顔写真

PHOTO

Shimamoto Keiko
島本　啓子
Shimamoto Keiko
島本　啓子
Institutional repository
Graduate School of Science　Department of Chemistry，Specially Appointed Professor (Full Time)

keyword Glycochemistry，Neuro chemistry，Synthetic Organic chemistry

Institutional repository

Research History 10

  1. 2022 - Present
    SUNTORY FOUNDATION FOR LIFE SCIENCES

  2. 2017 - Present
    大阪大学大学院　理学研究科 化学専攻　特任教授（兼任）

  3. 2017 - 2022
    SUNTORY FOUNDATION FOR LIFE SCIENCES

  4. 2011/01 - 2017
    SUNTORY FOUNDATION FOR LIFE SCIENCES

  5. 2007 - 2017
    Osaka City University　Graduate School of Science

  6. 2007 - 2011
    （財）サントリー生物有機科学研究所　主幹研究員・グループ長

  7. 2001 - 2007
    （財）サントリー生物有機科学研究所　主任研究員

  8. 1986 - 2002
    Researcher, Suntory Institute for Bioorganic

  9. 1986 - 2001
    （財）サントリー生物有機科学研究所　研究員

  10. Research

Education 1

  1. 大阪大学大学院　理学研究科　博士（理学）取得

    1991 -

Committee Memberships 5

  1. 日本化学会　理事　Academic society

    2024 - Present

  2. 日本糖質学会　評議員　Academic society

    2013 - Present

  3. 日本化学会 天然物化学・生命科学ディビジョン　主査　Academic society

    2022 - 2024

  4. 日本ケミカルバイオロジー学会　幹事　Academic society

    2018 - 2024

  5. 日本化学会生体機能関連部会　幹事　Academic society

    2006 - 2018

Professional Memberships 5

  1. アメリカ化学会

  2. JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

  3. THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH

  4. 有機合成化学協会

  5. 日本化学会

Research Areas 4

  1. Nanotechnology/Materials / Biochemistry /

  2. Life sciences / Bioorganic chemistry /

  3. Nanotechnology/Materials / Structural/physical organic chemistry /

  4. Nanotechnology/Materials / Molecular biochemistry /

Awards 2

  1. 第31回学術賞

    島本 啓子　日本化学会　2014/03

  2. 第6回山崎貞一賞（バイオサイエンス・バイオテクノロジー分野）

    2006

Papers 94

  1. Synthesis of a fluorescent analog for exploring the functions of the bacterial glycopyrophospholipid MPIase

    Tsukiho Osawa, Kaoru Nomura, Keiko Shimamoto, Kohki Fujikawa

    Carbohydrate Research　Vol. 553　p. 109483-109483　2025/07　Research paper (scientific journal)

    Publisher: Elsevier BV

  2. Membrane tubulation induced by a bacterial glycolipid

    Kaoru Nomura, Akihiro Tsuji, Hayato Yamashita, Masayuki Abe, Kohki Fujikawa, Shoko Mori, Tsukiho Osawa, Hiromi Toyonaga, Tomohiro Osugi, Kazuma Yasuhara, Kenichi Morigaki, Ken-ichi Nishiyama, Keiko Shimamoto

    SCIENTIFIC REPORTS　Vol. 15　No. 1　2025/03/20　Research paper (scientific journal)

  3. Bacterial Glycolipid Acting on Protein Transport Across Membranes

    Shoko Mori, Masafumi Shionyu, Keiko Shimamoto, Kaoru Nomura

    ChemBioChem　Vol. 25　No. 10　2024/04/18　Research paper (scientific journal)

    Publisher: Wiley

  4. Roles of a Glycolipid MPIase in Sec-Independent Membrane Protein Insertion

    Kaoru Nomura, Shoko Mori, Keiko Shimamoto

    Membranes　Vol. 14　No. 2　p. 48-48　2024/02/08　Research paper (scientific journal)

    Publisher: MDPI AG

  5. Key contributions of a glycolipid to membrane protein integration

    Keiko SHIMAMOTO, Kohki FUJIKAWA, Tsukiho OSAWA, Shoko MORI, Kaoru NOMURA, Ken-ichi NISHIYAMA

    Proceedings of the Japan Academy, Series B　Vol. 100　No. 7　p. 387-413　2024　Research paper (scientific journal)

    Publisher: Japan Academy

  6. Structures, functions, and syntheses of glycero-glycophospholipids.

    Tsukiho Osawa, Kohki Fujikawa, Keiko Shimamoto

    Frontiers in chemistry　Vol. 12　p. 1353688-1353688　2024　Research paper (scientific journal)

  7. Identification, Chemical Synthesis, and Sweetness Evaluation of Rhamnose or Xylose Containing Steviol Glycosides of Stevia (Stevia rebaudiana) Leaves.

    Takehiro Watanabe, Kohki Fujikawa, Soichiro Urai, Kazunari Iwaki, Tadayoshi Hirai, Katsuro Miyagawa, Hiroshi Uratani, Tohru Yamagaki, Koji Nagao, Yoshiaki Yokoo, Keiko Shimamoto

    Journal of agricultural and food chemistry　Vol. 71　No. 29　p. 11158-11169　2023/07/26　Research paper (scientific journal)

  8. Evaluation of Drug Responses to Human β2AR Using Native Mass Spectrometry

    Michiko Tajiri, Shunsuke Imai, Tsuyoshi Konuma, Keiko Shimamoto, Ichio Shimada, Satoko Akashi

    ACS Omega　2023/06/28　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  9. Structural Requirements of a Glycolipid MPIase for Membrane Protein Integration.

    Kohki Fujikawa, Youjung Han, Tsukiho Osawa, Shoko Mori, Kaoru Nomura, Maki Muramoto, Ken-Ichi Nishiyama, Keiko Shimamoto

    Chemistry (Weinheim an der Bergstrasse, Germany)　Vol. 29　No. 30　2023/03/10　Research paper (scientific journal)

  10. Role of a bacterial glycolipid in Sec-independent membrane protein insertion.

    Kaoru Nomura, Shoko Mori, Kohki Fujikawa, Tsukiho Osawa, Shugo Tsuda, Kumiko Yoshizawa-Kumagaye, Shun Masuda, Hideki Nishio, Taku Yoshiya, Takao Yoda, Masafumi Shionyu, Tsuyoshi Shirai, Ken-Ichi Nishiyama, Keiko Shimamoto

    Scientific reports　Vol. 12　No. 1　p. 12231-12231　2022/07/18　Research paper (scientific journal)

  11. Intermolecular Interactions between a Membrane Protein and a Glycolipid Essential for Membrane Protein Integration.

    Shoko Mori, Kaoru Nomura, Kohki Fujikawa, Tsukiho Osawa, Masafumi Shionyu, Takao Yoda, Tsuyoshi Shirai, Shugo Tsuda, Kumiko Yoshizawa-Kumagaye, Shun Masuda, Hideki Nishio, Taku Yoshiya, Sonomi Suzuki, Maki Muramoto, Ken-Ichi Nishiyama, Keiko Shimamoto

    ACS chemical biology　Vol. 17　No. 3　p. 609-618　2022/03/18　Research paper (scientific journal)

  12. A bacterial glycolipid essential for membrane protein integration

    Kohki Fujikawa, Shoko Mori, Ken-ichi Nishiyama, Keiko Shimamoto

    Advances in Carbohydrate Chemistry and Biochemistry　2022　Part of collection (book)

    Publisher: Elsevier

  13. Interaction between glycolipid MPIase and proteinaceous factors during protein integration into the cytoplasmic membrane of E. coli.

