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Nagasawa Takashi

長澤　丘司

Graduate School of Frontier Biosciences　Department of Frontier Biosciences, Professor

keyword microenvironment，hematopoietic stem cell，niche，Chemokine，Cytokine，Hematopoiesis，immunology

Education

  • - 1993, Osaka University
  • - 1987, Nagoya University, School of Medicine

Research History

  • 2016 - Present, Osaka University, Graduate School of Frontier Biosciences
  • 2002 - 2015, Kyoto University, Institute for Frontier Medical Sciences
  • 1995 - 2002, Osaka Women's and Children's Hospital Research Institute

Research Areas

  • Life sciences, Hematology and oncology
  • Life sciences, Immunology
  • Life sciences, Developmental biology, stem cell biology

Professional Memberships

  • 日本骨免疫学会
  • 日本免疫学会

Papers

  • Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells, Yoshiki Omatsu,Shota Aiba,Tomonori Maeta,Kei Higaki,Kazunari Aoki,Hitomi Watanabe,Gen Kondoh,Riko Nishimura,Shu Takeda,Ung-il Chung,Takashi Nagasawa, Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1, 2022/05/12
  • MPN関連骨髄線維症においてCAR細胞より分化した線維芽細胞は造血幹細胞移植後早期にCXCL12産生能を回復する, 倉重 真沙子,杉山 立樹,大島 健司,田原 紳一郎,松井 崇浩,藤野 雅彦,伊藤 雅文,長澤 丘司,森井 英一, 日本病理学会会誌, (一社)日本病理学会, Vol. 111, No. 1, p. 251-251, 2022/03
  • Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness, Isringhausen S,Mun Y,Kovtonyuk L,Kräutler NJ,Suessbier U,Gomariz A,Spaltro G,Helbling PM,Wong HC,Nagasawa T,Manz MG,Oxenius A,Nombela-Arrieta C, Vol. 218, 2021/10
  • A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis, Nakagawa T,Jörg DJ,Watanabe H,Mizuno S,Han S,Ikeda T,Omatsu Y,Nishimura K,Fujita M,Takahashi S,Kondoh G,Simons BD,Yoshida S,Nagasawa T, Cell Reports, Vol. 37, No. 3, p. 109875-109875, 2021/10
  • Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions, Takao Sudo,Yasutaka Motomura,Daisuke Okuzaki,Tetsuo Hasegawa,Takafumi Yokota,Junichi Kikuta,Tomoka Ao,Hiroki Mizuno,Takahiro Matsui,Daisuke Motooka,Ryosuke Yoshizawa,Takashi Nagasawa,Yuzuru Kanakura,Kazuyo Moro,Masaru Ishii, Journal of Experimental Medicine, Rockefeller University Press, Vol. 218, No. 5, 2021/05/03
  • Identification of CXCL12-abundant reticular cells in human adult bone marrow, Aoki K,Kurashige M,Ichii M,Higaki K,Sugiyama T,Kaito T,Ando W,Sugano N,Sakai T,Shibayama H,HANDAI Clinical Blood Club,Takaori-Kondo A,Morii E,Kanakura Y,Nagasawa T, British journal of haematology, Vol. 193, No. 3, p. 659-668, 2021/05
  • A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration, Yuki Matsushita,Mizuki Nagata,Kenneth M. Kozloff,Joshua D. Welch,Koji Mizuhashi,Nicha Tokavanich,Shawn A. Hallett,Daniel C. Link,Takashi Nagasawa,Wanida Ono,Noriaki Ono, Nature Communications, Vol. 11, No. 1, 2020/12/01
  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis, Kiyoharu Fukushima,Takashi Satoh,Fuminori Sugihara,Yuki Sato,Toru Okamoto,Yuichi Mitsui,Sachiyo Yoshio,Songling Li,Satoshi Nojima,Daisuke Motooka,Shota Nakamura,Hiroshi Kida,Daron M. Standley,Eiichi Morii,Tatsuya Kanto,Motoko Yanagita,Yoshiharu Matsuura,Takashi Nagasawa,Atsushi Kumanogoh,Shizuo Akira, Immunity, Vol. 52, No. 3, p. 542-556.e13, 2020/03/17
  • Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene., Hisa Mukohira,Takahiro Hara,Shinya Abe,Shizue Tani-Ichi,Atsuko Sehara-Fujisawa,Takashi Nagasawa,Kazuyuki Tobe,Koichi Ikuta, International immunology, Vol. 31, No. 11, p. 729-742, 2019/10/16
  • Niches for hematopoietic stem cells and immune cell progenitors, Tatsuki Sugiyama,Yoshiki Omatsu,Takashi Nagasawa, International Immunology, Oxford University Press ({OUP}), 2018/08
  • Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2., Satoshi Koga,Katsuto Hozumi,Ken-Ichi Hirano,Masaki Yazawa,Tommy Terooatea,Aki Minoda,Takashi Nagasawa,Shigeo Koyasu,Kazuyo Moro, The Journal of Experimental Medicine, Vol. 215, No. 6, p. 1609-1626, 2018/06/04
  • Stem cell niche-specific Ebf3 maintains the bone marrow cavity, Masanari Seike,Yoshiki Omatsu,Hitomi Watanabe,Gen Kondoh,Takashi Nagasawa, Genes and Development, Cold Spring Harbor Laboratory Press, Vol. 32, No. 5-6, p. 359-372, 2018/03/01
  • Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4, Akihiro Shimba,Guangwei Cui,Shizue Tani-ichi,Makoto Ogawa,Shinya Abe,Fumie Okazaki,Satsuki Kitano,Hitoshi Miyachi,Hisakata Yamada,Takahiro Hara,Yasunobu Yoshikai,Takashi Nagasawa,Günther Schütz,Koichi Ikuta, Immunity, Elsevier BV, Vol. 48, No. 2, p. 286-298.e6, 2018/02
  • Dll4 and Notch signalling couples sprouting angiogenesis and artery formation, Mara E. Pitulescu,Inga Schmidt,Benedetto Daniele Giaimo,Tobiah Antoine,Frank Berkenfeld,Francesca Ferrante,Hongryeol Park,Manuel Ehling,Daniel Biljes,Susana F. Rocha,Urs H. Langen,Martin Stehling,Takashi Nagasawa,Napoleone Ferrara,Tilman Borggrefe,Ralf H. Adams, Nature Cell Biology, Nature Publishing Group, Vol. 19, No. 8, p. 915-927, 2017/08/01
  • Numerous niches for hematopoietic stem cells remain empty during homeostasis, Manabu Shimoto,Tatsuki Sugiyama,Takashi Nagasawa, Blood, AMER SOC HEMATOLOGY, Vol. 129, No. 15, p. 2124-2131, 2017/04
  • Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation, Ana Cordeiro Gomes,Takahiro Hara,Vivian Y. Lim,Dietmar Herndler-Brandstetter,Erin Nevius,Tatsuki Sugiyama,Shizue Tani-ichi,Susan Schlenner,Ellen Richie,Hans-Reimer Rodewald,Richard A. Flavell,Takashi Nagasawa,Koichi Ikuta,Joao Pedro Pereira, Immunity, CELL PRESS, Vol. 45, No. 6, p. 1219-1231, 2016/12
  • Phenotypic and morphological properties of germinal center dark zone Cxcl12-expressing reticular cells, Lauren B. Rodda,Oliver Bannard,Burkhard Ludewig,Takashi Nagasawa,Jason G. Cyster, Journal of Immunology, American Association of Immunologists, Vol. 195, No. 10, p. 4781-4791, 2015/11/15
  • CXCL12 catches T-ALL at the entrance of the bone marrow, Tatsuki Sugiyama,Takashi Nagasawa, Trends in Immunology, Elsevier Ltd, Vol. 36, No. 9, p. 504-506, 2015/09/01
  • The critical and specific transcriptional regulator of the microenvironmental niche for hematopoietic stem and progenitor cells, Yoshiki Omatsu,Takashi Nagasawa, Current Opinion in Hematology, Lippincott Williams and Wilkins, Vol. 22, No. 4, p. 330-336, 2015/07/01
  • Chemokine signaling controls integrity of radial glial scaffold in developing spinal cord and consequential proper position of boundary cap cells, Yan Zhu,Tomoko Matsumoto,Takashi Nagasawa,Fabienne Mackay,Fujio Murakami, Journal of Neuroscience, Society for Neuroscience, Vol. 35, No. 24, p. 9211-9224, 2015/06/17
  • Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice, Ryan B. Day,Deepta Bhattacharya,Takashi Nagasawa,Daniel C. Link, Blood, AMER SOC HEMATOLOGY, Vol. 125, No. 20, p. 3114-3117, 2015/05
  • Myeloid Cells Stimulate Their Progenitors in an Emergency, Tatsuki Sugiyama,Takashi Nagasawa, Immunity, Cell Press, Vol. 42, No. 1, p. 13-14, 2015/01/20
  • A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones, Noriaki Ono,Wanida Ono,Takashi Nagasawa,Henry M. Kronenberg, Nature Cell Biology, Nature Publishing Group, Vol. 16, No. 12, p. 1157-1167, 2014/12/01
  • 造血幹細胞を維持する骨髄のニッチ, 長澤 丘司,尾松 芳樹,杉山 立樹, 実験医学, Vol. 32, No. 16, p. 2543-2550, 2014/10
  • Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage, Noriaki Ono,Wanida Ono,Toshihide Mizoguchi,Takashi Nagasawa,Paul S. Frenette,Henry M. Kronenberg, Developmental Cell, Cell Press, Vol. 29, No. 3, p. 330-339, 2014/05/12
  • Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position, Daniel Vogt,Robert F. Hunt,Shyamali Mandal,Magnus Sandberg,Shanni N. Silberberg,Takashi Nagasawa,Zhengang Yang,Scott C. Baraban,John L.R. Rubenstein, Neuron, Cell Press, Vol. 82, No. 2, p. 350-364, 2014/04/16
  • Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation, Yoshiki Omatsu,Masanari Seike,Tatsuki Sugiyama,Tsutomu Kume,Takashi Nagasawa, Nature, NATURE PUBLISHING GROUP, Vol. 508, No. 7497, p. 536-+, 2014/04
  • Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection, Oliver Bannard,Robert M. Horton,Christopher D. C. Allen,Jinping An,Takashi Nagasawa,Jason G. Cyster, Immunity, CELL PRESS, Vol. 39, No. 5, p. 912-924, 2013/11
