Significant Role of Autophagy in Melanosomal Degradation of Dermal Macrophages - Therapeutic Insight Regarding Hyperpigmentation with Uncertain Etiology.

Kisumi Takiguchi, Kazunori Yokoi, Daiki Murase, Masafumi Yokota, Keigo Kawabata, Yoshito Takahashi, Satoshi Minami, Shuhei Nakamura, Tamotsu Yoshimori, Rei Watanabe, Manabu Fujimoto, Atsushi Tanemura

The Journal of investigative dermatology　2024/09/25　Research paper (scientific journal)

Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy.

Keisuke Tabata, Kenta Imai, Koki Fukuda, Kentaro Yamamoto, Hayato Kunugi, Toshiharu Fujita, Tatsuya Kaminishi, Christian Tischer, Beate Neumann, Sabine Reither, Fatima Verissimo, Rainer Pepperkok, Tamotsu Yoshimori, Maho Hamasaki

Nature communications　Vol. 15　No. 1　p. 7194-7194　2024/08/21　Research paper (scientific journal)

YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus.

Shinri Kitta, Tatsuya Kaminishi, Momoko Higashi, Takayuki Shima, Kohei Nishino, Nobuhiro Nakamura, Hidetaka Kosako, Tamotsu Yoshimori, Akiko Kuma

The EMBO journal　Vol. 43　No. 14　p. 2954-2978　2024/07　Research paper (scientific journal)

MondoA and AKI and AKI-to-CKD Transition.

Shihomi Maeda, Shinsuke Sakai, Yoshitsugu Takabatake, Takeshi Yamamoto, Satoshi Minami, Jun Nakamura, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Sho Matsui, Atsuhiro Imai, Ryuya Edahiro, Hitomi Yamamoto-Imoto, Isao Matsui, Seiji Takashima, Ryoichi Imamura, Norio Nonomura, Motoko Yanagita, Yukinori Okada, Andrea Ballabio, Shuhei Nakamura, Tamotsu Yoshimori, Yoshitaka Isaka

Journal of the American Society of Nephrology : JASN　2024/05/31　Research paper (scientific journal)

The Rubicon-WIPI axis regulates exosome biogenesis during aging

Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, Yoshio Kato, Ryuya Edahiro, Ryosuke Kawagoe, Takako Taniguchi, Yoko Tanaka, Takayuki Shima, Keisuke Tabata, Miki Iwatani, Nao Bekku, Rikinari Hanayama, Yukinori Okada, Takayuki Akimoto, Hidetaka Kosako, Akiko Takahashi, Iichiro Shimomura, Yasushi Sakata, Tamotsu Yoshimori

Nature cell biology　2024/05/10　Research paper (scientific journal)

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence

Mengying Cui, Koji Yamano, Kenichi Yamamoto, Hitomi Yamamoto-Imoto, Satoshi Minami, Takeshi Yamamoto, Sho Matsui, Tatsuya Kaminishi, Takayuki Shima, Monami Ogura, Megumi Tsuchiya, Kohei Nishino, Brian T. Layden, Hisakazu Kato, Hidesato Ogawa, Shinya Oki, Yukinori Okada, Yoshitaka Isaka, Hidetaka Kosako, Noriyuki Matsuda, Tamotsu Yoshimori, Shuhei Nakamura

Proceedings of the National Academy of Sciences　Vol. 121　No. 2　2024/01/03　Research paper (scientific journal)

Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes

Na Yeon Park, Doo Sin Jo, Hyun Jun Park, Ji Eun Bae, Yong Hwan Kim, Joon Bum Kim, Ha Jung Lee, Sung Hyun Kim, Hyunjung Choi, Hyun Shik Lee, Tamotsu Yoshimori, Dong Seok Lee, Jin A. Lee, Pansoo Kim, Dong Hyung Cho

Autophagy　2024　Research paper (scientific journal)

Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles

Keita Kakuda, Kensuke Ikenaka, Akiko Kuma, Junko Doi, César Aguirre, Nan Wang, Takahiro Ajiki, Chi-Jing Choong, Yasuyoshi Kimura, Shaymaa Mohamed Mohamed Badawy, Takayuki Shima, Shuhei Nakamura, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Tamotsu Yoshimori, Hideki Mochizuki

Proceedings of the National Academy of Sciences　Vol. 121　No. 1　2023/12/26　Research paper (scientific journal)

The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps.

Takayuki Shima, Monami Ogura, Ruriko Matsuda, Shuhei Nakamura, Natsuko Jin, Tamotsu Yoshimori, Akiko Kuma

The Journal of cell biology　Vol. 222　No. 12　2023/12/04　Research paper (scientific journal)

Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.

Monami Ogura, Tatsuya Kaminishi, Takayuki Shima, Miku Torigata, Nao Bekku, Keisuke Tabata, Satoshi Minami, Kohei Nishino, Akiko Nezu, Maho Hamasaki, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura

EMBO reports　2023/11/21　Research paper (scientific journal)

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity.

Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 39　2023/09/26　Research paper (scientific journal)

Opposing roles of RUBCN isoforms in autophagy and memory B cell generation.

Chao-Yuan Tsai, Shuhei Sakakibara, Yu-Diao Kuan, Hiroko Omori, Maruwa Ali El Hussien, Daisuke Okuzaki, Shiou-Ling Lu, Takeshi Noda, Keisuke Tabata, Shuhei Nakamura, Tamotsu Yoshimori, Hitoshi Kikutani

Science signaling　Vol. 16　No. 803　2023/09/19　Research paper (scientific journal)

The P4-ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast

Irene Pazos, Marta Puig-Tintó, Laura Betancur, Jorge Cordero, Nereida Jiménez-Menéndez, Marc Abella, Altair C. Hernández, Ana G. Duran, Emi Adachi-Fernández, Carla Belmonte-Mateos, Susana Sabido-Bozo, Sébastien Tosi, Akiko Nezu, Baldomero Oliva, Julien Colombelli, Todd R. Graham, Tamotsu Yoshimori, Manuel Muñiz, Maho Hamasaki, Oriol Gallego

EMBO Reports　Vol. 24　No. 5　2023/05/04　Research paper (scientific journal)

TFEB-mediated lysosomal exocytosis alleviates high fat diet-induced lipotoxicity in the kidney.

Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

JCI insight　Vol. 8　No. 4　2023/01/17　Research paper (scientific journal)

V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy.

Xiaotong Jia, Anastasia Knyazeva, Yu Zhang, Sergio Castro-Gonzalez, Shuhei Nakamura, Lars-Anders Carlson, Tamotsu Yoshimori, Dale P Corkery, Yao-Wen Wu

The Journal of cell biology　Vol. 221　No. 12　2022/12/05　Research paper (scientific journal)

Author Correction: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori

Nature cell biology　Vol. 24　No. 11　p. 1677-1679　2022/11　Research paper (scientific journal)

Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy

Hirofumi Teranishi, Keisuke Tabata, Marika Saeki, Tetsuo Umemoto, Tomohisa Hatta, Takanobu Otomo, Kentaro Yamamoto, Toru Natsume, Tamotsu Yoshimori, Maho Hamasaki

Cell Reports　Vol. 40　No. 11　p. 111349-111349　2022/09　Research paper (scientific journal)

PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.

Yukako Oe, Keita Kakuda, Shin-Ichiro Yoshimura, Naohiro Hara, Junya Hasegawa, Seigo Terawaki, Yasuyoshi Kimura, Kensuke Ikenaka, Shiro Suetsugu, Hideki Mochizuki, Tamotsu Yoshimori, Shuhei Nakamura

PLoS genetics　Vol. 18　No. 6　2022/06　Research paper (scientific journal)

Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response.

Yamamuro T, Nakamura S, Yanagawa K, Tokumura A, Kawabata T, Fukuhara A, Teranishi H, Hamasaki M, Shimomura I, Yoshimori T

Autophagy　p. 1-11　2022/03　Research paper (scientific journal)

Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis.

Yamamoto-Imoto H, Minami S, Shioda T, Yamashita Y, Sakai S, Maeda S, Yamamoto T, Oki S, Takashima M, Yamamuro T, Yanagawa K, Edahiro R, Iwatani M, So M, Tokumura A, Abe T, Imamura R, Nonomura N, Okada Y, Ayer E. D, Ogawa H, Hara E, Takabatake Y, Isaka Y, Nakamura S, Yoshimori T

Cell Rep.　Vol. 38　No. 9　p. 110444-110444　2022/03　Research paper (scientific journal)

Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis

Yoshida G, Kawabata T, Takamatsu H, Saita S, Nakamura S, Nishikawa K, Fujiwara M, Enokidani Y, Yamamuro T, Tabata K, Hamasaki M, Ishii M, Kumanogoh A, Yoshimori T

Autophagy　p. 1-10　2022/01　Research paper (scientific journal)

Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload.

Yasuhiro Akazawa, Manabu Taneike, Hiromichi Ueda, Rika Kitazume-Taneike, Tomokazu Murakawa, Ryuta Sugihara, Hiroki Yorifuji, Hiroki Nishida, Kentaro Mine, Ayana Hioki, Shigemiki Omiya, Hiroyuki Nakayama, Osamu Yamaguchi, Tamotsu Yoshimori, Yasushi Sakata, Kinya Otsu

Sci. Rep.　Vol. 12　No. 1　p. 41-41　2022/01　Research paper (scientific journal)

Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.

Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, Yoshimori T

PLoS Genet.　Vol. 17　No. 8　p. e1009688-e1009688　2021/08　Research paper (scientific journal)

Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration.

