keyword MHC，HLA，Autoimmune disease
Osaka University Graduate School of Medicine Division of Preventive and Environmental Medicine
2010/04 - 2014/03
北京大学 基礎医学院 病原生物学専攻 修士課程
2006/09 - 2009/07
日本免疫学会
Life sciences / Immunology /
Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2
Shuhei Higuchi, Yafei Liu, Jun Shimizu, Chikako Ono, Yumi Itoh, Wataru Nakai, Hui Jin, Kazuki Kishida, Kazuo Takayama, Toru Okamoto, Yoshiko Murakami, Taroh Kinoshita, Yoshiharu Matsuura, Tatsuo Shioda, Hisashi Arase
mBio Vol. 16 No. 8 2025/08/13 Research paper (scientific journal)
Publisher: American Society for Microbiology
The Overlooked Stereoisomers of the Ionizable Lipid ALC315
Chandra Kanta De, Masumi Tsuda, Chendan Zhu, Stefanie Dehn, Heike Hinrichs, Nobuya Tsuji, Hui Jin, Hisashi Arase, Shinya Tanaka, Benjamin List
Journal of the American Chemical Society Vol. 147 No. 32 p. 28595-28600 2025/08/01 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Neoself-antigens are the primary target for autoreactive T cells in human lupus
Shunsuke Mori, Masako Kohyama, Yoshiaki Yasumizu, Asa Tada, Kaito Tanzawa, Tatsuya Shishido, Kazuki Kishida, Hui Jin, Masayuki Nishide, Shoji Kawada, Daisuke Motooka, Daisuke Okuzaki, Ryota Naito, Wataru Nakai, Teru Kanda, Takayuki Murata, Chikashi Terao, Koichiro Ohmura, Noriko Arase, Tomohiro Kurosaki, Manabu Fujimoto, Tadahiro Suenaga, Atsushi Kumanogoh, Shimon Sakaguchi, Yoshihiro Ogawa, Hisashi Arase
Cell Vol. 187 No. 21 p. 6071-6087.e20 2024/10 Research paper (scientific journal)
Publisher: Elsevier BV
Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases.
Hui Jin, Hisashi Arase
Advances in experimental medicine and biology Vol. 1444 p. 51-65 2024/03/12 Part of collection (book)
Publisher: Springer Nature Singapore
Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5.
Seisuke Kusano, Sho Ueda, Daisuke Oryoji, Aya Toyoumi, Akiko Hashimoto-Tane, Hiroyuki Kishi, Hiroshi Hamana, Atsushi Muraguchi, Hui Jin, Hisashi Arase, Hiroko Miyadera, Reiko Kishikawa, Yasunobu Yoshikai, Hisakata Yamada, Ken Yamamoto, Yasuharu Nishimura, Takashi Saito, Takehiko Sasazuki, Shigeyuki Yokoyama
International immunology Vol. 35 No. 9 p. 447-458 2023/09/05 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
Rheumatoid factor recognizes specific domains of the IgG heavy chain complexed with HLA class II molecules.
Shanshan Zhang, Hideaki Tsuji, Hui Jin, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Masao Tanaka, Hisashi Arase, Koichiro Ohmura, Akio Morinobu
Rheumatology (Oxford, England) Vol. 62 No. 9 p. 3151-3155 2023/09/01 Research paper (scientific journal)
Publisher: Oxford University Press (OUP)
Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
Hui Jin, Kazuki Kishida, Noriko Arase, Sumiko Matsuoka, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Ken Yamamoto, Takehiko Sasazuki, Hisashi Arase
Science advances Vol. 8 No. 9 2022/03/04 Research paper (scientific journal)
Anti-Double-Stranded DNA Antibodies Recognize DNA Presented on HLA Class II Molecules of Systemic Lupus Erythematosus Risk Alleles.
