A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis

Nakagawa T, Jörg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons BD, Yoshida S, Nagasawa T

Cell Reports　Vol. 37　No. 3　p. 109875-109875　2021/10　Research paper (scientific journal)

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, Ryosuke Yoshizawa, Takashi Nagasawa, Yuzuru Kanakura, Kazuyo Moro, Masaru Ishii

Journal of Experimental Medicine　Vol. 218　No. 5　2021/05/03　Research paper (scientific journal)

Identification of CXCL12-abundant reticular cells in human adult bone marrow

Aoki K, Kurashige M, Ichii M, Higaki K, Sugiyama T, Kaito T, Ando W, Sugano N, Sakai T, Shibayama H, HANDAI Clinical Blood Club, Takaori-Kondo A, Morii E, Kanakura Y, Nagasawa T

British journal of haematology　Vol. 193　No. 3　p. 659-668　2021/05　Research paper (scientific journal)

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Yuki Matsushita, Mizuki Nagata, Kenneth M. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, Daniel C. Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono

Nature Communications　Vol. 11　No. 1　2020/12/01　Research paper (scientific journal)

Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis

Kiyoharu Fukushima, Takashi Satoh, Fuminori Sugihara, Yuki Sato, Toru Okamoto, Yuichi Mitsui, Sachiyo Yoshio, Songling Li, Satoshi Nojima, Daisuke Motooka, Shota Nakamura, Hiroshi Kida, Daron M. Standley, Eiichi Morii, Tatsuya Kanto, Motoko Yanagita, Yoshiharu Matsuura, Takashi Nagasawa, Atsushi Kumanogoh, Shizuo Akira

Immunity　Vol. 52　No. 3　p. 542-556.e13　2020/03/17　Research paper (scientific journal)

Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene.

Hisa Mukohira, Takahiro Hara, Shinya Abe, Shizue Tani-Ichi, Atsuko Sehara-Fujisawa, Takashi Nagasawa, Kazuyuki Tobe, Koichi Ikuta

International immunology　Vol. 31　No. 11　p. 729-742　2019/10/16　Research paper (scientific journal)

Niches for hematopoietic stem cells and immune cell progenitors

Tatsuki Sugiyama, Yoshiki Omatsu, Takashi Nagasawa

International Immunology　2018/08

Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2.

Satoshi Koga, Katsuto Hozumi, Ken-Ichi Hirano, Masaki Yazawa, Tommy Terooatea, Aki Minoda, Takashi Nagasawa, Shigeo Koyasu, Kazuyo Moro

The Journal of Experimental Medicine　Vol. 215　No. 6　p. 1609-1626　2018/06/04　Research paper (scientific journal)

Stem cell niche-specific Ebf3 maintains the bone marrow cavity

Masanari Seike, Yoshiki Omatsu, Hitomi Watanabe, Gen Kondoh, Takashi Nagasawa

Genes and Development　Vol. 32　No. 5-6　p. 359-372　2018/03/01　Research paper (scientific journal)

Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4

Akihiro Shimba, Guangwei Cui, Shizue Tani-ichi, Makoto Ogawa, Shinya Abe, Fumie Okazaki, Satsuki Kitano, Hitoshi Miyachi, Hisakata Yamada, Takahiro Hara, Yasunobu Yoshikai, Takashi Nagasawa, Günther Schütz, Koichi Ikuta

Immunity　Vol. 48　No. 2　p. 286-298.e6　2018/02　Research paper (scientific journal)

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

Mara E. Pitulescu, Inga Schmidt, Benedetto Daniele Giaimo, Tobiah Antoine, Frank Berkenfeld, Francesca Ferrante, Hongryeol Park, Manuel Ehling, Daniel Biljes, Susana F. Rocha, Urs H. Langen, Martin Stehling, Takashi Nagasawa, Napoleone Ferrara, Tilman Borggrefe, Ralf H. Adams

Nature Cell Biology　Vol. 19　No. 8　p. 915-927　2017/08/01　Research paper (scientific journal)

Numerous niches for hematopoietic stem cells remain empty during homeostasis

Manabu Shimoto, Tatsuki Sugiyama, Takashi Nagasawa

Blood　Vol. 129　No. 15　p. 2124-2131　2017/04　Research paper (scientific journal)

Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

Ana Cordeiro Gomes, Takahiro Hara, Vivian Y. Lim, Dietmar Herndler-Brandstetter, Erin Nevius, Tatsuki Sugiyama, Shizue Tani-ichi, Susan Schlenner, Ellen Richie, Hans-Reimer Rodewald, Richard A. Flavell, Takashi Nagasawa, Koichi Ikuta, Joao Pedro Pereira

Immunity　Vol. 45　No. 6　p. 1219-1231　2016/12　Research paper (scientific journal)

Phenotypic and morphological properties of germinal center dark zone Cxcl12-expressing reticular cells

Lauren B. Rodda, Oliver Bannard, Burkhard Ludewig, Takashi Nagasawa, Jason G. Cyster

Journal of Immunology　Vol. 195　No. 10　p. 4781-4791　2015/11/15　Research paper (scientific journal)

CXCL12 catches T-ALL at the entrance of the bone marrow

Tatsuki Sugiyama, Takashi Nagasawa

Trends in Immunology　Vol. 36　No. 9　p. 504-506　2015/09/01

The critical and specific transcriptional regulator of the microenvironmental niche for hematopoietic stem and progenitor cells

Yoshiki Omatsu, Takashi Nagasawa

Current Opinion in Hematology　Vol. 22　No. 4　p. 330-336　2015/07/01　Research paper (scientific journal)

Chemokine signaling controls integrity of radial glial scaffold in developing spinal cord and consequential proper position of boundary cap cells

Yan Zhu, Tomoko Matsumoto, Takashi Nagasawa, Fabienne Mackay, Fujio Murakami

Journal of Neuroscience　Vol. 35　No. 24　p. 9211-9224　2015/06/17　Research paper (scientific journal)

Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice

Ryan B. Day, Deepta Bhattacharya, Takashi Nagasawa, Daniel C. Link

Blood　Vol. 125　No. 20　p. 3114-3117　2015/05　Research paper (scientific journal)

Myeloid Cells Stimulate Their Progenitors in an Emergency

Tatsuki Sugiyama, Takashi Nagasawa

Immunity　Vol. 42　No. 1　p. 13-14　2015/01/20

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

Noriaki Ono, Wanida Ono, Takashi Nagasawa, Henry M. Kronenberg

Nature Cell Biology　Vol. 16　No. 12　p. 1157-1167　2014/12/01　Research paper (scientific journal)

造血幹細胞を維持する骨髄のニッチ

長澤 丘司, 尾松 芳樹, 杉山 立樹

実験医学　Vol. 32　No. 16　p. 2543-2550　2014/10　Research paper (scientific journal)

Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage

Noriaki Ono, Wanida Ono, Toshihide Mizoguchi, Takashi Nagasawa, Paul S. Frenette, Henry M. Kronenberg

Developmental Cell　Vol. 29　No. 3　p. 330-339　2014/05/12　Research paper (scientific journal)

Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position

Daniel Vogt, Robert F. Hunt, Shyamali Mandal, Magnus Sandberg, Shanni N. Silberberg, Takashi Nagasawa, Zhengang Yang, Scott C. Baraban, John L.R. Rubenstein

Neuron　Vol. 82　No. 2　p. 350-364　2014/04/16　Research paper (scientific journal)

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

Yoshiki Omatsu, Masanari Seike, Tatsuki Sugiyama, Tsutomu Kume, Takashi Nagasawa

Nature　Vol. 508　No. 7497　p. 536-+　2014/04　Research paper (scientific journal)

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

Oliver Bannard, Robert M. Horton, Christopher D. C. Allen, Jinping An, Takashi Nagasawa, Jason G. Cyster

Immunity　Vol. 39　No. 5　p. 912-924　2013/11　Research paper (scientific journal)

Neutrophil mobilization via plerixaformediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

Sapna Devi, Yilin Wang, Weng Keong Chew, Ronald Lima, Noelia A-González, Citra N.Z. Mattar, Shu Zhen Chong, Andreas Schlitzer, Nadja Bakocevic, Samantha Chew, Jo L. Keeble, Chi Ching Goh, Jackson L.Y. Li, Maximilien Evrard, Benoit Malleret, Anis Larbi, Laurent Renia, Muzlifah Haniffa, Suet Mien Tan, Jerry K.Y. Chan, Karl Balabanian, Takashi Nagasawa, Françoise Bachelerie, Andrés Hidalgo, Florent Ginhoux, Paul Kubes, Lai Guan Ng

Journal of Experimental Medicine　Vol. 210　No. 11　p. 2321-2336　2013/10　Research paper (scientific journal)

Establishment of a novel mouse model of ulcerative colitis with concomitant cytomegalovirus infection: in vivo identification of cytomegalovirus persistent infected cells.