Satoru Ando, Noriyasu Hashida, Daisuke Yamashita, Tsuyoshi Kawabata, Kazunobu Asao, Satoshi Kawasaki, Kazushi Sakurai, Tamotsu Yoshimori, Kohji Nishida

Biochemical and biophysical research communications　Vol. 551　p. 148-154　2021/03/16　Research paper (scientific journal)

TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis

Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T, Nakanishi M

Autophagy.　Vol. 17　No. 11　p. 1-18　2021/03　Research paper (scientific journal)

THOC4 regulates energy homeostasis by stabilizing TFEB mRNA during prolonged starvation

Fujita T, Kubo S, Shioda T, Tokumura A, Minami S, Tsuchiya M, Isaka Y, Ogawa H, Hamasaki M, Yu L, Yoshimori T, Nakamura S

J Cell Sci.　Vol. 134　No. 6　2021/03　Research paper (scientific journal)

Vacuolar protein Tag1 and Atg1–Atg13 regulate autophagy termination during persistent starvation in yeast

Shintaro Kira, Masafumi Noguchi, Yasuhiro Araki, Yu Oikawa, Tamotsu Yoshimori, Aiko Miyahara, Takeshi Noda

Journal of Cell Science　p. jcs.253682-jcs.253682　2021/02/03　Research paper (scientific journal)

Alternative mitochondrial quality control mediated by extracellular release

Chi-Jing Choong, Tatsusada Okuno, Kensuke Ikenaka, Kousuke Baba, Hideki Hayakawa, Masato Koike, Mutsumi Yokota, Junko Doi, Keita Kakuda, Toshihide Takeuchi, Akiko Kuma, Shuhei Nakamura, Yoshitaka Nagai, Seiichi Nagano, Tamotsu Yoshimori, Hideki Mochizuki

Autophagy　p. 1-13　2020/12　Research paper (scientific journal)

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Tadashi Yamamuro, Tsuyoshi Kawabata, Atsunori Fukuhara, Shotaro Saita, Shuhei Nakamura, Hikari Takeshita, Mari Fujiwara, Yusuke Enokidani, Gota Yoshida, Keisuke Tabata, Maho Hamasaki, Akiko Kuma, Koichi Yamamoto, Iichiro Shimomura, Tamotsu Yoshimori

Nature Communications　Vol. 11　No. 1　2020/12　Research paper (scientific journal)

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Masahiro Wakita, Akiko Takahashi, Osamu Sano, Tze Mun Loo, Yoshinori Imai, Megumi Narukawa, Hidehisa Iwata, Tatsuyuki Matsudaira, Shimpei Kawamoto, Naoko Ohtani, Tamotsu Yoshimori, Eiji Hara

Nature Communications　Vol. 11　No. 1　2020/12/01　Research paper (scientific journal)

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T

Nat. Cell Biol　Vol. 22　No. 10　p. 1252-1263　2020/10　Research paper (scientific journal)

Autophagy Declines with Premature Skin Aging resulting in Dynamic Alterations in Skin Pigmentation and Epidermal Differentiation.

Daiki Murase, Ayumi Kusaka-Kikushima, Akira Hachiya, Rachel Fullenkamp, Anita Stepp, Asuka Imai, Mizuki Ueno, Keigo Kawabata, Yoshito Takahashi, Tadashi Hase, Atsushi Ohuchi, Shuhei Nakamura, Tamotsu Yoshimori

International journal of molecular sciences　Vol. 21　No. 16　2020/08/09　Research paper (scientific journal)

ERdj8 governs the size of autophagosomes during the formation process.

Yo-Hei Yamamoto, Ayano Kasai, Hiroko Omori, Tomoe Takino, Munechika Sugihara, Tetsuo Umemoto, Maho Hamasaki, Tomohisa Hatta, Tohru Natsume, Richard I Morimoto, Ritsuko Arai, Satoshi Waguri, Miyuki Sato, Ken Sato, Shoshana Bar-Nun, Tamotsu Yoshimori, Takeshi Noda, Kazuhiro Nagata

The Journal of cell biology　Vol. 219　No. 8　2020/08/03　Research paper (scientific journal)

Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance.

Shuhei Aoyama, Yuya Nishida, Yoshio Fujitani, Ayako Fukunaka, Takeshi Miyatsuka, Luka Suzuki, Miwa Himuro, Tamotsu Yoshimori, Hirotaka Watada

Endocrine journal　Vol. 67　No. 11　p. 1119-1126　2020/07/16　Research paper (scientific journal)

Structural Basis for Autophagy Inhibition by the Human Rubicon-Rab7 Complex

Hersh K Bhargava, Keisuke Tabata, Jordan M Byck, Maho Hamasaki, Daniel P Farrell, Ivan Anishchenko, Frank DiMaio, Young Jun Im, Tamotsu Yoshimori, James H Hurley

Proc Natl Acad Sci U S A　Vol. 117　No. 29　p. 17003-17010　2020/07　Research paper (scientific journal)

Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.

Rei Unno, Tsuyoshi Kawabata, Kazumi Taguchi, Teruaki Sugino, Shuzo Hamamoto, Ryosuke Ando, Atsushi Okada, Kenjiro Kohri, Tamotsu Yoshimori, Takahiro Yasui

Autophagy　Vol. 16　No. 4　p. 709-723　2020/04　Research paper (scientific journal)

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.

Jun Matsuda, Atsushi Takahashi, Yoshitsugu Takabatake, Shinsuke Sakai, Satoshi Minami, Takeshi Yamamoto, Ryuta Fujimura, Tomoko Namba-Hamano, Hiroaki Yonishi, Jun Nakamura, Tomonori Kimura, Jun-Ya Kaimori, Isao Matsui, Masatomo Takahashi, Motonao Nakao, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Tamotsu Yoshimori, Yoshitaka Isaka

Autophagy　Vol. 16　No. 10　p. 1-16　2020/01/16　Research paper (scientific journal)

Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan.

Sumiko Ikari, Shiou-Ling Lu, Feike Hao, Kenta Imai, Yasuhiro Araki, Yo-Hei Yamamoto, Chao-Yuan Tsai, Yumi Nishiyama, Nobukazu Shitan, Tamotsu Yoshimori, Takanobu Otomo, Takeshi Noda

PloS one　Vol. 15　No. 3　2020　Research paper (scientific journal)

Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia

Akitoshi Nakashima, Shi Bin Cheng, Masahito Ikawa, Tamotsu Yoshimori, Warren J. Huber, Ramkumar Menon, Zheping Huang, Jamie Fierce, James F. Padbury, Yoel Sadovsky, Shigeru Saito, Surendra Sharma

Autophagy　Vol. 16　No. 10　p. 1-15　2019/12　Research paper (scientific journal)

Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

Deretic Vojo, Prossnitz Eric, Burge Mark, Campen Matthew J, Cannon Judy, Liu Ke Jian, Liu Meilian, Hall Pamela, Sklar Larry A, Allers Lee, Mariscal Luisa, Garcia Sally Ann, Weaver John, Baehrecke Eric H, Behrends Christian, Cecconi Francesco, Codogno Patrice, Chen Guang-Chao, Elazar Zvulun, Eskelinen Eeva-Liisa, Fourie Bernard, Gozuacik Devrim, Hong Wanjin, Jo Eun-Kyeong, Johansen Terje, Juhasz Gabor, Kimch Adi, Ktistakis Nicholas, Kroemer Guido, Mizushima Noboru, Muenz Christian, Reggiori Fulvio, Rubinsztein David, Ryan Kevin, Schroder Kate, Shen Han-Min, Simonsen Anne, Tooze Sharon A, Vaccaro Maria, Yoshimori Tamotsu, Yu Li, Zhang Hong, Klionsky Daniel J

AUTOPHAGY　Vol. 15　No. 10　p. 1829-1833　2019/10/03　Research paper (scientific journal)

Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo.

Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA

Autophagy　Vol. 15　No. 3　p. 543-557　2019/03

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes.

Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A

Nature cell biology　Vol. 21　No. 3　p. 372-383　2019/03

Suppression of autophagic activity by Rubicon is a signature of aging.

Shuhei Nakamura, Masaki Oba, Mari Suzuki, Atsushi Takahashi, Tadashi Yamamuro, Mari Fujiwara, Kensuke Ikenaka, Satoshi Minami, Namine Tabata, Kenichi Yamamoto, Sayaka Kubo, Ayaka Tokumura, Kanako Akamatsu, Yumi Miyazaki, Tsuyoshi Kawabata, Maho Hamasaki, Koji Fukui, Kazunori Sango, Yoshihisa Watanabe, Yoshitsugu Takabatake, Tomoya S Kitajima, Yukinori Okada, Hideki Mochizuki, Yoshitaka Isaka, Adam Antebi, Tamotsu Yoshimori

Nature communications　Vol. 10　No. 1　p. 847-847　2019/02/19　Research paper (scientific journal)

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.

Chunmei Chang, Lindsey N Young, Kyle L Morris, Sören von Bülow, Johannes Schöneberg, Hitomi Yamamoto-Imoto, Yukako Oe, Kentaro Yamamoto, Shuhei Nakamura, Goran Stjepanovic, Gerhard Hummer, Tamotsu Yoshimori, James H Hurley

Molecular cell　Vol. 73　No. 2　p. 339-353　2019/01/17　Research paper (scientific journal)

Induction of selective autophagy in cells replicating hepatitis C virus genome.

Hiroyuki Mori, Takasuke Fukuhara, Chikako Ono, Tomokazu Tamura, Asuka Sato, Yuzy Fauzyah, Masami Wada, Toru Okamoto, Takeshi Noda, Tamotsu Yoshimori, Yoshiharu Matsuura

The Journal of general virology　Vol. 99　No. 12　p. 1643-1657　2018/12

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.

Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH

Nature microbiology　Vol. 3　No. 12　p. 1472-1485　2018/12

Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension.

Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, Kumasawa K, Yoshimori T, Ikawa M, Saito S

The American journal of pathology　Vol. 188　No. 11　p. 2474-2486　2018/11　Research paper (scientific journal)

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.

Kie Itoh, Yoshihiro Adachi, Tatsuya Yamada, Takamichi L Suzuki, Takanobu Otomo, Heidi M McBride, Tamotsu Yoshimori, Miho Iijima, Hiromi Sesaki

The Journal of biological chemistry　Vol. 293　No. 30　p. 11809-11822　2018/07/27　Research paper (scientific journal)

Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex.