Hideaki Tsuji, Koichiro Ohmura, Hui Jin, Ryota Naito, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Shuhei Sakakibara, Yuta Kochi, Yukinori Okada, Kazuhiko Yamamoto, Hitoshi Kikutani, Akio Morinobu, Tsuneyo Mimori, Hisashi Arase
Arthritis & rheumatology (Hoboken, N.J.) Vol. 74 No. 1 p. 105-111 2022/01 Research paper (scientific journal)
Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies.
Noriko Arase, Hideaki Tsuji, Hyota Takamatsu, Hui Jin, Hachiro Konaka, Yasuhito Hamaguchi, Kyoko Tonomura, Yorihisa Kotobuki, Ikuko Ueda-Hayakawa, Sumiko Matsuoka, Toru Hirano, Hideki Yorifuji, Hiroyuki Murota, Koichiro Ohmura, Ran Nakashima, Tomoharu Sato, Atsushi Kumanogoh, Ichiro Katayama, Hisashi Arase, Manabu Fujimoto
Journal of autoimmunity Vol. 126 p. 102774-102774 2022/01 Research paper (scientific journal)
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
Yafei Liu, Wai Tuck Soh, Jun-Ichi Kishikawa, Mika Hirose, Emi E Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Atsushi Nakagawa, Takayuki Kato, Masato Okada, Daron M Standley, Tatsuo Shioda, Hisashi Arase
Cell Vol. 184 No. 13 p. 3452-3466 2021/06/24 Research paper (scientific journal)
Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma.
Noriko Arase, Atsushi Tanemura, Hui Jin, Megumi Nishioka, Yumi Aoyama, Naoki Oiso, Kayoko Matsunaga, Tamio Suzuki, Chikako Nishigori, Tatsuyoshi Kawamura, Tadamichi Shimizu, Akiko Ito, Kazuyoshi Fukai, Yuko Abe, Lingli Yang, Daisuke Tsuruta, Keiko Takeoka, Yoshinori Iwatani, Yoh Hidaka, Makoto Nishida, Keiko Yamauchi-Takihara, Hisashi Arase, Manabu Fujimoto, Ichiro Katayama
Journal of dermatological science Vol. 95 No. 2 p. 80-83 2019/08
FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules.
Yuta Shimizu, Masako Kohyama, Hideki Yorifuji, Hui Jin, Noriko Arase, Tadahiro Suenaga, Hisashi Arase
International immunology Vol. 31 No. 5 p. 303-314 2019/04/26 Research paper (scientific journal)
Novel autoantibody against the β2-glycoprotein I/human leucocyte antigen–DR complex in patients with refractory cutaneous ulcers
N. Arase, K. Tanimura, H. Jin, T. Yamaoka, M. Kishibe, M. Nishioka, E. Kiyohara, M. Tani, S. Matsuoka, K. Ohmura, K. Takasugi, T. Yamamoto, H. Murota, H. Arase, I. Katayama
British Journal of Dermatology Vol. 178 No. 1 p. 272-275 2018/01 Research paper (scientific journal)
Publisher: Wiley
Myeloperoxidase/HLA Class II Complexes Recognized by Autoantibodies in Microscopic Polyangiitis.
Ryosuke Hiwa, Koichiro Ohmura, Noriko Arase, Hui Jin, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Chikashi Terao, Tatsuya Atsumi, Hirotsugu Iwatani, Tsuneyo Mimori, Hisashi Arase
Arthritis & rheumatology (Hoboken, N.J.) Vol. 69 No. 10 p. 2069-2080 2017/10 Research paper (scientific journal)
Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.
Shuji Matsuoka, Yasuyuki Ishii, Atsuhito Nakao, Masaaki Abe, Naomi Ohtsuji, Shuji Momose, Hui Jin, Hisashi Arase, Koichi Sugimoto, Yusuke Nakauchi, Hiroshi Masutani, Michiyuki Maeda, Hideo Yagita, Norio Komatsu, Okio Hino
PloS one Vol. 11 No. 3 2016 Research paper (scientific journal)
β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome.
