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Akira Shizuo

審良 静男

Immunology Frontier Research Center, Specially Appointed Professor

Education

  • - 1997, Osaka University, Faculty of Medicine, Medical School
  • - 1997, Osaka University, Faculty of Medicine
  • - 1984, Osaka University
  • - 1984, Osaka University, Graduate School, Division of Medicine

Research History

  • 2007 - Present, Osaka University Immunology Frontier Research Center, Center Director
  • 1999 - Present, Research Institute for Microbial Diseases, Osaka University , Professor
  • 1999 - 2007, Osaka University, Research Institute for Microbial Diseases
  • 1996 - 1999, Hyogo College of Medicine
  • 1996 - 1999, Hyogo College of Medicine, Department of Biochemistry, Professor
  • 1996 - 1999, Hyogo College of Medicine, Professor
  • 1987 - 1995, 大阪大学細胞工学センター 助手
  • 1987 - 1995, Osaka University, Institute for Molecular and Cellular Biology, Research
  • 1985 - 1987, 米国カリフォルニア大学バークレー校ポスト・ドクトラル・フェロー
  • 1985 - 1987, California University, Berkely, Research Fellow
  • 1984 - 1985, 日本学術振興会 奨励研究員
  • 1984 - 1985, Fellowship of Japan Society for Promotion of Science
  • 2007 - , - 大阪大学免疫学フロンティア研究センター 拠点長
  • 1995 - , 大阪大学細胞生体工学センター 助教授
  • 1995 - , Osaka University, Institute for Molecular and Cellular Biology, Associate Professor
  • - , Osaka University, Research Institute for Microbial Diseases
  • - , Associate

Research Areas

  • Life sciences, Immunology
  • Life sciences, Molecular biology

Professional Memberships

  • 米国免疫学会(American Association of Immunologists)
  • 日本分子生物学会
  • 日本免疫学会

Papers

  • Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages, Kenta Maruyama,Hiroyasu Kidoya,Naoki Takemura,Erika Sugisawa,Osamu Takeuchi,Takeshi Kondo,Mohammed Mansour Abbas Eid,Hiroki Tanaka,Mikaël M. Martino,Nobuyuki Takakura,Yasunori Takayama,Shizuo Akira,Alexis Vandenbon,Yutaro Kumagai, Cell Reports, Elsevier BV, Vol. 32, No. 2, p. 107906-107906, 2020/07
  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis., Kiyoharu Fukushima,Takashi Satoh,Fuminori Sugihara,Yuki Sato,Toru Okamoto,Yuichi Mitsui,Sachiyo Yoshio,Songling Li,Satoshi Nojima,Daisuke Motooka,Shota Nakamura,Hiroshi Kida,Daron M Standley,Eiichi Morii,Tatsuya Kanto,Motoko Yanagita,Yoshiharu Matsuura,Takashi Nagasawa,Atsushi Kumanogoh,Shizuo Akira, Immunity, Vol. 52, No. 3, p. 542-556, 2020/03/17
  • Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling, Ziad Julier,Rezvan Karami,Bhavana Nayer,Yen-Zhen Lu,Anthony J. Park,Kenta Maruyama,Gisela A. Kuhn,Ralph Müller,Shizuo Akira,Mikaël M. Martino, Science Advances, Vol. 6, No. 24, 2020
  • Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure Overloaded Hearts., Omiya S,Omori Y,Taneike M,Murakawa T,Ito J,Tanada Y,Nishida K,Yamaguchi O,Satoh T,Shah AM,Akira S,Otsu K, Circulation., 2020/01
  • Beclin 1 regulates recycling endosome and is required for skin development in mice., Noguchi S,Honda S,Saitoh T,Matsumura H,Nishimura E,Akira S,Shimizu S, Commun Biol., Vol. 1, No. 37, 2020/01
  • Regulation of immune responses by endoribonuclease Regnase-1, Shizuo Akira, 2019/11
  • ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity, Masatoshi Momota,Patrick Lelliott,Atsuko Kubo,Takato Kusakabe,Kouji Kobiyama,Etsushi Kuroda,Yumiko Imai,Shizuo Akira,Cevayir Coban,Ken J Ishii, International Immunology, Oxford University Press (OUP), 2019/10/20
  • Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses, 審良 静男, 2019/10
  • Endoribonuclease Regnase-1 controls inflammation and immune responses, 審良 静男, 2019/10
  • B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant., Lee MSJ,Natsume-Kitatani Y,Temizoz B,Fujita Y,Konishi A,Matsuda K,Igari Y,Tsukui T,Kobiyama K,Kuroda E,Onishi M,Marichal T,Ise W,Inoue T,Kurosaki T,Mizuguchi K,Akira S,Ishii KJ,Coban C, European journal of immunology, Vol. 49, No. 9, p. 1433-1440, 2019/09
  • 免疫・炎症応答に関わるリボヌクレアーゼReganase-1, 審良 静男, 2019/08
  • 免疫・炎症応答に関わるリボヌクレアーゼReganase-1, 審良 静男, 2019/07
  • Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses, 審良 静男, 2019/06
  • The role of endoribonulease Regnase-1 in inflammation and immune responses, 審良 静男, 2019/06
  • Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death., Sanjo H,Nakayama J,Yoshizawa T,Fehling HJ,Akira S,Taki S, J Immunol., 2019/06
  • Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice., Kitazume-Taneike R,Taneike M,Omiya S,Misaka T,Nishida K,Yamaguchi O,Akira S,Shattock MJ,Sakata Y,Otsu K, Biochem Biophys Res Commun., 2019/05
  • Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response., Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S, J Exp Med., 2019/05
  • Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity., DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ, 2019/04
  • Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis., Hiroyasu Kidoya,Fumitaka Muramatsu,Teppei Shimamura,Weizhen Jia,Takashi Satoh,Yumiko Hayashi,Hisamichi Naito,Yuya Kunisaki,Fumio Arai,Masahide Seki,Yutaka Suzuki,Tsuyoshi Osawa,Shizuo Akira,Nobuyuki Takakura, Nature communications, Vol. 10, No. 1, p. 1072-1072, 2019/03/06
  • Innate immunity in allergy., Maeda K,Caldez MJ,Akira S, Allergy, 2019/03
  • RNA結合蛋白と炎症, 審良 静男, 2019/03
  • Regnase-1:炎症と免疫応答に重要な核酸分解酵素, 審良 静男, 2019/03
  • The control of inflammatory and immune responses by the endoribonuclease Regnase-1, Shizuo Akira, 2019/03
  • Role of Akirin1 in the regulation of skeletal muscle fiber-type switch., Rao VV,Sangiah U,Mary KA,Akira S,Mohanty A, J Cell Biochem., 2019/02
  • The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study., Müller CP,Chu C,Qin L,Liu C,Xu B,Gao H,Ruggeri B,Hieber S,Schneider J,Jia T,Tay N,Akira S,Satoh T,Banaschewski T,Bokde ALW,Bromberg U,Büchel C,Quinlan EB,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Martinot MP,Artiges E,Lemaitre H,Nees F,Papadopoulos Orfanos D,Paus T,Poustka L,Millenet S,Fröhner JH,Smolka MN,Walter H,Whelan R,Bakalkin G,Liu Y,Desrivières S,Elliott P,Eulenburg V,Levy D,Crews F,Schumann G, Cereb Cortex., 2019/02
  • Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function., Takayuki Imanishi,Midori Unno,Wakana Kobayashi,Natsumi Yoneda,Satoshi Matsuda,Kazutaka Ikeda,Takayuki Hoshii,Atsushi Hirao,Kensuke Miyake,Glen N Barber,Makoto Arita,Ken J Ishii,Shizuo Akira,Takashi Saito, Life science alliance, Vol. 2, No. 1, 2019/02
  • Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice., Brenner D,Sieverding K,Bruno C,Lüningschrör P,Buck E,Mungwa S,Fischer L,Brockmann SJ,Ulmer J,Bliederhäuser C,Philibert CE,Satoh T,Akira S,Boillée S,Mayer B,Sendtner M,Ludolph AC,Danzer KM,Lobsiger CS,Freischmidt A,Weishaupt JH, J Exp Med., Vol. 216, No. 2, p. 267-278, 2019/02
  • Towards understanding the mechanism of lung fibrosis, Shizuo Akira, 2019/02
  • RNA binding protein RBM7 and fibrosis, Shizuo Akira, 2019/02
  • Beclin 1 regulates recycling endosome and is required for skin development in mice., Noguchi S,Honda S,Saitoh T,Matsumura H,Nishimura E,Akira S,Shimizu S, Commun Biol., Vol. 2, 2019/01
  • TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity., Naito H,Iba T,Wakabayashi T,Tai-Nagara I,Suehiro JI,Jia W,Eino D,Sakimoto S,Muramatsu F,Kidoya H,Sakurai H,Satoh T,Akira S,Kubota Y,Takakura N, Dev Cell., Vol. 48, No. 2, p. 151-166, 2019/01
  • USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation., Kusakabe S,Suzuki T,Sugiyama Y,Haga S,Horike K,Tokunaga M,Hirano J,He Z,Chen DV,Ishiga H,Komoda Y,Ono C,Fukuhara T,Yamamoto M,Ikawa M,Satoh T,Akira S,Tanaka T,Moriishi K,Fukai M,Taketomi A,Yoshio S,Kanto T,Suzuki T,Okamoto T,Matsuura Y, J Virol., 2019/01
  • Understanding the molecular mechanism of lung fibrosis, Shizuo Akira, 2019/01
  • Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease., Fang C,Cai X,Hayashi S,Hao S,Sakiyama H,Wang X,Yang Q,Akira S,Nishiguchi S,Fujiwara N,Tsutsui H,Sheng J, Biochim Biophys Acta Mol Cell Biol Lipids., Vol. 1864, No. 3, p. 271-280, 2018/12
  • Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease., Ikeda-Matsuo Y,Miyata H,Mizoguchi T,Ohama E,Naito Y,Uematsu S,Akira S,Sasaki Y,Tanabe M, Neurobiol Dis., Vol. 124, p. 81-92, 2018/11
  • Understanding the molecular mechanism of lung fibrosis, Shizuo Akira, 2018/11
  • Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism., Yasuharu Nagahama,Mayuko Shimoda,Guoliang Mao,Shailendra Kumar Singh,Yuuki Kozakai,Xin Sun,Daisuke Motooka,Shota Nakamura,Hiroki Tanaka,Takashi Satoh,Kazuhiko Maeda,Shizuo Akira, Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 43, p. 11036-11041, 2018/10/23
  • Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin., Flores-Langarica A,Cook C,Müller Luda K,Persson EK,Marshall JL,Beristain-Covarrubias N,Yam-Puc JC,Dahlgren M,Persson JJ,Uematsu S,Akira S,Henderson IR,Lindbom BJ,Agace W,Cunningham AF, Front Immunol., Vol. 9, 2018/10
  • Infection with flaviviruses requires BCLXL for cell survival., Tatsuya Suzuki,Toru Okamoto,Hiroshi Katoh,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Yuka Miyata,Takasuke Fukuhara,Masahito Ikawa,Takashi Satoh,Sachiyo Yoshio,Ryosuke Suzuki,Masayuki Saijo,David C S Huang,Tatsuya Kanto,Shizuo Akira,Yoshiharu Matsuura, PLoS pathogens, Vol. 14, No. 9, 2018/09
  • The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception., Maruyama K,Takayama Y,Sugisawa E,Yamanoi Y,Yokawa T,Kondo T,Ishibashi KI,Sahoo BR,Takemura N,Mori Y,Kanemaru H,Kumagai Y,Martino MM,Yoshioka Y,Nishijo H,Tanaka H,Sasaki A,Ohno N,Iwakura Y,Moriyama Y,Nomura M,Akira S,Tominaga M, iScience., 2018/08
  • Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice, Nobuyuki Nishizawa,Yoshiya Ito,Koji Eshima,Hirotoki Ohkubo,Ken Kojo,Tomoyoshi Inoue,Joan Raouf,Per-Johan Jakobsson,Satoshi Uematsu,Shizuo Akira,Shuh Narumiya,Masahiko Watanabe,Masataka Majima, Journal of Hepatology, Elsevier B.V., Vol. 69, No. 1, p. 110-120, 2018/07/01
  • Hu antigen r regulates antiviral innate immune responses through the stabilization of mRNA for polo-like kinase 2, Takuya Sueyoshi,Takumi Kawasaki,Yuichi Kitai,Daisuke Ori,Shizuo Akira,Taro Kawai, Journal of Immunology, American Association of Immunologists, Vol. 200, No. 11, p. 3814-3824, 2018/06/01
  • Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation, Mikiro Takaishi,Takashi Satoh,Shizuo Akira,Shigetoshi Sano, Journal of Investigative Dermatology, Elsevier B.V., Vol. 138, No. 6, p. 1439-1442, 2018/06/01
  • BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation, Hisashi Kanemaru,Fumihiro Yamane,Hiroki Tanaka,Kazuhiko Maeda,Takashi Satoh,Shizuo Akira, International Immunology, Oxford University Press, Vol. 30, No. 6, p. 255-265, 2018/05/24
  • Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis, Monika Bambouskova,Laurent Gorvel,Vicky Lampropoulou,Alexey Sergushichev,Ekaterina Loginicheva,Kendall Johnson,Daniel Korenfeld,Mary Elizabeth Mathyer,Hyeryun Kim,Li-Hao Huang,Dustin Duncan,Howard Bregman,Abdurrahman Keskin,Andrea Santeford,Rajendra S. Apte,Raghav Sehgal,Britney Johnson,Gaya K. Amarasinghe,Miguel P. Soares,Takashi Satoh,Shizuo Akira,Tsonwin Hai,Cristina De Guzman Strong,Karine Auclair,Thomas P. Roddy,Scott A. Biller,Marko Jovanovic,Eynav Klechevsky,Kelly M. Stewart,Gwendalyn J. Randolph,Maxim N. Artyomov, Nature, Nature Publishing Group, Vol. 556, No. 7702, p. 501-504, 2018/04/26
  • Noninvasive detection of macrophage activation with single-cell resolution through machine learning, Nicolas Pavillon,Alison J. Hobro,Shizuo Akira,Nicholas I. Smith, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 115, No. 12, p. E2676-E2685, 2018/03/20
  • Noninvasive detection of macrophage activation with single-cell resolution through machine learning., Pavillon N,Hobro AJ,Akira S,Smith NI, Proc Natl Acad Sci U S A., 2018/03
  • Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis., Nakagawa K,Matsuki T,Zhao L,Kuniyoshi K,Tanaka H,Ebina I,Yoshida KJ,Nabeshima H,Fukushima K,Kanemaru H,Yamane F,Kawasaki T,Machida T,Naito H,Takakura N,Satoh T,Akira S, Int Immunol., 2018/03
  • BATF2 activates DUSP2 gene expression and upregulates NF-κB activity via phospho-STAT3 dephosphorylation., Kanemaru H,Yamane F,Tanaka H,Maeda K,Satoh T,Akira S, Int Immunol., Vol. 200, No. 8, p. 2987-2999, 2018/03
  • 肺線維化と新規マクロファージサブセット, Shizuo Akira, 2018/03
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2018/03
  • Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner., Katayama Y,Tachibana M,Kurisu N,Oya Y,Terasawa Y,Goda H,Kobiyama K,Ishii KJ,Akira S,Mizuguchi H,Sakurai F, 2018/03
  • Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes., Komine O,Yamashita H,Fujimori-Tonou N,Koike M,Jin S,Moriwaki Y,Endo F,Watanabe S,Uematsu S,Akira S,Uchiyama Y,Takahashi R,Misawa H,Yamanaka K, Cell Death Differ., 2018/03
  • Eosinophil depletion suppresses radiation-induced small intestinal fibrosis., Naoki Takemura,Yosuke Kurashima,Yuki Mori,Kazuki Okada,Takayuki Ogino,Hideki Osawa,Hirosih Matsuno,Lamichhane Aayam,Satoshi Kaneto,Eun Jeong Park,Shintaro Sato,Kouta Matsunaga,Yusuke Tamura,Yasuo Ouchi,Yutaro Kumagai,Daichi Kobayashi,Yutaka Suzuki,Yoshichika Yoshioka,Junichi Nishimura,Masaki Mori,Ken J Ishii,Mark E Rothenberg,Hiroshi Kiyono,Shizuo Akira,Satoshi Uematsu, Science translational medicine, Vol. 10, No. 429, 2018/02/21
  • Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice., Nishizawa N,Ito Y,Eshima K,Ohkubo H,Kojo K,Inoue T,Raouf J,Jakobsson PJ,Uematsu S,Akira S,Narumiya S,Watanabe M,Majima M, J Hepatol., 2018/02
  • Eosinophil depletion suppresses radiation-induced small intestinal fibrosis., Takemura N,Kurashima Y,Mori Y,Okada K,Ogino T,Osawa H,Matsuno H,Aayam L,Kaneto S,Park EJ,Sato S,Matsunaga K,Tamura Y,Ouchi Y,Kumagai Y,Kobayashi D,Suzuki Y,Yoshioka Y,Nishimura J,Mori M,Ishii KJ,Rothenberg ME,Kiyono H,Akira S,Uematsu S, Sci Transl Med., 2018/02
  • マクロファージ・単球サブセットと病態, 審良 静男, 2018/02
  • マクロファージ・単球サブセットと病態, Shizuo Akira, 2018/02
  • Batf2 のIL-12p40 発現促進による抗腫瘍効果について, Hisashi Kanemaru, 2018/02
  • Autophagy limits activation of the inflammasomes., Takahama M,Akira S,Saitoh T, Immunol Rev., Vol. 281, No. 1, p. 62-73, 2018/01
  • 各種病態にかかわるマクロファージ・単球サブセット, Shizuo Akira, 2017/12
  • Basic leucine zipper transcription factor ATF-like 2 exhibits an anti-tumor effect through upregulation of IL-12 p40 expression, Hisashi Kanemaru,Fumihiro Yamane,Kiyoharu Fukushima,Takanori Matsuki,Takahiro Kawasaki,Isao Ebina,Kanako Kuniyoshi,Hiroki Tanaka,Kenta Maruyama,Kazuhiko Maeda,Takashi Satoh,Shizuo Akira, 2017/12
  • Screening of causative genes for fibrosis development in mice, Kiyoharu Fukushima,Takashi Satoh,Atsushi Kumanogoh,Shizuo Akira, 2017/12
  • Role of macrophages in the development of fibrosis, Shizuo Akira, 2017/12
  • The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways (vol 27, pg 3378, 2017), Alessandro Sessa,Ernesto Ciabatti,Daniela Drechsel,Luca Massimino,Gaia Colasante,Serena Giannelli,Takashi Satoh,Shizuo Akira,Francois Guillemot,Vania Broccoli, CEREBRAL CORTEX, OXFORD UNIV PRESS INC, Vol. 27, No. 12, p. 5715-5715, 2017/12
  • T helper 17 Promotes induction of antigen-specific gut-Mucosal cytotoxic T lymphocytes following adenovirus Vector Vaccination, Masahisa Hemmi,Masashi Tachibana,Natsuki Fujimoto,Masaki Shoji,Fuminori Sakurai,Kouji Kobiyama,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA SA, Vol. 8, 2017/11
  • Identification of a Monocyte Subset Responsible for Lung Fibrosis, Shizuo Akira, 2017/11
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2017/11
  • Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis, Carole Henique,Guillaume Bollee,Xavier Loyer,Florian Grahammer,Neeraj Dhaun,Marine Camus,Julien Vernerey,Lea Guyonnet,Francois Gaillard,Helene Lazareth,Charlotte Meyer,Imane Bensaada,Luc Legres,Takashi Satoh,Shizuo Akira,Patrick Bruneval,Stefanie Dimmeler,Alain Tedgui,Alexandre Karras,Eric Thervet,Dominique Nochy,Tobias B. Huber,Laurent Mesnard,Olivia Lenoir,Pierre-Louis Tharaux, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 8, No. 1, 2017/11
  • Macrophage/monocyte subsets involved in a variety of diseases, Shizuo Akira, 2017/10
  • 各種病態に関わるマクロファージサブセット, Shizuo Akira, 2017/10
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2017/10
  • Regnase-1 is a key endoribonuclease that controls the inflammatory and immune responses, Shizuo Akira, 2017/10
  • The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses, Michihiro Takahama,Mitsunori Fukuda,Norihiko Ohbayashi,Tatsuya Kozaki,Takuma Misawa,Toru Okamoto,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh, CELL REPORTS, CELL PRESS, Vol. 20, No. 12, p. 2944-2954, 2017/09
  • Identification of macrophage/monocyte subsets with distinct functions, Shizuo Akira, 2017/09
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2017/09
  • 自然免疫と炎症, Shizuo Akira, 2017/09
  • The antitumor effect of basic leucine zipper transcription factor ATF-like 2 through IL-12 p40 upregulation, Hisashi Kanemaru,Takashi Satoh,Satoshi Fukushima,Hironobu Ihn,Shizuo Akira, 2017/09
  • Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense., Miwa Sasai,Naoya Sakaguchi,Ji Su Ma,Shuhei Nakamura,Tsuyoshi Kawabata,Hironori Bando,Youngae Lee,Tatsuya Saitoh,Shizuo Akira,Akiko Iwasaki,Daron M Standley,Tamotsu Yoshimori,Masahiro Yamamoto, Nature immunology, Vol. 18, No. 8, p. 899-910, 2017/08
  • Netrins as prophylactic targets in skeletal diseases: A double-edged sword?, Kenta Maruyama,Naoki Takemura,Mikaël M Martino,Takeshi Kondo,Shizuo Akira, Pharmacological research, Vol. 122, p. 46-52, 2017/08
  • Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis, Jiefei Geng,Yasushi Ito,Linyu Shi,Palak Amin,Jiachen Chu,Amanda Tomie Ouchida,Adnan Kasim Mookhtiar,Heng Zhao,Daichao Xu,Bing Shan,Ayaz Najafov,Guangping Gao,Shizuo Akira,Junying Yuan, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 8, No. 1, 2017/08
  • 各種病態に関わるマクロファージサブセット, Shizuo Akira, 2017/07
  • 自然免疫の最近の進歩, Shizuo Akira, 2017/07
  • 炎症とマクロファージ・サブセット, Shizuo Akira, 2017/07
  • Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis., Kenta Maruyama,Yasunori Takayama,Takeshi Kondo,Ken-Ichi Ishibashi,Bikash Ranjan Sahoo,Hisashi Kanemaru,Yutaro Kumagai,Mikaël M Martino,Hiroki Tanaka,Naohito Ohno,Yoichiro Iwakura,Naoki Takemura,Makoto Tominaga,Shizuo Akira, Cell reports, Vol. 19, No. 13, p. 2730-2742, 2017/06/27
  • Plasmodium products persist in the bone marrow and promote chronic bone loss., Michelle S J Lee,Kenta Maruyama,Yukiko Fujita,Aki Konishi,Patrick M Lelliott,Sawako Itagaki,Toshihiro Horii,Jing-Wen Lin,Shahid M Khan,Etsushi Kuroda,Shizuo Akira,Ken J Ishii,Cevayir Coban, Science immunology, Vol. 2, No. 12, 2017/06/02
  • An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling, Philipp Mertins,Dariusz Przybylski,Nir Yosef,Jana Qiao,Karl Clauser,Raktima Raychowdhury,Thomas M. Eisenhaure,Tanja Maritzen,Volker Haucke,Takashi Satoh,Shizuo Akira,Steven A. Carr,Aviv Regev,Nir Hacohen,Nicolas Chevrier, CELL REPORTS, CELL PRESS, Vol. 19, No. 13, p. 2853-2866, 2017/06