    Hanako Nishikawa, Katsuhiro Sawasato, Shoko Mori, Kohki Fujikawa, Kaoru Nomura, Keiko Shimamoto, Ken-Ichi Nishiyama

    Frontiers in molecular biosciences　Vol. 9　p. 986602-986602　2022　Research paper (scientific journal)

  14. Regulation of expression of glycolipid MPIase involved in membrane 5 export of proteins in E. coli ~MPIase, a glycolipid that possesses the enzyme-like activities~

    Sawasato K, Fujikawa K, Shimamoto K, Nishiyama K

    Vol. 印刷中　2020/04　Research paper (scientific journal)

  15. 大腸菌膜タンパク質の膜挿入に関与する酵素様糖脂質MPIase

    藤川 紘樹, 西山 賢一, 島本 啓子

    Trends in Glycoscience and Glycotechnology　Vol. 31　No. 184　p. J149-J155　2019/11

  16. Enzyme-like Glycolipids MPIase Involved in Membrane Protein Integration of E. coli

    Kohki Fujikawa, Ken-ichi Nishiyama, Keiko Shimamoto

    Trends in Glycoscience and Glycotechnology　Vol. 31　No. 184　p. E151-E158　2019/11　Research paper (scientific journal)

    Publisher: Forum: Carbohydrates Coming of Age

  17. Novel glycolipid involved in membrane protein integration: Structure and mode of action

    Fujikawa K, Nomura K, Nishiyama K, Shimamoto K

    J Synth Org Chem Japan　Vol. 77　No. 11　p. 1096-1105　2019/11　Research paper (scientific journal)

    Publisher: The Society of Synthetic Organic Chemistry, Japan

  18. Alteration of Membrane Physicochemical Properties by Two Factors for Membrane Protein Integration.

    Nomura K, Yamaguchi T, Mori S, Fujikawa K, Nishiyama K, Shimanouchi T, Tanimoto Y, Morigaki K, Shimamoto K

    Biophys J　Vol. 117　No. 1　p. 99-110　2019/07　Research paper (scientific journal)

    Publisher: Elsevier BV

  19. Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Ester with Biscarbamate Protection and Its Application to Synthesis of xCT inhibitor.

    Yasuno Y, Mizutani I, Sueuchi Y, Wakabayashi Y, Yasuo N, Shimamoto K, Shinada T

    Chemistry (Weinheim an der Bergstrasse, Germany)　Vol. 25　No. 20　p. 5145-5148　2019/02　Research paper (scientific journal)

  20. CdsA is involved in biosynthesis of glycolipid MPIase essential for membrane protein integration in vivo.

    Sawasato K, Sato R, Nishikawa H, Iimura N, Kamemoto Y, Fujikawa K, Yamaguchi T, Kuruma Y, Tamura Y, Endo T, Ueda T, Shimamoto K, Nishiyama KI

    Scientific reports　Vol. 9　No. 1　2019/02　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  21. A truncated palytoxin analogue, palytoxin carboxylic acid, isolated as an insecticidal compound from the red alga, Chondria armata

    Shoko Mori, Kohtaro Sugahara, Mitsuru Maeda, Keiko Shimamoto, Takashi Iwashita, Tohru Yamagaki

    Tetrahedron Letters　Vol. 59　No. 50　p. 4420-4425　2018/12　Research paper (scientific journal)

    Publisher: Elsevier BV

  22. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.

    Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S Tawaramoto, Takatsugu Hirokawa, Eriko Nango, Kensuke Tono, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, Keiko Shimamoto, Masaki Yamamoto, Daniel M Rosenbaum, So Iwata, Tatsuro Shimamura, Takuya Kobayashi

    Structure (London, England : 1993)　Vol. 26　No. 1　p. 7-19　2018/01/02　Research paper (scientific journal)

  23. Syntheses and Activities of the Functional Structures of a Glycolipid Essential for Membrane Protein Integration

    K. Fujikawa, S. Suzuki, R. Nagase, S. Ikeda, S. Mori, K. Nomura, K. Nishiyama, K. Shimamoto

    ACS Chem. Biol.　Vol. 13　No. 9　p. 2719-2727　2018　Research paper (scientific journal)

    Publisher: American Chemical Society (ACS)

  24. Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells

    Taisuke Miyazaki, Miwako Yamasaki, Kouichi Hashimoto, Kazuhisa Kohda, Michisuke Yuzaki, Keiko Shimamoto, Kohichi Tanaka, Masanobu Kano, Masahiko Watanabe

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 114　No. 28　p. 7438-7443　2017/07　Research paper (scientific journal)

  25. The Role of the Prod1 Membrane Anchor in Newt Limb Regeneration

    Kaoru Nomura, Yasushi Tanimoto, Fumio Hayashi, Erisa Harada, Xiao-Yuan Shan, Masafumi Shionyu, Atsushi Hijikata, Tsuyoshi Shirai, Kenichi Morigaki, Keiko Shimamoto

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 56　No. 1　p. 270-274　2017/01　Research paper (scientific journal)

  26. The Role of the Prod1 Membrane Anchor in Newt Limb Regeneration

    Kaoru Nomura, Yasushi Tanimoto, Fumio Hayashi, Erisa Harada, Xiao-Yuan Shan, Masafumi Shionyu, Atsushi Hijikata, Tsuyoshi Shirai, Kenichi Morigaki, Keiko Shimamoto

    Angewandte Chemie　Vol. 129　No. 1　2016/11

    Publisher: Wiley-Blackwell

  27. Structure-activity relationship study at C9 position of kaitocephalin

    Yoko Yasuno, Makoto Hamada, Yuya Yoshida, Keiko Shimamoto, Yasushi Shigeri, Toshifumi Akizawa, Motomi Konishi, Yasufumi Ohfune, Tetsuro Shinada

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 26　No. 15　p. 3543-3546　2016/08　Research paper (scientific journal)

  28. Elucidation of Excitatory Neurotransmission and Membrane Protein Integration Mechanisms

    Keiko Shimamoto

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　Vol. 89　No. 3　p. 282-295　2016/03　Research paper (scientific journal)

  29. (7S)-Kaitocephalin as a potent NMDA receptor selective ligand

    Yoko Yasuno, Makoto Hamada, Masanori Kawasaki, Keiko Shimamoto, Yasushi Shigeri, Toshifumi Akizawa, Motomi Konishi, Yasufumi Ohfune, Tetsuro Shinada

    ORGANIC & BIOMOLECULAR CHEMISTRY　Vol. 14　No. 4　p. 1206-1210　2016　Research paper (scientific journal)

  30. “糖脂質酵素（Glycolipozyme）”MPIaseの構造と作用機作

    西山賢一, 島本啓子

    酵素工学　Vol. 74　p. 14-18　2015/10

  31. Design and Synthesis of a Berberine Dimer: A Fluorescent Ligand with High Affinity towards G-Quadruplexes

    Masayuki Tera, Takatsugu Hirokawa, Sachiko Okabe, Kohtaro Sugahara, Hiroyuki Seimiya, Keiko Shimamoto

    CHEMISTRY-A EUROPEAN JOURNAL　Vol. 21　No. 41　p. 14519-14528　2015/10　Research paper (scientific journal)

  32. Glycolipozyme membrane protein integrase (MPIase): Recent data

    Ken-Ichi Nishiyama, Keiko Shimamoto

    Biomolecular Concepts　Vol. 5　No. 5　p. 429-438　2014/10/01　Research paper (scientific journal)

    Publisher: De Gruyter Mouton

  33. A novel glutamate transporter blocker, LL-TBOA, attenuates ischaemic injury in the isolated, perfused rat heart despite low transporter levels

    Vladimir Martinov, Yvette Dehnes, Silvia Holmseth, Keiko Shimamoto, Niels Christian Danbolt, Guro Valen

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY　Vol. 45　No. 4　p. 710-716　2014/04　Research paper (scientific journal)

  34. Solid-state NMR spectra of lipid-anchored proteins under magic angle spinning

    Kaoru Nomura, Erisa Harada, Kenji Sugase, Keiko Shimamoto

    Journal of Physical Chemistry B　Vol. 118　No. 9　p. 2405-2413　2014/03/06　Research paper (scientific journal)

    Publisher: American Chemical Society

  35. Solid-State NMR Spectra of Lipid-Anchored Proteins under Magic Angle Spinning

    Kaoru Nomura, Erisa Harada, Kenji Sugase, Keiko Shimamoto

    JOURNAL OF PHYSICAL CHEMISTRY B　Vol. 118　No. 9　p. 2405-2413　2014/03　Research paper (scientific journal)

  36. 膜タンパク質膜挿入の鍵を握る糖脂質酵素MPIase

    島本啓子, 西山賢一

    生命化学研究レター　Vol. 44　p. 9-14　2014/02

  37. Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe

    Shingo Sasaki, Hiroto Suzuki, Hitoshi Ouchi, Tomohiro Asakawa, Makoto Inai, Ryuichi Sakai, Keiko Shimamoto, Yoshitaka Hamashima, Toshiyuki Kan

