JAICI賞
一般財団法人化学情報協会 2025/04
日本薬学会奨励賞
2025/03
大阪大学賞（若手教員部門）
2024/11
日本薬学会関西支部奨励賞
2023/11
Ohtsuka Award
(The Japan Society of Nucleic Acids Chemistry) 2022/11
Effects of acid-mediated deamination of cytidine and 5-methylcytidine on solid-phase synthesis of oligonucleotides
Yusuke Isono, Chihiro Karasugi, Takuya Akisawa, Takashi Osawa, Qin Ren, Michiaki Tatsuno, Fumi Ito, Takao Inoue, Junji Kawakami, Satoshi Obika, Masaki Shinoda
Tetrahedron Vol. 185 2025/07 Research paper (scientific journal)
Publisher: Elsevier BV
Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects
Tomoaki Hara, Sikun Meng, Yuuya Kasahara, Takashi Osawa, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Saito, Kana Inoue, Yumiko Hamano, Yuichiro Doki, Hidetoshi Eguchi, Satoshi Obika, Hideshi Ishii
Molecular Therapy Nucleic Acids 2025/04 Research paper (scientific journal)
Publisher: Elsevier BV
Synthesis and structural analysis of dinucleotides containing 2′,3′-trans-bridged nucleic acids with trans-5,6- or 5,7-fused ring skeleton
Takashi Osawa, Ryota Nakanishi, Keito Uda, So Muramoto, Satoshi Obika
Communications Chemistry Vol. 8 No. 1 2025/03/22 Research paper (scientific journal)
Publisher: Springer Science and Business Media LLC
Synthesis of Coumarin-oligonucleiotide Conjugates for Application in DNA-encoded Libraries
Takashi Osawa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN Vol. 144 No. 10 p. 931-936 2024/10
In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity
Takashi Osawa, Ryosuke Kita, Yuuya Kasahara, Harumi Yamaguma, Taisuke Nakayama, Haruhiko Kamada, Satoshi Obika
Bioorganic & Medicinal Chemistry Vol. 110 2024/08/01 Research paper (scientific journal)
THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides
Qin Ren, Takashi Osawa, Michiaki Tatsuno, Satoshi Obika
RSC Advances Vol. 14 No. 30 p. 21590-21596 2024/07/08 Research paper (scientific journal)
Light-controllable cell-membrane disturbance for intracellular delivery.
Wenting Huo, Koji Miki, Huiying Mu, Takashi Osawa, Harumi Yamaguma, Yuuya Kasahara, Satoshi Obika, Yoshimasa Kawaguchi, Hisaaki Hirose, Shiroh Futaki, Yusuke Miyazaki, Wataru Shinoda, Shuji Akai, Kouichi Ohe
Journal of materials chemistry. B 2024/05/07 Research paper (scientific journal)
Synthesis of Coumarin-Conjugated Oligonucleotides via Knoevenagel Condensation to Prepare an Oligonucleotide Library
Takashi Osawa, Satoshi Obika
Chemical and Pharmaceutical Bulletin Vol. 74 No. 2 p. 143-148 2024/02/01 Research paper (scientific journal)
Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3',4'-Tetrahydropyran-Bridged Nucleic Acid.
Takashi Osawa, Taiki Akino, Satoshi Obika
The Journal of organic chemistry Vol. 89 No. 1 p. 269-280 2024/01/05 Research paper (scientific journal)
Development of simple purification method for oligonucleotides synthesized using phosphoramidite for 5′-end modification as capping reagent
Qin Ren, Takashi Osawa, Satoshi Obika
Tetrahedron Vol. 150 2024/01 Research paper (scientific journal)
Publisher: Elsevier BVPost-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability.
Atsushi Mikami, Shohei Mori, Takashi Osawa, Satoshi Obika
Chemistry A European Journal Vol. 29 No. 63 2023/11/13 Research paper (scientific journal)
強塩基処理できないオリゴ核酸の3′-アミノリンカー修飾法の開発
大澤昂志
日本核酸化学会誌 No. 7 p. 3-8 2023/11
Comparison of Analysis Data of Model Oligonucleotide Therapeutics Obtained with Different Types of Liquid Chromatograph-Mass Spectrometers
廣瀬賢治, 吉田徳幸, 寺崎真樹, 瀬崎浩史, 唐澤薫, 岩崎了教, 高原健太郎, 滝口直美, 関口光明, 南海浩一, 斎藤恵美, 佐藤秀昭, 大澤昂志, 山口卓男, 伊藤浩介, 川上純司, 小比賀聡, 井上貴雄
医薬品医療機器レギュラトリーサイエンス Vol. 54 No. 5 2023
Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide
Taslima Rahman Chowdhury, Tahia Taufiq, Kenta Ishida, Md Ariful Islam, Yuuya Kasahara, Takashi Osawa, Satoshi Obika
Bioorganic & Medicinal Chemistry Vol. 78 2023/01 Research paper (scientific journal)
Publisher: Elsevier BV
Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End
Takashi Osawa, Qin Ren, Satoshi Obika
Molecules Vol. 27 No. 23 2022/12/03 Research paper (scientific journal)
Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides.
