顔写真

PHOTO

Kouda Tooru
甲田　亨
Kouda Tooru
甲田　亨
Institutional repository
Co-Creation Bureau, Associate Professor
Institutional repository

Research Areas 1

  1. Life sciences / Neurology /

Papers 31

  1. Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering.

    Ryohei Yamamura, Makoto Kinoshita, Yoshiaki Yasumizu, Tomohiro Yata, Keigo Kihara, Daisuke Motooka, Naoyuki Shiraishi, Yasuko Sugiyama, Shohei Beppu, Hisashi Murata, Naoshi Koizumi, Itsuki Sano, Toru Koda, Tatsusada Okuno, Hideki Mochizuki

    Frontiers in immunology　Vol. 16　p. 1508977-1508977　2025　Research paper (scientific journal)

  2. Switching disease-modifying therapies from sphingosine-1-phosphate receptor modulators to natalizumab or dimethyl fumarate restores immune responses after SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis.

    Minami Kanakura, Keigo Kihara, Makoto Kinoshita, Tomoyuki Sugimoto, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Toru Koda, Masanori P Takahashi, Ichino Chinen, Tatsusada Okuno, Hideki Mochizuki

    Clinical neurology and neurosurgery　Vol. 243　p. 108378-108378　2024/06/15　Research paper (scientific journal)

  3. RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS

    Mikito Shimizu, Naoyuki Shiraishi, Satoru Tada, Tsutomu Sasaki, Goichi Beck, Seiichi Nagano, Makoto Kinoshita, Hisae Sumi, Tomoyuki Sugimoto, Yoko Ishida, Toru Koda, Teruyuki Ishikura, Yasuko Sugiyama, Keigo Kihara, Minami Kanakura, Tsuneo Nakajima, Shuko Takeda, Masanori P. Takahashi, Toshihide Yamashita, Tatsusada Okuno, Hideki Mochizuki

    Science Advances　Vol. 9　No. 47　2023/11/24　Research paper (scientific journal)

    Publisher: American Association for the Advancement of Science (AAAS)

  4. 日本神経学会地方会近畿支部幹事への小児-成人移行医療アンケート調査

    齊藤 利雄, 甲田 亨, 奥野 龍禎, 池田 昭夫, 望月 秀樹, 日本神経学会小児-成人移行医療対策特別委員会

    臨床神経学　Vol. 63　No. 6　p. 409-409　2023/06

    Publisher: (一社)日本神経学会

  5. Food additive succinate exacerbates experimental autoimmune encephalomyelitis accompanied by increased IL-1β production.

    Yasuko Sugiyama, Kazushiro Takata, Makoto Kinoshita, Daisuke Motooka, Naoyuki Shiraishi, Keigo Kihara, Hisashi Murata, Shohei Beppu, Toru Koda, Kazuya Yamashita, Akiko Namba, Kosuke Fujimoto, Atsushi Kumanogoh, Tatsusada Okuno, Hideki Mochizuki

    Biochemical and biophysical research communications　Vol. 656　p. 97-103　2023/05/14　Research paper (scientific journal)

  6. Humoral and cellular responses to SARS-CoV-2 vaccination in patients with autoantibody-mediated neuroimmunology

    Keigo Kihara, Makoto Kinoshita, Tomoyuki Sugimoto, Shuhei Okazaki, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Toru Koda, Tatsusada Okuno, Hideki Mochizuki

    Journal of Neurology, Neurosurgery & Psychiatry　p. jnnp-2022　2023/01/03　Research paper (scientific journal)

    Publisher: BMJ

  7. Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder.

    Mamoru Yamamoto, Tatsusada Okuno, Jin-Lan Piao, Mikito Shimizu, Katsuichi Miyamoto, Takamasa Nukui, Makoto Kinoshita, Toru Koda, Ratna Dini Haryuni, Hideki Mochizuki, Tomoyuki Sugimoto, Yuji Nakatsuji

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia　Vol. 107　p. 129-132　2023/01　Research paper (scientific journal)

  8. Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder.

