008/11
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The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice.
Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A
Proc Natl Acad Sci U S A. Vol. 105 No. 35 p. 12921-12926 2008/08
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Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes COPD-like phenotype in mice.
Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, Suzuki M, Minami S, Iwasaki T, Goya S, Kijima T, Kumagai T, Yoshida M, Osaki T, Komori T, Mekada E, Kawase I
J. Biol. Chem. Vol. 283 No. 38 p. 26089-26097 2008/07
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Possible involvement of CD81 in acrosome reaction of sperm in mice.
Tanigawa, M, Miyamoto, K, Kobayashi, S, Sato, M, Akutsu, H, Okabe, M, Mekada, E, Sakakibara, K, Miyado, M, Umezawa, A, Miyado, K
Mol Reprod Dev. Vol. 75 No. 1 p. 150-155 2008/03
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HB-EGF decelerates cell proliferation synergistically with TGF-a in perinatal distal lung development.
Minami, S, Iwamoto, R, Mekada, E
Dev. Dyn. Vol. 237 No. 1 p. 247-258 2008/02
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Validation of HB-EGF and amphiregulin as targets for human cancer therapy.
Yotsumoto, F, Yagi, H, Suzuki, S.O, Oki, E, Tsujioka, H, Hachisuga, T, Sonoda, K, Kawarabayashi, T, Mekada, E, Miyamoto, S
Biochem Biophys Res Commun. Vol. 365 No. 3 p. 555-561 2008/02
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Validation of HB-EGF and amphiregulin as targets for human cancer therapy
Fusanorl Yotsumoto, Hiroshi Yagi, Satoshi O. Suzuki, Eiji Oki, Hiroshi Tsujioka, Touru Hachisuga, Kenzo Sonoda, Tatsuhiko Kawarabayashi, Eisuke Mekada, Shingo Miyamoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 365 No. 3 p. 555-561 2008/01
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HB-EGF decelerates cell proliferation synergistically with TGFα in perinatal distal lung development
Seigo Minami, Ryo Iwamoto, Eisuke Mekada
Developmental Dynamics Vol. 237 No. 1 p. 247-258 2008/01
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Possible involvement of CD81 in acrosome reaction of sperm in mice
Maya Tanigawa, Kiyoko Miyamoto, Satoshi Kobayashi, Masahiro Sato, Hidenori Akutsu, Masaru Okabe, Eisuke Mekada, Keiichi Sakakibara, Mami Miyado, Akihiro Umezawa, Kenji Miyado
MOLECULAR REPRODUCTION AND DEVELOPMENT Vol. 75 No. 1 p. 150-155 2008/01
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Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer
Kenzo Sonoda, Shingo Miyamoto, Ayano Yamazaki, Hiroaki Kobayashi, Manabu Nakashima, Eisuke Mekada, Norio Wake
CANCER Vol. 110 No. 9 p. 1979-1990 2007/11
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Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo
Shinya Oki, Ryuju Hashimoto, Yuko Okui, Michael M. Shen, Eisuke Mekada, Hiroki Otani, Yukio Saijoh, Hiroshi Hamada
DEVELOPMENT Vol. 134 No. 21 p. 3893-3904 2007/11
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Maternal heparin-binding-EGF deficiency limits pregnancy success in mice
Huirong Xie, Haibin Wang, Susanne Tranguch, Ryo Iwamoto, Eisuke Mekada, Francesco J. DeMayo, John P. Lydon, Sanjoy K. Das, Sudhansu K. Dey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 104 No. 46 p. 18315-18320 2007/11
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Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.
Xie, H, Wang, H, Tranguch, S, Iwamoto, R, Mekada, E, DeMayo, F. J, Lydon, J. P, Das S. K, Dey, S. K
Proc. Natl. Acad. Sci. USA Vol. 104 No. 46 p. 18315-18320 2007/09
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Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer.
