Impact of Remnant Lipoprotein on Coronary Plaque Components

Natsumi Matsuo, Tetsuro Matsuoka, Sumire Onishi, Hiroyasu Yamamoto, Akinobu Kato, Yasunaka Makino, Shinji Kihara

J Atheroscler Thromb　2015/08　Research paper (scientific journal)

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

Lo Sasso G, Menzies KJ, Mottis A, Piersigilli A, Perino A, Yamamoto H, Schoonjans K, Auwerx J

PLos One　Vol. 9　No. 7　2014/07　Research paper (scientific journal)

Autoimmune severe hypertriglyceridemia induced by anti-apolipoprotein C-II antibody

Hiroyasu Yamamoto, Minoru Tanaka, Satomi Yoshiga, Tohru Funahashi, Iichiro Shimomura, Shinji Kihara

Journal of Clinical Endocrinology and Metabolism　Vol. 99　No. 5　p. 1525-1530　2014　Research paper (scientific journal)

Novel combined GPIHBP1 mutations in a patient with hypertriglyceridemia associated with CAD

Hiroyasu Yamamoto, Misa Onishi, Naoko Miyamoto, Ryosuke Oki, Hiroyasu Ueda, Masato Ishigami, Hisatoyo Hiraoka, Yuji Matsuzawa, Shinji Kihara

Journal of Atherosclerosis and Thrombosis　Vol. 20　No. 10　p. 777-784　2013　Research paper (scientific journal)

LRH-1-dependent glucose sensing determines intermediary metabolism in liver.

Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K

Journal of Clinical Investigation　Vol. 122　No. 8　p. 2817-2826　2012/08　Research paper (scientific journal)

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J

Cell Metabolism　Vol. 15　No. 6　p. 838-847　2012/06　Research paper (scientific journal)

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.

Fernandez-Marcos PJ, Jeninga EH, Canto C, Harach T, de Boer VC, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten SM, Schoonjans K, Auwerx J

Sci Rep　Vol. 2　2012/05　Research paper (scientific journal)

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.

Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J

Cell　Vol. 147　No. 4　p. 827-839　2011/11　Research paper (scientific journal)

Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity.

Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM

Cell　Vol. 147　No. 4　p. 815-826　2011/11　Research paper (scientific journal)

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.

Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J

Proc Natl Acad Sci U S A.　Vol. 108　No. 43　p. E952-E961　2011/10　Research paper (scientific journal)

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

NORIEGA LG

EMBO Rep　Vol. 12　No. 10　p. 1069-1076　2011/09　Research paper (scientific journal)

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J

Cell Metabolism　Vol. 13　No. 4　p. 461-468　2011/04　Research paper (scientific journal)

PARP-2 regulates SIRT1 expression and whole-body energy expenditure.

Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J

Cell Metabolism　Vol. 13　No. 4　p. 450-460　2011/04　Research paper (scientific journal)

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

RUTANEN J

Diabetes　Vol. 59　No. 4　p. 829-835　2010/04　Research paper (scientific journal)

Effects of Pitavastatin on Serum Lipids and High Sensitivity C-Reactive Protein in Type 2 Diabetic Patients

MOTOMURA Takashi, OKAMOTO Maki, KITAMURA Tetsuhiro, YAMAMOTO Hiroyasu, OTSUKI Michio, ASANUMA Nobuyuki, TAKAGI Miki, KUREBAYASHI Shogo, HASHIMOTO Kunihiko, SUMITANI Satoru, SAITO Hiroshi, KOUHARA Haruhiko, NISHII Kazumasa, NAKAO Makoto, KOGA Masafumi, SATO Bunzo, MORIMOTO Yasuhiko, KASAYAMA Soji

Vol. 16　No. 5　p. 546-552　2009/10　Research paper (scientific journal)

TGR5-mediated bile acid sensing controls glucose homeostasis

THOMAS C

Cell Metab　Vol. 10　No. 3　p. 167-177　2009/09　Research paper (scientific journal)

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance

CHAVEY C

Cell Metab　Vol. 9　No. 4　p. 339-349　2009/04　Research paper (scientific journal)

グリメピリド長期投与２型糖尿病患者の臨床的特徴

大月道夫, 笠山宗正, 幸原晴彦, 斉藤博, 住谷哲, 山本浩靖, 稲葉真紀子, 下村伊一郎

新薬と臨床　Vol. 58　p. 94-100　2009/01　Research paper (scientific journal)

Asthma is an independent risk for elevation of plasma C-reactive protein levels.

