Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells

Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai

Journal of Pharmacological Sciences　Vol. 155　No. 1　p. 14-20　2024/05　Research paper (scientific journal)

The LAT1 inhibitor JPH203 suppresses the growth of castration-resistant prostate cancer through a CD24-mediated mechanism.

Shinpei Saito, Keisuke Ando, Shinichi Sakamoto, Minhui Xu, Yasutaka Yamada, Junryo Rii, Sanji Kanaoka, Jiaxing Wei, Xue Zhao, Sangjon Pae, Manato Kanesaka, Yusuke Goto, Tomokazu Sazuka, Yusuke Imamura, Yoshie Reien, Norie Hamaguchi-Suzuki, Shota Saito, Yuri Hirayama, Hirofumi Hashimoto, Yoshikatsu Kanai, Tomohiko Ichikawa, Naohiko Anzai

Cancer science　2024/04/24　Research paper (scientific journal)

Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation

Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai

Journal of Pharmacological Sciences　Vol. 154　No. 3　p. 182-191　2024/03　Research paper (scientific journal)

Structure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)

Sihui Chen, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai

Scientific Reports　Vol. 14　No. 1　2024/02/26　Research paper (scientific journal)

Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells

Xingming Liu, Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Yoshikatsu Kanai

Journal of Pharmacological Sciences　2024/02　Research paper (scientific journal)

L-type amino acid transporter 1 inhibitor JPH203 prevents the growth of cabazitaxel-resistant prostate cancer by inhibiting cyclin-dependent kinase activity.

Junryo Rii, Shinichi Sakamoto, Atsushi Mizokami, Minhui Xu, Ayumi Fujimoto, Shinpei Saito, Hidekazu Koike, Takaaki Tamura, Takayuki Arai, Yasutaka Yamada, Yusuke Goto, Tomokazu Sazuka, Yusuke Imamura, Kazuhiro Suzuki, Yoshikatsu Kanai, Naohiko Anzai, Tomohiko Ichikawa

Cancer science　2024/01/07　Research paper (scientific journal)

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.

Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Satoru Kawamura, Eri Wakai, Tsuyoshi Miyoshi, Takashi Sato, Yumi Ohta, Takashi Saito, Takaomi C Saido, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino

PloS one　Vol. 19　No. 5　2024　Research paper (scientific journal)

The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function.

Weidong Zhang, Ayako Miura, Md Moin Abu Saleh, Koichiro Shimizu, Yuichiro Mita, Ryota Tanida, Satoshi Hirako, Seiji Shioda, Valery Gmyr, Julie Kerr-Conte, Francois Pattou, Chunhuan Jin, Yoshikatsu Kanai, Kazuki Sasaki, Naoto Minamino, Hideyuki Sakoda, Masamitsu Nakazato

Nature communications　Vol. 14　No. 1　p. 8158-8158　2023/12/09　Research paper (scientific journal)

Evaluation of LAT1 Expression in Patients With Lung Cancer and Mediastinal Tumors: 18F-FBPA PET Study With Immunohistological Comparison.

Tadashi Watabe, Naoko Ose, Sadahiro Naka, Eriko Fukui, Toru Kimura, Takashi Kanou, Soichiro Funaki, Hidetaka Sasaki, Takashi Kamiya, Kenta Kurimoto, Kayako Isohashi, Mitsuaki Tatsumi, Eku Shimosegawa, Hiroki Kato, Ryuichi Ohgaki, Yoshikatsu Kanai, Yasushi Shintani

Clinical nuclear medicine　Vol. 48　No. 10　p. 853-860　2023/10/01　Research paper (scientific journal)

The Clinical Potential of FBPA-PET/CT Imaging for Colorectal Cancer and its Liver Metastases Expressing LAT1.

Takayuki Minoji, Hidekazu Takahashi, Tadashi Watabe, Satoshi Ishikawa, Hiroki Kato, Ryuichi Ohgaki, Yoshikatsu Kanai, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi

Anticancer research　Vol. 43　No. 9　p. 3913-3921　2023/09　Research paper (scientific journal)

Inhibition of Cancer-type Amino Acid Transporter LAT1 Suppresses B16-f10 Melanoma Metastasis in Mouse Models.

Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai

Scientific Reports　Vol. 13　No. 1　p. 13943-13943　2023/08/25　Research paper (scientific journal)

Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells

Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Cancer Cell International　Vol. 23　No. 1　2023/06/15　Research paper (scientific journal)

アミノ酸トランスポーターLAT1はカバジタキセル耐性前立腺癌細胞においてCDK1とCDK2を介して細胞増殖に寄与する(LAT1 plays a critical role in cell proliferation via CDK1 and CDK2 in cabazitaxel-resistant prostate cancer cells)

梨井 隼菱, 坂本 信一, 溝上 敦, 斎藤 心平, 田村 貴明, 新井 隆之, 佐塚 智和, 今村 有佑, 安西 尚彦, 金井 好克, 市川 智彦

日本泌尿器科学会総会　Vol. 110回　p. PP61-08　2023/04

アミノ酸トランスポーターLAT1はカバジタキセル耐性前立腺癌細胞においてCDK1とCDK2を介して細胞増殖に寄与する(LAT1 plays a critical role in cell proliferation via CDK1 and CDK2 in cabazitaxel-resistant prostate cancer cells)

梨井 隼菱, 坂本 信一, 溝上 敦, 斎藤 心平, 田村 貴明, 新井 隆之, 佐塚 智和, 今村 有佑, 安西 尚彦, 金井 好克, 市川 智彦

日本泌尿器科学会総会　Vol. 110回　p. PP61-08　2023/04

LAT1 expression influences Paneth cell number and tumor development in ApcMin/+ mice

Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama

Journal of Gastroenterology　2023/02/05　Research paper (scientific journal)

Targeting L-type amino acid transporter 1 in urological malignancy: Current status and future perspective.

Sangjon Pae, Shinichi Sakamoto, Xue Zhao, Shinpei Saito, Takaaki Tamura, Yusuke Imamura, Tomokazu Sazuka, Yoshie Reien, Yuri Hirayama, Hirofumi Hashimoto, Yoshikatsu Kanai, Tomohiko Ichikawa, Naohiko Anzai

Journal of pharmacological sciences　Vol. 150　No. 4　p. 251-258　2022/12　Research paper (scientific journal)

Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

Hiroki Okanishi, Ryuichi Ohgaki, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Cancer & Metabolism　Vol. 10　No. 1　2022/11/10　Research paper (scientific journal)

Tmem174はリン酸トランスポーターを調節し高リン血症を予防する

佐々木 すみれ, 塩崎 雄治, 小池 萌, 谷藤 和也, 宇賀 穂, Wiriyasermkul Pattama, 長谷川 智香, 網塚 憲生, 宮本 賢一, 永森 收志, 金井 好克, 瀬川 博子

日本生化学会大会プログラム・講演要旨集　Vol. 95回　p. 1T08a-08　2022/11

Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8.

Maya Nakatani, Shun-Ya Nakahara, Kenji Fukui, Momoka Urano, Yuki Fujii, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Hiroki Okanishi, Yoshikatsu Kanai, Takato Yano, Ryoji Masui

J Struct Biol　Vol. 214　No. 4　p. 107904-107904　2022/10/11　Research paper (scientific journal)

Pharmacologic inhibition of <scp>LAT1</scp> predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells

Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Journal of Cellular and Molecular Medicine　2022/09/07　Research paper (scientific journal)

去勢抵抗性前立腺癌におけるアミノ酸トランスポーターLAT1選択的阻害薬JPH203の効果(L-type amino acid transporter 1 inhibitor JPH203 as a new therapeutic target for castration resistant prostate cancer)

坂本 信一, 齋藤 心平, 安藤 敬介, 梨井 隼菱, 徐 旻恵, 金井 好克, 安西 尚彦, 市川 智彦

日本癌学会総会記事　Vol. 81回　p. E-3078　2022/09

低侵襲治療を目指した短寿命アルファ線核医学治療薬の開発(Development of short-lived alpha-emitting nuclear medicine aiming at minimally invasive cancer treatment)

兼田 加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 篠原 厚, 深瀬 浩一

日本癌学会総会記事　Vol. 81回　p. J-1008　2022/09

低侵襲治療を目指した短寿命アルファ線核医学治療薬の開発(Development of short-lived alpha-emitting nuclear medicine aiming at minimally invasive cancer treatment)

兼田 加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 篠原 厚, 深瀬 浩一

日本癌学会総会記事　Vol. 81回　p. J-1008　2022/09

Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10

Naoko Ohtsu, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Ryo Takahashi, Akiko Matsui, Wataru Kishimoto, Naoki Ishiguro, Yoshikatsu Kanai

Journal of Pharmacological Sciences　Vol. 150　No. 1　p. 41-48　2022/09　Research paper (scientific journal)

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki

Nature Communications　Vol. 13　No. 1　2022/08/11　Research paper (scientific journal)

Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia

Sumire Sasaki, Yuji Shiozaki, Ai Hanazaki, Megumi Koike, Kazuya Tanifuji, Minori Uga, Kota Kawahara, Ichiro Kaneko, Yasuharu Kawamoto, Pattama Wiriyasermkul, Tomoka Hasegawa, Norio Amizuka, Ken-ichi Miyamoto, Shushi Nagamori, Yoshikatsu Kanai, Hiroko Segawa

Scientific Reports　Vol. 12　No. 1　p. 6353-6353　2022/05　Research paper (scientific journal)

Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer.

Sasagu Kurozumi, Kyoichi Kaira, Hiroshi Matsumoto, Masafumi Kurosumi, Takehiko Yokobori, Yoshikatsu Kanai, Chikako Sekine, Chikako Honda, Ayaka Katayama, Mio Furuya, Sho Shiino, Takaya Makiguchi, Nigel P Mongan, Emad A Rakha, Tetsunari Oyama, Takaaki Fujii, Ken Shirabe, Jun Horiguchi

Scientific reports　Vol. 12　No. 1　p. 2742-2742　2022/02/17　Research paper (scientific journal)

Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain

Kana Hasegawa, Shunya Ikeda, Moto Yaga, Kouki Watanabe, Rika Urakawa, Akie Iehara, Mai Iwai, Seishin Hashiguchi, Soyoko Morimoto, Fumihiro Fujiki, Hiroko Nakajima, Jun Nakata, Sumiyuki Nishida, Akihiro Tsuboi, Yoshihiro Oka, Satoshi Yoshihara, Masahiro Manabe, Hiroyoshi Ichihara, Atsuko Mugitani, Yasutaka Aoyama, Takafumi Nakao, Asao Hirose, Masayuki Hino, Shiho Ueda, Katsuto Takenaka, Takashi Masuko, Koichi Akashi, Takahiro Maruno, Susumu Uchiyama, Shinji Takamatsu, Naoki Wada, Eiichi Morii, Shushi Nagamori, Daisuke Motooka, Yoshikatsu Kanai, Yusuke Oji, Tomoyoshi Nakagawa, Noriyuki Kijima, Haruhiko Kishima, Atsuyo Ikeda, Takayuki Ogino, Yasushi Shintani, Tateki Kubo, Emiko Mihara, Kosuke Yusa, Haruo Sugiyama, Junichi Takagi, Eiji Miyoshi, Atsushi Kumanogoh, Naoki Hosen

Science Translational Medicine　Vol. 14　No. 632　2022/02/16　Research paper (scientific journal)

Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics

Yoshikatsu Kanai

Pharmacology & Therapeutics　Vol. 230　p. 107964-107964　2022/02　Research paper (scientific journal)

Contribution of LAT1 to amino acid uptake in cancer cells and suppression of cellular protein synthesis by LAT1 inhibitor

Nishikubo Kou, Ohgaki Ryuichi, Okanishi Hiroki, Okuda Suguru, Xu Minhui, Endou Hitoshi, Kanai Yoshikatsu

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022　Research paper (other academic)

Simple but efficacious enrichment of integral membrane proteins and their interactions for in-depth membrane proteomics

Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Satomi Moriyama, Yoshikatsu Kanai, Shushi Nagamori

Molecular & Cellular Proteomics　p. 100206-100206　2022/01　Research paper (scientific journal)

The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2

Maihulan Maimaiti, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka, Ayumi Fujimoto, Keisuke Matsusaka, Minhui Xu, Keisuke Ando, Shinpei Saito, Ken Wakai, Yusuke Imamura, Keiichi Nakayama, Yoshikatsu Kanai, Atsushi Kaneda, Yuzuru Ikehara, Jun-Ichiro Ikeda, Naohiko Anzai, Tomohiko Ichikawa

Scientific Reports　Vol. 11　No. 1　2021/12　Research paper (scientific journal)

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp

Weijun Liu, Ling Wei, Yoshikatsu Kanai, Xin He

Evidence-Based Complementary and Alternative Medicine　Vol. 2021　p. 1-11　2021/10/05　Research paper (scientific journal)

[18F]FBPA新規合成法における加水分解条件の検討

金井 泰和, 渡辺 利光, 大田 洋一郎, 井口 佳哉, 堺 俊博, 仲 定宏, 服部 能英, 上原 幸樹, 片岡 昌治, 金井 好克, 切畑 光統

核医学　Vol. 58　No. Suppl.　p. S232-S232　2021/10

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters

Stephen PH Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Laura Amarosi, Catriona M. H. Anderson, Philip Mark Beart, Stefan Broer, Paul A. Dawson, Bruno Hagenbuch, James R. Hammond, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Gavin Stewart, David T. Thwaites, Tiziano Verri

British Journal of Pharmacology　Vol. 178　No. S1　2021/10　Research paper (scientific journal)

万能治療を目指した短寿命アルファ線核医学治療薬の開発

兼田 加珠子, 真鍋 良幸, 下山 敦史, 樺山 一哉, 金井 好克, 豊嶋 厚史, 深瀬 浩一, 篠原 厚

日本癌学会総会記事　Vol. 80回　p. [J19-3]　2021/09　Research paper (other academic)

Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor

Junryo Rii, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka, Ayumu Fujimoto, Yasutaka Yamada, Maihulan Maimaiti, Keisuke Ando, Ken Wakai, Minhui Xu, Yusuke Imamura, Norihisa Shindo, Toru Hirota, Atsushi Kaneda, Yoshikatsu Kanai, Yuzuru Ikehara, Naohiko Anzai, Tomohiko Ichikawa

Cancer Science　2021/07/08　Research paper (scientific journal)

Amino acid transporter LAT1 is upregulated in tumor-associated vascular endothelial cells and plays essential roles in tumor angiogenesis by promoting proliferation and regulating VEGF-A-dependent pro-angiogenic mTORC1 activation.

Ohgaki Ryuichi, Quan Lili, Okuda Suguru, Okanishi Hiroki, Nagamori Shushi, Endou Hitoshi, Kanai Yoshikatsu

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Expression of LAT1 and 4F2hc in Gastroenteropancreatic Neuroendocrine Neoplasms

YOSUKE HORITA, KYOICHI KAIRA, TOMONORI KAWASAKI, YOSHIAKI MIHARA, SHINICHI SAKURAMOTO, SHIGEKI YAMAGUCHI, KOJUN OKAMOTO, SHOMEI RYOZAWA, YOSHIKATSU KANAI, MASANORI YASUDA, TETSUYA HAMAGUCHI

In Vivo　Vol. 35　No. 4　p. 2425-2432　2021　Research paper (scientific journal)

Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.

Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo

PloS one　Vol. 16　No. 2　2021

Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer

Masahiro Sugiura, Hiroaki Sato, Atsushi Okabe, Masaki Fukuyo, Yasunobu Mano, Ken-ichi Shinohara, Bahityar Rahmutulla, Kosuke Higuchi, Maihulan Maimaiti, Manato Kanesaka, Yusuke Imamura, Tomomi Furihata, Shinichi Sakamoto, Akira Komiya, Naohiko Anzai, Yoshikatsu Kanai, Jun Luo, Tomohiko Ichikawa, Atsushi Kaneda

Translational Oncology　Vol. 14　No. 1　p. 100915-100915　2021/01　Research paper (scientific journal)

Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model

Tatsuhiko Sato, Takuya Furuta, Yuwei Liu, Sadahiro Naka, Shushi Nagamori, Yoshikatsu Kanai, Tadashi Watabe

EJNMMI Physics　Vol. 8　No. 1　p. 4-4　2021/01　Research paper (scientific journal)

α‐Emitting cancer therapy using 211 At‐AAMT targeting LAT1

Kazuko Kaneda‐Nakashima, ZiJian Zhang, Yoshiyuki Manabe, Atsushi Shimoyama, Kazuya Kabayama, Tadashi Watabe, Yoshikatsu Kanai, Kazuhiro Ooe, Atsushi Toyoshima, Yoshifumi Shirakami, Takashi Yoshimura, Mitsuhiro Fukuda, Jun Hatazawa, Takashi Nakano, Koichi Fukase, Atsushi Shinohara

Cancer Science　2020/12/05　Research paper (scientific journal)

Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor

Hiroki Okanishi, Ryuichi Ohgaki, Suguru Okuda, Hitoshi Endou, Yoshikatsu Kanai

Cancer Science　2020/12/02　Research paper (scientific journal)

Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes

Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Minhui Xu, Suguru Okuda, Hiroki Okanishi, Yasuharu Kawamoto, Xin He, Shushi Nagamori, Yoshikatsu Kanai

Journal of Pharmacology and Experimental Therapeutics　Vol. 375　No. 3　p. 451-462　2020/12　Research paper (scientific journal)

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai

Journal of Experimental & Clinical Cancer Research　Vol. 39　No. 1　2020/12　Research paper (scientific journal)

Structural changes induced by ligand binding drastically increase the thermostability of the Ser/Thr protein kinase TpkD from Thermus thermophilus HB8

Yusuke Fujino, Takero Miyagawa, Masayuki Torii, Masao Inoue, Yuki Fujii, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui

FEBS Letters　2020/11/28　Research paper (scientific journal)

A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy

Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo

PLOS ONE　Vol. 15　No. 11　p. e0241869-e0241869　2020/11/09　Research paper (scientific journal)

Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application

Gergely Gyimesi, Jonai Pujol-Giménez, Yoshikatsu Kanai, Matthias A. Hediger

Pflügers Archiv - European Journal of Physiology　Vol. 472　No. 9　p. 1177-1206　2020/09　Research paper (scientific journal)

Targeted alpha therapy using astatine (211At)-labeled phenylalanine: A preclinical study in glioma bearing mice.

Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuwei Liu, Kazuhiro Ooe, Takahiro Teramoto, Atsushi Toyoshima, Eku Shimosegawa, Takashi Nakano, Yoshikatsu Kanai, Atsushi Shinohara, Jun Hatazawa

Oncotarget　Vol. 11　No. 15　p. 1388-1398　2020/04/14　Research paper (scientific journal)

Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma.

Maihulan Maimaiti, Shinichi Sakamoto, Yasutaka Yamada, Masahiro Sugiura, Junryo Rii, Nobuyoshi Takeuchi, Yusuke Imamura, Tomomi Furihata, Keisuke Ando, Kosuke Higuchi, Minhui Xu, Tomokazu Sazuka, Kazuyoshi Nakamura, Atsushi Kaneda, Yoshikatsu Kanai, Natasha Kyprianou, Yuzuru Ikehara, Naohiko Anzai, Tomohiko Ichikawa

Scientific reports　Vol. 10　No. 1　p. 1292-1292　2020/01/28　Research paper (scientific journal)

Suppression of LAT1 in endothelial cells of tumor tissues exhibits an anti-angiogenesis effect

Quan Lili, Ohgaki Ryuichi, Okuda Suguru, Nagamori Shushi, Kanai Yoshikatsu

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Evaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation.

Nobuto Hirai, Tadashi Watabe, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Victor Romanov, Sadahiro Naka, Yasukazu Kanai, Yuwei Liu, Naoki Tani, Tatsuya Sakai, Mitsuaki Tatsumi, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa

Asia Oceania journal of nuclear medicine & biology　Vol. 8　No. 2　p. 102-108　2020　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters.

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA, CGTP Collaborators

Br J Pharmacol.　Vol. 176　No. Suppl 1　p. S397-S493　2019/12

LAT1-specific inhibitor is effective against T cell-mediated allergic skin inflammation.