Sonoda, K, Miyamoto, S, Yamazaki, A, Kobayashi, H, Nakashima, M, Mekada, E, Wake, N
Cancer Vol. 110 No. 9 p. 1979-1990 2007/09
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Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.
Oki, S, Hashimoto, R, Okui, Y, Shen, M.M, Mekada, E, Otani, H, Saijoh, Y, Hamada, H
Development Vol. 134 No. 21 p. 3893-3904 2007/09
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Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.
Kageyama, T, Ohishi, M, Miyamoto, S, Mizushima, H, Iwamoto, R, Mekada, E
J. Biochem. Vol. 142 No. 1 p. 95-104 2007/06
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Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells.
Katayama, H, Kusaka, Y, Yokota, H, Akao, T, Kojima, M, Nakamura, O, Mekada, E, Mizuki. E
J. Biol. Chem. Vol. 282 No. 10 p. 7742-7752 2007/03
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Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells
Hideki Katayama, Yoshitomo Kusaka, Haruo Yokota, Tetsuyuki Akao, Masayasu Kojima, Osamu Nakamura, Eisuke Mekada, Eiich Mizuki
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 282 No. 10 p. 7742-7752 2007/03
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siRNAライブラリーを用いたジフテリア毒素の作用機構に関わる宿主因子の網羅的解析
横田 春生, 大石 美奈子, 目加田 英輔
日本細菌学雑誌 Vol. 62 No. 1 p. 109-109 2007/02/25
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Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.
J. Biochem. Vol. 142 No. 1 p. 95-104 2007
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Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation
Daisuke Nanba, Yumi Kinugasa, Chie Morimoto, Michiko Koizumi, Hisako Yamamura, Katsuhito Takahashi, Nobuyuki Takakura, Eisuke Mekada, Koji Hashimoto, Shigeki Higashiyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 350 No. 2 p. 315-321 2006/11
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Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.
Nanba, D, Kinugasa, Y, Morimoto, C, Koizumi, M, Yamamura, H, Takahashi, K, Takakura, N, Mekada, E, Hashimoto, K, Higashiyama, S
Biochem Biophys Res Commun. Vol. 350 No. 2 p. 315-321 2006/09
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Heparin-binding EGF-like growth factor as a novel targeting molecule for cancer therapy.
Miyamoto, S, Yagi, H, Yotsumoto, F, Kawarabayashi, T, Mekada, E
Cancer Sci. Vol. 97 2006/05
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FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts
K Kakumoto, K Sasai, T Sukezane, C Oneyama, S Ishimaru, K Shibutani, H Mizushima, E Mekada, H Hanafusa, T Akagi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 103 No. 14 p. 5490-5495 2006/04
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FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.
Kakumoto, K, Sasai, K, Sukezane, T, Oneyama, C, Ishimaru, S, Shibutani, K, Mizushima, H, Mekada, E, Hanafusa, H, Akagi, T
Proc. Natl. Acad. Sci. USA Vol. 103 No. 14 p. 5490-5495 2006/04
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Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.
Wang, X, Mizushima, H, Adachi, S, Ohishi, M, Iwamoto, R, Mekada, E
Cell Struct. Funct. Vol. 31 No. 1 p. 15-27 2006/01
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ErbB and HB-EGF signaling in heart development and function.
Iwamoto, R, Mekada, E
Cell Struct. Funct. Vol. 31 No. 1 p. 1-14 2006/01
Publisher: Japan Society for Cell Biology
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"Toxin receptors" in The comprehensive Sourcebook of Bacterial Protein Toxins
Academic Press 2006
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Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor
Xiaobiao Wang, Hiroto Mizushima, Satoshi Adachi, Minako Ohishi, Ryo Iwamoto, Eisuke Mekada
Cell Structure and Function Vol. 31 No. 1 p. 15-27 2006
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ErbB and HB-EGF signaling in heart development and function.