    Hisashi Murata, Makoto Kinoshita, Yoshiaki Yasumizu, Daisuke Motooka, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Satoru Tada, Toru Koda, Hachiro Konaka, Hyota Takamatsu, Atsushi Kumanogoh, Tatsusada Okuno, Hideki Mochizuki

    Neurology(R) neuroimmunology & neuroinflammation　Vol. 9　No. 3　2022/05　Research paper (scientific journal)

  9. High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD).

    Shohei Beppu, Makoto Kinoshita, Jan Wilamowski, Tadahiro Suenaga, Yoshiaki Yasumizu, Kotaro Ogawa, Teruyuki Ishikura, Satoru Tada, Toru Koda, Hisashi Murata, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Tomoyuki Sugimoto, Hisashi Arase, Daron M Standley, Tatsusada Okuno, Hideki Mochizuki

    Scientific reports　Vol. 12　No. 1　p. 106-106　2022/01/07　Research paper (scientific journal)

  10. Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats.

    Teruyuki Ishikura, Makoto Kinoshita, Mikito Shimizu, Yoshiaki Yasumizu, Daisuke Motooka, Daisuke Okuzaki, Kazuya Yamashita, Hisashi Murata, Shohei Beppu, Toru Koda, Satoru Tada, Naoyuki Shiraishi, Yasuko Sugiyama, Katsuichi Miyamoto, Susumu Kusunoki, Tomoyuki Sugimoto, Atsushi Kumanogoh, Tatsusada Okuno, Hideki Mochizuki

    Journal of neuroinflammation　Vol. 18　No. 1　p. 181-181　2021/08/21　Research paper (scientific journal)

  11. Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation

    Mikito Shimizu, Tatsusada Okuno, Makoto Kinoshita, Hisae Sumi, Harutoshi Fujimura, Kazuya Yamashita, Tomoyuki Sugimoto, Shuhei Sakakibara, Kaori Sakakibara, Toru Koda, Satoru Tada, Teruyuki Ishikura, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Yuji Nakatsuji, Atsushi Kumanogoh, Hideki Mochizuki

    Scientific Reports　Vol. 10　No. 1　2020/12　Research paper (scientific journal)

    Publisher: Springer Science and Business Media LLC

  12. Astrocyte metabolism in multiple sclerosis investigated by 1-C-11 acetate PET.

    Hiroki Kato, Tatsusada Okuno, Kayako Isohashi, Toru Koda, Mikito Shimizu, Hideki Mochizuki, Yuji Nakatsuji, Jun Hatazawa

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　Vol. 41　No. 2　p. 271678X20911469-379　2020/03/13　Research paper (scientific journal)

  13. Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase.

    Toru Koda, Akiko Namba, Makoto Kinoshita, Yuji Nakatsuji, Tomoyuki Sugimoto, Kaori Sakakibara, Satoru Tada, Mikito Shimizu, Kazuya Yamashita, Kazushiro Takata, Teruyuki Ishikura, Syo Murata, Shohei Beppu, Atsushi Kumanogoh, Hideki Mochizuki, Tatsusada Okuno

    Journal of neuroinflammation　Vol. 17　No. 1　p. 82-82　2020/03/13　Research paper (scientific journal)

  14. Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis.

    Satoru Tada, Tatsusada Okuno, Mikito Shimizu, Yoshiki Sakai, Hisae Sumi-Akamaru, Makoto Kinoshita, Kazuya Yamashita, Eri Sanda, Chi-Jing Choong, Akiko Namba, Tsutomu Sasaki, Toru Koda, Kazushiro Takata, Shigeru Miyagawa, Yoshiki Sawa, Yuji Nakatsuji, Hideki Mochizuki

    Scientific reports　Vol. 9　No. 1　p. 5252-5252　2019/03/27　Research paper (scientific journal)

  15. Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder.

    Kazuya Yamashita, Makoto Kinoshita, Katsuichi Miyamoto, Akiko Namba, Mikito Shimizu, Toru Koda, Tomoyuki Sugimoto, Yuki Mori, Yoshichika Yoshioka, Yuji Nakatsuji, Atsushi Kumanogoh, Susumu Kusunoki, Hideki Mochizuki, Tatsusada Okuno

    Journal of neuroinflammation　Vol. 15　No. 1　p. 125-125　2018/04/27　Research paper (scientific journal)

  16. Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx.