Kayoko Matsumura, Hiroshi Nakase, Isao Kosugi, Yusuke Honzawa, Takuya Yoshino, Minoru Matsuura, Hideya Kawasaki, Yoshifumi Arai, Toshihide Iwashita, Takashi Nagasawa, Tsutomu Chiba

Inflammatory bowel diseases　Vol. 19　No. 9　p. 1951-63　2013/08　Research paper (scientific journal)

XRhythmic modulation of the hematopoietic niche through neutrophil clearance

María Casanova-Acebes, Christophe Pitaval, Linnea A. Weiss, César Nombela-Arrieta, Raphaël Chèvre, Noelia A-González, Yuya Kunisaki, Dachuan Zhang, Nico Van Rooijen, Leslie E. Silberstein, Christian Weber, Takashi Nagasawa, Paul S. Frenette, Antonio Castrillo, Andrés Hidalgo

Cell　Vol. 153　No. 5　p. X1025-1035　2013/05/23　Research paper (scientific journal)

Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture

Reiko Nakagawa, Atsushi Togawa, Takashi Nagasawa, Shin-Ichi Nishikawa

Journal of Immunology　Vol. 190　No. 7　p. 3309-3318　2013/04/01　Research paper (scientific journal)

CXCL12 in early mesenchymal progenitors is. required for haematopoietic stem-cell maintenance

Adam Greenbaum, Yen-Michael S. Hsu, Ryan B. Day, Laura G. Schuettpelz, Matthew J. Christopher, Joshua N. Borgerding, Takashi Nagasawa, Daniel C. Link

Nature　Vol. 495　No. 7440　p. 227-230　2013/03　Research paper (scientific journal)

Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin

Wenling Li, Hiroshi Kohara, Yutaka Uchida, Jennifer M. James, Kosha Soneji, Darran G. Cronshaw, Yong-Rui Zou, Takashi Nagasawa, Yoh-suke Mukouyama

Developmental Cell　Vol. 24　No. 4　p. 359-371　2013/02/25　Research paper (scientific journal)

A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure

Anna Aronovich, Yaniv Nur, Elias Shezen, Chava Rosen, Yael Zlotnikov Klionsky, Irit Milman, Liran Yarimi, David Hagin, Gidi Rechavi, Uriel Martinowitz, Takashi Nagasawa, Paul S. Frenette, Dalit Tchorsh-Yutsis, Yair Reisner

Blood　Vol. 122　No. 15　p. 2562-2571　2013　Research paper (scientific journal)

Spi-B is critical for plasmacytoid dendritic cell function and development

Izumi Sasaki, Katsuaki Hoshino, Takahiro Sugiyama, Chihiro Yamazaki, Takahiro Yano, Akihiko Iizuka, Hiroaki Hemmi, Takashi Tanaka, Masuyoshi Saito, Masanaka Sugiyama, Yuri Fukuda, Tomokazu Ohta, Katsuaki Sato, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Noriko Toyama-Sorimachi, Hiroshi Kohara, Takashi Nagasawa, Tsuneyasu Kaisho

Blood　Vol. 120　No. 24　p. 4733-4743　2012/12　Research paper (scientific journal)

Increased Susceptibility to Severe Chronic Liver Damage in CXCR4 Conditional Knock-Out Mice

Atsunori Tsuchiya, Michitaka Imai, Hiroteru Kamimura, Masaaki Takamura, Satoshi Yamagiwa, Tatsuki Sugiyama, Minoru Nomoto, Toshio Heike, Takashi Nagasawa, Tatsutoshi Nakahata, Yutaka Aoyagi

DIGESTIVE DISEASES AND SCIENCES　Vol. 57　No. 11　p. 2892-2900　2012/11　Research paper (scientific journal)

Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system

Chihiro Nishiyama, Toshihiro Uesaka, Takayuki Manabe, Yohei Yonekura, Takashi Nagasawa, Donald F. Newgreen, Heather M. Young, Hideki Enomoto

NATURE NEUROSCIENCE　Vol. 15　No. 9　p. 1211-U64　2012/09　Research paper (scientific journal)

The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal

Takao Sudo, Takafumi Yokota, Kenji Oritani, Yusuke Satoh, Tatsuki Sugiyama, Tatsuro Ishida, Hirohiko Shibayama, Sachiko Ezoe, Natsuko Fujita, Hirokazu Tanaka, Tetsuo Maeda, Takashi Nagasawa, Yuzuru Kanakura

Journal of Immunology　Vol. 189　No. 1　p. 200-210　2012/07/01　Research paper (scientific journal)

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration

Ayako Nakamura-Ishizu, Yuji Okuno, Yoshiki Omatsu, Keisuke Okabe, Junko Morimoto, Toshimitsu Uede, Takashi Nagasawa, Toshio Suda, Yoshiaki Kubota

BLOOD　Vol. 119　No. 23　p. 5429-5437　2012/06　Research paper (scientific journal)

ニッシェによる組織幹細胞の維持

長澤丘司, 尾松芳樹, 杉山立樹

実験医学Vol. 30 No 10（増刊）,21－28（2012）　2012

造血幹細胞のニッシェと造血調節

長澤丘司, 尾松芳樹, 杉山立樹

Anual Review 2012 血液 高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編 中外医学社1－8（2012）　2012

Bone marrow niches for hematopoietic stem cells and immune cells

Tatsuki Sugiyama, Takashi Nagasawa

Inflammation and Allergy - Drug Targets　Vol. 11　No. 3　p. 201-206　2012　Research paper (scientific journal)

Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells

Takashi Nagasawa, Yoshiki Omatsu, Tatsuki Sugiyama

Trends in Immunology　Vol. 32　No. 7　p. 315-320　2011/07

Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero

Yoshiaki Kubota, Keiyo Takubo, Masanori Hirashima, Narihito Nagoshi, Kazuo Kishi, Yuji Okuno, Ayako Nakamura-Ishizu, Keigo Sano, Masato Murakami, Masatsugu Ema, Yoshiki Omatsu, Satoru Takahashi, Takashi Nagasawa, Masabumi Shibuya, Hideyuki Okano, Toshio Suda

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 208　No. 5　p. 949-960　2011/05　Research paper (scientific journal)

Emergency Evacuation! Hematopoietic Niches Induce Cell Exit in Infection

Tatsuki Sugiyama, Takashi Nagasawa

Immunity　Vol. 34　No. 4　p. 463-465　2011/04

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

Yu Lei, Adiratna Mat Ripen, Naozumi Ishimaru, Izumi Ohigashi, Takashi Nagasawa, Lukas T. Jeker, Michael R. Bösl, Georg A. Holländer, Yoshio Hayashi, Rene De Waal Malefyt, Takeshi Nitta, Yousuke Takahama

Journal of Experimental Medicine　Vol. 208　No. 2　p. 383-394　2011/02/14　Research paper (scientific journal)

CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice

Mamiko Noda, Yoshiki Omatsu, Tatsuki Sugiyama, Shinya Oishi, Nobutaka Fujii, Takashi Nagasawa

Blood　Vol. 117　No. 2　p. 451-458　2011/01　Research paper (scientific journal)

CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin-, and neuropeptide y-expressing gabaergic interneurons

Daisuke H. Tanaka, Sakae Mikami, Takashi Nagasawa, Jun-Ichi Miyazaki, Kazunori Nakajima, Fujio Murakami

Cerebral Cortex　Vol. 20　No. 12　p. 2810-2817　2010/12　Research paper (scientific journal)

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4

Fumiyuki Sanematsu, Masanori Hirashima, Melanie Laurin, Ryosuke Takii, Akihiko Nishikimi, Keiko Kitajima, Guo Ding, Mamiko Noda, Yuzo Murata, Yoshihiko Tanaka, Sadahiko Masuko, Toshio Suda, Chikara Meno, Jean-Francois Cote, Takashi Nagasawa, Yoshinori Fukui

CIRCULATION RESEARCH　Vol. 107　No. 9　p. 1102-1105　2010/10　Research paper (scientific journal)