    ORGANIC LETTERS　Vol. 16　No. 2　p. 564-567　2014/01　Research paper (scientific journal)

  38. Kinetic Resolution and Stereoselective Synthesis of 3-Substituted Aspartic Acids by Using Engineered Methylaspartate Ammonia Lyases

    Hans Raj, Wiktor Szymanski, Jandre de Villiers, Vinod Puthan Veetil, Wim J. Quax, Keiko Shimamoto, Dick B. Janssen, Ben L. Feringa, Gerrit J. Poelarends

    CHEMISTRY-A EUROPEAN JOURNAL　Vol. 19　No. 34　p. 11148-11152　2013/08　Research paper (scientific journal)

  39. MPIase is a glycolipozyme essential for membrane protein integration

    Ken-ichi Nishiyama, Masahide Maeda, Kayo Yanagisawa, Ryohei Nagase, Hajime Komura, Takashi Iwashita, Tohru Yamagaki, Shoichi Kusumoto, Hajime Tokuda, Keiko Shimamoto

    NATURE COMMUNICATIONS　Vol. 3　2012/12　Research paper (scientific journal)

  40. 1 Function and Structure of Novel Glycolipid Characterized as Membrane Protein Integrase(Oral Presentation)

    Maeda Masahide, Nishiyama Ken-ichi, Nagase Ryohei, Iwashita Takashi, Komura Hajime, Tokuda Hajime, Kusumoto Shoichi, Shimamoto Keiko

    Symposium on the Chemistry of Natural Products, symposium papers　No. 53　p. 1-6　2011/09/02

    Publisher: Symposium on the chemistry of natural products

  41. Glutamate transporter GLAST is essential for cytodifferentiation of Bergmann glia and maintenance of excitatory synaptic wiring in the cerebellum

    Taisuke Miyazaki, Miwako Yamasaki, Kouichi Hashimoto, Keiko Shimamoto, Kazuhisa Kohda, Michisuke Yuzaki, Kohichi Tanaka, Masanobu Kano, Masahiko Watanabe

    NEUROSCIENCE RESEARCH　Vol. 71　p. E63-E63　2011

  42. Novel N-Methylated 8-Oxoisoguanines from Pacific Sponges with Diverse Neuroactivities

    Tsuyoshi Sakurada, Martin B. Gill, Shanti Frausto, Bryan Copits, Keiichi Noguchi, Keiko Shimamoto, Geoffrey T. Swanson, Ryuichi Sakai

    JOURNAL OF MEDICINAL CHEMISTRY　Vol. 53　No. 16　p. 6089-6099　2010/08　Research paper (scientific journal)

  43. Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs

    Masato Oikawa, Minoru Ikoma, Makoto Sasaki, Martin B. Gill, Geoffrey T. Swanson, Keiko Shimamoto, Ryuichi Sakai

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 18　No. 11　p. 3795-3804　2010/06　Research paper (scientific journal)

  44. A novel complete reconstitution system for membrane integration of the simplest membrane protein

    Ken-ichi Nishiyama, Masahide Maeda, Masato Abe, Takashi Kanamori, Keiko Shimamoto, Shoichi Kusumoto, Takuya Ueda, Hajime Tokuda

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 394　No. 3　p. 733-736　2010/04　Research paper (scientific journal)

  45. Regioselective Domino Metathesis of Unsymmetrical 7-Oxanorbornenes with Electron-Rich Vinyl Acetate toward Biologically Active Glutamate Analogues

    Masato Oikawa, Minoru Ikoma, Makoto Sasaki, Martin B. Gill, Geoffrey T. Swanson, Keiko Shimamoto, Ryuichi Sakai

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　Vol. 5531　No. 32　p. 5531-5548　2009/11　Research paper (scientific journal)

  46. Thiol addition to t-butyl methyl squarate. Efficient synthesis of novel sulfur-linked squaryl group-containing glutamate analogs

    Tetsuro Shinada, Atsuko Yamasaki, Yu-ichi kiniwa, Keiko Shimamoto, Yasufumi Ohfune

    TETRAHEDRON LETTERS　Vol. 50　No. 30　p. 4354-4357　2009/07　Research paper (scientific journal)

  47. Regioselective Domino Metathesis of 7-Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate Analogues

    Minoru Ikoma, Masato Oikawa, Martin B. Gill, Geoffrey T. Swanson, Ryuichi Sakai, Keiko Shimamoto, Makoto Sasaki

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　No. 31　p. 5215-5220　2008/11　Research paper (scientific journal)

  48. Low-affinity excitatory amino acid uptake in hippocampal astrocytes: A possible role of Na+/dicarboxylate cotransporters

    Holten Aleksander Talgoy, Danbolt Niels Christian, Shimamoto Keiko, Gundersen Vidar

    GLIA　Vol. 56　No. 9　p. 990-997　2008/07　Research paper (scientific journal)

  49. Glutamate transporter blockers for elucidation of the function of excitatory neurotransmission systems

    Keiko Shimamoto

    CHEMICAL RECORD　Vol. 8　No. 3　p. 182-199　2008　Research paper (scientific journal)

  50. Rapid and efficient synthesis of dysiherbaine and analogues to explore structure - Activity relationships

    Makoto Sasaki, Koichi Tsubone, Kunimori Aoki, Nobuyuki Akiyama, Muneo Shoji, Masato Oikawa, Ryuichi Sakai, Keiko Shimamoto

    JOURNAL OF ORGANIC CHEMISTRY　Vol. 73　No. 1　p. 264-273　2008/01　Research paper (scientific journal)

  51. Glutamate transporter GLAST/EAAT1 directs cell surface expression of FXYD2/gamma subunit of Na, K-ATPase in human fetal astrocytes

    Marina Gegelashvili, Anna Rodriguez-Kern, Luther Sung, Keiko Shimamoto, Georgi Gegelashvili

    NEUROCHEMISTRY INTERNATIONAL　Vol. 50　No. 7-8　p. 916-920　2007/06　Research paper (scientific journal)

  52. Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters

    Keiko Shimamoto, Yasuto Otsubo, Yasushi Shigeri, Yoshimi Yasuda-Kamatani, Masamichi Satoh, Shuji Kaneko, Takayuki Nakagawa

    MOLECULAR PHARMACOLOGY　Vol. 71　No. 1　p. 294-302　2007/01　Research paper (scientific journal)

  53. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

    Olga Boudker, Renae M. Ryan, Dinesh Yernool, Keiko Shimamoto, Eric Gouaux

    NATURE　Vol. 445　No. 7126　p. 387-393　2007/01　Research paper (scientific journal)

  54. Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes

    Makoto Sasaki, Koichi Tsubone, Muneo Shoji, Masato Okawa, Keiko Shimamoto, Ryuichi Sakai

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 16　No. 22　p. 5784-5787　2006/11　Research paper (scientific journal)

  55. P-227 SYNTHESIS AND CHARACTERIZATION OF NOVEL BLOCKERS TO PROBE GLUTAMATE TRANSPORTER FUNCTIONS

    Shimamoto Keiko, Sakai Ryuichi, Shigeri Yasushi, Nakagawa Takayuki

    International Symposium on the Chemistry of Natural Products　Vol. 2006　p. "P-227"　2006/07/23

    Publisher: Symposium on the chemistry of natural products

  56. Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport

    Diane B. Re, Imane Nafia, Christophe Melon, Keiko Shimamoto, Lydia Kerkerian-Le Goff, Laurence Had-Aissouni

    GLIA　Vol. 54　No. 1　p. 47-57　2006/07　Research paper (scientific journal)

  57. Total synthesis and biological evaluation of neodysiherbaine A and analogues

    Muneo Shoji, Nobuyuki Akiyama, Koichi Tsubone, L. Leanne Lash, James M. Sanders, Geoffrey T. Swanson, Ryuichi Sakai, Keiko Shimamoto, Masato Oikawa, Makoto Sasaki

    JOURNAL OF ORGANIC CHEMISTRY　Vol. 71　No. 14　p. 5208-5220　2006/07　Research paper (scientific journal)