Ryo Iwamoto, Eisuke Mekada
Cell Struct. Funct. Vol. 31 No. 1 p. 1-14 2006
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Heparin-binding EGF-like growth factor as a novel targeting molecule for cancer therapy.
Cancer Sci. Vol. 97 2006
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"Toxin receptors" in The comprehensive Sourcebook of Bacterial Protein Toxins
Academic Press 2006
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HB-EGF promotes epithelial cell migration in eyelid development.
Mine, N, Iwamoto, R, Mekada, E
Development Vol. 132, 4317-4326/, p. 4317-4326 2005/10
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Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.
Kimura, R, Iwamoto, R, Mekada, E
Cell Struct. Funct. Vol. 30 No. 1 p. 35-42 2005/09
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Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.
Tanaka, T, Miyamoto, S, Suzuki, S. O, Oki, E, Yagi, H, Sonoda, K, Yamazaki, A, Mizushima, H, Maehara, Y, Mekada, E, Nakano, H
Clin. Cancer Res. Vol. 11 No. 13 p. 4783-4792 2005/08
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Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer
Y Tanaka, S Miyamoto, SO Suzuki, E Oki, H Yagi, K Sonoda, A Yamazaki, H Mizushima, Y Maehara, E Mekada, H Nakano
CLINICAL CANCER RESEARCH Vol. 11 No. 13 p. 4783-4792 2005/07
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Inhibitory effect of N-acetyl-L-cysteine on TPA-induced shedding of HB-EGF
Toshiyuki Umata, Eisuke Mekada, Toshiyuki Norimura
CELL STRUCTURE AND FUNCTION Vol. 30 p. 83-83 2005/06 Research paper, summary (international conference)
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HB-EGF bioactivity is changed by association with heparan sulfate proteoglycans
Risa Takazaki, Ryo Iwamoto, Eisuke Mekada
CELL STRUCTURE AND FUNCTION Vol. 30 p. 34-34 2005/06 Research paper, summary (international conference)
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Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.
Shirakata, Y, Kimura,K, Nanba, D, Iwamoto, R, Tokumaru, S, Morimoto, C, Yokota, K, Nakamura, M, Sayama, K, Mekada, E, Higashiyama, S, Hashimoto. K
J. Cell Sci. Vol. 118 No. 11 p. 2363-2370 2005/06
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Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing
Y Shirakata, R Kimura, D Nanba, R Iwamoto, S Tokumaru, C Morimoto, K Yokota, M Nakamura, K Sayama, E Mekada, S Higashiyama, K Hashimoto
JOURNAL OF CELL SCIENCE Vol. 118 No. 11 p. 2363-2370 2005/06
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HB-EGF promotes epithelial cell migration in eyelid development
Naoki Mine, Ryo Iwamoto, Eisuke Mekada
CELL STRUCTURE AND FUNCTION Vol. 30 p. 55-55 2005/06 Research paper, summary (international conference)
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Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer
H Yagi, S Miyamoto, Y Tanaka, K Sonoda, H Kobayashi, T Kishikawa, R Iwamoto, E Mekada, H Nakano
BRITISH JOURNAL OF CANCER Vol. 92 No. 9 p. 1737-1745 2005/05
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Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.
Yagi, H, Miyamoto, S, Tanaka, Y, Sonoda, K, Kobayashi, H, Kishikawa, T, Iwamoto, R, Mekada, E, Nakano, H
Brit. J. Cancer Vol. 92 No. 9 p. 1737-1745 2005/05
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Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia
Rina Kimura, Ryo Iwamoto, Eisuke Mekada
Cell Structure and Function Vol. 30 No. 2 p. 35-42 2005
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Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
H Katayama, H Yokota, T Akao, O Nakamura, M Ohba, E Mekada, E Mizuki
JOURNAL OF BIOCHEMISTRY Vol. 137 No. 1 p. 17-25 2005/01
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Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis.
