Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice

Yuma Saeki, Kazuma Higashisaka, Rina Izutani, Jiwon Seo, Kazuki Miyaji, Yuya Haga, Yasuo Tsutsumi

ACS Nanoscience Au　Vol. 4　No. 5　p. 317-321　2024/08/29　Research paper (scientific journal)

Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches

Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Sota Manabe, Wakaba Idehara, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Ecotoxicology and Environmental Safety　Vol. 277　p. 116346-116346　2024/06　Research paper (scientific journal)

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

eLife　Vol. 12　2024/03/26　Research paper (scientific journal)

Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells

Hiroto Konishi, Yuya Haga, Moe Okumura, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Cell Death Discovery　Vol. 10　No. 1　2024/03/01　Research paper (scientific journal)

Polyglycerol fatty acid ester contributes to the improvement and maintenance of water solubility of amorphous curcumin by suppressing the intermolecular interaction and the diffusion rate of curcumin

Kazuya Nagano, Tomohiro Nakao, Mariko Takeda, Haruna Hirai, Hikaru Maekita, Michiko Nakamura, Naoki Imakawa, Ayako Egawa, Toshimichi Fujiwara, Jian-Qing Gao, Keigo Kinoshita, Makoto Sakata, Masayuki Nishino, Takuya Yamashita, Takuya Yoshida, Kazuo Harada, Keisuke Tachibana, Takefumi Doi, Kazumasa Hirata, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Food Chemistry　Vol. 437　p. 137866-137866　2024/03　Research paper (scientific journal)

Valproic acid elevates HIF-1α-mediated <i>CGB</i> expression and suppresses glucose uptake in BeWo cells

Go Kitahara, Kazuma Higashisaka, Yurina Nakamoto, Rena Yamamoto, Wakako Okuno, Momoe Serizawa, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Yasuo Tsutsumi

The Journal of Toxicological Sciences　Vol. 49　No. 2　p. 69-77　2024　Research paper (scientific journal)

Evidence-Based Prediction of Cellular Toxicity for Amorphous Silica Nanoparticles

Martin, Reiko Watanabe, Kosuke Hashimoto, Kazuma Higashisaka, Yuya Haga, Yasuo Tsutsumi, Kenji Mizuguchi

ACS Nano　Vol. 17　No. 11　p. 9987-9999　2023/05/31　Research paper (scientific journal)

Impact of Degradation of Polyethylene Particles on Their Cytotoxicity

Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi

Microplastics　Vol. 2　No. 2　p. 192-201　2023/05/22　Research paper (scientific journal)

Fluorouracil exacerbates alpha-crystallin B chain—mediated cell migration in triple-negative breast cancer cell lines

Lili Yang, Yuya Haga, Akihide Nishimura, Yuki Tsujii, Suzuno Tanahashi, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Scientific Reports　Vol. 13　No. 1　2023/03/10　Research paper (scientific journal)

Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts

Atsushi Furuta, Tomoko Shima, Mihoko Yoshida-Kawaguchi, Kiyotaka Yamada, Ippei Yasuda, Sayaka Tsuda, Akemi Yamaki-Ushijima, Satoshi Yoneda, Kazuma Higashisaka, Shi-Bin Cheng, Kenji Matsumoto, Yasuo Tsutsumi, Surendra Sharma, Shigeru Saito, Akitoshi Nakashima

Journal of Reproductive Immunology　Vol. 155　p. 103766-103766　2023/02　Research paper (scientific journal)

Molecular mechanism of cerebral edema improvement via IL-1RA released from the stroke-unaffected hindlimb by treadmill exercise after cerebral infarction in rats.