  58. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover

    Y Takayasu, M Iino, K Shimamoto, K Tanaka, S Ozawa

    JOURNAL OF NEUROSCIENCE　Vol. 26　No. 24　p. 6563-6572　2006/06　Research paper (scientific journal)

  59. Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance

    L Shachnai, K Shimamoto, BI Kanner

    NEUROPHARMACOLOGY　Vol. 49　No. 6　p. 862-871　2005/11　Research paper (scientific journal)

  60. Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons

    HS Waagepetersen, H Qu, U Sonnewald, K Shimamoto, A Schousboe

    NEUROCHEMISTRY INTERNATIONAL　Vol. 47　No. 1-2　p. 92-102　2005/07　Research paper (scientific journal)

  61. A novel L-glutamate transporter inhibitor reveals endogenous D-aspartate homeostasis in rat pheochromocytoma MPT1 cells

    H Koyama, M Sekine, T Furuchi, M Katane, N Nimura, K Shimamoto, T Nakajima, H Homma

    LIFE SCIENCES　Vol. 76　No. 25　p. 2933-2944　2005/05　Research paper (scientific journal)

  62. Effects of a novel glutamate transporter blocker, (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy} aspartate (TFB-TBOA), on activities of hippocampal neurons

    S Tsukada, M Iino, Y Takayasu, K Shimamoto, S Ozawa

    NEUROPHARMACOLOGY　Vol. 48　No. 4　p. 479-491　2005/03　Research paper (scientific journal)

  63. Synthesis of optically active beta-alkyl aspartate via [3,3] sigmatropic rearrangement of alpha-acyloxytrialkylsilane

    K Sakaguchi, M Yamamoto, T Kawamoto, T Yamada, T Shinada, K Shimamoto, Y Ohfune

    TETRAHEDRON LETTERS　Vol. 45　No. 30　p. 5869-5872　2004/07　Research paper (scientific journal)

  64. Synthesis of carbamate-type caged derivatives of a novel glutamate transporter blocker

    K Takaoka, Y Tatsu, N Yumoto, T Nakajima, K Shimamoto

    BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 12　No. 13　p. 3687-3694　2004/07　Research paper (scientific journal)

  65. Molecular pharmacology of glutamate transporters, EAATs and VGLUTs

    Y Shigeri, RP Seal, K Shimamoto

    BRAIN RESEARCH REVIEWS　Vol. 45　No. 3　p. 250-265　2004/07

  66. Stereoselective nucleophilic addition with a new chiral template and its application to the synthesis of optically active alpha-arylglycine derivatives

    S Tohma, K Rikimaru, A Endo, K Shimamoto, T Kan, T Fukuyama

    SYNTHESIS-STUTTGART　No. 6　p. 909-917　2004/04　Research paper (scientific journal)

  67. L-Glutamate in the extracellular space regulates endogenous D-aspartate homeostasis in rat pheochromocytoma MPT1 cells

    Minako Adachi, Hayato Koyama, Zhiqun Long, Masae Sekine, Takemitsu Furuchi, Kazuhiro Imai, Noriyuki Nimura, Keiko Shimamoto, Terumi Nakajima, Hiroshi Homma

    Archives of Biochemistry and Biophysics　Vol. 424　No. 1　p. 89-96　2004/04/01　Research paper (scientific journal)

  68. Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters

    K Shimamoto, R Sakai, K Takaoka, N Yumoto, T Nakajima, SG Amara, Y Shigeri

    MOLECULAR PHARMACOLOGY　Vol. 65　No. 4　p. 1008-1015　2004/04　Research paper (scientific journal)

  69. Novel betaines from a micronesian sponge Dysidea herbacea

    R Sakai, K Suzuki, K Shimamoto, H Kamiya

    JOURNAL OF ORGANIC CHEMISTRY　Vol. 69　No. 4　p. 1180-1185　2004/02　Research paper (scientific journal)

  70. Stereocontrolled synthesis of a potent agonist of group II metabotropic glutamate receptors, (+)-LY354740, and its related derivatives

    Y Ohfune, T Demura, S Iwama, H Matsuda, K Namba, K Shimamoto, T Shinada

    TETRAHEDRON LETTERS　Vol. 44　No. 29　p. 5431-5434　2003/07　Research paper (scientific journal)

  71. Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges.

    Sakai R, Matsubara H, Shimamoto K, Jimbo M, Kamiya H, Namikoshi M

    Journal of natural products　Vol. 66　No. 6　p. 784-787　2003/06

    Publisher: 6

  72. Excitatory amino acid transporters: development of regulatory molecules for their functional analysis

    Y Shigeri, K Shimamoto

    SEIKAGAKU　Vol. 75　No. 4　p. 288-292　2003/04　Research paper (scientific journal)

  73. Synthesis and photoreactivity of caged blockers for glutamate transporters

    K Takaoka, Y Tatsu, N Yumoto, T Nakajima, K Shimamoto

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 13　No. 5　p. 965-970　2003/03　Research paper (scientific journal)

  74. Pharmacology of excitatory amino acid transporters (EAATs and VGLUTs)

    Yasushi Shigeri, Keiko Shimamoto

    Folia Pharmacologica Japonica　Vol. 122　No. 3　p. 253-264　2003

    Publisher: 3

  75. Glutamate transporters and retinal excitotoxicity

    Y Izumi, K Shimamoto, AM Benz, SB Hammerman, JW Olney, CF Zorumski

    GLIA　Vol. 39　No. 1　p. 58-68　2002/07　Research paper (scientific journal)

  76. A hydrophobic domain in glautamate transporters forms an extracellular helix associates with the permeation pathway for substrates（jointly worked）

    J. Biol. Chem　Vol. 277, 29847　2002

  77. Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal

    CM Anderson, RJ Bridges, AR Chamberlin, K Shimamoto, Y Yasuda-Kamatani, RA Swanson

    JOURNAL OF NEUROCHEMISTRY　Vol. 79　No. 6　p. 1207-1216　2001/12　Research paper (scientific journal)

  78. 22 Synthesis and Glutamate Transporter Blocker Activity of Hydroxyaspartate Derivatives

    Shimamoto Keiko, Yasuda(Kamatani) Yoshimi, Lebrun Bruno, Sakaitani Masahiro, Nakajima Terumi, Takaoka Kiyo, Shigeri Yasushi, Yumoto Noboru

    Symposium on the Chemistry of Natural Products, symposium papers　No. 43　p. 127-132　2001/09/01

    Publisher: Symposium on the chemistry of natural products

  79. Comparison of effects of DL-threo-beta-benzyloxyaspartate (DL-TBOA) and L-trans-pyrrolidine-2,4-dicarboxylate (t-2,4-PDC) on uptake and release of [H-3]D-aspartate in astrocytes and glutamatergic neurons

    HS Waagepetersen, K Shimamoto, A Schousboe

    NEUROCHEMICAL RESEARCH　Vol. 26　No. 6　p. 661-666　2001/06　Research paper (scientific journal)

  80. Isolation, structure determination, and synthesis of neodysiherbaine A, a new excitatory amino acid from a marine sponge

    R Sakai, T Koike, M Sasaki, K Shimamoto, C Oiwa, A Yano, K Suzuki, K Tachibana, H Kamiya

    ORGANIC LETTERS　Vol. 3　No. 10　p. 1479-1482　2001/05　Research paper (scientific journal)

  81. Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes

    JY Chatton, K Shimamoto, PJ Magistretti

    BRAIN RESEARCH　Vol. 893　No. 1-2　p. 46-52　2001/03　Research paper (scientific journal)

  82. Characterization of the glutamatergic system for induction and maintenance of allodynia（共著）

    Vol. 895-178　2001

  83. Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)

    Yasushi Shigeri, Keiko Shimamoto, Yoshimi Yasuda-Kamatani, Rebecca P. Seal, Noboru Yumoto, Terumi Nakajima, Susan G. Amara

    Journal of Neurochemistry　Vol. 79　No. 2　p. 297-302　2001　Research paper (scientific journal)

  84. 72 SYNTHESES OF CONFORMATIONALLY CONSTRAINED GLUTAMATE ANALOGUES

    Shimamoto K., Raghavan S., Ouerfelli O., Ohfune Y.