Katayama, H, Yokota, H, Akao, T, Nakamura, O, Ohba, O, Mekada, E, Mizuki, E
J. Biochem. Vol. 137 No. 1 p. 17-25 2005/01
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HB-EGF promotes epithelial cell migration in eyelid development.
Development Vol. 132, 4317-4326 2005
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Mice with defects in HB-EGF and its ectodomain shedding show severe developmental abnormalities
R Iwamoto, S Yamazaki, K Saeki, S Takashima, S Itami, G Yamada, M Klagsbrun, E Mekada
MOLECULAR BIOLOGY OF THE CELL Vol. 15 p. 452A-452A 2004/11 Research paper, summary (international conference)
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Suppression of the biological activities of the epidermal growth factor (EGF)-like domain by the heparin-binding domain of heparin-binding EGF-like growth factor
R Takazaki, Y Shishido, R Iwamoto, E Mekada
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 279 No. 45 p. 47335-47343 2004/11
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Tetraspanin protein (TSP-15) integrity is required for epidermal integrity in Caenorhabditis elegans
H Moribe, J Yochem, H Yamada, Y Tabuse, T Fujimoto, E Mekada
JOURNAL OF CELL SCIENCE Vol. 117 No. 22 p. 5209-5220 2004/10
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Requirement for TSP-15, a tetraspanin protein, for epidermal integrity in Caenorhabditis elegans.
Moribe, H, Yochem, J, Yamada, H, Tabuse, Y, Fujimoto, T, Mekada, E
J. Cell Sci. 2004/10
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Suppression of the biological activities of the EGF-like domain by the heparin-binding domain of heparin-binding EGF-like growth factor.
Takazaki, R, Shishido, Y, Iwamoto, R, Mekada, E
J. Biol. Chem. 2004/10
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Heparin-binding EGF-like growth factor and the LPA-induced ectodomain shedding pathway is a promising target for the therapy of ovarian cancer.
Miyamoto, S, Hirata, M, Yamazaki, A, Kageyama, T, Hasuwa, H, Mizushima, H, Tanaka, Y, Yagi, H, Sonoda, K, Kai, M, Kanoh, H, Nakano, H, Mekada, E
Cancer Res. Vol. 64 No. 16 p. 5720-5727 2004/08
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Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy
S Miyamoto, M Hirata, A Yamazaki, T Kageyama, H Hasuwa, H Mizushima, Y Tanaka, H Yagi, K Sonoda, M Kai, H Kanoh, H Nakano, E Mekada
CANCER RESEARCH Vol. 64 No. 16 p. 5720-5727 2004/08
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Heparin-binding EGF-like Growth Factor Is a Promising Target for the Therapy of Ovarian Cancer
Miyamoto Shingo, Yagi Hiroshi, Tanaka Yoshihiro, Sonoda Kenzo, Nakano Nitoo, Mekata Eisuke
Connective tissue Vol. 36 No. 2 p. 104-104 2004/06/03
Publisher: The Japanese Society for Connective Tissue
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A tetraspanin protein TSP-15 is required for epidermal integrity in C-elegans
Hiroki Moribe, John Yochem, Hiromi Yamada, Yo Tabuse, Toyoshi Fujimoto, Eisuke Mekada
CELL STRUCTURE AND FUNCTION Vol. 29 p. 51-51 2004/05 Research paper, summary (international conference)
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The biological activity of HB-EGF is modulated by its heparin-binding domain and by association with heparan sulfate proteoglycans
Risa Takazaki, Ryo Iwamoto, Eisuke Mekada
CELL STRUCTURE AND FUNCTION Vol. 29 p. 76-76 2004/05 Research paper, summary (international conference)
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TIMP-sensitive proteases are required for HB-EGF-induced tumorigenesis independent of mediating ectodomain shedding
Hiroto Mizushima, Xiobion Wan, Eisuke Mekada
CELL STRUCTURE AND FUNCTION Vol. 29 p. 75-75 2004/05 Research paper, summary (international conference)
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HB-EGF is required for normal cardiac development
Naoki Mine, Ryo Iwamoto, Ikuyo Ishimatu, Eisuke Mekada
CELL STRUCTURE AND FUNCTION Vol. 29 p. 76-76 2004/05 Research paper, summary (international conference)
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Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation.
