Dominant-negative variants in CBX1 cause a neurodevelopmental disorder.

Yukiko Kuroda, Aiko Iwata-Otsubo, Kerith-Rae Dias, Suzanna E L Temple, Koji Nagao, Lachlan De Hayr, Ying Zhu, Shin-Ya Isobe, Gohei Nishibuchi, Sarah K Fiordaliso, Yuki Fujita, Alyssa L Rippert, Samuel W Baker, Marco L Leung, Daniel C Koboldt, Adele Harman, Beth A Keena, Izumi Kazama, Gopinath Musuwadi Subramanian, Kandamurugu Manickam, Betsy Schmalz, Maeson Latsko, Elaine H Zackai, Matt Edwards, Carey-Anne Evans, Matthew C Dulik, Michael F Buckley, Toshihide Yamashita, W Timothy O'Brien, Robert J Harvey, Chikashi Obuse, Tony Roscioli, Kosuke Izumi

Genetics in medicine : official journal of the American College of Medical Genetics　Vol. 25　No. 7　p. 100861-100861　2023/07　Research paper (scientific journal)

Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.

Osamu Masui, Catherine Corbel, Koji Nagao, Takaho A Endo, Fuyuko Kezuka, Patricia Diabangouaya, Manabu Nakayama, Mami Kumon, Yoko Koseki, Chikashi Obuse, Haruhiko Koseki, Edith Heard

Nature cell biology　Vol. 25　No. 1　p. 134-144　2023/01　Research paper (scientific journal)

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi

Communications Biology　Vol. 5　No. 1　2022/12/28　Research paper (scientific journal)

SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice

Saya Ichihara, Koji Nagao, Takehisa Sakaguchi, Chikashi Obuse, Takashi Sado

Development　2022/08/01　Research paper (scientific journal)

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action.

Shin-Ya Isobe, Shin-Ichiro Hiraga, Koji Nagao, Hiroyuki Sasanuma, Anne D Donaldson, Chikashi Obuse

Cell reports　Vol. 36　No. 2　p. 109383-109383　2021/07/13　Research paper (scientific journal)

Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing.

Hisashi Miura, Saori Takahashi, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Katsuzumi Okumura, Masato Ogata, Ichiro Hiratani, Shin-Ichiro Takebayashi

Nature protocols　Vol. 15　No. 12　p. 4058-4100　2020/12　Research paper (scientific journal)

Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency

Kenichi Kinjo, Keisuke Nagasaki, Koji Muroya, Erina Suzuki, Keisuke Ishiwata, Kazuhiko Nakabayashi, Atsushi Hattori, Koji Nagao, Ryu-Suke Nozawa, Chikashi Obuse, Kenji Miyado, Tsutomu Ogata, Maki Fukami, Mami Miyado

Scientific Reports　Vol. 10　No. 1　p. 10985-10985　2020/12　Research paper (scientific journal)

Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy.

Kohei Hamanaka, Darina Šikrová, Satomi Mitsuhashi, Hiroki Masuda, Yukari Sekiguchi, Atsuhiko Sugiyama, Kazumoto Shibuya, Richard J L F Lemmers, Remko Goossens, Megumu Ogawa, Koji Nagao, Chikashi Obuse, Satoru Noguchi, Yukiko K Hayashi, Satoshi Kuwabara, Judit Balog, Ichizo Nishino, Silvère M van der Maarel

Neurology　Vol. 94　No. 23　2020/06/09　Research paper (scientific journal)

Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast

Haruhiko Asakawa, Gregory P. Copenhaver, Tomoko Kojidani, Hui-Ju Yang, Chizuru Ohtsuki, Hiroko Osakada, Atsushi Matsuda, Masaaki Iwamoto, Yuji Chikashige, Koji Nagao, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi

PLOS Genetics　Vol. 15　No. 6　2019/06/06　Research paper (scientific journal)

Genome-wide stability of the DNA replication program in single mammalian cells.

Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin-Ichiro Takebayashi, Ichiro Hiratani

Nature genetics　Vol. 51　No. 3　p. 529-540　2019/03　Research paper (scientific journal)

Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice.