Rina Gono, Kana Sugimoto, Chihpin Yang, Yukie Murata, Reiko Nomura, Mai Shirazaki, Kazuo Harada, Teiji Harada, Yohei Miyashita, Kazuma Higashisaka, Ryuichi Katada, Hiroshi Matsumoto

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　2023/01/18　Research paper (scientific journal)

Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells

Yuji Sakahashi, Kazuma Higashisaka, Ryo Isaka, Rina Izutani, Jiwon Seo, Atsushi Furuta, Akemi Yamaki-Ushijima, Hirofumi Tsujino, Yuya Haga, Akitoshi Nakashima, Yasuo Tsutsumi

Nanotoxicology　Vol. 16　No. 9-10　p. 883-894　2023/01/03　Research paper (scientific journal)

Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis

Hiroto Konishi, Yuya Haga, Ying Lin, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Biochemical and Biophysical Research Communications　Vol. 641　p. 116-122　2023/01　Research paper (scientific journal)

Silver Nanoparticles Suppress Retinoic Acid-Induced Neuronal Differentiation in Human-Derived Neuroblastoma SH-SY5Y Cells

Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

ACS Applied Nano Materials　Vol. 5　No. 12　p. 19025-19034　2022/12/23　Research paper (scientific journal)

Amorphas Silica Nanoparticles Decrease Human Chorionic Gonadotropin β Expression During Syncytialization of BeWo Cell

Yuji Sakahashi, Rena Yamamoto, Go Kitahara, Rina Izutani, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi

BPB Reports　Vol. 5　No. 6　p. 154-158　2022/12　Research paper (scientific journal)

The Autophagy-Lysosomal Machinery Enhances Cytotrophoblast–Syncytiotrophoblast Fusion Process

Furuta A, Shima T, Kawaguchi M, Yamaki-Ushijima A, Yasuda I, Tsuda S, Yoneda S, Higashisaka K, Cheng SB, Matsumoto K, Tsutsumi Y, Sharma S, Saito S, Nakashima A

Reprod. Med.　Vol. 3　No. 2　p. 112-126　2022/05/05　Research paper (scientific journal)

Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice

Takaki Nakajima, Kazuya Nagano, Yuka Fukuda, Yu Ishima, Hiroko Shibata, Ryo Isaka, Tian-qi Zhang, Yuya Haga, Kazuma Higashisaka, Hirofumi Tsujino, Tatsuhiro Ishida, Akiko Ishii-Watabe, Yasuo Tsutsumi

Journal of Pharmaceutical Sciences　Vol. 111　No. 5　p. 1363-1369　2022/05　Research paper (scientific journal)

Amorphous silica nanoparticles (nSP50) exacerbate hepatic damage through the activation of acquired cell-mediated immunity

Shun-ichi Eto, Kazuma Higashisaka, Aoi Koshida, Kenta Sato, Mao Ogura, Miyuki Sakurai, Hirofumi Tsujino, Kazuya Nagano, Yasuo Tsutsumi

Nano Express　Vol. 3　No. 1　p. 015002-015002　2022/01/27　Research paper (scientific journal)

Silica particles with human protein corona shows sensitization potential in the human cell line activation test

Eto S, Koshida A, Tsujino H, Nagano K, Higashisaka K, Tsutsumi Y

BPB Reports　Vol. 5　No. 1　p. 1-4　2022/01　Research paper (scientific journal)

Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR

Lili Yang, Kazuma Higashisaka, Masafumi Shimoda, Yuya Haga, Naoki Sekine, Hirofumi Tsujino, Kazuya Nagano, Kenzo Shimazu, Yasuo Tsutsumi

Biochemical and Biophysical Research Communications　Vol. 588　p. 175-181　2022/01　Research paper (scientific journal)

Identification of biomarkers of chronic kidney disease among kidney-derived proteins

Higashisaka K, Takeya S, Kamada H, Obana M, Maeda M, Kabayama M, Yamamoto K, Ishida N, Isaka R, Tsujino H, Nagano K, Tomiyama N, Rakugi H, Fujio Y, Kamide K, Tsutsumi Y

Clin. Proteomics　Vol. 19　No. 1　2022/01

Barium-induced toxic anterior segment syndrome

Kenji Matsushita, Rumi Kawashima, Noriyasu Hashida, Yuki Hamano, Kazuo Harada, Kazuma Higashisaka, Koichi Baba, Shigeru Sato, Weiran Huang, Hiroshi Matsumoto, Teruhiko Hamanaka, Andrew J. Quantock, Kohji Nishida

European Journal of Ophthalmology　Vol. 33　No. 3　p. NP31-NP35　2021/12/30　Research paper (scientific journal)

Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells

Yang L, Higashisaka K, Haga Y, Tsujino H, Nagano K, Tsutsumi Y

Pharmazie　2021/12

Indoxyl Sulfate Induces an Inflammatory Response in the Proximal Tubule via Macrophages

Isaka R, Ishida N, Kitahara G, Sakahashi Y, Haga Y, Tsujino H, Nagano K, Higashisaka K, Tsutsumi Y

BPB Reports　Vol. 4　No. 6　p. 198-201　2021/11　Research paper (scientific journal)

Progesterone receptor membrane component 2 expression leads to erlotinib resistance in lung adenocarcinoma cells

Hanamuro S, Lin Y, Konishi H, Izusawa K, Yang L, Haga Y, Tsujino H, Nagano K, Higashisaka K, Tsutsumi Y

Pharmazie　2021/11

Development and Evaluation of a System for the Semi-Quantitative Determination of the Physical Properties of Skin After Exposure to Silver Nanoparticles

Tao H, Nagano K, Tasaki I, Zhang TQ, Ishizaka T, Gao JQ, Harada K, Hirata K, Tsujino H, Higashisaka K, Tsutsumi Y

Nanoscale Research Letters　Vol. 15　No. 1　p. 187-187　2020/12　Research paper (scientific journal)

Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release

Murata Y., Sugimoto K., Yang C., Harada K., Gono R., Harada T., Miyashita Y., Higashisaka K., Katada R., Tanaka J., Matsumoto H.

Neurochemistry International　Vol. 140　p. 104848-104848　2020/11　Research paper (scientific journal)

Silver nanoparticles induce DNA hypomethylation through proteasome-mediated degradation of DNA methyltransferase 1

Maki A, Lin Y, Aoyama M, Sato K, Gao JQ, Tsujino H, Nagano K, Higashisaka K, Tsutsumi Y

Biol. Pharm. Bull　Vol. 43　No. 12　p. 1924-1930　2020/10　Research paper (scientific journal)

Inhibition of Akt/mTOR pathway overcomes intrinsic resistance to dasatinib in triple-negative breast cancer

Haga Y., Higashisaka K., Yang L., Sekine N., Lin Y., Tsujino H., Nagano K., Tsutsumi Y.

Biochem. Biophys. Res. Commun.　Vol. 533　No. 4　p. 672-678　2020/10　Research paper (scientific journal)

Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells.

Ying Lin, Kazuma Higashisaka, Takuya Shintani, Ayaka Maki, Sachiyo Hanamuro, Yuya Haga, Shinichiro Maeda, Hirofumi Tsujino, Kazuya Nagano, Yasushi Fujio, Yasuo Tsutsumi

Scientific reports　Vol. 10　No. 1　p. 4748-4748　2020/03/16　Research paper (scientific journal)

Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats

Chihpin Yang, Kana Sugimoto, Yukie Murata, Yuichiro Hirata, Yu Kamakura, Yoshihisa Koyama, Yohei Miyashita, Kentaro Nakama, Kazuma Higashisaka, Kazuo Harada, Ryuichi Katada, Hiroshi Matsumoto

SCIENTIFIC REPORTS　Vol. 10　No. 1　2020/02　Research paper (scientific journal)

Development and evaluation of a simultaneous and efficient quantification strategy for final prostanoid metabolites in urine.

Zhang TQ., Kuroda H., Nagano K., Terada S., Gao JQ., Harada K., Hirata K., Tsujino H., Higashisaka K., Matsumoto H., Tsutsumi Y.

Prostaglandins Leukot. Essent. Fatty Acids　2019/11

Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis through the activation of MAPK signaling

Yamashita T, Kamada H, Kanasaki S, Nagano K, Inoue M, Higashisaka K, Yoshioka Y, Tsutsumi Y, Tsunoda S

Pharmazie　Vol. 74　No. 10　p. 614-619　2019

Autophagy is a new protective mechanism against the cytotoxicity of platinum nanoparticles in human trophoblasts

Nakashima A, Higashisaka K, Kusabiraki T, Aoki A, Ushijima A, Ono Y, Tsuda S, Shima T, Yoshino O, Nagano K, Yoshioka Y, Tsutsumi Y, Saito S

Sci. Rep.　Vol. 9　No. 1　2019

Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body.