Ryohei Yamaji, Osamu Nakagawa, Yuki Kishimoto, Akane Fujii, Tomoki Matsumura, Taisuke Nakayama, Haruhiko Kamada, Takashi Osawa, Takao Yamaguchi, Satoshi Obika
Bioorganic & Medicinal Chemistry Vol. 72 p. 116972-116972 2022/10/15 Research paper (scientific journal)
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton.
Takashi Osawa, Natsumi Yano, Hiroshi Aoyama, Satoshi Obika
Chemical & Pharmaceutical Bulletin Vol. 70 No. 10 p. 699-706 2022/10 Research paper (scientific journal)
Synthesis and Properties of Oligonucleotides Containing 2'-O,4'-C-Methyleneoxy-Bridged Pyrimidine Derivatives.
Misa Shoji, Yasufumi Fuchi, Takashi Osawa, Han Kim, Yuta Ito, Yoshiyuki Hari
The Journal of Organic Chemistry Vol. 87 No. 17 p. 11743-11750 2022/09/02 Research paper (scientific journal)
Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
Ryosuke Kita, Takashi Osawa, Satoshi Obika
RSC Chemical Biology Vol. 3 No. 6 p. 728-738 2022/06 Research paper (scientific journal)
Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials.
Fahad Hussain, Fahad Imtiaz Rahman, Poushali Saha, Atsushi Mikami, Takashi Osawa, Satoshi Obika, S M Abdur Rahman
Molecules (Basel, Switzerland) Vol. 27 No. 11 2022/05/29 Research paper (scientific journal)
New Cleavable Spacers for Tandem Synthesis of Multiple Oligo-nucleotides
Kazuki Yamamoto, Yasufumi Fuchi, Masaya Okabe, Takashi Osawa, Yuta Ito, Yoshiyuki Hari
SYNTHESIS-STUTTGART 2021/06 Research paper (scientific journal)
The effect of the base triplets adjacent to A T•CG OR 5-methylc•CG triplet in the triplex DNA
Yuta Ito, Chisa Hama, Takashi Osawa, Yoshiyuki Hari
Heterocycles Vol. 103 No. 1 2021 Research paper (scientific journal)
Synthesis and properties of oligonucleotides bearing thymidine derivatives with 1,6-dioxaspiro[4.5]decane skeleton.
Takashi Osawa, Miho Kawaguchi, Ye-Jin Jang, Yuta Ito, Yoshiyuki Hari
Bioorganic & medicinal chemistry Vol. 31 2020/12/23 Research paper (scientific journal)
Synthesis of Oligonucleotides Containing 2'-N-alkylaminocarbonyl-2'-amino-LNA (2'-urea-LNA) Moieties Using Post-Synthetic Modification Strategy.
Shoko Yamashita, Kodai Nishida, Takashi Osawa, Ayumi Nakanishi, Yuta Ito, Yoshiyuki Hari
Molecules (Basel, Switzerland) Vol. 25 No. 2 2020/01/15
Synthesis and hybridizing property of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyadenosine with an exocyclic methylene unit
Osawa T, Onishi Y, Wakita S, Ito Y, Hari Y
Heterocycles Vol. 101 No. 1 p. 284-297 2020 Research paper (scientific journal)
Publisher: The Japan Institute of Heterocyclic Chemistry
Synthesis of 2'-C,4'-C-Methyleneoxy-Bridged Thymidine Derivatives and Properties of Modified Oligonucleotides.
Osawa T, Kim H, Shoji M, Saijo M, Dohi M, Ito Y, Obika S, Hari Y
The Journal of organic chemistry Vol. 84 No. 21 p. 13336-13342 2019/10 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
Synthesis of the Methyl Analog of 2'-O,4'-C-Ethylene-Bridged 5-Methyluridine via Intramolecular Radical Cyclization and Properties of Modified Oligonucleotides.