Yang F, Yang L, Wataya-Kaneda M, Hasegawa J, Yoshimori T, Tanemura A, Tsuruta D, Katayama I

Journal of dermatological science　Vol. 89　No. 2　p. 155-164　2018/02　Research paper (scientific journal)

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

Deretic Vojo, Prossnitz Eric, Burge Mark, Campen Matthew J, Cannon Judy, Liu Ke Jian, Sklar Larry A, Allers Lee, Garcia Sally Ann, Baehrecke Eric H, Behrends Christian, Cecconi Francesco, Codogno Patrice, Chen Guang-Chao, Elazar Zvulun, Eskelinen Eeva-Liisa, Fourie Bernard, Gozuacik Devrim, Hong Wanjin, Hotamisligi Gokhan, Jaaettela Marja, Jo Eun-Kyeong, Johansen Terje, Juhasz Gabor, Kimchi Adi, Ktistakis Nicholas, Kroemer Guido, MIzushima Noboru, Munz Christian, Reggiori Fulvio, Rubinsztein David, Ryan Kevin, Schroder Kate, Simonsen Anne, Tooze Sharon, Vaccaro Maria I, Yoshimori Tamotsu, Yu Li, Zhang Hong, Klionsky Daniel J

AUTOPHAGY　Vol. 14　No. 6　p. 925-929　2018

cterization of selective autophagy induced by infection with hepatitis C virus

Hiroyuki Mori, Takasuke Fukuhara, Chikako Ono, Tomokazu Tamura, Asuka Sato, Yuzy Fauzyah, Masami Wada, Toru Okamoto, Takeshi Noda, Tamotsu Yoshimori, Yoshiharu Matsuura

2017/09　Research paper (international conference proceedings)

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense

Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M. Standley, Tamotsu Yoshimori, Masahiro Yamamoto

NATURE IMMUNOLOGY　Vol. 18　No. 8　p. 899-+　2017/08　Research paper (scientific journal)

Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy

Yukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, Keiji Tanaka

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 114　No. 32　p. 8574-8579　2017/08　Research paper (scientific journal)

Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes

Shiou-Ling Lu, Tsuyoshi Kawabata, Yi-Lin Cheng, Hiroko Omori, Maho Hamasaki, Tatsuya Kusaba, Ryo Iwamoto, Hirokazu Arimoto, Takeshi Noda, Yee-Shin Lin, Tamotsu Yoshimori

PLOS PATHOGENS　Vol. 13　No. 7　2017/07　Research paper (scientific journal)

Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement.

Ikumi Hori, Takanobu Otomo, Mitsuko Nakashima, Fuyuki Miya, Yutaka Negishi, Hideaki Shiraishi, Yutaka Nonoda, Shinichi Magara, Jun Tohyama, Nobuhiko Okamoto, Takeshi Kumagai, Konomi Shimoda, Yoshiya Yukitake, Daigo Kajikawa, Tomohiro Morio, Ayako Hattori, Motoo Nakagawa, Naoki Ando, Ichizo Nishino, Mitsuhiro Kato, Tatsuhiko Tsunoda, Hirotomo Saitsu, Yonehiro Kanemura, Mami Yamasaki, Kenjiro Kosaki, Naomichi Matsumoto, Tamotsu Yoshimori, Shinji Saitoh

Scientific reports　Vol. 7　No. 1　p. 3552-3552　2017/06/14　Research paper (scientific journal)

Characterization of selective autophagy induced by HCV RNA replication

Hiroyuki Mori, Takasuke Fukuhara, Chikako Ono, Tomokazu Tamura, Kentaro Uemura, Toru Okamoto, Masami Wada, Takeshi Noda, Tamotsu Yoshimori, Yoshiharu Matsuura

2017/06　Research paper (international conference proceedings)

Intracellular fate of Ureaplasma parvum entrapped by host cellular autophagy

Fumiko Nishiumi, Michinaga Ogawa, Yukiko Nakura, Yusuke Hamada, Masahiro Nakayama, Jiro Mitobe, Atsushi Hiraide, Norio Sakai, Makoto Takeuchi, Tamotsu Yoshimori, Itaru Yanagihara

MICROBIOLOGYOPEN　Vol. 6　No. 3　2017/06　Research paper (scientific journal)

Vici症候群の臨床的および分子遺伝学的検討

堀 いくみ, 大友 孝信, 中島 光子, 宮 冬樹, 根岸 豊, 服部 文子, 安藤 直樹, 西野 一三, 角田 達彦, 才津 浩智, 小崎 健次郎, 松本 直通, 吉森 保, 齋藤 伸治

脳と発達　Vol. 49　No. Suppl.　p. S313-S313　2017/05

Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules

Atsushi Takahashi, Yoshitsugu Takabatake, Tomonori Kimura, Ikuko Maejima, Tomoko Namba, Takeshi Yamamoto, Jun Matsuda, Satoshi Minami, Jun-ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Tamotsu Yoshimori, Yoshitaka Isaka

DIABETES　Vol. 66　No. 5　p. 1359-1372　2017/05　Research paper (scientific journal)

Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis

Andree Hubber, Tomoko Kubori, Cevayir Coban, Takeshi Matsuzawa, Michinaga Ogawa, Tsuyoshi Kawabata, Tamotsu Yoshimori, Hiroki Nagai

SCIENTIFIC REPORTS　Vol. 7　2017/03　Research paper (scientific journal)

Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy-Dependent Recovery.

Takanobu Otomo, Tamotsu Yoshimori

Methods in molecular biology (Clifton, N.J.)　Vol. 1594　p. 141-149　2017

Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms.

Hidehito Kondo, Nadezda Maksimova, Takanobu Otomo, Hisakazu Kato, Atsuko Imai, Yoshihiro Asano, Kaori Kobayashi, Satoshi Nojima, Akihiro Nakaya, Yusuke Hamada, Kaori Irahara, Elizaveta Gurinova, Aitalina Sukhomyasova, Anna Nogovicina, Mira Savvina, Tamotsu Yoshimori, Keiichi Ozono, Norio Sakai

Human molecular genetics　Vol. 26　No. 1　p. 173-183　2017/01/01　Research paper (scientific journal)

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.

Satoshi Tanaka, Hayato Hikita, Tomohide Tatsumi, Ryotaro Sakamori, Yasutoshi Nozaki, Sadatsugu Sakane, Yuto Shiode, Tasuku Nakabori, Yoshinobu Saito, Naoki Hiramatsu, Keisuke Tabata, Tsuyoshi Kawabata, Maho Hamasaki, Hidetoshi Eguchi, Hiroaki Nagano, Tamotsu Yoshimori, Tetsuo Takehara

Hepatology (Baltimore, Md.)　Vol. 64　No. 6　p. 1994-2014　2016/12　Research paper (scientific journal)

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

Shun-ichi Yamashita, Xiulian Jin, Kentaro Furukawa, Maho Hamasaki, Akiko Nezu, Hidenori Otera, Tetsu Saigusa, Tamotsu Yoshimori, Yasuyoshi Sakai, Katsuyoshi Mihara, Tomotake Kanki

JOURNAL OF CELL BIOLOGY　Vol. 215　No. 5　p. 649-665　2016/12　Research paper (scientific journal)

Non-canonical LC3 lipidation induced by HCV inhibits autophagic flux

Hiroyuki Mori, Takasuke Fukuhara, Chikako Ono, Tomokazu Tamura, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masami Wada, Takeshi Noda, Tamotsu Yoshimori, Yoshiharu Matsuura

2016/10　Research paper (other academic)

Atg9A trafficking through the recycling endosomes is required for autophagosome formation

Kenta Imai, Feike Hao, Naonobu Fujita, Yasuhiro Tsuji, Yukako Oe, Yasuhiro Araki, Maho Hamasaki, Takeshi Noda, Tamotsu Yoshimori

JOURNAL OF CELL SCIENCE　Vol. 129　No. 20　p. 3781-3791　2016/10　Research paper (scientific journal)

Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome.

Junya Hasegawa, Ryo Iwamoto, Takanobu Otomo, Akiko Nezu, Maho Hamasaki, Tamotsu Yoshimori

The EMBO journal　Vol. 35　No. 17　p. 1853-67　2016/09/01

Vici症候群9例の臨床的および遺伝学的検討

堀 いくみ, 宮 冬樹, 中島 光子, 大友 孝信, 根岸 豊, 服部 文子, 安藤 直樹, 角田 達彦, 西野 一三, 金村 米博, 吉森 保, 松本 直通, 小崎 健次郎, 齋藤 伸治

脳と発達　Vol. 48　No. Suppl.　p. S261-S261　2016/05

The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity

Feike Hao, Takashi Itoh, Eiji Morita, Kanae Shirahama-Noda, Tamotsu Yoshimori, Takeshi Noda

FEBS LETTERS　Vol. 590　No. 1　p. 161-173　2016/01　Research paper (scientific journal)

Reconstitution of L-asparaginase in siliconized syringes with shaking and headspace air induces protein aggregation

Tomonobu Uchino, Yasunori Miyazaki, Tomoyo Ohkawa, Takuto Yamazaki, Yoshitsugu Yanagihara, Takayuki Yoshimori, Mamoru Komatsu, Hiroshi Suzuki, Yoshiyuki Kagawa

Chemical and Pharmaceutical Bulletin　Vol. 63　No. 10　p. 770-779　2015/10/01　Research paper (scientific journal)

HCV Infection Inhibits Autophagy through Lipidation of LC3

Takasuke Fukuhara, Masami Wada, Chikako Ono, Satomi Yamamoto, Hiroyuki Mori, Toru Okamoto, Takeshi Noda, Tamotsu Yoshimori, Yoshiharu Matsuura

2015/07　Research paper (international conference proceedings)

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

Shintaro Kira, Keisuke Tabata, Kanae Shirahama-Noda, Akiko Nozoe, Tamotsu Yoshimori, Takeshi Noda

AUTOPHAGY　Vol. 10　No. 9　p. 1565-1578　2014/09　Research paper (scientific journal)

Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy

Nayumi Shigihara, Ayako Fukunaka, Akemi Hara, Koji Komiya, Akira Honda, Toyoyoshi Uchida, Hiroko Abe, Yukiko Toyofuku, Motoyuki Tamaki, Takeshi Ogihara, Takeshi Miyatsuka, Henry J. Hiddinga, Setsuya Sakagashira, Masato Koike, Yasuo Uchiyama, Tamotsu Yoshimori, Norman L. Eberhardt, Yoshio Fujitani, Hirotaka Watada

JOURNAL OF CLINICAL INVESTIGATION　Vol. 124　No. 8　p. 3634-3644　2014/08　Research paper (scientific journal)

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

Jayoung Choi, Sunmin Park, Scott B. Biering, Elizabeth Selleck, Catherine Y. Liu, Xin Zhang, Naonobu Fujita, Tatsuya Saitoh, Shizuo Akira, Tamotsu Yoshimori, L. David Sibley, Seungmin Hwang, Herbert W. Virgin

IMMUNITY　Vol. 40　No. 6　p. 924-935　2014/06　Research paper (scientific journal)