Ishibashi, T, Ding, L, Ikenaka, K, Inoue, Y, Miyado, K, Mekada, E, Baba, H
J. Neurosci., 24, 96-102. Vol. 24 No. 1 p. 96-102 2004/01
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Suppression of the biological activities of the EGF-like domain by the heparin-binding domain of heparin-binding EGF-like growth factor.
J. Biol. Chem. 2004
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Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation
T Ishibashi, L Ding, K Ikenaka, Y Inoue, K Miyado, E Mekada, H Baba
JOURNAL OF NEUROSCIENCE Vol. 24 No. 1 p. 96-102 2004/01
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Requirement for TSP-15, a tetraspanin protein, for epidermal integrity in Caenorhabditis elegans.
J. Cell Sci. 2004
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Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.
Yamazaki, S, Iwamoto, R, Saeki, K, Asakura, M, Takashima, S, Yamazaki, A, Kimura, R, MIzushima. H, Moribe, H, Higashiyama, S, Endoh, M, Kaneda, Y, Takagi, S, Itami, S, Takeda, N, Yamada, G, Mekada, E
J. Cell Biol., 163, 469-475. Vol. 163 No. 3 p. 469-475 2003/11
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Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities
S Yamazaki, R Iwamoto, K Saeki, M Asakura, S Takashima, A Yamazaki, R Kimura, H Mizushima, H Moribe, S Higashiyama, M Endoh, Y Kaneda, S Takagi, S Itami, N Takeda, G Yamada, E Mekada
JOURNAL OF CELL BIOLOGY Vol. 163 No. 3 p. 469-475 2003/11
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Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
Y Takeda, Tachibana, I, K Miyado, M Kobayashi, T Miyazaki, T Funakoshi, H Kimura, H Yamane, Y Saito, H Goto, T Yoneda, M Yoshida, T Kumagai, T Osaki, S Hayashi, Kawase, I, E Mekada
JOURNAL OF CELL BIOLOGY Vol. 161 No. 5 p. 945-956 2003/06
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Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.
Takeda, Y, Tachibana, I, Miyado, K, Kobayashi, M, Miyazaki, T, Funakoshi, T, Kimura, H, Yamane, H, Saito, Y, Goto, H, Yoneda, T, Yoshida, M, Kumagai, T, Osaki, T, Hayashi, S, Kawase, I, Mekada, E
J. Cell Biol., 161, 945-956. Vol. 161 No. 5 p. 945-956 2003/06
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HB-EGF Is an Essential Growth Factor for Cardiomyocyte Metabolism : The Possibility for a Novel Therapeutic Target for Heart Failure
Takashima Seiji, Kitakaze Masafumi, Asakura Masanori, Mekada Eisuke, Asano Yoshihiro, Shintani Yasunori, Hori Masatsugu
Circulation journal : official journal of the Japanese Circulation Society Vol. 67 p. 11-11 2003/03/01
Publisher: Japanese Circulation Society
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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
R Iwamoto, S Yamazaki, M Asakura, S Takashima, H Hasuwa, K Miyado, S Adachi, M Kitakaze, K Hashimoto, G Raab, D Nanba, S Higashiyama, M Hori, M Klagsbrun, E Mekada
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 100 No. 6 p. 3221-3226 2003/03
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The stress- and the inflammatory cytokine-induced ectodomain shedding of heparin-binding EGF-like growth factor is mediated by p38 MAPK, distinct from TPA-induced and LPA-induced signaling cascades.