  • Neutrophil mobilization via plerixaformediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow, Sapna Devi,Yilin Wang,Weng Keong Chew,Ronald Lima,Noelia A-González,Citra N.Z. Mattar,Shu Zhen Chong,Andreas Schlitzer,Nadja Bakocevic,Samantha Chew,Jo L. Keeble,Chi Ching Goh,Jackson L.Y. Li,Maximilien Evrard,Benoit Malleret,Anis Larbi,Laurent Renia,Muzlifah Haniffa,Suet Mien Tan,Jerry K.Y. Chan,Karl Balabanian,Takashi Nagasawa,Françoise Bachelerie,Andrés Hidalgo,Florent Ginhoux,Paul Kubes,Lai Guan Ng, Journal of Experimental Medicine, Vol. 210, No. 11, p. 2321-2336, 2013/10
  • Establishment of a novel mouse model of ulcerative colitis with concomitant cytomegalovirus infection: in vivo identification of cytomegalovirus persistent infected cells., Kayoko Matsumura,Hiroshi Nakase,Isao Kosugi,Yusuke Honzawa,Takuya Yoshino,Minoru Matsuura,Hideya Kawasaki,Yoshifumi Arai,Toshihide Iwashita,Takashi Nagasawa,Tsutomu Chiba, Inflammatory bowel diseases, Vol. 19, No. 9, p. 1951-63, 2013/08
  • XRhythmic modulation of the hematopoietic niche through neutrophil clearance, María Casanova-Acebes,Christophe Pitaval,Linnea A. Weiss,César Nombela-Arrieta,Raphaël Chèvre,Noelia A-González,Yuya Kunisaki,Dachuan Zhang,Nico Van Rooijen,Leslie E. Silberstein,Christian Weber,Takashi Nagasawa,Paul S. Frenette,Antonio Castrillo,Andrés Hidalgo, Cell, Vol. 153, No. 5, p. X1025-1035, 2013/05/23
  • Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture, Reiko Nakagawa,Atsushi Togawa,Takashi Nagasawa,Shin-Ichi Nishikawa, Journal of Immunology, Vol. 190, No. 7, p. 3309-3318, 2013/04/01
  • CXCL12 in early mesenchymal progenitors is. required for haematopoietic stem-cell maintenance, Adam Greenbaum,Yen-Michael S. Hsu,Ryan B. Day,Laura G. Schuettpelz,Matthew J. Christopher,Joshua N. Borgerding,Takashi Nagasawa,Daniel C. Link, Nature, NATURE PUBLISHING GROUP, Vol. 495, No. 7440, p. 227-230, 2013/03
  • Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin, Wenling Li,Hiroshi Kohara,Yutaka Uchida,Jennifer M. James,Kosha Soneji,Darran G. Cronshaw,Yong-Rui Zou,Takashi Nagasawa,Yoh-suke Mukouyama, Developmental Cell, Vol. 24, No. 4, p. 359-371, 2013/02/25
  • A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure, Anna Aronovich,Yaniv Nur,Elias Shezen,Chava Rosen,Yael Zlotnikov Klionsky,Irit Milman,Liran Yarimi,David Hagin,Gidi Rechavi,Uriel Martinowitz,Takashi Nagasawa,Paul S. Frenette,Dalit Tchorsh-Yutsis,Yair Reisner, Blood, American Society of Hematology, Vol. 122, No. 15, p. 2562-2571, 2013
  • Spi-B is critical for plasmacytoid dendritic cell function and development, Izumi Sasaki,Katsuaki Hoshino,Takahiro Sugiyama,Chihiro Yamazaki,Takahiro Yano,Akihiko Iizuka,Hiroaki Hemmi,Takashi Tanaka,Masuyoshi Saito,Masanaka Sugiyama,Yuri Fukuda,Tomokazu Ohta,Katsuaki Sato,Akira Ainai,Tadaki Suzuki,Hideki Hasegawa,Noriko Toyama-Sorimachi,Hiroshi Kohara,Takashi Nagasawa,Tsuneyasu Kaisho, Blood, AMER SOC HEMATOLOGY, Vol. 120, No. 24, p. 4733-4743, 2012/12
  • Increased Susceptibility to Severe Chronic Liver Damage in CXCR4 Conditional Knock-Out Mice, Atsunori Tsuchiya,Michitaka Imai,Hiroteru Kamimura,Masaaki Takamura,Satoshi Yamagiwa,Tatsuki Sugiyama,Minoru Nomoto,Toshio Heike,Takashi Nagasawa,Tatsutoshi Nakahata,Yutaka Aoyagi, DIGESTIVE DISEASES AND SCIENCES, SPRINGER, Vol. 57, No. 11, p. 2892-2900, 2012/11
  • Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system, Chihiro Nishiyama,Toshihiro Uesaka,Takayuki Manabe,Yohei Yonekura,Takashi Nagasawa,Donald F. Newgreen,Heather M. Young,Hideki Enomoto, NATURE NEUROSCIENCE, NATURE PUBLISHING GROUP, Vol. 15, No. 9, p. 1211-U64, 2012/09
  • The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal, Takao Sudo,Takafumi Yokota,Kenji Oritani,Yusuke Satoh,Tatsuki Sugiyama,Tatsuro Ishida,Hirohiko Shibayama,Sachiko Ezoe,Natsuko Fujita,Hirokazu Tanaka,Tetsuo Maeda,Takashi Nagasawa,Yuzuru Kanakura, Journal of Immunology, Vol. 189, No. 1, p. 200-210, 2012/07/01
  • Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration, Ayako Nakamura-Ishizu,Yuji Okuno,Yoshiki Omatsu,Keisuke Okabe,Junko Morimoto,Toshimitsu Uede,Takashi Nagasawa,Toshio Suda,Yoshiaki Kubota, BLOOD, AMER SOC HEMATOLOGY, Vol. 119, No. 23, p. 5429-5437, 2012/06