Autophagy Induced by Calcium Phosphate Precipitates Targets Damaged Endosomes

Xi Chen, Bilon Khambu, Hao Zhang, Wentao Gao, Min Li, Xiaoyun Chen, Tamotsu Yoshimori, Xiao-Ming Yin

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 289　No. 16　p. 11162-11174　2014/04　Research paper (scientific journal)

Structural Basis of the Autophagy-Related LC3/Atg13 LIR Complex: Recognition and Interaction Mechanism

Hironori Suzuki, Keisuke Tabata, Eiji Morita, Masato Kawasaki, Ryuichi Kato, Renwick C. J. Dobson, Tamotsu Yoshimori, Soichi Wakatsuki

STRUCTURE　Vol. 22　No. 1　p. 47-58　2014/01　Research paper (scientific journal)

TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy

Kanae Shirahama-Noda, Shintaro Kira, Tamotsu Yoshimori, Takeshi Noda

JOURNAL OF CELL SCIENCE　Vol. 126　No. 21　p. 4963-4973　2013/11　Research paper (scientific journal)

Autophagy Induced by HIF1 alpha Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy

Mikiko Yamanaka-Tatematsu, Akitoshi Nakashima, Naonobu Fujita, Tomoko Shima, Tamotsu Yoshimori, Shigeru Saito

PLOS ONE　Vol. 8　No. 10　2013/10　Research paper (scientific journal)

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Haraguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, Tamotsu Yoshimori

JOURNAL OF CELL BIOLOGY　Vol. 203　No. 1　p. 115-128　2013/10　Research paper (scientific journal)

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

Yoshinobu Ichimura, Satoshi Waguri, Yu-shin Sou, Shun Kageyama, Jun Hasegawa, Ryosuke Ishimura, Tetsuya Saito, Yinjie Yang, Tsuguka Kouno, Toshiaki Fukutomi, Takayuki Hoshii, Atsushi Hirao, Kenji Takagi, Tsunehiro Mizushima, Hozumi Motohashi, Myung-Shik Lee, Tamotsu Yoshimori, Keiji Tanaka, Masayuki Yamamoto, Masaaki Komatsu

MOLECULAR CELL　Vol. 51　No. 5　p. 618-631　2013/09　Research paper (scientific journal)

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

Ikuko Maejima, Atsushi Takahashi, Hiroko Omori, Tomonori Kimura, Yoshitsugu Takabatake, Tatsuya Saitoh, Akitsugu Yamamoto, Maho Hamasaki, Takeshi Noda, Yoshitaka Isaka, Tamotsu Yoshimori

EMBO JOURNAL　Vol. 32　No. 17　p. 2336-2347　2013/08　Research paper (scientific journal)

Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

Akitoshi Nakashima, Mikiko Yamanaka-Tatematsu, Naonobu Fujita, Keiichi Koizumi, Tomoko Shima, Toshiko Yoshida, Toshio Nikaido, Aikou Okamoto, Tamotsu Yoshimori, Shigeru Saito

AUTOPHAGY　Vol. 9　No. 3　p. 303-316　2013/03　Research paper (scientific journal)

Autophagosomes form at ER-mitochondria contact sites

Maho Hamasaki, Nobumichi Furuta, Atsushi Matsuda, Akiko Nezu, Akitsugu Yamamoto, Naonobu Fujita, Hiroko Oomori, Takeshi Noda, Tokuko Haraguchi, Yasushi Hiraoka, Atsuo Amano, Tamotsu Yoshimori

NATURE　Vol. 495　No. 7441　p. 389-393　2013/03　Research paper (scientific journal)

Critical Roles for Lipomannan and Lipoarabinomannan in Cell Wall Integrity of Mycobacteria and Pathogenesis of Tuberculosis

Takeshi Fukuda, Takayuki Matsumura, Manabu Ato, Maho Hamasaki, Yukiko Nishiuchi, Yoshiko Murakami, Yusuke Maeda, Tamotsu Yoshimori, Sohkichi Matsumoto, Kazuo Kobayashi, Taroh Kinoshita, Yasu S. Morita

MBIO　Vol. 4　No. 1　p. e00472-12　2013/01　Research paper (scientific journal)

Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes

Daiki Murase, Akira Hachiya, Kei Takano, Rachel Hicks, Marty O. Visscher, Takashi Kitahara, Tadashi Hase, Yoshinori Takema, Tamotsu Yoshimori

Journal of Investigative Dermatology　Vol. 133　No. 10　p. 2416-2424　2013　Research paper (scientific journal)

Autophagy Creates a CTL Epitope That Mimics Tumor-Associated Antigens

Ayako Demachi-Okamura, Hiroki Torikai, Yoshiki Akatsuka, Hiroyuki Miyoshi, Tamotsu Yoshimori, Kiyotaka Kuzushima

PLOS ONE　Vol. 7　No. 10　2012/10　Research paper (scientific journal)

Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking

Hee Jin Kim, Qing Zhong, Zu-Hang Sheng, Tamotsu Yoshimori, Chengyu Liang, Jae U. Jung

JOURNAL OF CELL SCIENCE　Vol. 125　No. 20　p. 4740-4750　2012/10　Research paper (scientific journal)

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

Satoshi Shimizu, Tetsuo Takehara, Hayato Hikita, Takahiro Kodama, Hinako Tsunematsu, Takuya Miyagi, Atsushi Hosui, Hisashi Ishida, Tomohide Tatsumi, Tatsuya Kanto, Naoki Hiramatsu, Naonobu Fujita, Tamotsu Yoshimori, Norio Hayashi

INTERNATIONAL JOURNAL OF CANCER　Vol. 131　No. 3　p. 548-557　2012/08　Research paper (scientific journal)

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

Deepa Raju, Seamus Hussey, Michelle Ang, Mauricio R. Terebiznik, Michal Sibony, Esther Galindo-Mata, Vijay Gupta, Steven R. Blanke, Alberto Delgado, Judith Romero-Gallo, Mahendra Singh Ramjeet, Heidi Mascarenhas, Richard M. Peek, Pelayo Correa, Cathy Streutker, Georgina Hold, Erdmutte Kunstmann, Tamotsu Yoshimori, Mark S. Silverberg, Stephen E. Girardin, Dana J. Philpott, Emad El Omar, Nicola L. Jones

GASTROENTEROLOGY　Vol. 142　No. 5　p. 1160-1171　2012/05　Research paper (scientific journal)

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

Jwa-Jin Kim, Hye-Mi Lee, Dong-Min Shin, Wonho Kim, Jae-Min Yuk, Hyo Sun Jin, Sang-Hee Lee, Guang-Ho Cha, Jin-Man Kim, Zee-Won Lee, Sung Jae Shin, Heekyung Yoo, Young Kil Park, Jin Bong Park, JongKyeong Chung, Tamotsu Yoshimori, Eun-Kyeong Jo

CELL HOST & MICROBE　Vol. 11　No. 5　p. 457-468　2012/05　Research paper (scientific journal)

Bornavirus Closely Associates and Segregates with Host Chromosomes to Ensure Persistent Intranuclear Infection

Yusuke Matsumoto, Yohei Hayashi, Hiroko Omori, Tomoyuki Honda, Takuji Daito, Masayuki Horie, Kazuyoshi Ikuta, Kan Fujino, Shoko Nakamura, Urs Schneider, Geoffrey Chase, Tamotsu Yoshimori, Martin Schwemmle, Keizo Tomonaga

CELL HOST & MICROBE　Vol. 11　No. 5　p. 492-503　2012/05　Research paper (scientific journal)

Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury

Atsushi Takahashi, Tomonori Kimura, Yoshitsugu Takabatake, Tomoko Namba, Junya Kaimori, Harumi Kitamura, Isao Matsui, Fumio Niimura, Taiji Matsusaka, Naonobu Fujita, Tamotsu Yoshimori, Yoshitaka Isaka, Hiromi Rakugi

AMERICAN JOURNAL OF PATHOLOGY　Vol. 180　No. 2　p. 517-525　2012/02　Research paper (scientific journal)

Morphological analysis of autophagy

Keisuke Tabata, Mitsuko Hayashi-Nishino, Takeshi Noda, Akitsugu Yamamoto, Tamotsu Yoshimori

Methods in Molecular Biology　Vol. 931　p. 449-466　2012　Research paper (scientific journal)

Dysfunction of Autophagy Participates in Vacuole Formation and Cell Death in Cells Replicating Hepatitis C Virus

Shuhei Taguwa, Hiroto Kambara, Naonobu Fujita, Takeshi Noda, Tamotsu Yoshimori, Kazuhiko Koike, Kohji Moriishi, Yoshiharu Matsuura

JOURNAL OF VIROLOGY　Vol. 85　No. 24　p. 13185-13194　2011/12　Research paper (scientific journal)

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex

Koutaro Ishibashi, Naonobu Fujita, Eiko Kanno, Hiroko Omori, Tamotsu Yoshimori, Takashi Itoh, Mitsunori Fukuda

AUTOPHAGY　Vol. 7　No. 12　p. 1500-1513　2011/12　Research paper (scientific journal)

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

Hiroyuki Katayama, Takako Kogure, Noboru Mizushima, Tamotsu Yoshimori, Atsushi Miyawaki

CHEMISTRY & BIOLOGY　Vol. 18　No. 8　p. 1042-1052　2011/08　Research paper (scientific journal)

SPI-1 III型分泌装置はサルモネラオートファジーに重要である(SPI-1 type three secretion system is important for Salmonella xenophagy)

田中 敦史, 蔭山 俊, 西野 邦彦, 野田 健司, 吉森 保

日本細胞生物学会大会講演要旨集　Vol. 63回　p. 134-134　2011/05

Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

Ryo Tachiyama, Daisuke Ishikawa, Masaki Matsumoto, Keiichi I. Nakayama, Tamotsu Yoshimori, Sadaki Yokota, Masaru Himeno, Yoshitaka Tanaka, Hideaki Fujita

GENES TO CELLS　Vol. 16　No. 4　p. 448-466　2011/04　Research paper (scientific journal)

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

Keisuke Tabata, Kohichi Matsunaga, Ayuko Sakane, Takuya Sasaki, Takeshi Noda, Tamotsu Yoshimori

MOLECULAR BIOLOGY OF THE CELL　Vol. 21　No. 23　p. 4162-4172　2010/12　Research paper (scientific journal)