    Junji Takasugi, Munehisa Shimamura, Toru Koda, Toshihiro Kishikawa, Atsushi Hanamoto, Hidenori Inohara, Kazuaki Sato, Eiichi Morii, Masakatsu Motomura, Manabu Sakaguchi, Yuji Nakatsuji, Hideki Mochizuki

    Internal medicine (Tokyo, Japan)　Vol. 57　No. 4　p. 587-590　2018/02/15　Research paper (scientific journal)

  17. Beneficial effects of fingolimod in MS patients with high serum Sema4A levels.

    Toru Koda, Akiko Namba, Yuji Nakatsuji, Masaaki Niino, Yusei Miyazaki, Tomoyuki Sugimoto, Makoto Kinoshita, Kazushiro Takata, Kazuya Yamashita, Mikito Shimizu, Toshiyuki Fukazawa, Atsushi Kumanogoh, Hideki Mochizuki, Tatsusada Okuno

    PloS one　Vol. 13　No. 3　2018　Research paper (scientific journal)

  18. Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner

    Josephe A. Honorat, Yuji Nakatsuji, Mikito Shimizu, Makoto Kinoshita, Hisae Sumi-Akamaru, Tsutomu Sasaki, Kazushiro Takata, Toru Koda, Akiko Namba, Kazuya Yamashita, Eri Sanda, Manabu Sakaguchi, Atsushi Kumanogoh, Takashi Shirakura, Mizuho Tamura, Saburo Sakoda, Hideki Mochizuki, Tatsusada Okuno

    PLOS ONE　Vol. 12　No. 11　2017/11　Research paper (scientific journal)

  19. A case of anti-neurofascin 155 antibody-positive combined central and peripheral demyelination successfully treated with plasma exchange

    Mikito Shimizu, Tohru Koda, Yuji Nakatsuji, Hidenori Ogata, Jun-ichi Kira, Hideki Mochizuki

    Clinical Neurology　Vol. 57　No. 1　p. 41-44　2017　Research paper (scientific journal)

    Publisher: Societas Neurologica Japonica

  20. Neuromyelitis optica: Diagnosis and treatment

    Yuji Nakatsuji, Makoto Kinoshita, Tatsusada Okuno, Kazushiro Takata, Toru Koda, Josephe A. Honorat, Saburo Sakoda, Hideki Mochizuki

    Neuroimmunological Diseases　p. 135-152　2016/01/01　Part of collection (book)

    Publisher: Springer Japan

  21. Reply to comment on: Dietary yeasts reduce inflammation in central nervous system via microflora

    Kazushiro Takata, Takayuki Tomita, Tatsusada Okuno, Makoto Kinoshita, Toru Koda, Josephe A. Honorat, Masaya Takei, Kouichiro Hagihara, Tomoyuki Sugimoto, Hideki Mochizuki, Saburo Sakoda, Yuji Nakatsuji

    ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY　Vol. 2　No. 11　p. 1040-1040　2015/11

  22. [Semaphorin 4 in multiple sclerosis].

    Yuji Nakatsuji, Tatsusada Okuno, Toru Koda, Hideki Mochizuki

    Nihon rinsho. Japanese journal of clinical medicine　Vol. 73 Suppl 7　p. 821-5　2015/09　Research paper (scientific journal)

  23. Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora

    Kazushiro Takata, Takayuki Tomita, Tatsusada Okuno, Makoto Kinoshita, Toru Koda, Josephe A. Honorat, Masaya Takei, Kouichiro Hagihara, Tomoyuki Sugimoto, Hideki Mochizuki, Saburo Sakoda, Yuji Nakatsuji

    ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY　Vol. 2　No. 1　p. 56-66　2015/01　Research paper (scientific journal)

  24. C-11-Acetate PET Imaging in Patients with Multiple Sclerosis

    Kazushiro Takata, Hiroki Kato, Eku Shimosegawa, Tatsusada Okuno, Toru Koda, Tomoyuki Sugimoto, Hideki Mochizuki, Jun Hatazawa, Yuji Nakatsuji

    PLOS ONE　Vol. 9　No. 11　2014/11　Research paper (scientific journal)

  25. Neuroprotective effects of a xanthine oxidase inhibitor in progressive EAE by ameliorating mitochondrial dysfunction

    Josephe Archie Honorat, Makoto Kinoshita, Tatsusada Okuno, Kazushiro Takata, Toru Koda, Akiko Namba, Satoru Tada, Takashi Shirakura, Hideki Mochizuki, Saburo Sakoda, Yuji Nakatsuji