Takuya Ishizaka, Kazuya Nagano, Ikkei Tasaki, Hong Tao, Jian-Qing Gao, Kazuo Harada, Kazumasa Hirata, Shigeru Saito, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi

Nanoscale research letters　Vol. 14　No. 1　p. 180-180　2019　Research paper (scientific journal)

Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.

Shintani T, Higashisaka K, Maeda M, Hamada M, Tsuji R, Kurihara K, Kashiwagi Y, Sato A, Obana M, Yamamoto A, Kawasaki K, Lin Y, Kijima T, Kinehara Y, Kumagai T, Imamura F, Miwa Y, Maeda S, Morii E, Kumanogoh A, Tsutsumi Y, Nagatomo I, Fujio Y

Oncotarget　Vol. 9　No. 101　p. 37520-37533　2018/12/25　Research paper (scientific journal)

Neutrophil depletion exacerbates pregnancy complications, including placental damage, induced by silica nanoparticles in mice.

Higashisaka K, Nakashima A, Iwahara Y, Aoki A, Nakayama M, Yanagihara I, Lin Y, Nagano K, Tsunoda S, Saito S, Yoshioka Y, Tsutsumi Y

Front. Immunol.　Vol. 9　2018

Intracellular trafficking of particles inside endosomal vesicles is regulated by particle size

Aoyama M, Yoshioka Y, Arai Y, Hirai H, Ishimoto R, Nagano K, Higashisaka K, Nagai T, Tsutsumi Y

J. Controlled Release　Vol. 260　p. 183-193　2017/08　Research paper (scientific journal)

Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes

Takashi Nagano, Kazuya Nagano, Hiromi Nabeshi, Tokuyuki Yoshida, Haruhiko Kamada, Shin-ichi Tsunoda, Jian-Qing Gao, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 40　No. 5　p. 726-728　2017/05　Research paper (scientific journal)

Human scavenger receptor A1-mediated inflammatory response to silica particle exposure is size specific

Nobuo Nishijima, Toshiro Hirai, Kazuki Misato, Michihiko Aoyama, Etsushi Kuroda, Ken J. Ishii, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

Frontiers in Immunology　Vol. 8　No. APR　2017/04/03　Research paper (scientific journal)

Nano-safety Research: Examining the Associations among the Biological Effects of Nanoparticles and Their Physicochemical Properties and Kinetics

Kazuma Higashisaka, Kazuya Nagano, Yasuo Yoshioka, Yasuo Tsutsumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 40　No. 3　p. 243-248　2017/03

Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure

Shunji Imai, Yuki Morishita, Tomoyuki Hata, Masuo Kondoh, Kiyohito Yagi, Jian-Qing Gao, Kazuya Nagano, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 484　No. 3　p. 543-549　2017/03　Research paper (scientific journal)

Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice

Takayuki Handa, Toshiro Hirai, Natsumi Izumi, Shun-ichi Eto, Shin-ichi Tsunoda, Kazuya Nagano, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 28　No. 13　2017/02　Research paper (scientific journal)

Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats

Kuwagata Makiko, Kumagai Fumiaki, Saito Yoshiaki, Higashisaka Kazuma, Yoshioka Yasuo, Tsutsumi Yasuo

Fundamental Toxicological Sciences　Vol. 4　No. 3　p. 109-119　2017

Chitosan nanoparticles and their Tween 80 modified counterparts disrupt the developmental profile of zebrafish embryos

Zhongyue Yuan, Ying Li, Yulan Hu, Jian You, Kazuma Higashisaka, Kazuya Nagano, Yasuo Tsutsumi, Jianqing Gao

INTERNATIONAL JOURNAL OF PHARMACEUTICS　Vol. 515　No. 1-2　p. 644-656　2016/12　Research paper (scientific journal)

Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

Michihiko Aoyama, Katutomo Hata, Kazuma Higashisaka, Kazuya Nagano, Yasuo Yoshioka, Yasuo Tsutsumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 480　No. 4　p. 690-695　2016/11　Research paper (scientific journal)

Potential Suppressive Effects of Two C-60 Fullerene Derivatives on Acquired Immunity

Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian-Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 11　No. 1　2016/10　Research paper (scientific journal)

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

Yuki Morishita, Yasuo Yoshioka, Yuya Takimura, Yuki Shimizu, Yuki Namba, Nao Nojiri, Takuya Ishizaka, Keizo Takao, Fumiyoshi Yamashita, Kazuhiro Takuma, Yukio Ago, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Shigeru Saito, Toshio Matsuda, Mitsuru Hashida, Tsuyoshi Miyakawa, Kazuma Higashisaka, Yasuo Tsutsumi

ACS NANO　Vol. 10　No. 9　p. 8180-8191　2016/09　Research paper (scientific journal)

Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice

Toshiro Hirai, Yasuo Yoshioka, Natsumi Izumi, Ko-ichi Ichihashi, Takayuki Handa, Nobuo Nishijima, Eiichiro Uemura, Ko-ichi Sagami, Hideki Takahashi, Manami Yamaguchi, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Ken J. Ishii, Kazuma Higashisaka, Yasuo Tsutsumi

NATURE NANOTECHNOLOGY　Vol. 11　No. 9　p. 808-816　2016/09　Research paper (scientific journal)

High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis

T. Hirai, Y. Yoshioka, H. Takahashi, T. Handa, N. Izumi, T. Mori, E. Uemura, N. Nishijima, K. Sagami, M. Yamaguchi, S. Eto, K. Nagano, H. Kamada, S. Tsunoda, K. J. Ishii, K. Higashisaka, Y. Tsutsumi

CLINICAL AND EXPERIMENTAL ALLERGY　Vol. 46　No. 7　p. 992-1003　2016/07　Research paper (scientific journal)

Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide- or peptidoglycan-stimulated RAW264.7 macrophages

Eiichiro Uemura, Yasuo Yoshioka, Toshiro Hirai, Takayuki Handa, Kazuya Nagano, Kazuma Higashisaka, Yasuo Tsutsumi

JOURNAL OF NANOPARTICLE RESEARCH　Vol. 18　No. 6　2016/06　Research paper (scientific journal)

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy

Shintaro Taki, Haruhiko Kamada, Masaki Inoue, Kazuya Nagano, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

PLOS ONE　Vol. 10　No. 12　2015/12　Research paper (scientific journal)

Biodistribution and therapeutic effects of a monoclonal antibody against Eph receptor A10 in a breast cancer xenograft model

Nagano Kazuya, Maeda Yuka, Yamashita Takuya, Mukai Yohei, Kamada Haruhiko, Higashisaka Kazuma, Yoshioka Yasuo, Tsutsumi Yasuo, Tsunoda Shin-ichi

CANCER RESEARCH　Vol. 75　2015/08/01

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

Toshiro Hirai, Yasuo Yoshioka, Hideki Takahashi, Ko-ichi Ichihashi, Asako Udaka, Takahide Mori, Nobuo Nishijima, Tokuyuki Yoshida, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Tatsuya Takagi, Ken J. Ishii, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

PARTICLE AND FIBRE TOXICOLOGY　Vol. 12　2015/06　Research paper (scientific journal)

Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice

Tokuyuki Yoshida, Yasuo Yoshioka, Yuki Morishita, Michihiko Aoyama, Saeko Tochigi, Toshiro Hirai, Kota Tanaka, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 26　No. 24　2015/06　Research paper (scientific journal)

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2

Masaki Inoue, Haruhiko Kamada, Yasuhiro Abe, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

JOURNAL OF CELL SCIENCE　Vol. 128　No. 4　p. 656-669　2015/02　Research paper (scientific journal)

Applications and Safety of Nanomaterials Used in the Food Industry

Higashisaka Kazuma, Yoshioka Yasuo, Tsutsumi Yasuo

Food Safety　Vol. 3　No. 2　p. 39-47　2015

Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3

Haruhiko Kamada, Shintaro Taki, Kazuya Nagano, Masaki Inoue, Daisuke Ando, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 456　No. 4　p. 908-912　2015/01　Research paper (scientific journal)

Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro

Shunji Imai, Yasuo Yoshioka, Yuki Morishita, Tokuyuki Yoshida, Miyuki Uji, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Kazuma Higashisaka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 9　No. 1　2014/12　Research paper (scientific journal)

Evaluation of silica nanoparticle binding to major human blood proteins

Katsutomo Hata, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Yoshioka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 9　No. 1　2014/12　Research paper (scientific journal)

Intestinal absorption and biological effects of orally administered amorphous silica particles

Tokuyuki Yoshida, Yasuo Yoshioka, Hideki Takahashi, Kazuki Misato, Takahide Mori, Toshiro Hirai, Kazuya Nagano, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 9　No. 1　2014/09　Research paper (scientific journal)

Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers

Kazuya Nagano, Yuka Maeda, So-ichiro Kanasaki, Takanobu Watanabe, Takuya Yamashita, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

JOURNAL OF CONTROLLED RELEASE　Vol. 189　p. 72-79　2014/09　Research paper (scientific journal)

Eph receptor A10 has a potential as a target for a prostate cancer therapy

Kazuya Nagano, Takuya Yamashita, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 450　No. 1　p. 545-549　2014/07　Research paper (scientific journal)

Neutrophilia due to silica nanoparticles induces release of double-stranded DNA.

Higashisaka K, Kunieda A, Iwahara Y, Tanaka K, Nagano K, Mukai Y, Kamada H, Tsunoda S, Yoshioka Y, Tsutsumi Y

Journal of Nanomedic. Nanotechnol.　Vol. 5　2014

Asian Dust Particles Induce Macrophage Inflammatory Responses via Mitogen-Activated Protein Kinase Activation and Reactive Oxygen Species Production

Kazuma Higashisaka, Maho Fujimura, Mayu Taira, Tokuyuki Yoshida, Shin-ichi Tsunoda, Takashi Baba, Nobuyasu Yamaguchi, Hiromi Nabeshi, Tomoaki Yoshikawa, Masao Nasu, Yasuo Yoshioka, Yasuo Tsutsumi

JOURNAL OF IMMUNOLOGY RESEARCH　Vol. 2014　2014　Research paper (scientific journal)

Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients

Kazuya Nagano, So-ichiro Kanasaki, Takuya Yamashita, Yuka Maeda, Masaki Inoue, Kazuma Higashisaka, Yasuo Yoshioka, Yasuhiro Abe, Yohei Mukai, Haruhiko Kamada, Yasuo Tsutsumi, Shin-ichi Tsunoda

CANCER MEDICINE　Vol. 2　No. 6　p. 972-977　2013/12　Research paper (scientific journal)

Anti-EphA10 monoclonal antibody is a potential therapy against EphA10 positive breast cancer.

Nagano Kazuya, Maeda Yuka, Yamashita Takuya, Inoue Masaki, Abe Yasuhiro, Mukai Yohei, Kamada Haruhiko, Higashisaka Kazuma, Yoshioka Yasuo, Tsutsumi Yasuo, Tsunoda Shin-ichi

MOLECULAR CANCER THERAPEUTICS　Vol. 12　No. 11　2013/11

Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage

Takashi Nagano, Kazuma Higashisaka, Akiyoshi Kunieda, Yuki Iwahara, Kota Tanaka, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Yasuo Tsutsumi

NANOTECHNOLOGY　Vol. 24　No. 40　2013/10　Research paper (scientific journal)

Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice

Tokuyuki Yoshida, Yasuo Yoshioka, Saeko Tochigi, Toshiro Hirai, Miyuki Uji, Ko-ichi Ichihashi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Kazuma Higashisaka, Tomoaki Yoshikawa, Yasuo Tsutsumi

PARTICLE AND FIBRE TOXICOLOGY　Vol. 10　2013/08　Research paper (scientific journal)