New editorial board members

Ramanujan Hegde, Thomas Langer, Danny Schnell, Tamotsu Yoshimori

Journal of Cell Biology　Vol. 190　No. 5　2010/09/06　Research paper (scientific journal)

Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages

Kevin Moreau, Sandra Lacas-Gervais, Naonobu Fujita, Florent Sebbane, Tamotsu Yoshimori, Michel Simonet, Frank Lafont

CELLULAR MICROBIOLOGY　Vol. 12　No. 8　p. 1108-1123　2010/08　Research paper (scientific journal)

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

Kohichi Matsunaga, Eiji Morita, Tatsuya Saitoh, Shizuo Akira, Nicholas T. Ktistakis, Tetsuro Izumi, Takeshi Noda, Tamotsu Yoshimori

JOURNAL OF CELL BIOLOGY　Vol. 190　No. 4　p. 511-521　2010/08　Research paper (scientific journal)

Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy

Naoko Taguchi-Atarashi, Maho Hamasaki, Kohichi Matsunaga, Hiroko Omori, Nicholas T. Ktistakis, Tamotsu Yoshimori, Takeshi Noda

TRAFFIC　Vol. 11　No. 4　p. 468-478　2010/04　Research paper (scientific journal)

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

Nobumichi Furuta, Naonobu Fujita, Takeshi Noda, Tamotsu Yoshimori, Atsuo Amano

MOLECULAR BIOLOGY OF THE CELL　Vol. 21　No. 6　p. 1001-1010　2010/03　Research paper (scientific journal)

Artificial induction of autophagy around polystyrene beads in nonphagocytic cells

Shouhei Kobayashi, Tomoko Kojidani, Hiroko Osakada, Akitsugu Yamamoto, Tamotsu Yoshimori, Yasushi Hiraoka, Tokuko Haraguchi

AUTOPHAGY　Vol. 6　No. 1　p. 36-45　2010/01　Research paper (scientific journal)

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

Mitsuko Hayashi-Nishino, Naonobu Fujita, Takeshi Noda, Akihito Yamaguchi, Tamotsu Yoshimori, Akitsugu Yamamoto

NATURE CELL BIOLOGY　Vol. 11　No. 12　p. 1433-U102　2009/12　Research paper (scientific journal)

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Tatsuya Saitoh, Naonobu Fujita, Takuya Hayashi, Keigo Takahara, Takashi Satoh, Hanna Lee, Kohichi Matsunaga, Shun Kageyama, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Taro Kawai, Ken Ishii, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 106　No. 49　p. 20842-20846　2009/12　Research paper (scientific journal)

Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy ANALYSIS OF THE ORGANIZATION OF THE Atg16L1 COMPLEX IN FIBROBLASTS

Naonobu Fujita, Tatsuya Saitoh, Shun Kageyama, Shizuo Akira, Takeshi Noda, Tamotsu Yoshimori

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 47　p. 32602-32609　2009/11　Research paper (scientific journal)

The Stent-Eluting Drugs Sirolimus and Paclitaxel Suppress Healing of the Endothelium by Induction of Autophagy

Shin-ichiro Hayashi, Akitsugu Yamamoto, Fukka You, Kentaro Yamashita, Yuka Ikegame, Masahiro Tawada, Tamotsu Yoshimori, Shigeomi Shimizu, Shigeru Nakashima

AMERICAN JOURNAL OF PATHOLOGY　Vol. 175　No. 5　p. 2226-2234　2009/11　Research paper (scientific journal)

An Initial Step of GAS-Containing Autophagosome-Like Vacuoles Formation Requires Rab7

Hitomi Yamaguchi, Ichiro Nakagawa, Akitsugu Yamamoto, Atsuo Amano, Takeshi Noda, Tamotsu Yoshimori

PLOS PATHOGENS　Vol. 5　No. 11　2009/11　Research paper (scientific journal)

Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments

Nobumichi Furuta, Kayoko Tsuda, Hiroko Omori, Tamotsu Yoshimori, Fuminobu Yoshimura, Atsuo Amano

INFECTION AND IMMUNITY　Vol. 77　No. 10　p. 4187-4196　2009/10　Research paper (scientific journal)

Cochaperone Activity of Human Butyrate-Induced Transcript 1 Facilitates Hepatitis C Virus Replication through an Hsp90-Dependent Pathway

Shuhei Taguwa, Hiroto Kambara, Hiroko Omori, Hideki Tani, Takayuki Abe, Yoshio Mori, Tetsuro Suzuki, Tamotsu Yoshimori, Kohji Moriishi, Yoshiharu Matsuura

JOURNAL OF VIROLOGY　Vol. 83　No. 20　p. 10427-10436　2009/10　Research paper (scientific journal)

Autophagy and the Endoplasmic Reticulum

M. Hayashi-Nishino, N. Fujita, T. Noda, A. Yamaguchi, T. Yoshimori, A. Yamamoto

2009/09

[Regulation of inflammation by autophagy].

Saitoh T, Naonobu F, Yoshimori T, Akira S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 54　No. 8 Suppl　p. 1119-1124　2009/06　Research paper (scientific journal)

Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection

Yoshihito Ishida, Akitsugu Yamamoto, Akira Kitamura, Shireen R. Lamande, Tamotsu Yoshimori, John F. Bateman, Hiroshi Kubota, Kazuhiro Nagata

MOLECULAR BIOLOGY OF THE CELL　Vol. 20　No. 11　p. 2744-2754　2009/06　Research paper (scientific journal)

電子線トモグラフィーにより見いだされた、オートファゴソームを形成する"ゆりかご"としての小胞体サブドメイン(Electron Tomography Revealed a Subdomain of the Endoplasmic Reticulum as a Cradle for Autophagosome Formation)

西野 美都子[林], 藤田 尚信, 野田 健司, 山口 明人, 吉森 保, 山本 章嗣

日本細胞生物学会大会講演要旨集　Vol. 61回　p. 174-174　2009/05

Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells

Mauricio R. Terebiznik, Deepa Raju, Cristina L. Vazquez, Karl Torbricki, Reshma Kulkarni, Steven R. Blanke, Tamotsu Yoshimori, Maria I. Colombo, Nicola L. Jones

AUTOPHAGY　Vol. 5　No. 3　p. 370-379　2009/04　Research paper (scientific journal)

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

Kohichi Matsunaga, Tatsuya Saitoh, Keisuke Tabata, Hiroko Omori, Takashi Satoh, Naoki Kurotori, Ikuko Maejima, Kanae Shirahama-Noda, Tohru Ichimura, Toshiaki Isobe, Shizuo Akira, Takeshi Noda, Tamotsu Yoshimori

NATURE CELL BIOLOGY　Vol. 11　No. 4　p. 385-U69　2009/04　Research paper (scientific journal)

Group A Streptococcus: A Loser in the Battle with Autophagy

Tamotsu Yoshimori, Atsuo Amano

AUTOPHAGY IN INFECTION AND IMMUNITY　Vol. 335　p. 217-226　2009　Part of collection (book)

Binding Rubicon to cross the RubiconAutophagy

Kohichi Matsunaga, Takeshi Noda, Tamotsu Yoshimori

Autophagy　Vol. 5　No. 6　p. 876-877　2009

MONITORING AUTOPHAGY IN MAMMALIAN CULTURED CELLS THROUGH THE DYNAMICS OF LC3

Shunsuke Kimura, Naonobu Fujita, Takeshi Noda, Tamotsu Yoshimori

METHODS IN ENZYMOLOGY: AUTOPHAGY IN MAMMALIAN SYSTEMS, VOL 452, PT B　Vol. 452　p. 1-12　2009　Part of collection (book)

Atg4B(C74A) hampers autophagosome closure A useful protein for inhibiting autophagy

Naonobu Fujita, Takeshi Noda, Tamotsu Yoshimori

AUTOPHAGY　Vol. 5　No. 1　p. 88-89　2009/01　Research paper (scientific journal)

The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy

Shin-Ichiro Hayashi, Akitsugu Yamamoto, Fukka You, Kentaro Yamashita, Yuka Ikegame, Masahiro Tawada, Tamotsu Yoshimori, Shigeomi Shimizu, Shigeru Nakashima

American Journal of Pathology　Vol. 175　No. 5　p. 2226-2234　2009　Research paper (scientific journal)

[Autophagy and innate immunity].

Saitoh T, Fujita N, Yoshimori T, Akira S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 53　No. 16 Suppl　p. 2279-2285　2008/12　Research paper (scientific journal)

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death

D. Gozuacik, S. Bialik, T. Raveh, G. Mitou, G. Shohat, H. Sabanay, N. Mizushima, T. Yoshimori, A. Kimchi

CELL DEATH AND DIFFERENTIATION　Vol. 15　No. 12　p. 1875-1886　2008/12　Research paper (scientific journal)

Nucleotide-Dependent Conformational Changes and Assembly of the AAA ATPase SKD1/VPS4B

Michio Inoue, Hironari Kamikubo, Mikio Kataoka, Ryuichi Kato, Tamotsu Yoshimori, Soichi Wakatsuki, Masato Kawasaki

TRAFFIC　Vol. 9　No. 12　p. 2180-2189　2008/12　Research paper (scientific journal)

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

Naonobu Fujita, Mitsuko Hayashi-Nishino, Hiromi Fukumoto, Hiroko Omori, Akitsugu Yamamoto, Takeshi Noda, Tamotsu Yoshimori

MOLECULAR BIOLOGY OF THE CELL　Vol. 19　No. 11　p. 4651-4659　2008/11　Research paper (scientific journal)

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 beta production

Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo-Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira

NATURE　Vol. 456　No. 7219　p. 264-U68　2008/11　Research paper (scientific journal)

オートファジーを制御するシグナル伝達経路

野田健司, 吉森 保

実験医学増刊号　2008/09

Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation

Kyohei Umebayashi, Harald Stenmark, Tamotsu Yoshimori

MOLECULAR BIOLOGY OF THE CELL　Vol. 19　No. 8　p. 3454-3462　2008/08　Research paper (scientific journal)

Autophagic control of listeria through intracellular innate immune recognition in drosophila

Tamaki Yano, Shizuka Mita, Hiroko Ohmori, Yoshiteru Oshima, Yukari Fujimoto, Ryu Ueda, Haruhiko Takada, William E. Goldman, Koichi Fukase, Neal Silverman, Tamotsu Yoshimori, Shoichiro Kurata