    Symposium on the Chemistry of Natural Products, symposium papers　No. 35　p. 559-566　1993/09/10

    Publisher: Symposium on the chemistry of natural products

  85. 7 CONFORMATIONAL REQUIREMENTS OF L-GLUTAMATE RECEPTORS : APPROACHES BY THE SYNTHESIS OF CONFORMATIONALLY CONSTRAINED L-GLUTAMATE ANALOGUES

    Shimamoto Keiko, Raghavan S., Ohfune Yasufumi

    Symposium on the Chemistry of Natural Products, symposium papers　No. 34　p. 47-54　1992/09/10

    Publisher: Symposium on the chemistry of natural products

  86. 2-(CARBOXYCYCLOPROPYL) GLYCINES - BINDING, NEUROTOXICITY AND INDUCTION OF INTRACELLULAR FREE CA-2+ INCREASE

    M KAWAI, Y HORIKAWA, T ISHIHARA, K SHIMAMOTO, Y OHFUNE

    EUROPEAN JOURNAL OF PHARMACOLOGY　Vol. 211　No. 2　p. 195-202　1992/02　Research paper (scientific journal)

  87. A SYNTHESIS OF (-)-BURSATELLIN

    K KAWAMINE, R TAKEUCHI, M MIYASHITA, H IRIE, K SHIMAMOTO, Y OHFUNE

    CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 39　No. 12　p. 3170-3171　1991/12　Research paper (scientific journal)

  88. SYNTHESIS OF 4 DIASTEREOMERIC L-2-(CARBOXYCYCLOPROPYL)GLYCINES - CONFORMATIONALLY CONSTRAINED L-GLUTAMATE ANALOGS

    K SHIMAMOTO, M ISHIDA, H SHINOZAKI, Y OHFUNE

    JOURNAL OF ORGANIC CHEMISTRY　Vol. 56　No. 13　p. 4167-4176　1991/06　Research paper (scientific journal)

  89. 十字路

    小倉 治夫, 大船 泰史, 島本 啓子, 浅野 泰久

    有機合成化学協会誌　Vol. 49　No. 4　p. 350-350　1991

    Publisher: The Society of Synthetic Organic Chemistry, Japan

  90. 23 SYNTHESES AND NEUROACTIVITIES OF α-(CARBOXYCYCLOPROPYL)GLYCINES : CONFORMATIONALLY RESTRICTED ANALOGUES OF THE NEUROTRANSMITTER, L-GLUTAMIC ACID

    Ohfune Y., Shimamoto K., Shinozaki H., Ishida M.

    Symposium on the Chemistry of Natural Products, symposium papers　No. 31　p. 167-174　1989/09/17

    Publisher: Symposium on the chemistry of natural products

  91. Classification of β-hydroxy-L-glutamic acid receptors using novel conformationally fixed analogues

    Hiroshi Takeuchi, Kazuko Watanabe, Philipp Novales-Li, Keiko Shimamoto, Yasufumi Ohfune

    Comparative Biochemistry and Physiology. Part C, Comparative　Vol. 93　No. 2　p. 263-268　1989　Research paper (scientific journal)

  92. CLASSIFICATION OF BETA-HYDROXY-L-GLUTAMIC ACID RECEPTORS USING NOVEL CONFORMATIONALLY FIXED ANALOGS

    H TAKEUCHI, K WATANABE, P NOVALESLI, K SHIMAMOTO, Y OHFUNE

    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY　Vol. 93　No. 2　p. 263-268　1989　Research paper (scientific journal)

  93. Classification of GABA receptors in snail neurones

    Anchalee Yongsiri, Kozo Funase, Hiroshi Takeuchi, Keiko Shimamoto, Yasufumi Ohfune

    European Journal of Pharmacology　Vol. 155　No. 3　p. 239-245　1988/10/18　Research paper (scientific journal)

  94. PC64 SYNTHESES OF TRANS-AND CIS-α-(CARBOXYCYCLOPROPYL)-GLYCINES. NOVEL NEUROACTIVE AMINO ACIDS AS L-GLUTAMATE ANALOGUE

    Shimamoto Keiko, Ohfune Yasufumi, Watanabe Kazuko, Novales-Li Philipp, Takeuchi Hiroshi

    International Symposium on the Chemistry of Natural Products　Vol. 1988　p. 520-520　1988/05/29

    Publisher: Symposium on the chemistry of natural products

Misc. 73

  1. Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Esters with Biscarbamate Protection and Its Application to the Synthesis of xCT Inhibitors

    Yoko Yasuno, Iho Mizutani, Yuki Sueuchi, Yuuka Wakabayashi, Nozomi Yasuo, Keiko Shimamoto, Tetsuro Shinada

    Chemistry - A European Journal　Vol. 25　No. 20　2019/04/05　Rapid communication, short report, research note, etc. (scientific journal)

    Publisher: Wiley-VCH Verlag

  2. タンパク質膜挿入反応に関与する糖脂質酵素MPlaseは生育に必須である

    沢里 克宏, 佐藤 諒, 西川 華子, 飯村 直樹, 藤川 紘樹, 山口 敏幸, 車 ゆうてつ, 田村 康, 遠藤 斗志也, 上田 卓也, 島本 啓子, 西山 賢一

    生命科学系学会合同年次大会　Vol. 2017年度　p. [4AT26-09(3P　2017/12

    Publisher: 生命科学系学会合同年次大会運営事務局

  3. カイトセファリンの構造活性相関によるサブタイプ選択的イオンチャネル型グルタミン酸受容体リガンドの開発

    保野陽子, 濱田まこと, 吉田侑矢, 川崎昌紀, 島本啓子, 茂里康, 秋澤俊史, 小西元美, 大船泰史, 品田哲郎

    天然有機化合物討論会講演要旨集(Web)　Vol. 58th　2016

  4. MFPAの短段階合成と蛍光プローブ化

    OYAGI YU, SASAKI SHINGO, SUZUKI HIROTO, OUCHI HITOSHI, INAI MAKOTO, ASAKAWA TOMOHIRO, SAKAI RYUICHI, SHIMAMOTO KEIKO, HAMASHIMA YOSHITAKA, KAN TOSHIYUKI

    日本薬学会年会要旨集(CD-ROM)　Vol. 135th　2015

  5. MFPAの短段階合成と蛍光プローブ化

    SASAKI SHINGO, SUZUKI HIROTO, OUCHI HITOSHI, ASAKAWA TOMOHIRO, INAI MAKOTO, SAKAI RYUICHI, SHIMAMOTO KEIKO, HAMASHIMA YOSHITAKA, KAN TOSHIYUKI

    反応と合成の進歩シンポジウム講演要旨集　Vol. 40th　2014/10/22

  6. シクロプロパン環を導入した2,6‐ジアミノピメリン酸誘導体の立体選択的合成

    安尾望, 島本啓子, 大船泰史, 品田哲郎

    日本化学会講演予稿集　Vol. 94th　No. 4　2014/03/12

  7. タンパク質ではない酵素？ －タンパク質膜挿入の鍵を握るグライコリポザイム

    西山賢一, 島本啓子

    実験医学増刊 驚愕の代謝システム　Vol. 32　p. 115-122　2014　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  8. シクロプロパン環を導入したジアミノピメリン酸の合成研究

    若林由華, 島本啓子, 品田哲郎, 大船泰史

    日本化学会講演予稿集　Vol. 93rd　No. 4　2013/03/08

  9. 膜タンパク質の鍵は糖脂質にあり －すべての生体膜挿入に必要な因子を求めて－

    西山賢一, 島本啓子

    化学　Vol. 68　No. 6　p. 30-34　2013　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

    Publisher: 化学同人

  10. 立体配座を固定した2,6‐ジアミノピメリン酸誘導体の合成研究

    若林由華, 末内優輝, 島本啓子, 品田哲郎, 大船泰史

    日本化学会講演予稿集　Vol. 92nd　No. 4　2012/03/09

  11. パラオ産海綿より得られた新規プリン化合物の構造と神経調節活性

    櫻田剛史, GILL Martin B, FRAUSTO Shanti, COPITS Bryan, 野口恵一, 島本啓子, SWANSON Geoffrey T, 酒井隆一