Hayashi K, Kaminuma O, Nishimura T, Saeki M, Matsuoka K, Hiroi T, Jutabha P, Iwata Y, Sugiura K, Owada T, Kurasawa K, Okayasu I, Ouchi M, Fujita T, Kanai Y, Endou H, Anzai N

Allergy　2019/08

Cell surface pH imaging using poly(ethylene glycol)-phospholipid: its potential as the core structure of membrane anchored-probes

大垣隆一, 寺村裕治, 林大智, 永森收志, 永森收志, 高井まどか, 金井好克

日本薬理学雑誌　Vol. 153　No. 6　p. 254-260　2019/06

CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii.

Jin C, Wu Z, Wang L, Kanai Y, He

Molecules　Vol. 24　No. 11　p. pii: E2162-2162　2019/06　Research paper (scientific journal)

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.

Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O

Nat Struct Mol Biol.　Vol. 26　No. 6　p. 510-517　2019/06　Research paper (scientific journal)

Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2.

Masanao Aoki, Tadashi Watabe, Shushi Nagamori, Sadahiro Naka, Hayato Ikeda, Pornparn Kongpracha, Genki Horitsugi, Yasukazu Kanai, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa

Annals of nuclear medicine　Vol. 33　No. 6　p. 394-403　2019/06　Research paper (scientific journal)

男性ホルモンによる腎成熟制御機構の多層的オミックス解析

佐藤 有紀, 北井 悠一郎, 内野 詠一郎, 小口 綾貴子, 永森 收志, 金井 好克, 曽我 朋義, 村川 泰裕, 柳田 素子

日本腎臓学会誌　Vol. 61　No. 3　p. 322-322　2019/05

Role of Amino Acid Transporter Expression as a Prognostic Marker in Patients With Surgically Resected Colorectal Cancer.

Ogawa H, Kaira K, Motegi Y, Yokobori T, Takada T, Katoh R, Osone K, Takahashi R, Katayama C, Oyama T, Kanai Y, Yao T, Asao T, Kuwano H, Shirabe K

Anticancer Res.　Vol. 39　No. 5　p. 2535-2543　2019/05　Research paper (scientific journal)

内リンパ液の維持に関与するらせん靱帯膜タンパク質の網羅的解析

野々村 頼子, 任 書晃, 上塚 学, 猪原 秀典, 堀井 新, 高橋 姿, 永森 收志, 金井 好克, 日比野 浩

日本耳鼻咽喉科学会会報　Vol. 122　No. 4　p. 578-578　2019/04

肥満脂肪組織におけるコリントランスポーター発現とコリン代謝動態の変化

藤島 裕也, 川知 祐介, 長尾 博文, 西澤 均, 中山 康宗, 馬場 健史, 永森 収志, 金井 好克, 喜多 俊文, 前田 法一, 福崎 英一郎, 下村 伊一郎

日本内分泌学会雑誌　Vol. 95　No. 1　p. 398-398　2019/04

アミノ酸トランスポーターLAT1の膀胱がんにおける役割とLAT1阻害剤の抗腫瘍効果に関する検討

坂本 信一, めいふーらん・めいめいてぃ, 安藤 敬佑, 竹下 暢重, 樋口 耕介, 山田 康隆, 今村 有佑, 金井 好克, 安西 尚彦, 小宮 顕, 市川 智彦

日本泌尿器科学会総会　Vol. 107回　p. OP-211　2019/04

An L-type Amino Acid Transporter-1 Specific Imaging Agent: Structure-function Relationships of Radioiodinated Tyrosine Derivatives.

Shikano N, Kanai Y, Kawai K, Inatomi J, Kim D.K, Endou H

ASVPI　Vol. 24　p. 23-28　2019/03　Research paper (bulletin of university, research institution)

Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.

Miyabe J, Ohgaki R, Saito K, Wei L, Quan L, Jin C, Liu X, Okuda S, Nagamori S, Ohki H, Yoshino K, Inohara H, Kanai Y

J Pharmacol Sci.　Vol. 139　No. 3　p. 215-222　2019/03　Research paper (scientific journal)

Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma.

Kaira K, Kawashima O, Endoh H, Imaizumi K, Goto Y, Kamiyoshihara M, Sugano M, Yamamoto R, Osaki T, Tanaka S, Fujita A, Imai H, Kogure Y, Seki Y, Shimizu K, Mogi A, Shitara Y, Oyama T, Kanai Y, Asao T

Human pathology　Vol. 84　p. 142-149　2019/02　Research paper (scientific journal)

Suppression of tumor angiogenesis by inhibition of LAT1 in stromal endothelial cells

Quan Lili, Ohgaki Ryuichi, Okuda Suguru, Nagamori Shushi, Endou Hitoshi, Kanai Yoshikatsu

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

A specific PET tracer for L-type amino acid transporter 1 (LAT1) differentiates the function of transporter in tumors from that in inflammatory lesions

Wiriyasermkul Pattama, Watabe Tadashi, Kongpracha Pornparn, Tanaka Yoko, Moriyama Satomi, Naka Sadahiro, Hatazawa Jun, Kanai Yoshikatsu, Nagamori Shushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Anti-tumor effects of L-type amino acid transporter 1 (LAT1) inhibitor in a syngeneic and orthotropic mouse model for melanoma

Shi Zitong, Ohgaki Ryuichi, Kaneda Kazuko, Okuda Suguru, Nagamori Shushi, Endou Hitoshi, Kanai Yoshikatsu

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　p. 1-SS-49　2019

Investigation of novel drug for nuclear medicine targeting to cancer specific amino acid transporter, LAT1

Kaneda Kazuko, Zhang ZiJian, Manabe Yoshiyuki, Shimoyama Atsushi, Kabayama Kazuya, Kanai Yoshikatsu, Fukase Koichi, Shinohara Atsushi

CANCER SCIENCE　Vol. 109　p. 606-606　2018/12

肥満脂肪組織におけるコリン代謝の変化

川知 祐介, 長尾 博文, 藤島 裕也, 西澤 均, 中山 康宗, 馬場 健史, 永森 收志, 金井 好克, 喜多 俊文, 福田 士郎, 前田 法一, 福崎 英一郎, 下村 伊一郎

肥満研究　Vol. 24　No. Suppl.　p. 224-224　2018/09

Amino acid transporters revisited: New views in health and disease.

Kandasamy P, Gyimesi G, Kanai Y, Hediger MA

Trends Biochem Sci.　2018/08　Research paper (scientific journal)

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.

Liang Weng, Yi-Peng Han, Atsushi Enomoto, Yasuyuki Kitaura, Shushi Nagamori, Yoshikatsu Kanai, Naoya Asai, Jian An, Maki Takagishi, Masato Asai, Shinji Mii, Takashi Masuko, Yoshiharu Shimomura, Masahide Takahashi

PLoS biology　Vol. 16　No. 3　2018/03　Research paper (scientific journal)

Relationship between LAT1 expression and resistance to chemotherapy in pancreatic ductal adenocarcinoma

Bolag Altan, Kyoichi Kaira, Akira Watanabe, Norio Kubo, Pinjie Bao, Gantumur Dolgormaa, Erkhem-Ochir Bilguun, Kenichiro Araki, Yoshikatsu Kanai, Takehiko Yokobori, Tetsunari Oyama, Masahiko Nishiyama, Hiroyuki Kuwano, Ken Shirabe

Cancer Chemotherapy and Pharmacology　Vol. 81　No. 1　p. 141-153　2018/01/01　Research paper (scientific journal)

Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease

Yasuyuki Shinozaki, Kengo Furuichi, Tadashi Toyama, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Shuichi Kaneko, Noriyoshi Isozumi, Shushi Nagamori, Yoshikatsu Kanai, Tomoko Sugiura, Yukio Kato, Takashi Wada

KIDNEY INTERNATIONAL　Vol. 92　No. 6　p. 1356-1369　2017/12　Research paper (scientific journal)

Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate

Ryuichi Ohgaki, Yuji Teramura, Daichi Hayashi, Lili Quan, Suguru Okuda, Shushi Nagamori, Madoka Takai, Yoshikatsu Kanai

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Stephen P. H. Alexander, Eamonn Kelly, Neil V. Marrion, John A. Peters, Elena Faccenda, Simon D. Harding, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, O. Peter Buneman, John A. Cidlowski, Arthur Christopoulos, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jorg Striessnig, Jamie A. Davies

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 174　No. Suppl 1　p. S1-S16　2017/12　Research paper (scientific journal)

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda

CELL REPORTS　Vol. 21　No. 7　p. 1824-1838　2017/11　Research paper (scientific journal)

JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

Dae Woo Choi, Do Kyung Kim, Yoshikatsu Kanai, Michael F. Wempe, Hitoshi Endou, Jong-Keun Kim

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY　Vol. 21　No. 6　p. 599-607　2017/11　Research paper (scientific journal)

Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma

Hiroaki Honjo, Yasushi Toh, Makoto Sohda, Shigemasa Suzuki, Kyoichi Kaira, Yoshikatsu Kanai, Shushi Nagamori, Tetsunari Oyama, Takehiko Yokobori, Tatsuya Miyazaki, Hiroyuki Kuwano

ANTICANCER RESEARCH　Vol. 37　No. 8　p. 4147-4155　2017/08　Research paper (scientific journal)

Essential roles of L-type amino acid transporter 1 in syncytiotrophoblast development by presenting fusogenic 4F2hc

Ryuichi Ohgaki, Takahiro Ohmori, Saori Hara, Saya Nakagomi, Masami Kanai-Azuma, Kazuko Kaneda-Nakashima, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai

Molecular and Cellular Biology　Vol. 37　No. 11　2017/06/01　Research paper (scientific journal)

Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma

Eisuke Kume, Tomoko Mutou, Norio Kansaku, Hitoyuki Takahashi, Michael F. Wempe, Masahiro Ikegami, Yoshikatsu Kanai, Hitoshi Endou, Shin Wakui

MICROSCOPY　Vol. 66　No. 3　p. 198-203　2017/06　Research paper (scientific journal)

Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans

Yusuke Masuo, Shushi Nagamori, Aoi Hasegawa, Kazuki Hayashi, Noriyoshi Isozumi, Noritaka Nakamichi, Yoshikatsu Kanai, Yukio Kato

PHARMACEUTICAL RESEARCH　Vol. 34　No. 6　p. 1233-1243　2017/06　Research paper (scientific journal)

Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue IN VIVO METABOLIC TURNOVER ANALYSIS

Hirofumi Nagao, Hitoshi Nishizawa, Takeshi Bamba, Yasumune Nakayama, Noriyoshi Isozumi, Shushi Nagamori, Yoshikatsu Kanai, Yoshimitsu Tanaka, Shunbun Kita, Shiro Fukuda, Tohru Funahashi, Norikazu Maeda, Eiichiro Fukusaki, Iichiro Shimomura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 292　No. 11　p. 4469-4483　2017/03　Research paper (scientific journal)

Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer

Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Yumiko Hori, Kohei Hagiwara, Daisuke Okuzaki, Shinya Oki, Naoki Wada, Jun-ichiro Ikeda, Yoshikatsu Kanai, Eiichi Morii

SCIENTIFIC REPORTS　Vol. 7　2017/03　Research paper (scientific journal)

F-18-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with F-18-FDG and C-11-Methionine PET

Tadashi Watabe, Hayato Ikeda, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Sadahiro Naka, Yasukazu Kanai, Kohei Hagiwara, Masanao Aoki, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　Vol. 44　No. 2　p. 321-331　2017/02　Research paper (scientific journal)

Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer

Taisuke Satoh, Kyoichi Kaira, Kengo Takahashi, Norihumi Takahashi, Yoshikatsu Kanai, Takayuki Asao, Jun Horiguchi, Tetsunari Oyama

ANTICANCER RESEARCH　Vol. 37　No. 2　p. 631-636　2017/02　Research paper (scientific journal)

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

Pornparn Kongpracha, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Kazuko Kaneda, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 2　p. 96-102　2017/02　Research paper (scientific journal)

Prognostic impact of LAT1 and CD98 expression in cutaneous angiosarcoma

A. Shimizu, K. Kaira, Y. Okubo, D. Utsumi, M. Yasuda, H. Tominaga, N. Oriuchi, Y. Kanai, K. Takahashi, O. Ishikawa

NEOPLASMA　Vol. 64　No. 2　p. 283-288　2017　Research paper (scientific journal)

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

Dora C. Tarlungeanu, Elena Deliu, Christoph P. Dotter, Majdi Kara, Philipp Christoph Janiesch, Mariafrancesca Scalise, Michele Galluccio, Mateja Tesulov, Emanuela Morelli, Fatma Mujgan Sonmez, Kaya Bilguvar, Ryuichi Ohgaki, Yoshikatsu Kanai, Anide Johansen, Seham Esharif, Tawfeg Ben-Omran, Meral Topcu, Avner Schlessinger, Cesare Indiveri, Kent E. Duncan, Ahmet Okay Caglayan, Murat Gunel, Joseph G. Gleeson, Gaia Novarino

CELL　Vol. 167　No. 6　p. 1481-+　2016/12　Research paper (scientific journal)

Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy

Shinji Takamatsu, Mayuka Shimomura, Yoshihiro Kamada, Haruka Maeda, Tomoaki Sobajima, Hayato Hikita, Masumi Iijima, Yuta Okamoto, Ryo Misaki, Kazuhito Fujiyama, Shushi Nagamori, Yoshikatsu Kanai, Tetsuo Takehara, Keiji Ueda, Shun'ichi Kuroda, Eiji Miyoshi

GLYCOBIOLOGY　Vol. 26　No. 11　p. 1180-1189　2016/11　Research paper (scientific journal)

Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma

Yasuhiro Ohshima, Kyoichi Kaira, Aiko Yamaguchi, Noboru Oriuchi, Hideyuki Tominaga, Shushi Nagamori, Yoshikatsu Kanai, Takehiko Yokobori, Tatsuya Miyazaki, Takayuki Asao, Yoshito Tsushima, Hiroyuki Kuwano, Noriko S. Ishioka

Cancer Science　Vol. 107　No. 10　p. 1499-1505　2016/10/01　Research paper (scientific journal)

Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 Inhibitor Canagliflozin with SGLT1 and SGLT2: Inhibition Kinetics, Sidedness of Action, and Transporter-Associated Incorporation Accounting for its Pharmacodynamic and Pharmacokinetic Features

Ryuichi Ohgaki, Ling Wei, Kazunori Yamada, Taiki Hara, Chiaki Kuriyama, Suguru Okuda, Kiichiro Ueta, Masaharu Shiotani, Shushi Nagamori, Yoshikatsu Kanai

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 358　No. 1　p. 94-102　2016/07　Research paper (scientific journal)

Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells

Minhui Xu, Shinichi Sakamoto, Jun Matsushima, Toru Kimura, Takeshi Ueda, Atsushi Mizokami, Yoshikatsu Kanai, Tomohiko Ichikawa

JOURNAL OF UROLOGY　Vol. 195　No. 5　p. 1588-1597　2016/05　Research paper (scientific journal)

肥満脂肪組織におけるin vivoメタボロミクス動態解析 グルタミン酸上昇とその病態学的意義

長尾 博文, 西澤 均, 馬場 健史, 中山 泰宗, 永森 收志, 金井 好克, 喜多 俊文, 田中 紀實, 福田 士郎, 前田 法一, 船橋 徹, 福崎 英一郎, 下村 伊一郎

糖尿病　Vol. 59　No. Suppl.1　p. S-139　2016/04

Novel cystine transporter in renal proximal tubule identified as a "missing partner" of cystinuria-related membrane protein rBAT/SLC3A1

Shushi Nagamori, Pattama Wiriyasermkul, Saya Nakagomi, Hirohisa Okuyama, Suguru Okuda, Ryuichi Ohgaki Ohgaki, Yoshikatsu Kanai

FASEB JOURNAL　Vol. 30　2016/04　Research paper (scientific journal)

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

Hirotaka Matsuo, Ken Yamamoto, Hirofumi Nakaoka, Akiyoshi Nakayama, Masayuki Sakiyama, Toshinori Chiba, Atsushi Takahashi, Takahiro Nakamura, Hiroshi Nakashima, Yuzo Takada, Inaho Danjoh, Seiko Shimizu, Junko Abe, Yusuke Kawamura, Sho Terashige, Hiraku Ogata, Seishiro Tatsukawa, Guang Yin, Rieko Okada, Emi Morita, Mariko Naito, Atsumi Tokumasu, Hiroyuki Onoue, Keiichi Iwaya, Toshimitsu Ito, Tappei Takada, Katsuhisa Inoue, Yukio Kato, Yukio Nakamura, Yutaka Sakurai, Hiroshi Suzuki, Yoshikatsu Kanai, Tatsuo Hosoya, Nobuyuki Hamajima, Ituro Inoue, Michiaki Kubo, Kimiyoshi Ichida, Hiroshi Ooyama, Toru Shimizu, Nariyoshi Shinomiya

ANNALS OF THE RHEUMATIC DISEASES　Vol. 75　No. 4　p. 652-659　2016/04　Research paper (scientific journal)

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

Fredrick J. Rosario, Kris Genelyn Dimasuay, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson

CLINICAL SCIENCE　Vol. 130　No. 7　p. 499-512　2016/04　Research paper (scientific journal)

Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling

Shushi Nagamori, Pattama Wiriyasermkul, Suguru Okuda, Naoto Kojima, Yoshiyuki Hari, Shigeki Kiyonaka, Yasuo Mori, Hideyuki Tominaga, Ryuichi Ohgaki, Yoshikatsu Kanai

AMINO ACIDS　Vol. 48　No. 4　p. 1045-1058　2016/04　Research paper (scientific journal)

Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging

Ling Wei, Hideyuki Tominaga, Ryuichi Ohgaki, Pattama Wiriyasermkul, Kohei Hagiwara, Suguru Okuda, Kyoichi Kaira, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai

Cancer Science　Vol. 107　No. 3　p. 347-352　2016/03/01　Research paper (scientific journal)

Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma

Hiroaki Honjo, Kyoichi Kaira, Tatsuya Miyazaki, Takehiko Yokobori, Yoshikatsu Kanai, Shushi Nagamori, Tetsunari Oyama, Takayuki Asao, Hiroyuki Kuwano

JOURNAL OF SURGICAL ONCOLOGY　Vol. 113　No. 4　p. 381-389　2016/03　Research paper (scientific journal)

Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals (vol 5, 15057, 2015)

Junji Furukawa, Katsuhisa Inoue, Junya Maeda, Tomoya Yasujima, Kinya Ohta, Yoshikatsu Kanai, Tappei Takada, Hirotaka Matsuo, Hiroaki Yuasa

SCIENTIFIC REPORTS　Vol. 6　2016/03

Transport of 3-fluoro-L-alpha-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [F-18]FAMT positron emission tomography

Ling Wei, Hideyuki Tominaga, Ryuichi Ohgaki, Pattama Wiriyasermkul, Kohei Hagiwara, Suguru Okuda, Kyoichi Kaira, Yukio Kato, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 130　No. 2　p. 101-109　2016/02　Research paper (scientific journal)

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

Shushi Nagamori, Pattama Wiriyasermkul, Meritxell Espino Guarch, Hirohisa Okuyama, Saya Nakagomi, Kenjiro Tadagaki, Yumiko Nishinaka, Susanna Bodoy, Kazuaki Takafuji, Suguru Okuda, Junko Kurokawa, Ryuichi Ohgaki, Virginia Nunes, Manuel Palacín, Yoshikatsu Kanai

Proceedings of the National Academy of Sciences of the United States of America　Vol. 113　No. 3　p. 775-780　2016/01/19　Research paper (scientific journal)

SGLT2 Inhibitors: Its Usefulness From Pharmacological Point of View

Kanai Yoshikatsu

Journal of the Japan Diabetes Society　Vol. 59　No. 9　p. 628-631　2016

SGLT2 inhibitors: Anti-diabetic drug discovery based on transporter inhibition

Yoshikatsu Kanai

Drug Delivery System　Vol. 31　No. 5　p. 450-461　2016　Research paper (scientific journal)

Expression of a human NPT1/SLC17A1 missense variant which increases urate export

Masayuki Sakiyama, Hirotaka Matsuo, Shushi Nagamori, Wei Ling, Yusuke Kawamura, Akiyoshi Nakayama, Toshihide Higashino, Toshinori Chiba, Kimiyoshi Ichida, Yoshikatsu Kanai, Nariyoshi Shinomiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS　Vol. 35　No. 10-12　p. 536-542　2016　Research paper (scientific journal)