Takenobu, H, Yamazaki, A, Hirata, M, Umata, T, Mekada, E
J. Biol. Chem., 278, 17255-17262. Vol. 278, 17255-17262/, 2003/02
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147 Activation of heparin-binding EGF-like Growth factor by various stress(Signal transduction, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) :
UMATA Toshiyuki, TAKENOBU Hisanori, MEKADA Eisuke, NORIMURA Toshiyuki
Journal of radiation research Vol. 44 No. 4 p. 423-423 2003
Publisher: the Japan Radiation Research Society
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The stress- and the inflammatory cytokine-induced ectodomain shedding of heparin-binding EGF-like growth factor is mediated by p38 MAPK, distinct from TPA-induced and LPA-induced signaling cascades.
J. Biol. Chem. Vol. 278, 17255-17262/, 2003
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CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumors
M Kawashima, K Doh-ura, E Mekada, M Fukui, T Iwaki
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY Vol. 50 No. 9 p. 1195-1203 2002/09
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CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumors.
Kawashima, M, Doh-ura, K, Mekada, E, Fukui, M, Iwaki, T
J. Histochem. Cytochem. Vol. 50 No. 9 p. 1195-1203 2002/09
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Ligand-independent dimer formation of EGFR is a step separable from ligand-induced EGFR signaling.
Yu, X, Sharma, K. D, Takahashi, T, Iwamoto, R, Mekada, E
Mol. Biol. Cell Vol. 13 No. 7 p. 2547-2557 2002/07
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Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling
XC Yu, KD Sharma, T Takahashi, R Iwamoto, E Mekada
MOLECULAR BIOLOGY OF THE CELL Vol. 13 No. 7 p. 2547-2557 2002/07
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Elevated cerebrospinal fluid levels of anti-CD9 antibodies in patients with subacute sclerosing panencephalitis.
Shimizu, T, Matsuishi, T, Iwamoto, R, Handa, K, Yoshioka, H, Kato, H, Ueda, S, Hara, H, Tabira, T, Mekada, E
J. Infect. Dis. Vol. 185 No. 9 p. 1346-1350 2002/06
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Elevated levels of anti-CD9 antibodies in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis
T Shimizu, T Matsuishi, R Iwamoto, K Handa, H Yoshioka, H Kato, S Ueda, H Hara, T Tabira, E Mekada
JOURNAL OF INFECTIOUS DISEASES Vol. 185 No. 9 p. 1346-1350 2002/05
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CD9 and gamete membrane fusion(Symposium on the Mechanism of Signal Transduction in Fertilization: its Diversity, Universality and Evolution) :
Miyado Kenji, Okabe Masaru, Mekada Eisuke
Zoological science Vol. 19 No. 12 p. 1409-1410 2002
Publisher: Zoological Society of Japan
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Accelerated signal transduction depending on pre-clustering of epidermal growth factor receptor: A single-molecule analysis
Y Sako, XC Yu, E Mekada, T Yanagida
BIOPHYSICAL JOURNAL Vol. 82 No. 1 p. 217A-217A 2002/01 Research paper, summary (international conference)
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CD9 amino acids critical for upregulation of diphtheria toxin binding.
Hasuwa, H, Shishido, Y, Yamazaki, A, Kobayashi, T, Yu, X, Mekada, E
Biochem. Biophys. Res. Commun. Vol. 289 No. 4 p. 782-790 2001/12
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CD9 amino acids critical for upregulation of diphtheria toxin binding
H Hasuwa, Y Shishido, A Yamazaki, T Kobayashi, XC Yu, E Mekada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 289 No. 4 p. 782-790 2001/12
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Signaling cascade of the ectodomain shedding of HB-EGF
HIRATA Michinari, UMATA Toshiyuki, YU Xiauchu, TAKENOBU Hisanori, MEKADA Eisuke
Vol. 50 p. 87-87 2001/10/01
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Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice
M Saito, T Iwawaki, C Taya, H Yonekawa, M Noda, Y Inui, E Mekada, Y Kimata, A Tsuru, K Kohno
NATURE BIOTECHNOLOGY Vol. 19 No. 8 p. 746-750 2001/08
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A dual signaling cascade that regulates the ectodomain shedding of HB-EGF.