    日本水産学会大会講演要旨集　Vol. 2011　2011/03/27

  12. カイトセファリン類縁体の合成と神経活性

    越智小央里, 品田哲郎, 大船泰史, 島本啓子

    日本化学会講演予稿集　Vol. 91st　No. 4　2011/03/11

  13. 35 Stereocontrolled Synthesis of (+)-Methoxyphenylkainic acid(Oral Presentation)

    Asakawa Tomohiro, Sakai Ryuichi, Hamashima Yoshitaka, Kan Toshiyuki, Ohuchi Hitosi, Suzuki Hiroto, Isobe Youichiro, Higashia Takumi, Okazakia Yuko, Wakimoto Toshiyuki, Furuta Takumi, Shimamoto Keiko

    Symposium on the Chemistry of Natural Products, symposium papers　Vol. 53　No. 0　p. 205-210　2011

    Publisher: Symposium on the Chemistry of Natural Products Steering Committee

  14. パラオ産海綿より得られた新規プリン化合物の構造と神経調節活性

    櫻田剛史, GILL Martin B, FRAUSTO Shanti, COPITS Bryan, 野口恵一, 島本啓子, SWANSON Geoffrey T, 酒井隆一

    日本水産学会北海道支部大会講演要旨集　Vol. 2010　2010

  15. Novel N-Methylated 8-Oxoisoguanines from Pacific Sponges with Diverse Neuroactivies

    Sakurada Tsuyoshi, Gill Martin B, Frausto Shanti, Copits Bryan, Noguchi Keiichi, Shimamoto Keiko, Swanson Geoffrey T., Sakai Ryuichi

    Symposium on the Chemistry of Natural Products, symposium papers　Vol. 52　No. 0　p. 625-630　2010

    Publisher: Symposium on the Chemistry of Natural Products Steering Committee

  16. カイトセファリンの構造活性相関研究

    品田哲郎, 濱田まこと, 森正広, 大船泰史, 島本啓子

    メディシナルケミストリーシンポジウム講演要旨集　Vol. 28th　p. 368-369　2009/11/10

  17. Low-Affinity Excitatory Amino Acid Uptake in Hippocampal Astrocytes: A Possible Role of Na(+)/Dicarboxylate Cotransporters (vol 56, pg 990, 2008)

    Holten Aleksander, Talgoy Danbolt Niels Christian, Shimamoto Keiko, Gundersen Vidar

    GLIA　Vol. 57　No. 1　p. 118-118　2009/01　Other

  18. Efficient Total Synthesis of Kaitocephalin and its Structure-activity Relationship Study

    Shinada Tetsuro, Hamada Makoto, Mori Masahiro, Ohfune Yasufumi, Shimamoto Keiko

    Proceedings of the Symposium on Progress in Organic Reactions and Syntheses　Vol. 35　No. 0　p. 28-28　2009

    Publisher: 日本薬学会化学系薬学部会

  19. Efficient Total Synthesis of Kaitocephalin and Neurobiological Evaluation of Its Analogs

    Hamada Makoto, Mori Masahiro, Shinada Tetsuro, Ohfune Yasufumi, Shimamoto Keiko

    Symposium on the Chemistry of Natural Products, symposium papers　Vol. 51　No. 0　p. 401-406　2009

    Publisher: 天然有機化合物討論会実行委員会

  20. ダイシハーベインおよび類縁体の全合成および生物活性

    局興一, 青木邦衛, 及川雅人, 酒井隆一, 島本啓子, 佐々木誠

    日本化学会講演予稿集　Vol. 88th　No. 2　2008/03/12

  21. Development of high affinity blockers for glutamate transporters

    Vol. 59　No. 1　p. 73-79　2008　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

    Publisher: 金原一郎記念医学医療振興財団

  22. P-72 Total Synthesis and Biological Evaluation of Dysiherbaine and Analogues

    Tsubone Koichi, Akiyama Nobuyuki, Aoki Kunimori, Oikawa Masato, Sakai Ryuichi, Shimamoto Keiko, Sasaki Makoto

    Symposium on the Chemistry of Natural Products, symposium papers　Vol. 49　No. 0　p. 691-696　2007

    Publisher: Symposium on the Chemistry of Natural Products Steering Committee

  23. 毒を作って何になる……?! ――神経伝達機構の解明で活躍する化合物TBOA

    島本啓子

    化学　Vol. 62　No. 11　p. 39-42　2007　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

    Publisher: 化学同人

  24. [Pharmacology of inhibitory amino acid transporters (GABA transporters and glycine transporters)].

    Shigeri Y, Shimamoto K

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 127　No. 4　p. 279-287　2006/04

    Publisher: 4

  25. Total Synthesis and Biological Evaluation of Dysiherbaine Analogues (1)

    SHOJI MUNEO, AKIYAMA NOBUYUKI, LASH L. L, SANDERS J. M, SWANSON G. T, SAKAI RYUICHI, SHIMAMOTO KEIKO, OIKAWA MASATO, SASAKI MAKOTO

    日本化学会講演予稿集　Vol. 86th　No. 2　2006/03/13

  26. Total Synthesis and Biological Evaluation of Dysiherbaine Analogue (2)

    SHOJI MUNEO, TSUBONE KOICHI, SAKAI RYUICHI, SHIMAMOTO KEIKO, OIKAWA MASATO, SASAKI MAKOTO

    日本化学会講演予稿集　Vol. 86th　No. 2　2006/03/13

  27. Elucidation of glutamate transporter functions using selective inhibitors

    K. Shimamoto, Y. Shigeri

    Central Nervous System Agents in Medicinal Chemistry　Vol. 6　No. 1　p. 59-71　2006　Book review, literature introduction, etc.

  28. Dysiherbaine: A new generation of excitatory amino acids of marine origin

    Ryuichi Sakai, Geoffrey T. Swanson, Makoto Sasaki, Keiko Shimamoto, Hisao Kamiya

    Central Nervous System Agents in Medicinal Chemistry　Vol. 6　No. 2　p. 83-108　2006　Book review, literature introduction, etc.

    Publisher: Bentham Science Publishers Ltd.

  29. Pharmacology of inhibitory amino acid transporters (GABA transporters and glycine transporters)

    SHIGERI Yasushi, SHIMAMOTO Keiko

    Folia Pharmacologica Japonica　Vol. 127　No. 4　p. 279-287　2006　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: The Japanese Pharmacological Society

  30. Function of Neurotransmitter Amino Acid Transporters

    SHIGERI Yasushi, SHIMAMOTO Keiko

    Seibutsu Butsuri　Vol. 46　No. 1　p. 10-14　2006　Article, review, commentary, editorial, etc. (scientific journal)

    Publisher: The Biophysical Society of Japan General Incorporated Association

  31. 9 Total Synthesis and biological evaluation of dysiherbaine analogues

    Shoji Muneo, Shiohara Kaoru, Oikawa Masato, Sakai Ryuichi, Sanders James M., Swanson Geoffrey T., Shimamoto Keiko, Sasaki Makoto

    Symposium on the Chemistry of Natural Products, symposium papers　Vol. 47　No. 0　p. 49-54　2005

    Publisher: Symposium on the Chemistry of Natural Products Steering Committee

  32. 興奮性神経伝達の恒常性維持 －グルタミン酸トランスポーターの役割解明を目指して

    島本啓子

    神経研究の進歩　Vol. 49　No. 6　p. 850-854　2005　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

    Publisher: 医学書院

  33. Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, high affinity blockers for the glutamate transporters

    Y Shigeri, R Sakai, K Takaoka, N Yumoto, T Nakajima, S Amara, K Shimamoto

    JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 94　p. 163P-163P　2004　Research paper, summary (international conference)

  34. Physiological study of an excitatory amino acid dysiherbaine.

    Sakai Ryuichi, Swanson Geffery T, Shimammoto Keiko, Kamiya Hisao

    Proceedings of Annual Meeting of the Physiological Society of Japan　Vol. 2004　No. 0　p. S13-S13　2004

    Publisher: PHYSIOLOGICAL SOCIETY OF JAPAN

  35. 海綿より単離された新規興奮性アミノ酸Cribronic acidの構造と活性

    酒井隆一, 松原裕樹, 神保充, 神谷久男, 島本啓子, 浪越通夫

    日本水産学会大会講演要旨集　Vol. 2003　2003/04/01

  36. グルタミン酸トランスポーターの薬理学

    茂里康, 島本啓子

    日薬理誌　Vol. 122　p. 253-264　2003　Article, review, commentary, editorial, etc. (scientific journal)