腎尿酸排泄輸送体遺伝子NPT1の機能獲得型変異は痛風発症に保護的に働く

棚橋 勇輝, 松尾 洋孝, 千葉 俊周, 河村 優輔, 永森 收志, 中山 昌喜, 中村 好宏, 崎山 真幸, 内藤 真理子, 尾田 高志, 熊谷 裕生, 清水 徹, 金井 好克, 四ノ宮 成祥

防衛衛生　Vol. 63　No. 別冊　p. 74-74　2015/12

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Catalytic receptors

Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 5979-6023　2015/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: G protein-coupled receptors

Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 5744-5869　2015/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Enzymes

Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 6024-6109　2015/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Ligand-gated ion channels

Stephen P. H. Alexander, John A. Peters, Eamonn Kelly, Neil Marrion, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 5870-5903　2015/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Nuclear hormone receptors

Stephen P. H. Alexander, John A. Cidlowski, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 5956-5978　2015/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Transporters

Stephen P. H. Alexander, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 6110-6202　2015/12　Research paper (scientific journal)

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Overview

Stephen P. H. Alexander, Eamonn Kelly, Neil Marrion, John A. Peters, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Christopher Southan, O. Peter Buneman, William A. Catterall, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Grace Fan, John C. McGrath, Michael Spedding, Jamie A. Davies, R. Aldrich, B. Attali, M. Back, N. M. Barnes, R. Bathgate, P. M. Beart, E. Becirovic, M. Biel, N. J. Birdsall, D. Boison, H. Brauner-Osborne, S. Broeer, C. Bryant, G. Burnstock, T. Burris, D. Cain, G. Calo, S. L. Chan, K. G. Chandy, N. Chiang, S. Christakos, A. Christopoulos, J. J. Chun, J. -J. Chung, D. E. Clapham, M. A. Connor, L. Coons, H. M. Cox, F. M. Dautzenberg, G. Dent, S. D. Douglas, M. L. Dubocovich, D. P. Edwards, R. Farndale, T. M. Fong, D. Forrest, C. J. Fowler, P. Fuller, R. R. Gainetdinov, M. A. Gershengorn, A. Goldin, S. A. N. Goldstein, S. L. Grimm, S. Grissmer, A. L. Gundlach, B. Hagenbuch, J. R. Hammond, J. C. Hancox, S. Hartig, R. L. Hauger, D. L. Hay, T. Hebert, A. N. Hollenberg, N. D. Holliday, D. Hoyer, A. P. Ijzerman, K. I. Inui, S. Ishii, K. A. Jacobson, L. Y. Jan, G. E. Jarvis, R. Jensen, A. Jetten, R. Jockers, L. K. Kaczmarek, Y. Kanai, H. S. Kang, S. Karnik, I. D. Kerr, K. S. Korach, C. A. Lange, D. Larhammar, F. Leeb-Lundberg, R. Leurs, S. J. Lolait, D. Macewan, J. J. Maguire, J. M. May, J. Mazella, C. A. McArdle, D. P. McDonnell, M. C. Michel, L. J. Miller, V. Mitolo, T. Monie, P. N. Monk, B. Mouillac, P. M. Murphy, J. -L. Nahon, J. Nerbonne, C. G. Nichols, X. Norel, R. Oakley, S. Offermanns, L. G. Palmer, M. A. Panaro, E. Perez-Reyes, R. G. Pertwee, J. W. Pike, J. P. Pin, S. Pintor, L. D. Plant, D. R. Poyner, E. R. Prossnitz, S. Pyne, D. Ren, J. K. Richer, P. Rondard, R. A. Ross, H. Sackin, R. Safi, M. C. Sanguinetti, C. A. Sartorius, D. L. Segaloff, F. M. Sladek, G. Stewart, L. A. Stoddart, J. Striessnig, R. J. Summers, Y. Takeda, M. Tetel, L. Toll, J. S. Trimmer, M. -J. Tsai, S. Y. Tsai, S. Tucker, T. B. Usdin, J. -P. Vilargada, M. Vore, D. T. Ward, S. G. Waxman, P. Webb, A. D. Wei, N. Weigel, G. B. Willars, C. Winrow, S. S. Wong, H. Wulff, R. D. Ye, M. Young, J. -M. Zajac

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 172　No. 24　p. 5729-5743　2015/12　Research paper (scientific journal)

CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma

Miroru Toyoda, Kyoichi Kaira, Masato Shino, Koichi Sakakura, Katsumasa Takahashi, Yukihiro Takayasu, Hideyuki Tominaga, Noboru Oriuchi, Osamu Nikkuni, Masami Suzuki, Misa Iijima, Norifumi Tsukamoto, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Kazuaki Chikamatsu

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK　Vol. 37　No. 11　p. 1569-1574　2015/11　Research paper (scientific journal)

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma

Akira Shimizu, Kyoichi Kaira, Madoka Kato, Masahito Yasuda, Ayumi Takahashi, Hideyuki Tominaga, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Takayuki Asao, Osamu Ishikawa

MELANOMA RESEARCH　Vol. 25　No. 5　p. 399-405　2015/10　Research paper (scientific journal)

Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals

Junji Furukawa, Katsuhisa Inoue, Junya Maeda, Tomoya Yasujima, Kinya Ohta, Yoshikatsu Kanai, Tappei Takada, Hirotaka Matsuo, Hiroaki Yuasa

SCIENTIFIC REPORTS　Vol. 5　2015/10　Research paper (scientific journal)

Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma

Masashi Namikawa, Satoru Kakizaki, Kyoichi Kaira, Hiroki Tojima, Yuichi Yamazaki, Norio Horiguchi, Ken Sato, Noboru Oriuchi, Hideyuki Tominaga, Yutaka Sunose, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Izumi Takeyoshi, Masanobu Yamada

HEPATOLOGY RESEARCH　Vol. 45　No. 9　p. 1014-1022　2015/09　Research paper (scientific journal)

Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma

Osamu Nikkuni, Kyoichi Kaira, Minoru Toyoda, Masato Shino, Koichi Sakakura, Katsumasa Takahashi, Hideyuki Tominaga, Noboru Oriuchi, Masami Suzuki, Misa Iijima, Takayuki Asao, Masahiko Nishiyama, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Kazuaki Chikamatsu

PATHOLOGY & ONCOLOGY RESEARCH　Vol. 21　No. 4　p. 1175-1181　2015/09　Research paper (scientific journal)

L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors

Hiromi Koshi, Takaaki Sano, Tadashi Handa, Takashi Yanagawa, Kenichi Saitou, Shushi Nagamori, Yoshikatsu Kanai, Kenji Takagishi, Tetsunari Oyama

PATHOLOGY INTERNATIONAL　Vol. 65　No. 9　p. 460-467　2015/09　Research paper (scientific journal)

Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea

Satoru Uetsuka, Genki Ogata, Shushi Nagamori, Noriyoshi Isozumi, Fumiaki Nin, Takamasa Yoshida, Shizuo Komune, Tadashi Kitahara, Yoshiaki Kikkawa, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino

EUROPEAN JOURNAL OF NEUROSCIENCE　Vol. 42　No. 3　p. 1984-2002　2015/08　Research paper (scientific journal)

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth

Fredrick J. Rosario, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson

OBESITY　Vol. 23　No. 8　p. 1663-1670　2015/08　Research paper (scientific journal)

Analysis of the interaction of leucine derivatives with leucine binding protein toward understanding of mTOR activation by leucine

Suguru Okuda, Pattama Wiriyasermkul, Naoto Kojima, Shushi Nagamori, Yoshikatsu Kanai

Journal of Pharmacological Sciences　Vol. 128　No. 3, Supplement,　p. S212-S212　2015/07　Research paper (international conference proceedings)

Expression and functional characterisation of System L amino acid transporters in the human term placenta

Francesca Gaccioli, Irving L. M. H. Aye, Sara Roos, Susanne Lager, Vanessa I. Ramirez, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY　Vol. 13　2015/06　Research paper (scientific journal)

Development of a Widely Usable Amino Acid Tracer: Br-76-alpha-Methyl-Phenylalanine for Tumor PET Imaging

Hirofumi Hanaoka, Yasuhiro Ohshima, Yurika Suzuki, Aiko Yamaguchi, Shigeki Watanabe, Tomoya Uehara, Shushi Nagamori, Yoshikatsu Kanai, Noriko S. Ishioka, Yoshito Tsushima, Keigo Endo, Yasushi Arano

JOURNAL OF NUCLEAR MEDICINE　Vol. 56　No. 5　p. 791-797　2015/05　Research paper (scientific journal)

ヒト肝癌細胞FLC-4におけるB型肝炎ウイルスレセプターNTCPの発現と誘導に関する検討

松浦 知和, 松本 喜弘, 永森 収志, 渡士 幸一, 金井 好克, 小嶋 聡一, 脇田 隆字, 相崎 英樹

肝臓　Vol. 56　No. Suppl.1　p. A402-A402　2015/04

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB(0,+), LAT1 and LAT2

Printip Wongthai, Kohei Hagiwara, Yurika Miyoshi, Pattama Wiriyasermkul, Ling Wei, Ryuichi Ohgaki, Itsuro Kato, Kenji Hamase, Shushi Nagamori, Yoshikatsu Kanai

CANCER SCIENCE　Vol. 106　No. 3　p. 279-286　2015/03　Research paper (scientific journal)

Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of Sodium Taurocholate Cotransporting Polypeptide (NTCP) Expression

Senko Tsukuda, Koichi Watashi, Masashi Iwamoto, Ryosuke Suzuki, Hideki Aizaki, Maiko Okada, Masaya Sugiyama, Soichi Kojima, Yasuhito Tanaka, Masashi Mizokami, Jisu Li, Shuping Tong, Takaji Wakita

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 9　p. 5673-5684　2015/02　Research paper (scientific journal)

Proteomic analysis of the stria vascuralis that drives membrane transport system of the mammalian cochlea

Uetsuka Satoru, Ogata Genki, Nagamori Shushi, Isozumi Noriyoshi, Yoshida Takamasa, Nin Fumiaki, Kitahara Tadashi, Kikkawa Yoshiaki, Inohara Hidenori, Kanai Yoshikatsu, Hibino Hiroshi

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2015　p. 191-191　2015

Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma

Kyoichi Kaira, Yutaka Sunose, Kazuhisa Arakawa, Noriaki Sunaga, Kimihiro Shimizu, Hideyuki Tominaga, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Izumi Takeyoshi

HISTOPATHOLOGY　Vol. 66　No. 2　p. 234-243　2015/01　Research paper (scientific journal)

NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-Function Variant Decreases the Risk of Renal Underexcretion Gout

Toshinori Chiba, Hirotaka Matsuo, Yusuke Kawamura, Shushi Nagamori, Takashi Nishiyama, Ling Wei, Akiyoshi Nakayama, Takahiro Nakamura, Masayuki Sakiyama, Tappei Takada, Yutaka Taketani, Shino Suma, Mariko Naito, Takashi Oda, Hiroo Kumagai, Yoshinori Moriyama, Kimiyoshi Ichida, Toru Shimizu, Yoshikatsu Kanai, Nariyoshi Shinomiya

ARTHRITIS & RHEUMATOLOGY　Vol. 67　No. 1　p. 281-287　2015/01　Research paper (scientific journal)

Relationship between CD147 and expression of amino acid transporters (LAT1 and ASCT2) in patients with pancreatic cancer

Kyoichi Kaira, Kazuhisa Arakawa, Kimihiro Shimizu, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Izumi Takeyoshi

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH　Vol. 7　No. 2　p. 356-363　2015　Research paper (scientific journal)

Clinical significance of coexpression of L-type amino acid transporter 1 (LAT1) and ASC amino acid transporter 2 (ASCT2) in lung adenocarcinoma

Tomohiro Yazawa, Kimihiro Shimizu, Kyoichi Kaira, Toshiteru Nagashima, Yoichi Ohtaki, Jun Atsumi, Kai Obayashi, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Izumi Takeyoshi

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH　Vol. 7　No. 6　p. 1126-1139　2015　Research paper (scientific journal)

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in patients with ovarian tumors

Kyoichi Kaira, Kazuto Nakamura, Takashi Hirakawa, Hisao Imai, Hideyuki Tominaga, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai, Norifumi Tsukamoto, Tetsunari Oyama, Takayuki Asao, Takashi Minegishi

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH　Vol. 7　No. 6　p. 1161-1171　2015　Research paper (scientific journal)

CD98 is a promising prognostic biomarker in biliary tract cancer

Kyoichi Kaira, Yutaka Sunose, Noboru Oriuchi, Yoshikatsu Kanai, Izumi Takeyoshi

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL　Vol. 13　No. 6　p. 654-657　2014/12　Research paper (scientific journal)

Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma

Atsushi Isoda, Kyoichi Kaira, Masanori Iwashina, Noboru Oriuchi, Hideyuki Tominaga, Shushi Nagamori, Yoshikatsu Kanai, Tetsunari Oyama, Takayuki Asao, Morio Matsumoto, Morio Sawamura

CANCER SCIENCE　Vol. 105　No. 11　p. 1496-1502　2014/11　Research paper (scientific journal)

Development of a PET/Cerenkov-light hybrid imaging system

Seiichi Yamamoto, Fuka Hamamura, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Hiroshi Watabe, Katsuhiko Kato, Yoshimune Ogata, Jun Hatazawa

MEDICAL PHYSICS　Vol. 41　No. 9　2014/09　Research paper (scientific journal)

Cyclophilin Inhibitors Reduce Phosphorylation of RNA-Dependent Protein Kinase to Restore Expression of IFN-Stimulated Genes in HCV-Infected Cells

Takuji Daito, Koichi Watashi, Ann Sluder, Hirofumi Ohashi, Syo Nakajima, Katyna Borroto-Esoda, Takashi Fujita, Takaji Wakita

GASTROENTEROLOGY　Vol. 147　No. 2　p. 463-472　2014/08　Research paper (scientific journal)

Glucocorticoid mediates the transcription of OAT-PG, a kidney-specific prostaglandin transporter

Ryo Hatano, Hiroki Mukouchi, Yosuke Matsumoto, Kotoku Kawaguchi, Itsuro Kazama, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Shin Kurosawa, Yoshikatsu Kanai, Mitsunobu Matsubara, Shinji Asano

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　Vol. 466　No. 5　p. 925-935　2014/05　Research paper (scientific journal)

Cyclosporin A and Its Analogs Inhibit Hepatitis B Virus Entry Into Cultured Hepatocytes Through Targeting a Membrane Transporter, Sodium Taurocholate Cotransporting Polypeptide (NTCP)

Koichi Watashi, Ann Sluder, Takuji Daito, Satoko Matsunaga, Akihide Ryo, Shushi Nagamori, Masashi Iwamoto, Syo Nakajima, Senko Tsukuda, Katyna Borroto-Esoda, Masaya Sugiyama, Yasuhito Tanaka, Yoshikatsu Kanai, Hiroyuki Kusuhara, Masashi Mizokami, Takaji Wakita

HEPATOLOGY　Vol. 59　No. 5　p. 1726-1737　2014/05　Research paper (scientific journal)

Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer

M. Toyoda, K. Kaira, Y. Ohshima, N. S. Ishioka, M. Shino, K. Sakakura, Y. Takayasu, K. Takahashi, H. Tominaga, N. Oriuchi, S. Nagamori, Y. Kanai, T. Oyama, K. Chikamatsu

BRITISH JOURNAL OF CANCER　Vol. 110　No. 10　p. 2506-2513　2014/05　Research paper (scientific journal)

Biological significance of fluorine-18-alpha-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer

S. Suzuki, K. Kaira, Y. Ohshima, N. S. Ishioka, M. Sohda, T. Yokobori, T. Miyazaki, N. Oriuchi, H. Tominaga, Y. Kanai, N. Tsukamoto, T. Asao, Y. Tsushima, T. Higuchi, T. Oyama, H. Kuwano

BRITISH JOURNAL OF CANCER　Vol. 110　No. 8　p. 1985-1991　2014/04　Research paper (scientific journal)

Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A

Shinya Matsuzaki, Takayuki Enomoto, Satoshi Serada, Kiyoshi Yoshino, Shushi Nagamori, Akiko Morimoto, Takuhei Yokoyama, Ayako Kim, Toshihiro Kimura, Yutaka Ueda, Masami Fujita, Minoru Fujimoto, Yoshikatsu Kanai, Tadashi Kimura, Tetsuji Naka

INTERNATIONAL JOURNAL OF CANCER　Vol. 134　No. 8　p. 1796-1809　2014/04　Research paper (scientific journal)

ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer

K. Shimizu, K. Kaira, Y. Tomizawa, N. Sunaga, O. Kawashima, N. Oriuchi, H. Tominaga, S. Nagamori, Y. Kanai, M. Yamada, T. Oyama, I. Takeyoshi

BRITISH JOURNAL OF CANCER　Vol. 110　No. 8　p. 2030-2039　2014/04　Research paper (scientific journal)

Down-regulation of placental mTOR, insulin/IGF- I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

Jovita V. Kavitha, Fredrick J. Rosario, Mark J. Nijland, Thomas J. McDonald, Guoyao Wu, Yoshikatsu Kanai, Theresa L. Powell, Peter W. Nathanielsz, Thomas Jansson

FASEB JOURNAL　Vol. 28　No. 3　p. 1294-1305　2014/03　Research paper (scientific journal)

JPH203, an L-Type Amino Acid Transporter 1-Selective Compound, Induces Apoptosis of YD-38 Human Oral Cancer Cells

Dae-Woong Yun, Seul Ah Lee, Min-Gyeong Park, Jae-Sung Kim, Sun-Kyoung Yu, Mi-Ra Park, Su-Gwan Kim, Ji-Su Oh, Chun Sung Kim, Heung-Joong Kim, Jin-Soo Kim, Hong Sung Chun, Yoshikatsu Kanai, Hitoshi Endou, Michael F. Wempe, Do Kyung Kim

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 124　No. 2　p. 208-217　2014/02　Research paper (scientific journal)

A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility

Masayuki Sakiyama, Hirotaka Matsuo, Seiko Shimizu, Toshinori Chiba, Akiyoshi Nakayama, Yuzo Takada, Takahiro Nakamura, Tappei Takada, Emi Morita, Mariko Naito, Kenji Wakai, Hiroki Inoue, Seishiro Tatsukawa, Junki Sato, Kazumi Shimono, Toshiaki Makino, Takahiro Satoh, Hiroshi Suzuki, Yoshikatsu Kanai, Nobuyuki Hamajima, Yutaka Sakurai, Kimiyoshi Ichida, Toru Shimizu, Nariyoshi Shinomiya

HUMAN CELL　Vol. 27　No. 1　p. 1-4　2014/01　Research paper (scientific journal)

Nicotine induces dendritic spine remodeling in cultured hippocampal neurons

Akira Oda, Kanato Yamagata, Saya Nakagomi, Hiroshi Uejima, Pattama Wiriyasermkul, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai, Hidekazu Tanaka

Journal of Neurochemistry　Vol. 128　No. 2　p. 246-255　2014/01　Research paper (scientific journal)

IDENTIFICATION OF A HYPOURICEMIA PATIENT WITH SLC2A9 R380W, A PATHOGENIC MUTATION FOR RENAL HYPOURICEMIA TYPE 2

Toshinori Chiba, Hirotaka Matsuo, Shushi Nagamori, Akiyoshi Nakayama, Yusuke Kawamura, Seiko Shimizu, Masayuki Sakiyama, Makoto Hosoyamada, Sayo Kawai, Rieko Okada, Nobuyuki Hamajima, Yoshikatsu Kanai, Nariyoshi Shinomiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS　Vol. 33　No. 4-6　p. 261-265　2014　Research paper (scientific journal)

Amino acid transporters in cancer

Shushi Nagamori, Yoshikatsu Kanai

Seikagaku　Vol. 86　No. 3　p. 338-344　2014

THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW

Stephen P. H. Alexander, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, John C. McGrath, William A. Catterall, Michael Spedding, John A. Peters, Anthony J. Harmar

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 170　No. 8　p. 1449-1458　2013/12　Research paper (scientific journal)

YY1 binds to α-synuclein 3′-flanking region SNP and stimulates antisense noncoding RNA expression