NATURE IMMUNOLOGY　Vol. 9　No. 8　p. 908-916　2008/08　Research paper (scientific journal)

Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation

Takashi Itoh, Naonobu Fujita, Eiko Kanno, Akitsugu Yamamoto, Tamotsu Yoshimori, Mitsunori Fukuda

MOLECULAR BIOLOGY OF THE CELL　Vol. 19　No. 7　p. 2916-2925　2008/07　Research paper (scientific journal)

Atg4B変異体によるLC3システム障害は、オートファゴソームの取り込み異常により引き起こされる(Hampering LC3 System by the Atg4B Mutant Causes Defect in Enclosure of Autophagosome)

藤田 尚信, 林 美都子, 山本 章嗣, 野田 健司, 吉森 保

日本細胞生物学会大会講演要旨集　Vol. 60回　p. 162-162　2008/06

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

Naonobu Fujita, Takashi Itoh, Hiroko Omori, Mitsunori Fukuda, Takeshi Noda, Tamotsu Yoshimori

MOLECULAR BIOLOGY OF THE CELL　Vol. 19　No. 5　p. 2092-2100　2008/05　Research paper (scientific journal)

A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication

Toru Okamoto, Hiroko Omori, Yuuki Kaname, Takayuki Abe, Yorihiro Nishimura, Tetsuro Suzuki, Tatsuo Miyamura, Tamotsu Yoshimori, Kohji Moriishi, Yoshiharu Matsuura

JOURNAL OF VIROLOGY　Vol. 82　No. 7　p. 3480-3489　2008/04　Research paper (scientific journal)

哺乳類オートファジーを実行する分子機構

野田健司, 吉森 保

実験医学増刊号“細胞内の輪廻転生 タンパク質の分解機構”　2008/01

Human RME-8 Is Involved in Membrane Trafficking through Early Endosomes

Akemi Fujibayashi, Tomohiko Taguchi, Ryo Misaki, Masashi Ohtani, Naoshi Dohmae, Koji Takio, Masashi Yamada, Jianguo Gu, Megumi Yamakami, Mitsunori Fukuda, Satoshi Waguri, Yasuo Uchiyama, Tamotsu Yoshimori, Kiyotoshi Sekiguchi

CELL STRUCTURE AND FUNCTION　Vol. 33　No. 1　p. 35-50　2008　Research paper (scientific journal)

GFP-like proteins stably accumulate in lysosomes

Hiroyuki Katayama, Akitsugu Yamamoto, Noboru Mizushima, Tamotsu Yoshimori, Atsushi Miyawaki

CELL STRUCTURE AND FUNCTION　Vol. 33　No. 1　p. 1-12　2008　Research paper (scientific journal)

Functional Analysis of alpha 5 beta 1 Integrin and Lipid Rafts in Invasion of Epithelial Cells by Porphyromonas gingivalis using Fluorescent Beads Coated with Bacterial Membrane Vesicles

Kayoko Tsuda, Nobumichi Furuta, Hiroaki Inaba, Shinji Kawai, Kentaro Hanada, Tamotsu Yoshimori, Atsuo Amano

CELL STRUCTURE AND FUNCTION　Vol. 33　No. 1　p. 123-132　2008　Research paper (scientific journal)

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

Shunsuke Kimura, Takeshi Noda, Tamotsu Yoshimori

CELL STRUCTURE AND FUNCTION　Vol. 33　No. 1　p. 109-122　2008　Research paper (scientific journal)

The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing

Satoshi Uematsu, Tsuneyasu Kaisho, Takashi Tanaka, Makoto Matsumoto, Megumi Yamakami, Hiroko Omori, Masahiro Yamamoto, Tamotsu Yoshimori, Shizuo Akira

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 8　p. 5378-5386　2007/10　Research paper (scientific journal)

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

Shunsuke Kimura, Takeshi Noda, Tamotsu Yoshimori

AUTOPHAGY　Vol. 3　No. 5　p. 452-460　2007/09　Research paper (scientific journal)

Listeria monocytogenes evades killing by autophagy during colonization of host cells

Cheryl L. Birmingham, Veronica Canadieni, Edith Gouin, Erin B. Troy, Tamotsu Yoshimori, Pascale Cossart, Darren E. Higgins, John H. Brumell

AUTOPHAGY　Vol. 3　No. 5　p. 442-451　2007/09　Research paper (scientific journal)

Role of Hrs in maturation of autophagosomes in mammalian cells

Keiichi Tamai, Nobuyuki Tanaka, Atsuki Nara, Akitsugu Yamamoto, Ichiro Nakagawa, Tamotsu Yoshimori, Yoshiyuki Ueno, Tooru Shimosegawa, Kazuo Sugamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 360　No. 4　p. 721-727　2007/09　Research paper (scientific journal)

Maturation of fimbria precursor protein by exogenous gingipains in Porphyromonas gingivalis gingipain-null mutant

Takahiro Kato, Tetsuhisa Tsuda, Hiroko Omori, Takafumi Kato, Tamotsu Yoshimori, Atsuo Amano

FEMS MICROBIOLOGY LETTERS　Vol. 273　No. 1　p. 96-102　2007/08　Research paper (scientific journal)

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

Wen-Xing Ding, Hong-Min Ni, Wentao Gao, Tamotsu Yoshimori, Donna B. Stolz, David Ron, Xiao-Ming Yin

AMERICAN JOURNAL OF PATHOLOGY　Vol. 171　No. 2　p. 513-524　2007/08　Research paper (scientific journal)

The anticancer drug imatinib induces cellular autophagy

A. Ertmer, V. Huber, S. Gilch, T. Yoshimori, V. Erfle, J. Duyster, H-P Elsaesser, H. M. Schaetzl

LEUKEMIA　Vol. 21　No. 5　p. 936-942　2007/05　Research paper (scientific journal)

Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype

Takahiro Kato, Shinji Kawai, Kazuhiko Nakano, Hiroaki Inaba, Masae Kuboniwa, Ichiro Nakagawa, Kayoko Tsuda, Hiroko Omori, Takashi Ooshima, Tamotsu Yoshimori, Atsuo Amano

CELLULAR MICROBIOLOGY　Vol. 9　No. 3　p. 753-765　2007/03　Research paper (scientific journal)

Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells

Kohei Arasaki, Katsuko Tani, Tamotsu Yoshimori, David J. Stephens, Mitsuo Tagaya

MOLECULAR PHARMACOLOGY　Vol. 71　No. 2　p. 454-460　2007/02　Research paper (scientific journal)

Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V-cholerae

Maximiliano Gabriel Gutierrez, Hector Alex Saka, Isabel Chinen, Felipe C. M. Zoppino, Tamotsu Yoshimori, Jose Luis Bocco, Maria Isabel Colombo

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 6　p. 1829-1834　2007/02　Research paper (scientific journal)

Autophagy Eliminates Group A Streptococcus Invading Host Cells

Atsuo Amano, Tamotsu Yoshimori

Autophagy in Immunity and Infection: A Novel Immune Effector　p. 139-150　2006/08/28　Part of collection (book)

Host defense mechanism by autophagy.

Nakagawa I, Yoshimori T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 51　No. 10 Suppl　p. 1507-1514　2006/08

[Autophagic degradation of unfolding proteins].

Kimura S, Kamimoto T, Yoshimori T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 51　p. 1494-1498　2006/08

Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4

Y Ohsaki, Y Sugimoto, M Suzuki, H Hosokawa, T Yoshimori, JP Davies, YA Ioannou, MT Vanier, K Ohno, H Ninomiya

JOURNAL OF CELL SCIENCE　Vol. 119　No. 13　p. 2643-2653　2006/07　Research paper (scientific journal)

ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy

Jason Szeto, Natalia A. Kaniuk, Veronica Canadien, Rozalia Nisman, Noboru Mizushima, Tamotsu Yoshimori, David P. Bazett-Jones, John H. Brumell

AUTOPHAGY　Vol. 2　No. 3　p. 189-199　2006/07　Research paper (scientific journal)

Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms

Z. Berkova, S. E. Crawford, G. Trugnan, T. Yoshimori, A. P. Morris, M. K. Estes

JOURNAL OF VIROLOGY　Vol. 80　No. 12　p. 6061-6071　2006/06　Research paper (scientific journal)

Survival of parvovirus B19-infected cells by cellular autophagy

A Nakashima, N Tanaka, K Tamai, M Kyuuma, Y Ishikawa, H Sato, T Yoshimori, S Saito, K Sugamura

VIROLOGY　Vol. 349　No. 2　p. 254-263　2006/06　Research paper (scientific journal)

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1

Mamoru Shibata, Tao Lu, Tsuyoshi Furuya, Alexei Degterev, Noboru Mizushima, Tamotsu Yoshimori, Marcy MacDonald, Bruce Yankner, Junying Yuan

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 20　p. 14474-14485　2006/05　Research paper (scientific journal)

Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole

CL Birmingham, AC Smith, MA Bakowski, T Yoshimori, JH Brumell

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 16　p. 11374-11383　2006/04　Research paper (scientific journal)

CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis

JH Shim, CC Xiao, MS Hayden, KY Lee, ES Trombetta, M Pypaert, A Nara, T Yoshimori, B Wilm, H Erdjument-Bromage, P Tempst, BLM Hogan, Mellman, I, S Ghosh

JOURNAL OF CELL BIOLOGY　Vol. 172　No. 7　p. 1045-1056　2006/03　Research paper (scientific journal)

Intracellular inclusions containing mutant alpha(1)-antitrypsin Z are propagated in the absence of autophagic activity

T Kamimoto, S Shoji, T Hidvegi, N Mizushima, K Umebayashi, DH Perlmutter, T Yoshimori

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 7　p. 4467-4476　2006/02　Research paper (scientific journal)

Induced expressions of Rab24 GTPase and LC3 in nerve-injured motor neurons

Y Egami, S Kiryu-Seo, T Yoshimori, H Kiyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 337　No. 4　p. 1206-1213　2005/12　Research paper (scientific journal)

Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle

K Tsuda, A Amano, K Umebayashi, H Inaba, Nakagawa, I, Y Nakanishi, T Yoshimori

CELL STRUCTURE AND FUNCTION　Vol. 30　No. 1-2　p. 81-91　2005/12　Research paper (scientific journal)

Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes

E Mizuno, T Iura, A Mukai, T Yoshimori, N Kitamura, M Komada

MOLECULAR BIOLOGY OF THE CELL　Vol. 16　No. 11　p. 5163-5174　2005/11　Research paper (scientific journal)

Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitochondria in SY5Y cells

R Towns, Y Kabeya, T Yoshimori, CF Guo, Y Shangguan, S Hong, M Kaplan, DJ Klionsky, JW Wiley

AUTOPHAGY　Vol. 1　No. 3　p. 163-170　2005/10　Research paper (scientific journal)

Involvement of autophagy in neurodegneration and axonal degeneration in lurcher mice

Takahiro Kamimoto, Shisako Shoji, Noboru Mizushima, Kyohei Umebayashi, Tunda Hidvegi, David Perlmutter, Tamotsu Yoshimori

CELL STRUCTURE AND FUNCTION　Vol. 30　p. 18-18　2005/06

Small GTPase proteins Rin and Rit bind to PAR6 GTP-dependently and regulate cell transformation

M Hoshino, T Yoshimori, S Nakamura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 24　p. 22868-22874　2005/06　Research paper (scientific journal)

Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast

T Yamada, AR Carson, Caniggia, I, K Umebayashi, T Yoshimori, K Nakabayashi, SW Scherer

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 280　No. 18　p. 18283-18290　2005/05　Research paper (scientific journal)

Escape of intracellular Shigella from autophagy

M Ogawa, T Yoshimori, T Suzuki, H Sagara, N Mizushima, C Sasakawa

SCIENCE　Vol. 307　No. 5710　p. 727-731　2005/02　Research paper (scientific journal)

Inhibition of macroautophagy triggers apoptosis

P Boya, RA Gonzalez-Polo, N Casares, JL Perfettini, P Dessen, N Larochette, D Metivier, D Meley, S Souquere, T Yoshimori, G Pierron, P Codogno, G Kroemer

MOLECULAR AND CELLULAR BIOLOGY　Vol. 25　No. 3　p. 1025-1040　2005/02　Research paper (scientific journal)

The role of autophagy during the early neonatal starvation period

A Kuma, M Hatano, M Matsui, A Yamamoto, H Nakaya, T Yoshimori, Y Ohsumi, T Tokuhisa, N Mizushima

NATURE　Vol. 432　No. 7020　p. 1032-1036　2004/12　Research paper (scientific journal)

Autophagy defends cells against invading group a Streptococcus

Nakagawa, I, A Amano, N Mizushima, A Yamamoto, H Yamaguchi, T Kamimoto, J Nara, J Funao, M Nakata, K Tsuda, S Hamada, T Yoshimori

SCIENCE　Vol. 306　No. 5698　p. 1037-1040　2004/11　Research paper (scientific journal)

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

A Simonsen, HCG Birkeland, DJ Gillooly, N Mizushima, A Kuma, T Yoshimori, T Slagsvold, A Brech, H Stenmark

JOURNAL OF CELL SCIENCE　Vol. 117　No. 18　p. 4239-4251　2004/08　Research paper (scientific journal)

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Y Kabeya, N Mizushima, A Yamamoto, S Oshitani-Okamoto, Y Ohsumi, T Yoshimori

JOURNAL OF CELL SCIENCE　Vol. 117　No. 13　p. 2805-2812　2004/06　Research paper (scientific journal)

Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Nps4B

H Fujita, Y Umezuki, K Imamura, D Ishikawa, S Uchimura, A Nara, T Yoshimori, Y Hayashizaki, J Kawa, K Ishidoh, Y Tanaka, M Himeno

JOURNAL OF CELL SCIENCE　Vol. 117　No. 14　p. 2997-3009　2004/06　Research paper (scientific journal)

The significance of the dual localization of Nsdhl between lipid droplets and the endoplasmic reticulum

O. Masato Ohashi, Noboru Mizushima, Yukiko Kabeya, Tamotsu Yoshimori

CELL STRUCTURE AND FUNCTION　Vol. 29　p. 103-103　2004/05

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

N Mizushima, A Yamamoto, M Matsui, T Yoshimori, Y Ohsumi

MOLECULAR BIOLOGY OF THE CELL　Vol. 15　No. 3　p. 1101-1111　2004/03　Research paper (scientific journal)

Coronavirus replication complex formation utilizes components of cellular autophagy

E Prentice, WG Jerome, T Yoshimori, N Mizushima, MR Denison

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 279　No. 11　p. 10136-10141　2004/03　Research paper (scientific journal)

Insulin-dependent signaling regulates azurophil granule-selective macroautophagy in human myeloblastic cells

K Saeki, Z Hong, M Nakatsu, T Yoshimori, Y Kabeya, A Yamamoto, Y Kaburagi, A Yuo

JOURNAL OF LEUKOCYTE BIOLOGY　Vol. 74　No. 6　p. 1108-1116　2003/12　Research paper (scientific journal)

Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin

M Yamakami, T Yoshimori, H Yokosawa

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 52　p. 52865-52872　2003/12　Research paper (scientific journal)

Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation

C Kanazawa, E Morita, M Yamada, N Ishii, S Miura, H Asao, T Yoshimori, K Sugamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 309　No. 4　p. 848-856　2003/10　Research paper (scientific journal)

The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting

K Katoh, H Shibata, H Suzuki, A Nara, K Ishidoh, E Kominami, T Yoshimori, M Maki

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 40　p. 39104-39113　2003/10　Research paper (scientific journal)

Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets

M Ohashi, N Mizushima, Y Kabeya, T Yoshimori

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 278　No. 38　p. 36819-36829　2003/09　Research paper (scientific journal)

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

N Mizushima, A Kuma, Y Kobayashi, A Yamamoto, M Matsubae, T Takao, T Natsume, Y Ohsumi, T Yoshimori

JOURNAL OF CELL SCIENCE　Vol. 116　No. 9　p. 1679-1688　2003/05　Research paper (scientific journal)

A dominant negative form of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of endosomal/lysosomal compartments: class E vps phenotype in mammalian cells

H Fujita, M Yamanaka, K Imamura, Y Tanaka, A Nara, T Yoshimori, S Yokota, M Himeno

JOURNAL OF CELL SCIENCE　Vol. 116　No. 2　p. 401-414　2003/01　Research paper (scientific journal)

Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method

N Mizushima, T Yoshimori, Y Ohsumi

FEBS LETTERS　Vol. 532　No. 3　p. 450-454　2002/12　Research paper (scientific journal)

PIKfyve kinase and SKD1 AAA ATPase define distinct endocytic compartments - Only PIKfyve expression inhibits the cell-vacuolating activity of Helicobacter pylori VacA toxin

OC Ikonomov, D Sbrissa, T Yoshimori, TL Cover, A Shisheva

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 48　p. 46785-46790　2002/11　Research paper (scientific journal)

The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy

T Suzuki, M Nakagawa, A Yoshikawa, N Sasagawa, T Yoshimori, Y Ohsumi, Nishino, I, S Ishiura, Nonaka, I

JOURNAL OF BIOCHEMISTRY　Vol. 131　No. 5　p. 647-651　2002/05　Research paper (scientific journal)

SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation

A Nara, N Mizushima, A Yamamoto, Y Kabeya, Y Ohsumi, T Yoshimori

CELL STRUCTURE AND FUNCTION　Vol. 27　No. 1　p. 29-37　2002/02　Research paper (scientific journal)

Autophagy in mammaliancells - Enter Actors

T Yoshimori

SEIKAGAKU　Vol. 73　No. 9　p. 1154-1159　2001/09　Research paper (scientific journal)

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

N Mizushima, A Yamamoto, M Hatano, Y Kobayashi, Y Kabeya, K Suzuki, T Tokuhisa, Y Ohsumi, T Yoshimori

JOURNAL OF CELL BIOLOGY　Vol. 152　No. 4　p. 657-667　2001/02　Research paper (scientific journal)

Autophagosome requires specific early sec proteins for its formation and NSF/SNARE for vacuolar fusion

N. Ishihara, M. Hamasaki, S. Yokota, K. Suzuki, Y. Kamada, A. Kihara, T. Yoshimori, T. Noda, Y. Ohsumi

Molecular Biology of the Cell　Vol. 12　No. 11　p. 3690-3702　2001　Research paper (scientific journal)

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

A. Kihara, Y. Kabeya, Y. Ohsumi, T. Yoshimori

EMBO Reports　Vol. 2　No. 4　p. 330-335　2001　Research paper (scientific journal)

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Y Kabeya, N Mizushima, T Uero, A Yamamoto, T Kirisako, T Noda, E Kominami, Y Ohsumi, T Yoshimori

EMBO JOURNAL　Vol. 19　No. 21　p. 5720-5728　2000/11　Research paper (scientific journal)

The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

T Kirisako, Y Ichimura, H Okada, Y Kabeya, N Mizushima, T Yoshimori, M Ohsumi, T Takao, T Noda, Y Ohsumi

JOURNAL OF CELL BIOLOGY　Vol. 151　No. 2　p. 263-275　2000/10　Research paper (scientific journal)

Immunohistochemical localization of V-ATPases in rat spermatids

G Kawa, A Yamamoto, T Yoshimori, K Muguruma, T Matsuda, Y Moriyama

INTERNATIONAL JOURNAL OF ANDROLOGY　Vol. 23　No. 5　p. 278-283　2000/10　Research paper (scientific journal)

Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells

M Tabuchi, T Yoshimori, K Yamaguchi, T Yoshida, F Kishi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 29　p. 22220-22228　2000/07　Research paper (scientific journal)

The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells

Tamotsu Yoshimori, Fumi Yamagata, Akitsugu Yamamoto, Noboru Mizushima, Yukiko Kabeya, Atsuki Nara, Ishido Miwako, Masato Ohashi, Mariko Ohsumi, Yoshinori Ohsumi

Molecular Biology of the Cell　Vol. 11　No. 2　p. 747-763　2000　Research paper (scientific journal)

The Apg12 conjugation system essential for autophagy.