  37. 興奮性神経伝達物質グルタミン酸トランスポーターの制御分子と機能解析

    茂里康, 島本啓子

    生化学　Vol. 75　p. 288-292　2003　Article, review, commentary, editorial, etc. (scientific journal)

  38. 50(P-11) Excitatory Amino Acids and Related Compounds from Micronesian Sponges

    Sakai Ryuichi, Suzuki Katsuji, Ishida Makiko, Kamiya Hisao, Sasaki Makoto, Tachibana Kazuo, Koike Tatsuki, Shimamoto Keiko, Namikoshi Michio

    Symposium on the Chemistry of Natural Products, symposium papers　Vol. 44　No. 0　p. 295-300　2002

    Publisher: Symposium on the Chemistry of Natural Products Steering Committee

  39. Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea

    R Sakai, GT Swanson, K Shimamoto, T Green, A Contractor, A Ghetti, Y Tamura-Horikawa, C Oiwa, H Kamiya

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 296　No. 2　p. 650-658　2001/02

  40. Characterization of the glutamatergic system for induction and maintenance of allodynia（jointly worked）

    Vol. 895-178　2001

  41. Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers

    K Shimamoto, Y Shigeri, Y Yasuda-Kamatani, B Lebrun, N Yumoto, T Nakajima

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 10　No. 21　p. 2407-2410　2000/11

  42. Role of glutamate-uptake by Muller cells in retinal excitotoxicity

    Y Izumi, AM Benz, K Shimamoto, SB Hammerman, CF Zorumski, JW Olney

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　Vol. 41　No. 4　p. S188-S188　2000/03　Research paper, summary (international conference)

  43. Efficient synthesis of a novel 4-hydroxy-2,3-dioxocyclobut-1-enyl group containing amino acids

    T Shinada, K Hayashi, T Hayashi, Y Yoshida, M Horikawa, K Shimamoto, Y Shigeri, N Yumoto, Y Ohfune

    ORGANIC LETTERS　Vol. 1　No. 10　p. 1663-1666　1999/11

  44. Substrate turnover by transporters curtails synaptic glutamate transients

    S Mennerick, WX Shen, WY Xu, A Benz, K Tanaka, K Shimamoto, KE Isenberg, JE Krause, CF Zorumski

    JOURNAL OF NEUROSCIENCE　Vol. 19　No. 21　p. 9242-9251　1999/11

  45. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin

    D Jabaudon, K Shimamoto, Y Yasuda-Kamatani, M Scanziani, BH Gahwiler, U Gerber

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 96　No. 15　p. 8733-8738　1999/07

  46. Competitive blockers for the glutamate/aspartate transporter（jointly worked）

    Neurochem Research　Vol. 24　1999

  47. Intramolecular [2+2] photocycloaddition of fumaramic acid ester derivatives. Syntheses of 2-(2,3-dicarboxycyclobutyl)glycines

    H Tsujishima, K Shimamoto, Y Shigeri, N Yumoto, Y Ohfune

    HETEROCYCLES　Vol. 49　p. 73-78　1998/12

  48. Physiological activity of new erethismic neurotoxin Dysiherbaine.

    SAKAI RYUICHI, KAMIYA HISAO, SHIMAMOTO KEIKO, HORIKAWA YOSHIKO, MIYAMAE TAKEAKI

    日本水産学会大会講演要旨集　Vol. 1998　1998/04

  49. Photocycloaddition of alpha,beta-unsaturated-gamma-lactam with ethylene. Synthesis of conformationally restricted glutamate analogs, L-2-(2-carboxycyclobutyl)glycines

    H Tsujishima, K Nakatani, K Shimamoto, Y Shigeri, N Yumoto, Y Ohfune

    TETRAHEDRON LETTERS　Vol. 39　No. 10　p. 1193-1196　1998/03

  50. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters

    K Shimamoto, B LeBrun, Y Yasuda-Kamatani, M Sakaitani, Y Shigeri, N Yumoto, T Nakajima

    MOLECULAR PHARMACOLOGY　Vol. 53　No. 2　p. 195-201　1998/02

  51. New beta-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter

    B Lebrun, M Sakaitani, K Shimamoto, Y YasudaKamatani, T Nakajima

    JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 272　No. 33　p. 20336-20339　1997/08

  52. Dysiherbaine: A new neurotoxic amino acid from the Micronesian marine sponge Dysidea herbacea

    R Sakai, H Kamiya, M Murata, K Shimamoto

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 119　No. 18　p. 4112-4116　1997/05

  53. 興奮性神経伝達機構を探る化合物（共著）

    大船泰史, 島本啓子

    現代化学　No. 11　p. 18-26　1997　Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  54. Protection by diphenyliodonium against glutamate neurotoxicity due to blocking of N-methyl-D-aspartate receptors

    Y Nakamura, K Tsuji, M Shuto, K Ogita, Y Yoneda, K Shimamoto, T Shibata, K Kataoka

    NEUROSCIENCE　Vol. 76　No. 2　p. 459-466　1997/01

  55. Syntheses of trans-3'-substituted-CCG-IV analogs and their characterization to ionotropic glutamate receptors

    K Shimamoto, Y Shigeri, T Nakajima, N Yumoto, S Yoshikawa, Y Ohfune

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 6　No. 20　p. 2381-2386　1996/10

  56. Syntheses and conformational analyses of glutamate analogs: 2-(2-Carboxy-3-substituted-cyclopropyl) glycines as useful probes for excitatory amino acid receptors

    K Shimamoto, Y Ohfune

    JOURNAL OF MEDICINAL CHEMISTRY　Vol. 39　No. 2　p. 407-423　1996/01

  57. INVERSION OF CIS-SUBSTITUTED ALPHA-CYCLOPROPYL ACYL ANION - STEREOSELECTIVE ENTRY TO THE SYNTHESIS OF A POTENT METABOTROPIC GLUTAMATE AGONIST, (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE (L-CCG-I), AND ITS 3'-SUBSTITUTED ANALOGS

    K SHIMAMOTO, Y OHFUNE

    SYNLETT　No. 12　p. 919-920　1993/12　Article, review, commentary, editorial, etc. (scientific journal)

  58. A NOVEL METABOTROPIC GLUTAMATE-RECEPTOR AGONIST - MARKED DEPRESSION OF MONOSYNAPTIC EXCITATION IN THE NEWBORN RAT ISOLATED SPINAL-CORD

    M ISHIDA, T SAITOH, K SHIMAMOTO, Y OHFUNE, H SHINOZAKI

    BRITISH JOURNAL OF PHARMACOLOGY　Vol. 109　No. 4　p. 1169-1177　1993/08

  59. SYNTHESIS OF L-2-(2,3-DICARBOXYCYCLOPROPYL)GLYCINES - NOVEL CONFORMATIONALLY RESTRICTED GLUTAMATE ANALOGS

    Y OHFUNE, K SHIMAMOTO, M ISHIDA, H SHINOZAKI

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 3　No. 1　p. 15-18　1993/01

  60. Inversion of cis-Substituted α-Cyclopropyl Carbonyl Anion Efficient Routes to the Synthesis of a Potent Metabotropic Agonist, (2S, 1'S, 2'S)-2-(Carboxycyclopropyl)glycine(CCG-I)(jointly worked)

    Synlett　Vol. 919-920　1993

  61. Synthesis of Four Diastereomeric L-2-(Carboxycyclopropyl)glycines. Conformationally Constrained L-Glutamate Analogues

    Keiko Shimamoto, Yasufumi Ohfune, Michiko Ishida, Haruhikio Shinozaki

    Journal of Organic Chemistry　Vol. 56　No. 13　p. 4167-4176　1991/06/01

  62. CHANGES IN PREFERENCE FOR RECEPTOR SUBTYPES OF CONFIGURATIONAL VARIANTS OF A GLUTAMATE ANALOG - CONVERSION FROM THE NMDA-TYPE TO THE NON-NMDA TYPE

    M ISHIDA, Y OHFUNE, Y SHIMADA, K SHIMAMOTO, H SHINOZAKI

    BRAIN RESEARCH　Vol. 550　No. 1　p. 152-156　1991/05　Article, review, commentary, editorial, etc. (scientific journal)

  63. SYNTHESIS AND NEUROBIOLOGICAL ACTION OF L-GLUTAMATE ANALOGS

    Y OHFUNE, K SHIMAMOTO

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN　Vol. 49　No. 4　p. 302-313　1991/04　Book review, literature introduction, etc.