Ito Y, Tsutsui N, Osawa T, Hari Y
The Journal of organic chemistry Vol. 84 No. 14 p. 9093-9100 2019/07 Research paper (scientific journal)
Publisher: American Chemical Society (ACS)
SYNTHESIS AND HYBRIDIZATION PROPERTIES OF OLIGONUCLEOTIDES INCLUDING 2 '-N-ALKOXYCARBONYL-2 '-AMINO-LNA DERIVATIVES
Osawa Takashi, Yamashita Shoko, Nakanishi Ayumi, Ito Yuta, Hari Yoshiyuki
HETEROCYCLES Vol. 99 No. 1 p. 502-520 2019/04/01 Research paper (scientific journal)
2′-C,4′-C-Ethyleneoxy-Bridged 2′-Deoxyribonucleic Acids (EoDNAs) with thymine nucleobases: Synthesis, duplex-forming ability, and enzymatic stability
Takashi Osawa, Satoshi Obika, Yoshiyuki Hari
Methods in Molecular Biology Vol. 1973 p. 59-89 2019 Part of collection (book)
Post-synthetic modification of oligonucleotides containing 5-trifluoromethylpyrimidine bases
Ito Yuta, Matsuo Misaki, Yamamoto Kazuki, Yamashita Wakana, Osawa Takashi, Hari Yoshiyuki
TETRAHEDRON Vol. 74 No. 47 p. 6854-6860 2018/11/22 Research paper (scientific journal)
SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 3'-O,4'-C-ETHYLENEOXY-BRIDGED 5-METHYLURIDINES
Osawa Takashi, Hitomi Yuka, Wakita Sawako, Kim Han, Dohi Masakazu, Horiba Masahiko, Ito Yuta, Obika Satoshi, Hari Yoshiyuki
HETEROCYCLES Vol. 97 No. 1 p. 306-313 2018/09/18 Research paper (scientific journal)
Publisher: The Japan Institute of Heterocyclic Chemistry
Photoredox-Catalyzed Deformylative 1,4-Addition of 2 '-Deoxy-5 '-O-phthalimidonucleosides for Synthesis of 5 '-Carba Analogs of Nucleoside 5 '-Phosphates
Ito Yuta, Kimura Airi, Osawa Takashi, Hari Yoshiyuki
JOURNAL OF ORGANIC CHEMISTRY Vol. 83 No. 18 p. 10701-10708 2018/09 Research paper (scientific journal)
Synthesis and hybridizing properties of isoDNAs including 3′-O,4′-C-ethyleneoxy-bridged 5-methyluridine derivatives
Takashi Osawa, Yuka Hitomi, Sawako Wakita, Han Kim, Yuta Ito, Yoshiyuki Hari
Bioorganic and Medicinal Chemistry Vol. 26 No. 14 p. 3875-3881 2018 Research paper (scientific journal)
Triplex- and Duplex-Forming Abilities of Oligonucleotides Containing 2 '-Deoxy-5-trifluoromethyluridine and 2 '-Deoxy-5-trifluoromethylcytidine
Yuta Ito, Misaki Matsuo, Takashi Osawa, Yoshiyuki Hari
CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 65 No. 10 p. 982-988 2017/10 Research paper (scientific journal)
Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged thymidine derivatives
Takashi Osawa, Motoki Sawamura, Fumito Wada, Tsuyoshi Yamamoto, Satoshi Obika, Yoshiyuki Hari
ORGANIC & BIOMOLECULAR CHEMISTRY Vol. 15 No. 18 p. 3955-3963 2017/05 Research paper (scientific journal)
SYNTHESIS OF THE 5-METHYLURIDINE MONOMER OF 3 '-O,4 '-C-ETHYLENEOXY-BRIDGED NUCLEIC ACID
Takashi Osawa, Masakazu Dohi, Yuka Hitomi, Yuta Ito, Satoshi Obika, Yoshiyuki Hari
HETEROCYCLES Vol. 95 No. 1 p. 342-352 2017/01 Research paper (scientific journal)
Synthesis and properties of novel 2 '-C,4 '-C-ethyleneoxy-bridged 2 '-deoxyribonucleic acids with exocyclic methylene groups
Takashi Osawa, Satoshi Obika, Yoshiyuki Hari
ORGANIC & BIOMOLECULAR CHEMISTRY Vol. 14 No. 40 p. 9481-9484 2016/10 Research paper (scientific journal)
Synthesis and Properties of the 5-Methyluridine Derivative of 3,4-Dihydro-2H-pyran-Bridged Nucleic Acid (DpNA)
Takashi Osawa, Yoshiyuki Hari, Masakazu Dohi, Yuya Matsuda, Satoshi Obika
JOURNAL OF ORGANIC CHEMISTRY Vol. 80 No. 21 p. 10474-10481 2015/11 Research paper (scientific journal)