Ikuko Mizuta, Kazuaki Takafuji, Yuko Ando, Wataru Satake, Motoi Kanagawa, Kazuhiro Kobayashi, Shushi Nagamori, Takayuki Shinohara, Chiyomi Ito, Mitsutoshi Yamamoto, Nobutaka Hattori, Miho Murata, Yoshikatsu Kanai, Shigeo Murayama, Masanori Nakagawa, Tatsushi Toda

Journal of Human Genetics　Vol. 58　No. 11　p. 711-719　2013/11　Research paper (scientific journal)

腎細胞癌におけるLAT1/4F2hcの発現と予後との関連(Upregulation of LAT1/4F2hc correlated with prognosis in Renal Cell Carcinoma)

坂本 信一, Ahmed Nasar, 徐 旻恵, 巣山 貴仁, 内海 孝信, 二瓶 直樹, 遠藤 仁, 金井 好克, 市川 智彦

日本癌学会総会記事　Vol. 72回　p. 435-435　2013/10

Clinicopathological Significance of L-type Amino Acid Transporter 1 (LAT1) Expression in Patients with Adenoid Cystic Carcinoma

Kyoichi Kaira, Minoru Toyoda, Masato Shino, Koichi Sakakura, Katsumasa Takahashi, Hideyuki Tominaga, Noboru Oriuchi, Yoshikatsu Kanai, Tetsunari Oyama, Kazuaki Chikamatsu

PATHOLOGY & ONCOLOGY RESEARCH　Vol. 19　No. 4　p. 649-656　2013/10　Research paper (scientific journal)

Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

Kyoichi Kaira, Yutaka Sunose, Yasuhiro Ohshima, Noriko S. Ishioka, Kazuhisa Arakawa, Tetsushi Ogawa, Noriaki Sunaga, Kimihiro Shimizu, Hideyuki Tominaga, Noboru Oriuchi, Hideaki Itoh, Shushi Nagamori, Yoshikatsu Kanai, Aiko Yamaguchi, Atsuki Segawa, Munenori Ide, Masatomo Mori, Tetsunari Oyama, Izumi Takeyoshi

BMC CANCER　Vol. 13　2013/10　Research paper (scientific journal)

The small SLC43 family: Facilitator system L amino acid transporters and the orphan EEG1

Susanna Bodoy, Dimitrios Fotiadis, Claudia Stoeger, Yoshikatsu Kanai, Manuel Palacin

MOLECULAR ASPECTS OF MEDICINE　Vol. 34　No. 2-3　p. 638-645　2013/04

The SLC1 high-affinity glutamate and neutral amino acid transporter family

Yoshikatsu Kanai, Benjamin Clémençon, Alexandre Simonin, Michele Leuenberger, Martin Lochner, Martin Weisstanner, Matthias A. Hediger

Molecular Aspects of Medicine　Vol. 34　No. 2-3　p. 108-120　2013/04

The SLC3 and SLC7 families of amino acid transporters

Dimitrios Fotiadis, Yoshikatsu Kanai, Manuel Palacin

MOLECULAR ASPECTS OF MEDICINE　Vol. 34　No. 2-3　p. 139-158　2013/04

L-type amino acid transporter 1 expression is highly correlated with Gleason score in prostate cancer.

Segawa A, Nagamori S, Kanai Y, Masawa N, Oyama T

Molecular and clinical oncology　Vol. 1　No. 2　p. 274-280　2013/03

Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

Fredrick J. Rosario, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson

JOURNAL OF PHYSIOLOGY-LONDON　Vol. 591　No. 3　p. 609-625　2013/02　Research paper (scientific journal)

Biological evaluation of 3-[18F]fluoro-α-methyl-d-tyrosine (d-[18F]FAMT) as a novel amino acid tracer for positron emission tomography

Yasuhiro Ohshima, Hirofumi Hanaoka, Hideyuki Tominaga, Yoshikatsu Kanai, Kyoichi Kaira, Aiko Yamaguchi, Shushi Nagamori, Noboru Oriuchi, Yoshito Tsushima, Keigo Endo, Noriko S. Ishioka

Annals of Nuclear Medicine　Vol. 27　No. 4　p. 314-324　2013　Research paper (scientific journal)

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout

Hirotaka Matsuo, Kimiyoshi Ichida, Tappei Takada, Akiyoshi Nakayama, Hiroshi Nakashima, Takahiro Nakamura, Yusuke Kawamura, Yuzo Takada, Ken Yamamoto, Hiroki Inoue, Yuji Oikawa, Mariko Naito, Asahi Hishida, Kenji Wakai, Chisa Okada, Seiko Shimizu, Masayuki Sakiyama, Toshinori Chiba, Hiraku Ogata, Kazuki Niwa, Makoto Hosoyamada, Atsuyoshi Mori, Nobuyuki Hamajima, Hiroshi Suzuki, Yoshikatsu Kanai, Yutaka Sakurai, Tatsuo Hosoya, Toru Shimizu, Nariyoshi Shinomiya

Scientific Reports　Vol. 3　2013　Research paper (scientific journal)

Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma

Aiko Nobusawa, Mai Kim, Kyoichi Kaira, Go Miyashita, Akihide Negishi, Noboru Oriuchi, Tetsuya Higuchi, Yoshito Tsushima, Yoshikatsu Kanai, Satoshi Yokoo, Tetsunari Oyama

European Journal of Nuclear Medicine and Molecular Imaging　Vol. 40　No. 11　p. 1692-1700　2013　Research paper (scientific journal)

Decreased Expression of a Novel Prostaglandin Transporter, OAT-PG, Facilitates Renocortical PGE(2) Accumulation during Rat Pregnancy

Itsuro Kazama, Mitsunobu Matsubara, Yoshikatsu Kanai, Ryo Hatano, Shinji Asano, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Shin Kurosawa, Yoshio Maruyama

GYNECOLOGIC AND OBSTETRIC INVESTIGATION　Vol. 76　No. 3　p. 163-170　2013　Research paper (scientific journal)

IUPHAR-DB: updated database content and new features

Joanna L. Sharman, Helen E. Benson, Adam J. Pawson, Veny Lukito, Chidochangu P. Mpamhanga, Vincent Bombail, Anthony P. Davenport, John A. Peters, Michael Spedding, Anthony J. Harmar

NUCLEIC ACIDS RESEARCH　Vol. 41　No. D1　p. D1083-D1088　2013/01　Research paper (scientific journal)

NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane

Kohei Hagiwara, Shushi Nagamori, Yasuhiro M. Umemura, Ryuichi Ohgaki, Hidekazu Tanaka, Daisuke Murata, Saya Nakagomi, Kazuko H. Nomura, Eriko Kage-Nakadai, Shohei Mitani, Kazuya Nomura, Yoshikatsu Kanai

PLoS ONE　Vol. 7　No. 8　2012/08/15　Research paper (scientific journal)

Transport of 3-Fluoro-L-alpha-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET

Pattama Wiriyasermkul, Shushi Nagamori, Hideyuki Tominaga, Noboru Oriuchi, Kyoichi Kaira, Hidekazu Nakao, Takeru Kitashoji, Ryuichi Ohgaki, Hidekazu Tanaka, Hitoshi Endou, Keigo Endo, Hiroyuki Sakurai, Yoshikatsu Kanai

JOURNAL OF NUCLEAR MEDICINE　Vol. 53　No. 8　p. 1253-1261　2012/08　Research paper (scientific journal)

Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With alpha-Alkyl Moieties

Narakorn Khunweeraphong, Shushi Nagamori, Pattama Wiriyasermku, Yumiko Nishinaka, Printip Wongthai, Ryuichi Ohgaki, Hidekazu Tanaka, Hideyuki Tominaga, Hiroyuki Sakurai, Yoshikatsu Kanai

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 119　No. 4　p. 368-380　2012/08　Research paper (scientific journal)

Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer

K. Kaira, Y. Sunose, K. Arakawa, T. Ogawa, N. Sunaga, K. Shimizu, H. Tominaga, N. Oriuchi, H. Itoh, S. Nagamori, Y. Kanai, A. Segawa, M. Furuya, M. Mori, T. Oyama, I. Takeyoshi

BRITISH JOURNAL OF CANCER　Vol. 107　No. 4　p. 632-638　2012/08　Research paper (scientific journal)

Linkage of N-cadherin to multiple cytoskeletal elements revealed by a proteomic approach in hippocampal neurons

Hidekazu Tanaka, Kazuaki Takafuji, Akihiko Taguchi, Pattama Wiriyasermkul, Ryuichi Ohgaki, Shushi Nagamori, Pann-Ghill Suh, Yoshikatsu Kanai

NEUROCHEMISTRY INTERNATIONAL　Vol. 61　No. 2　p. 240-250　2012/07　Research paper (scientific journal)

Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth

Fredrick J. Rosario, Michael A. Schumacher, Jean Jiang, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson

JOURNAL OF PHYSIOLOGY-LONDON　Vol. 590　No. 6　p. 1495-1509　2012/03　Research paper (scientific journal)

Sex hormones induce a gender-related difference in renal expression of a novel prostaglandin transporter, OAT-PG, influencing basal PGE 2 concentration

Ryo Hatano, Kimitaka Onoe, Masaya Obara, Mitsunobu Matsubara, Yoshikatsu Kanai, Shigeaki Muto, Shinji Asano

American Journal of Physiology - Renal Physiology　Vol. 302　No. 3　p. F342-F349　2012/02　Research paper (scientific journal)

Sex hormones induce a gender-related difference in renal expression of a novel prostaglandin transporter, OAT-PG, influencing basal PGE(2) concentration

Ryo Hatano, Kimitaka Onoe, Masaya Obara, Mitsunobu Matsubara, Yoshikatsu Kanai, Shigeaki Muto, Shinji Asano

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 302　No. 3　p. F342-F349　2012/02　Research paper (scientific journal)

Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis

Mio Furuya, Jun Horiguchi, Hiroki Nakajima, Yoshikatsu Kanai, Tetsunari Oyama

CANCER SCIENCE　Vol. 103　No. 2　p. 382-389　2012/02　Research paper (scientific journal)

Comprehensive variability analysis of small intestine transporters by quantitative proteomics

Nishiyama Takashi, Nagamori Shushi, Takafuji Kazuaki, Kanai Yoshikatsu

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2012　p. 101-101　2012

Cancer drug delivery targeting amino acid transporters

Yoshikatsu Kanai

Drug Delivery System　Vol. 27　No. 5　p. 342-349　2012　Research paper (scientific journal)

How to use the IUPHAR receptor database to navigate pharmacological data.

Mpamhanga CP, Sharman JL, Harmar AJ, NC-IUPHAR

Methods Mol Biol.　Vol. 897　p. 15-29　2012　Research paper (scientific journal)

L-Type Amino Acid Transporter 1 (LAT1) Expression in Malignant Pleural Mesothelioma

Kyoichi Kaira, Noboru Oriuchi, Toshiaki Takahashi, Kazuo Nakagawa, Yasuhisa Ohde, Takehiro Okumura, Haruyasu Murakami, Takehito Shukuya, Hirotsugu Kenmotsu, Tateaki Naito, Yoshikatsu Kanai, Masahiro Endo, Haruhiko Kondo, Takashi Nakajima, Nobuyuki Yamamoto

ANTICANCER RESEARCH　Vol. 31　No. 12　p. 4075-4082　2011/12　Research paper (scientific journal)

A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans

Reina Aoki, Tatsurou Yagami, Hiroyuki Sasakura, Ken-ichi Ogura, Yasuhiro Kajihara, Masakazu Ibi, Takeaki Miyamae, Fumio Nakamura, Taro Asakura, Yoshikatsu Kanai, Yoshimi Misu, Yuichi Iino, Marina Ezcurra, William R. Schafer, Ikue Mori, Yoshio Goshima

JOURNAL OF NEUROSCIENCE　Vol. 31　No. 46　p. 16603-16610　2011/11　Research paper (scientific journal)

Relationship between LAT1 Expression and Response to Platinum-based Chemotherapy in Non-small Cell Lung Cancer Patients with Postoperative Recurrence

Kyoichi Kaira, Toshiaki Takahashi, Haruyasu Murakami, Takehito Shukuya, Hirotsugu Kenmotsu, Tateaki Naito, Noboru Oriuchi, Yoshikatsu Kanai, Masahiro Endo, Haruhiko Kondo, Takashi Nakajima, Nobuyuki Yamamoto

ANTICANCER RESEARCH　Vol. 31　No. 11　p. 3775-3782　2011/11　Research paper (scientific journal)

足場タンパク質を介したNa+依存アニオン輸送体と尿酸-アニオン交換体の機能共役

永森 收志, 梅村 康浩, Wiriyasermkul Pattama, 中込 咲綾, 西中 由美子, 高藤 和輝, 大垣 隆一, 金井 好克

日本生化学会大会プログラム・講演要旨集　Vol. 84回　p. 1S5a-6　2011/09

Transportsomes and channelsomes Are they functional units for physiological responses?

Yasuo Mori, Shigeki Kiyonaka, Yoshikatsu Kanai

CHANNELS　Vol. 5　No. 5　p. 385-388　2011/09

Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis

Ryota Kurayama, Noriko Ito, Yukino Nishibori, Daisuke Fukuhara, Yoshihiro Akimoto, Eiji Higashihara, Yasuhito Ishigaki, Yoshimichi Sai, Ken-ichi Miyamoto, Hitoshi Endou, Yoshikatsu Kanai, Kunimasa Yan

LABORATORY INVESTIGATION　Vol. 91　No. 7　p. 992-1006　2011/07　Research paper (scientific journal)

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

Fredrick J. Rosario, Nina Jansson, Yoshikatsu Kanai, Puttur D. Prasad, Theresa L. Powell, Thomas Jansson

ENDOCRINOLOGY　Vol. 152　No. 3　p. 1119-1129　2011/03　Research paper (scientific journal)

LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer

Kyoichi Kaira, Noboru Oriuchi, Toshiaki Takahashi, Kazuo Nakagawa, Yasuhisa Ohde, Takehiro Okumura, Haruyasu Murakami, Takehito Shukuya, Hirotsugu Kenmotsu, Tateaki Naito, Yoshikatsu Kanai, Masahiro Endo, Haruhiko Kondo, Takashi Nakajima, Nobuyuki Yamamoto

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH　Vol. 3　No. 5　p. 468-U104　2011　Research paper (scientific journal)

ABCG2 IS A HIGH-CAPACITY URATE TRANSPORTER AND ITS GENETIC IMPAIRMENT INCREASES SERUM URIC ACID LEVELS IN HUMANS

Akiyoshi Nakayama, Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Yuki Ikebuchi, Kousei Ito, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki, Nariyoshi Shinomiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS　Vol. 30　No. 12　p. 1091-1097　2011　Research paper (scientific journal)

IDENTIFICATION OF ABCG2 DYSFUNCTION AS A MAJOR FACTOR CONTRIBUTING TO GOUT

H. Matsuo, T. Takada, K. Ichida, T. Nakamura, A. Nakayama, Y. Takada, C. Okada, Y. Sakurai, T. Hosoya, Y. Kanai, H. Suzuki, N. Shinomiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS　Vol. 30　No. 12　p. 1098-1104　2011　Research paper (scientific journal)

PATHOGENIC GLUT9 MUTATIONS CAUSING RENAL HYPOURICEMIA TYPE 2 (RHUC2)

Y. Kawamura, H. Matsuo, T. Chiba, S. Nagamori, A. Nakayama, H. Inoue, Y. Utsumi, T. Oda, J. Nishiyama, Y. Kanai, N. Shinomiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS　Vol. 30　No. 12　p. 1105-1111　2011　Research paper (scientific journal)

PDZK1により促進されるURAT1とOAT4の巨大分子複合体(A macromolecular complex of URAT1 and OAT4 facilitated by PDZK1)

梅村 康浩, 福富 俊之, 永森 收志, 金井 好克

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　Vol. 83回・33回　p. 3P-0269　2010/12

Receptor for Activated C-Kinase 1 Regulates the Cell Surface Expression and Function of ATP Binding Cassette G2

Yuki Ikebuchi, Kousei Ito, Tappei Takada, Naohiko Anzai, Yoshikatsu Kanai, Hiroshi Suzuki

DRUG METABOLISM AND DISPOSITION　Vol. 38　No. 12　p. 2320-2328　2010/12　Research paper (scientific journal)

Inhibition of L-type Amino Acid Transporter 1 Has Antitumor Activity in Non-small Cell Lung Cancer

Hisao Imai, Kyoichi Kaira, Noboru Oriuchi, Kimihiro Shimizu, Hideyuki Tominaga, Noriko Yanagitani, Noriaki Sunaga, Tamotsu Ishizuka, Shushi Nagamori, Kanyarat Promchan, Takashi Nakajima, Nobuyuki Yamamoto, Masatomo Mori, Yoshikatsu Kanai

ANTICANCER RESEARCH　Vol. 30　No. 12　p. 4819-4828　2010/12　Research paper (scientific journal)

Comparison of L-type amino acid transporter 1 expression and L-[3-F-18]-alpha-methyl tyrosine uptake in outcome of non-small cell lung cancer

Kyoichi Kaira, Noboru Oriuchi, Kimihiro Shimizu, Hisao Imai, Hideyuki Tominaga, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Tetsunari Oyama, Masatomo Mori, Keigo Endo

NUCLEAR MEDICINE AND BIOLOGY　Vol. 37　No. 8　p. 911-916　2010/11　Research paper (scientific journal)

L-type Amino-Acid Transporter 1 Expression Predicts the Response to Preoperative Hyperthermo-Chemoradiotherapy for Advanced Rectal Cancer

Takeshi Ebara, Kyoichi Kaira, Jun-Ichi Saito, Mariko Shioya, Takayuki Asao, Takeo Takahashi, Hideyuki Sakurai, Yoshikatsu Kanai, Hiroyuki Kuwano, Takashi Nakano

ANTICANCER RESEARCH　Vol. 30　No. 10　p. 4223-4227　2010/10　Research paper (scientific journal)

Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in surgically resectable stage III non-small cell lung cancer

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Osamu Kawashima, Yosuke Kamide, Tamotsu Ishizuka, Yoshikatsu Kanai, Takashi Nakajima, Masatomo Mori

EXPERIMENTAL AND THERAPEUTIC MEDICINE　Vol. 1　No. 5　p. 799-808　2010/09　Research paper (scientific journal)

Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo

Akimitsu Maeda, Shuichi Tsuruoka, Kentarou Ushijima, Yoshikatsu Kanai, Hitoshi Endou, Kazuyuki Saito, Etsuko Miyamoto, Akio Fujimura

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 640　No. 1-3　p. 168-171　2010/08　Research paper (scientific journal)

A Novel Transporter of SLC22 Family Specifically Transports Prostaglandins and Co-localizes with 15-Hydroxyprostaglandin Dehydrogenase in Renal Proximal Tubules

Katsuko Shiraya, Taku Hirata, Ryo Hatano, Shushi Nagamori, Pattama Wiriyasermkul, Promsuk Jutabha, Mitsunobu Matsubara, Shigeaki Muto, Hidekazu Tanaka, Shinji Asano, Naohiko Anzai, Hitoshi Endou, Akira Yamada, Hiroyuki Sakurai, Yoshikatsu Kanai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 29　p. 22141-22151　2010/07　Research paper (scientific journal)

Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells

Chun Sung Kim, In-Sung Moon, Ju-Hyun Park, Woo-Cheol Shin, Hong Sung Chun, Sook-Young Lee, Joong-Ki Kook, Heung-Joong Kim, Joo-Cheol Park, Hitoshi Endou, Yoshikatsu Kanai, Byung-Kwon Lee, Do Kyung Kim

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 7　p. 1117-1121　2010/07　Research paper (scientific journal)

Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout

Wako Urano, Atsuo Taniguchi, Naohiko Anzai, Eisuke Inoue, Yoshikatsu Kanai, Mariko Yamanaka, Hitoshi Endou, Naoyuki Kamatani, Hisashi Yamanaka

ANNALS OF THE RHEUMATIC DISEASES　Vol. 69　No. 6　p. 1232-1234　2010/06　Research paper (scientific journal)

Properties of L-Type Amino Acid Transporter 1 in Epidermal Ovarian Cancer

Masahiko Kaji, Maryam Kabir-Salmani, Naohiko Anzai, Chun Ji Jin, Yoshihiro Akimoto, Ayako Horita, Atsuhiko Sakamoto, Yoshikatsu Kanai, Hiroyuki Sakurai, Mitsutoshi Iwashita