Kenji Tanimura, Hui Jin, Tadahiro Suenaga, Satoko Morikami, Noriko Arase, Kazuki Kishida, Kouyuki Hirayasu, Masako Kohyama, Yasuhiko Ebina, Shinsuke Yasuda, Tetsuya Horita, Kiyoshi Takasugi, Koichiro Ohmura, Ken Yamamoto, Ichiro Katayama, Takehiko Sasazuki, Lewis L Lanier, Tatsuya Atsumi, Hideto Yamada, Hisashi Arase
Blood Vol. 125 No. 18 p. 2835-44 2015/04/30 Research paper (scientific journal)
Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.
Hui Jin, Noriko Arase, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Kenji Tanimura, Sumiko Matsuoka, Kosuke Ebina, Kenrin Shi, Noriko Toyama-Sorimachi, Shinsuke Yasuda, Tetsuya Horita, Ryosuke Hiwa, Kiyoshi Takasugi, Koichiro Ohmura, Hideki Yoshikawa, Takashi Saito, Tatsuya Atsumi, Takehiko Sasazuki, Ichiro Katayama, Lewis L Lanier, Hisashi Arase
Proc. Natl. Acad. Sci. USA Vol. 111 No. 10 p. 3787-92 2014/03/11 Research paper (scientific journal)
Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules.
Yan Jiang, Noriko Arase, Masako Kohyama, Kouyuki Hirayasu, Tadahiro Suenaga, Hui Jin, Maki Matsumoto, Kyoko Shida, Lewis L Lanier, Takashi Saito, Hisashi Arase
International immunology Vol. 25 No. 4 p. 235-46 2013/04 Research paper (scientific journal)
A type-specific nested PCR assay established and applied for investigation of HBV genotype and subgenotype in Chinese patients with chronic HBV infection.
Jing-Jing Nie, Kui-Xia Sun, Jie Li, Jie Wang, Hui Jin, Ling Wang, Feng-Min Lu, Tong Li, Ling Yan, Jing-Xian Yang, Mi-Shu Sun, Hui Zhuang
Virology journal Vol. 9 p. 121-121 2012/06/19 Research paper (scientific journal)
炎症と免疫 (vol.31 no.5(2023年9月号))
金暉, 荒瀬尚
先端医学社 2023/08/29
ISBN: 4865506063
ポストGWAS時代の遺伝統計学 : オミクス解析と機械学習でヒト疾患を俯瞰する
金 暉, 荒瀬 尚
実験医学増刊 Vol.41 No.7（羊土社） 2023/04
ISBN: 9784758104104
自己免疫疾患 : 層別化する新時代へ : 臨床検体のマルチオミクス解析、腸内細菌によって見えてきた免疫経路の全容
金 暉, 荒瀬 尚
実験医学増刊 Vol.40 No.15（羊土社） 2022/09
ISBN: 9784758104050
Abrogation of self-tolerance by self-antigen complexed with MHC class II molecules
Hui Jin, Hisashi Arase
第51回日本免疫学会学術集会 2022/12/08
ネオ・セルフによる⾃己免疫疾患の発症機構
Hui Jin
新学術領域研究「ネオ・ セルフの生成・機能・構造」第3回若手の会 2020/01/11
TSHR / MHC class II complexes are involved in the pathogenesis of Graves’ disease
Hui Jin, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
The 18th Awaji International Forum on Infection and Immunity 2019/09
グレーブス病⾃己抗体の標的であるTSH-R/MHCクラスIIネオ・セルフ複合体
Hui Jin
新学術領域研究「ネオ・ セルフの生成・機能・構造」第2回若手の会 2019/01/10
TSHR-stimulating autoantibody production by TSHR / MHC class II complexes
Hui Jin, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
第47回日本免疫学会学術集会 2018/12/12
TSH receptor/MHC class II neo-self complexes are involved in Graves’ disease as autoantibody targets
Hui Jin, Noriko Arase, Sumiko Matsuoka, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
第27回Kyoto T cell Conference 2017/03
Neo-self IgG/HLA-DR Complexes are Involved in Rheumatoid Arthritis Susceptibility as Autoantibody Targets