    JOURNAL OF NEUROIMMUNOLOGY　Vol. 275　No. 1-2　p. 221-221　2014/10

  26. Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

    Satoru Tada, Tatsusada Okuno, Yasumichi Hitoshi, Teruhito Yasui, Josephe Archie Honorat, Kazushiro Takata, Toru Koda, Hiroshi Shimagami, Choong Chi-Jing, Akiko Namba, Tomoyuki Sugimoto, Saburo Sakoda, Hideki Mochizuki, Hitoshi Kikutani, Yuji Nakatsuji

    JOURNAL OF NEUROINFLAMMATION　Vol. 11　2014/10　Research paper (scientific journal)

  27. Sema4A inhibits the therapeutic effect of IFN-beta in EAE

    Toru Koda, Tatsusada Okuno, Kazushiro Takata, Josephe Archie Honorat, Makoto Kinoshita, Satoru Tada, Masayuki Moriya, Saburo Sakoda, Hideki Mochizuki, Atsushi Kumanogoh, Yuji Nakatsuji

    JOURNAL OF NEUROIMMUNOLOGY　Vol. 268　No. 1-2　p. 43-49　2014/03　Research paper (scientific journal)

  28. Topics of the 29th European Committee for Treatment and Research in Multiple Sclerosis Congress in Copenhagen, Denmark, 2013

    Toru Koda

    Clinical and Experimental Neuroimmunology　Vol. 4　No. 3　p. 354-357　2013/12　Research paper (international conference proceedings)

  29. Xanthine Oxidase Mediates Axonal and Myelin Loss in a Murine Model of Multiple Sclerosis

    Josephe Archie Honorat, Makoto Kinoshita, Tatsusada Okuno, Kazushiro Takata, Toru Koda, Satoru Tada, Takashi Shirakura, Harutoshi Fujimura, Hideki Mochizuki, Saburo Sakoda, Yuji Nakatsuji

    PLOS ONE　Vol. 8　No. 8　2013/08　Research paper (scientific journal)

  30. BAFF Controls Neural Cell Survival through BAFF Receptor

    Satoru Tada, Teruhito Yasui, Yuji Nakatsuji, Tatsusada Okuno, Toru Koda, Hideki Mochizuki, Saburo Sakoda, Hitoshi Kikutani

    PLOS ONE　Vol. 8　No. 7　2013/07　Research paper (scientific journal)

  31. The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells

    Kazushiro Takata, Makoto Kinoshita, Tatsusada Okuno, Masayuki Moriya, Tohru Kohda, Josephe A. Honorat, Tomoyuki Sugimoto, Atsushi Kumanogoh, Hisako Kayama, Kiyoshi Takeda, Saburo Sakoda, Yuji Nakatsuji

    PLOS ONE　Vol. 6　No. 11　2011/11　Research paper (scientific journal)

Misc. 11

  1. Questionnaire for Kinki area Japanese Society of Neurology board members regarding transitional medicine for neurological disease patients

    M.D., Ph.D. Saito Toshio, M.D., Ph.D. Koda Toru, M.D., Ph.D. Okuno Tatsusada, M.D., Ph.D., F.A.C.N.S. Ikeda Akio, M.D., Ph.D. Mochizuki Hideki, The Special Committee for Measures Against Transition from Pediatric to Adult Health Care, Japanese Society of Neurology

    Rinsho Shinkeigaku　Vol. 63　No. 9　p. 559-565　2023

    Publisher: Societas Neurologica Japonica

  2. NMOSD疾患感受性アレルHLA-DQA1 *05:03は高い細胞表面発現とペプチド結合親和性を示す

    別府祥平, 木下允, WILAMOWSKI Jan, 末永忠弘, 安水良明, 小河浩太郎, 石倉照之, 多田智, 甲田亨, 村田尚, 白石直之, 杉山靖子, 木原圭梧, 杉本知之, 荒瀬尚, STANDLEY Daron M., 奥野龍禎, 望月秀樹

    Neuroimmunology　Vol. 27　No. 1　2022

  3. 好中球由来cell-free DNAが視神経脊髄炎におけるタイプ1インターフェロンを誘導する

    村田尚, 村田尚, 木下允, 安水良明, 安水良明, 安水良明, 元岡大祐, 元岡大祐, 別府祥平, 白石直之, 杉山靖子, 木原圭梧, 多田智, 甲田亨, 小中八郎, 高松漂太, 熊ノ郷淳, 熊ノ郷淳, 奥野龍禎, 望月秀樹, 望月秀樹