Synthesis and properties of thymidines with six-membered amide bridge
Yoshiyuki Hari, Takashi Osawa, Yutaro Kotobuki, Aiko Yahara, Ajaya R. Shrestha, Satoshi Obika
Bioorganic and Medicinal Chemistry Vol. 21 No. 14 p. 4405-4412 2013/07/15 Research paper (scientific journal)
Synthesis and Properties of 2 '-O,4 '-C-Ethyleneoxy Bridged 5-Methyluridine
Yoshiyuki Hari, Tomohiko Morikawa, Takashi Osawa, Satoshi Obika
ORGANIC LETTERS Vol. 15 No. 14 p. 3702-3705 2013/07 Research paper (scientific journal)
Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency
Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama, Satoshi Obika
CHEMBIOCHEM Vol. 13 No. 17 p. 2513-2516 2012/11 Research paper (scientific journal)
Synthesis and duplex-forming ability of oligonucleotides containing 4 '-carboxythymidine
Yoshiyuki Hari, Takashi Osawa, Satoshi Obika
ORGANIC & BIOMOLECULAR CHEMISTRY Vol. 10 No. 48 p. 9639-9649 2012 Research paper (scientific journal)
Synthesis and Properties of a Bridged Nucleic Acid with a Perhydro-1,2-oxazin-3-one Ring
Ajaya R. Shrestha, Yoshiyuki Hari, Aiko Yahara, Takashi Osawa, Satoshi Obika
JOURNAL OF ORGANIC CHEMISTRY Vol. 76 No. 24 p. 9891-9899 2011/12 Research paper (scientific journal)
未来の核酸医薬に貢献できる技術開発を目指して
大澤昂志
生産と技術 Vol. 77 No. 2 p. 57-59 2025/04
Sustainability in Tides Chemistry
Takashi Osawa, Satoshi Obika
Chapter 9: Oligonucleotide Synthesis and State-of-the-Art Drug Discovery p. 194-227 2024/10/18
Publisher: Royal Society of Chemistry
修飾核酸の合成
大澤昂志
核酸医薬〜モダリティ・合成・分析・DDSの最新動向〜 p. 67-74 2024/04
アンチセンス核酸およびsiRNA技術
大澤昂志, 小比賀聡
The Lipid Vol. 35 No. 1 p. 14-19 2024/04
核酸の分析
大澤昂志, 小比賀聡
医薬品開発のための分光法 p. 197-206 2022
Chemistry in oligonucleotide medicines
大澤昂志, 小比賀聡
Bio Clinica Vol. 36 No. 14 2021
糖部修飾核酸
大澤昂志, 小比賀聡
核酸化学ハンドブック p. 52-60 2020/12
P(V)の立体化学を精密に制御する メチルホスホナート修飾核酸の合成
大澤昂志
化学 Vol. 75 No. 9 p. 64-65 2020/09
The Development of Novel Six-Membered Bridged Nucleic Acids
10th Annual Meeting of the Oligonucleotide Therapeutics Society 2015
新規架橋型核酸3'-O,4'-C-エチレンオキシ-5-メチルウリジンの開発
日本薬学会第135回年会 2015
Synthesis and Property of a Novel 2’,4’-BNA Analog with 2,6-Dioxabicyclo-[3.2.1]-oct-3-ene Skeleton
The 40th International Symposium on Nucleic Acid Chemistry 2014
新規6員環架橋型チミジンを含むオリゴ核酸の合成および機能評価
第44回複素環化学討論会 2014
新規六員環架橋型核酸の合成およびその物性評価
第40回反応と合成の進歩シンポジウム 2014
Synthesis and duplex-forming ability of oligonucleotides containing 2'-substituted thymidines with carboxylic acid equivalents at the 4'-position
13th Tetrahedron Symposium 2013
2'-O,4'-C-エチレンオキシ架橋型5-メチルウリジンの合成と機能評価
第23回アンチセンスシンポジウム 2013
HxNA: A Bridged Nucleic Acid with a Perhydro-1,2-oxazin-3-one Ring
日本薬学会第132年会 2012
Development of a Novel Bridged Nucleic Acid Based on Intramolecular Hydrogen Bond Formation
The 7th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists 2012
分子内水素結合形成を基盤とした新規架橋型人工核酸の開発
日本薬学会第132年会 2012
6員環アミド架橋を有する新規人工核酸の合成及びその評価
アンチセンス・遺伝子・デリバリーシンポジウム2011 2011
アミド型6員環架橋構造を持つ新規人工核酸の合成と機能評価
第60回日本薬学会近畿支部大会総会 2010
架橋型ヌクレオシドおよびヌクレオチド
張 功幸, 小比賀 聡, 大澤 昂志
特許第6562517号
WO2016-017422
出願日:2015/07/14
登録日:2019/08/02
In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity
Osawa Takashi, Kita Ryosuke, Kasahara Yuuya, Yamaguma Harumi, Nakayama Taisuke, Kamada Haruhiko, Obika Satoshi
Bioorganic and Medicinal Chemistry Vol. 110 2024/08/01
Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid
Osawa Takashi, Akino Taiki, Obika Satoshi
Journal of Organic Chemistry Vol. 89 No. 1 p. 269-280 2024/01/05
新規六員環架橋型人工核酸の合成と物性に関する研究
大澤 昂志