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

Yoshiki Omatsu, Tatsuki Sugiyama, Hiroshi Kohara, Gen Kondoh, Nobutaka Fujii, Kenji Kohno, Takashi Nagasawa

Immunity　Vol. 33　No. 3　p. 387-399　2010/09　Research paper (scientific journal)

Bone marrow graft-versus-host disease: Early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation

Yusuke Shono, Satoshi Ueha, Yong Wang, Jun Abe, Makoto Kurachi, Yoshihiro Matsuno, Tatsuki Sugiyama, Takashi Nagasawa, Masahiro Imamura, Kouji Matsushima

Blood　Vol. 115　No. 26　p. 5401-5411　2010/07/01　Research paper (scientific journal)

幹細胞の維持と血管性ニッチ (特集 血管新生を制御する--いかに血管を作り,そして壊せるか)

長澤 丘司, 尾松 芳樹, 杉山 立樹

細胞工学　Vol. 29　No. 11　p. 1082-1086　2010

Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4

Michelle L. Janas, Gabriele Varano, Kristjan Gudmundsson, Mamiko Noda, Takashi Nagasawa, Martin Turner

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 207　No. 1　p. 247-261　2010/01　Research paper (scientific journal)

The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature

Yoshitsugu Takabatake, Tatsuki Sugiyama, Hiroshi Kohara, Taiji Matsusaka, Hidetake Kurihara, Pandelakis A. Koni, Yasuyuki Nagasawa, Takayuki Hamano, Isao Matsui, Noritaka Kawada, Enyu Imai, Takashi Nagasawa, Hiromi Rakugi, Yoshitaka Isaka

Journal of the American Society of Nephrology　Vol. 20　No. 8　p. 1714-1723　2009/08　Research paper (scientific journal)

SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation

Yan Zhu, Tomoto Matsumoto, Sakae Mikami, Takashi Nagasawa, Fujio Murakami

Development　Vol. 136　No. 11　p. 1919-1928　2009/06/01　Research paper (scientific journal)

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

Toshiyuki Kitaori, Hiromu Ito, Edward M. Schwarz, Ryosuke Tsutsumi, Hiroyuki Yoshitomi, Shinya Oishi, Masakazu Nakano, Nobutaka Fujii, Takashi Nagasawa, Takashi Nakamura

Arthritis and Rheumatism　Vol. 60　No. 3　p. 813-823　2009/03　Research paper (scientific journal)

Random walk behavior of migrating cortical interneurons in the marginal zone: Time-lapse analysis in flat-mount cortex

Daisuke H. Tanaka, Mitsutoshi Yanagida, Yan Zhu, Sakae Mikami, Takashi Nagasawa, Jun-Ichi Miyazaki, Yuchio Yanagawa, Kunihiko Obata, Fujio Murakami

Journal of Neuroscience　Vol. 29　No. 5　p. 1300-1311　2009/02/04　Research paper (scientific journal)

Mechanism of primitive duct formation in the pancreas and submandibular glands: A role for SDF-1

Anne-Christine Hick, Jonathan M Van Eyll, Sabine Cordi, Céline Forez, Lara Passante, Hiroshi Kohara, Takashi Nagasawa, Pierre Vanderhaeghen, Pierre J Courtoy, Guy G Rousseau, Frédéric P Lemaigre, Christophe E Pierreux

BMC Developmental Biology　Vol. 9　No. 1　2009　Research paper (scientific journal)

Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis.

Sakae Mikami, Hiroshi Nakase, Shuji Yamamoto, Yasuhiro Takeda, Takuya Yoshino, Katushiro Kasahara, Satoru Ueno, Norimitsu Uza, Shinya Oishi, Nobutaka Fujii, Takashi Nagasawa, Tsutomu Chiba

The Journal of pharmacology and experimental therapeutics　Vol. 327　No. 2　p. 383-92　2008/11　Research paper (scientific journal)

New niches for B cells

Takashi Nagasawa

Nature Immunology　Vol. 9　No. 4　p. 345-346　2008/04

Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling

Hiroshi Kohara, Yoshiki Omatsu, Tatsuki Sugiyama, Marniko Noda, Nobutaka Fujii, Takashi Nagasawa