Umata, T, Hirata, M, Takahashi, T, Ryu, F, Shida, S, Takahashi, Y, Tsuneoka, M, Miura, Y, Masuda, M, Horiguchi, Y, Mekada, E
J. Biol. Chem. Vol. 276, 30475-30482/, 2001/08
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Identification of serum factor inducing ectodomain shedding of proHB-EGF and studies of non-cleavable mutants of proHB-EGF.
Hirata, M, Umata, T, Takahashi, T, Ohnuma, M, Miura, Y, Iwamoto R, Mekada, E
Biochem. Biophys. Res. Commun. Vol. 283 No. 4 p. 915-922 2001/08
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Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice.
Saito, M, Iwawaki, T, Taya, C, Yonekawa, H, Munehiro, N, Inui, Y, Mekada, E, Kimata, Y, Tsuru, A, Kohno, K
Nat. Biotechnol. Vol. 19 No. 8 p. 746-750 2001/08
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Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis.
Kusukawa, J, Ryu, F, Kameyama, T, Mekada, E
J. Oral Pathol. Med. Vol. 30 No. 2 p. 73-79 2001/07
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Identification of serum factor inducing ectodomain shedding of proHB-EGF and studies of noncleavable mutants of proHB-EGF
M Hirata, T Umata, T Takahashi, M Ohnuma, Y Miura, R Iwamoto, E Mekada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 283 No. 4 p. 915-922 2001/05
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Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor, and integrin alpha 3 beta 1 in normal human tissues
Y Nakamura, K Handa, R Iwamoto, T Tsukamoto, M Takahasi, E Mekada
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY Vol. 49 No. 4 p. 439-444 2001/04
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Extension of juxtamembrane domain of diphtheria toxin receptor arrests translocation of diphtheria toxin fragment A into cytosol.
Takahashi, T, Umata, T, Mekada, E
Biochem. Biophys. Res. Commun. Vol. 281 No. 3 p. 690-696 2001/04
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Extension of juxtamembrane domain of diphtheria toxin receptor arrests translocation of diphtheria toxin fragment A into cytosol
T Takahashi, T Umata, E Mekada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 281 No. 3 p. 690-696 2001/03
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Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis
J Kusukawa, F Ryu, T Kameyama, E Mekada
JOURNAL OF ORAL PATHOLOGY & MEDICINE Vol. 30 No. 2 p. 73-79 2001/02
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A dual signaling cascade that regulates the ectodomain shedding of HB-EGF.(共著)
J. Biol. Chem. Vol. 276, 30475-30482/, 2001
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Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells
Baba, I, S Shirasawa, R Iwamoto, K Okumura, T Tsunoda, M Nishioka, K Fukuyama, K Yamamoto, E Mekada, T Sasazuki
CANCER RESEARCH Vol. 60 No. 24 p. 6886-6889 2000/12
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Domain analysis of the tetraspanins: Studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding
F Ryu, T Takahashi, K Nakamura, Y Takahashi, T Kobayashi, S Shida, T Kameyama, E Mekada
CELL STRUCTURE AND FUNCTION Vol. 25 No. 5 p. 317-327 2000/10
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Domain analysis of the tetraspanins: Studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding
F Ryu, T Takahashi, K Nakamura, Y Takahashi, T Kobayashi, S Shida, T Kameyama, E Mekada
CELL STRUCTURE AND FUNCTION Vol. 25 No. 5 p. 317-327 2000/10
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ヒトTom22のクローニングと機能解析
佐伯 和子, 鈴木 寛之, 常岡 誠, 前田 真希, 阪口 雅郎, 遠藤 斗志也, 三浦 芳樹, 目加田 英輔, 三原 勝芳
生化学 Vol. 72 No. 8 p. 812-812 2000/08/25
Publisher: (公社)日本生化学会
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Heparin-binding EGF-like growth factor : a juxtacrine growth factor.