  • ニッシェによる組織幹細胞の維持, 長澤丘司,尾松芳樹,杉山立樹, 実験医学Vol. 30 No 10（増刊）,21－28（2012）, 2012
  • 造血幹細胞のニッシェと造血調節, 長澤丘司,尾松芳樹,杉山立樹, Anual Review 2012 血液 高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編 中外医学社1－8（2012）, 2012
  • Bone marrow niches for hematopoietic stem cells and immune cells, Tatsuki Sugiyama,Takashi Nagasawa, Inflammation and Allergy - Drug Targets, Bentham Science Publishers B.V., Vol. 11, No. 3, p. 201-206, 2012
  • Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells, Takashi Nagasawa,Yoshiki Omatsu,Tatsuki Sugiyama, Trends in Immunology, ELSEVIER SCI LTD, Vol. 32, No. 7, p. 315-320, 2011/07
  • Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero, Yoshiaki Kubota,Keiyo Takubo,Masanori Hirashima,Narihito Nagoshi,Kazuo Kishi,Yuji Okuno,Ayako Nakamura-Ishizu,Keigo Sano,Masato Murakami,Masatsugu Ema,Yoshiki Omatsu,Satoru Takahashi,Takashi Nagasawa,Masabumi Shibuya,Hideyuki Okano,Toshio Suda, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 208, No. 5, p. 949-960, 2011/05
  • Emergency Evacuation! Hematopoietic Niches Induce Cell Exit in Infection, Tatsuki Sugiyama,Takashi Nagasawa, Immunity, CELL PRESS, Vol. 34, No. 4, p. 463-465, 2011/04
  • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development, Yu Lei,Adiratna Mat Ripen,Naozumi Ishimaru,Izumi Ohigashi,Takashi Nagasawa,Lukas T. Jeker,Michael R. Bösl,Georg A. Holländer,Yoshio Hayashi,Rene De Waal Malefyt,Takeshi Nitta,Yousuke Takahama, Journal of Experimental Medicine, Vol. 208, No. 2, p. 383-394, 2011/02/14
  • CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice, Mamiko Noda,Yoshiki Omatsu,Tatsuki Sugiyama,Shinya Oishi,Nobutaka Fujii,Takashi Nagasawa, Blood, AMER SOC HEMATOLOGY, Vol. 117, No. 2, p. 451-458, 2011/01
  • CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin-, and neuropeptide y-expressing gabaergic interneurons, Daisuke H. Tanaka,Sakae Mikami,Takashi Nagasawa,Jun-Ichi Miyazaki,Kazunori Nakajima,Fujio Murakami, Cerebral Cortex, Vol. 20, No. 12, p. 2810-2817, 2010/12
  • DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4, Fumiyuki Sanematsu,Masanori Hirashima,Melanie Laurin,Ryosuke Takii,Akihiko Nishikimi,Keiko Kitajima,Guo Ding,Mamiko Noda,Yuzo Murata,Yoshihiko Tanaka,Sadahiko Masuko,Toshio Suda,Chikara Meno,Jean-Francois Cote,Takashi Nagasawa,Yoshinori Fukui, CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, Vol. 107, No. 9, p. 1102-1105, 2010/10
  • The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche, Yoshiki Omatsu,Tatsuki Sugiyama,Hiroshi Kohara,Gen Kondoh,Nobutaka Fujii,Kenji Kohno,Takashi Nagasawa, Immunity, CELL PRESS, Vol. 33, No. 3, p. 387-399, 2010/09
  • Bone marrow graft-versus-host disease: Early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation, Yusuke Shono,Satoshi Ueha,Yong Wang,Jun Abe,Makoto Kurachi,Yoshihiro Matsuno,Tatsuki Sugiyama,Takashi Nagasawa,Masahiro Imamura,Kouji Matsushima, Blood, Vol. 115, No. 26, p. 5401-5411, 2010/07/01
  • 幹細胞の維持と血管性ニッチ (特集 血管新生を制御する--いかに血管を作り,そして壊せるか), 長澤 丘司,尾松 芳樹,杉山 立樹, 細胞工学, Vol. 29, No. 11, p. 1082-1086, 2010
  • Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4, Michelle L. Janas,Gabriele Varano,Kristjan Gudmundsson,Mamiko Noda,Takashi Nagasawa,Martin Turner, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 207, No. 1, p. 247-261, 2010/01
  • The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature, Yoshitsugu Takabatake,Tatsuki Sugiyama,Hiroshi Kohara,Taiji Matsusaka,Hidetake Kurihara,Pandelakis A. Koni,Yasuyuki Nagasawa,Takayuki Hamano,Isao Matsui,Noritaka Kawada,Enyu Imai,Takashi Nagasawa,Hiromi Rakugi,Yoshitaka Isaka, Journal of the American Society of Nephrology, Vol. 20, No. 8, p. 1714-1723, 2009/08
  • SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation, Yan Zhu,Tomoto Matsumoto,Sakae Mikami,Takashi Nagasawa,Fujio Murakami, Development, Vol. 136, No. 11, p. 1919-1928, 2009/06/01
  • Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model, Toshiyuki Kitaori,Hiromu Ito,Edward M. Schwarz,Ryosuke Tsutsumi,Hiroyuki Yoshitomi,Shinya Oishi,Masakazu Nakano,Nobutaka Fujii,Takashi Nagasawa,Takashi Nakamura, Arthritis and Rheumatism, Vol. 60, No. 3, p. 813-823, 2009/03
  • Random walk behavior of migrating cortical interneurons in the marginal zone: Time-lapse analysis in flat-mount cortex, Daisuke H. Tanaka,Mitsutoshi Yanagida,Yan Zhu,Sakae Mikami,Takashi Nagasawa,Jun-Ichi Miyazaki,Yuchio Yanagawa,Kunihiko Obata,Fujio Murakami, Journal of Neuroscience, Vol. 29, No. 5, p. 1300-1311, 2009/02/04
  • Mechanism of primitive duct formation in the pancreas and submandibular glands: A role for SDF-1, Anne-Christine Hick,Jonathan M Van Eyll,Sabine Cordi,Céline Forez,Lara Passante,Hiroshi Kohara,Takashi Nagasawa,Pierre Vanderhaeghen,Pierre J Courtoy,Guy G Rousseau,Frédéric P Lemaigre,Christophe E Pierreux, BMC Developmental Biology, Vol. 9, No. 1, 2009
  • Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis., Sakae Mikami,Hiroshi Nakase,Shuji Yamamoto,Yasuhiro Takeda,Takuya Yoshino,Katushiro Kasahara,Satoru Ueno,Norimitsu Uza,Shinya Oishi,Nobutaka Fujii,Takashi Nagasawa,Tsutomu Chiba, The Journal of pharmacology and experimental therapeutics, Vol. 327, No. 2, p. 383-92, 2008/11
  • New niches for B cells, Takashi Nagasawa, Nature Immunology, NATURE PUBLISHING GROUP, Vol. 9, No. 4, p. 345-346, 2008/04
  • Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling, Hiroshi Kohara,Yoshiki Omatsu,Tatsuki Sugiyama,Marniko Noda,Nobutaka Fujii,Takashi Nagasawa, Blood, AMER SOC HEMATOLOGY, Vol. 110, No. 13, p. 4153-4160, 2007/12
  • The chemokine CXCL12 and regulation of HSC and B lymphocyte development in the bone marrow niche, Takashi Nagasawa, Advances in Experimental Medicine and Biology, Vol. 602, p. 69-75, 2007
  • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches, Tatsuki Sugiyama,Hiroshi Kohara,Mamiko Noda,Takashi Nagasawa, Immunity, CELL PRESS, Vol. 25, No. 6, p. 977-988, 2006/12
  • Microenvironmental niches in the bone marrow required for B-cell development, T Nagasawa, Nature Reviews Immunology, NATURE PUBLISHING GROUP, Vol. 6, No. 2, p. 107-116, 2006/02
  • A Cxcl12-Cxcr4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons, Lieberam, I,D Agalliu,T Nagasawa,J Ericson,TM Jessell, NEURON, CELL PRESS, Vol. 47, No. 5, p. 667-679, 2005/09
  • The role of CXCL12 in the organ-specific process of artery formation, T Ara,K Tokoyoda,R Okamoto,PA Koni,T Nagasawa, Blood, AMER SOC HEMATOLOGY, Vol. 105, No. 8, p. 3155-3161, 2005/04
  • Cellular niches controlling B lymphocyte behavior within bone marrow during development, K Tokoyoda,T Egawa,T Sugiyama,BI Choi,T Nagasawa, Immunity, CELL PRESS, Vol. 20, No. 6, p. 707-718, 2004/06
  • Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny, T Ara,K Tokoyoda,T Sugiyama,T Egawa,K Kawabata,T Nagasawa, Immunity, CELL PRESS, Vol. 19, No. 2, p. 257-267, 2003/08
  • CXCR4 regulates interneuron migration in the developing neocortex, RK Stumm,C Zhou,T Ara,F Lazarini,M Dubois-Dalcq,T Nagasawa,Hollt, V,S Schulz, JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, Vol. 23, No. 12, p. 5123-5130, 2003/06
  • A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo., Toshiaki Ara,Manami Itoi,Kenji Kawabata,Takeshi Egawa,Koji Tokoyoda,Tatsuki Sugiyama,Nobutaka Fujii,Takashi Amagai,Takashi Nagasawa, Journal of Immunology (Baltimore, Md. : 1950), Vol. 170, No. 9, p. 4649-55, 2003/05/01
  • Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons, Y Zhu,T Yu,XC Zhang,T Nagasawa,JY Wu,Y Rao, NATURE NEUROSCIENCE, NATURE AMERICA INC, Vol. 5, No. 8, p. 719-720, 2002/08
  • Paranodal junction formation and spermatogenesis require sulfoglycolipids, K Honke,Y Hirahara,J Dupree,K Suzuki,B Popko,K Fukushima,J Fukushima,T Nagasawa,N Yoshida,Y Wada,N Taniguchi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 99, No. 7, p. 4227-4232, 2002/04
  • The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor, T Egawa,K Kawabata,H Kawamoto,K Amada,R Okamoto,N Fujii,T Kishimoto,Y Katsura,T Nagasawa, Immunity, CELL PRESS, Vol. 15, No. 2, p. 323-334, 2001/08