Blood　Vol. 110　No. 13　p. 4153-4160　2007/12　Research paper (scientific journal)

The chemokine CXCL12 and regulation of HSC and B lymphocyte development in the bone marrow niche

Takashi Nagasawa

Advances in Experimental Medicine and Biology　Vol. 602　p. 69-75　2007　Research paper (international conference proceedings)

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

Tatsuki Sugiyama, Hiroshi Kohara, Mamiko Noda, Takashi Nagasawa

Immunity　Vol. 25　No. 6　p. 977-988　2006/12　Research paper (scientific journal)

Microenvironmental niches in the bone marrow required for B-cell development

T Nagasawa

Nature Reviews Immunology　Vol. 6　No. 2　p. 107-116　2006/02　Research paper (scientific journal)

A Cxcl12-Cxcr4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons

Lieberam, I, D Agalliu, T Nagasawa, J Ericson, TM Jessell

NEURON　Vol. 47　No. 5　p. 667-679　2005/09　Research paper (scientific journal)

The role of CXCL12 in the organ-specific process of artery formation

T Ara, K Tokoyoda, R Okamoto, PA Koni, T Nagasawa

Blood　Vol. 105　No. 8　p. 3155-3161　2005/04　Research paper (scientific journal)

Cellular niches controlling B lymphocyte behavior within bone marrow during development

K Tokoyoda, T Egawa, T Sugiyama, BI Choi, T Nagasawa

Immunity　Vol. 20　No. 6　p. 707-718　2004/06　Research paper (scientific journal)

Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny

T Ara, K Tokoyoda, T Sugiyama, T Egawa, K Kawabata, T Nagasawa

Immunity　Vol. 19　No. 2　p. 257-267　2003/08　Research paper (scientific journal)

CXCR4 regulates interneuron migration in the developing neocortex

RK Stumm, C Zhou, T Ara, F Lazarini, M Dubois-Dalcq, T Nagasawa, Hollt, V, S Schulz

JOURNAL OF NEUROSCIENCE　Vol. 23　No. 12　p. 5123-5130　2003/06　Research paper (scientific journal)

A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo.

Toshiaki Ara, Manami Itoi, Kenji Kawabata, Takeshi Egawa, Koji Tokoyoda, Tatsuki Sugiyama, Nobutaka Fujii, Takashi Amagai, Takashi Nagasawa

Journal of Immunology (Baltimore, Md. : 1950)　Vol. 170　No. 9　p. 4649-55　2003/05/01

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons

Y Zhu, T Yu, XC Zhang, T Nagasawa, JY Wu, Y Rao

NATURE NEUROSCIENCE　Vol. 5　No. 8　p. 719-720　2002/08　Research paper (scientific journal)

Paranodal junction formation and spermatogenesis require sulfoglycolipids

K Honke, Y Hirahara, J Dupree, K Suzuki, B Popko, K Fukushima, J Fukushima, T Nagasawa, N Yoshida, Y Wada, N Taniguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 99　No. 7　p. 4227-4232　2002/04　Research paper (scientific journal)

The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor

T Egawa, K Kawabata, H Kawamoto, K Amada, R Okamoto, N Fujii, T Kishimoto, Y Katsura, T Nagasawa

Immunity　Vol. 15　No. 2　p. 323-334　2001/08　Research paper (scientific journal)

Role of chemokine SDF-1/PBSF and its receptor CXCR4 in blood vessel development

Takashi Nagasawa

Annals of the New York Academy of Sciences　Vol. 947　p. 112-116　2001　Research paper (international conference proceedings)

A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis

T Nagasawa

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 72　No. 4　p. 408-411　2000/12　Research paper (scientific journal)

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution

Kenji Kawabata, Miho Ujikawa, Takeshi Egawa, Hiroshi Kawamoto, Kazunobu Tachibana, Hisashi Iizasa, Yoshimoto Katsura, Tadamitsu Kishimoto, Takashi Nagasawa

Proceedings of the National Academy of Sciences of the United States of America　Vol. 96　No. 10　p. 5663-5667　1999/05/11　Research paper (scientific journal)