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER　Vol. 20　No. 3　p. 329-336　2010/04　Research paper (scientific journal)

腎性低尿酸血症の新規病因遺伝子GLUT9の遺伝子解析

河村 優輔, 松尾 洋孝, 井上 寛規, 内海 由貴, 千葉 俊周, 堂本 英治, 菊池 勇一, 尾田 高志, 西山 純一郎, 櫻井 裕, 金井 好克, 四ノ宮 成祥

防衛衛生　Vol. 57　No. 別冊　p. 98-98　2010/01

L-type Amino-acid Transporter 1 Expression Predicts the Response to Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer

T. Ebara, K. Kaira, M. Shioya, T. Asao, T. Takahashi, H. Sakurai, Y. Kanai, H. Kuwano, T. Nakano

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS　Vol. 78　No. 3　p. S330-S331　2010　Research paper (scientific journal)

A pathogenic C-terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7

Tomohiro Numata, Shigeki Kiyonaka, Yoshikatsu Kanai, Yasuo Mori

JOURNAL OF PHYSIOLOGICAL SCIENCES　Vol. 60　2010　Research paper (scientific journal)

Pathogenic C-terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7

Shigeki Kiyonaka, Kyoko Miyagi, Kazunori Yamada, Takafumi Miki, Emiko Mori, Kenta Kato, Tomohiro Numata, Yuichi Sawaguchi, Toru Kimura, Yoshikatsu Kanai, Yasuo Mori

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 112　p. 202P-202P　2010　Research paper (scientific journal)

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

Koji Oda, Noriko Hosoda, Hiroshi Endo, Kunio Saito, Kenji Tsujihara, Michio Yamamura, Takeshi Sakata, Naohiko Anzai, Michael F. Wempe, Yoshikatsu Kanai, Hitoshi Endou

CANCER SCIENCE　Vol. 101　No. 1　p. 173-179　2010/01　Research paper (scientific journal)

CD98 Expression Is Associated with Poor Prognosis in Resected Non-Small-Cell Lung Cancer with Lymph Node Metastases

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Osamu Kawashima, Yosuke Kamide, Tamotsu Ishizuka, Yoshikatsu Kanai, Takashi Nakajima, Masatomo Mori

ANNALS OF SURGICAL ONCOLOGY　Vol. 16　No. 12　p. 3473-3481　2009/12　Research paper (scientific journal)

A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7

Kyoko Miyagi, Shigeki Kiyonaka, Kazunori Yamada, Takafumi Miki, Emiko Mori, Kenta Kato, Tomohiro Numata, Yuichi Sawaguchi, Takuro Numaga, Toru Kimura, Yoshikatsu Kanai, Mitsuhiro Kawano, Minoru Wakamori, Hideki Nomura, Ichiro Koni, Masakazu Yamagishi, Yasuo Mori

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 49　p. 34400-34412　2009/12　Research paper (scientific journal)

Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4

Yuki Ikebuchi, Tappei Takada, Kousei Ito, Takashi Yoshikado, Naohiko Anzai, Yoshikatsu Kanai, Hiroshi Suzuki

HEPATOLOGY RESEARCH　Vol. 39　No. 11　p. 1091-1107　2009/11　Research paper (scientific journal)

F-18-FMT Uptake Seen Within Primary Cancer on PET Helps Predict Outcome of Non-Small Cell Lung Cancer

Kyoichi Kaira, Noboru Oriuchi, Kimihiro Shimizu, Hideyuki Tominaga, Noriko Yanagitani, Noriaki Sunaga, Tamotsu Ishizuka, Yoshikatsu Kanai, Masatomo Mori, Keigo Endo

JOURNAL OF NUCLEAR MEDICINE　Vol. 50　No. 11　p. 1770-1776　2009/11　Research paper (scientific journal)

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Akiyoshi Nakayama, Yuki Ikebuchi, Kousei Ito, Yasuyoshi Kusanagi, Toshinori Chiba, Shin Tadokoro, Yuzo Takada, Yuji Oikawa, Hiroki Inoue, Koji Suzuki, Rieko Okada, Junichiro Nishiyama, Hideharu Domoto, Satoru Watanabe, Masanori Fujita, Yuji Morimoto, Mariko Naito, Kazuko Nishio, Asahi Hishida, Kenji Wakai, Yatami Asai, Kazuki Niwa, Keiko Kamakura, Shigeaki Nonoyama, Yutaka Sakurai, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki, Nobuyuki Hamajima, Nariyoshi Shinomiya

SCIENCE TRANSLATIONAL MEDICINE　Vol. 1　No. 5　2009/11　Research paper (scientific journal)

Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Takashi Nakajima, Masatomo Mori

LUNG CANCER　Vol. 66　No. 1　p. 120-126　2009/10　Research paper (scientific journal)

腎性低尿酸血症の新規病因遺伝子glucose transporter 9(GLUT9)の同定

松尾 洋孝, 中山 昌喜, 金井 好克, 四ノ宮 成祥

痛風と核酸代謝　Vol. 33　No. 1　p. 77-77　2009/07

Amino acid transporter LAT3 is required for podocyte development and function

Yuji Sekine, Yukino Nishibori, Yoshihiro Akimoto, Akihiko Kudo, Noriko Ito, Daisuke Fukuhara, Ryota Kurayama, Eiji Higashihara, Ellappan Babu, Yoshikatsu Kanai, Katsuhiko Asanuma, Michio Nagata, Årindam Majumdar, Karl Tryggvason, Kunimasa Yan

Journal of the American Society of Nephrology　Vol. 20　No. 7　p. 1586-1596　2009/07　Research paper (scientific journal)

Amino Acid Transporter LAT3 Is Required for Podocyte Development and Function

Yuji Sekine, Yukino Nishibori, Yoshihiro Akimoto, Akihiko Kudo, Noriko Ito, Daisuke Fukuhara, Ryota Kurayama, Eiji Higashihara, Ellappan Babu, Yoshikatsu Kanai, Katsuhiko Asanuma, Michio Nagata, Arindam Majumdar, Karl Tryggvason, Kunimasa Yan

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　Vol. 20　No. 7　p. 1586-1596　2009/07　Research paper (scientific journal)

L-Type Amino Acid Transporter 1 (LAT1) Is Frequently Expressed in Thymic Carcinomas but Is Absent in Thymomas

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

JOURNAL OF SURGICAL ONCOLOGY　Vol. 99　No. 7　p. 433-438　2009/06　Research paper (scientific journal)

L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer

Hisao Imai, Kyoichi Kaira, Noboru Oriuchi, Noriko Yanagitani, Noriaki Sunaga, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

HISTOPATHOLOGY　Vol. 54　No. 7　p. 804-813　2009/06　Research paper (scientific journal)

腎性低尿酸血症の第2の病因遺伝子GLUT9の同定

北村 陽典, 松尾 洋孝, 千葉 俊周, 永森 收志, 中山 昌喜, 堂本 英治, Phetdee Kanokporn, Wiriyasermkul Pattama, 菊池 勇一, 尾田 高志, 西山 純一郎, 守本 祐司, 金井 好克, 四ノ宮 成祥

日本腎臓学会誌　Vol. 51　No. 3　p. 309-309　2009/04

System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line

Kohichi Yamauchi, Hiroyuki Sakurai, Toru Kimura, Pattama Wiriyasermkul, Shushi Nagamori, Yoshikatsu Kanai, Naoyuki Kohno

CANCER LETTERS　Vol. 276　No. 1　p. 95-101　2009/04　Research paper (scientific journal)

Correlation of angiogenesis with F-18-FMT and F-18-FDG uptake in non-small cell lung cancer

Kyoichi Kaira, Noboru Oriuchi, Kimihiro Shimizu, Tomohiro Ishikita, Tetsuya Higuchi, Hisao Imai, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Keigo Endo, Masatomo Mori

CANCER SCIENCE　Vol. 100　No. 4　p. 753-758　2009/04　Research paper (scientific journal)

Evaluation of thoracic tumors with F-18-FMT and F-18-FDG PET-CT: A clinicopathological study

Kyoichi Kaira, Noboru Oriuchi, Kimihiro Shimizu, Tomohiro Ishikita, Tetsuya Higuchi, Hisao Imai, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Keigo Endo, Masatomo Mori

INTERNATIONAL JOURNAL OF CANCER　Vol. 124　No. 5　p. 1152-1160　2009/03　Research paper (scientific journal)

腎性低尿酸血症の新規病因遺伝子glucose transporter 9(GLUT9)の同定

松尾 洋孝, 中山 昌喜, 金井 好克, 四ノ宮 成祥

日本痛風・核酸代謝学会総会プログラム抄録集　Vol. 42回　p. 58-58　2009/02

Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

CANCER SCIENCE　Vol. 100　No. 2　p. 249-254　2009/02　Research paper (scientific journal)

Posttranslational regulation of Abcc2 expression by SUMOylation system

Satoko Minami, Kousei Ito, Masashi Honma, Yuki Ikebuchi, Naohiko Anzai, Yoshikatsu Kanai, Tamotsu Nishida, Sachiko Tsukita, Shuichi Sekine, Toshiharu Horie, Hiroshi Suzuki

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 296　No. 2　p. G406-G413　2009/02　Research paper (scientific journal)

腎性低尿酸血症の新規病因遺伝子GLUT9の同定

草薙 恭圭, 松尾 洋孝, 千葉 俊周, 中山 昌喜, 堂本 英治, 菊池 勇一, 尾田 高志, 西山 純一郎, 守本 祐司, 鎌倉 恵子, 野々山 恵章, 金井 好克, 四ノ宮 成祥

防衛衛生　Vol. 56　No. 別冊　p. 84-84　2009/01

A novel role of the C-terminus of b(0,+)AT in the ER-Golgi trafficking of the rBAT-b(0,+)AT heterodimeric amino acid transporter

Shinichi Sakamoto, Arthit Chairoungdua, Shushi Nagamori, Pattama Wiriyasermkul, Kanyarat Promchan, Hidekazu Tanaka, Toru Kimura, Takeshi Ueda, Masaaki Fujimura, Yasuhiro Shigeta, Yukio Naya, Koichiro Akakura, Haruo Ito, Hitoshi Endou, Tomohiko Ichikawa, Yoshikatsu Kanai

BIOCHEMICAL JOURNAL　Vol. 417　No. 2　p. 441-448　2009/01　Research paper (scientific journal)

L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer

Takeshi Sakata, Golam Ferdous, Tomoko Tsuruta, Takefumi Satoh, Shiro Baba, Tomoko Muto, Akinori Ueno, Yoshikatsu Kanai, Hitoshi Endou, Isao Okayasu

PATHOLOGY INTERNATIONAL　Vol. 59　No. 1　p. 7-18　2009/01　Research paper (scientific journal)

Significance of System L Amino Acid Transporter 1 (LAT-1) and 4F2 Heavy Chain (4F2hc) Expression in Human Developing Intestines

Chikara Ohno, Yohko Nakanishi, Taku Honma, Akihiro Henmi, Masahiko Sugitani, Yoshikatsu Kanai, Norimichi Nemoto

ACTA HISTOCHEMICA ET CYTOCHEMICA　Vol. 42　No. 3　p. 73-81　2009　Research paper (scientific journal)

Regulation of placental amino acid transporter activity by mammalian target of rapamycin

S. Roos, Y. Kanai, P. D. Prasad, T. L. Powell, T. Jansson

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY　Vol. 296　No. 1　p. C142-C150　2009/01　Research paper (scientific journal)

l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Shigebumi Tanaka, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

CANCER SCIENCE　Vol. 99　No. 12　p. 2380-2386　2008/12　Research paper (scientific journal)

Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia

Hirotaka Matsuo, Toshinori Chiba, Shushi Nagamori, Akiyoshi Nakayama, Hideharu Domoto, Kanokporn Phetdee, Pattama Wiriyasermkul, Yuichi Kikuchi, Takashi Oda, Junichiro Nishiyama, Takahiro Nakamura, Yuji Morimoto, Keiko Kamakura, Yutaka Sakurai, Shigeaki Nonoyama, Yoshikatsu Kanai, Nariyoshi Shinomiya

AMERICAN JOURNAL OF HUMAN GENETICS　Vol. 83　No. 6　p. 744-751　2008/12　Research paper (scientific journal)

Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human L-Type Amino Acid Transporters

Emiko Morimoto, Yoshikatsu Kanai, Do Kyung Kim, Arthit Chairoungdua, Hye Won Choi, Michael F. Wempe, Naohiko Anzai, Hitoshl Endou

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 108　No. 4　p. 505-516　2008/12　Research paper (scientific journal)

L-Glutamate Enhances Methylmercury Toxicity by Synergistically Increasing Oxidative Stress

Sirirat Amonpatumrat, Hiroyuki Sakurai, Pattama Wiriyasermkul, Narakorn Khunweeraphong, Shushi Nagamori, Hidekazu Tanaka, Pawinee Piyachaturawat, Yoshikatsu Kanai

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 108　No. 3　p. 280-289　2008/11　Research paper (scientific journal)

Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells

Akimitsu Maeda, Shuichi Tsuruoka, Yoshikatsu Kanai, Hitoshi Endou, Kazuyuki Saito, Etsuko Miyamoto, Akio Fujimura

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 596　No. 1-3　p. 166-172　2008/10　Research paper (scientific journal)

Characterization of Amino Acid Transport System L in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells

No-Seung Park, Su-Gwan Kim, Hak-Kyun Kim, Seong-Yong Moon, Chun Sung Kim, Seon-Ho Cho, Yoshikatsu Kanai, Hitoshi Endou, Do Kyung Kim

ANTICANCER RESEARCH　Vol. 28　No. 5A　p. 2649-2655　2008/09　Research paper (scientific journal)

Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid

Hatsuki Nakagawa, Taku Hirata, Tomohiro Terada, Promsuk Jutabha, Daisaku Miura, Kouji H. Harada, Kayoko Inoue, Naohiko Anzai, Hitoshi Endou, Ken-ichi Inui, Yoshikatsu Kanai, Akio Koizumi

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY　Vol. 103　No. 1　p. 1-8　2008/07　Research paper (scientific journal)

BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells

Chun Sung Kim, Seon-Ho Cho, Hong Sung Chun, Sook-Young Lee, Hitoshi Endou, Yoshikatsu Kanai, Do Kyung Kim

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 31　No. 6　p. 1096-1100　2008/06　Research paper (scientific journal)

[Molecular mechanisms of urate transport in renal tubules: localization and function of urate transporters].

Kanai Y

Nihon rinsho. Japanese journal of clinical medicine　Vol. 66　No. 4　p. 659-666　2008/04

The membrane-spanning domain of CD98 heavy chain promotes α<inf>v</inf>β<inf>3</inf> integrin signals in human extravillous trophoblasts

Maryam Kabir-Salmani, Michiko N. Fukuda, Masami Kanai-Azuma, Nesar Ahmed, Shigetatsu Shiokawa, Yoshihiro Akimoto, Keiji Sakai, Seishi Nagamori, Yoshikatsu Kanai, Kazuhiro Sugihara, Mitsutoshi Iwashita

Molecular Endocrinology　Vol. 22　No. 3　p. 707-715　2008/03　Research paper (scientific journal)

Differential expression of system L amino acid transporters during wound healing process in the skin of young and old rats

Moon-Jin Jeong, Chun Sung Kim, Joo-Cheol Park, Heung-Joong Kim, Yeong Mu Ko, Kyung Jin Park, Soon-Jeong Jeong, Hitoshi Endou, Yoshikatsu Kanai, Do-Seon Lim, Do Kyung Kim

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 31　No. 3　p. 395-399　2008/03　Research paper (scientific journal)

Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate

Rafiqul Islam, Naohiko Anzai, Nesar Ahmed, Babu Ellapan, Chun Ji Jin, Sunena Srivastava, Daisaku Miura, Toshiyuki Fukutomi, Yoshikatsu Kanai, Hitoshi Endou

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　No. 3　p. 525-528　2008/03　Research paper (scientific journal)

Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells

Keiichi Kobayashi, Akiko Ohnishi, Jutabha Promsuk, Saki Shimizu, Yoshikatsu Kanai, Yoshiaki Shiokawa, Motoo Nagane

NEUROSURGERY　Vol. 62　No. 2　p. 493-503　2008/02　Research paper (scientific journal)

Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer

K. Kaira, N. Oriuchi, H. Imai, K. Shimizu, N. Yanagitani, N. Sunaga, T. Hisada, S. Tanaka, T. Ishizuka, Y. Kanai, H. Endou, T. Nakajima, M. Mori

BRITISH JOURNAL OF CANCER　Vol. 98　No. 4　p. 742-748　2008/02　Research paper (scientific journal)

APP-015 アミノ酸トランスポーターLAT1発現による前立腺がんの新しい予後予測因子の検討(前立腺癌/診断・マーカー・統計,総会賞応募ポスター,第96回日本泌尿器科学会総会)

坂田 武, フェルダス ゴラム, 佐藤 威文, 武藤 朋子, 馬場 志郎, 金井 好克, 岡安 勲, 遠藤 仁

日本泌尿器科学会雑誌　Vol. 99　No. 2　p. 217-217　2008

[Topics in renal physiology: transgenic animals and cellular signaling].