    Neuroimmunology　Vol. 27　No. 1　2022

  4. 単純血漿交換療法が奏功した抗neurofascin 155抗体陽性中枢末梢連合脱髄症の1例

    清水 幹人, 甲田 亨, 中辻 裕司, 緒方 英紀, 吉良 潤一, 望月 秀樹

    臨床神経学　Vol. 57　No. 1　p. 41-44　2017/01

    Publisher: (一社)日本神経学会

  5. パーキンソニズムで発症した抗NMDA受容体脳炎の1例

    堺 竜介, 甲田 亨, 馬場 孝輔, 奥野 龍禎, 中辻 裕司, 望月 秀樹

    神経治療学　Vol. 34　No. 1　p. 47-50　2017/01

    Publisher: 日本神経治療学会

  6. 症例 心臓血管カテーテル検査に起因するcholesterol crystal embolismによって脳梗塞をきたした一例—Cerebral infarction caused by cholesterol crystal embolism after angiography

    中嶋 容子, 深田 慶, 甲田 亨

    大阪府立急性期・総合医療センター医学雑誌 = Medical journal of Osaka General Medical Center / 大阪府立急性期・総合医療センター紙誌編集委員会 編　Vol. 37　No. 1　p. 87-89　2014

    Publisher: 大阪 : 大阪府立急性期・総合医療センター

  7. Roles of Sema4A in multiple sclerosis and interferon-β therapy efficacy

    Yuji Nakatsuji, Tatsusada Okuno, Toru Koda, Kazushiro Takata, Josephe A. Honorat, Hideki Mochizuki, Atsushi Kumanogoh

    Clinical and Experimental Neuroimmunology　Vol. 4　No. 3　p. 274-282　2013/12　Book review, literature introduction, etc.

  8. 症例 糖尿病性筋萎縮症の一例—A case of diabetic amyotrophy

    廣澤 太輔, 有澤 亜津子, 甲田 亨

    大阪府立急性期・総合医療センター医学雑誌 = Medical journal of Osaka General Medical Center / 大阪府立急性期・総合医療センター紙誌編集委員会 編　Vol. 33　No. 1　p. 53-57　2010

    Publisher: 大阪 : 大阪府立急性期・総合医療センター

  9. 症例 意識障害を来し腹水貯留を認めた特発性細菌性腹膜炎の1剖検例—An autopsy case of spontaneous bacterial peritonitis with ascites-induced impaired consciousness

    隅蔵 大幸, 甲田 亨, 菅瀬 聡子

    大阪府立急性期・総合医療センター医学雑誌 = Medical journal of Osaka General Medical Center / 大阪府立急性期・総合医療センター紙誌編集委員会 編　Vol. 33　No. 1　p. 49-52　2010

    Publisher: 大阪 : 大阪府立急性期・総合医療センター

  10. 食事療法 ALSに対する誤嚥防止術

    甲田 亨

    難病と在宅ケア　Vol. 14　No. 10　p. 44-46　2009/01

    Publisher: (株)日本プランニングセンター

  11. 妊娠を契機に発症及び再燃がみられた抗アクアポリン4抗体陽性視神経脊髄型多発性硬化症の一例

    甲田 亨, 青池 太志, 棚橋 貴夫, 岡崎 知子, 澤田 甚一, 西村 知也, 狭間 敬憲

    大阪府立急性期・総合医療センター医学雑誌　Vol. 30　No. 1　p. 25-27　2008/03

    Publisher: (地独)大阪府立病院機構大阪急性期・総合医療センター

Institutional Repository 2

Content Published in the University of Osaka Institutional Repository (OUKA)

  1. RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS

    Shimizu Mikito, Shiraishi Naoyuki, Tada Satoru, Sasaki Tsutomu, Beck Goichi, Nagano Seiichi, Kinoshita Makoto, Sumi Hisae, Sugimoto Tomoyuki, Ishida Yoko, Koda Toru, Ishikura Teruyuki, Sugiyama Yasuko, Kihara Keigo, Kanakura Minami, Nakajima Tsuneo, Takeda Shuko, Takahashi Masanori, Yamashita Toshihide, Okuno Tatsusada, Mochizuki Hideki

    Science Advances　Vol. 9　No. 47　2023/11/24

  2. Sema4A inhibits the therapeutic effect of IFN-β in EAE

    甲田 亨