  • Role of chemokine SDF-1/PBSF and its receptor CXCR4 in blood vessel development, Takashi Nagasawa, Annals of the New York Academy of Sciences, New York Academy of Sciences, Vol. 947, p. 112-116, 2001
  • A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis, T Nagasawa, INTERNATIONAL JOURNAL OF HEMATOLOGY, CARDEN JENNINGS PUBL CO LTD, Vol. 72, No. 4, p. 408-411, 2000/12
  • A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution, Kenji Kawabata,Miho Ujikawa,Takeshi Egawa,Hiroshi Kawamoto,Kazunobu Tachibana,Hisashi Iizasa,Yoshimoto Katsura,Tadamitsu Kishimoto,Takashi Nagasawa, Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 10, p. 5663-5667, 1999/05/11
  • A CXC chemokine SDF-1/PBSF: A ligand for a HIV coreceptor, CXCR4, Takashi Nagasawa,Kazunobu Tachibana,Kenji Kawabata, Advances in Immunology, Vol. 71, p. 211-228, 1999
  • Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice, T. Naka,T. Matsumoto,M. Narazaki,M. Fujimoto,Y. Morita,Y. Ohsawa,H. Saito,T. Nagasawa,Y. Uchiyama,T. Kishimoto, Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 95, No. 26, p. 15577-15582, 1998/12/22
  • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice, Qing Ma,Dan Jones,Paul R. Borghesani,Rosalind A. Segal,Takashi Nagasawa,Tadamitsu Kismimoto,Roderick T. Bronson,Timothy A. Springer, Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 16, p. 9448-9453, 1998/08/04
  • The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract, K Tachibana,S Hirota,H Iizasa,H Yoshida,K Kawabata,Y Kataoka,Y Kitamura,K Matsushima,N Yoshida,S Nishikawa,T Kishimoto,T Nagasawa, Nature, MACMILLAN MAGAZINES LTD, Vol. 393, No. 6685, p. 591-594, 1998/06
  • A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection, T Nagasawa,K Tachibana,T Kishimoto, SEMINARS IN IMMUNOLOGY, ACADEMIC PRESS LTD, Vol. 10, No. 3, p. 179-185, 1998/06
  • Large quantity production with extreme convenience of human SDF-1α and SDF-1β by a Sendai virus vector, Chikaya Moriya,Tatsuo Shioda,Kei Tashiro,Takashi Nagasawa,Masaya Ikegawa,Yukano Ohnishi,Atsushi Kato,Huiling Hu,Xiaomi Xin,Mohammad K. Hasan,Midori Maekawa,Yutaka Takebe,Yuko Sakai,Tasuku Honjo,Yoshiyuki Nagai, FEBS Letters, Vol. 425, No. 1, p. 105-111, 1998/03/20
  • A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection, T Murakami,T Nakajima,N Koyanagi,K Tachibana,N Fujii,H Tamamura,N Yoshida,M Waki,A Matsumoto,O Yoshie,T Kishimoto,N Yamamoto,T Nagasawa, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 186, No. 8, p. 1389-1393, 1997/10
  • CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry, K Tachibana,T Nakajima,A Sato,K Igarashi,H Shida,H Iizasa,N Yoshida,O Yoshie,T Kishimoto,T Nagasawa, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 185, No. 10, p. 1865-1870, 1997/05
  • Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin, Takashi Nagasawa,Toshihiro Nakajima,Kazunobu Tachibana,Hisashi Iizasa,Conrad C. Bleul,Osamu Yoshie,Kouji Matsushima,Nobuaki Yoshida,Timothy A. Springer,Tadamitsu Kishimoto, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 93, No. 25, p. 14726-14729, 1996/12/10
  • Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1, T Nagasawa,S Hirota,K Tachibana,N Takakura,S Nishikawa,Y Kitamura,N Yoshida,H Kikutani,T Kishimoto, Nature, MACMILLAN MAGAZINES LTD, Vol. 382, No. 6592, p. 635-638, 1996/08
  • GENERATION AND CHARACTERIZATION OF A MONOCLONAL-ANTIBODY THAT INHIBITS STROMAL CELL-DEPENDENT B-LYMPHOPOIESIS, T NAGASAWA,T KAISHO,T KISHIMOTO,H KIKUTANI, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 152, No. 6, p. 2788-2797, 1994/03
  • MOLECULAR-CLONING AND STRUCTURE OF A PRE-B-CELL GROWTH-STIMULATING FACTOR, T NAGASAWA,H KIKUTANI,T KISHIMOTO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 91, No. 6, p. 2305-2309, 1994/03
  • A STROMAL CELL-SPECIFIC MONOCLONAL-ANTIBODY AUGMENTS THE STROMAL CELL-DEPENDENT B-LYMPHOPOIESIS, T KAISHO,T NAGASAWA,T KISHIMOTO,H KIKUTANI, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 148, No. 4, p. 989-995, 1992/02