Kanai Y

Nihon Jinzo Gakkai shi　Vol. 50　No. 1　p. 1-4　2008

Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Osamu Kawashima, Hironobu Iijima, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

PATHOLOGY RESEARCH AND PRACTICE　Vol. 204　No. 8　p. 553-561　2008　Research paper (scientific journal)

Functional and immunochemical characterization of a novel organic anion transporter oat8 (Slc22a9) in rat renal collecting duct

Hirokazu Yokoyama, Naohiko Anzai, Marija Ljubojevic, Naoko Ohtsu, Takeshi Sakata, Hiroki Miyazaki, Hiroshi Nonoguchi, Rafiqul Islam, Maristella Lika Onozato, Akihiro Tojo, Kimio Tomita, Yoshikatsu Kanai, Takashi Igarashi, Ivan Sabolic, Hitoshi Endou

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY　Vol. 21　No. 4　p. 269-278　2008　Research paper (scientific journal)

Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: A clinicopathologic study

Kyoichi Kaira, Noboru Oriuchi, Yoshimi Otani, Kimihiro Shimizu, Shigebumi Tanaka, Hisao Imai, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Kunio Dobashi, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Keigo Endo, Masatomo Mori

CLINICAL CANCER RESEARCH　Vol. 13　No. 21　p. 6369-6378　2007/11　Research paper (scientific journal)

Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract

Kuniaki Nakanishi, Sho Ogata, Hirotaka Matsuo, Yoshikatsu Kanai, Hitoshi Endou, Sadayuki Hiroi, Susumu Tominaga, Shinsuke Aida, Hiroyasu Kasamatsu, Toshiaki Kawai

VIRCHOWS ARCHIV　Vol. 451　No. 3　p. 681-690　2007/09　Research paper (scientific journal)

Spermatogenesis in aged rats after prenatal 3,3',4,4',5-pentachlorobiphenyl exposure

Shin Wakui, Fumio Takagi, Tomoko Muto, Kiyofumi Yokoo, Shyou Hirono, Yasuko Kobayashi, Kinji Shirota, Fumiaki Akahori, Yoshihiko Suzuki, Hiroshi Hano, Hitoshi Endou, Yoshikatsu Kanai

TOXICOLOGY　Vol. 238　No. 2-3　p. 186-191　2007/09　Research paper (scientific journal)

Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate

Ho Jung Shin, Naohiko Anzai, Atsushi Enomoto, Xin He, Do Kyung Kim, Hitoshi Endou, Yoshikatsu Kanai

HEPATOLOGY　Vol. 45　No. 4　p. 1046-1055　2007/04　Research paper (scientific journal)

Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter, LAT1

Shadi Baniasadi, Arthit Chairoungdua, Yuji Iribe, Yoshikatsu Kanai, Hitoshi Endou, Ken-ichi Aisaki, Katsuhide Igarashi, Jun Kanno

ARCHIVES OF PHARMACAL RESEARCH　Vol. 30　No. 4　p. 444-452　2007/04　Research paper (scientific journal)

New insights into renal transport of urate

Naohiko Anzai, Yoshikatsu Kanai, Hitoshi Endou

CURRENT OPINION IN RHEUMATOLOGY　Vol. 19　No. 2　p. 151-157　2007/03

Protein characterization of Na+-independent system L amino acid transporter 3 in mice - A potential role in supply of branched-chain amino acids under nutrient starvation

Daisuke Fukuhara, Yoshikatsu Kanai, Arthit Chairoungdua, Ellappan Babu, Fumio Bessho, Toshio Kawano, Yoshihiro Akimoto, Hitoshi Endou, Kunimasa Yan

AMERICAN JOURNAL OF PATHOLOGY　Vol. 170　No. 3　p. 888-898　2007/03　Research paper (scientific journal)

L-type amino acid transporter-1 expressed in human astrocytomas, U343MGa

Shinji Asano, Megumi Kameyama, Ayako Oura, Anna Morisato, Hideki Sakai, Yoshiaki Tabuchi, Arthit Chairoungdua, Hitoshi Endou, Yoshikatsu Kanai

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 30　No. 3　p. 415-422　2007/03　Research paper (scientific journal)

Characterization of Human Orgnic Anion Transporter 4 (hOAT4) as a Low Affinity p-aminohippurate (PAH) Transporter

ISLAM Rafiqul, ANZAI Naohiko, EKARATANAWONG Sophapun, KUNDU-SRIVASTAVA Sunena, Ji JIN Chun, NOSHIRO-KOFUJI Rie, MIYAO Kazuhiro, YAMANISHI Ai, FUKUTOMI Toshiyuki, KANAI Yoshikatsu, ENDOU Hitoshi

JOURNAL OF THE KYORIN MEDICAL SOCIETY　Vol. 38　No. 2　p. 61-68　2007

Metabolomic analysis of the knockout mice of a novel organic anion transporter OATN1: evaluation of the function and the potential roles as a therapeutic target

Xin He, Taku Hirata, Babu Ellappan, Naohiko Anzai, Takamasa Ishikawa, Tomoyoshi Soga, Hitoshi Entou, Yoshikatsu Kanai

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 103　No. Supplement 1　p. 51P-51P　2007　Research paper (scientific journal)

Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E-2 transport pathway

Sirinun Nilwarangkoon, Naohiko Anzai, Katsuko Shiraya, Erkang Yu, Rafiqul Islam, Seok Ho Cha, Maristela Lika Onozato, Daisaku Miura, Promsuk Jutabha, Akihiro Tojo, Yoshikatsu Kanai, Hitoshi Endou

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 103　No. 1　p. 48-55　2007/01　Research paper (scientific journal)

Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis

Shin Wakui, Kiyofumi Yokoo, Tomoko Muto, Yoshihiko Suzuki, Hiroyuki Takahashi, Masakuni Furusato, Hiroshi Hano, Hitoshi Endou, Yoshikatsu Kanai

LABORATORY INVESTIGATION　Vol. 86　No. 11　p. 1172-1184　2006/11　Research paper (scientific journal)

Expression of amino acid transporter LATI and 4F2hc in the healing process after the implantation of a tooth ash and plaster of Paris mixture

Su-Gwan Kim, Young-Chae Ahn, Jung-Hoon Yoon, Hak-Kyun Kim, Sun-Sik Park, Sang-Gun Ahn, Hitoshi Endou, Yoshikatsu Kanai, Joo-Cheol Park, Do Kyung Kim

IN VIVO　Vol. 20　No. 5　p. 591-597　2006/09　Research paper (scientific journal)

L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors

H Nawashiro, N Otani, N Shinomiya, S Fukui, H Ooigawa, K Shima, H Matsuo, Y Kanai, H Endou

INTERNATIONAL JOURNAL OF CANCER　Vol. 119　No. 3　p. 484-492　2006/08　Research paper (scientific journal)

Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3

Anabel Brandoni, Naohiko Anzai, Yoshikatsu Kanai, Hitoshi Endou, Adriana Monica Torres

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE　Vol. 1762　No. 7　p. 673-682　2006/07　Research paper (scientific journal)

Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3.

Brandoni A, Anzai N, Kanai Y, Endou H, Torres AM

Biochimica et biophysica acta　Vol. 1762　No. 7　p. 673-682　2006/07

The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells

Chang-Hyun Kim, Kyung Jin Park, Jung Rim Park, Yoshikatsu Kanai, Hitoshi Endou, Joo-Cheol Park, Do Kyung Kim

ANTICANCER RESEARCH　Vol. 26　No. 4B　p. 2943-2948　2006/07　Research paper (scientific journal)

The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity

R. Noshiro, N. Anzai, T. Sakata, H. Miyazaki, T. Terada, H. J. Shin, X. He, D. Miura, K. Inui, Y. Kanai, H. Endou

KIDNEY INTERNATIONAL　Vol. 70　No. 2　p. 275-282　2006/07　Research paper (scientific journal)

Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells

SG Kim, HH Kim, HK Kim, CH Kim, HS Chun, Y Kanai, H Endou, DK Kim

ANTICANCER RESEARCH　Vol. 26　No. 3A　p. 1989-1996　2006/05　Research paper (scientific journal)

A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter

Y Shigeta, Y Kanai, A Chairoungdua, N Ahmed, S Sakamoto, H Matsuo, DK Kim, M Fujimura, N Anzai, K Mizoguchi, T Ueda, K Akakura, T Ichikawa, H Ito, H Endou

KIDNEY INTERNATIONAL　Vol. 69　No. 7　p. 1198-1206　2006/04　Research paper (scientific journal)

Prenatal 3,3 ',4,4 ',5-pentachlorobiphenyl exposure modulates induction of rat hepatic CYP 1A1, 1B1, and AhR by 7,12-dimethylbenz[a]anthracene

S Wakui, K Yokoo, H Takahashi, T Muto, Y Suzuki, Y Kanai, H Hano, M Furusato, H Endou

TOXICOLOGY AND APPLIED PHARMACOLOGY　Vol. 210　No. 3　p. 200-211　2006/02　Research paper (scientific journal)

LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung

K Nakanishi, H Matsuo, Y Kanai, H Endou, S Hiroi, S Tominaga, M Mukai, E Ikeda, Y Ozeki, S Aida, T Kawai

VIRCHOWS ARCHIV　Vol. 448　No. 2　p. 142-150　2006/02　Research paper (scientific journal)

[Molecular mechanism in biological transport in the kidney: Organic cation/anion transporters].

Kanai Y

Nihon rinsho. Japanese journal of clinical medicine　Vol. 64 Suppl 2　p. 169-175　2006/02

C-9 塩基性アミノ酸トランスポーターの線虫オルソログの同定とその機能解析(一般口演,第34回杏林医学会総会)

平田 拓, 金井 好克

杏林医学会雑誌　Vol. 37　No. 1　p. 32-33　2006

D-4 上皮型アミノ酸輸送体B^0を介するメチル水銀の輸送についての検討(一般口演,第35回杏林医学会総会)

Islam Rafiqul, 何 新, 安西 尚彦, 金井 好克

杏林医学会雑誌　Vol. 37　No. 3　p. 74-74　2006

D-5 アミノ酸トランスポーターLAT1ノックアウトマウスの解析(一般口演,第35回杏林医学会総会)

Li Yuewei, 金井 正美, 川上 速人, 金井 好克

杏林医学会雑誌　Vol. 37　No. 3　p. 75-75　2006

D-2 メタボローム技術を用いた新しいサブファミリーに属する新規有機イオントランスポーターの生理機能の解析(一般口演,第35回杏林医学会総会)

平田 拓, 何 新, 安西 尚彦, 金井 好克

杏林医学会雑誌　Vol. 37　No. 3　p. 74-74　2006

腎尿細管管腔側プロスタグランジン・シグナル機構を構成する輸送分子複合体の解明(平成18年度杏林大学医学部研究奨励賞中間発表,第35回杏林医学会総会)

安西 尚彦, 金井 好克

杏林医学会雑誌　Vol. 37　No. 3　p. 79-80　2006

D-3 FRET現象を用いたPDZK1 : 膜輸送分子複合体の解明(一般口演,第35回杏林医学会総会)

福冨 俊之, 安西 尚彦, 上野 剛, 木村 徹, 金井 好克

杏林医学会雑誌　Vol. 37　No. 3　p. 74-74　2006

Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area

K Tsuji, K Yamauchi, M Yang, P Jiang, M Bouvet, H Endo, Y Kanai, K Yamashita, AR Moossa, RM Hoffman

CANCER RESEARCH　Vol. 66　No. 1　p. 303-306　2006/01　Research paper (scientific journal)

Organic anion transporter family: Current knowledge

N Anzai, Y Kanai, H Endou

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 100　No. 5　p. 411-426　2006

Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins

H Miyazaki, N Anzai, S Ekaratanawong, T Sakata, HJ Shin, P Jutabha, T Hirata, He, X, H Nonoguchi, K Tomita, Y Kanai, H Endou

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　Vol. 16　No. 12　p. 3498-3506　2005/12　Research paper (scientific journal)

High expression of L-type amino acid transporter 1 in infiltrating glioma cells

Hiroshi Nawashiro, Naoki Otani, Youichi Uozumi, Hidetoshi Ooigawa, Terushige Toyooka, Takamoto Suzuki, Hiroshi Katoh, Nobusuke Tsuzuki, Akira Ohnuki, Katsuji Shima, Nariyoshi Shinomiya, Hirotaka Matsuo, Yoshikatsu Kanai

Brain Tumor Pathology　Vol. 22　No. 2　p. 89-91　2005/12　Research paper (scientific journal)

Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules

N Anzai, P Jutabha, A Enomoto, H Yokoyama, H Nonoguchi, T Hirata, K Shiraya, He, X, SH Cha, M Takeda, H Miyazaki, T Sakata, K Tomita, T Igarashi, Y Kanai, N Anzai

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 315　No. 2　p. 534-544　2005/11　Research paper (scientific journal)

Integrated physiology of proximal tubular organic anion transport

N Anzai, P Jutabha, Y Kanai, H Endou

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION　Vol. 14　No. 5　p. 472-479　2005/09

CYP1 and AhR expression in 7,12-dimethylbenz[a] anthracene-induced mammary carcinoma of rats prenatally exposed to 3,3,4,4 ',5-pentachlorobiphenyl

S Wakui, K Yokoo, H Takahashi, T Muto, Y Suzuki, Y Kanai, H Hano, M Furusato, H Endou

TOXICOLOGY　Vol. 211　No. 3　p. 231-241　2005/08　Research paper (scientific journal)

Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells

JH Yoon, IJ Kim, F Kim, HJ Kim, MJ Jeong, SG Ahn, SA Kim, CH Lee, BK Choi, JK Kim, KY Jung, S Lee, Y Kanai, H Endou, DK Kim

CANCER LETTERS　Vol. 222　No. 2　p. 237-245　2005/05　Research paper (scientific journal)

神経膠腫のアミノ酸トランスポーターLAT1の発現から見た腫瘍と正常脳の境界

苗代 弘, 大谷 直樹, 島 克司, 四ノ宮 成祥, 松尾 洋孝, 金井 好克

Brain Tumor Pathology　Vol. 22　No. Suppl.　p. 57-57　2005/04

Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule

SY Park, JK Kim, IJ Kim, BK Choi, KY Jung, S Lee, KJ Park, A Chairoungdua, Y Kanai, H Endou, DK Kim

ARCHIVES OF PHARMACAL RESEARCH　Vol. 28　No. 4　p. 421-432　2005/04　Research paper (scientific journal)

C-17 PDZドメインタンパク質PDZK1による尿酸トランスポーターURAT1輸送機能制御(第13回杏林医学会総会)

安西 尚彦, Shin Ho Jung, 土岐 昭依, 平田 拓, Arthit Chairoungdua, 金井 好克

杏林医学会雑誌　Vol. 36　No. 1　p. 97-97　2005

C-13 新規肝特異的有機アニオントランスポーターOAT7の同定 : 細胞内有機アニオンによる輸送機能への影響(第13回杏林医学会総会)

Shin Ho Jung, 安西 尚彦, 金井 好克

杏林医学会雑誌　Vol. 36　No. 1　p. 97-97　2005

System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells

DK Kim, IJ Kim, S Hwang, JH Kook, MC Lee, BA Shin, CS Bae, JH Yoon, SG Ahn, SA Kim, Y Kanai, H Endou, JK Kim

NEUROSCIENCE RESEARCH　Vol. 50　No. 4　p. 437-446　2004/12　Research paper (scientific journal)

The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus

N Anzai, H Miyazaki, R Noshiro, S Khamdang, A Chairoungdua, HJ Shin, A Enomoto, S Sakamoto, T Hirata, K Tomita, Y Kanai, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 44　p. 45942-45950　2004/10　Research paper (scientific journal)

Mutations in SLC6A19, encoding B(0)AT1, cause Hartnup disorder

R Kleta, E Romeo, Z Ristic, T Ohura, C Stuart, M Arcos-Burgos, MH Dave, CA Wagner, SRM Camargo, S Inoue, N Matsuura, A Helip-Wooley, D Bockenhauer, R Warth, Bernardini, I, G Visser, T Eggermann, P Lee, A Chairoungdua, P Jutabha, E Babu, S Nilwarangkoon, N Anzai, Y Kanai, F Verrey, WA Gahl, A Koizumi

NATURE GENETICS　Vol. 36　No. 9　p. 999-1002　2004/09　Research paper (scientific journal)

Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2

W Takabe, Y Kanai, A Chairoungdua, N Shibata, S Toi, M Kobayashi, T Kodama, N Noguchi

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 24　No. 9　p. 1640-1645　2004/09　Research paper (scientific journal)

Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes

A Nishida, H Iwata, Y Kudo, T Kobayashi, Y Matsuoka, Y Kanai, H Endou

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 27　No. 6　p. 817-820　2004/06　Research paper (scientific journal)

Measurement of glutamate uptake and reversed transport by rat synaptosome transporters

A Nishida, H Iwata, Y Kudo, T Kobayashi, Y Matsuoka, Y Kanai, H Endou

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 27　No. 6　p. 813-816　2004/06　Research paper (scientific journal)

Expression of L-type amino acid transporter1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions

DK Kim, SG Ahn, JC Park, Y Kanai, H Endou, JH Yoon

ANTICANCER RESEARCH　Vol. 24　No. 3A　p. 1671-1675　2004/05　Research paper (scientific journal)

Preferential expression of L-type amino acid transporter 1 in ameloblasts during rat tooth development

JC Park, YB Kim, JH Yoon, HJ Kim, SM Kim, Y Kanai, H Endou, DK Kim

ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C　Vol. 33　No. 2　p. 119-124　2004/04　Research paper (scientific journal)

Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules

S Ekaratanawong, N Anzai, P Jutabha, H Miyazaki, R Noshiro, M Takeda, Y Kanai, S Sophasan, H Endou

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 94　No. 3　p. 297-304　2004/03　Research paper (scientific journal)

Expression and functional dcharacterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells

JH Yoon, YB Kim, MS Kim, JC Park, JK Kook, HM Jung, SG Kim, H Yoo, YM Ko, SH Lee, BY Kim, HS Chun, Y Kanai, H Endou, DK Kim

CANCER LETTERS　Vol. 205　No. 2　p. 215-226　2004/03　Research paper (scientific journal)

High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices

H Matsuo, Y Kanai, M Tokunaga, T Nakata, A Chairoungdua, H Ishimine, S Tsukada, H Ooigawa, H Nawashiro, Y Kobayashi, J Fukuda, H Endou

NEUROSCIENCE LETTERS　Vol. 358　No. 2　p. 123-126　2004/03　Research paper (scientific journal)

The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects

Y Kanai, MA Hediger

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　Vol. 447　No. 5　p. 469-479　2004/02　Research paper (scientific journal)

The ancillary proteins of HATs: SLC3 family of amino acid transporters

M Palacin, Y Kanai

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　Vol. 447　No. 5　p. 490-494　2004/02　Research paper (scientific journal)

CATs and HATs: the SLC7 family of amino acid transporters

F Verrey, EI Closs, CA Wagner, M Palacin, H Endou, Y Kanai

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY　Vol. 447　No. 5　p. 532-542　2004/02　Research paper (scientific journal)

C-17 ラット腎近位尿細管管腔側膜に発現する新規硫酸抱合体トランスポーターの同定(一般口演)(第32回杏林医学会総会)

平田 拓, 安西 尚彦, Jutabha Promsuk, 横山 宏和, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 35　No. 1　p. 136-137　2004

C-16 ラット腎に発現する新規有機イオントランスポーターOAT8の同定(一般口演)(第32回杏林医学会総会)

横山 宏和, 安西 尚彦, 平田 拓, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 35　No. 1　p. 136-136　2004

C-18 新規塩基性アミノ酸トランスポーターの同定と機能解析(一般口演)(第32回杏林医学会総会)

Li Yuewei, Chairougdua Arthit, 入部 雄司, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 35　No. 1　p. 137-137　2004

C-20 乳癌組織におけるアミノ酸トランスポーター発現に関する免疫組織化学的検討(一般口演)(第32回杏林医学会総会)

黒田 琢磨, 寺岡 秀郎, 小林 ゆかり, 金井 好克, 遠藤 仁, 呉屋 朝幸, 寺戸 雄一

杏林医学会雑誌　Vol. 35　No. 1　p. 137-138　2004

2SB03 Mechanisms of apical and basolateral sorting of heterodimeric amino acid transporters

Kanai Y.

Seibutsu Butsuri　Vol. 44　2004

S13-5 Significance of LAT1/4F2hc complex in the progression of clear cell renal cell carcinoma

Igarashi Tatsuo, Ahmed Nesar, Kanai Yoshikatsu, Ito Haruo

The Japanese Journal of Urology　Vol. 95　No. 2　p. 227-227　2004

Urate transporter: its regulation and clinical relevance

Y Kanai, N Anzai, M Hosoyamada, H Endou

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 124　p. 25-28　2004　Research paper (scientific journal)

Transport of Tc-99m-MAG3 via rat renal organic anion transporter 1

N Shikano, Y Kanai, K Kawai, N Ishikawa, H Endou

JOURNAL OF NUCLEAR MEDICINE　Vol. 45　No. 1　p. 80-85　2004/01　Research paper (scientific journal)

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

T Sakata, N Anzai, HJ Shin, R Noshiro, T Hirata, H Yokoyama, Y Kanai, H Endou

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 313　No. 3　p. 789-793　2004/01　Research paper (scientific journal)

The glutamate and neutral amino acid transporter family: physiological and pharmacological implications

Y Kanai, MA Hediger

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 479　No. 1-3　p. 237-247　2003/10　Research paper (scientific journal)

Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters

E Babu, Y Kanai, A Chairoungdua, DK Kim, Y Iribe, S Tangtrongsup, P Jutabha, YW Li, N Ahmed, S Sakamoto, N Anzai, S Nagamori, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 44　p. 43838-43845　2003/10　Research paper (scientific journal)

[Urate transporter and renal hypouricemia].

Enomoto A, Niwa T, Kanai Y, Endou H

Rinsho byori. The Japanese journal of clinical pathology　Vol. 51　No. 9　p. 892-897　2003/09

Sequential increases in 4F2hc expression during DMBA-induced hamster buccal pouch carcinogenesis

JH Yoon, YB Kim, Y Kanai, H Endou, DK Kim

ANTICANCER RESEARCH　Vol. 23　No. 5A　p. 3877-3881　2003/09　Research paper (scientific journal)

Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule

P Jutabha, Y Kanai, M Hosoyamada, A Chairoungdua, DK Kim, Y Iribe, E Babu, JY Kim, N Anzai, Chatsudthipong, V, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 30　p. 27930-27938　2003/07　Research paper (scientific journal)

Astrocytomaにおけるsystem LとSystem Aアミノ酸トランスポーターの発現とその意義

苗代 弘, 大谷 直樹, 大井川 秀聡, 福井 伸二, 島 克司, 四ノ宮 成祥, 松尾 洋孝, 遠藤 仁, 金井 好克

Brain Tumor Pathology　Vol. 20　No. Suppl.　p. 77-77　2003/05

Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity

Yoshikatsu Kanai, Hitoshi Endou

Journal of Toxicological Sciences　Vol. 28　No. 1　p. 1-17　2003/02　Research paper (scientific journal)

Isoform selectivity of 3-I-125-iodo-alpha-methyl-L-tyrosine membrane transport in human L-type amino acid transporters

N Shikano, Y Kanai, K Kawai, J Inatomi, DK Kim, N Ishikawa, H Endou

JOURNAL OF NUCLEAR MEDICINE　Vol. 44　No. 2　p. 244-246　2003/02　Research paper (scientific journal)

Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver

Tomoko Muto, Yoshikatsu Kanai, Hitoshi Endou, Takao Watanabe, Mitsuyoshi Moto, Miwa Okamura, Youko Kashida, Kunitoshi Mitsumori

Journal of Toxicologic Pathology　Vol. 16　No. 4　p. 287-290　2003　Research paper (scientific journal)

Initial changes of hepatic glycogen granules and glycogen phosphorylase a after exposure to 7,12-dimethylbenz[a]anthracene in rats.