N Mizushima, T Shintani, T Noda, T Yoshimori, M Ohsumi, Y Ohsumi

MOLECULAR BIOLOGY OF THE CELL　Vol. 10　p. 232A-232A　1999/11　Research paper (international conference proceedings)

Formation process of autophagosome is traced with Apg8/Aut7p in yeast

Takayoshi Kirisako, Misuzu Baba, Naotada Ishihara, Kouichi Miyazawa, Mariko Ohsumi, Tamotsu Yoshimori, Takeshi Noda, Yoshinori Ohsumi

Journal of Cell Biology　Vol. 147　No. 2　p. 435-446　1999　Research paper (scientific journal)

A 60 kDa plasma membrane protein changes its localization to autophagosome and autolysosome membranes during induction of autophagy in rat hepatoma cell line, H-4-II-E cells

Yoshihiro Tagawa, Akitsugu Yamamoto, Tamotsu Yoshimori, Ryuichi Masaki, Koichiro Omori, Masaru Himeno, Kyoichi Inoue, Yutaka Tashiro

Cell Structure and Function　Vol. 24　No. 2　p. 59-70　1999　Research paper (scientific journal)

A new protein conjugation system in human - The counterpart of the yeast Apg12p conjugation system essential for autophagy

N Mizushima, H Sugita, T Yoshimori, Y Ohsumi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 273　No. 51　p. 33889-33892　1998/12　Research paper (scientific journal)

A protein conjugation system essential for autophagy

N Mizushima, T Noda, T Yoshimori, Y Tanaka, T Ishii, MD George, DJ Klionsky, M Ohsumi, Y Ohsumi

NATURE　Vol. 395　No. 6700　p. 395-398　1998/09　Research paper (scientific journal)

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Akitsugu Yamamoto, Yoshihiro Tagawa, Tamotsu Yoshimori, Yoshinori Moriyama, Ryuichi Masaki, Yutaka Tashiro

Cell Structure and Function　Vol. 23　No. 1　p. 33-42　1998　Research paper (scientific journal)

Sorting in the TGN into different transport routes to the plasma membrane in fibroblasts

T. Yoshimori

Seikagaku　Vol. 69　No. 6　p. 410-416　1997　Research paper (scientific journal)

Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells

T Yoshimori, P Keller, MG Roth, K Simons

JOURNAL OF CELL BIOLOGY　Vol. 133　No. 2　p. 247-256　1996/04　Research paper (scientific journal)

Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid

Mitsuo Tagaya, Nobuhiro Henomatsu, Tamotsu Yoshimori, Akitsugu Yamamoto, Yutaka Tashiro, Shoji Mizushima

Journal of Biochemistry　Vol. 119　No. 5　p. 863-869　1996　Research paper (scientific journal)

Expression and Phosphorylation of BIP/GRP78, a Molecular Chaperone in the Endoplasmic Reticulum, During the Differentiation of a Mouse Myeloblastic Cell Line

Akira Nakai, Mamoru Satoh, Kazuhiro Nagata, Akira Nakai, Toshio Kawatani, Shinji Ohi, Hironaka Kawasaki, Tamotsu Yoshimori, Yutaka Tashiro, Yoshihiko Miyata, Ichiro Yahara

Cell Structure and Function　Vol. 20　No. 1　p. 33-39　1995　Research paper (scientific journal)

PROTEIN DISULFIDE-ISOMERASE ASSOCIATES WITH MISFOLDED HUMAN LYSOZYME IN-VIVO

M OTSU, F OMURA, T YOSHIMORI, M KIKUCHI

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 269　No. 9　p. 6874-6877　1994/03　Research paper (scientific journal)

ATP-dependent uptake of anti-neoplastic agents by acidic organelles

Yoshinori Moriyama, Tsukasa Manabe, Tamotsu Yoshimori, Yutaka Tashiro, Masamitsu Futai

Journal of Biochemistry　Vol. 115　No. 2　p. 213-218　1994　Research paper (scientific journal)

Preferential localization of heat shock protein 47 in dilated endoplasmic reticulum of chicken chondrocytes

K. Kambe, A. Yamamoto, T. Yoshimori, K. Hirayoshi, R. Ogawa, Y. Tashiro

Journal of Histochemistry and Cytochemistry　Vol. 42　No. 7　p. 833-841　1994　Research paper (scientific journal)

Acidification of phagosomes and degradation of rod outer segments in rat retinal pigment epithelium

J. Deguchi, A. Yamamoto, T. Yoshimori, K. Sugasawa, Y. Moriyama, M. Futai, T. Suzuki, K. Kato, M. Uyama, Y. Tashiro

Investigative Ophthalmology and Visual Science　Vol. 35　No. 2　p. 568-579　1994　Research paper (scientific journal)

CORRELATION BETWEEN PHOSPHOLIPASE-A2 ACTIVITY AND INTRA-GOLGI PROTEIN-TRANSPORT RECONSTITUTED IN A CELL-FREE SYSTEM

M TAGAYA, N HENOMATSU, T YOSHIMORI, A YAMAMOTO, Y TASHIRO, T FUKUI

FEBS LETTERS　Vol. 324　No. 2　p. 201-204　1993/06　Research paper (scientific journal)

Inhibitors of vacuolar‐type H+‐ATPase suppresses proliferation of cultured cells

Tsukasa Manabe, Tamotsu Yoshimori, Nobuhiro Henomatsu, Yutaka Tashiro

Journal of Cellular Physiology　Vol. 157　No. 3　p. 445-452　1993　Research paper (scientific journal)

Inhibition of intracellular transport of newly synthesized prolactin by bafilomycin A1 in a pituitary tumor cell line, GH3 cells

N. Henomatsu, T. Yoshimori, A. Yamamoto, Y. Moriyama, Y. Tashiro

European Journal of Cell Biology　Vol. 62　No. 1　p. 127-139　1993　Research paper (scientific journal)

Non‐lysosomal degradation of misfolded human lysozymes with and without an asparagine‐linked glycosylation site

Fumihiko OMURA, Mieko OTSU, Tamotsu YOSHIMORI, Yutaka TASHIRO, Masakazu KIKUCHI

European Journal of Biochemistry　Vol. 210　No. 2　p. 591-599　1992　Research paper (scientific journal)

Heavy chain binding protein (BiP/GRP78) and endoplasmin are exported from the endoplasmic reticulum in rat exocrine pancreatic cells, similar to protein disulfide-isomerase

Hiroto Takemoto, Tamotsu Yoshimori, Akitsugu Yamamoto, Yoshihiko Miyata, Ichiro Yahara, Kyoichi Inoue, Yutaka Tashiro

Archives of Biochemistry and Biophysics　Vol. 296　No. 1　p. 129-136　1992　Research paper (scientific journal)

BAFILOMYCIN-A1, A SPECIFIC INHIBITOR OF VACUOLAR-TYPE H+-ATPASE, INHIBITS ACIDIFICATION AND PROTEIN-DEGRADATION IN LYSOSOMES OF CULTURED-CELLS

T YOSHIMORI, A YAMAMOTO, Y MORIYAMA, M FUTAI, Y TASHIRO

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 266　No. 26　p. 17707-17712　1991/09　Research paper (scientific journal)

EXPRESSION, LOCALIZATION, AND FUNCTION OF AN N-TERMINAL HALF FRAGMENT OF THE RAT NA,K-ATPASE BETA-SUBUNIT IN HELA-CELLS

K OMORI, K OMORI, T MORIMOTO, T TAKADA, M AKAYAMA, T YOSHIMORI, DD SABATINI, Y TASHIRO

JOURNAL OF BIOCHEMISTRY　Vol. 109　No. 2　p. 267-275　1991/02　Research paper (scientific journal)

Stacks of Flattened Smooth Endoplasmic Reticulum Highly Enriched in Inositol 1,4,5-Trisphosphate (InsP3) Receptor in Mouse Cerebellar Purkinje Cells

Akitsugu Yamamoto, Tamotsu Yoshimori, Yutaka Tashiro, Hiroko Otsu, Nobuaki Maeda, Katsuhiko Mikoshiba

Cell Structure and Function　Vol. 16　No. 5　p. 419-432　1991　Research paper (scientific journal)

PROTEIN DISULFIDE-ISOMERASE IN RAT EXOCRINE PANCREATIC-CELLS IS EXPORTED FROM THE ENDOPLASMIC-RETICULUM DESPITE POSSESSING THE RETENTION SIGNAL

T YOSHIMORI, T SEMBA, H TAKEMOTO, S AKAGI, A YAMAMOTO, Y TASHIRO

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 265　No. 26　p. 15984-15990　1990/09　Research paper (scientific journal)

INTRACELLULAR-TRANSPORT BETWEEN ENDOPLASMIC-RETICULUM AND GOLGI-APPARATUS

Y TASHIRO, S AKAGI, T YOSHIMORI, A YAMAMOTO

CELL BIOLOGY OF SECRETION　Vol. 26　p. 25-36　1989　Research paper (international conference proceedings)

Distribution of protein disulfide isomerase in rat epiphyseal chondrocytes

S. Akagi, A. Yamamoto, T. Yoshimori, R. Masaki, R. Ogawa, Y. Tashiro

Journal of Histochemistry and Cytochemistry　Vol. 37　No. 12　p. 1835-1844　1989　Research paper (scientific journal)

Distribution of protein disulfide isomerase in rat hepatocytes

S. Akagi, A. Yamamoto, T. Yoshimori, R. Masaki, R. Ogawa, Y. Tashiro

Journal of Histochemistry and Cytochemistry　Vol. 36　No. 12　p. 1533-1542　1988　Research paper (scientific journal)

Localization of protein disulfide isomerase on plasma membranes of rat exocrine pancreatic cells

S. Akagi, A. Yamamoto, T. Yoshimori, R. Masaki, R. Ogawa, Y. Tashiro

Journal of Histochemistry and Cytochemistry　Vol. 36　p. 1069-1074　1988/01/01

Binding Properties of Monoclonal Antibody to the Cytoplasmic Domain of Transferrin Receptor

Tamotsu Yoshimori, Yasutsugu Shimonishi, Tsuyoshi Uchida

Cell Structure and Function　Vol. 13　No. 4　p. 311-324　1988　Research paper (scientific journal)

MONOCLONAL-ANTIBODIES AGAINST DIPHTHERIA-TOXIN FRAGMENT-A - CHARACTERIZATION AND INTRODUCTION INTO LIVING CELLS

T YOSHIMORI, M YAMADA, H SUGAWA, E MEKADA, T UCHIDA, Y OKADA

EXPERIMENTAL CELL RESEARCH　Vol. 151　No. 2　p. 344-353　1984　Research paper (scientific journal)