Misc.

  • CAR cell-derived fibroblasts regain CXCL12 production early after HSCT in MPN-related myelofibrosis, 倉重真沙子,杉山立樹,大島健司,田原紳一郎,松井崇浩,藤野雅彦,伊藤雅文,伊藤雅文,長澤丘司,森井英一, 日本病理学会会誌, Vol. 111, No. 1, 2022
  • Identification of microenvironmental niches for hematopoietic stem cells and lymphoid progenitors—bone marrow fibroblastic reticular cells with salient features, Yoshiki Omatsu,Yoshiki Omatsu,Takashi Nagasawa, International Immunology, Oxford University Press ({OUP}), Vol. 33, No. 12, p. 821-826, 2021/11/25
  • Cellular Niches for Hematopoietic Stem Cells and Lympho-Hematopoiesis in Bone Marrow During Homeostasis and Blood Cancers, Yoshiki Omatsu,Yoshiki Omatsu,Kei Higaki,Takashi Nagasawa, Current Topics in Microbiology and Immunology, Springer International Publishing, p. 33-54, 2021
  • 骨髄の病理とゲノム異常 造血幹細胞移植における骨髄再構築過程の病理 骨髄微小環境に着目して, 倉重 真沙子,伊藤 雅文,長澤 丘司,森井 英一, 日本病理学会会誌, (一社)日本病理学会, Vol. 109, No. 1, p. 211-211, 2020/03
  • Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas., Keisuke Omori,Nanae Nagata,Kaori Kurata,Yoko Fukushima,Erika Sekihachi,Nobutaka Fujii,Tomoko Namba-Hamano,Yoshitsugu Takabatake,Marcus Fruttiger,Takashi Nagasawa,Akiyoshi Uemura,Takahisa Murata, JCI insight, Vol. 3, No. 23, 2018/12/06
  • Resting zone of the growth plate houses a unique class of skeletal stem cells, Koji Mizuhashi,Wanida Ono,Yuki Matsushita,Naoko Sakagami,Akira Takahashi,Thomas L. Saunders,Takashi Nagasawa,Henry M. Kronenberg,Noriaki Ono, Nature, Vol. 563, No. 7730, p. 254-258, 2018/11/08
  • Role of CXCL12-Expressing Bone Marrow Populations in Leukemic Stem Cell Regulation, Puneet Agarwal,Hui Li,Andrew J. Paterson,Jianbo He,Takashi Nagasawa,Ravi Bhatia, BLOOD, AMER SOC HEMATOLOGY, Vol. 128, No. 22, 2016/12
  • Hematopoietic stem cell niches control multipotent progenitor differentiation, Joao P. Pereira,Vivian Lim,Ana Gomes,Takahiro Hara,Dietmar Herndler-Brandstetter,Richard A. Flavell,Takashi Nagasawa,Koichi Ikuta, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 196, 2016/05
  • Distinct Contributions By Perivascular Niche Cells in Hematopoietic Stem Cell Maintenance, Noboru Asada,Yuya Kunisaki,Takashi Nagasawa,Paul S. Frenette, BLOOD, AMER SOC HEMATOLOGY, Vol. 126, No. 23, 2015/12
  • Foxc1 plays an essential role for the hematopoietic stem cell niche formation and inhibition of adipogenesis in bone marrow, Vol. 41, No. 5, p. 390-397, 2015/11
  • CXCL12/SDF-1 and CXCR4, Takashi Nagasawa, Frontiers in Immunology, Frontiers Research Foundation, Vol. 6, 2015
  • CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4, Takashi Nagasawa, Journal of Molecular Medicine, Springer Verlag, Vol. 92, No. 5, p. 433-439, 2014
  • Regulation of immune cell production by bone marrow niches, Takashi Nagasawa, Seikagaku, Vol. 84, No. 3, p. 163-167, 2012
  • The Endothelial Antigen ESAM Monitors Reversible Conversion of Hematopoietic Stem Cells Between Dormancy and Self-Renewal, Takao Sudo,Takafumi Yokota,Tatsuki Sugiyama,Tatsuro Ishida,Yusuke Satoh,Kenji Oritani,Takashi Nagasawa,Yuzuru Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 118, No. 21, p. 1011-1012, 2011/11
  • C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells, Sachie Hiratsuka,Dan G. Duda,Yuhui Huang,Shom Goel,Tatsuki Sugiyama,Takashi Nagasawa,Dai Fukumura,Rakesh K. Jain, Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 1, p. 302-307, 2011/01/04
  • Niches for hematopoietic stem cell, Regenerative medicine, Vol. 8, No. 2, p. 148-155,136, 2009/05
  • Vascular or stromal niches for hematopoietic stem cell, Cell technology., Vol. 27, No. 7, p. 670-675, 2008/07
  • Hematopoietic stem cell niches and the chemokine CXCL12 (SDF-1/PBSF), Vol. 221, No. 7, p. 563-568, 2007/05/19
  • Role of CXCL12-CXCR4 chemokine signaling in the generation of plasma cytoid dendritic cells, Kohara H,Omatsu Y,Sugiyama T,Noda M,Nagasawa T, 第37 回日本免疫学会（2007.11.21．東京）, 2007
  • 造血幹細胞,リンパ球形成を支持する骨髄のニッチ細胞とケモカインCXCL12, 長澤丘司,杉山立樹, 第28 回日本 炎症・再生医学会シンポジウム（2007.8.2．東京）, 2007
  • Critical role of CXCL12-CXCR4 interaction in the pathophysiology of inflammatory bowel disease, Sakae Mikami,Hiroshi Nakase,Takashi Nagasawa,Tsutomu Chiba, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, BLACKWELL PUBLISHING, Vol. 21, p. A369-A369, 2006/11
  • Critical role of cxcl12-cxcr4 interaction in the pathophysiology of inflammatory bowel disease, Sakae Mikami,Hiroshi Nakase,Takashi Nagasawa,Tsutomu Chiba, GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 130, No. 4, p. A366-A366, 2006/04
  • CXCL12 による成熟顆粒球の動態制御とCXCL12 発現細胞, 三上栄,杉山立樹,小原洋志,千葉勉,長澤丘司, 第35回日本免疫学会総会・学術集会（2005. 12. 13－15．横浜）, 2005
  • 【ケモカイン・ケモカインレセプターをめぐって】 Tリンパ球発生におけるCXCL12及びCXCR4の役割, 長澤 丘司,荒 敏昭, 臨床免疫, (有)科学評論社, Vol. 40, No. 4, p. 379-385, 2003/10
  • Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1), Toshiaki Ara,Yuri Nakamura,Takeshi Egawa,Tatsuki Sugiyama,Kuniya Abe,Tadamitsu Kishimoto,Yasuhisa Matsui,Takashi Nagasawa, Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 9, p. 5319-5323, 2003/04/29
  • CXCR4 regulates migration of interneurons in the developing neocortex, RK Stumm,C Zhou,T Ara,T Nagasawa,S Schulz,Hollt, V, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, SPRINGER-VERLAG, Vol. 367, p. R18-R18, 2003/03