J. Toxicol. Pathol.　Vol. 16　p. 153-160　2003　Research paper (scientific journal)

Characterization of 3-[I-125]iodo-alpha-methyl-L-tyro sine transport via human L-type amino acid transporter 1

N Shikano, Y Kanai, K Kawai, N Ishikawa, H Endou

NUCLEAR MEDICINE AND BIOLOGY　Vol. 30　No. 1　p. 31-37　2003/01　Research paper (scientific journal)

M6a acts as a nerve growth factor-gated Ca2+ channel in neuronal differentiation

S Mukobata, T Hibino, A Sugiyama, Y Urano, A Inatomi, Y Kanai, H Endo, F Tashiro

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 297　No. 4　p. 722-728　2002/10　Research paper (scientific journal)

Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells

D Kim, Y Kanai, HW Choi, S Tangtrongsup, A Chairoungdua, E Babu, K Tachampa, N Anzai, Y Iribe, H Endou

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1565　No. 1　p. 112-122　2002/09

Molecular identification of a novel carnitine transporter specific to human testis - Insights into the mechanism of carnitine recognition

A Enomoto, MF Wempe, H Tsuchida, HJ Shin, SH Cha, N Anzai, A Goto, A Sakamoto, T Niwa, Y Kanai, MW Anders, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 39　p. 36262-36271　2002/09　Research paper (scientific journal)

[Molecular mechanisms of glucose transport in renal proximal tubules].

Kanai Y

Nihon rinsho. Japanese journal of clinical medicine　Vol. 60 Suppl 7　p. 141-150　2002/07

Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment

KI Hosoya, M Tomi, S Ohtsuki, H Takanaga, S Saeki, Y Kanai, H Endou, M Naito, T Tsuruo, T Terasaki

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 302　No. 1　p. 225-231　2002/07　Research paper (scientific journal)

Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains

H Matsuo, Y Kanai, JY Kim, A Chairoungdua, DK Kim, J Inatomi, Y Shigeta, H Ishimine, S Chaekuntode, K Tachampa, HW Choi, E Babu, J Fukuda, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 23　p. 21017-21026　2002/06　Research paper (scientific journal)

GliomaにおけるCD98の発現と分子標的としての可能性

苗代 弘, 大谷 直樹, 福井 伸二, 四ノ宮 成祥, 島 克司, 松尾 洋孝, 金井 好克

Brain Tumor Pathology　Vol. 19　No. Suppl.　p. 41-41　2002/05

Molecular identification of a renal urate-anion exchanger that regulates blood urate levels

A Enomoto, H Kimura, A Chairoungdua, Y Shigeta, P Jutabha, SH Cha, M Hosoyamada, M Takeda, T Sekine, T Igarashi, H Matsuo, Y Kikuchi, T Oda, K Ichida, T Hosoya, K Shimokata, T Niwa, Y Kanai, H Endou

NATURE　Vol. 417　No. 6887　p. 447-452　2002/05　Research paper (scientific journal)

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): Insights into the mechanisms of substrate recognition

H Uchino, Y Kanai, DK Kim, MF Wempe, A Chairoungdua, E Morimoto, MW Anders, H Endou

MOLECULAR PHARMACOLOGY　Vol. 61　No. 4　p. 729-737　2002/04　Research paper (scientific journal)

B-15 アミノ酸トランスポーター抑制薬のヒト喉頭癌培養細胞HEp-2に対する増殖抑制効果の検討(一般口演,第30回杏林医学会総会)

松田 明史, 金 徒慶, 金井 好克, 長谷川 誠, 遠藤 仁

杏林医学会雑誌　Vol. 33　No. 1　p. 70-70　2002

A-21 アミノ酸トランスポーターLAT1の抑制による抗腫瘍効果のヌードマウス接種腫瘍における検討(一般口演,第30回杏林医学会総会)

寺岡 秀郎, 小林 ゆかり, 金井 好克, 呉屋 朝幸, 遠藤 仁

杏林医学会雑誌　Vol. 33　No. 1　p. 63-63　2002

The role of CD98 in astrocytic neoplasms

Hiroshi Nawashiro, Naoki Otani, Nariyoshi Shinomiya, Shinji Fukui, Namiko Nomura, Akiko Yano, Katsuji Shima, Hirotaka Matsuo, Yoshikatsu Kanai

Human cell: official journal of Human Cell Research Society　Vol. 15　No. 1　p. 25-31　2002　Research paper (scientific journal)

The human T-type amino acid transporter-1: Characterization, gene organization, and chromosomal location

DK Kim, Y Kanai, H Matsuo, JY Kim, A Chairoungdua, Y Kobayashi, A Enomoto, SH Cha, T Goya, H Endou

GENOMICS　Vol. 79　No. 1　p. 95-103　2002/01　Research paper (scientific journal)

Heterodimeric amino acid transporters: Molecular biology and pathological and pharmacological relevance

Y Kanai, H Endou

CURRENT DRUG METABOLISM　Vol. 2　No. 4　p. 339-354　2001/12　Research paper (scientific journal)

Expression of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models

H Ohkame, H Masuda, Y Ishii, Y Kanai

JOURNAL OF SURGICAL ONCOLOGY　Vol. 78　No. 4　p. 265-271　2001/12　Research paper (scientific journal)

Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain

A Chairoungdua, Y Kanai, H Matsuo, J Inatomi, DK Kim, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 52　p. 49390-49399　2001/12　Research paper (scientific journal)

Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes

K Suzuki, Y Ikegaya, S Matsuura, Y Kanai, H Endou, N Matsuki

JOURNAL OF CELL SCIENCE　Vol. 114　No. 20　p. 3717-3725　2001/10　Research paper (scientific journal)

Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

O Yanagida, Y Kanai, A Chairoungdua, DK Kim, H Segawa, T Nii, SH Cha, H Matsuo, J Fukushima, Y Fukasawa, Y Tani, Y Taketani, H Uchino, JY Kim, J Inatomi, Okayasu, I, K Miyamoto, E Takeda, T Goya, H Endou

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1514　No. 2　p. 291-302　2001/10　Research paper (scientific journal)

Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation

T Nii, H Segawa, Y Taketani, Y Tani, M Ohkido, S Kishida, M Ito, H Endou, Y Kanai, E Takeda, K Miyamoto

BIOCHEMICAL JOURNAL　Vol. 358　No. Pt 3　p. 693-704　2001/09　Research paper (scientific journal)

神経膠腫における中性アミノ酸トランスポーターLAT1の発現とLAT1をターゲットにした新たな治療戦略

苗代 弘, 大谷 直樹, 福井 伸二, 島 克司, 四ノ宮 成祥, 松尾 洋隆, 遠藤 仁, 金井 好克

Human Cell　Vol. 14　No. 2　p. P44-P44　2001/07

Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells

JY Kim, Y Kanai, A Chairoungdua, SH Cha, H Matsuo, DK Kim, J Inatomi, H Sawa, Y Ida, H Endou

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1512　No. 2　p. 335-344　2001/06　Research paper (scientific journal)

Astrocytomaにおけるアミノ酸トランスポーターLAT1の発現

苗代 弘, 大谷 直樹, 福井 伸二, 大貫 明, 宮澤 隆仁, 島 克司, 四ノ宮 成祥, 松尾 洋孝, 遠藤 仁, 金井 好克

Brain Tumor Pathology　Vol. 18　No. Suppl.　p. 47-47　2001/05

Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney

SH Cha, T Sekine, J Fukushima, Y Kanai, Y Kobayashi, T Goya, H Endou

MOLECULAR PHARMACOLOGY　Vol. 59　No. 5　p. 1277-1286　2001/05　Research paper (scientific journal)

Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters

DK Kim, Y Kanai, A Chairoungdua, H Matsuo, SH Cha, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 20　p. 17221-17228　2001/05　Research paper (scientific journal)

Human cystinuria-related transporter: Localization and functional characterization

K Mizoguchi, SH Cha, A Chairoungdua, DK Kim, Y Shigeta, H Matsuo, J Fukushima, Y Awa, K Akakura, T Goya, H Ito, H Endou, Y Kanai

KIDNEY INTERNATIONAL　Vol. 59　No. 5　p. 1821-1833　2001/05　Research paper (scientific journal)

A new member of the HCO3- transporter superfamily is an apical anion exchanger of beta-intercalated cells in the kidney

H Tsuganezawa, K Kobayashi, M Iyori, T Araki, A Koizumi, SI Watanabe, A Kaneko, T Fukao, T Monkawa, T Yoshida, DK Kim, Y Kanai, H Endou, M Hayashi, T Saruta

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 11　p. 8180-8189　2001/03　Research paper (scientific journal)

C-16 腫瘍細胞型アミノ酸トランスポーターLAT1の薬理学的特性と特異的インヒビターの探索(一般口演,第29回杏林医学会総会)

中村 祥子, 金 徒慶, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 32　No. 1　p. 108-108　2001

C-15 アミノ酸トランスポーターLAT1の抑制による抗腫瘍効果の検討(一般口演,第29回杏林医学会総会)

小林 ゆかり, 車 碩鎬, 金 徒慶, Chairoungdua Arthit, 金井 好克, 呉屋 朝幸, 遠藤 仁

杏林医学会雑誌　Vol. 32　No. 1　p. 108-108　2001

C-13 シスチン尿症の遺伝子解析(一般口演,第29回杏林医学会総会)

茂田 安弘, 車 碩鎬, Chairoungdua Arthit, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 32　No. 1　p. 107-107　2001

3. 胃癌におけるアミノ酸トランスポータ(LAT1, LAT2, 4F2hc)の発現に関する検討(第28回杏林大学第二外科学教室例会,研究会記録)

福島 淳一, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 32　No. 3　p. 201-201　2001

2. LAT1抑制と腫瘍増殖抑制効果の検討(第28回杏林大学第二外科学教室例会,研究会記録)

小林 ゆかり, 車 碩鎬, 金 徒慶, Chairougdua Arthit, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 32　No. 3　p. 201-201　2001

Expression of L-type amino acid transporter 1 in a rat model of liver metastasis: Positive correlation with tumor size

S Tamai, H Masuda, Y Ishii, S Suzuki, Y Kanai, H Endou

CANCER DETECTION AND PREVENTION　Vol. 25　No. 5　p. 439-445　2001　Research paper (scientific journal)

Expression of a system L neutral amino acid transporter at the blood-brain barrier

Hirotaka Matsuo, Shingo Tsukada, Takahiro Nakata, Arthit Chairoungdua, Do Kyung Kim, Seok Ho Cha, Jun Inatomi, Hiroshi Yorifuji, Jun Fukuda, Hitoshi Endou, Yoshikatsu Kanai

NeuroReport　Vol. 11　No. 16　p. 3507-3511　2000/11/09　Research paper (scientific journal)

The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier

T Kageyama, M Nakamura, A Matsuo, Y Yamasaki, Y Takakura, M Hashida, Y Kanai, M Naito, T Tsuruo, N Minato, S Shimohama

BRAIN RESEARCH　Vol. 879　No. 1-2　p. 115-121　2000/10　Research paper (scientific journal)

Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs

S Wada, M Tsuda, T Sekine, SH Cha, M Kimura, Y Kanai, H Endou

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 294　No. 3　p. 844-849　2000/09　Research paper (scientific journal)

Transport properties of a system y(+)L neutral and basic amino acid transporter - Insights into the mechanisms of substrate recognition

Y Kanai, Y Fukasawa, SH Cha, H Segawa, A Chairoungdua, DK Kim, H Matsuo, JY Kim, K Miyamoto, E Takeda, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 27　p. 20787-20793　2000/07　Research paper (scientific journal)

Involvement of rBAT in Na+-dependent and -independent transport of the neurotransmitter candidate L-DOPA in Xenopus laevis oocytes injected with rabbit small intestinal epithelium poly A(+) RNA

H Ishii, Y Sasaki, Y Goshima, Y Kanai, H Endou, D Ayusawa, H Ono, T Miyamae, Y Misu

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES　Vol. 1466　No. 1-2　p. 61-70　2000/06　Research paper (scientific journal)

Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity

J Nakauchi, H Matsuo, DK Kim, A Goto, A Chairoungdua, SH Cha, J Inatomi, Y Shiokawa, K Yamaguchi, Saito, I, H Endou, Y Kanai

NEUROSCIENCE LETTERS　Vol. 287　No. 3　p. 231-235　2000/06　Research paper (scientific journal)

Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney

N Nakajima, T Sekine, SH Cha, A Tojo, M Hosoyamada, Y Kanai, K Yan, S Awa, H Endou

KIDNEY INTERNATIONAL　Vol. 57　No. 4　p. 1608-1616　2000/04　Research paper (scientific journal)

Identification and characterization of a Na+-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids

Y Fukasawa, H Segawa, JY Kim, A Chairoungdua, DK Kim, H Matsuo, SH Cha, H Endou, Y Kanai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 13　p. 9690-9698　2000/03　Research paper (scientific journal)

Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta

SH Cha, T Sekine, H Kusuhara, E Yu, JY Kim, DK Kim, Y Sugiyama, Y Kanai, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 6　p. 4507-4512　2000/02　Research paper (scientific journal)

Identification and characterization of the high-affinity choline transporter

T Okuda, T Haga, Y Kanai, H Endou, T Ishihara, Katsura, I

NATURE NEUROSCIENCE　Vol. 3　No. 2　p. 120-125　2000/02　Research paper (scientific journal)

D-20 腎近位尿細管シスチントランスポーターのcDNAクローニング : 1回膜貫通型糖タンパク質rBATと連結するトランスポーターの同定(一般口演,第28回杏林医学会総会)

溝口 研一, 車 碩鎬, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 31　No. 1　p. 117-117　2000

14. 胃癌におけるアミノ酸トランスポータ(LAT1, 4F2hc)の発現に関する検討(第27回杏林大学第二外科学教室例会,研究会記録)

福島 淳一, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 31　No. 4　p. 620-621　2000

D-21 asc型中性アミノ酸トランスポーターの同定 : 細胞表面抗原4F2hc(CD98)と連結する新規トランスポーター(一般口演,第28回杏林医学会総会)

中内 淳, 金井 好克, 塩川 芳昭, 齋藤 勇, 遠藤 仁

杏林医学会雑誌　Vol. 31　No. 1　p. 117-117　2000

Molecular cloning and characterization of multispecific organic anion transporter 4,OAT4.

SH Cha, T Sekine, H Kusuhara, Y Sugiyama, Y Kanai, H Endou

CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS　Vol. 1208　p. 331-334　2000　Research paper (international conference proceedings)

The family of amino acid transporters associated with type II membrane glycoproteins: the roles in epithelial transport and cellular nutrition.

Y Kanai, H Segawa, A Chairoungdua, JY Kim, DK Kim, H Endou

CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS　Vol. 1208　p. 311-314　2000　Research paper (international conference proceedings)

Amino acid transporters: molecular structure and physiological roles

Y Kanai, H Segawa, A Chairoungdua, JY Kim, DK Kim, H Matsuo, SH Cha, H Endou

NEPHROLOGY DIALYSIS TRANSPLANTATION　Vol. 15　No. Suppl 6　p. 9-10　2000　Research paper (scientific journal)

Mouse Asc-1 (asc-type amino acid transporter 1) maps to chromosome 7, region B1-B5

H Matsuo, A Chairoungdua, DK Kim, SH Cha, J Fukuda, H Endou, Y Kanai

CHROMOSOME RESEARCH　Vol. 8　No. 5　p. 456-456　2000　Research paper (scientific journal)

Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity

M Takeda, A Tojo, T Sekine, R Hosoyamada, Y Kanai, H Endou

KIDNEY INTERNATIONAL　Vol. 56　No. 6　p. 2128-2136　1999/12　Research paper (scientific journal)

Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities

T Igarashi, J Inatomi, T Sekine, SH Cha, Y Kanai, M Kunimi, K Tsukamoto, H Satoh, M Shimadzu, F Tozawa, T Mori, M Shiobara, G Seki, H Endou

NATURE GENETICS　Vol. 23　No. 3　p. 264-266　1999/11　Research paper (scientific journal)

Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein

A Chairoungdua, H Segawa, JY Kim, K Miyamoto, H Haga, Y Fukui, K Mizoguchi, H Ito, E Takeda, H Endou, Y Kanai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 41　p. 28845-28848　1999/10　Research paper (scientific journal)

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes

A Oku, K Ueta, K Arakawa, T Ishihara, M Nawano, Y Kuronuma, M Matsumoto, A Saito, K Tsujihara, M Anai, T Asano, Y Kanai, H Endou

DIABETES　Vol. 48　No. 9　p. 1794-1800　1999/09　Research paper (scientific journal)

The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1

S Jariyawat, T Sekine, M Takeda, N Apiwattanakul, Y Kanai, S Sophasan, H Endou

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 290　No. 2　p. 672-677　1999/08　Research paper (scientific journal)

Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity

H Segawa, Y Fukasawa, K Miyamoto, E Takeda, H Endou, Y Kanai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 28　p. 19745-19751　1999/07　Research paper (scientific journal)

Transport of ochratoxin A by renal multispecific organic anion transporter 1

M Tsuda, T Sekine, M Takeda, SH Cha, Y Kanai, M Kimura, H Endou

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 289　No. 3　p. 1301-1305　1999/06　Research paper (scientific journal)

Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes

N Apiwattanakul, T Sekine, A Chairoungdua, Y Kanai, N Nakajima, S Sophasan, H Endou

MOLECULAR PHARMACOLOGY　Vol. 55　No. 5　p. 847-854　1999/05　Research paper (scientific journal)

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

H Kusuhara, T Sekine, N Utsunomiya-Tate, M Tsuda, R Kojima, SH Cha, Y Sugiyama, Y Kanai, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 19　p. 13675-13680　1999/05　Research paper (scientific journal)

Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney

A Tojo, T Sekine, N Nakajima, M Hosoyamada, Y Kanai, K Kimura, H Endou

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　Vol. 10　No. 3　p. 464-471　1999/03　Research paper (scientific journal)

C-17 ヒトテラトカルシノーマ細胞PA-1からの中性アミノ酸トランスポーターhLAT1のクローニングおよび機能解析(一般口演,第27回杏林医学会総会)

柳田 修, 金井 好克, 呉屋 朝幸, 遠藤 仁

杏林医学会雑誌　Vol. 30　No. 1　p. 153-153　1999

C-18 中性アミノ酸トランスポーターLAT1の類縁トランスポーターの探索(一般口演,第27回杏林医学会総会)

大羽 尚子, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 30　No. 1　p. 153-153　1999

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

Makoto Hosoyamada, Takashi Sekine, Yoshikatsu Kanai, Hitoshi Endou

American Journal of Physiology - Renal Physiology　Vol. 276　No. 1　p. F122-F128　1999/01　Research paper (scientific journal)

Amino acid transporter molecule as a drug target

Hitoshi Endou, Yoshikatsu Kanai

Folia Pharmacologica Japonica　Vol. 114　No. 1　1999　Research paper (scientific journal)

Molecular biology of multispecific organic anion transporter family (OAT family)

Takashi Sekine, Seok Ho Cha, Yoshikatsu Kanai, Hitoshi Endou

Clinical and Experimental Nephrology　Vol. 3　No. 4　p. 237-243　1999　Research paper (scientific journal)

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

M Hosoyamada, T Sekine, Y Kanai, H Endou

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 276　No. 1　p. F122-F128　1999/01　Research paper (scientific journal)

Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine

T Sekine, H Kusuhara, N Utsunomiya-Tate, M Tsuda, Y Sugiyama, Y Kanai, H Endou

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 251　No. 2　p. 586-591　1998/10　Research paper (scientific journal)

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

Y Kanai, H Segawa, K Miyamoto, H Uchino, E Takeda, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 273　No. 37　p. 23629-23632　1998/09　Research paper (scientific journal)

Cloning, functional characterization, and localization of a rat renal Na(+)-dicarboxylate transporter

T Sekine, SH Cha, M Hosoyamada, Y Kanai, N Watanabe, Y Furuta, K Fukuda, T Igarashi, H Endou

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 275　No. 2　p. F298-F305　1998/08　Research paper (scientific journal)

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

T Sekine, SH Cha, M Tsuda, N Apiwattanakul, N Nakajima, Y Kanai, H Endou

FEBS LETTERS　Vol. 429　No. 2　p. 179-182　1998/06　Research paper (scientific journal)

C-26 Na^+/グルコーストランスポーターファミリーのヒト腎からのクローニング及び調節因子RS1による機能修飾(一般口演,第26回杏林医学会総会)

大羽 尚子, 楯 直子, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 29　No. 1　p. 160-161　1998

Expression cloning using Xenopus laevis clocytes

Michael F. Romero, Yoshikatsu Kanai, Hironh Gunshin, Matthias A. Hediger

NEUROTRANSMITTER TRANSPORTERS　Vol. 296　p. 17-52　1998　Research paper (scientific journal)

A novel renal multispecific organic anion transporter(PAH transporter) : its structure and functional characteristics.