Sakakibara Y, Nagao K, Blewitt M, Sasaki H, Obuse C, Sado T

Development (Cambridge, England)　2018/09

Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1

Riki Terui, Koji Nagao, Yoshitaka Kawasoe, Kanae Taki, Torahiko L. Higashi, Seiji Tanaka, Takuro Nakagawa, Chikashi Obuse, Hisao Masukata, Tatsuro S. Takahashi

Genes and Development　Vol. 32　No. 11-12　p. 806-821　2018/06/01　Research paper (scientific journal)

分裂酵母に特異的な核膜孔複合体の構造

淺川 東彦, 糀谷 知子, Yang Hui-Ju, 小坂田 裕子, 大槻 千鶴, 長尾 恒治, 小布施 力史, 平岡 泰, 原口 徳子

生命科学系学会合同年次大会　Vol. 2017年度　p. [4LT18-0283)]　2017/12

Defects in dosage compensation impact global gene regulation in the mouse trophoblast

Yuka Sakata, Koji Nagao, Yuko Hoki, Hiroyuki Sasaki, Chikashi Obuse, Takashi Sado

DEVELOPMENT　Vol. 144　No. 15　p. 2784-2797　2017/08　Research paper (scientific journal)

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

Shin-Ya Isobe, Koji Nagao, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse

CELL REPORTS　Vol. 20　No. 2　p. 297-307　2017/07　Research paper (scientific journal)

Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliate Tetrahymena

Masaaki Iwamoto, Hiroko Osakada, Chie Mori, Yasuhiro Fukuda, Koji Nagao, Chikashi Obuse, Yasushi Hiraoka, Tokuko Haraguchi

JOURNAL OF CELL SCIENCE　Vol. 130　No. 10　p. 1822-1834　2017/05　Research paper (scientific journal)

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T. Kanemaki, Chikashi Obuse, Eiji Hara

NATURE COMMUNICATIONS　Vol. 8　2017/05　Research paper (scientific journal)

Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.

Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi

Scientific reports　Vol. 7　No. 1　p. 55-55　2017/03/03　Research paper (scientific journal)

CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe

Haruna Inoue, Shizuka Sugimoto, Yumiko Takeshita, Miho Takeuchi, Mitsuko Hatanaka, Koji Nagao, Takeshi Hayashi, Aya Kokubu, Mitsuhiro Yanagida, Junko Kanoh

GENES TO CELLS　Vol. 22　No. 1　p. 59-70　2017/01　Research paper (scientific journal)

"Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations" (vol 26, pg 300, 2016)

Kohei Hamanaka, Kanako Goto, Mami Arai, Koji Nagao, Chikashi Obuse, Satoru Noguchi, Yukiko K. Hayashi, Satomi Mitsuhashi, Ichizo Nishino

NEUROMUSCULAR DISORDERS　Vol. 26　No. 7　p. 472-472　2016/07

Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast

Shota Suzuki, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Yasushi Hiraoka, Hiroshi Kimura, Koji Nagao, Chikashi Obuse, Shinya Takahata, Yota Murakami

NUCLEIC ACIDS RESEARCH　Vol. 44　No. 9　p. 4147-4162　2016/05　Research paper (scientific journal)

Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations

Kohei Hamanaka, Kanako Goto, Mami Arai, Koji Nagao, Chikashi Obuse, Satoru Noguchi, Yukiko K. Hayashi, Satomi Mitsuhashi, Ichizo Nishino

NEUROMUSCULAR DISORDERS　Vol. 26　No. 4-5　p. 300-308　2016/04　Research paper (scientific journal)

Histone H4 lysine 20 acetylation is associated with gene repression in human cells

Jun-Ya Kaimori, Kazumitsu Maehara, Yoko Hayashi-Takanaka, Akihito Harada, Masafumi Fukuda, Satoko Yamamoto, Naotsugu Ichimaru, Takashi Umehara, Shigeyuki Yokoyama, Ryo Matsuda, Tsuyoshi Ikura, Koji Nagao, Chikashi Obuse, Naohito Nozaki, Shiro Takahara, Toshifumi Takao, Yasuyuki Ohkawa, Hiroshi Kimura, Yoshitaka Isaka

SCIENTIFIC REPORTS　Vol. 6　2016/04　Research paper (scientific journal)

Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex

Takeshi Hayashi, Masahiro Ebe, Koji Nagao, Aya Kokubu, Kenichi Sajiki, Mitsuhiro Yanagida

GENES TO CELLS　Vol. 19　No. 7　p. 541-554　2014/07　Research paper (scientific journal)

An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions

Nao Saito, Hongjiang Qiao, Teruki Yanagi, Satoru Shinkuma, Keiko Nishimura, Asuka Suto, Yasuyuki Fujita, Shotaro Suzuki, Toshifumi Nomura, Hideki Nakamura, Koji Nagao, Chikashi Obuse, Hiroshi Shimizu, Riichiro Abe

SCIENCE TRANSLATIONAL MEDICINE　Vol. 6　No. 245　2014/07　Research paper (scientific journal)

A novel method for purification of the endogenously expressed fission yeast Set2 complex

Shota Suzuki, Koji Nagao, Chikashi Obuse, Yota Murakami, Shinya Takahata

PROTEIN EXPRESSION AND PURIFICATION　Vol. 97　p. 44-49　2014/05　Research paper (scientific journal)