A CXC chemokine SDF-1/PBSF: A ligand for a HIV coreceptor, CXCR4

Takashi Nagasawa, Kazunobu Tachibana, Kenji Kawabata

Advances in Immunology　Vol. 71　p. 211-228　1999

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

T. Naka, T. Matsumoto, M. Narazaki, M. Fujimoto, Y. Morita, Y. Ohsawa, H. Saito, T. Nagasawa, Y. Uchiyama, T. Kishimoto

Proceedings of the National Academy of Sciences　Vol. 95　No. 26　p. 15577-15582　1998/12/22　Research paper (scientific journal)

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

Qing Ma, Dan Jones, Paul R. Borghesani, Rosalind A. Segal, Takashi Nagasawa, Tadamitsu Kismimoto, Roderick T. Bronson, Timothy A. Springer

Proceedings of the National Academy of Sciences of the United States of America　Vol. 95　No. 16　p. 9448-9453　1998/08/04　Research paper (scientific journal)

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

K Tachibana, S Hirota, H Iizasa, H Yoshida, K Kawabata, Y Kataoka, Y Kitamura, K Matsushima, N Yoshida, S Nishikawa, T Kishimoto, T Nagasawa

Nature　Vol. 393　No. 6685　p. 591-594　1998/06　Research paper (scientific journal)

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

T Nagasawa, K Tachibana, T Kishimoto

SEMINARS IN IMMUNOLOGY　Vol. 10　No. 3　p. 179-185　1998/06

Large quantity production with extreme convenience of human SDF-1α and SDF-1β by a Sendai virus vector

Chikaya Moriya, Tatsuo Shioda, Kei Tashiro, Takashi Nagasawa, Masaya Ikegawa, Yukano Ohnishi, Atsushi Kato, Huiling Hu, Xiaomi Xin, Mohammad K. Hasan, Midori Maekawa, Yutaka Takebe, Yuko Sakai, Tasuku Honjo, Yoshiyuki Nagai

FEBS Letters　Vol. 425　No. 1　p. 105-111　1998/03/20　Research paper (scientific journal)

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

T Murakami, T Nakajima, N Koyanagi, K Tachibana, N Fujii, H Tamamura, N Yoshida, M Waki, A Matsumoto, O Yoshie, T Kishimoto, N Yamamoto, T Nagasawa

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 186　No. 8　p. 1389-1393　1997/10　Research paper (scientific journal)

CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry

K Tachibana, T Nakajima, A Sato, K Igarashi, H Shida, H Iizasa, N Yoshida, O Yoshie, T Kishimoto, T Nagasawa

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 185　No. 10　p. 1865-1870　1997/05　Research paper (scientific journal)

Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin

Takashi Nagasawa, Toshihiro Nakajima, Kazunobu Tachibana, Hisashi Iizasa, Conrad C. Bleul, Osamu Yoshie, Kouji Matsushima, Nobuaki Yoshida, Timothy A. Springer, Tadamitsu Kishimoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 93　No. 25　p. 14726-14729　1996/12/10　Research paper (scientific journal)

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

T Nagasawa, S Hirota, K Tachibana, N Takakura, S Nishikawa, Y Kitamura, N Yoshida, H Kikutani, T Kishimoto

Nature　Vol. 382　No. 6592　p. 635-638　1996/08　Research paper (scientific journal)

GENERATION AND CHARACTERIZATION OF A MONOCLONAL-ANTIBODY THAT INHIBITS STROMAL CELL-DEPENDENT B-LYMPHOPOIESIS

T NAGASAWA, T KAISHO, T KISHIMOTO, H KIKUTANI

JOURNAL OF IMMUNOLOGY　Vol. 152　No. 6　p. 2788-2797　1994/03　Research paper (scientific journal)

MOLECULAR-CLONING AND STRUCTURE OF A PRE-B-CELL GROWTH-STIMULATING FACTOR

T NAGASAWA, H KIKUTANI, T KISHIMOTO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 91　No. 6　p. 2305-2309　1994/03　Research paper (scientific journal)

A STROMAL CELL-SPECIFIC MONOCLONAL-ANTIBODY AUGMENTS THE STROMAL CELL-DEPENDENT B-LYMPHOPOIESIS

T KAISHO, T NAGASAWA, T KISHIMOTO, H KIKUTANI

JOURNAL OF IMMUNOLOGY　Vol. 148　No. 4　p. 989-995　1992/02　Research paper (scientific journal)