Nova Acta Leopldina　Vol. 306　p. 119-126　1998　Research paper (scientific journal)

Localization of the high-affinity glutamate transporter EAAC1 in rat kidney

Chairat Shayakul, Yoshikatsu Kanai, Wen-Sen Lee, Dennis Brown, Jeffrey D. Rothstein, Matthias A. Hediger

American Journal of Physiology - Renal Physiology　Vol. 273　No. 6　p. F1023-F1029　1997/12　Research paper (scientific journal)

Localization of the high-affinity glutamate transporter EAAC1 in rat kidney

C Shayakul, Y Kanai, WS Lee, D Brown, JD Rothstein, MA Hediger

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 273　No. 6　p. F1023-F1029　1997/12　Research paper (scientific journal)

Tissue specific variants of glutamate transporter GLT-1

N UtsunomiyaTate, H Endou, Y Kanai

FEBS LETTERS　Vol. 416　No. 3　p. 312-316　1997/10　Research paper (scientific journal)

Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications

Y Kanai

CURRENT OPINION IN CELL BIOLOGY　Vol. 9　No. 4　p. 565-572　1997/08　Research paper (scientific journal)

Expression cloning and characterization of a novel multispecific organic anion transporter

T Sekine, N Watanabe, M Hosoyamada, Y Kanai, H Endou

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 30　p. 18526-18529　1997/07　Research paper (scientific journal)

D-6 グルタミン酸トランスポーターの基質結合部位に関する検討(一般口演,第25回杏林医学会総会)

楯 直子, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 28　No. 1　p. 126-126　1997

D-8 マウス脳からの神経伝達物質トランスポーター類縁蛋白のcDNAクローニング(一般口演,第25回杏林医学会総会)

大羽 尚子, 楯 直子, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 28　No. 1　p. 127-127　1997

A novel Na+-dependent amino acid transporter with a high affinity to glutamine

H Endou, Y Kanai, N UtsunomiyaTate, M Hosoyamada

NUTRITIONAL AND ACID-BASE ASPECTS OF AMINO ACID METABOLISM　Vol. 121　p. 31-36　1997　Research paper (scientific journal)

Substrate binding sites of glutamate transporters and structurally related neutral amino acid transporters

Yoshikatsu Kanai

Japanese Journal of Physiology　Vol. 47　No. 1　p. S55-S56　1997　Research paper (international conference proceedings)

Structure, regulation and physiological roles of urea transporters

MA Hediger, CP Smith, GF You, WS Lee, Y Kanai, C Shayakul

KIDNEY INTERNATIONAL　Vol. 49　No. 6　p. 1615-1623　1996/06　Research paper (scientific journal)

Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter

N UtsunomiyaTate, H Endou, Y Kanai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 271　No. 25　p. 14883-14890　1996/06　Research paper (scientific journal)

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

JD Rothstein, M DykesHoberg, CA Pardo, LA Bristol, L Jin, RW Kuncl, Y Kanai, MA Hediger, YF Wang, JP Schielke, DF Welty

NEURON　Vol. 16　No. 3　p. 675-686　1996/03　Research paper (scientific journal)

D-4 テラトカルシノーマ細胞PA-1における中性アミノ酸トランスポーターの発現(一般口演,第24回杏林医学会総会)

金 珠玉, 楯 直子, 奥 哲, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 27　No. 1　p. 133-134　1996

D-3 新規中性アミノ酸トランスポーターSNAT 1のcDNAクローニング(一般口演,第24回杏林医学会総会)

楯 直子, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 27　No. 1　p. 133-133　1996

MOLECULAR CHARACTERISTICS OF NA+-COUPLED GLUCOSE TRANSPORTERS IN ADULT AND EMBRYONIC RAT-KIDNEY

GF YOU, WS LEE, EJG BARROS, Y KANAI, TL HUO, S KHAWAJA, RG WELLS, SK NIGAM, MA HEDIGER

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 270　No. 49　p. 29365-29371　1995/12　Research paper (scientific journal)

Neuronal high-affinity glutamate transport in the rat central nervous system

Y Kanai, PG Bhide, M DiFiglia, MA Hediger

NEUROREPORT　Vol. 6　No. 17　p. 2357-2362　1995/11　Research paper (scientific journal)

ELECTROGENIC PROPERTIES OF THE EPITHELIAL AND NEURONAL HIGH-AFFINITY GLUTAMATE TRANSPORTER

Y KANAI, S NUSSBERGER, MF ROMERO, WF BORON, SC HEBERT, MA HEDIGER

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 270　No. 28　p. 16561-16568　1995/07　Research paper (scientific journal)

D-24 エクソヌクレアーゼIIIデリーション法を用いたマウスグルタミン酸トランスポーターcDNAのシークエンシング(一般口演,第23回杏林医学会総会)

大羽 尚子, 楯 直子, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 26　No. 1　p. 131-131　1995

D-27 上皮・神経細胞型グルタミン酸トランスポーターEAAC1のゲノミックDNAクローニング(一般口演,第23回杏林医学会総会)

菅野 賢吉, 金井 好克, 遠藤 仁

杏林医学会雑誌　Vol. 26　No. 1　p. 132-133　1995

MAMMALIAN ION-COUPLED SOLUTE TRANSPORTERS

MA HEDIGER, Y KANAI, GF YON, S NUSSBERGER

JOURNAL OF PHYSIOLOGY-LONDON　Vol. 482P　p. S7-S17　1995/01　Research paper (scientific journal)

N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE (FG-7142) - AN ANXIOGENIC AGENT IN CIGARETTE-SMOKE CONDENSATE AND ITS MECHANISM OF FORMATION

S MANABE, Y JUAN, O WADA, A UEKI, Y KANAI

ENVIRONMENTAL POLLUTION　Vol. 89　No. 3　p. 329-335　1995　Research paper (scientific journal)

THE NEURONAL AND EPITHELIAL HUMAN HIGH-AFFINITY GLUTAMATE TRANSPORTER - INSIGHTS INTO STRUCTURE AND MECHANISM OF TRANSPORT

Y KANAI, M STELZNER, S NUSSBERGER, S KHAWAJA, SC HEBERT, CP SMITH, MA HEDIGER

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 269　No. 32　p. 20599-20606　1994/08　Research paper (scientific journal)

EXPRESSION OF A RABBIT RENAL ASCORBIC-ACID TRANSPORTER IN XENOPUS-LAEVIS OOCYTES

DL DYER, Y KANAI, MA HEDIGER, SA RUBIN, HM SAID

AMERICAN JOURNAL OF PHYSIOLOGY　Vol. 267　No. 1　p. C301-C306　1994/07　Research paper (scientific journal)

EXPRESSION CLONING AND CHARACTERIZATION OF THE GLUTAMATE TRANSPORTER IN NEURONS

MA HEDIGER, Y KANAI

RENAL PHYSIOLOGY AND BIOCHEMISTRY　Vol. 17　No. 3-4　p. 161-164　1994/05　Research paper (scientific journal)

EXPRESSION CLONING OF A MAMMALIAN PROTON-COUPLED OLIGOPEPTIDE TRANSPORTER

YJ FEI, Y KANAI, S NUSSBERGER, GANAPATHY, V, FH LEIBACH, MF ROMERO, SK SINGH, WF BORON, MA HEDIGER

NATURE　Vol. 368　No. 6471　p. 563-566　1994/04　Research paper (scientific journal)

THE HIGH-AFFINITY NA+/GLUCOSE COTRANSPORTER - REEVALUATION OF FUNCTION AND DISTRIBUTION OF EXPRESSION

WS LEE, Y KANAI, RG WELLS, MA HEDIGER

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 269　No. 16　p. 12032-12039　1994/04　Research paper (scientific journal)

ASSIGNMENT OF THE GENE CODING FOR THE HUMAN HIGH-AFFINITY GLUTAMATE TRANSPORTER EAAC1 TO 9P24 - POTENTIAL ROLE IN DICARBOXYLIC AMINOACIDURIA AND NEURODEGENERATIVE DISORDERS

CP SMITH, S WEREMOWICZ, Y KANAI, M STELZNER, CC MORTON, MA HEDIGER

GENOMICS　Vol. 20　No. 2　p. 335-336　1994/03　Research paper (scientific journal)

Roles of glutamate trasporters in neuronal cell death.

J. Toxicol. Sci.　Vol. 19　p. 295-297　1994　Research paper (scientific journal)

THE HUMAN KIDNEY LOW-AFFINITY NA+/GLUCOSE COTRANSPORTER SGLT2 - DELINEATION OF THE MAJOR RENAL REABSORPTIVE MECHANISM FOR D-GLUCOSE

Y KANAI, WS LEE, GF YOU, D BROWN, MA HEDIGER

JOURNAL OF CLINICAL INVESTIGATION　Vol. 93　No. 1　p. 397-404　1994/01　Research paper (scientific journal)

A NEW FAMILY OF NEUROTRANSMITTER TRANSPORTERS - THE HIGH-AFFINITY GLUTAMATE TRANSPORTERS

Y KANAI, CP SMITH, MA HEDIGER

FASEB JOURNAL　Vol. 7　No. 15　p. 1450-1459　1993/12　Research paper (scientific journal)

CLONING AND CHARACTERIZATION OF THE VASOPRESSIN-REGULATED UREA TRANSPORTER

GF YOU, CP SMITH, Y KANAI, WS LEE, M STELZNER, MA HEDIGER

NATURE　Vol. 365　No. 6449　p. 844-847　1993/10　Research paper (scientific journal)

THE ELUSIVE TRANSPORTERS WITH A HIGH-AFFINITY FOR GLUTAMATE

Y KANAI, CP SMITH, MA HEDIGER

TRENDS IN NEUROSCIENCES　Vol. 16　No. 9　p. 365-370　1993/09　Research paper (scientific journal)

IDENTIFICATION OF A NEW FAMILY OF PROTEINS INVOLVED IN AMINO-ACID-TRANSPORT

MA HEDIGER, Y KANAI, WS LEE, RG WELLS

MOLECULAR BIOLOGY AND FUNCTION OF CARRIER PROTEINS　Vol. 48　p. 301-314　1993　Research paper (international conference proceedings)

EXPRESSION OF MESSENGER-RNA (D2) ENCODING A PROTEIN INVOLVED IN AMINO-ACID-TRANSPORT IN S3-PROXIMAL TUBULE

Y KANAI, MG STELZNER, WS LEE, RG WELLS, D BROWN, MA HEDIGER

AMERICAN JOURNAL OF PHYSIOLOGY　Vol. 263　No. 6　p. F1087-F1093　1992/12　Research paper (scientific journal)

PRIMARY STRUCTURE AND FUNCTIONAL-CHARACTERIZATION OF A HIGH-AFFINITY GLUTAMATE TRANSPORTER

Y KANAI, MA HEDIGER

NATURE　Vol. 360　No. 6403　p. 467-471　1992/12　Research paper (scientific journal)

CLONING OF A HUMAN KIDNEY CDNA WITH SIMILARITY TO THE SODIUM-GLUCOSE COTRANSPORTER

RG WELLS, AM PAJOR, Y KANAI, E TURK, EM WRIGHT, MA HEDIGER

AMERICAN JOURNAL OF PHYSIOLOGY　Vol. 263　No. 3　p. F459-F465　1992/09　Research paper (scientific journal)

THE 4F2 ANTIGEN HEAVY-CHAIN INDUCES UPTAKE OF NEUTRAL AND DIBASIC AMINO-ACIDS IN XENOPUS OOCYTES

RG WELLS, WS LEE, Y KANAI, JM LEIDEN, MA HEDIGER

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 267　No. 22　p. 15285-15288　1992/08　Research paper (scientific journal)

PHARMACOTOXICOLOGICAL ASPECTS OF CARCINOGENIC TRYPTOPHAN PYROLYSIS PRODUCTS IN THE ENVIRONMENT

S MANABE, O WADA, Y KANAI

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL　Vol. 26　No. 8　p. 1449-1469　1991　Research paper (scientific journal)

Carcinogenic amino-α-carbolines and amino-γ-carbolines in cooked foods and soy sauce

Environ. Sci.　Vol. 1　p. 11-19　1991　Research paper (scientific journal)

Urinary excretion levels of carcinogenic glutamic acid pyrolysis products and their N-acetyl derivatives in humans

Y. Kanai, O. Wada, S. Manabe

Japanese Journal of Hygiene　Vol. 46　No. 4　p. 922-929　1991　Research paper (scientific journal)

DETECTION OF CARCINOGENIC AMINO-ALPHA-CARBOLINES AND AMINO-GAMMA-CARBOLINES IN DIESEL-EXHAUST PARTICLES

S MANABE, S IZUMIKAWA, K ASAKUNO, O WADA, Y KANAI

ENVIRONMENTAL POLLUTION　Vol. 70　No. 3　p. 255-265　1991　Research paper (scientific journal)

SIMULTANEOUS DETERMINATION OF AMINO-ALPHA-CARBOLINES AND AMINO-GAMMA-CARBOLINES IN CIGARETTE-SMOKE CONDENSATE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

S MANABE, O WADA, Y KANAI

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS　Vol. 529　No. 1　p. 125-133　1990/07　Research paper (scientific journal)

DETECTION OF CARCINOGENIC GLUTAMIC-ACID PYROLYSIS PRODUCTS IN CIGARETTE-SMOKE CONDENSATE

Y KANAI, O WADA, S MANABE

CARCINOGENESIS　Vol. 11　No. 6　p. 1001-1003　1990/06　Research paper (scientific journal)

ANTAGONISM OF GAMMA-AMINOBUTYRIC ACIDA RECEPTOR-MEDIATED RESPONSES BY AMINO-GAMMA-CARBOLINES

Y KANAI, O WADA, S MANABE

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 252　No. 3　p. 1269-1276　1990/03　Research paper (scientific journal)

SUPPRESSION OF GABA-INDUCED CHLORIDE CURRENT BY 3-AMINO-1-METHYL-5H-PYRIDO[4,3-B]INDOLE (TRP-P-2)

Y KANAI, T AOSAKI, O WADA, S MANABE

EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 166　No. 3　p. 553-556　1989/08　Research paper (scientific journal)

EXPOSURE LEVEL MONITOR OF 3-AMINO-1,4-DIMETHYL-5H-PYRIDO[4,3-B]INDOLE, A DIETARY CARCINOGEN, IN RABBITS

S MANABE, Y KANAI, O WADA

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS　Vol. 14　No. 1　p. 34-41　1989　Research paper (scientific journal)

INVITRO AND INVIVO N-ACETYLATION OF CARCINOGENIC GLUTAMIC-ACID PYROLYSIS PRODUCTS IN HUMANS

Y KANAI, S MANABE, O WADA

CARCINOGENESIS　Vol. 9　No. 12　p. 2179-2184　1988/12　Research paper (scientific journal)

CARCINOGENIC GLUTAMIC-ACID PYROLYSIS PRODUCT IN THE DIALYSATE OF UREMIC PATIENTS TREATED BY CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS

H YANAGISAWA, S MANABE, Y KANAI, O WADA

CLINICAL NEPHROLOGY　Vol. 30　No. 2　p. 73-78　1988/08　Research paper (scientific journal)

CARCINOGENIC TRYPTOPHAN PYROLYSIS PRODUCTS POTENT INHIBITORS OF TYPE-A MONOAMINE-OXIDASE AND THE PLATELET RESPONSE TO 5-HYDROXYTRYPTAMINE

S MANABE, Y KANAI, S ISHIKAWA, O WADA

JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY　Vol. 26　No. 5　p. 265-270　1988/05　Research paper (scientific journal)

DETECTION OF N-ACETYL DERIVATIVE OF 2-AMINO-6-METHYLDIPYRIDO[1,2-A-3',2'-D]IMIDAZOLE (GLU-P-1) IN GLU-P-1-INJECTED RATS

Y KANAI, S MANABE, O WADA

MUTATION RESEARCH　Vol. 207　No. 2　p. 63-67　1988/02　Research paper (scientific journal)

Carcinogenic Tryptophan Pyrolysis Products Potent Inhibitors of Type A Monoamine Oxidase and the Platelet Response to 5-Hydroxytryptamine

Shigeo Manabe, Yoshikatsu Kanai, Shinsuke Ishikawa, Osamu Wada

Clinical Chemistry and Laboratory Medicine　Vol. 26　No. 5　p. 265-270　1988　Research paper (scientific journal)

Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-α: 3′,2′-d]imidazole (Glu-P-1) in Glu-P-1-injected rats

Yoshikatsu Kanai, Shigeo Manabe, Osamu Wada

Mutation Research Letters　Vol. 207　No. 2　p. 63-67　1988　Research paper (scientific journal)

PRESENCE OF CARCINOGENIC GLUTAMIC-ACID PYROLYSIS PRODUCTS IN HUMAN CATARACTOUS LENS

S MANABE, H YANAGISAWA, Y KANAI, O WADA

OPHTHALMIC RESEARCH　Vol. 20　No. 1　p. 20-26　1988/01　Research paper (scientific journal)

DETECTION OF CARCINOGENIC GLUTAMIC-ACID PYROLYSIS PRODUCTS IN WORCESTERSHIRE SAUCE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

S MANABE, Y KANAI, H YANAGISAWA, K TOHYAMA, S ISHIKAWA, Y KITAGAWA, O WADA

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS　Vol. 11　No. 3　p. 379-388　1988　Research paper (scientific journal)

ACCUMULATION OF 2-AMINO-6-METHYLDIPYRIDO[1,2-A-3',2'-D]IMIDAZOLE AND 2-AMINODIPYRIDO[1,2-A-3',2'-D]IMIDAZOLE, CARCINOGENIC GLUTAMIC-ACID PYROLYSIS PRODUCTS, IN PLASMA OF PATIENTS WITH UREMIA

S MANABE, H YANAGISAWA, S ISHIKAWA, Y KITAGAWA, Y KANAI, O WADA

CANCER RESEARCH　Vol. 47　No. 22　p. 6150-6155　1987/11　Research paper (scientific journal)

INHIBITORY EFFECTS OF TRYPTOPHAN PYROLYSIS PRODUCTS ON HUMAN-PLATELET AGGREGATION THROUGH INHIBITION OF PROSTAGLANDIN ENDOPEROXIDE SYNTHETASE

S ISHIKAWA, S MANABE, H YANAGISAWA, Y KITAGAWA, Y KANAI, O WADA

FOOD AND CHEMICAL TOXICOLOGY　Vol. 25　No. 11　p. 829-&　1987/11　Research paper (scientific journal)

LONG-TERM EFFECTS OF 3-ACETYLPYRIDINE-INDUCED DESTRUCTION OF CEREBELLAR CLIMBING FIBERS ON PURKINJE-CELL INHIBITION OF VESTIBULOSPINAL TRACT CELLS OF THE RAT

L KARACHOT, M ITO, Y KANAI

EXPERIMENTAL BRAIN RESEARCH　Vol. 66　No. 2　p. 229-246　1987　Research paper (scientific journal)