Awards

  • Japan Academy Prize, NAGASAWA Takashi, The Japan Academy, 2019
  • Takeda Prize for Medical Science, NAGASAWA Takashi, 2014
  • The Japanese Society for Immunology Prize, Takashi Nagasawa, 1998/12

Presentations

  • “Adipo-osteogenic progenitors function as niches for hematopoietic stem and progenitor cells in the \nmarrow”, T. Nagasawa, The 9th Nikko International Symposium 2012,（2012.10.12．Tochigi）, 2012/10/12
  • Bone inflammation, “Bone marrow niches for hematopoietic \nstem and progenitor cells”, Takashi Nagasawa, 第32回 日本炎症・再生医学会、シンポジウム（2011/06/03 国立京都国際会館 京都）, 2011/06/03
  • “Adipo-osteogenic progenitors constitute reticular niches for hematopoietic stem \nand progenitor cells”, T. Nagasawa, The 23th Korean Sciety of Bone Metabolism Autumn Scientific Congress, Satellite Symposium:Bone and Hematopoietic System.November 19, 2011, Seoul, Korea, 2011
  • The chemokine CXCL \n12 and niches for hematopoietic stem cells and immune cells”, T. Nagasawa, 14th International Congress of Immunology. Symposium : cellular trafficking.(August 24 (23－27), 2010, Kobe, Japan), 2010
  • “The chemokine CXCL12 and bone marrow \nniches for hematopoietic stem cells (HSCs) and immune cells.”, T. Nagasawa, 3rd International Conference on Osteoimmunology.(June 21－25, 2010, Fira, Santorini, Greece), 2010
  • Bone marrow niches for hematopoietic stem cells and the chemokine CXCL12, T. Nagasawa, 第71回日本血液学会学術集会 ASH-JSH Joint Symposium: Hematopoietic stem cell niche (2009.10.24．Kyoto, Japan）, 2009
  • The chemokine CXCL12 and regulation of HSC and B lymphocyte development in the bone marrow niche. : Aegean Conferences, Nagasawa T, 1st International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems（2006.5.28－6.2. Crete, Greece）, 2006
  • CXCL12 and regulation of HSC and B lymphocyte behavior during development, Nagasawa, T, Gordon Research Conference on Immunochemistry and Immunobiology（2005. 8. 7－12. Oxford, United Kingdom）, 2005