MEKADA Eisuke
Cytokine & Growth Factor Reviews Vol. 11 No. 4 p. 335-344 2000/04 Book review, literature introduction, etc.
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Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor and integrin a3bl in normal human tissues.
MEKADA Eisuke
J. Histochem. Cytochem. Vol. 49 No. 4 p. 439-444 2000/04
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Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cencer cells.
MEKADA Eisuke
Cancer Res. Vol. 60 No. 24 p. 6886-6889 2000/04
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A crucial role of tetraspanin, CD9 in fertilization
K. Miyado, E. Mekada, K. Kobayashi
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol. 45 No. 10 p. 1728-1734 2000 Book review, literature introduction, etc.
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Signal transducion of epidermal growth factro (EGF) is accelerated by pre-clustering of EGF receptor
Sako Y., Yu X., Mekada E., Yanagida T.
Seibutsu Butsuri Vol. 40 No. 0 2000
Publisher: The Biophysical Society of Japan General Incorporated Association
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Expression or heparin-binding epidermal growth factor-like growth factor in hepatocellular carcinoma and noncancerous tissues.
K Higaki, H Yano, M Haramaki, Y Shishido, S Ogasawa, J Akiba, E Mekada, M Kojiro
HEPATOLOGY Vol. 30 No. 4 p. 260A-260A 1999/10 Research paper, summary (international conference)
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CD9 reduces xenotransplantability of human hepatoma cells into nude mice.
M Haramaki, H Yano, Y Shishido, K Higaki, E Mekada, M Kojiro
HEPATOLOGY Vol. 28 No. 4 p. 513A-513A 1998/10 Research paper, summary (international conference)
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Institute of Life Science, Kurume University
MEKADA E.
Vol. 68 No. 9 p. 1572-1573 1996/09/25
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膜4回貫通型タンパク質 CD9 とそのファミリー
目加田 英輔
生化学 Vol. 67 No. 3 p. 224-228 1995/03/25
Publisher: 日本生化学会
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PARTIAL-PURIFICATION OF DIPHTHERIA-TOXIN RECEPTOR
E MEKADA, H SENOH, Y OKADA, T UCHIDA
CELL STRUCTURE AND FUNCTION Vol. 12 No. 6 p. 676-676 1987/12 Research paper, summary (international conference)
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PARTIAL-PURIFICATION OF DIPHTHERIA-TOXIN RECEPTOR
E MEKADA, H SENOH, Y OKADA, T UCHIDA
CELL STRUCTURE AND FUNCTION Vol. 11 No. 4 p. 488-488 1986/12 Research paper, summary (international conference)
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CHARACTERIZATION AND APPLICATION OF MONOCLONAL-ANTIBODIES AGAINST DIPHTHERIA-TOXIN FRAGMENT-A
T YOSHIMORI, M YAMADA, H SUGAWA, E MEKADA, T UCHIDA, Y OKADA
JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY Vol. 37 No. 4 p. 199-199 1984 Research paper, summary (international conference)
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MONOCLONAL-ANTIBODIES AGAINST DIPHTHERIA-TOXIN AND ANALYSIS OF DIPHTHERIA-TOXIN USING THEM
S HAYAKAWA, T UCHIDA, E MEKADA, K TAKAMATSU, Y OKADA
CELL STRUCTURE AND FUNCTION Vol. 6 No. 4 p. 434-434 1981 Research paper, summary (international conference)
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TRANSDIFFERENTIATION OF NEURONAL CELLS SEPARATED BY CELL SORTER
K NOMURA, E MEKADA, S TAKAGI, TS OKADA
DEVELOPMENT GROWTH & DIFFERENTIATION Vol. 23 No. 4 p. 449-449 1981 Research paper, summary (international conference)