  64. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF BULGECINS WITH BULGE-INDUCING ACTIVITY IN GRAM-NEGATIVE BACTERIA

    T WAKAMIYA, Y KIMURA, S TAKAHASHI, KS YAMANOI, M NISHIKAWA, K KANOU, K OHYAMA, T SHIBA

    PEPTIDE CHEMISTRY 1990　Vol. 1990, 103　p. 103-108　1991

  65. A POTENT METABOTROPIC GLUTAMATE RECEPTOR AGONIST - ELECTROPHYSIOLOGICAL ACTIONS OF A CONFORMATIONALLY RESTRICTED GLUTAMATE ANALOG IN THE RAT SPINAL-CORD AND XENOPUS OOCYTES

    M ISHIDA, H AKAGI, K SHIMAMOTO, Y OHFUNE, H SHINOZAKI

    BRAIN RESEARCH　Vol. 537　No. 1-2　p. 311-314　1990/12　Article, review, commentary, editorial, etc. (scientific journal)

  66. USE OF POTASSIUM PEROXODISULFATE FOR BENZYLIC OXIDATION AND OXIDATIVE COUPLING OF BENZOYLACETATES

    H IRIE, J MARUYAMA, M SHIMADA, Y ZHANG, KOUNO, I, K SHIMAMOTO, Y OHFUNE

    SYNLETT　Vol. 1990　No. 7　p. 421-423　1990/07

  67. SYNTHESES OF 3'-SUBSTITUTED-2-(CARBOXYCYCLOPROPYL)GLYCINES VIA INTRAMOLECULAR CYCLOPROPANATION - THE FOLDED FORM OF L-GLUTAMATE ACTIVATES THE NON-NMDA RECEPTOR SUBTYPE

    K SHIMAMOTO, Y OHFUNE

    TETRAHEDRON LETTERS　Vol. 31　No. 28　p. 4049-4052　1990

  68. Use of K2S2O8 for Benzylic Oxidation and Oxidative Coupling of Benzoyl Acetates（jointly worked）

    Synlett　Vol. 421　1990

  69. POTENT NMDA-LIKE ACTIONS AND POTENTIATION OF GLUTAMATE RESPONSES BY CONFORMATIONAL VARIANTS OF A GLUTAMATE ANALOG IN THE RAT SPINAL-CORD

    H SHINOZAKI, M ISHIDA, K SHIMAMOTO, Y OHFUNE

    BRITISH JOURNAL OF PHARMACOLOGY　Vol. 98　No. 4　p. 1213-1224　1989/12

  70. A CONFORMATIONALLY RESTRICTED ANALOG OF L-GLUTAMATE, THE (2S,3R,4S) ISOMER OF L-ALPHA-(CARBOXYCYCLOPROPYL)GLYCINE, ACTIVATES THE NMDA-TYPE RECEPTOR MORE MARKEDLY THAN NMDA IN THE ISOLATED RAT SPINAL-CORD

    H SHINOZAKI, M ISHIDA, K SHIMAMOTO, Y OHFUNE

    BRAIN RESEARCH　Vol. 480　No. 1-2　p. 355-359　1989/02　Article, review, commentary, editorial, etc. (scientific journal)

  71. NEW ROUTES TO THE SYNTHESES OF CIS-ALPHA-(CARBOXYCYCLOPROPYL)GLYCINES FROM L-GLUTAMIC ACID - CONFORMATIONALLY RESTRICTED ANALOGS OF THE EXCITATORY NEUROTRANSMITTER L-GLUTAMIC ACID

    K SHIMAMOTO, Y OHFUNE

    TETRAHEDRON LETTERS　Vol. 30　No. 29　p. 3803-3804　1989

  72. SYNTHESES OF TRANS-ALPHA-(CARBOXYCYCLOPROPYL)GLYCINES AND CIS-ALPHA-(CARBOXYCYCLOPROPYL)GLYCINES - NOVEL NEUROINHIBITORY AMINO-ACIDS AS L-GLUTAMATE ANALOG

    K YAMANOI, Y OHFUNE, K WATANABE, PN LI, H TAKEUCHI

    TETRAHEDRON LETTERS　Vol. 29　No. 10　p. 1181-1184　1988

  73. A NEW ENTRY TO THE SYNTHESIS OF BETA-HYDROXYTYROSINES VIA A NOVEL BENZYLIC HYDROXYLATION

    K SHIMAMOTO, Y OHFUNE

    TETRAHEDRON LETTERS　Vol. 29　No. 40　p. 5177-5180　1988

Publications 1

  1. 天然物の化学 －魅力と展望－

    島本 啓子

    東京化学同人　2016　Scholarly book

Presentations 10

  1. Novel glycolipid involved in membrane protein integration

    SHIMAMOTO Keiko

    The 11th international symposium on integrated synthesis (ISONIS-11) & The 3rd international symposium middle molecular strategy (ISMMS-3)　2017/11/17

  2. 膜タンパク質膜挿入の鍵を握る糖脂質

    島本 啓子

    広島大学 総合科学部講演会　2017/09/14

  3. 膜タンパク質膜挿入の鍵を握る糖脂質 その構造と機能

    島本 啓子

    大阪大学 化学高分子コロキウム　2017/03/01

  4. 膜タンパク質膜挿入の鍵を握る糖脂質 その構造と機能

    島本 啓子

    静岡県立大 薬学部セミナー　2017/02/23

  5. 生物も頑張って磨いている合成技術

    島本 啓子

    日本化学会 化学フェスタ　2016/11/15

  6. 膜タンパク質膜挿入の鍵を握る糖脂質 その構造と機能

    島本 啓子

    日本薬学会東海支部特別講演会　2016/11/11

  7. Identification of a Novel Glycolipid Essential for Membrane Protein Integration

    SHIMAMOTO Keiko

    2016/03/24

  8. 膜タンパク質挿入の鍵を握る糖脂質

    島本 啓子

    創薬懇話会　2015/07/02

  9. 膜タンパク質挿入の鍵を握る糖脂質MPIase

    島本 啓子

    新学術領域ケミカルバイオロジー東北地区ミニシンポジウム　2015/06/30

  10. 膜タンパク質挿入の鍵を握る糖脂質MPIase

    島本 啓子

    徳島大学薬学部講演会　2015/04/22

Works 3

  1. Preparation of affinity column for isolation of glutamate transporter

    1999 -

  2. Molecular mechanizm on excitatory neurotransmission

    1999 -

  3. 糖脂質の合成

    島本 啓子

Industrial Property Rights 7

  1. ベンゼン環上に二置換基を有するβ−ベンジルオキシアスパラギン酸誘導体

    島本 啓子

    特許第4008446号

    出願日:2004/12/27

  2. β−ヒドロキシアスパラギン酸誘導体

    島本 啓子, 安田 好美, 堺谷 政弘

    特許第3936418号

    出願日:1996/10/25

  3. 放射性ラベル基を有する3−[3−(ベンゾイルアミド)ベンジルオキシ]アスパラギン酸誘導体とその製造方法

    島本 啓子, 佐治 英郎, 久下 裕司, 上田 真史, 佐藤 公道, 中川 貴之

    特許第5311739号

    出願日:2005/03/18

  4. 光感受性基を有するβ−ベンジルオキシアスパラギン酸誘導体

    島本 啓子, 高岡 季代

    特許第4372751号

    出願日:2003/05/30

  5. ベンゼン環上にアミノ基を有するβ−ベンジルオキシアスパラギン酸誘導体

    島本 啓子

    特許第4542336号

    出願日:2002/06/24

  6. Beta-hydroxy aspartic acid derivatives

  7. Beta-hydroxy aspartic acid derivatives

Institutional Repository 1

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. Synthesis and Neuroexcitatory Action of Conformationally Constrained Glutamate Analogues

    島本 啓子