Hui Jin, Noriko Arase, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Kenji Tanimura, Ryosuke Hiwa, Lewis L. Lanier, Hisashi Arase
The 6th NIF Winter School on Advanced Immunology 2017/01
Induction of autoantibody by neo-self TSH receptor / MHC class II complexes
Hui Jin, Noriko Arase, Sumiko Matsuoka, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
第45回日本免疫学会学術集会 2016/12
Neo-self IgG/HLA-DR complexes are involved in RA susceptibility as autoantibody targets
Hui Jin
13th International Workshop on Autoantibodies and Autoimmunity 2016/10
Cellular misfolded proteins rescued from degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases
Hui Jin, Kenji Tanimura, Noriko Arase, Lewis L. Lanier, Hisashi Arase
16th International Congress of Immunology 2016/08
MHC class II molecules expose autoantibody epitopes on autoantigens
Hui Jin, Noriko Arase, Sumiko Matsuoka, Tadahiro Suenaga, Kouyuki Hirayasu, Masako Kohyama, Takehiko Sasazuki, Hisashi Arase
第44回日本免疫学会学術集会 2015/11/20
Cellular misfolded IgG heavy chain rescued from protein degradation by MHC class II molecules are targets for autoantibodies in rheumatoid arthritis
Hui Jin, Lewis L. Lanier, Hisashi Arase
The 4th CSI/JSI/KAI Joint Symposium on Immunology 2015/09/20
Cellular Misfolded Proteins Rescued from Protein Degradation by MHC Class II Molecules Are Targets for Autoantibodies in Autoimmune Diseases
Hui Jin, Lewis L. Lanier, Hisashi Arase
Keystone Symposia on Autoimmunity and Tolerance 2015/02/04
MHC class II-restricted recognition of self-antigen/MHC class II complexes by autoantibodies
Hui Jin, Noriko Arase, Sumiko Matsuoka, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Yuji Nakamaru, Yoshinori Iwatani, Takehiko Sasazuki, Ichiro Katayama, Hisashi Arase
第43回日本免疫学会学術集会 2014/12/10
Autoantibodies in Rheumatoid Arthritis Specifically Recognize IgG Heavy Chain Complexed with HLA-DR, Which is Strongly Associated with Rheumatoid Arthritis Susceptibility
Hui Jin, Noriko Arase, Kouyuki Hirayasu, Masako Kohyama, Tadahiro Suenaga, Fumiji Saito, Kenji Tanimura, Sumiko Matsuoka, Kosuke Ebina, Kenrin Shi, Shinsuke Yasuda, Tetsuya Horita, Ryosuke Hiwa, Kiyoshi Takasugi, Koichiro Ohmura, Hideki Yoshikawa, Takashi Saito, Tatsuya Atsumi, Takehiko Sasazuki, Ichiro Katayama, Lewis L. Lanier, Hisashi Arase
The 15th Annual European Congress of Rheumatology EULAR 2014/06/13
MHC クラス II 分子によって細胞外へ輸送された細胞内ミスフォール ド蛋白質が自己抗体の標的分子である
金 暉, 荒瀬 規子, 平安 恒幸, 香山 雅子, 末永 忠広, 松岡 須美子, 斉藤 隆, Lewis L. Lanier, 荒瀬 尚
第24回Kyoto T cell Conference 2014/05/17
IgG heavy chain presented on HLA-DR is associated with rheumatoid arthritis susceptibility
Hui Jin, Noriko Arase, Masako Kohyama, Fumiji Saito, Kouyuki Hirayasu, Maki Matsumoto, Kyoko Shida, Tadahiro Suenaga, Takashi Saito, Ichiro Katayama, Lewis L. Lanier, Hisashi Arase
2013/12/13