The 3rd DBCLS BioHackathon: improving life science data integration with Semantic Web technologies

Toshiaki Katayama, Mark D. Wilkinson, Gos Micklem, Shuichi Kawashima, Atsuko Yamaguchi, Mitsuteru Nakao, Yasunori Yamamoto, Shinobu Okamoto, Kenta Oouchida, Hong-Woo Chun, Jan Aerts, Hammad Afzal, Erick Antezana, Kazuharu Arakawa, Bruno Aranda, Francois Belleau, Jerven Bolleman, Raoul J. P. Bonnal, Brad Chapman, Peter J. A. Cock, Tore Eriksson, Paul M. K. Gordon, Naohisa Goto, Kazuhiro Hayashi, Heiko Horn, Ryosuke Ishiwata, Eli Kaminuma, Arek Kasprzyk, Hideya Kawaji, Nobuhiro Kido, Young Joo Kim, Akira R. Kinjo, Fumikazu Konishi, Kyung-Hoon Kwon, Alberto Labarga, Anna-Lena Lamprecht, Yu Lin, Pierre Lindenbaum, Luke McCarthy, Hideyuki Morita, Katsuhiko Murakami, Koji Nagao, Kozo Nishida, Kunihiro Nishimura, Tatsuya Nishizawa, Soichi Ogishima, Keiichiro Ono, Kazuki Oshita, Keun-Joon Park, Pjotr Prins, Taro L. Saito, Matthias Samwald, Venkata P. Satagopam, Yasumasa Shigemoto, Richard Smith, Andrea Splendiani, Matthias Samwald, Venkata P. Satagopam, Yasumasa Shigemoto, Richard Smith, Andrea Splendiani, Hideaki Sugawara, James Taylor, Rutger A. Vos, David Withers, Chisato Yamasaki, Christian M. Zmasek, Shoko Kawamoto, Kosaku Okubo, Kiyoshi Asai, Toshihisa Takagi

JOURNAL OF BIOMEDICAL SEMANTICS　Vol. 4　2013/02

Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway

Ryu-Suke Nozawa, Koji Nagao, Ken-Taro Igami, Sachiko Shibata, Natsuko Shirai, Naohito Nozaki, Takashi Sado, Hiroshi Kimura, Chikashi Obuse

Nature Structural and Molecular Biology　Vol. 20　No. 5　p. 566-573　2013　Research paper (scientific journal)

A co-localization model of paired ChIP-seq data using a large ENCODE data set enables comparison of multiple samples

Kazumitsu Maehara, Jun Odawara, Akihito Harada, Tomohiko Yoshimi, Koji Nagao, Chikashi Obuse, Koichi Akashi, Taro Tachibana, Toshio Sakata, Yasuyuki Ohkawa

NUCLEIC ACIDS RESEARCH　Vol. 41　No. 1　p. 54-62　2013/01　Research paper (scientific journal)

Prerequisite of sample preparatin for identification of components of a protein complex

NAGAO Koji, NOZAWA Ryu-Suke, OBUSE Chikashi

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2012　p. 78-78　2012

CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast

Masayoshi Fukuura, Koji Nagao, Chikashi Obuse, Tatsuro S. Takahashi, Takuro Nakagawa, Hisao Masukata

MOLECULAR BIOLOGY OF THE CELL　Vol. 22　No. 14　p. 2620-2633　2011/07　Research paper (scientific journal)

Human POGZ modulates dissociation of HP1 alpha from mitotic chromosome arms through Aurora B activation

Ryu-Suke Nozawa, Koji Nagao, Hiro-Taka Masuda, Osamu Iwasaki, Toru Hirota, Naohito Nozaki, Hiroshi Kimura, Chikashi Obuse

NATURE CELL BIOLOGY　Vol. 12　No. 7　p. 719-U212　2010/07　Research paper (scientific journal)

Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast

Kojiro Takeda, Tomoko Yoshida, Sakura Kikuchi, Koji Nagao, Aya Kokubu, Tomas Pluskal, Alejandro Villar-Briones, Takahiro Nakamura, Mitsuhiro Yanagida

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 107　No. 8　p. 3540-3545　2010/02　Research paper (scientific journal)

Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor

Yuichiro Hanyu, Kumiko K. Imai, Yosuke Kawasaki, Takahiro Nakamura, Yukinobu Nakaseko, Koji Nagao, Aya Kokubu, Masahiro Ebe, Asuka Fujisawa, Takeshi Hayashi, Chikashi Obuse, Mitsuhiro Yanagida

GENES TO CELLS　Vol. 14　No. 5　p. 539-554　2009/05　Research paper (scientific journal)

Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin

Yuu Kimata, Akihisa Matsuyama, Koji Nagao, Kanji Furuya, Chikashi Obuse, Minoru Yoshida, Mitsuhiro Yanagida

JOURNAL OF CELL SCIENCE　Vol. 121　No. 7　p. 1107-1118　2008/04　Research paper (scientific journal)

Cut1/separase-dependent roles of multiple phosphorylation of fission yeast Cohesion subunit Rad21 in post-replicative damage repair and mitosis

Yoh Adachi, Aya Kokubu, Masahiro Ebe, Koji Nagao, Mitsuhiro Yanagida

CELL CYCLE　Vol. 7　No. 6　p. 765-776　2008/03　Research paper (scientific journal)

Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis

Norihiko Nakazawa, Takahiro Nakamura, Aya Kokubu, Masahiro Ebe, Koji Nagao, Mitsuhiro Yanagida

JOURNAL OF CELL BIOLOGY　Vol. 180　No. 6　p. 1115-1131　2008/03　Research paper (scientific journal)

Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits

Takeshi Hayashi, Mitsuko Hatanaka, Koji Nagao, Yukinobu Nakaseko, Junko Kanoh, Aya Kokubu, Masahiro Ebe, Mitsuhiro Yanagida

GENES TO CELLS　Vol. 12　No. 12　p. 1357-1370　2007/12　Research paper (scientific journal)

Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombe

Mizuki Shimanuki, Soo-Yoel Chung, Yuji Chikashige, Yosuke Kawasaki, Lisa Uehara, Chihiro Tsutsumi, Mitsuko Hatanaka, Yasushi Hiraoka, Koji Nagao, Mitsuhiro Yanagida

GENES TO CELLS　Vol. 12　No. 5　p. 677-692　2007/05　Research paper (scientific journal)

Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses

Yosuke Kawasaki, Koji Nagao, Takahiro Nakamura, Mitsuhiro Yanagida

CELL CYCLE　Vol. 5　No. 16　p. 1831-1839　2006/08　Research paper (scientific journal)

Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase

K Nagao, M Yanagida

GENES TO CELLS　Vol. 11　No. 3　p. 247-260　2006/03　Research paper (scientific journal)

An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation

T Yuasa, T Hayashi, N Ikai, T Katayama, K Aoki, T Obara, Y Toyoda, T Maruyama, D Kitagawa, K Takahashi, K Nagao, Y Nakaseko, M Yanagida

GENES TO CELLS　Vol. 9　No. 11　p. 1069-1082　2004/11　Research paper (scientific journal)

Separase-mediated cleavage of cohesin at interphase is required for DNA repair

K Nagao, Y Adachi, M Yanagida

NATURE　Vol. 430　No. 7003　p. 1044-1048　2004/08　Research paper (scientific journal)

Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation

T Nakamura, K Nagao, Y Nakaseko, M Yanagida

GENES TO CELLS　Vol. 7　No. 11　p. 1113-1124　2002/11　Research paper (scientific journal)

Requirement of chromatid cohesion proteins Rad21/Scc1 and Mis4/Scc2 for normal spindle-kinetochore interaction in fission yeast

Y Toyoda, K Furuya, G Goshima, K Nagao, K Takahashi, M Yanagida

CURRENT BIOLOGY　Vol. 12　No. 5　p. 347-358　2002/03　Research paper (scientific journal)

Regulating sister chromatid separation by separase phosphorylation

K Nagao, M Yanagida

DEVELOPMENTAL CELL　Vol. 2　No. 1　p. 2-4　2002/01

Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase

T Tomonaga, K Nagao, Y Kawasaki, K Furuya, A Murakami, J Morishita, T Yuasa, T Sutani, SE Kearsey, F Uhlmann, K Nasmyth, M Yanagida

GENES & DEVELOPMENT　Vol. 14　No. 21　p. 2757-2770　2000/11　Research paper (scientific journal)

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis

K Kumada, T Nakamura, K Nagao, H Funabiki, T Nakagawa, M Yanagida

CURRENT BIOLOGY　Vol. 8　No. 11　p. 633-641　1998/05　Research paper (scientific journal)

Fission yeast Cut2 required for anaphase has two destruction boxes

H Funabiki, H Yamano, K Nagao, H Tanaka, H Yasuda, T Hunt, M Yanagida

EMBO JOURNAL　Vol. 16　No. 19　p. 5977-5987　1997/10　Research paper (scientific journal)

Cut2 proteolysis required for sister-chromatid separation in fission yeast

H Funabiki, H Yamano, K Kumada, K Nagao, T Hunt, M Yanagida

NATURE　Vol. 381　No. 6581　p. 438-441　1996/05　Research paper (scientific journal)