Kasayama S, Tanemura M, Koga M, Fujita K, Yamamoto H, Miyatake A

Clin Chim Acta　Vol. 399　No. 1-2　p. 79-82　2009/01　Research paper (scientific journal)

A novel growth hormone receptor gene deletion mutation in a patient with primary growth hormone insensitivity syndrome (Laron syndrome).

Yamamoto H, Kouhara H, Iida K, Chihara K, Kasayama S

Growth Horm IGF Res.　Vol. 18　No. 2　p. 136-142　2008/04　Research paper (scientific journal)

Sirtuin functions in health and disease.

Yamamoto H, Schoonjans K, Auwerx J

Molecular Endocrinology　Vol. 21　No. 8　p. 1745-1755　2007/08

Impacts of long-term treatments with testosterone replacement and pioglitazone on glucose and lipid metabolism in male patients with Werner's syndrome.

Yamamoto H, Kurebayashi S, Kouhara H, Yoshiuchi K, Matsuhisa M, Yamasaki Y, Kasayama S

Clin Chim Acta　Vol. 379　No. 1-2　p. 167-170　2007/04　Research paper (scientific journal)

The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells.

Goya K, Sumitani S, Otsuki M, Xu X, Yamamoto H, Kurebayashi S, Saito H, Kouhara H, Kasayama S

J Diabetes Complications.　Vol. 20　No. 5　p. 336-342　2006/09　Research paper (scientific journal)

Improvement of Reduced Bone Mineral Density by Intermittent Cyclical Etidronate in Postmenopausal Asthmatic Patients Receiving Inhaled Corticosteroids.

Yamamoto H, Kasayama S, Fujita M, Fujita K, Morimoto Y, Kawase I, Miyatake A

Allergology International　Vol. 54　p. 137-141　2005/09　Research paper (scientific journal)

Effects of alendronate on bone mineral density and bone metabolic markers in postmenopausal asthmatic women treated with inhaled corticosteroids.

Kasayama S, Fujita M, Goya K, Yamamoto H, Fujita K, Morimoto Y, Kawase I, Miyatake A

Metabolism　Vol. 54　No. 1　p. 85-90　2005/01　Research paper (scientific journal)

Strong association of C-reactive protein with body mass index and 2-h post-challenge glucose in non-diabetic, non-smoker subjects without hypertension

HASHIMOTO K

Diabet Med　Vol. 21　No. 6　p. 581-585　2004/06　Research paper (scientific journal)

Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.

Goya K, Sumitani S, Xu X, Kitamura T, Yamamoto H, Kurebayashi S, Saito H, Kouhara H, Kasayama S, Kawase I

Arterioscler Thromb Vasc Biol.　Vol. 24　No. 4　p. 658-663　2004/04　Research paper (scientific journal)

Runx2 deficiency in chondrocytes causes adipogenic changes in vitro

ENOMOTO H.

J. Cell Sci.　Vol. 117　No. 3　p. 417-425　2004/01　Research paper (scientific journal)

Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members.

Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, Kirkwood KL, Gaffen SL

Journal of Biological Chemistry　Vol. 279　No. 4　p. 2559-2567　2004/01　Research paper (scientific journal)

Risk factors for asymptomatic atherosclerosis in Japanese type 2 diabetic patients without diabetic microvascular complications.

Goya K, Kitamura T, Inaba M, Otsuki M, Yamamoto H, Kurebayashi S, Sumitani S, Saito H, Kouhara H, Kasayama S, Kawase I

Metabolism　Vol. 52　No. 10　p. 1302-1306　2003/10　Research paper (scientific journal)

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.

Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M

Journal of Biological Chemistry　Vol. 278　No. 29　p. 18440-18447　2003/05　Research paper (scientific journal)

糖尿病患者にみられる神経障害の自覚症状の特徴

山本浩靖, 大月道夫, 高木美紀, 西井一雅, 森本靖彦, 三木俊治, 佐藤文三, 笠山宗正

新薬と臨床　Vol. 52　p. 138-144　2003/01　Research paper (scientific journal)

Acromegaly患者における耐糖能障害に及ぼす手術療法と薬物療法の効果

山本浩靖, 笠山宗正

第１回関西間脳下垂体研究会記録集　Vol. 1　p. 4-5　2003/01

Reduced IRS-2 and GLUT4 expression in PPARgamma2-induced adipocytes derived from C/EBPbeta and C/EBPdelta-deficient mouse embryonic fibroblasts.

Yamamoto H, Kurebayashi S, Hirose T, Kouhara H, Kasayama S

Journal of Cell Science　Vol. 115　No. 18　p. 3601-3607　2002/09　Research paper (scientific journal)

Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals

KISHIMA Y

J Biol Chem　Vol. 277　No. 12　p. 10315-10322　2002/03　Research paper (scientific journal)

Characterization of premature atherosclerosis of carotid arteries in acromegalic patients.