Potential of acute-phase proteins as biomarkers for sub-nano platinum exposure

T. Nagano, Y. Yoshioka, K. Higashisaka, A. Kunieda, K. Hata, K. Nagano, Y. Abe, H. Kamada, S. Tsunoda, H. Nabeshi, T. Yoshikawa, Y. Tsutsumi

PHARMAZIE　Vol. 67　No. 11　p. 958-959　2012/11　Research paper (scientific journal)

Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles

Kazuma Higashisaka, Yasuo Yoshioka, Kohei Yamashita, Yuki Morishita, Huiyan Pan, Toshinobu Ogura, Takashi Nagano, Akiyoshi Kunieda, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 7　No. 1　2012/10　Research paper (scientific journal)

Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages

Hiromi Nabeshi, Tomoaki Yoshikawa, Takanori Akase, Tokuyuki Yoshida, Saeko Tochigi, Toshiro Hirai, Miyuki Uji, Ko-ichi Ichihashi, Takuya Yamashita, Kazuma Higashisaka, Yuki Morishita, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Norio Itoh, Yasuo Yoshioka, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 6　No. 1　2011/07　Research paper (scientific journal)

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

Kohei Yamashita, Yasuo Yoshioka, Kazuma Higashisaka, Kazuya Mimura, Yuki Morishita, Masatoshi Nozaki, Tokuyuki Yoshida, Toshinobu Ogura, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Youko Monobe, Takayoshi Imazawa, Hisae Aoshima, Kiyoshi Shishido, Yuichi Kawai, Tadanori Mayumi, Shin-ichi Tsunoda, Norio Itoh, Tomoaki Yoshikawa, Itaru Yanagihara, Shigeru Saito, Yasuo Tsutsumi

NATURE NANOTECHNOLOGY　Vol. 6　No. 5　p. 321-328　2011/05　Research paper (scientific journal)

Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice

Tokuyuki Yoshida, Yasuo Yoshioka, Maho Fujimura, Kohei Yamashita, Kazuma Higashisaka, Yuki Morishita, Hiroyuki Kayamuro, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Norio Itoh, Tomoaki Yoshikawa, Yasuo Tsutsumi

NANOSCALE RESEARCH LETTERS　Vol. 6　No. 1　2011　Research paper (scientific journal)

Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials

Kazuma Higashisaka, Yasuo Yoshioka, Kohei Yamashita, Yuki Morishita, Maho Fujimura, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Tomoaki Yoshikawa, Norio Itoh, Yasuo Tsutsumi

BIOMATERIALS　Vol. 32　No. 1　p. 3-9　2011/01　Research paper (scientific journal)

Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation

Tokuyuki Yoshida, Yasuo Yoshioka, Maho Fujimura, Kohei Yamashita, Kazuma Higashisaka, Ryosuke Nakanishi, Yuki Morishita, Hiroyuki Kayamuro, Hiromi Nabeshi, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shinichi Tsunoda, Tomoaki Yoshikawa, Norio Itoh, Yasuo Tsutsumi

TOXICOLOGY LETTERS　Vol. 199　No. 3　p. 383-388　2010/12

Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape

Kohei Yamashita, Yasuo Yoshioka, Kazuma Higashisaka, Yuki Morishita, Tokuyuki Yoshida, Maho Fujimura, Hiroyuki Kayamuro, Hiromi Nabeshi, Takuya Yamashita, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Yuichi Kawai, Tadanori Mayumi, Tomoaki Yoshikawa, Norio Itoh, Shin-ichi Tsunoda, Yasuo Tsutsumi

INFLAMMATION　Vol. 33　No. 4　p. 276-280　2010/08　Research paper (scientific journal)

Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo

Tokuyuki Yoshida, Yasuo Yoshioka, Maho Fujimura, Hiroyuki Kayamuro, Kohei Yamashita, Kazuma Higashisaka, Ryosuke Nakanishi, Yuki Morishita, Hiromi Nabeshi, Takuya Yamashita, Masashi Muroi, Kenichi Tanamoto, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Yuichi Kawai, Tadanori Mayumi, Norio Itoh, Tomoaki Yoshikawa, Shinichi Tsunoda, Yasuo Tsutsumi

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 33　No. 5　p. 780-783　2010/05　Research paper (scientific journal)