Otsuki M, Kasayama S, Yamamoto H, Saito H, Sumitani S, Kouhara H, Saitoh Y, Ohnishi T, Arita N

Clinical Endocrinology　Vol. 54　No. 6　p. 791-796　2001/06　Research paper (scientific journal)

下垂体前葉機能低下症と尿崩症を合併し、術後に下垂体前葉機能のみ回復を認めた下垂体膿瘍の1例

古川貢, 山本浩靖, 幸原晴彦, 羽柴哲夫, 稲垣昌士, 大西丘倫, 笠山宗正

ホルモンと臨床　Vol. 49　p. 14-18　2001/01　Research paper (scientific journal)

PPARα and GR differentially down-regulate the expression of nuclear factor-κB-responsive genes in vascular endothelial cells

Xin Xu, Michio Otsuki, Hiroshi Saito, Satoru Sumitani, Hiroyasu Yamamoto, Nobuyuki Asanuma, Haruhiko Kouhara, Soji Kasayama

Endocrinology　Vol. 142　No. 8　p. 3332-3339　2001　Research paper (scientific journal)

ペン型インスリン注入器ヒューマペンエルゴを用いたインスリン導入が２型糖尿病患者のインスリン治療イメージに与える影響

高木美紀, 元村卓嗣, 西井一雅, 山本浩靖, 大月道夫, 住谷哲, 幸原晴彦, 笠山宗正

新薬と臨床　Vol. 49　p. 1049-1054　2000/01　Research paper (scientific journal)

脂肪細胞分化に伴うGLUT4発現におけるC/EBP-β、-δの役割－C/EBP-β、-δ欠損マウス由来繊維芽細胞を用いた解析－

山本浩靖, 紅林昌吾, 住谷哲, 弘世貴久, 住谷哲, 幸原晴彦, 笠山宗正

Diabetes Frontier　Vol. 11　2000/01

脂肪細胞の分化は、C/EBP-β、-δ 非存在下でもPPAR-γ2の強制発現にて誘導し得る

山本浩靖, 紅林昌吾, 住谷哲, 弘世貴久, 幸原晴彦, 笠山宗正, 岸本忠三

分子糖尿病学　Vol. 10　p. 41-45　1999/01　Research paper (scientific journal)

PPAR- γ2によるマウス胎児由来線維芽細胞の脂肪細胞への分化

山本浩靖, 紅林昌吾, 弘世貴久, 住谷哲, 幸原晴彦, 笠山宗正

ホルモンと臨床　Vol. 47　p. 63-67　1999/01　Research paper (scientific journal)

NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27.

Yamamoto H, Kishimoto T, Minamoto S

Journal of Immunology　Vol. 161　No. 9　p. 4753-4759　1998/11　Research paper (scientific journal)

Cloning and Functional Analysis of New Members of STAT Induced STAT Inhibitor (SSI) Family: SSI-2 and SSI-3

Seijiro Minamoto, Kazuhiro Ikegame, Kiyonobu Ueno, Masashi Narazaki, Tetsuji Naka, Hiroyasu Yamamoto, Tomoshige Matsumoto, Hiroshi Saito, Shigeto Hosoe, Tadamitsu Kishimoto

Biochemical and Biophysical Research Communications　Vol. 237　No. 1　p. 79-83　1997/08　Research paper (scientific journal)

A Patient with Acromegaly Who Showed Remarkable Improvement of Hyperglycemia after Treatment with Octreotide

HIROSE Takahisa, KURODA Tadashi, OTSUKI Michio, TAKAGI Miki, YAMAMOTO Hiroyasu, MOTOMURA Takashi, KUREBAYASHI Shogo, MIYASHITA Yoshihiro, KOGA Masafumi, ARITA Norio, HAYAKAWA Toru, KISHIMOTO Tadamitsu, KASAYAMA Soji

Japanese Journal of Medicine　Vol. 36　No. 5　p. 345-350　1997/05　Research paper (scientific journal)

Advanced glycation end products stimulate interleukin-6 production by human bone-derived cells

TAKAGI M

J Bone Miner Res　Vol. 12　No. 3　p. 439-446　1997/03　Research paper (scientific journal)

原発性無月経を呈した46X, pseu dic (X)(pter→q25: q25→pter) の１症例

山本浩靖, 幸原晴彦, 中尾皖英, 橋本久仁彦, 宮下義博, 笠山宗正, 古賀正史, 佐藤文三, 岸本忠三

ホルモンと臨床　Vol. 43　p. 272-275　1995/01　Research paper (scientific journal)