  • The Control of Inflammatory and immune responses by the endoribonuclease, Shizuo Akira, 2017/06
  • Role of selective regulation of non-coding RNA by mammalian mRNA export complex TREX-2, Mayuko Shimoda,Kazuhiko Maeda,Shailendra Singh,Shizuo Akira,Nobuo Sakaguchi, 2017/06
  • Regnase1によるmRNA制御, Shizuo Akira, 2017/06
  • 線維症における新規のマクロファージサブタイプの同定, 福島 清春,佐藤 荘,熊ノ郷 淳,審良 静男, 2017/06
  • Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice, Takumi Kawasaki,Kosuke Ito,Haruhiko Miyata,Shizuo Akira,Taro Kawai, EMBO JOURNAL, WILEY, Vol. 36, No. 12, p. 1707-1718, 2017/06
  • The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways, Alessandro Sessa,Ernesto Ciabatti,Daniela Drechsel,Luca Massimino,Gaia Colasante,Serena Giannelli,Takashi Satoh,Shizuo Akira,Francois Guillemot,Broccoli Vania, CEREBRAL CORTEX, OXFORD UNIV PRESS INC, Vol. 27, No. 6, p. 3378-3396, 2017/06
  • Towards understanding the mechanism of fibrosis induced by viral infection, Shizuo Akira, 2017/05
  • Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase- mediated antiviral response, Tatsuya Kozaki,Jun Komano,Daiki Kanbayashi,Michihiro Takahama,Takuma Misawa,Takashi Satoh,Osamu Takeuchi,Taro Kawai,Shigeomi Shimizu,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 114, No. 10, p. 2681-2686, 2017/03
  • 自然免疫と炎症, 審良 静男, 2017/03
  • Identification of a Monocyte Subset Responsible for Lung Fibrosis, Shizuo Akira, 2017/03
  • 自然免疫の最近の進歩, 審良 静男, 2017/02
  • G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE(2), Yuko Kawano,Chie Fukui,Masakazu Shinohara,Kanako Wakahashi,Shinichi Ishii,Tomohide Suzuki,Mari Sato,Noboru Asada,Hiroki Kawano,Kentaro Minagawa,Akiko Sada,Tomoyuki Furuyashiki,Satoshi Uematsu,Shizuo Akira,Toshimitsu Uede,Shuh Narumiya,Toshimitsu Matsui,Yoshio Katayama, BLOOD, AMER SOC HEMATOLOGY, Vol. 129, No. 5, p. 587-597, 2017/02
  • DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING- Dependent Pathway and Reinforce Antitumor Immunity, Yuichi Kitai,Takumi Kawasaki,Takuya Sueyoshi,Kouji Kobiyama,Ken J. Ishii,Jian Zou,Shizuo Akira,Tadashi Matsuda,Taro Kawai, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 198, No. 4, p. 1649-1659, 2017/02
  • Identification of an atypical monocyte and committed progenitor involved in fibrosis, Takashi Satoh,Katsuhiro Nakagawa,Fuminori Sugihara,Ryusuke Kuwahara,Motooki Ashihara,Fumihiro Yamane,Yosuke Minowa,Kiyoharu Fukushima,Isao Ebina,Yoshichika Yoshioka,Atsushi Kumanogoh,Shizuo Akira, NATURE, NATURE PUBLISHING GROUP, Vol. 541, No. 7635, p. 96-+, 2017/01
  • Identification of a Monocyte Subset Responsible for Lung Fibrosis, 審良 静男, 2017/01
  • Batf2 has an anti-tumor effect through upregulation of IL-12 p40 in tumor-associated macrophages, Hisashi Kanemaru, 2017/01
  • Functional diversity of macrophage/monocyte subsets revealed by gene targeting, Shizuo Akira, 2017/01
  • Identification of an atypical monocyte and committed progenitor involved in fibrosis, Takashi Satoh,Katsuhiro Nakagawa,Fuminori Sugihara,Ryusuke Kuwahara,Motooki Ashihara,Fumihiro Yamane,Yosuke Minowa,Kiyoharu Fukushima,Isao Ebina,Yoshichika Yoshioka,Atsushi Kumanogoh,Shizuo Akira, NATURE, NATURE PUBLISHING GROUP, Vol. 541, No. 7635, p. 96-+, 2017/01
  • KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference, Gunter Schumann,Chunyu Liu,Paul O'Reilly,He Gao,Parkyong Song,Bing Xu,Barbara Ruggeri,Najaf Amin,Tianye Jia,Sarah Preis,Marcelo Segura Lepe,Shizuo Akira,Caterina Barbieri,Sebastian Baumeister,Stephane Cauchi,Toni-Kim Clarke,Stefan Enroth,Krista Fischer,Jenni Hallfors,Sarah E. Harris,Saskia Hieber,Edith Hofer,Jouke-Jan Hottenga,Asa Johansson,PeterK. Joshi,Niina Kaartinen,Jaana Laitinen,Rozenn Lemaitre,Anu Loukola,Jian'an Luan,Leo-Pekka Lyytikainen,Massimo Mangino,Ani Manichaikul,Hamdi Mbarek,Yuri Milaneschi,Alireza Moayyeri,Kenneth Mukamal,Christopher Nelson,Jennifer Nettleton,Eemil Partinen,Rajesh Rawal,Antonietta Robino,Lynda Rose,Cinzia Sala,Takashi Satoh,Reinhold Schmidt,Katharina Schrautz,Robert Scott,Albert Vernon Smith,John M. Starr,Alexander Teumer,Stella Trompet,Andre G. Uitterlinden,Cristina Venturini,Anne-Claire Vergnaud,Niek Verweij,Veronique Vitart,Dragana Vuckovic,Juho Wedenoja,Loic Yengo,Bing Yu,Weihua Zhang,Jing Hua Zhao,Dorret I. Boomsma,John Chambers,Daniel I. Chasman,Toniolo Daniela,Eco de Geus,Ian Deary,Johan G. Eriksson,Tonu Esko,Volker Eulenburg,Oscar H. Franco,Philippe Froguel,Christian Gieger,Hans J. Grabe,Vilmundur Gudnason,Ulf Gyllensten,Tamara B. Harris,Anna-Liisa Hartikainen,Andrew C. Heath,Lynne Hocking,Albert Hofman,Cornelia Huth,Marjo-Riitta Jarvelin,J. Wouter Jukema,Jaakko Kaprio,Jaspal S. Kooner,Zoltan Kutalik,Jari Lahti,Claudia Langenberg,Terho Lehtimaki,Yongmei Liu,Pamela A. F. Madden,Nicholas Martin,Alanna Morrison,Brenda Penninx,Nicola Pirastu,Bruce Psaty,Olli Raitakari,Paul Ridker,Richard Rose,Jerome I. Rotter,Nilesh J. Samani,Helena Schmidt,Tim D. Spector,David Stott,David Strachan,Ioanna Tzoulaki,Pim van der Harst,Cornelia M. van Duijn,Pedro Marques-Vidal,Peter Vollenweider,Nicholas J. Wareham,John B. Whitfield,James Wilson,Bruce Wolffenbuttel,Georgy Bakalkin,Evangelos Evangelou,Yun Liu,Kenneth M. Rice,Sylvane Desrivieres,Steven A. Kliewer,David J. Mangelsdorf,Christian P. Muller,Daniel Levy,Paul Elliott, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, No. 50, p. 14372-14377, 2016/12
  • Regulation of HIV-1 mRNA export by a host TREX-2 component GANP, Mayuko Shimoda, 2016/12
  • 自然免疫の最近の進歩, 審良 静男, 2016/12
  • マクロファージ・単球サブセットとその役割, 審良 静男, 2016/12
  • Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation, Shigemiki Omiya,Yosuke Omori,Manabu Taneike,Andrea Protti,Osamu Yamaguchi,Shizuo Akira,Ajay M. Shah,Kazuhiko Nishida,Kinya Otsu, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Vol. 311, No. 6, p. H1485-H1497, 2016/12
  • Genome-wide map of RNA degradation kinetics patterns in dendritic cells after LPS stimulation facilitates identification of primary sequence and secondary structure motifs in mRNAs, Yutaro Kumagai,Alexis Vandenbon,Shunsuke Teraguchi,Shizuo Akira,Yutaka Suzuki, BMC GENOMICS, BIOMED CENTRAL LTD, Vol. 17, No. Suppl 13, 2016/12
  • Bone-protective Functions of Netrin 1 Protein., Kenta Maruyama,Takahiko Kawasaki,Masahide Hamaguchi,Motomu Hashimoto,Moritoshi Furu,Hiromu Ito,Takao Fujii,Naoki Takemura,Thangaraj Karuppuchamy,Takeshi Kondo,Takumi Kawasaki,Masahiro Fukasaka,Takuma Misawa,Tatsuya Saitoh,Yutaka Suzuki,Mikaël M Martino,Yutaro Kumagai,Shizuo Akira, The Journal of biological chemistry, Vol. 291, No. 46, p. 23854-23868, 2016/11/11
  • 自然免疫と創薬の未来, 審良 静男, 2016/11
  • 各種病態に関わるマクロファージ・サブセット, 審良 静男, 2016/11
  • Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product, Katsuaki Hoshino,Osamu Takeuchi,Taro Kawai,Hideki Sanjo,Tomohiko Ogawa,Yoshifumi Takeda,Kiyoshi Takeda,Shizuo Akira, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 197, No. 7, p. 3749-3752, 2016/10
  • Innate immunity and Inflammation, Shizuo Akira, 2016/10
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2016/10
  • Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product., Hoshino K,Takeuchi O,Kawai T,Sanjo H,Ogawa T,Takeda Y,Takeda K,Akira S, J Immunol., Vol. 197, No. 7, p. 2563-2566, 2016/10
  • TLR7 Structure: Cut in Z-Loop, Kazuhiko Maeda,Shizuo Akira, IMMUNITY, CELL PRESS, Vol. 45, No. 4, p. 705-707, 2016/10
  • Functions of macrophage/monocyte subsets revealed by gene targeting, Shizuo Akira, 2016/09
  • Innate Molecular Identification of a novel monocyte subset involved in lung fibrosis, S. Akira, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Vol. 46, p. 500-501, 2016/08
  • 免疫・炎症に関わるマクロファージ・単球サブセット, 審良 静男, 2016/07
  • マクロファージ・単球サブセットの同定と機能的役割, 審良 静男, 2016/07
  • Regulation of inflammasomes by autophagy, Tatsuya Saitoh,Shizuo Akira, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 138, No. 1, p. 28-36, 2016/07
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2016/06
  • Anti-viral responses mediated by ZAP-like receptors, Tatsuta Saitoh,Tatsuya Kozaki,Shizuo Akira, 2016/06
  • Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency, Asuka Terashima,Kazuo Okamoto,Tomoki Nakashima,Shizuo Akira,Koichi Ikuta,Hiroshi Takayanagi, IMMUNITY, CELL PRESS, Vol. 44, No. 6, p. 1434-1443, 2016/06
  • Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs, Diana Rose E. Ranoa,Akash D. Parekh,Sean P. Pitroda,Xiaona Huang,Thomas Darga,Anthony C. Wong,Lei Huang,Jorge Andrade,Jonathan P. Staley,Takashi Satoh,Shizuo Akira,Ralph R. Weichselbaum,Nikolai N. Khodarev, ONCOTARGET, IMPACT JOURNALS LLC, Vol. 7, No. 18, p. 26496-26515, 2016/05
  • Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia, Ryu Okumura,Takashi Kurakawa,Takashi Nakano,Hisako Kayama,Makoto Kinoshita,Daisuke Motooka,Kazuyoshi Gotoh,Taishi Kimura,Naganori Kamiyama,Takashi Kusu,Yoshiyasu Ueda,Hong Wu,Hideki Iijima,Soumik Barman,Hideki Osawa,Hiroshi Matsuno,Junichi Nishimura,Yusuke Ohba,Shota Nakamura,Tetsuya Iida,Masahiro Yamamoto,Eiji Umemoto,Koichi Sano,Kiyoshi Takeda, Nature, Nature Publishing Group, Vol. 532, No. 7597, p. 117-121, 2016/04/07
  • マクロファージ・単球サブセットとその役割, 審良 静男, 2016/04
  • Functional diversity in macrophage/monocyte subsets., Shizuo Akira, 2016/04
  • Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Mikael M. Martino,Kenta Maruyama,Gisela A. Kuhn,Takashi Satoh,Osamu Takeuchi,Ralph Mueller,Shizuo Akira, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 7, 2016/03
  • 各種病態に関わるマクロファージ・単球サブセットの同定, 審良 静男, 2016/03
  • 自然免疫と炎症, 審良 静男, 2016/03
  • Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions, Mariko Yokogawa,Takashi Tsushima,Nobuo N. Noda,Hiroyuki Kumeta,Yoshiaki Enokizono,Kazuo Yamashita,Daron M. Standley,Osamu Takeuchi,Shizuo Akira,Fuyuhiko Inagaki, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 6, 2016/03
  • TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector, Sayaka Tsuzuki,Masashi Tachibana,Masahisa Hemmi,Tomoko Yamaguchi,Masaki Shoji,Fuminori Sakurai,Kouji Kobiyama,Kenji Kawabata,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 28, No. 3, p. 105-115, 2016/03
  • Functional diversity in macrophage/monocyte subsets., Shizuo Akira, 2016/02
  • PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Ting-Hin Ho,Chun Kew,Pak-Yin Lui,Chi-Ping Chan,Takashi Satoh,Shizuo Akira,Dong-Yan Jin,Kin-Hang Kok, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 90, No. 3, p. 1557-1568, 2016/02
  • LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation, Morimoto, K.,Baba, Y.,Shinohara, H.,Kang, S.,Nojima, S.,Kimura, T.,Ito, D.,Yoshida, Y.,Maeda, Y.,Sarashina-Kida, H.,Nishide, M.,Hosokawa, T.,Kato, Y.,Hayama, Y.,Kinehara, Y.,Okuno, T.,Takamatsu, H.,Hirano, T.,Shima, Y.,Narazaki, M.,Kurosaki, T.,Toyofuku, T.,Kumanogoh, A., Sci Rep, Vol. 6, p. 25738-25738, 2016
  • Toll-like receptor signaling and its inducible proteins, Takashi Satoh,Shizuo Akira, Microbiology Spectrum, American Society for Microbiology, Vol. 4, No. 6, 2016
  • Impaired autophagy in macrophages promotes inflammatory eye disease, Andrea Santeford,Luke A. Wiley,Sunmin Park,Sonya Bamba,Rei Nakamura,Abdelaziz Gdoura,Thomas A. Ferguson,P. Kumar Rao,Jun-Lin Guan,Tatsuya Saitoh,Shizuo Akira,Ramnik Xavier,Herbert W. Virgin,Rajendra S. Apte, AUTOPHAGY, TAYLOR & FRANCIS INC, Vol. 12, No. 10, p. 1876-1885, 2016
  • Raman spectroscopy as a tool for label-free lymphocyte cell line discrimination, Alison J. Hobro,Yutaro Kumagai,Shizuo Akira,Nicholas I. Smith, ANALYST, ROYAL SOC CHEMISTRY, Vol. 141, No. 12, p. 3756-3764, 2016
  • Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation, Sunmin Park,Michael D. Buck,Chandni Desai,Xin Zhang,Ekaterina Loginicheva,Jennifer Martinez,Michael L. Freeman,Tatsuya Saitoh,Shizuo Akira,Jun-Lin Guan,You-Wen He,Marcia A. Blackman,Scott A. Handley,Beth Levine,Douglas R. Green,Tiffany A. Reese,Maxim N. Artyomov,Herbert W. Virgin, CELL HOST & MICROBE, CELL PRESS, Vol. 19, No. 1, p. 91-101, 2016/01
  • Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages, Pengyan Xia,Shuo Wang,Ying Du,Guanling Huang,Takashi Satoh,Shizuo Akira,Zusen Fan, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 212, No. 13, p. 2305-2321, 2015/12
  • The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication, Harshad Ingle,Sushil Kumar,Ashwin Ashok Raut,Anamika Mishra,Diwakar Dattatraya Kulkarni,Takeshi Kameyama,Akinori Takaoka,Shizuo Akira,Himanshu Kumar, SCIENCE SIGNALING, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 8, No. 406, 2015/12
  • TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair, Yuji Ogura,Sajedah M. Hindi,Shuichi Sato,Guangyan Xiong,Shizuo Akira,Ashok Kumar, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 6, 2015/12
  • Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model, Hiromi Matsuda,Kanako Hosono,Seri Tsuru,Chie Kurashige,Kazuki Sekiguchi,Shizuo Akira,Satoshi Uematsu,Hirotsugu Okamoto,Masataka Majima, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 142, p. 1-7, 2015/12
  • Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis, Masaki Inada,Morichika Takita,Satoshi Yokoyama,Kenta Watanabe,Tsukasa Tominari,Chiho Matsumoto,Michiko Hirata,Yoshiro Maru,Takayuki Maruyama,Yukihiko Sugimoto,Shuh Narumiya,Satoshi Uematsu,Shizuo Akira,Gillian Murphy,Hideaki Nagase,Chisato Miyaura, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 50, p. 29781-29793, 2015/12
  • P62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen, Youngae Lee,Miwa Sasai,Ji Su Ma,Naoya Sakaguchi,Jun Ohshima,Hironori Bando,Tatsuya Saitoh,Shizuo Akira,Masahiro Yamamoto, Cell Reports, Elsevier, Vol. 13, No. 2, p. 223-233, 2015/10/13
  • 免疫反応におけるmRNA制御, 審良 静男, 2015/10
  • Antiviral responses revealed by gene targeting, Shizuo Akira, 2015/10
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2015/09
  • Regnase-1, a ribonuclease essential to the inflammatory and immune responses, Shizuo Akira, 2015/09
  • Role of the Atg9a gene in intrauterine growth and survival of fetal mice, Takashi Kojima,Takahiro Yamada,Rina Akaishi,Itsuko Furuta,Tatsuya Saitoh,Kazuhiko Nakabayashi,Keiichi I. Nakayama,Keiko Nakayama,Shizuo Akira,Hisanori Minakami, REPRODUCTIVE BIOLOGY, INST ANIMAL REPRODUCTION FOOD RESEARCH, Vol. 15, No. 3, p. 131-138, 2015/09
  • Resveratrol inhibits the acetylated alpha-tubulin-mediated assembly of the NLRP3-inflammasome, Takuma Misawa,Tatsuya Saitoh,Tatsuya Kozaki,Sehoon Park,Michihiro Takahama,Shizuo Akira, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 27, No. 9, p. 425-434, 2015/09
  • Emerging molecules in the interface between skeletal system and innate immunity, Kenta Maruyama,Shizuo Akira, PHARMACOLOGICAL RESEARCH, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 99, p. 223-228, 2015/09
  • MTOR complex signaling through the SEMA4A-plexin B2 axis is required for optimal activation and differentiation of CD8<sup>+</sup> T cells, Daisuke Ito,Satoshi Nojima,Masayuki Nishide,Tatsusada Okuno,Hyota Takamatsu,Sujin Kang,Tetsuya Kimura,Yuji Yoshida,Keiko Morimoto,Yohei Maeda,Takashi Hosokawa,Toshihiko Toyofuku,Jun Ohshima,Daisuke Kamimura,Masahiro Yamamoto,Masaaki Murakami,Eiichi Morii,Hiromi Rakugi,Yoshitaka Isaka,Atsushi Kumanogoh, Journal of Immunology, American Association of Immunologists, Vol. 195, No. 3, p. 934-943, 2015/08/01
  • Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production, Adriana Flores-Langarica,Saeeda Bobat,Jennifer L. Marshall,Juan Carlos Yam-Puc,Charlotte N. Cook,Karine Serre,Robert A. Kingsley,Leopoldo Flores-Romo,Satoshi Uematsu,Shizuo Akira,Ian R. Henderson,Kai M. Toellner,Adam F. Cunningham, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Vol. 45, No. 8, p. 2299-2311, 2015/08
  • Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation, Eriko Sumiya,Takako Negishi-Koga,Yusuke Nagai,Ayako Suematsu,Tomomi Suda,Masahiro Shinohara,Kojiro Sato,Hideki Sanjo,Shizuo Akira,Hiroshi Takayanagi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 463, No. 4, p. 1284-1290, 2015/08
  • STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch, Miho Shiratori-Hayashi,Keisuke Koga,Hidetoshi Tozaki-Saitoh,Yuta Kohro,Honami Toyonaga,Chiharu Yamaguchi,Ayumi Hasegawa,Takeshi Nakahara,Junichi Hachisuka,Shizuo Akira,Hideyuki Okano,Masutaka Furue,Kazuhide Inoue,Makoto Tsuda, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 21, No. 8, p. 927-931, 2015/08
  • Role of zinc-finger anti-viral protein in host defense against Sindbis virus, Tatsuya Kozaki,Michihiro Takahama,Takuma Misawa,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 27, No. 7, p. 357-364, 2015/07
  • Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy, Yuya Asahina,Shinobu Komiya,Ami Ohagi,Rina Fujimoto,Hiroko Tamagaki,Katsuhiro Nakagawa,Takashi Sato,Shizuo Akira,Toshifumi Takao,Akira Ishii,Yoshiaki Nakahara,Hironobu Hojo, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, Vol. 54, No. 28, p. 8226-8230, 2015/07
  • Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCR alpha beta(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis, Hideki Sanjo,Shigeo Tokumaru,Shizuo Akira,Shinsuke Taki, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 7, 2015/07
  • Regnase-1, a ribonuclease involved in the inflammatory and immune responses, Shizuo Akira, 2015/07
  • Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications., Yuji Yoshida,Atsushi Ogata,Sujin Kang,Kousuke Ebina,Kenrin Shi,Satoshi Nojima,Tetsuya Kimura,Daisuke Ito,Keiko Morimoto,Masayuki Nishide,Takashi Hosokawa,Toru Hirano,Yoshihito Shima,Masashi Narazaki,Hideki Tsuboi,Yukihiko Saeki,Tetsuya Tomita,Toshio Tanaka,Atsushi Kumanogoh, Arthritis & rheumatology (Hoboken, N.J.), Vol. 67, No. 6, p. 1481-90, 2015/06
  • The role of Regnase-1 in the immune response, Shizuo Akira, 2015/06
  • Functional diversity of macrophage/monocyte subsets, Shizuo Akira, 2015/06
  • Role of interleukin-33 during Schistosoma mansoni infection, Yombo Kalenda,Kyoko Masuda,Eman Sayed,Risa Nakamura,Kentaro Kato,Satoshi Uematsu,Shizuo Akira,Shinjiro Hamano, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 194, 2015/05
  • Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes, Michelle Goritzka,Spyridon Makris,Fahima Kausar,Lydia R. Durant,Catherine Pereira,Yutaro Kumagai,Fiona J. Culley,Matthias Mack,Shizuo Akira,Cecilia Johansson, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 212, No. 5, p. 699-714, 2015/05
  • IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity, S. Kumar,H. Ingle,S. Mishra,R. S. Mahla,A. Kumar,T. Kawai,S. Akira,A. Takaoka,A. A. Raut,H. Kumar, CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, Vol. 6, 2015/05
  • A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway, Masahiro Fukasaka,Daisuke Asari,Eiji Kiyotoh,Arimichi Okazaki,Yasuyuki Gomi,Takeshi Tanimoto,Osamu Takeuchi,Shizuo Akira,Mitsuhiko Hori, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 5, 2015/05
  • Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms, Takashi Mino,Yasuhiro Murakawa,Akira Fukao,Alexis Vandenbon,Hans-Hermann Wessels,Daisuke Ori,Takuya Uehata,Sarang Tartey,Shizuo Akira,Yutaka Suzuki,Carola G. Vinuesa,Uwe Ohler,Daron M. Standley,Markus Landthaler,Toshinobu Fujiwara,Osamu Takeuchi, CELL, CELL PRESS, Vol. 161, No. 5, p. 1058-1073, 2015/05
  • Regnase-1, a ribonuclease involved in the inflammatory and immune responses, Shizuo Akira, 2015/05
  • Regnase-1: a ribonuclease involved in innate and adaptive immunity, Shizuo Akira, 2015/05
  • Glucocorticoid augments lipopolysaccharide-induced activation of the I kappa B zeta-dependent genes encoding the anti-microbial glycoproteins lipocalin 2 and pentraxin 3, Soh Yamazaki,Shizuo Akira,Hideki Sumimoto, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 157, No. 5, p. 399-410, 2015/05
  • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice (vol 161, pg 4652, 1998), K. Takeda,T. Kaisho,N. Yoshida,J. Takeda,T. Kishimoto,S. Akira, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 194, No. 7, p. 3526-3526, 2015/04
  • Toll-like receptors., Takeda K,Akira S, Curr Protoc Immunol, Vol. 109, p. 14.12.1-14.12.10, 2015/04
  • Control of the inflammatory and immune responses by the ribonuclease, Regnase-1, Shizuo Akira, 2015/04
  • 5-Azacytidine-induced Protein 2 (AZI2) Regulates Bone Mass by Fine-tuning Osteoclast Survival, Kenta Maruyama,Masahiro Fukasaka,Satoshi Uematsu,Osamu Takeuchi,Takeshi Kondo,Tatsuya Saitoh,Mikael M. Martino,Shizuo Akira, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 15, p. 9377-9386, 2015/04
  • TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus, Taito Matsuda,Naoya Murao,Yuki Katano,Berry Juliandi,Jun Kohyama,Shizuo Akira,Taro Kawai,Kinichi Nakashima, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 6, 2015/03
  • 自然免疫と炎症, Shizuo Akira, 2015/03
  • 自然免疫の最近の進歩, Shizuo Akira, 2015/03
  • Rapid CD4(+) T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9, Shaikh M. Atif,Seung-Joo Lee,Lin-Xi Li,Satoshi Uematsu,Shizuo Akira,Sara Gorjestani,Xin Lin,Edina Schweighoffer,Victor L. J. Tybulewicz,Stephen J. McSorley, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Vol. 45, No. 2, p. 513-524, 2015/02
  • Regnase-1, a ribonuclease involved in the control of immune responses, Shizuo Akira, 2015/01
  • Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B, Yuichi Kitai,Osamu Takeuchi,Takumi Kawasaki,Daisuke Ori,Takuya Sueyoshi,Motoya Murase,Shizuo Akira,Taro Kawai, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 290, No. 2, p. 1269-1280, 2015/01
  • Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation, Meghana N. Patel,William G. Bernard,Nikolay B. Milev,William P. Cawthorn,Nichola Figg,Dan Hart,Xavier Prieur,Sam Virtue,Krisztina Hegyi,Stephanie Bonnafous,Beatrice Bailly-Maitre,Yajing Chu,Julian L. Griffin,Ziad Mallat,Robert V. Considine,Albert Tran,Philippe Gual,Osamu Takeuchi,Shizuo Akira,Antonio Vidal-Puig,Martin R. Bennett,Jaswinder K. Sethi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 112, No. 2, p. 506-511, 2015/01
  • Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors, Surya Pandey,Taro Kawai,Shizuo Akira, COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, Vol. 7, No. 1, 2015/01
  • Regnase-1;a ribonuclease that controls the immune reaction, Shizuo Akira, 2014/11
  • RAB2Bは細胞質内二本鎖DNAによって誘導される抗ウイルス応答を制御する, Shizuo Akira,Tatsuya Saitoh, 2014/11
  • JAK2V617F(+) myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2, Yuki Kagoya,Akihide Yoshimi,Takako Tsuruta-Kishino,Shunya Arai,Takashi Satoh,Shizuo Akira,Mineo Kurokawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 124, No. 19, p. 2996-3006, 2014/11
  • B Cell-Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers, Chetna Soni,Eric B. Wong,Phillip P. Domeier,Tahsin N. Khan,Takashi Satoh,Shizuo Akira,Ziaur S. M. Rahman, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 193, No. 9, p. 4400-4414, 2014/11
  • An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth, Xuanming Shi,Zilai Zhang,Xiaoming Zhan,Mou Cao,Takashi Satoh,Shizuo Akira,Karl Shpargel,Terry Magnuson,Qingtian Li,Rongfu Wang,Chaochen Wang,Kai Ge,Jiang Wu, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 5, 2014/11
  • Regnase-1, an endoribonuclease involvled in the immune response, Shizuo Akira, 2014/10
  • Elucidation of anti-viral responses by reverse genetics, Shizuo Akira, 2014/10
  • オルガネラ傷害に起因するNLRP3インフラマソーム活性化メカニズムの解明, Shizuo Akira,Takuma Misawa,Tatsuya Saitoh, 2014/10
  • Akirin2 is critical for inducing inflammatory genes by bridging I kappa B-zeta and the SWI/SNF complex, Sarang Tartey,Kazufumi Matsushita,Alexis Vandenbon,Daisuke Ori,Tomoko Imamura,Takashi Mino,Daron M. Standley,Jules A. Hoffmann,Jean-Marc Reichhart,Shizuo Akira,Osamu Takeuchi, EMBO JOURNAL, WILEY, Vol. 33, No. 20, p. 2332-2348, 2014/10
  • Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia, Panagiotis Ntziachristos,Aristotelis Tsirigos,G. Grant Welstead,Thomas Trimarchi,Sofia Bakogianni,Luyao Xu,Evangelia Loizou,Linda Holmfeldt,Alexandros Strikoudis,Bryan King,Jasper Mullenders,Jared Becksfort,Jelena Nedjic,Elisabeth Paietta,Martin S. Tallman,Jacob M. Rowe,Giovanni Tonon,Takashi Satoh,Laurens Kruidenier,Rab Prinjha,Shizuo Akira,Pieter Van Vlierberghe,Adolfo A. Ferrando,Rudolf Jaenisch,Charles G. Mullighan,Iannis Aifantis, NATURE, NATURE PUBLISHING GROUP, Vol. 514, No. 7523, p. 513-+, 2014/10
  • TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression, Silvia Stockinger,Claudia U. Duerr,Marcus Fulde,Tamas Dolowschiak,Johanna Pott,Ines Yang,Daniel Eibach,Fredrik Backhed,Shizuo Akira,Sebastian Suerbaum,Martijn Brugman,Mathias W. Hornef, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 193, No. 8, p. 4223-4234, 2014/10
  • Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux, Luigi Franchi,Tatjana Eigenbrod,Raul Munoz-Planillo,Ulas Ozkurede,Yun-Gi Kim,Arindam Chakrabarti,Michael Gale,Robert H. Silverman,Marco Colonna,Shizuo Akira,Gabriel Nunez, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 193, No. 8, p. 4214-4222, 2014/10
  • Regnase-1, a ribonuclease essential to the inflammatory and immune responses, Shizuo Akira, 2014/09
  • MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus, Lisa A. Reynolds,Yvonne Harcus,Katherine A. Smith,Lauren M. Webb,James P. Hewitson,Ewan A. Ross,Sheila Brown,Satoshi Uematsu,Shizuo Akira,David Gray,Mohini Gray,Andrew S. MacDonald,Adam F. Cunningham,Rick M. Maizels, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 193, No. 6, p. 2984-2993, 2014/09
  • Innate lymphoid cells regulate intestinal epithelial cell glycosylation, Yoshiyuki Goto,Takashi Obata,Jun Kunisawa,Shintaro Sato,Ivaylo I. Ivanov,Aayam Lamichhane,Natsumi Takeyama,Mariko Kamioka,Mitsuo Sakamoto,Takahiro Matsuki,Hiromi Setoyama,Akemi Imaoka,Satoshi Uematsu,Shizuo Akira,Steven E. Domino,Paulina Kulig,Burkhard Becher,Jean-Christophe Renauld,Chihiro Sasakawa,Yoshinori Umesaki,Yoshimi Benno,Hiroshi Kiyono, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 345, No. 6202, p. 1310-+, 2014/09
  • Tribbles Homo log 3 Attenuates Mammalian Target of Rapamycin Complex-2 Signaling and Inflammation in the Diabetic Kidney, Emily Borsting,Shalin V. Patel,Anne-Emilie Decleves,Sarah J. Lee,Qazi M. Rahman,Shizuo Akira,Joe Satriano,Kumar Sharma,Volker Vallon,Robyn Cunard, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, AMER SOC NEPHROLOGY, Vol. 25, No. 9, p. 2067-2078, 2014/09
  • TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis, Sayaka Inokuchi-Shimizu,Eek Joong Park,Yoon Seok Roh,Ling Yang,Bi Zhang,Jingyi Song,Shuang Liang,Michael Pimienta,Koji Taniguchi,Xuefeng Wu,Kinji Asahina,William Lagakos,Mason R. Mackey,Shizuo Akira,Mark H. Ellisman,Dorothy D. Sears,Jerrold M. Olefsky,Michael Karin,David A. Brenner,Ekihiro Seki, Journal of Clinical Investigation, American Society for Clinical Investigation, Vol. 124, No. 8, p. 3566-3578, 2014/08/01
  • Regnase-1, a ribonuclease involved in the control of immune responses, Shizuo Akira, 2014/07
  • Principles of innate immunity, Tsuneyasu Kaisho,Shizuo Akira, Rheumatology: Sixth Edition, Elsevier Inc., Vol. 1-2, p. 127-133, 2014/06/19
  • Epicutaneously applied Der p 2 induces a strong T(H)2-biased antibody response in C57BL/6 mice, independent of functional TLR4, C. Stremnitzer,K. Manzano-Szalai,P. Starkl,A. Willensdorfer,S. Schrom,J. Singer,U. Reichart,S. Akira,E. Jensen-Jarolim, ALLERGY, WILEY-BLACKWELL, Vol. 69, No. 6, p. 741-751, 2014/06
  • The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy, Jayoung Choi,Sunmin Park,Scott B. Biering,Elizabeth Selleck,Catherine Y. Liu,Xin Zhang,Naonobu Fujita,Tatsuya Saitoh,Shizuo Akira,Tamotsu Yoshimori,L. David Sibley,Seungmin Hwang,Herbert W. Virgin, IMMUNITY, CELL PRESS, Vol. 40, No. 6, p. 924-935, 2014/06
  • 自然免疫と炎症, Shizuo Akira, 2014/06
  • Regnase-1, an endoribonuclease regulating the immune response, Shizuo Akira, 2014/06
  • 微小管によるミトコンドリアの空間配置転換はNLRP3インフラマソームを活性化する, Takuma Misawa, 2014/06
  • Regnase-1, a ribonuclease involved in the control of immune responses, Shizuo Akira, 2014/06
  • 自然免疫の最近の進歩, Shizuo Akira, 2014/06
  • Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria., Hong Zhao,Taiki Aoshi,Satoru Kawai,Yuki Mori,Aki Konishi,Muge Ozkan,Yukiko Fujita,Yasunari Haseda,Mikiko Shimizu,Masako Kohyama,Kouji Kobiyama,Kei Eto,Junichi Nabekura,Toshihiro Horii,Tomoko Ishino,Masao Yuda,Hiroaki Hemmi,Tsuneyasu Kaisho,Shizuo Akira,Manabu Kinoshita,Koujiro Tohyama,Yoshichika Yoshioka,Ken J Ishii,Cevayir Coban, Cell host & microbe, Vol. 15, No. 5, p. 551-63, 2014/05/14
  • Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-kappa B Activation, Hisaaki Shinohara,Marcelo Behar,Kentaro Inoue,Michio Hiroshima,Tomoharu Yasuda,Takeshi Nagashima,Shuhei Kimura,Hideki Sanjo,Shiori Maeda,Noriko Yumoto,Sewon Ki,Shizuo Akira,Yasushi Sako,Alexander Hoffmann,Tomohiro Kurosaki,Mariko Okada-Hatakeyama, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 344, No. 6185, p. 760-764, 2014/05
  • Prospective signs of cleidocranial dysplasia in Cebpb deficiency, Boyen Huang,Katsu Takahashi,Ernest A. Jennings,Pongthorn Pumtang-on,Honoka Kiso,Yumiko Togo,Kazuyuki Saito,Manabu Sugai,Shizuo Akira,Akira Shimizu,Kazuhisa Bessho, JOURNAL OF BIOMEDICAL SCIENCE, BIOMED CENTRAL LTD, Vol. 21, No. 1, 2014/05
  • 自然免疫の最近の進歩, Shizuo Akira, 2014/05
  • Regnase-1-mediated regulation of the immune response, Shizuo Akira, 2014/05
  • Regnase-1, a ribonuclease essential for the control of immune responses, Shizuo Akira, 2014/05
  • Intrinsic Disorder Mediates Cooperative Signal Transduction in STIM1, Yukio Furukawa,Shunsuke Teraguchi,Takahisa Ikegami,Onur Dagliyan,Lin Jin,Damien Hall,Nikolay V. Dokholyan,Keiichi Namba,Shizuo Akira,Tomohiro Kurosaki,Yoshihiro Baba,Daron M. Standley, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 426, No. 10, p. 2082-2097, 2014/05
  • Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii, Jun Ohshima,Youngae Lee,Miwa Sasai,Tatsuya Saitoh,Ji Su Ma,Naganori Kamiyama,Yoshiharu Matsuura,Suh Pann-Ghill,Mikako Hayashi,Shigeyuki Ebisu,Kiyoshi Takeda,Shizuo Akira,Masahiro Yamamoto, Journal of Immunology, American Association of Immunologists, Vol. 192, No. 7, p. 3328-3335, 2014/04/01
  • Generation of colonic IgA-secreting cells in the caecal patch., Masahata K,Umemoto E,Kayama H,Kotani M,Nakamura S,Kurakawa T,Kikuta J,Gotoh K,Motooka D,Sato S,Higuchi T,Baba Y,Kurosaki T,Kinoshita M,Shimada Y,Kimura T,Okumura R,Takeda A,Tajima M,Yoshie O,Fukuzawa M,Kiyono H,Fagarasan S,Iida T,Ishii M,Takeda K, Nat Commun, Vol. 5, 2014/04
  • Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity, Kanako Kuniyoshi,Osamu Takeuchi,Surya Pandey,Takashi Satoh,Hidenori Iwasaki,Shizuo Akira,Taro Kawai, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 111, No. 15, p. 5646-5651, 2014/04
  • Nucleic acid sensing by T cells initiates Th2 cell differentiation, Takayuki Imanishi,Chitose Ishihara,Mohamed El Sherif Gadelhaq Badr,Akiko Hashimoto-Tane,Yayoi Kimura,Taro Kawai,Osamu Takeuchi,Ken J. Ishii,Shun'ichiro Taniguchi,Tetsuo Noda,Hisashi Hirano,Frank Brombacher,Glen N. Barber,Shizuo Akira,Takashi Saito, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 5, 2014/04
  • The Enzyme Cyp26b1 Mediates Inhibition of Mast Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis, Yosuke Kurashima,Takeaki Amiya,Kumiko Fujisawa,Naoko Shibata,Yuji Suzuki,Yuta Kogure,Eri Hashimoto,Atsushi Otsuka,Kenji Kabashima,Shintaro Sato,Takeshi Sato,Masato Kubo,Shizuo Akira,Kensuke Miyake,Jun Kunisawa,Hiroshi Kiyono, IMMUNITY, CELL PRESS, Vol. 40, No. 4, p. 530-541, 2014/04
  • Regnase-1, a ribonuclease involved in the immune regulation, Shizuo Akira, 2014/04
  • RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma, Adeline R. Lam,Nina Le Bert,Samantha S. W. Ho,Yu J. Shen,Melissa L. F. Tang,Gordon M. Xiong,J. Ludovic Croxford,Christine X. Koo,Ken J. Ishii,Shizuo Akira,David H. Raulet,Stephan Gasser, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 74, No. 8, p. 2193-2203, 2014/04
  • Humoral Immunity and CD4(+) Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis, Marie-Alice Vitry,Delphine Hanot Mambres,Carl De Trez,Shizuo Akira,Bernhard Ryffel,Jean-Jacques Letesson,Eric Muraille, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, No. 8, p. 3740-3752, 2014/04
  • Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome, Naoki Takemura,Takumi Kawasaki,Jun Kunisawa,Shintaro Sato,Aayam Lamichhane,Kouji Kobiyama,Taiki Aoshi,Junichi Ito,Kenji Mizuguchi,Thangaraj Karuppuchamy,Kouta Matsunaga,Shoichiro Miyatake,Nobuko Mori,Tohru Tsujimura,Takashi Satoh,Yutaro Kumagai,Taro Kawai,Daron M. Standley,Ken J. Ishii,Hiroshi Kiyono,Shizuo Akira,Satoshi Uematsu, Nature Communications, Nature Publishing Group, Vol. 5, 2014/03/18
  • TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching, Erin Janssen,Esra Ozcan,Kyriaki Liadaki,Haifa H. Jabara,John Manis,Sumana Ullas,Shizuo Akira,Katherine A. Fitzgerald,Douglas T. Golenbock,Raif S. Geha, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, No. 6, p. 2651-2658, 2014/03
  • Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice, Christine Koulis,Yung-Chih Chen,Christian Hausding,Ingo Ahrens,Tin Soe Kyaw,Christopher Tay,Terri Allen,Karin Jandeleit-Dahm,Matthew J. Sweet,Shizuo Akira,Alexander Bobik,Karlheinz Peter,Alex Agrotis, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 34, No. 3, p. 516-525, 2014/03
  • RIG-I Detects mRNA of Intracellular Salmonella enterica Serovar Typhimurium during Bacterial Infection, Mirco Schmolke,Jenish R. Patel,Elisa de Castro,Maria T. Sanchez-Aparicio,Melissa B. Uccellini,Jennifer C. Miller,Balaji Manicassamy,Takashi Satoh,Taro Kawai,Shizuo Akira,Miriam Merad,Adolfo Garcia-Sastre, MBIO, AMER SOC MICROBIOLOGY, Vol. 5, No. 2, p. e01006-e01014, 2014/03
  • Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist, Kouji Kobiyama,Taiki Aoshi,Hirotaka Narita,Etsushi Kuroda,Masayuki Hayashi,Kohhei Tetsutani,Shohei Koyama,Shinichi Mochizuki,Kazuo Sakurai,Yuko Katakai,Yasuhiro Yasutomi,Shinobu Saijo,Yoichiro Iwakura,Shizuo Akira,Cevayir Coban,Ken J. Ishii, Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 8, p. 3086-3091, 2014/02/25
  • Prevention of Intestinal Allergy in Mice by rflaA: Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC, Stefan Schuelke,Sonja Wolfheimer,Gabriele Gadermaier,Andrea Wangorsch,Susanne Siebeneicher,Peter Briza,Ingo Spreitzer,Dirk Schiller,Bettina Loeschner,Satoshi Uematsu,Bernard Ryffel,Shizuo Akira,Zoe Waibler,Stefan Vieths,Masako Toda,Stephan Scheurer, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 9, No. 2, 2014/02
  • Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells, Chikako Ono,Akinori Ninomiya,Satomi Yamamoto,Takayuki Abe,Xiauyu Wen,Takasuke Fukuhara,Miwa Sasai,Masahiro Yamamoto,Tatsuya Saitoh,Takashi Satoh,Taro Kawai,Ken J. Ishii,Shizuo Akira,Toru Okamoto,Yoshiharu Matsuura, Journal of Virology, Vol. 88, No. 4, p. 2157-2167, 2014/02
  • The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity, J. A. Wali,D. Rondas,M. D. McKenzie,Y. Zhao,L. Elkerbout,S. Fynch,E. N. Gurzov,S. Akira,C. Mathieu,T. W.H. Kay,L. Overbergh,A. Strasser,H. E. Thomas, Cell Death and Disease, Nature Publishing Group, Vol. 5, No. 3, 2014
  • CD103-CD11b+dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin, S. M. Atif,S. Uematsu,S. Akira,S. J. McSorley, MUCOSAL IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 7, No. 1, p. 68-77, 2014/01
  • Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice, Y. H. Connie Leung,John M. Nicholls,Chuk Kwan Ho,Sin Fun Sia,Chris K. P. Mok,Sophie A. Valkenburg,Peter Cheung,Kenrie P. Y. Hui,Renee W. Y. Chan,Y. Guan,S. Akira,J. S. Malik Peiris, Journal of General Virology, Society for General Microbiology, Vol. 95, No. 9, p. 1870-1879, 2014
  • The Early Activation of CD8(+) T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector, Masahisa Hemmi,Masashi Tachibana,Sayaka Tsuzuki,Masaki Shoji,Fuminori Sakurai,Kenji Kawabata,Kouji Kobiyama,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, Vol. 2014, No. Pathology, 2014
  • Autophagy proteins control goblet cell function by potentiating reactive oxygen species production, Khushbu K. Patel,Hiroyuki Miyoshi,Wandy L. Beatty,Richard D. Head,Nicole P. Malvin,Ken Cadwell,Jun-Lin Guan,Tatsuya Saitoh,Shizuo Akira,Per O. Seglen,Mary C. Dinauer,Herbert W. Virgin,Thaddeus S. Stappenbeck, EMBO Journal, Vol. 32, No. 24, p. 3130-3144, 2013/12/11
  • Prostaglandin E-2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production, Kazunari Sugita,Atsuko Ikenouchi-Sugita,Yasuko Nakayama,Haruna Yoshioka,Takashi Nomura,Jun-ichi Sakabe,Kyoko Nakahigashi,Etsushi Kuroda,Satoshi Uematsu,Jun Nakamura,Shizuo Akira,Motonobu Nakamura,Shuh Narumiya,Yoshiki Miyachi,Yoshiki Tokura,Kenji Kabashima, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 3, 2013/10
  • Autophagy in infection, inflammation and immunity, Vojo Deretic,Tatsuya Saitoh,Shizuo Akira, Nature Reviews Immunology, Vol. 13, No. 10, p. 722-737, 2013/10
  • The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation, Jianhui Ma,Bo Ram Bang,Jiawei Lu,So Young Eun,Motoyuki Otsuka,Michael Croft,Peter Tobias,Jiahuai Han,Osamu Takeuchi,Shizuo Akira,Michael Karin,Hideo Yagita,Young Jun Kang, Science Signaling, Vol. 6, No. 295, 2013/10/01
  • DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant., Nyström S,Bråve A,Falkeborn T,Devito C,Rissiek B,Johansson DX,Schröder U,Uematsu S,Akira S,Hinkula J,Applequist SE, Vaccines, Vol. 1, No. 4, p. 415-443, 2013/09
  • Macrophages control innate inflammation, S. Akira,T. Misawa,T. Satoh,T. Saitoh, Diabetes, Obesity and Metabolism, Vol. 15, No. 3, p. 10-18, 2013/09
  • Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model, Chung Truong Nguyen,Seol Hee Hong,Jeong-Im Sin,Hong Van Dinh Vu,Kwangjoon Jeong,Kyoung Oh Cho,Satoshi Uematsu,Shizuo Akira,Shee Eun Lee,Joon Haeng Rhee, Vaccine, Vol. 31, No. 37, p. 3879-3887, 2013/08/20
  • The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling, Takumi Kawasaki,Naoki Takemura,Daron M. Standley,Shizuo Akira,Taro Kawai, Cell Host and Microbe, Cell Press, Vol. 14, No. 2, p. 148-158, 2013/08/14
  • Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury, Ikuko Maejima,Atsushi Takahashi,Hiroko Omori,Tomonori Kimura,Yoshitsugu Takabatake,Tatsuya Saitoh,Akitsugu Yamamoto,Maho Hamasaki,Takeshi Noda,Yoshitaka Isaka,Tamotsu Yoshimori, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 32, No. 17, p. 2336-2347, 2013/08
  • Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus, Hanna Lee,Jun Komano,Yasunori Saitoh,Shoji Yamaoka,Tatsuya Kozaki,Takuma Misawa,Michihiro Takahama,Takashi Satoh,Osamu Takeuchi,Naoki Yamamoto,Yoshiharu Matsuurag,Tatsuya Saitoh,Shizuo Akira, Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 30, p. 12379-12384, 2013/07/23
  • Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus, Jae Hee Lee,Tae Hoon Kim,Seo Jin Oh,Jung-Yoon Yoo,Shizuo Akira,Bon Jeong Ku,John P. Lydon,Jae-Wook Jeong, FASEB Journal, Vol. 27, No. 7, p. 2553-2563, 2013/07
  • Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus., Lee H,Komano J,Saitoh Y,Yamaoka S,Kozaki T,Misawa T,Takahama M,Satoh T,Takeuchi O,Yamamoto N,Matsuura Y,Saitoh T,Akira S, Proc Natl Acad Sci U S A, Vol. 110, No. 30, p. 12379-12384, 2013/07
  • Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis, Anna M. Lundberg,Daniel F. J. Ketelhuth,Maria E. Johansson,Norbert Gerdes,Sang Liu,Masahiro Yamamoto,Shizuo Akira,Goran K. Hansson, CARDIOVASCULAR RESEARCH, OXFORD UNIV PRESS, Vol. 99, No. 2, p. 364-373, 2013/07
  • Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model, Yoshiharu Akitake,Yoshihito Nakatani,Daisuke Kamei,Masato Hosokawa,Hiroyasu Akatsu,Satoshi Uematsu,Shizuo Akira,Ichiro Kudo,Shuntaro Hara,Mitsuo Takahashi, Journal of Neuroscience Research, Vol. 91, No. 7, p. 909-919, 2013/07
  • Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β, Tadaomi Kawashima,Akemi Kosaka,Huimin Yan,Zijin Guo,Ryosuke Uchiyama,Ryutaro Fukui,Daisuke Kaneko,Yutaro Kumagai,Dong Ju You,Joaquim Carreras,Satoshi Uematsu,Myoung Ho Jang,Osamu Takeuchi,Tsuneyasu Kaisho,Shizuo Akira,Kensuke Miyake,Hiroko Tsutsui,Takashi Saito,Ikuko Nishimura,Noriko M. Tsuji, Immunity, Vol. 38, No. 6, p. 1187-1197, 2013/06/27
  • Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance, Nagatoshi Fujiwara,Steven A. Porcelli,Takashi Naka,Ikuya Yano,Shinji Maeda,Hirotaka Kuwata,Shizuo Akira,Satoshi Uematsu,Takemasa Takii,Hisashi Ogura,Kazuo Kobayashi, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ELSEVIER SCIENCE BV, Vol. 1831, No. 6, p. 1177-1184, 2013/06
  • Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation, Masahiro Fukasaka,Daisuke Ori,Tatsukata Kawagoe,Satoshi Uematsu,Kenta Maruyama,Toshihiko Okazaki,Tatsuya Kozaki,Tomoko Imamura,Sarang Tartey,Takashi Mino,Takashi Satoh,Shizuo Akira,Osamu Takeuchi, Journal of Immunology, Vol. 190, No. 11, p. 5702-5711, 2013/06/01
  • XMalt1-induced cleavage of regnase-1 in CD4<sup>+</sup> helper T cells regulates immune activation, Takuya Uehata,Hidenori Iwasaki,Alexis Vandenbon,Kazufumi Matsushita,Eduardo Hernandez-Cuellar,Kanako Kuniyoshi,Takashi Satoh,Takashi Mino,Yutaka Suzuki,Daron M. Standley,Tohru Tsujimura,Hiromi Rakugi,Yoshitaka Isaka,Osamu Takeuchi,Shizuo Akira, Cell, Vol. 153, No. 5, p. 1036-1049, 2013/05/23
  • Intestinal Lin(-)c-Kit(+)NKp46(-)CD4(-) Population Strongly Produces IL-22 upon IL-1 beta Stimulation, Youngae Lee,Yutaro Kumagai,Min Seong Jang,Jung-Hwan Kim,Bo-Gie Yang,Eun-Jung Lee,You-Me Kim,Shizuo Akira,Myoung Ho Jang, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, No. 10, p. 5296-5305, 2013/05
  • Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice, Gerard E. Kaiko,Zhixuan Loh,Kirsten Spann,Jason P. Lynch,Amit Lalwani,Zhenglong Zheng,Sophia Davidson,Satoshi Uematsu,Shizuo Akira,John Hayball,Kerrilyn R. Diener,Katherine J. Baines,Jodie L. Simpson,Paul S. Foster,Simon Phipps, Journal of Allergy and Clinical Immunology, Vol. 131, No. 5, p. 1331-e10, 2013/05
  • Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome, Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Hanna Lee,Jian Zou,Tatsuya Saitoh,Shizuo Akira, Nature Immunology, Springer Science and Business Media LLC, Vol. 14, No. 5, p. 454-460, 2013/05
  • Poly ic triggers a cathepsin d- and ips-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis, Jian Zou,Taro Kawai,Tetsuo Tsuchida,Tatsuya Kozaki,Hiroki Tanaka,Kyung-Sue Shin,Himanshu Kumar,Shizuo Akira, Immunity, Vol. 38, No. 4, p. 717-728, 2013/04/18
  • IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation, Hilary Sandig,Catherine E. Jobbings,Nestor Gonzalez Roldan,Jayde K. Whittingham-Dowd,Zane Orinska,Osamu Takeuchi,Shizuo Akira,Silvia Bulfone-Paus, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, Vol. 43, No. 4, p. 979-988, 2013/04
  • Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs, Daisuke Ori,Hiroki Kato,Hideki Sanjo,Sarang Tartey,Takashi Mino,Shizuo Akira,Osamu Takeuchi, Journal of Immunology, Vol. 190, No. 8, p. 4037-4045, 2013/04
  • Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages, Takashi Satoh,Hiroyasu Kidoya,Hisamichi Naito,Masahiro Yamamoto,Naoki Takemura,Katsuhiro Nakagawa,Yoshichika Yoshioka,Eiichi Morii,Nobuyuki Takakura,Osamu Takeuchi,Shizuo Akira, Nature, Vol. 495, No. 7442, p. 524-528, 2013/03/28
  • Enhanced Apoptosis by Disruption of the STAT3-IκB-ζ Signaling Pathway in Epithelial Cells Induces Sjögren's Syndrome-like Autoimmune Disease, Atsushi Okuma,Katsuaki Hoshino,Tomoyuki Ohba,Sawako Fukushi,Setsuya Aiba,Shizuo Akira,Masao Ono,Tsuneyasu Kaisho,Tatsushi Muta, Immunity, Vol. 38, No. 3, p. 450-460, 2013/03/21
  • The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant, Choon Kit Tang,Taiki Aoshi,Nao Jounai,Junichi Ito,Keiichi Ohata,Kouji Kobiyama,Benoit H. Dessailly,Etsushi Kuroda,Shizuo Akira,Kenji Mizuguchi,Cevayir Coban,Ken J. Ishii, PLoS ONE, Vol. 8, No. 3, 2013/03/21
  • Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process, B. Huang,K. Takahashi,T. Sakata-Goto,H. Kiso,Y. Togo,K. Saito,H. Tsukamoto,M. Sugai,S. Akira,A. Shimizu,K. Bessho, Oral Diseases, Vol. 19, No. 2, p. 144-150, 2013/03
  • Commensal microbiota drive proliferation of conventional and Foxp3(+) regulatory CD4(+) T cells in mesenteric lymph nodes and Peyer's patches., Cording S,Fleissner D,Heimesaat MM,Bereswill S,Loddenkemper C,Uematsu S,Akira S,Hamann A,Huehn J, European journal of microbiology & immunology, Vol. 3, No. 1, p. 1-10, 2013/03
  • FIP200 regulates targeting of Atg16L1 to the isolation membrane, Taki Nishimura,Takeshi Kaizuka,Ken Cadwell,Mayurbhai H. Sahani,Tatsuya Saitoh,Shizuo Akira,Herbert W. Virgin,Noboru Mizushima, EMBO Reports, Vol. 14, No. 3, p. 284-291, 2013/03
  • DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking., Takeshi Kondo,Junya Kobayashi,Tatsuya Saitoh,Kenta Maruyama,Ken J Ishii,Glen N Barber,Kenshi Komatsu,Shizuo Akira,Taro Kawai, Proceedings of the National Academy of Sciences of the United States of America, 8, Vol. 110, No. 8, p. 2969-74, 2013/02/19
  • Toll-Like Receptors, H. Kumar,O. Takeuchi,S. Akira, Encyclopedia of Biological Chemistry: Second Edition, p. 396-401, 2013/02/15
  • Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza, Daisuke Fujikura,Satoko Chiba,Daisuke Muramatsu,Mika Kazumata,Yosuke Nakayama,Taro Kawai,Shizuo Akira,Hiroshi Kida,Tadaaki Miyazaki, PLoS ONE, Vol. 8, No. 2, 2013/02/08
  • Innate immunity, Jules Hoffmann,Shizuo Akira, Current Opinion in Immunology, Vol. 25, No. 1, p. 1-3, 2013/02
  • Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis, Chisen Takeuchi,Yoh Matsumoto,Kuniko Kohyama,Satoshi Uematsu,Shizuo Akira,Kanato Yamagata,Takako Takemiya, NEUROCHEMISTRY INTERNATIONAL, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 62, No. 3, p. 271-280, 2013/02
  • Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii, A. Alicia Koblansky,Dragana Jankovic,Hyunju Oh,Sara Hieny,Waradon Sungnak,Ramkumar Mathur,Matthew S. Hayden,Shizuo Akira,Alan Sher,Sankar Ghosh, Immunity, Vol. 38, No. 1, p. 119-130, 2013/01/24
  • FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration, Hinako M. Takase,Tohru Itoh,Seitaro Ino,Ting Wang,Takehiko Koji,Shizuo Akira,Yasuhiro Takikawa,Atsushi Miyajima, Genes and Development, Vol. 27, No. 2, p. 169-181, 2013
  • TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza a virus infection, Sabine Stegemann-Koniszewski,Marcus Gereke,Sofia Orrskog,Stefan Lienenklaus,Bastian Pasche,Sophie R. Bader,Achim D. Gruber,Shizuo Akira,Siegfried Weiss,Birgitta Henriques-Normark,Dunja Bruder,Matthias Gunzer, Journal of Innate Immunity, S. Karger AG, Vol. 5, No. 1, p. 84-96, 2013
  • CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin, Akihiko Ichikawa,Keiji Kuba,Masayuki Morita,Shinsuke Chida,Hiroyuki Tezuka,Hiromitsu Hara,Takehiko Sasaki,Toshiaki Ohteki,V. Marco Ranieri,Claudia C. dos Santos,Yoshihiro Kawaoka,Shizuo Akira,Andrew D. Luster,Bao Lu,Josef M. Penninger,Stefan Uhlig,Arthur S. Slutsky,Yumiko Imai, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, Vol. 187, No. 1, p. 65-77, 2013/01
  • Completion of the entire hepatitis C virus life cycle in genetically humanized mice, Marcus Dorner,Joshua A. Horwitz,Bridget M. Donovan,Rachael N. Labitt,William C. Budell,Tamar Friling,Alexander Vogt,Maria Teresa Catanese,Takashi Satoh,Taro Kawai,Shizuo Akira,Mansun Law,Charles M. Rice,Alexander Ploss, Nature, Vol. 501, No. 7466, p. 237-241, 2013
  • Physiological role and differentiation mechanism of various M2 macrophages, Takashi Satoh,Shizuo Akira, Japanese Journal of Allergology, Japanese Society of Allergology, Vol. 62, No. 12, p. 1575-1582, 2013
  • A Parzen window-based approach for the detection of locally enriched transcription factor binding sites, Alexis Vandenbon,Yutaro Kumagai,Shunsuke Teraguchi,Karlou Mar Amada,Shizuo Akira,Daron M. Standley, BMC BIOINFORMATICS, BMC, Vol. 14, 2013/01
  • Ifit1 inhibits japanese encephalitis virus replication through binding to 5= capped 2'-o unmethylated RNA, Taishi Kimura,Hiroshi Katoh,Hisako Kayama,Hiroyuki Saiga,Megumi Okuyama,Toru Okamoto,Eiji Umemoto,Yoshiharu Matsuur,Masahiro Yamamoto,Kiyoshi Takeda, Journal of Virology, Vol. 87, No. 18, p. 9997-10003, 2013
  • Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP, Kenta Maruyama,Satoshi Uematsu,Takeshi Kondo,Osamu Takeuchi,Mikaël M. Martino,Takumi Kawasaki,Shizuo Akira, Journal of Experimental Medicine, Vol. 210, No. 10, p. 1947-1960, 2013
  • Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin, Naonobu Fujita,Eiji Morita,Takashi Itoh,Atsushi Tanaka,Megumi Nakaoka,Yuki Osada,Tetsuo Umemoto,Tatsuya Saitoh,Hitoshi Nakatogawa,Shouhei Kobayashi,Tokuko Haraguchi,Jun-Lin Guan,Kazuhiro Iwai,Fuminori Tokunaga,Kazunobu Saito,Koutaro Ishibashi,Shizuo Akira,Mitsunori Fukuda,Takeshi Noda,Tamotsu Yoshimori, Journal of Cell Biology, Vol. 203, No. 1, p. 115-128, 2013
  • Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice, Jun Kunisawa,Masashi Gohda,Eri Hashimoto,Izumi Ishikawa,Morio Higuchi,Yuji Suzuki,Yoshiyuki Goto,Casandra Panea,Ivaylo I. Ivanov,Risa Sumiya,Lamichhane Aayam,Taichi Wake,So Tajiri,Yosuke Kurashima,Shiori Shikata,Shizuo Akira,Kiyoshi Takeda,Hiroshi Kiyono, Nature Communications, Vol. 4, 2013
  • Regnase-1, a ribonuclease involved in the regulation of immune responses, Shizuo Akira, Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, Vol. 78, No. 1, p. 51-60, 2013
  • Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node, Adriana Flores-Langarica,Jennifer L. Marshall,Jessica Hitchcock,Charlotte Cook,Jonathan Jobanputra,Saeeda Bobat,Ewan A. Ross,Ruth E. Coughlan,Ian R. Henderson,Satoshi Uematsu,Shizuo Akira,Adam F. Cunningham, Journal of Immunology, Vol. 189, No. 12, p. 5745-5754, 2012/12/15
  • The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation, Kenta Maruyama,Masahiro Fukasaka,Alexis Vandenbon,Tatsuya Saitoh,Takumi Kawasaki,Takeshi Kondo,Kazunari K. Yokoyama,Hiroyasu Kidoya,Nobuyuki Takakura,Daron Standley,Osamu Takeuchi,Shizuo Akira, Immunity, Vol. 37, No. 6, p. 1024-1036, 2012/12/14
  • Cutting edge: Nitric oxide inhibits the NLRP3 inflammasome, Eduardo Hernandez-Cuellar,Kohsuke Tsuchiya,Hideki Hara,Rendong Fang,Shunsuke Sakai,Ikuo Kawamura,Shizuo Akira,Masao Mitsuyama, Journal of Immunology, Vol. 189, No. 11, p. 5113-5117, 2012/12/01
  • Crucial Role of Gamma Interferon-Producing CD4(+) Th1 Cells but Dispensable Function of CD8(+) T Cell, B Cell, Th2, and Th17 Responses in the Control of Brucella melitensis Infection in Mice, Marie-Alice Vitry,Carl De Trez,Stanislas Goriely,Laure Dumoutier,Shizuo Akira,Bernhard Ryffel,Yves Carlier,Jean-Jacques Letesson,Eric Muraille, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 80, No. 12, p. 4271-4280, 2012/12
  • IPS-1 Signaling Has a Nonredundant Role in Mediating Antiviral Responses and the Clearance of Respiratory Syncytial Virus, Tine Demoor,Bryan C. Petersen,Susan Morris,Sumanta Mukherjee,Catherine Ptaschinski,Denise E. De Almeida Nagata,Taro Kawai,Toshihiro Ito,Shizuo Akira,Steven L. Kunkel,Matthew A. Schaller,Nicholas W. Lukacs, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 189, No. 12, p. 5942-5953, 2012/12
  • Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction, Minoru Shigekawa,Hayato Hikita,Takahiro Kodama,Satoshi Shimizu,Wei Li,Akio Uemura,Takuya Miyagi,Atsushi Hosui,Tatsuya Kanto,Naoki Hiramatsu,Tomohide Tatsumi,Kiyoshi Takeda,Shizuo Akira,Tetsuo Takehara, American Journal of Pathology, Vol. 181, No. 6, p. 2105-2113, 2012/12
  • A novel unbiased measure for motif co-occurrence predicts combinatorial regulation of transcription, Alexis Vandenbon,Yutaro Kumagai,Shizuo Akira,Daron M. Standley, BMC GENOMICS, BMC, Vol. 13, 2012/12
  • Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism, Hong Zhao,Aki Konishi,Yukiko Fujita,Masanori Yagi,Keiichi Ohata,Taiki Aoshi,Sawako Itagaki,Shintaro Sato,Hirotaka Narita,Noha H. Abdelgelil,Megumi Inoue,Richard Culleton,Osamu Kaneko,Atsushi Nakagawa,Toshihiro Horii,Shizuo Akira,Ken J. Ishii,Cevayir Coban, Cell Host and Microbe, Vol. 12, No. 5, p. 705-716, 2012/11/15
  • A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability, Stephanie L. Moon,John R. Anderson,Yutaro Kumagai,Carol J. Wilusz,Shizuo Akira,Alexander A. Khromykh,Jeffrey Wilusz, RNA-A PUBLICATION OF THE RNA SOCIETY, COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, Vol. 18, No. 11, p. 2029-2040, 2012/11
  • [Physiological roles and differentiation mechanism of M2 macrophage]., Satoh T,Akira S, Nihon rinsho. Japanese journal of clinical medicine, Vol. 70 Suppl 8, p. 236-241, 2012/11
  • Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure (vol 485, pg 251, 2012), Oka Takafumi,Hikoso Shungo,Yamaguchi Osamu,Taneike Manabu,Takeda Toshihiro,Tamai Takahito,Oyabu Jota,Murakawa Tomokazu,Nakayama Hiroyuki,Nishida Kazuhiko,Akira Shizuo,Yamamoto Akitsugu,Komuro Issei,Otsu Kinya, NATURE, Vol. 490, No. 7419, 2012/10/11
  • PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells, Takuma Shibata,Naoki Takemura,Yuji Motoi,Yoshiyuki Goto,Thangaraj Karuppuchamy,Kumi Izawa,Xiaobing Li,Sachiko Akashi-takamura,Natsuko Tanimura,Jun Kunisawa,Hiroshi Kiyono,Shizuo Akira,Toshio Kitamura,Jiro Kitaura,Satoshi Uematsu,Kensuke Miyake, International Immunology, Vol. 24, No. 10, p. 613-623, 2012/10
  • Distinct Modulated Pupil Function System for Real-Time Imaging of Living Cells, Tomonobu M. Watanabe,Yoshikazu Tsukasaki,Hideaki Fujita,Taro Ichimura,Tatsuya Saitoh,Shizuo Akira,Toshio Yanagida, PLoS ONE, Vol. 7, No. 9, 2012/09/04
  • Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock, Penny A. Rudd,Jane Wilson,Joy Gardner,Thibaut Larcher,Candice Babarit,Thuy T. Le,Itaru Anraku,Yutaro Kumagai,Yueh-Ming Loo,Michael Gale,Shizuo Akira,Alexander A. Khromykh,Andreas Suhrbier, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 86, No. 18, p. 9888-9898, 2012/09
  • Systems biology approaches to toll-like receptor signaling, Alexis Vandenbon,Shunsuke Teraguchi,Shizuo Akira,Kiyoshi Takeda,Daron M. Standley, WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, WILEY, Vol. 4, No. 5, p. 497-507, 2012/09
  • Dissecting negative regulation of Toll-like receptor signaling, Takeshi Kondo,Taro Kawai,Shizuo Akira, Trends in Immunology, Vol. 33, No. 9, p. 449-458, 2012/09
  • A cluster of interferon-γ-inducible p65 gtpases plays a critical role in host defense against toxoplasma gondii, Masahiro Yamamoto,Megumi Okuyama,Ji Su Ma,Taishi Kimura,Naganori Kamiyama,Hiroyuki Saiga,Jun Ohshima,Miwa Sasai,Hisako Kayama,Toru Okamoto,David C.S. Huang,Dominique Soldati-Favre,Kyoji Horie,Junji Takeda,Kiyoshi Takeda, Immunity, Vol. 37, No. 2, p. 302-313, 2012/08/24
  • Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa, Masaki Shoji,Masashi Tachibana,Kazufumi Katayama,Kyoko Tomita,Sayaka Tsuzuki,Fuminori Sakurai,Kenji Kawabata,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, Biochemical and Biophysical Research Communications, Vol. 425, No. 1, p. 89-93, 2012/08/17
  • TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation, Kenta Maruyama,Tatsukata Kawagoe,Takeshi Kondo,Shizuo Akira,Osamu Takeuchi, Journal of Biological Chemistry, Vol. 287, No. 34, p. 29114-29124, 2012/08/17
  • Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35, Yukiko Kuroki,Yuka Sasaki,Daisuke Kamei,Yoshiharu Akitake,Mitsuo Takahashi,Satoshi Uematsu,Shizuo Akira,Yoshihito Nakatani,Ichiro Kudo,Shuntaro Hara, Biochemical and Biophysical Research Communications, Vol. 424, No. 3, p. 409-413, 2012/08/03
  • TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification, Marina Oldenburg,Anne Krueger,Ruth Ferstl,Andreas Kaufmann,Gernot Nees,Anna Sigmund,Barbara Bathke,Henning Lauterbach,Mark Suter,Stefan Dreher,Uwe Koedel,Shizuo Akira,Taro Kawai,Jan Buer,Hermann Wagner,Stefan Bauer,Hubertus Hochrein,Carsten J. Kirschning, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 337, No. 6098, p. 1111-1115, 2012/08
  • Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis, Jennifer L. Berard,Juan G. Zarruk,Nathalie Arbour,Alexandre Prat,V. Wee Yong,Francois H. Jacques,Shizuo Akira,Samuel David, GLIA, WILEY, Vol. 60, No. 7, p. 1145-1159, 2012/07
  • Leukemia Inhibitory Factor Coordinates the Down-regulation of the Visual Cycle in the Retina and Retinal-pigmented Epithelium, Ana J. Chucair-Elliott,Michael H. Elliott,Jiangang Wang,Gennadiy P. Moiseyev,Jian-Xing Ma,Luis E. Politi,Nora P. Rotstein,Shizuo Akira,Satoshi Uematsu,John D. Ash, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 287, No. 29, p. 24092-24102, 2012/07
  • Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity, Martin Kreutz,Benoit Giquel,Qin Hu,Ram Abuknesha,Satoshi Uematsu,Shizuo Akira,Frank O. Nestle,Sandra S. Diebold, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 7, No. 7, 2012/07
  • A critical role of IL-33 in experimental allergic rhinitis, Yoko Haenuki,Kazufumi Matsushita,Shizue Futatsugi-Yumikura,Ken J. Ishii,Tatsukata Kawagoe,Yoshimasa Imoto,Shigeharu Fujieda,Makoto Yasuda,Yasuo Hisa,Shizuo Akira,Kenji Nakanishi,Tomohiro Yoshimoto, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 130, No. 1, p. 184-+, 2012/07
  • Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1, Tatsuya Saitoh,Jun Komano,Yasunori Saitoh,Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Takuya Uehata,Hidenori Iwasaki,Hiroko Omori,Shoji Yamaoka,Naoki Yamamoto,Shizuo Akira, Cell Host & Microbe, Elsevier BV, Vol. 12, No. 1, p. 109-116, 2012/07
  • Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis., Shoichi Ihara,Hiroshi Kida,Hisashi Arase,Lokesh P Tripathi,Yi-An Chen,Tetsuya Kimura,Mitsuhiro Yoshida,Yozo Kashiwa,Haruhiko Hirata,Reiko Fukamizu,Ruriko Inoue,Kana Hasegawa,Sho Goya,Ryo Takahashi,Toshiyuki Minami,Kazuyuki Tsujino,Mayumi Suzuki,Satoshi Kohmo,Koji Inoue,Izumi Nagatomo,Yoshito Takeda,Takashi Kijima,Kenji Mizuguchi,Isao Tachibana,Atsushi Kumanogoh, Cancer research, Vol. 72, No. 12, p. 2990-9, 2012/06/15
  • Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis, Y. Sasaki,D. Kamei,Y. Ishikawa,T. Ishii,S. Uematsu,S. Akira,M. Murakami,S. Hara, Oncogene, Vol. 31, No. 24, p. 2943-2952, 2012/06/14
  • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain, Takashi Shichita,Eiichi Hasegawa,Akihiro Kimura,Rimpei Morita,Ryota Sakaguchi,Ichiro Takada,Takashi Sekiya,Hiroaki Ooboshi,Takanari Kitazono,Toru Yanagawa,Tetsuro Ishii,Hideo Takahashi,Shuji Mori,Masahiro Nishibori,Kazumichi Kuroda,Shizuo Akira,Kensuke Miyake,Akihiko Yoshimura, Nature Medicine, Vol. 18, No. 6, p. 911-917, 2012/06
  • [Nucleic acids recognition by innate immunity]., Akira S,Saitoh T,Kawai T, Uirusu, Vol. 62, No. 1, p. 39-45, 2012/06
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  • In Situ Microscopy Analysis Reveals Local Innate Immune Response Developed around Brucella Infected Cells in Resistant and Susceptible Mice, Richard Copin,Marie-Alice Vitry,Delphine Hanot Mambres,Arnaud Machelart,Carl De Trez,Jean-Marie Vanderwinden,Stefan Magez,Shizuo Akira,Bernhard Ryffel,Yves Carlier,Jean-Jacques Letesson,Eric Muraille, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 8, No. 3, 2012/03
  • Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice, Koubun Yasuda,Taichiro Muto,Tatsukata Kawagoe,Makoto Matsumoto,Yuki Sasaki,Kazufumi Matsushita,Yuko Taki,Shizue Futatsugi-Yumikura,Hiroko Tsutsui,Ken J. Ishii,Tomohiro Yoshimoto,Shizuo Akira,Kenji Nakanishi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, p. 3451-3456, 2012/02/28
  • Role of TLRs in Brucella mediated murine DC activation in vitro and clearance of pulmonary infection in vivo, Naveen Surendran,Elizabeth M. Hiltbold,Bettina Held,Shizuo Akira,Theodore J. Standiford,Nammalwar Sriranganathan,Stephen M. Boyle,Kurt L. Zimmerman,Melissa R. Makris,Sharon G. Witonsky, VACCINE, ELSEVIER SCI LTD, Vol. 30, No. 8, p. 1502-1512, 2012/02
  • Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system, Eddy T. H. Goh,J. Simon C. Arthur,Peter C. F. Cheung,Shizuo Akira,Rachel Toth,Philip Cohen, BIOCHEMICAL JOURNAL, PORTLAND PRESS LTD, Vol. 441, p. 339-346, 2012/01
  • Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS, Angela Dann,Hendrik Poeck,Andrew L. Croxford,Stefanie Gaupp,Katrin Kierdorf,Markus Knust,Dietmar Pfeifer,Cornelius Maihoefer,Stefan Endres,Ulrich Kalinke,Sven G. Meuth,Heinz Wiendl,Klaus-Peter Knobeloch,Shizuo Akira,Ari Waisman,Gunther Hartmann,Marco Prinz, NATURE NEUROSCIENCE, NATURE PUBLISHING GROUP, Vol. 15, No. 1, p. 98-U126, 2012/01
  • NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA, Sachin D. Deshmukh,Sabrina Mueller,Katrin Hese,Katharina S. Rauch,Julia Wennekamp,Osamu Takeuchi,Shizuo Akira,Douglas T. Golenbock,Philipp Henneke, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 188, No. 2, p. 774-780, 2012/01
  • The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice, Yuko Abe,Ken Fujii,Noriyo Nagata,Osamu Takeuchi,Shizuo Akira,Hiroyuki Oshiumi,Misako Matsumoto,Tsukasa Seya,Satoshi Koike, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 86, No. 1, p. 185-194, 2012/01
  • Essential roles of Tab2 and Tab3 1n the activation of MAPK, but not NF-kB, in B cells., Ori D,Kato H,Sanjo H,Akira S,Takeuchi O, 2012 Annual Meeting of Japanese Society for Immunology. No. 1-E 一W7-3-0/P, Kobe, December 5-7, 2012., 2012
  • Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice, Wataru Yoshioka,Keiko Aida-Yasuoka,Nozomi Fujisawa,Tatsuya Kawaguchi,Seiichiroh Ohsako,Shuntaro Hara,Satoshi Uematsu,Shizuo Akira,Chiharu Tohyama, Toxicological Sciences, Vol. 127, No. 2, p. 547-554, 2012
  • Contribution of LGP2 to Viral Recognition Pathways., Takeuchi O,Akira S, Nucleic Acid Sensors and Antiviral Immunity, Landes Bioscience, 2012., 2012
  • Stochastic binary modeling of cells in continuous time as an alternative to biochemical reaction equations, Shunsuke Teraguchi,Yutaro Kumagai,Alexis Vandenbon,Shizuo Akira,Daron M. Standley, PHYSICAL REVIEW E, AMER PHYSICAL SOC, Vol. 84, No. 6, 2011/12
  • Novel strategies to improve DNA vaccine immunogenicity, Cevayir Coban,Kouji Kobiyama,Taiki Aoshi,Fumihiko Takeshita,Toshihiro Horii,Shizuo Akira,Ken J. Ishii, Current Gene Therapy, Vol. 11, No. 6, p. 479-484, 2011/12
  • The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1, Hidenori Iwasaki,Osamu Takeuchi,Shunsuke Teraguchi,Kazufumi Matsushita,Takuya Uehata,Kanako Kuniyoshi,Takashi Satoh,Tatsuya Saitoh,Mutsuyoshi Matsushita,Daron M. Standley,Shizuo Akira, Nature Immunology, Vol. 12, No. 12, p. 1167-1175, 2011/12
  • MyD88 Plays an Essential Role in Inducing B Cells Capable of Differentiating into Antibody-Secreting Cells after Vaccination, Sang-Moo Kang,Dae-Goon Yoo,Min-Chul Kim,Jae-Min Song,Min-Kyung Park,O. Eunju,Fu-Shi Quan,Shizuo Akira,Richard W. Compans, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 85, No. 21, p. 11391-11400, 2011/11
  • Effect of Toll-like receptor 2 and 4 of corneal fibroblasts on cytokine expression with co-cultured antigen presenting cells, Hyuk Jin Choi,Mee Kum Kim,Jung Hwa Ko,Hyun Ju Lee,Hyun Jeong Jeong,Won Ryang Wee,Seung-Yong Seong,Shizuo Akira, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 56, No. 2, p. 265-271, 2011/11
  • Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription, Hideki Hayashi,Tomoko Kohno,Kiyoshi Yasui,Hiroyuki Murota,Tohru Kimura,Gordon S. Duncan,Tomoki Nakashima,Kazuo Yamamoto,Ichiro Katayama,Yuhua Ma,Koon Jiew Chua,Takashi Suematsu,Isao Shimokawa,Shizuo Akira,Yoshinao Kubo,Tak Wah Mak,Toshifumi Matsuyama, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 108, No. 46, p. 18766-18771, 2011/11
  • The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A, Ana Paula Moreira,Karen A. Cavassani,Ugur B. Ismailoglu,Rikki Hullinger,Michael P. Dunleavy,Darryl A. Knight,Steven L. Kunkel,Satoshi Uematsu,Shizuo Akira,Cory M. Hogaboam, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 121, No. 11, p. 4420-4432, 2011/11
  • The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling, Kristopher Clark,Osamu Takeuchi,Shizuo Akira,Philip Cohen, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 108, No. 41, p. 17093-17098, 2011/10
  • TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice, Hye Sung Kim,Heounjeong Go,Shizuo Akira,Doo Hyun Chung, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 187, No. 8, p. 4007-4017, 2011/10
  • Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane, Tolga T. Barker,Pui Y. Lee,Kindra M. Kelly-Scumpia,Jason S. Weinstein,Dina C. Nacionales,Yutaro Kumagai,Shizuo Akira,Byron P. Croker,Eric S. Sobel,Westley H. Reeves,Minoru Satoh, LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, Vol. 91, No. 10, p. 1540-1550, 2011/10
  • Mind Bomb Proteins in the Antiviral Arsenal, Yutaro Kumagai,Shizuo Akira, Immunity, Vol. 35, No. 3, p. 320-322, 2011/09/23
  • Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia, M. Neubert,D. A. Ridder,P. Bargiotas,S. Akira,M. Schwaninger, Cell Death and Differentiation, Vol. 18, No. 9, p. 1521-1530, 2011/09
  • Lipocalin 2 Plays an Immunomodulatory Role and Has Detrimental Effects after Spinal Cord Injury, Khizr I. Rathore,Jennifer L. Berard,Adriana Redensek,Sabrina Chierzi,Ruben Lopez-Vales,Manuela Santos,Shizuo Akira,Samuel David, JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, Vol. 31, No. 38, p. 13412-13419, 2011/09
  • Epigenetic control of macrophage polarization, Osamu Takeuch,Shizuo Akira, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Vol. 41, No. 9, p. 2490-2493, 2011/09
  • Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity, Takumi Kawasaki,Taro Kawai,Shizuo Akira, Immunological Reviews, Vol. 243, No. 1, p. 61-73, 2011/09
  • Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins, Taro Kawai,Shizuo Akira, EMBO Molecular Medicine, Vol. 3, No. 9, p. 513-527, 2011/09
  • [Role of PRRs in vaccine]., Kumagai Y,Akira S, Nihon rinsho. Japanese journal of clinical medicine, Vol. 69, No. 9, p. 1541-1546, 2011/09
  • Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin, Daniel M. Andrews,Melvyn T. Chow,Yuting Ma,Claire L. Cotterell,Sally V. Watt,Desiree A. Anthony,Shizuo Akira,Yoichiro Iwakura,Joseph A. Trapani,Laurence Zitvogel,Mark J. Smyth, IMMUNOLOGY AND CELL BIOLOGY, NATURE PUBLISHING GROUP, Vol. 89, No. 6, p. 739-746, 2011/08
  • B cells enhance early innate immune responses during bacterial sepsis, Kindra M. Kelly-Scumpia,Philip O. Scumpia,Jason S. Weinstein,Matthew J. Delano,Alex G. Cuenca,Dina C. Nacionales,James L. Wynn,Pui Y. Lee,Yutaro Kumagai,Philip A. Efron,Shizuo Akira,Clive Wasserfall,Mark A. Atkinson,Lyle L. Moldawer, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 208, No. 8, p. 1673-1682, 2011/08
  • DNA released from dying host cells mediates aluminum adjuvant activity, Thomas Marichal,Keiichi Ohata,Denis Bedoret,Claire Mesnil,Catherine Sabatel,Kouji Kobiyama,Pierre Lekeux,Cevayir Coban,Shizuo Akira,Ken J. Ishii,Fabrice Bureau,Christophe J. Desmet, Nature Medicine, Vol. 17, No. 8, p. 996-1002, 2011/08
  • ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18, Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda, Journal of Experimental Medicine, Vol. 208, No. 7, p. 1533-1546, 2011/07/04
  • Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking, Ryutaro Fukui,Shin-Ichiroh Saitoh,Atsuo Kanno,Masahiro Onji,Takuma Shibata,Akihiko Ito,Morikazu Onji,Mitsuru Matsumoto,Shizuo Akira,Nobuaki Yoshida,Kensuke Miyake, IMMUNITY, CELL PRESS, Vol. 35, No. 1, p. 69-81, 2011/07
  • Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice, Koichiro Matsumoto,Keiko Kan-o,Miyuki Eguchi-Tsuda,Satoru Fukuyama,Yukari Asai,Takafumi Matsumoto,Atsushi Moriwaki,Yuko Matsunaga,Hiroko Tsutsui,Taro Kawai,Osamu Takeuchi,Shizuo Akira,Hideo Yagita,Miyuki Azuma,Yoichi Nakanishi,Hiromasa Inoue, American Journal of Respiratory Cell and Molecular Biology, Vol. 45, No. 1, p. 31-39, 2011/07/01
  • The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella., Shun Kageyama,Hiroko Omori,Tatsuya Saitoh,Takefumi Sone,Jun-Lin Guan,Shizuo Akira,Fumio Imamoto,Takeshi Noda,Tamotsu Yoshimori, Molecular biology of the cell, 13, Vol. 22, No. 13, p. 2290-300, 2011/07/01
  • Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections, Yun-Gi Kim,Jong-Hwan Park,Thornik Reimer,Darren P. Baker,Taro Kawai,Himanshu Kumar,Shizuo Akira,Christiane Wobus,Gabriel Núñez, Cell Host and Microbe, Vol. 9, No. 6, p. 496-507, 2011/06/16
  • A new subset of CD103+CD8α+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity, Kosuke Fujimoto,Thangaraj Karuppuchamy,Naoki Takemura,Masaki Shimohigoshi,Tomohisa Machida,Yasunari Haseda,Taiki Aoshi,Ken J. Ishii,Shizuo Akira,Satoshi Uematsu, Journal of Immunology, Vol. 186, No. 11, p. 6287-6295, 2011/06/01
  • Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)., Sumihito Togi,Osamu Ikeda,Shinya Kamitani,Misa Nakasuji,Yuichi Sekine,Ryuta Muromoto,Asuka Nanbo,Kenji Oritani,Taro Kawai,Shizuo Akira,Tadashi Matsuda, The Journal of biological chemistry, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 286, No. 21, p. 19170-7, 2011/05/27
  • Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity, Taro Kawai,Shizuo Akira, Immunity, Vol. 34, No. 5, p. 637-650, 2011/05/27
  • Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway, Sophia Davidson,Gerard Kaiko,Zhixuan Loh,Amit Lalwani,Vivian Zhang,Kirsten Spann,Shen Yun Foo,Nicole Hansbro,Satoshi Uematsu,Shizuo Akira,Klaus I. Matthaei,Helene F. Rosenberg,Paul S. Foster,Simon Phipps, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, No. 10, p. 5938-5948, 2011/05
  • TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen, Shirdi E. Letran,Seung-Joo Lee,Shaikh M. Atif,Adriana Flores-Langarica,Satoshi Uematsu,Shizuo Akira,Adam F. Cunningham,Stephen J. McSorley, Journal of Immunology, Vol. 186, No. 9, p. 5406-5412, 2011/05/01
  • Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms, Etsushi Kuroda,Ken J. Ishii,Satoshi Uematsu,Keiichi Ohata,Cevayir Coban,Shizuo Akira,Kosuke Aritake,Yoshihiro Urade,Yasuo Morimoto, Immunity, Vol. 34, No. 4, p. 514-526, 2011/04/22
  • Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression, Akihisa Fukuda,Sam C. Wang,John P. Morris,Alexandra E. Folias,Angela Liou,Grace E. Kim,Shizuo Akira,Kenneth M. Boucher,Matthew A. Firpo,Sean J. Mulvihill,Matthias Hebrok, Cancer Cell, Vol. 19, No. 4, p. 441-455, 2011/04/12
  • Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway, Motoharu Awazawa,Kohjiro Ueki,Kazunori Inabe,Toshimasa Yamauchi,Naoto Kubota,Kazuma Kaneko,Masatoshi Kobayashi,Aya Iwane,Takayoshi Sasako,Yukiko Okazaki,Mitsuru Ohsugi,Iseki Takamoto,Satoshi Yamashita,Hiroshi Asahara,Shizuo Akira,Masato Kasuga,Takashi Kadowaki, Cell Metabolism, Vol. 13, No. 4, p. 401-412, 2011/04/06
  • Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with Mycobacterium tuberculosis Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist, In Duk Jung,Soo Kyung Jeong,Chang-Min Lee,Kyung Tae Noh,Deok Rim Heo,Yong Kyoo Shin,Cheol-Heui Yun,Won-Jung Koh,Shizuo Akira,Jake Whang,Hwa-Jung Kim,Won Sun Park,Sung Jae Shin,Yeong-Min Park, CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 71, No. 8, p. 2858-2870, 2011/04
  • Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer, Marina Lesina,Magdalena U. Kurkowski,Katharina Ludes,Stefan Rose-John,Matthias Treiber,Guenter Kloeppel,Akihiko Yoshimura,Wolfgang Reindl,Bence Sipos,Shizuo Akira,Roland M. Schmid,Hana Alguel, CANCER CELL, CELL PRESS, Vol. 19, No. 4, p. 456-469, 2011/04
  • Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice, Hendrik J. Nel,Emily Hams,Sean P. Saunders,Niamh E. Mangan,Philip Smith,Ann Atzberger,Richard A. Flavell,Shizuo Akira,Andrew N. McKenzie,Padraic G. Fallon, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, No. 8, p. 4631-4639, 2011/04
  • Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice, Masako Isono,Tatsunori Suzuki,Kanako Hosono,Izumi Hayashi,Hiroyuki Sakagami,Satoshi Uematsu,Shizuo Akira,Yves A. DeClerck,Hirotugu Okamoto,Masataka Majima, LIFE SCIENCES, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 88, No. 15-16, p. 693-700, 2011/04
  • Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition, Erin L. Lousberg,Kerrilyn R. Diener,Cara K. Fraser,Simon Phipps,Paul S. Foster,Weisan Chen,Satoshi Uematsu,Shizuo Akira,Sarah A. Robertson,Michael P. Brown,John D. Hayball, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 85, No. 7, p. 3385-3396, 2011/04
  • Antiviral protein viperin promotes toll-like receptor 7- and toll-like receptor 9-mediated type i interferon production in plasmacytoid dendritic cells, Tatsuya Saitoh,Takashi Satoh,Naoki Yamamoto,Satoshi Uematsu,Osamu Takeuchi,Taro Kawai,Shizuo Akira, Immunity, Vol. 34, No. 3, p. 352-363, 2011/03/25
  • Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-beta Signaling, Christelle Bourgeois,Olivia Majer,Ingrid E. Frohner,Iwona Lesiak-Markowicz,Kwang-Soo Hildering,Walter Glaser,Silvia Stockinger,Thomas Decker,Shizuo Akira,Mathias Mueller,Karl Kuchler, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, No. 5, p. 3104-3112, 2011/03
  • TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection, Mingjian Fei,Shikha Bhatia,Timothy B. Oriss,Manohar Yarlagadda,Anupriya Khare,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Beth A. Fallert Junecko,Todd A. Reinhart,Oded Foreman,Prabir Ray,Jay Kolls,Anuradha Ray, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 108, No. 13, p. 5360-5365, 2011/03
  • Roles of an inducible prostaglandin E synthase, mPGES-1 in host in enhancement of tumor-associated angiogenesis, Kamata H,Hosono K,Suzuki T,Ogawa Y,Kubo H,Katoh H,Ito Y,Uematsu S,Akira S,Watanabe M,Majima M, The Kitasato Medical Journal, Vol. 41, No. 1, p. 19-30, 2011/03
  • Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels, Takako Takemiya,Kiyoshi Matsumura,Hiroko Sugiura,Shin Yasuda,Satoshi Uematsu,Shizuo Akira,Kanato Yamagata, NEUROCHEMISTRY INTERNATIONAL, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 58, No. 4, p. 489-496, 2011/03
  • Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses., Yukinobu Nakagawa,Hyota Takamatsu,Tatsusada Okuno,Sujin Kang,Satoshi Nojima,Tetsuya Kimura,Tatsuki R Kataoka,Masahito Ikawa,Toshihiko Toyofuku,Ichiro Katayama,Atsushi Kumanogoh, Journal of immunology (Baltimore, Md. : 1950), Vol. 186, No. 5, p. 2881-8, 2011/03/01
  • Type I Interferon Signaling Regulates Ly6C(hi) Monocytes and Neutrophils during Acute Viral Pneumonia in Mice, Sang-Uk Seo,Hyung-Joon Kwon,Hyun-Jeong Ko,Young-Ho Byun,Baik Lin Seong,Satoshi Uematsu,Shizuo Akira,Mi-Na Kweon, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 7, No. 2, 2011/02
  • The C Proteins of Human Parainfluenza Virus Type 1 Limit Double-Stranded RNA Accumulation That Would Otherwise Trigger Activation of MDA5 and Protein Kinase R, Jim Boonyaratanakornkit,Emmalene Bartlett,Henrick Schomacker,Sonja Surman,Shizuo Akira,Yong-Soo Bae,Peter Collins,Brian Murphy,Alexander Schmidt, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 85, No. 4, p. 1495-1506, 2011/02
  • IL-1 alpha Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil, Pui Y. Lee,Yutaro Kumagai,Yuan Xu,Yi Li,Tolga Barker,Chao Liu,Eric S. Sobel,Osamu Takeuchi,Shizuo Akira,Minoru Satoh,Westley H. Reeves, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, No. 3, p. 1747-1754, 2011/02
  • Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice, Sang-Uk Seo,Hyung-Joon Kwon,Hyun-Jeong Ko,Young-Ho Byun,Baik Lin Seong,Satoshi Uematsu,Shizuo Akira,Mi-Na Kweon, PLoS Pathogens, Vol. 7, No. 2, 2011/02
  • The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model, Akiko Numao,Kanako Hosono,Tatsunori Suzuki,Izumi Hayashi,Satoshi Uematsu,Shizuo Akira,Yukiko Ogino,Hirohito Kawauchi,Nobuya Unno,Masataka Majima, BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, Vol. 65, No. 1, p. 77-84, 2011/02
  • NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections, Himanshu Kumar,Surya Pandey,Jian Zou,Yutaro Kumagai,Ken Takahashi,Shizuo Akira,Taro Kawai, Journal of Immunology, Vol. 186, No. 2, p. 994-1000, 2011/01/15
  • Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype, Shikha Bhatia,Mingjian Fei,Manohar Yarlagadda,Zengbiao Qi,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Nico van Rooijen,Gregory A. Gibson,Claudette M. St Croix,Anuradha Ray,Prabir Ray, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 1, 2011/01
  • Activation of Lipopolysaccharide-TLR4 Signaling Accelerates the Ototoxic Potential of Cisplatin in Mice, Gi-Su Oh,Hyung-Jin Kim,Jae-Hyuck Choi,AiHua Shen,Chang-Hoi Kim,Se-Jin Kim,Sae-Ron Shin,Seung-Heon Hong,Yunha Kim,Channy Park,Sung-Joong Lee,Shizuo Akira,Raekil Park,Hong-Seob So, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, No. 2, p. 1140-1150, 2011/01
  • MyD88-Dependent Signaling Protects against Anthrax Lethal Toxin-Induced Impairment of Intestinal Barrier Function, Shu Okugawa,Mahtab Moayeri,Michael A. Eckhaus,Devorah Crown,Sharmina Miller-Randolph,Shihui Liu,Shizuo Akira,Stephen H. Leppla, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 79, No. 1, p. 118-124, 2011/01
  • Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity, Ya-Jen Chang,Hye Young Kim,Lee A. Albacker,Hyun Hee Lee,Nicole Baumgarth,Shizuo Akira,Paul B. Savage,Shin Endo,Takashi Yamamura,Janneke Maaskant,Naoki Kitano,Abel Singh,Apoorva Bhatt,Gurdyal S. Besra,Peter van den Elzen,Ben Appelmelk,Richard W. Franck,Guangwu Chen,Rosemarie H. DeKruyff,Michio Shimamura,Petr Illarionov,Dale T. Umetsu, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 121, No. 1, p. 57-69, 2011/01
  • Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells, Mayumi Ueta,Taro Kawai,Norihiko Yokoi,Shizuo Akira,Shigeru Kinoshita, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 404, No. 1, p. 419-423, 2011/01
  • Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1, Sun Myung Joung,Zee-Yong Park,Shilpa Rani,Osamu Takeuchi,Shizuo Akira,Joo Young Lee, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, No. 1, p. 499-507, 2011/01
  • Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4(+) T Cells during Aspergillus fumigatus Antigen Exposure, Sara A. Paveglio,Jenna Allard,Samantha R. Foster Hodgkins,Jennifer L. Ather,Mieke Bevelander,Jana Mayette Campbell,Laurie A. Whittaker LeClair,Sean M. McCarthy,Albert van der Vliet,Benjamin T. Suratt,Jonathan E. Boyson,Satoshi Uematsu,Shizuo Akira,Matthew E. Poynter, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, AMER THORACIC SOC, Vol. 44, No. 1, p. 11-23, 2011/01
  • Pathogen recognition by the innate immune system, Himanshu Kumar,Taro Kawai,Shizuo Akira, International Reviews of Immunology, Vol. 30, No. 1, p. 16-34, 2011/01
  • TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity, Shirdi E. Letran,Seung-Joo Lee,Shaikh M. Atif,Satoshi Uematsu,Shizuo Akira,Stephen J. McSorley, European Journal of Immunology, Vol. 41, No. 1, p. 29-38, 2011/01
  • Crohn disease: A current perspective on genetics, autophagy and immunity, Thaddeus S. Stappenbeck,John D. Rioux,Atsushi Mizoguchi,Tatsuya Saitoh,Alan Huett,Arlette Darfeuille-Michaud,Tom Wileman,Noboru Mizushima,Simon Carding,Shizuo Akira,Miles Parkes,Ramnik J. Xavier, Autophagy, Taylor and Francis Inc., Vol. 7, No. 4, p. 355-374, 2011
  • Innate and adaptive immune responses to viral infection and vaccination, Taiki Aoshi,Shohei Koyama,Kouji Kobiyama,Shizuo Akira,Ken J Ishii, Current Opinion in Virology, Elsevier, Vol. 1, No. 4, p. 226-232, 2011
  • Role of MyD88 and Toll-Like Receptors 2 and 4 in the Sensing of Parachlamydia acanthamoebae, Thierry Roger,Nicola Casson,Antony Croxatto,Jose Manuel Entenza,Marc Pusztaszeri,Shizuo Akira,Marlies Knaup Reymond,Didier Le Roy,Thierry Calandra,Gilbert Greub, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 78, No. 12, p. 5195-5201, 2010/12
  • Role of Adrenomedullin in Lyme Disease, Meghan L. Marre,Courtney T. Darcy,Janeth Yinh,Shizuo Akira,Satoshi Uematsu,Allen C. Steere,Linden T. Hu, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 78, No. 12, p. 5307-5313, 2010/12
  • MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection, Sang-Uk Seo,Hyung-Joon Kwon,Joo-Hye Song,Young-Ho Byun,Baik Lin Seong,Taro Kawai,Shizuo Akira,Mi-Na Kweon, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 84, No. 24, p. 12713-12722, 2010/12
  • Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN-Beta Induction, Hiroyuki Oshiumi,Masanori Ikeda,Misako Matsumoto,Ayako Watanabe,Osamu Takeuchi,Shizuo Akira,Nobuyuki Kato,Kunitada Shimotohno,Tsukasa Seya, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 5, No. 12, 2010/12
  • Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice, Ralph Burkhardt,Sue-Anne Toh,William R. Lagor,Andrew Birkeland,Michael Levin,Xiaoyu Li,Megan Robblee,Victor D. Fedorov,Masahiro Yamamoto,Takashi Satoh,Shizuo Akira,Sekar Kathiresan,Jan L. Breslow,Daniel J. Rader, Journal of Clinical Investigation, Vol. 120, No. 12, p. 4410-4414, 2010/12/01
  • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia, K. Hyakkoku,J. Hamanaka,K. Tsuruma,M. Shimazawa,H. Tanaka,S. Uematsu,S. Akira,N. Inagaki,H. Nagai,H. Hara, Neuroscience, Vol. 171, No. 1, p. 258-267, 2010/11/24
  • The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA, Tetsuo Tsuchida,Jian Zou,Tatsuya Saitoh,Himanshu Kumar,Takayuki Abe,Yoshiharu Matsuura,Taro Kawai,Shizuo Akira, Immunity, Vol. 33, No. 5, p. 765-776, 2010/11/24
  • Toll-Like Receptor 9 Enhances Nephritogenic Immunity and Glomerular Leukocyte Recruitment, Exacerbating Experimental Crescentic Glomerulonephritis, Shaun A. Summers,Oliver M. Steinmetz,Joshua D. Ooi,Poh-yi Gan,Kim M. O&apos;Sullivan,Kumar Visvanathan,Shizuo Akira,A. Richard Kitching,Stephen R. Holdsworth, AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, Vol. 177, No. 5, p. 2234-2244, 2010/11
  • Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers, Takako Ae,Takashi Ohno,Youichiro Hattori,Tatsunori Suzuki,Kanako Hosono,Tsutomu Minamino,Takehito Sato,Satoshi Uematsu,Shizuo Akira,Wasaburo Koizumi,Masataka Majima, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Vol. 299, No. 5, p. G1139-G1146, 2010/11
  • Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes (Retracted article. See vol. 32, pg. E22, 2012), Yasuko Abe,Akio Kawakami,Mizuko Osaka,Satoshi Uematsu,Shizuo Akira,Kentaro Shimokado,Frank M. Sacks,Masayuki Yoshida, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 30, No. 11, p. 2242-U501, 2010/11
  • Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling, Shuhei Hashiguchi,Yuya Yamaguchi,Osamu Takeuchi,Shizuo Akira,Kazuhisa Sugimura, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 402, No. 1, p. 19-22, 2010/11
  • Negative regulators in toll-like receptor responses, Shizuo Akira,Tatsuya Saitoh,Kazufumi Matsushita,Osamu Takeuchi, Cornea, Vol. 29, No. SUPPL. 1, p. S13-9, 2010/11
  • Influenza A virus polymerase inhibits type I interferon induction by binding to interferon β promoter stimulator 1, Atsushi Iwai,Takuya Shiozaki,Taro Kawai,Shizuo Akira,Yoshihiro Kawaoka,Ayato Takada,Hiroshi Kida,Tadaaki Miyazakia, Journal of Biological Chemistry, Vol. 285, No. 42, p. 32064-32074, 2010/10/15
  • IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18, Tohru Miyake,Takashi Satoh,Hiroki Kato,Kazufumi Matsushita,Yutaro Kumagai,Alexis Vandenbon,Tohru Tani,Tatsushi Muta,Shizuo Akira,Osamu Takeuchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 41, p. 17680-17685, 2010/10/12
  • Induction of type I interferon by adenovirus-encoded small RNAs, Tomoko Yamaguchi,Kenji Kawabata,Emi Kouyama,Ken J. Ishii,Kazufumi Katayama,Takayuki Suzuki,Shinnosuke Kurachi,Fuminori Sakurai,Shizuo Akira,Hiroyuki Mizuguchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 40, p. 17286-17291, 2010/10/05
  • Pathways Regulating Cytosolic Phospholipase A(2) Activation and Eicosanoid Production in Macrophages by Candida albicans, Saritha Suram,Todd A. Gangelhoff,Philip R. Taylor,Marcela Rosas,Gordon D. Brown,Joseph V. Bonventre,Shizuo Akira,Satoshi Uematsu,David L. Williams,Robert C. Murphy,Christina C. Leslie, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 285, No. 40, p. 30676-30685, 2010/10
  • The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection, Takashi Satoh,Osamu Takeuchi,Alexis Vandenbon,Koubun Yasuda,Yoshiaki Tanaka,Yutaro Kumagai,Tohru Miyake,Kazufumi Matsushita,Toshihiko Okazaki,Tatsuya Saitoh,Kiri Honma,Toshifumi Matsuyama,Katsuyuki Yui,Tohru Tsujimura,Daron M. Standley,Kenji Nakanishi,Kenta Nakai,Shizuo Akira, Nature Immunology, Vol. 11, No. 10, p. 936-944, 2010/10
  • E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity, Koji Sayama,Masahiro Yamamoto,Yuji Shirakata,Yasushi Hanakawa,Satoshi Hirakawa,Xiuju Dai,Mikiko Tohyama,Sho Tokumaru,Myoung-Sook Shin,Hiroaki Sakurai,Shizuo Akira,Koji Hashimoto, Journal of Biological Chemistry, Vol. 285, No. 39, p. 30042-30049, 2010/09/24
  • Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L, Kohichi Matsunaga,Eiji Morita,Tatsuya Saitoh,Shizuo Akira,Nicholas T. Ktistakis,Tetsuro Izumi,Takeshi Noda,Tamotsu Yoshimori, Journal of Cell Biology, Rockefeller University Press, Vol. 190, No. 4, p. 511-521, 2010/08/23
  • c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair, Keigo Machida,Hidekazu Tsukamoto,Jian-Chang Liu,Yuan-Ping Han,Sugantha Govindarajan,Michael M. C. Lai,Shizuo Akira,Jing-Hsiung James Ou, Hepatology, Vol. 52, No. 2, p. 480-492, 2010/08
  • A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis, Desiree A. Anthony,Daniel M. Andrews,Melvyn Chow,Sally V. Watt,Colin House,Shizuo Akira,Phillip I. Bird,Joseph A. Trapani,Mark J. Smyth, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 185, No. 3, p. 1794-1803, 2010/08
  • Control of adipose tissue inflammation through TRB1, Anke Ostertag,Allan Jones,Adam J. Rose,Maria Liebert,Stefan Kleinsorg,Anja Reimann,Alexandros Vegiopoulos,Mauricio Berriel Diaz,Daniela Strzoda,Masahiro Yamamoto,Takashi Satoh,Shizuo Akira,Stephan Herzig, Diabetes, Vol. 59, No. 8, p. 1991-2000, 2010/08
  • The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells, Behnaz Shokouhi,Cevayir Coban,Vasif Hasirci,Erkin Aydin,Anandhan Dhanasingh,Nian Shi,Shohei Koyama,Shizuo Akira,Martin Zenke,Antonio S. Sechi, Biomaterials, Vol. 31, No. 22, p. 5759-5771, 2010/08
  • Systemic Toll-Like Receptor Stimulation Suppresses Experimental Allergic Asthma and Autoimmune Diabetes in NOD Mice, Aude Aumeunier,Francoise Grela,Abdulraouf Ramadan,Linh Pham Van,Emilie Bardel,Alejandro Gomez Alcala,Pascale Jeannin,Shizuo Akira,Jean-Francois Bach,Nathalie Thieblemont, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 5, No. 7, 2010/07
  • Telomere-Mediated Chromosomal Instability Triggers TLR4 Induced Inflammation and Death in Mice, Rabindra N. Bhattacharjee,Birendranath Banerjee,Shizuo Akira,M. Prakash Hande, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 5, No. 7, 2010/07
  • A novel in vivo inducible dendritic cell ablation model in mice., Okuyama M,Kayama H,Atarashi K,Saiga H,Kimura T,Waisman A,Yamamoto M,Takeda K, <i><b> Biochem Biophys Res Commun. </b></i>, Vol. 397, No. 3, p. 559-563, 2010/07
  • MPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice, Hiroki Kamata,Kanako Hosono,Tatsunori Suzuki,Yasufumi Ogawa,Hidefumi Kubo,Hiroshi Katoh,Yoshiya Ito,Satoshi Uematsu,Shizuo Akira,Masahiko Watanabe,Masataka Majima, Biomedicine and Pharmacotherapy, Vol. 64, No. 6, p. 409-416, 2010/07
  • TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine, Cevayir Coban,Toshihiro Horii,Shizuo Akira,Ken J Ishii, Expert Review of Vaccines, Vol. 9, No. 7, p. 775-784, 2010/07
  • Regulation of innate immune responses by autophagy-related proteins, Tatsuya Saitoh,Shizuo Akira, Journal of Cell Biology, Vol. 189, No. 6, p. 925-935, 2010/06/14
  • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release, Huan Yang,Hulda S. Hreggvidsdottir,Karin Palmblad,Haichao Wang,Mahendar Ochani,Jianhua Li,Ben Lu,Sangeeta Chavan,Mauricio Rosas-Ballina,Yousef Al-Abed,Shizuo Akira,Angelika Bierhaus,Helena Erlandsson-Harris,Ulf Andersson,Kevin J. Tracey, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 107, No. 26, p. 11942-11947, 2010/06
  • Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells, Zi-jian Pan,Shannon Maier,Karen Schwarz,Jennifer Azbill,Shizuo Akira,Satoshi Uematsu,A. Darise Farris, ANNALS OF THE RHEUMATIC DISEASES, B M J PUBLISHING GROUP, Vol. 69, No. 6, p. 1195-1199, 2010/06
  • Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice, Marie-Laure Santiago-Raber,Isabelle Dunand-Sauthier,Tianfu Wu,Quan-Zhen Li,Satoshi Uematsu,Shizuo Akira,Walter Reith,Chandra Mohan,Brian L. Kotzin,Shozo Izui, JOURNAL OF AUTOIMMUNITY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 34, No. 4, p. 339-348, 2010/06
  • Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans., Shinobu Saijo,Satoshi Ikeda,Keiko Yamabe,Shigeru Kakuta,Harumichi Ishigame,Aoi Akitsu,Noriyuki Fujikado,Toshimasa Kusaka,Sachiko Kubo,Soo-hyun Chung,Ryohei Komatsu,Noriko Miura,Yoshiyuki Adachi,Naohito Ohno,Kazutoshi Shibuya,Natsuo Yamamoto,Kazuyoshi Kawakami,Sho Yamasaki,Takashi Saito,Shizuo Akira,Yoichiro Iwakura, Immunity, Vol. 32, No. 5, p. 681-91, 2010/05/28
  • TAK1 Suppresses a NEMO-Dependent but NF-kappa B-Independent Pathway to Liver Cancer, Kira Bettermann,Mihael Vucur,Johannes Haybaeck,Christiane Koppe,Joern Janssen,Felix Heymann,Achim Weber,Ralf Weiskirchen,Christian Liedtke,Nikolaus Gassler,Michael Mueller,Rita de Vos,Monika Julia Wolf,Yannick Boege,Gitta Maria Seleznik,Nicolas Zeller,Daniel Erny,Thomas Fuchs,Stefan Zoller,Stefano Cairo,Marie-Annick Buendia,Marco Prinz,Shizuo Akira,Frank Tacke,Mathias Heikenwalder,Christian Trautwein,Tom Luedde, CANCER CELL, CELL PRESS, Vol. 17, No. 5, p. 481-496, 2010/05
  • Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis, Daniel J. Fong,Cory M. Hogaboam,Yosuke Matsuno,Shizuo Akira,Satoshi Uematsu,Amrita D. Joshi, IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 130, No. 1, p. 125-136, 2010/05
  • Human lactoferrin activates NF-kappa B through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling, Ken Ando,Keiichi Hasegawa,Ken-ichi Shindo,Tomoyasu Furusawa,Tomofumi Fujino,Kiyomi Kikugawa,Hiroyasu Nakano,Osamu Takeuchi,Shizuo Akira,Taishin Akiyama,Jin Gohda,Jun-ichiro Inoue,Makio Hayakawa, FEBS JOURNAL, WILEY-BLACKWELL, Vol. 277, No. 9, p. 2051-2066, 2010/05
  • Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity, Oliver Schulz,Andreas Pichlmair,Jan Rehwinkel,Neil C. Rogers,Donalyn Scheuner,Hiroki Kato,Osamu Takeuchi,Shizuo Akira,Randal J. Kaufman,Caetano Reis e Sousa, CELL HOST & MICROBE, CELL PRESS, Vol. 7, No. 5, p. 354-361, 2010/05
  • The role of pattern-recognition receptors in innate immunity: Update on toll-like receptors, Taro Kawai,Shizuo Akira, Nature Immunology, Vol. 11, No. 5, p. 373-384, 2010/05
  • Identification and functions of pattern-recognition receptors, Yutaro Kumagai,Shizuo Akira, Journal of Allergy and Clinical Immunology, Vol. 125, No. 5, p. 985-992, 2010/05
  • Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-κB signaling, Claudia Toma,Naomi Higa,Yukiko Koizumi,Noboru Nakasone,Yasunori Ogura,Andrea J. McCoy,Luigi Franchi,Satoshi Uematsu,Junji Sagara,Shun'ichiro Taniguchi,Hiroko Tsutsui,Shizuo Akira,Jürg Tschopp,Gabriel Núñez,Toshihiko Suzuki, Journal of Immunology, Vol. 184, No. 9, p. 5287-5297, 2010/05/01
  • IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors., Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H, Nature, Vol. 464, No. 7293, p. 1381-1385, 2010/04
  • Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes., Shohei Koyama,Taiki Aoshi,Takeshi Tanimoto,Yutaro Kumagai,Kouji Kobiyama,Takahiro Tougan,Kazuo Sakurai,Cevayir Coban,Toshihiro Horii,Shizuo Akira,Ken J Ishii, Science translational medicine, Vol. 2, No. 25, 2010/03/31
  • Microsomal prostaglandin e synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity, Y. Ikeda-Matsuo,Y. Hirayama,A. Ota,S. Uematsu,S. Akira,Y. Sasaki, British Journal of Pharmacology, Vol. 159, No. 5, p. 1174-1186, 2010/03
  • Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists, Deepa Rajagopal,Carine Paturel,Yannis Morel,Satoshi Uematsu,Shizuo Akira,Sandra S. Diebold, BLOOD, AMER SOC HEMATOLOGY, Vol. 115, No. 10, p. 1949-1957, 2010/03
  • Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling, Philip O. Scumpia,Kindra M. Kelly-Scumpia,Matthew J. Delano,Jason S. Weinstein,Alex G. Cuenca,Samer Al-Quran,Ian Bovio,Shizuo Akira,Yutaro Kumagai,Lyle L. Moldawer, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 184, No. 5, p. 2247-2251, 2010/03
  • Pattern Recognition Receptors and Inflammation, Osamu Takeuchi,Shizuo Akira, Cell, Vol. 140, No. 6, p. 805-820, 2010/03
  • Intracellular mycobacterium avium intersect transferrin in the Rab11 + recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway, Øyvind Halaas,Magnus Steigedal,Markus Haug,Jane A. Awuh,Liv Ryan,Andreas Brech,Shintaro Sato,Harald Husebye,Gerard A. Cangelosi,Shizuo Akira,Roland K. Strong,Terje Espevik,Trude H. Flo, Journal of Infectious Diseases, Vol. 201, No. 5, p. 783-792, 2010/03/01
  • Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome, Thornik Reimer,Michael H. Shaw,Luigi Franchi,Cevayir Coban,Ken J. Ishii,Shizuo Akira,Toshihiro Horii,Ana Rodriguez,Gabriel Núñez, European Journal of Immunology, Vol. 40, No. 3, p. 764-769, 2010/03
  • Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells, Christian A. Luber,Juergen Cox,Henning Lauterbach,Ben Fancke,Matthias Selbach,Jurg Tschopp,Shizuo Akira,Marian Wiegand,Hubertus Hochrein,Meredith O&apos;Keeffe,Matthias Mann, IMMUNITY, CELL PRESS, Vol. 32, No. 2, p. 279-289, 2010/02
  • Endothelial Microsomal Prostaglandin E Synthase-1 Exacerbates Neuronal Loss Induced by Kainate, Takako Takemiya,Kiyoshi Matsumura,Hiroko Sugiura,Michiyo Maehara,Shin Yasuda,Satoshi Uematsu,Shizuo Akira,Kanato Yamagata, JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, Vol. 88, No. 2, p. 381-390, 2010/02
  • TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection, Elia Burns,Tal Eliyahu,Satoshi Uematsu,Shizuo Akira,Gabriel Nussbaum, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 184, No. 3, p. 1455-1462, 2010/02
  • Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9, Cevayir Coban,Yoshikatsu Igari,Masanori Yagi,Thornik Reimer,Shohei Koyama,Taiki Aoshi,Keiichi Ohata,Toshihiro Tsukui,Fumihiko Takeshita,Kazuo Sakurai,Takahisa Ikegami,Atsushi Nakagawa,Toshihiro Horii,Gabriel Nuñez,Ken J. Ishii,Shizuo Akira, Cell Host and Microbe, Vol. 7, No. 1, p. 50-61, 2010/01/21
  • Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice, Tomokazu Matsuda,Yoshiaki Kido,Shun-Ichiro Asahara,Tsuneyasu Kaisho,Takashi Tanaka,Naoko Hashimoto,Yutaka Shigeyama,Akihiko Takeda,Tae Inoue,Yuki Shibutani,Maki Koyanagi,Tetsuya Hosooka,Michihiro Matsumoto,Hiroshi Inoue,Tohru Uchida,Masato Koike,Yasuo Uchiyama,Shizuo Akira,Masato Kasuga, Journal of Clinical Investigation, Vol. 120, No. 1, p. 115-126, 2010/01/04
  • Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice, Toru Hosoi,Shota Yokoyama,Suguru Matsuo,Shizuo Akira,Koichiro Ozawa, PLoS ONE, Vol. 5, No. 9, p. 1-7, 2010
  • Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway, Peter Broglie,Kunihiro Matsumoto,Shizuo Akira,David L. Brautigan,Jun Ninomiya-Tsuji, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 285, No. 4, p. 2333-2339, 2010/01
  • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production, Hendrik Poeck,Michael Bscheider,Olaf Gross,Katrin Finger,Susanne Roth,Manuele Rebsamen,Nicole Hannesschlaeger,Martin Schlee,Simon Rothenfusser,Winfried Barchet,Hiroki Kato,Shizuo Akira,Satoshi Inoue,Stefan Endres,Christian Peschel,Gunther Hartmann,Veit Hornung,Juergen Ruland, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 11, No. 1, p. 63-1824, 2010/01
  • Prostaglandin E-2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation, Anders Lundequist,Samridhi N. Nallamshetty,Wei Xing,Chunli Feng,Tanya M. Laidlaw,Satoshi Uematsu,Shizuo Akira,Joshua A. Boyce, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 184, No. 1, p. 433-441, 2010/01
  • Microsomal prostaglandin e synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors, Y. Ikeda-Matsuo,H. Tanji,A. Ota,Y. Hirayama,S. Uematsu,S. Akira,Y. Sasaki, British Journal of Pharmacology, John Wiley and Sons Inc., Vol. 160, No. 4, p. 847-859, 2010
  • Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway., Gang Xiao,Akiko Miyazato,Yuzuru Abe,Tiantuo Zhang,Kiwamu Nakamura,Ken Inden,Misuzu Tanaka,Daiki Tanno,Tomomitsu Miyasaka,Keiko Ishii,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Natsuo Yamamoto,Hiroyuki Kunishima,Yoichi Hirakata,Mitsuo Kaku,Kazuyoshi Kawakami, Cellular immunology, Vol. 263, No. 2, p. 241-50, 2010
  • Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis And Anagen Induction Shown By Using Keratinocyte-Specific TAK1-Deficient Mice, Koji Sayama,Kentaro Kajiya,Koji Sugawara,Shintaro Sato,Satoshi Hirakawa,Yuji Shirakata,Yasushi Hanakawa,Xiuju Dai,Yumiko Ishimatsu-Tsuji,Daniel Metzger,Pierre Chambon,Shizuo Akira,Ralf Paus,Jiro Kishimoto,Koji Hashimoto, PLoS ONE, Vol. 5, No. 6, 2010
  • Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis, Daisuke Kamei,Makoto Murakami,Yuka Sasaki,Yoshihito Nakatani,Masataka Majima,Yukio Ishikawa,Toshiharu Ishi,Satoshi Uematsu,Shizuo Akira,Shuntaro Hara,Ichiro Kudo, Biochemical Journal, Vol. 425, No. 2, p. 361-371, 2010
  • The malarial metabolite hemozoin and its potential use as a vaccine adjuvant, Cevayir Coban,Masanori Yagi,Keiichi Ohata,Yoshikatsu Igari,Toshihiro Tsukui,Toshihiro Horii,Ken J Ishii,Shizuo Akira, Allergology International, Japanese Society of Allergology, Vol. 59, No. 2, p. 115-124, 2010
  • An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence, Michael Berger,Philippe Krebs,Karine Crozat,Xiaohong Li,Ben A. Croker,Owen M. Siggs,Daniel Popkin,Xin Du,Brian R. Lawson,Argyrios N. Theofilopoulos,Yu Xia,Kevin Khovananth,Eva Marie Y. Moresco,Takashi Satoh,Osamu Takeuchi,Shizuo Akira,Bruce Beutler, Nature Immunology, Vol. 11, No. 4, p. 335-343, 2010
  • Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal β-glucan, Himanshu Kumar,Yutaro Kumagai,Tetsuo Tsuchida,Paul A. Koenig,Takashi Satoh,Zijin Guo,Myoung Ho Jang,Tatsuya Saitoh,Shizuo Akira,Taro Kawai, Journal of Immunology, Vol. 183, No. 12, p. 8061-8067, 2009/12/15
  • Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13, Xuefeng Wu,Masahiro Yamamoto,Shizuo Akira,Shao-Cong Sun, Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 49, p. 20836-20841, 2009/12/08
  • Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response, Tatsuya Saitoh,Naonobu Fujita,Takuya Hayashi,Keigo Takahara,Takashi Satoh,Hanna Lee,Kohichi Matsunaga,Shun Kageyama,Hiroko Omori,Takeshi Noda,Naoki Yamamoto,Taro Kawai,Ken Ishii,Osamu Takeuchi,Tamotsu Yoshimori,Shizuo Akira, Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 49, p. 20842-20846, 2009/12/08
  • Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78, Melanie L. Conrad,Ruth Ferstl,Rene Teich,Stephanie Brand,Nicole Bluemer,Ali Oe. Yildirim,Cecilia C. Patrascan,Anna Hanuszkiewicz,Shizuo Akira,Hermann Wagner,Otto Holst,Erika von Mutius,Petra I. Pfefferle,Carsten J. Kirschning,Holger Garn,Harald Renz, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 206, No. 13, p. 2869-2877, 2009/12
  • Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearance, Suzanne Talbot,Sabine Toetemeyer,Masahiro Yamamoto,Shizuo Akira,Katherine Hughes,David Gray,Tom Barr,Pietro Mastroeni,Duncan J. Maskell,Clare E. Bryant, IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 128, No. 4, p. 472-483, 2009/12
  • Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis, Yasuyuki Kihara,Takuya Matsushita,Yoshihiro Kita,Satoshi Uematsu,Shizuo Akira,Jun-ichi Kira,Satoshi Ishii,Takao Shimizu, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 106, No. 51, p. 21807-21812, 2009/12
  • Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle, Eri Ishikawa,Tetsuaki Ishikawa,Yasu S. Morita,Kenji Toyonaga,Hisakata Yamada,Osamu Takeuchi,Taroh Kinoshita,Shizuo Akira,Yasunobu Yoshikai,Sho Yamasaki, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 206, No. 13, p. 2879-2888, 2009/12
  • TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway, Yoshida Ryoko,Takaesu Giichi,Yoshida Hideyuki,Okamoto Fuyuki,Yoshioka Tomoko,Choi Yongwon,Akira Shizuo,Kawai Taro,Yoshimura Akihiko,Kobayashi Takashi, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 284, No. 52, 2009/12
  • Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts., Naonobu Fujita,Tatsuya Saitoh,Shun Kageyama,Shizuo Akira,Takeshi Noda,Tamotsu Yoshimori, The Journal of biological chemistry, 47, Vol. 284, No. 47, p. 32602-9, 2009/11/20
  • HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses, Hideyuki Yanai,Tatsuma Ban,ZhiChao Wang,Myoung Kwon Choi,Takeshi Kawamura,Hideo Negishi,Makoto Nakasato,Yan Lu,Sho Hangai,Ryuji Koshiba,David Savitsky,Lorenza Ronfani,Shizuo Akira,Marco E. Bianchi,Kenya Honda,Tomohiko Tamura,Tatsuhiko Kodama,Tadatsugu Taniguchi, NATURE, NATURE PUBLISHING GROUP, Vol. 462, No. 7269, p. 99-U110, 2009/11
  • Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation, Pui Y. Lee,Yi Li,Yutaro Kumagai,Yuan Xu,Jason S. Weinstein,Erinn S. Kellner,Dina G. Nacionales,Edward J. Butfiloski,Nico van Rooijen,Shizuo Akira,Eric S. Sobel,Minoru Satoh,Westley H. Reeves, AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, Vol. 175, No. 5, p. 2023-2033, 2009/11
  • [Regulation of allergy by innate immune system]., Kumagai Y,Akira S, Nihon rinsho. Japanese journal of clinical medicine, Vol. 67, No. 11, p. 2055-2061, 2009/11
  • Control of inflammatory responses by a novel RNase, Zc3h12a, Osamu Takeuchi,Kazufumi Matsushita,Shizuo Akira, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 54, No. 14, p. 1837-1841, 2009/11
  • Toll-like receptors and innate immunity, Himanshu Kumar,Taro Kawai,Shizuo Akira, Biochemical and Biophysical Research Communications, Vol. 388, No. 4, p. 621-625, 2009/10/30
  • The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection, Laura Papon,Alexandra Oteiza,Tadaatsu Imaizumi,Hiroki Kato,Emiliana Brocchi,T. Glen Lawson,Shizuo Akira,Nadir Mechti, Virology, Vol. 393, No. 2, p. 311-318, 2009/10/25
  • Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling, Kohsuke Yamazaki,Jin Gohda,Atsuhiro Kanayama,Yusei Miyamoto,Hiroaki Sakurai,Masahiro Yamamoto,Shizuo Akira,Hidetoshi Hayashi,Bing Su,Jun-Ichiro Inoue, Science Signaling, Vol. 2, No. 93, 2009/10/20
  • Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2, Manfred Nairz,Igor Theurl,Andrea Schroll,Milan Theurl,Gernot Fritsche,Ewald Lindner,Markus Seifert,Marie-Laure V. Crouch,Klaus Hantke,Shizuo Akira,Ferric C. Fang,Guenter Weiss, BLOOD, AMER SOC HEMATOLOGY, Vol. 114, No. 17, p. 3642-3651, 2009/10
  • Two Mechanistically and Temporally Distinct NF-kappa B Activation Pathways in IL-1 Signaling, Kohsuke Yamazaki,Jin Gohda,Atsuhiro Kanayama,Yusei Miyamoto,Hiroaki Sakurai,Masahiro Yamamoto,Shizuo Akira,Hidetoshi Hayashi,Bing Su,Jun-Ichiro Inoue, SCIENCE SIGNALING, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 2, No. 93, 2009/10
  • Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection, Andreas Pichlmair,Oliver Schulz,Choon-Ping Tan,Jan Rehwinkel,Hiroki Kato,Osamu Takeuchi,Shizuo Akira,Michael Way,Giampietro Schiavo,Caetano Reis e Sousa, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 83, No. 20, p. 10761-10769, 2009/10
  • A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA, Myoung Kwon Choi,ZhiChao Wang,Tatsuma Ban,Hideyuki Yanai,Yan Lu,Ryuji Koshiba,Yukana Nakaima,Sho Hangai,David Savitsky,Makoto Nakasato,Hideo Negishi,Osamu Takeuchi,Kenya Honda,Shizuo Akira,Tomohiko Tamura,Tadatsugu Taniguchi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 106, No. 42, p. 17870-17875, 2009/10
  • Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes, Kei Yasuda,Christophe Richez,Melissa B. Uccellini,Rocco J. Richards,Ramon G. Bonegio,Shizuo Akira,Marc Monestier,Ronald B. Corley,Gregory A. Viglianti,Ann Marshak-Rothstein,Ian R. Rifkin, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 183, No. 5, p. 3109-3117, 2009/09
  • Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity, Tomohiro Kubo,Yuki Uchida,Yuko Watanabe,Masahiro Abe,Akira Nakamura,Masao Ono,Shizuo Akira,Toshiyuki Takai, Journal of Experimental Medicine, Vol. 206, No. 9, p. 1971-1982, 2009/08/31
  • Poly I:C-induced activation of NK cells by CD8α<sup>+</sup> dendritic cells via the IPS-1 and TRIF-dependent pathways, Tohru Miyake,Yutaro Kumagai,Hiroki Kato,Zijin Guo,Kazufumi Matsushita,Takashi Satoh,Tatsukata Kawagoe,Himanshu Kumar,Myoung Ho Jang,Taro Kawai,Tohru Tani,Osamu Takeuchi,Shizuo Akira, Journal of Immunology, Vol. 183, No. 4, p. 2522-2528, 2009/08/15
  • Lipopolysaccharide Inhibition of Glucose Production Through the Toll-Like Receptor-4, Myeloid Differentiation Factor 88, and Nuclear Factor kappa B Pathway, Carl F. Raetzsch,Natasha L. Brooks,J. McKee Alderman,Kelli S. Moore,Peter A. Hosick,Simon Klebanov,Shizuo Akira,James E. Bear,Albert S. Baldwin,Nigel Mackman,Terry P. Combs, HEPATOLOGY, JOHN WILEY & SONS INC, Vol. 50, No. 2, p. 592-600, 2009/08
  • A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP, Sarah M. McWhirter,Roman Barbalat,Kathryn M. Monroe,Mary F. Fontana,Mamoru Hyodo,Nathalie T. Joncker,Ken J. Ishii,Shizuo Akira,Marco Colonna,Zhijian J. Chen,Katherine A. Fitzgerald,Yoshihiro Hayakawa,Russell E. Vance, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 206, No. 9, p. 1899-1911, 2009/08
  • Innate immune control of nucleic acid-based vaccine immunogenicity, Shohei Koyama,Cevayir Coban,Taiki Aoshi,Toshihiro Horii,Shizuo Akira,Ken J. Ishii, Expert Review of Vaccines, Vol. 8, No. 8, p. 1099-1107, 2009/08
  • Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner, Takayuki Abe,Yuuki Kaname,Xiaoyu Wen,Hideki Tani,Kohji Moriishi,Satoshi Uematsu,Osamu Takeuchi,Ken J. Ishii,Taro Kawai,Shizuo Akira,Yoshiharu Matsuura, Journal of Virology, Vol. 83, No. 15, p. 7629-7640, 2009/08
  • Polyl:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation, Inigo Tirapu,Benoit Giquel,Lena Alexopoulou,Satoshi Uematsu,Richard Flavell,Shizuo Akira,Sandra S. Diebold, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 21, No. 7, p. 871-879, 2009/07
  • Downstream Signals for MyD88-Mediated Phagocytosis of Borrelia burgdorferi Can Be Initiated by TRIF and Are Dependent on PI3K, Ok S. Shin,Lloyd S. Miller,Robert L. Modlin,Shizuo Akira,Satoshi Uematsu,Linden T. Hu, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 183, No. 1, p. 491-498, 2009/07
  • Recognition of 5 &apos; Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus, Martin Schlee,Andreas Roth,Veit Hornung,Cristina Amparo Hagmann,Vera Wimmenauer,Winfried Barchet,Christoph Coch,Markus Janke,Aleksandra Mihailovic,Greg Wardle,Stefan Juranek,Hiroki Kato,Taro Kawai,Hendrik Poeck,Katherine A. Fitzgerald,Osamu Takeuchi,Shizuo Akira,Thomas Tuschl,Eicke Latz,Janos Ludwig,Gunther Hartmann, IMMUNITY, CELL PRESS, Vol. 31, No. 1, p. 25-34, 2009/07
  • Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans., Akiko Miyazato,Kiwamu Nakamura,Natsuo Yamamoto,Héctor M Mora-Montes,Misuzu Tanaka,Yuzuru Abe,Daiki Tanno,Ken Inden,Xiao Gang,Keiko Ishii,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Kotaro Mitsutake,Neil A R Gow,Mitsuo Kaku,Kazuyoshi Kawakami, Infection and immunity, Vol. 77, No. 7, p. 3056-64, 2009/07
  • NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection., Hisako Kayama,Ritsuko Koga,Koji Atarashi,Megumi Okuyama,Taishi Kimura,Tak W Mak,Satoshi Uematsu,Shizuo Akira,Hiroshi Takayanagi,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda, PLoS pathogens, Vol. 5, No. 7, 2009/07
  • Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin, John T. Bates,Satoshi Uematsu,Shizuo Akira,Steven B. Mizel, Journal of Immunology, Vol. 182, No. 12, p. 7539-7547, 2009/06/15
  • Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus, Sybille Kenzel,Sandra Santos-Sierra,Sachin D. Deshmukh,Inga Moeller,Bilge Ergin,Katherine A. Fitzgerald,Egil Lien,Shizuo Akira,Douglas T. Golenbock,Philipp Henneke, Infection and Immunity, Vol. 77, No. 6, p. 2474-2481, 2009/06
  • Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells, Giuseppe Mancuso,Maria Gambuzza,Angelina Midiri,Carmelo Biondo,Salvatore Papasergi,Shizuo Akira,Giuseppe Teti,Concetta Beninati, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 10, No. 6, p. 587-U48, 2009/06
  • Differential Role for c-Rel and C/EBP beta/delta in TLR-Mediated Induction of Proinflammatory Cytokines, Yong-Chen Lu,Ira Kim,Elizabeth Lye,Fang Shen,Nobutaka Suzuki,Shinobu Suzuki,Steve Gerondakis,Shizuo Akira,Sarah L. Gaffen,Wen-Chen Yeh,Pamela S. Ohashi, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 182, No. 11, p. 7212-7221, 2009/06
  • iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice, Carl De Trez,Stefan Magez,Shizuo Akira,Bernhard Ryffel,Yves Carlier,Eric Muraille, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 5, No. 6, 2009/06
  • Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome, Julie Delaloye,Thierry Roger,Quynh-Giao Steiner-Tardivel,Didier Le Roy,Marlies Knaup Reymond,Shizuo Akira,Virginie Petrilli,Carmen E. Gomez,Beatriz Perdiguero,Juerg Tschopp,Giuseppe Pantaleo,Mariano Esteban,Thierry Calandra, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 5, No. 6, 2009/06
  • Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin, Laure Janot,Jean-Claude Sirard,Thomas Secher,Nicolas Noulin,Lizette Fick,Shizuo Akira,Satoshi Uematsu,Arnaud Didierlaurent,Tracy Hussell,Bernhard Ryffel,Francois Erard, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, Vol. 39, No. 6, p. 1587-1596, 2009/06
  • [Regulation of inflammation by autophagy]., Saitoh T,Naonobu F,Yoshimori T,Akira S, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 54, No. 8 Suppl, p. 1119-1124, 2009/06
  • Pathogen recognition in the innate immune response, Himanshu Kumar,Taro Kawai,Shizuo Akira, Biochemical Journal, Vol. 420, No. 1, p. 1-16, 2009/05/15
  • TRAF6 Establishes Innate Immune Responses by Activating NF-kappa B and IRF7 upon Sensing Cytosolic Viral RNA and DNA, Hiroyasu Konno,Takuya Yamamoto,Kohsuke Yamazaki,Jin Gohda,Taishin Akiyama,Kentaro Semba,Hideo Goto,Atsushi Kato,Toshiaki Yujiri,Takahiko Imai,Yasushi Kawaguchi,Bing Su,Osamu Takeuchi,Shizuo Akira,Yasuko Tsunetsugu-Yokota,Jun-ichiro Inoue, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 4, No. 5, 2009/05
  • Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis, Mayumi Ueta,Satoshi Uematsu,Shizuo Akira,Shigeru Kinoshita, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 123, No. 5, p. 1187-1189, 2009/05
  • Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif, Julia Lichtnekert,Volker Vielhauer,Daniel Zecher,Onkar P. Kulkarni,Sebastian Clauss,Stephan Segerer,Veit Hornung,Tanya N. Mayadas,Bruce Beutler,Shizuo Akira,Hans-Joachim Anders, American Journal of Physiology - Renal Physiology, Vol. 296, No. 4, p. F867-F874, 2009/04
  • Ncf1 Provides a Reactive Oxygen Species-Independent Negative Feedback Regulation of TLR9-Induced IL-12p70 in Murine Dendritic Cells, Cornelia Richter,Martina Herrero San Juan,Jutta Will,Ralf P. Brandes,Ulrich Kalinke,Shizuo Akira,Josef M. Pfeilsehifter,Malin Hultqvist,Rikard Holmdahl,Heinfried H. Radeke, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 182, No. 7, p. 4183-4191, 2009/04
  • Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production, Yumiko Tsukamoto,Yoshinori Nagai,Ai Kariyone,Takuma Shibata,Tsuneyasu Kaisho,Shizuo Akira,Kensuke Miyake,Kiyoshi Takatsua, MOLECULAR IMMUNOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 46, No. 7, p. 1278-1288, 2009/04
  • Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif, Julia Lichtnekert,Volker Vielhauer,Daniel Zecher,Onkar P. Kulkarni,Sebastian Clauss,Stephan Segerer,Veit Hornung,Tanya N. Mayadas,Bruce Beutler,Shizuo Akira,Hans-Joachim Anders, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Vol. 296, No. 4, p. F867-F874, 2009/04
  • Toll-Like Receptor 2 Deficiency Is Associated with Enhanced Severity of Group B Streptococcal Disease, Manuela Puliti,Satoshi Uematsu,Shizuo Akira,Francesco Bistoni,Luciana Tissi, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 77, No. 4, p. 1524-1531, 2009/04
  • Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis, Eyal Amiel,Anselmo Alonso,Satoshi Uematsu,Shizuo Akira,Matthew E. Poynter,Brent Berwin, JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, Vol. 85, No. 4, p. 595-605, 2009/04
  • Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay, Kazufumi Matsushita,Osamu Takeuchi,Daron M. Standley,Yutaro Kumagai,Tatsukata Kawagoe,Tohru Miyake,Takashi Satoh,Hiroki Kato,Tohru Tsujimura,Haruki Nakamura,Shizuo Akira, Nature, Vol. 458, No. 7242, p. 1185-1190, 2009/04
  • Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-α production in plasmacytoid dendritic cells, Yutaro Kumagai,Himanshu Kumar,Shohei Koyama,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Journal of Immunology, Vol. 182, No. 7, p. 3960-3964, 2009/04
  • Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages, Masa Tsuchiya,Vincent Piras,Sangdun Choi,Shizuo Akira,Masaru Tomita,Alessandro Giuliani,Kumar Selvarajoo, PLoS ONE, Vol. 4, No. 3, 2009/03/20
  • TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and-independent humoral immune responses, Takashi Kobayashi,Tae Soo Kim,Anand Jacob,Matthew C. Walsh,Yuho Kadono,Ezequiel Fuentes-Pananá,Tomoko Yoshioka,Akihiko Yoshimura,Masahiro Yamamoto,Tsuneyasu Kaisho,Shizuo Akira,John G. Monroe,Yongwon Choi, PLoS ONE, Vol. 4, No. 3, 2009/03/09
  • ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO, Marieke A. D. van Zoelen,Huan Yang,Sandrine Florquin,Joost C. M. Meijers,Shizuo Akira,Bernd Arnold,Peter P. Nawroth,Angelika Bierhaus,Kevin J. Tracey,Tom van der Poll, SHOCK, LIPPINCOTT WILLIAMS & WILKINS, Vol. 31, No. 3, p. 280-284, 2009/03
  • Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products, Jenna B. Allard,Lisa Rinaldi,Matthew J. Wargo,Gilman Allen,Shizuo Akira,Satoshi Uematsu,Matthew E. Poynter,Deborah A. Hogan,Mercedes Rincon,Laurie A. Whittaker, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, Vol. 39, No. 3, p. 776-788, 2009/03
  • The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2, Kenji Kurokawa,Hanna Lee,Kyung-Baeg Roh,Miwako Asanuma,Young Sook Kim,Hiroshi Nakayama,Akiko Shiratsuchi,Youngnim Choi,Osamu Takeuchi,Hee Jung Kang,Naoshi Dohmae,Yoshinobu Nakanishi,Shizuo Akira,Kazuhisa Sekimizu,Bok Luel Lee, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 284, No. 13, p. 8406-8411, 2009/03
  • [Role of TLR-dependent and independent pathways in autoimmunity]., Kumagai Y,Akira S, Nihon rinsho. Japanese journal of clinical medicine, Vol. 67, No. 3, p. 487-493, 2009/03
  • C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia, Sho Yamasaki,Makoto Matsumoto,Osamu Takeuchi,Tetsuhiro Matsuzawa,Eri Ishikawa,Machie Sakuma,Hiroaki Tateno,Jun Uno,Jun Hirabayashi,Yuzuru Mikami,Kiyoshi Takeda,Shizuo Akira,Takashi Saito, Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 6, p. 1897-1902, 2009/02/10
  • Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4, Thierry Roger,Celine Froidevaux,Didier Le Roy,Marlies Knaup Reymond,Anne-Laure Chanson,Davide Mauri,Kim Burns,Beat Michel Riederer,Shizuo Akira,Thierry Calandra, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 106, No. 7, p. 2348-2352, 2009/02
  • Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-beta Signaling Pathway, Ju-Hyun Kim,Seon-Ju Kim,Im-Soon Lee,Myung-Shik Lee,Satoshi Uematsu,Shizuo Akira,Kwon Ik Oh, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 182, No. 4, p. 2458-2466, 2009/02
  • Involvement of linear polyubiquitylation of NEMO in NF-kappa B activation, Fuminori Tokunaga,Shin-ichi Sakata,Yasushi Saeki,Yoshinori Satomi,Takayoshi Kirisako,Kiyoko Kamei,Tomoko Nakagawa,Michiko Kato,Shigeo Murata,Shoji Yamaoka,Masahiro Yamamoto,Shizuo Akira,Toshifumi Takao,Keiji Tanaka,Kazuhiro Iwai, NATURE CELL BIOLOGY, NATURE PUBLISHING GROUP, Vol. 11, No. 2, p. 123-U40, 2009/02
  • A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant, Kouji Kobiyama,Fumihiko Takeshita,Ken J. Ishii,Shohei Koyama,Taiki Aoshi,Shizuo Akira,Asako Sakaue-Sawano,Atsushi Miyawaki,Yuko Yamanaka,Hisashi Hirano,Koichi Suzuki,Kenji Okuda, Journal of Immunology, American Association of Immunologists, Vol. 182, No. 3, p. 1593-1601, 2009/02/01
  • Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase, Li Li,Tetsuji Tanaka,Kazunori Yukawa,Shizuo Akira,Naohiko Umesaki, International Journal of Oncology, Vol. 34, No. 4, p. 905-914, 2009
  • Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?, Hua Huang,Shizuo Akira,Manuela M. Santos, Hepatology, Vol. 49, No. 3, p. 1012-1016, 2009
  • The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation, Sanae Haga,Michitaka Ozaki,Hiroshi Inoue,Yasuo Okamoto,Wataru Ogawa,Kiyoshi Takeda,Shizuo Akira,Satoru Todo, Hepatology, Vol. 49, No. 1, p. 204-214, 2009
  • The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice, Yana Filipovich,Shi-Jiang Lu,Shizuo Akira,Emmet Hirsch, AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, MOSBY-ELSEVIER, Vol. 200, No. 1, 2009/01
  • INHIBITION OF INTERLEUKIN-10 SIGNALING IN LUNG DENDRITIC CELLS BY TOLL-LIKE RECEPTOR 4 LIGANDS, Purnima Jose,Margarita G. Avdiushko,Shizuo Akira,Alan M. Kaplan,Donald A. Cohen, EXPERIMENTAL LUNG RESEARCH, TAYLOR & FRANCIS INC, Vol. 35, No. 1, p. 1-28, 2009
  • TLR4 Ligands Induce IFN-alpha Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-beta Priming, Christophe Richez,Kei Yasuda,Amanda A. Watkins,Shizuo Akira,Robert Lafyatis,Jean M. van Seventer,Ian R. Rifkin, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 182, No. 2, p. 820-828, 2009/01
  • Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene-like receptors, which synergize to induce type I interferon production, Simon B. Rasmussen,Soren B. Jensen,Christoffer Nielsen,Emanuel Quartin,Hiroki Kato,Zhijian J. Chen,Robert H. Silverman,Shizuo Akira,Soren R. Paludan, JOURNAL OF GENERAL VIROLOGY, MICROBIOLOGY SOC, Vol. 90, p. 74-78, 2009/01
  • Innate immunity to virus infection, Osamu Takeuchi,Shizuo Akira, IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, Vol. 227, No. 1, p. 75-86, 2009/01
  • Lipid a receptor TLR4-mediated signaling pathways, Shizuo Akira,Masahiro Yamamoto, Advances in Experimental Medicine and Biology, Vol. 667, p. 59-68, 2009
  • Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins, Tetsuo Tsuchida,Taro Kawai,Shizuo Akira, Cell Research, Vol. 19, No. 1, p. 3-4, 2009/01
  • The roles of TLRs, RLRs and NLRs in pathogen recognition, Taro Kawai,Shizuo Akira, International Immunology, Vol. 21, No. 4, p. 317-337, 2009
  • Induction of adaptive immunity by flagellin does not require robust activation of innate immunity, Catherine J. Sanders,Luigi Franchi,Felix Yarovinsky,Satoshi Uematsu,Shizuo Akira,Gabriel Núñez,Andrew T. Gewirtz, European Journal of Immunology, Vol. 39, No. 2, p. 359-371, 2009
  • Immune responses of TLR5+ lamina propria dendritic cells in enterobacterial infection, Satoshi Uematsu,Shizuo Akira, Journal of Gastroenterology, Vol. 44, No. 8, p. 803-811, 2009
  • Immune interventions of human diseases through toll-like receptors, Cevayir Cohan,Ken J. Ishii,Shizuo Akira, Advances in Experimental Medicine and Biology, Vol. 655, p. 63-80, 2009
  • Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages, Kohichi Matsunaga,Tatsuya Saitoh,Keisuke Tabata,Hiroko Omori,Takashi Satoh,Naoki Kurotori,Ikuko Maejima,Kanae Shirahama-Noda,Tohru Ichimura,Toshiaki Isobe,Shizuo Akira,Takeshi Noda,Tamotsu Yoshimori, Nature Cell Biology, 4, Vol. 11, No. 4, p. 385-396, 2009
  • Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium, Hiroyuki Saiga,Junichi Nishimura,Hirotaka Kuwata,Megumi Okuyama,Sohkichi Matsumoto,Shintaro Sato,Makoto Matsumoto,Shizuo Akira,Yasunobu Yoshikai,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda, Journal of Immunology, American Association of Immunologists, Vol. 181, No. 12, p. 8521-8527, 2008/12/15
  • CCAAT/enhancer-binding protein β promotes osteoblast differentiation by enhancing Runx2 activity with ATF4, Hiroyuki Tominaga,Shingo Maeda,Makoto Hayashi,Shu Takeda,Shizuo Akira,Setsuro Komiya,Takashi Nakamura,Haruhiko Akiyama,Takeshi Imamura, Molecular Biology of the Cell, Vol. 19, No. 12, p. 5373-5386, 2008/12
  • Viral 5 &apos;-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses, Ramanjaneyulu Allam,Rahul D. Pawar,Onkar P. Kulkarni,Veit Hornung,Gunter Hartman,Stephan Segerer,Shizuo Akira,Stefan Endres,Hans-Joachim Anders, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 38, No. 12, p. 3487-3498, 2008/12
  • Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation, Stephanie D. Lewis,Niranjan B. Butchi,Mohammed Khaleduzzaman,Tim W. Morgan,Min Du,Susan Pourciau,David G. Baker,Shizuo Akira,Karin E. Peterson, JOURNAL OF NEUROVIROLOGY, TAYLOR & FRANCIS INC, Vol. 14, No. 6, p. 492-502, 2008/12
  • RIG-I-like antiviral protein in flies, Osamu Takeuchi,Shizuo Akira, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 9, No. 12, p. 1327-1328, 2008/12
  • TLR7-dependent and Fc gamma R-independent production of type I interferon in experimental mouse lupus, Pui Y. Lee,Yutaro Kumagai,Yi Li,Osamu Takeuchi,Hideo Yoshida,Jason Weinstein,Erinn S. Kellner,Dina Nacionales,Tolga Barker,Kindra Kelly-Scumpia,Nico van Rooijen,Himanshu Kumar,Taro Kawai,Minoru Satoh,Shizuo Akira,Westley H. Reeves, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 205, No. 13, p. 2995-3006, 2008/12
  • Toll-Like Receptor 2 Mediates Apolipoprotein CIII-Induced Monocyte Activation, Akio Kawakami,Mizuko Osaka,Masanori Aikawa,Satoshi Uematsu,Shizuo Akira,Peter Libby,Kentaro Shimokado,Frank M. Sacks,Masayuki Yoshida, CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, Vol. 103, No. 12, p. 1402-U132, 2008/12
  • TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway, Ryoko Yoshida,Giichi Takaesu,Hideyuki Yoshida,Fuyuki Okamoto,Tomoko Yoshioka,Yongwon Choi,Shizuo Akira,Taro Kawai,Akihiko Yoshimura,Takashi Kobayashi, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 52, p. 36211-36220, 2008/12
  • [Autophagy and innate immunity]., Saitoh T,Fujita N,Yoshimori T,Akira S, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 53, No. 16 Suppl, p. 2279-2285, 2008/12
  • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production, Tatsuya Saitoh,Naonobu Fujita,Myoung Ho Jang,Satoshi Uematsu,Bo Gie Yang,Takashi Satoh,Hiroko Omori,Takeshi Noda,Naoki Yamamoto,Masaaki Komatsu,Keiji Tanaka,Taro Kawai,Tohru Tsujimura,Osamu Takeuchi,Tamotsu Yoshimori,Shizuo Akira, Nature, Vol. 456, No. 7219, p. 264-268, 2008/11/13
  • 5 &apos;-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma, Hendrik Poeck,Robert Besch,Cornelius Maihoefer,Marcel Renn,Damia Tormo,Svetlana Shulga Morskaya,Susanne Kirschnek,Evelyn Gaffal,Jennifer Landsberg,Johannes Hellmuth,Andreas Schmidt,David Anz,Michael Bscheider,Tobias Schwerd,Carola Berking,Carole Bourquin,Ulrich Kalinke,Elisabeth Kremmer,Hiroki Kato,Shizuo Akira,Rachel Meyers,Georg Haecker,Michael Neuenhahn,Dirk Busch,Juergen Ruland,Simon Rothenfusser,Marco Prinz,Veit Hornung,Stefan Endres,Thomas Tueting,Gunther Hartmann, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 14, No. 11, p. 1256-1263, 2008/11
  • Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits XFN-alpha responses by pDC, Zoe Waibler,Martina Anzaghe,Abdo Konur,Shizuo Akira,Werner Mueller,Ulrich Kalinke, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 38, No. 11, p. 3127-3137, 2008/11
  • Signaling flux redistribution at toll-like receptor pathway junctions, Kumar Selvarajoo,Yasunari Takada,Jin Gohda,Mohamed Helmy,Shizuo Akira,Masaru Tomita,Masa Tsuchiya,Jun-Ichiro Inoue,Koichi Matsuo, PLoS ONE, Vol. 3, No. 10, 2008/10/17
  • Targeted disruption of Hsp110/105 gene protects against ischemic stress, Junji Nakamura,Motoaki Fujimoto,Kunihiko Yasuda,Kiyoshi Takeda,Shizuo Akira,Takumi Hatayama,Yasushi Takagi,Kazuhiko Nozaki,Nobuko Hosokawa,Kazuhiro Nagata, Stroke, Vol. 39, No. 10, p. 2853-2859, 2008/10/01
  • TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection, Patricia A. Taylor,Michael J. Ehrhardt,Christopher J. Lees,Angela Panoskaltsis-Mortari,Arthur M. Krieg,Arlene H. Sharpe,William J. Murphy,Jonathan S. Serody,Hiroaki Hemmi,Shizuo Akira,Robert B. Levy,Bruce R. Blazar, BLOOD, AMER SOC HEMATOLOGY, Vol. 112, No. 8, p. 3508-3516, 2008/10
  • Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly, Michael S. Y. Huen,Jun Huang,Jingsong Yuan,Masahiro Yamamoto,Shizuo Akira,Carolyn Ashley,Wei Xiao,Junjie Chen, MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, Vol. 28, No. 19, p. 6104-6112, 2008/10
  • Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines, Qing Zhu,Colt Egelston,Aravindhan Vivekanandhan,Satoshi Uematsu,Shizuo Akira,Dennis M. Klinman,Igor M. Belyakov,Jay A. Berzofsky, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 105, No. 42, p. 16260-16265, 2008/10
  • Potential link between the immune system and metabolism of nucleic acids, Ken J Ishii,Shizuo Akira, Current Opinion in Immunology, Vol. 20, No. 5, p. 524-529, 2008/10
  • IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions, Takumi Koga,Hiroko Endo,Yasuhiro Miyamoto,Mutsuko Mukai,Shizuo Akira,Masahiro Inoue, Cancer Letters, Vol. 268, No. 1, p. 82-88, 2008/09/08
  • Innate immune response to viral infection, Shohei Koyama,Ken J. Ishii,Cevayir Coban,Shizuo Akira, Cytokine, Vol. 43, No. 3, p. 336-341, 2008/09
  • Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei, Kiwamu Nakamura,Akiko Miyazato,Yoshinobu Koguchi,Yoshiyuki Adachi,Naohito Ohno,Shinobu Saijo,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Jiro Fujita,Keiko Ishii,Mitsuo Kaku,Kazuyoshi Kawakami, MICROBES AND INFECTION, ELSEVIER SCIENCE BV, Vol. 10, No. 10-11, p. 1223-1227, 2008/08
  • Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S-enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88, Gemma L. Foster,Tom A. Barr,Andrew J. Grant,Trevelyan J. McKinley,Clare E. Bryant,Andrew MacDonald,David Gray,Masahiro Yamamoto,Shizuo Akira,Duncan J. Maskell,Pietro Mastroeni, IMMUNOLOGY, WILEY-BLACKWELL, Vol. 124, No. 4, p. 469-479, 2008/08
  • Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IκBζ-/- mice, Mayumi Ueta,Junji Hamuro,Eiichiro Ueda,Norito Katoh,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Shigeru Kinoshita, Investigative Ophthalmology and Visual Science, Vol. 49, No. 8, p. 3387-3394, 2008/08
  • Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APCMin/+ mice, N. Elander,J. Ungerbäck,H. Olsson,S. Uematsu,S. Akira,P. Söderkvist, Biochemical and Biophysical Research Communications, Vol. 372, No. 1, p. 249-253, 2008/07/18
  • Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis, Lijie Gong,Fayi Yao,Kristin Hockman,Henry H. Heng,Gregory J. Morton,Kiyoshi Takeda,Shizuo Akira,Malcolm J. Low,Marcelo Rubinstein,Robert G. MacKenzie, Endocrinology, Vol. 149, No. 7, p. 3346-3354, 2008/07
  • STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury, Julia E. Herrmann,Tetsuya Imura,Bingbing Song,Jingwei Qi,Yan Ao,Thu K. Nguyen,Rose A. Korsak,Kiyoshi Takeda,Shizuo Akira,Michael V. Sofroniew, JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, Vol. 28, No. 28, p. 7231-7243, 2008/07
  • Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice, Toshihiko Kobayashi,Koichiro Takahashi,Yoshinori Nagai,Takuma Shibata,Masako Otani,Shozo Izui,Shizuo Akira,Yoshiyuki Gotoh,Hiroshi Kiyono,Kensuke Miyake, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 20, No. 7, p. 881-891, 2008/07
  • TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice, Minghui Tang,Xudong Wei,Yinshi Guo,Peter Breslin,Shubin Zhang,Shanshan Zhang,Wei Wei,Zhenbiao Xia,Manuel Diaz,Shizuo Akira,Jiwang Zhang, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 205, No. 7, p. 1611-1619, 2008/07
  • Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9, Nina Gratz,Maria Siller,Barbara Schaljo,Zaid A. Pirzada,Irene Gattermeier,Ivo Vojtek,Carsten J. Kirschning,Hermann Wagner,Emmanuelle Charpentier,Pavel Kovarik,Shizuo Akira, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 29, p. 19879-19887, 2008/07
  • Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis, Rie Kajino-Sakamoto,Maiko Inagaki,Elisabeth Lippert,Shizuo Akira,Sylvie Robine,Kunihiro Matsumoto,Christian Jobin,Jun Ninomiya-Tsuji, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 181, No. 2, p. 1143-1152, 2008/07
  • Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus, Marie-Laure Santiago-Raber,Shuichi Kikuchi,Paula Borel,Satoshi Uematsu,Shizuo Akira,Brian L. Kotzin,Shozo Izui, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 181, No. 2, p. 1556-1562, 2008/07
  • Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury, Koichi Obata,Hirokazu Katsura,Kan Miyoshi,Takashi Kondo,Hiroki Yamanaka,Kimiko Kobayashi,Yi Dai,Tetsuo Fukuoka,Shizuo Akira,Koichi Noguchi, Journal of Neurochemistry, Vol. 105, No. 6, p. 2249-2259, 2008/06
  • Distinct roles for MyD88 and toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction, Ok S. Shin,Ralph R. Isberg,Shizuo Akira,Satoshi Uematsu,Aruna K. Behera,Linden T. Hu, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 76, No. 6, p. 2341-2351, 2008/06
  • Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2, Tatsukata Kawagoe,Shintaro Sato,Kazufumi Matsushita,Hiroki Kato,Kosuke Matsui,Yutaro Kumagai,Tatsuya Saitoh,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 9, No. 6, p. 684-691, 2008/06
  • Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection, Christofer Samuelsson,Juergen Hausmann,Henning Lauterbach,Michaela Schmidt,Shizuo Akira,Hermann Wagner,Paul Chaplin,Mark Suter,Meredith O'Keeffe,Hubertus Hochrein, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 118, No. 5, p. 1776-1784, 2008/05
  • Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection, Nicolas Zucchini,Gilles Bessou,Stephanie Traub,Scott H. Robbins,Satoshi Uematsu,Shizuo Akira,Lena Alexopoulou,Marc Dalod, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 180, No. 9, p. 5799-5803, 2008/05
  • TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity, Binzhi Zhang,Ganesan Ramesh,Satoshi Uematsu,Shizuo Akira,W. Brian Reeves, Journal of the American Society of Nephrology, Vol. 19, No. 5, p. 923-932, 2008/05
  • MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis, Takayuki Tomita,Takanori Kanai,Toshimitsu Fujii,Yasuhiro Nemoto,Ryuichi Okamoto,Kiichiro Tsuchiya,Teruji Totsuka,Naoya Sakamoto,Shizuo Akira,Mamoru Watanabe, Journal of Immunology, American Association of Immunologists, Vol. 180, No. 8, p. 5291-5299, 2008/04/15
  • Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury, Yumiko Imai,Keiji Kuba,G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria Ermolaeva,Ruud Veldhuizen,Y. H. Connie Leung,Hongliang Wang,Haolin Liu,Yang Sun,Manolis Pasparakis,Manfred Kopf,Christin Mech,Sina Bavari,J. S. Malik Peiris,Arthur S. Slutsky,Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John Nicholls,Chengyu Jiang,Christoph J. Binder,Josef M. Penninger, CELL, CELL PRESS, Vol. 133, No. 2, p. 235-249, 2008/04
  • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta, Jonathan C. Kagan,Tian Su,Tiffany Horng,Amy Chow,Shizuo Akira,Ruslan Medzhitov, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 9, No. 4, p. 361-368, 2008/04
  • Requirement of toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis, Emina Savarese,Christian Steinberg,Rahul D. Pawar,Wolfgang Reindl,Shizuo Akira,Hans-Joachim Anders,Anne Krug, ARTHRITIS AND RHEUMATISM, WILEY-LISS, Vol. 58, No. 4, p. 1107-1115, 2008/04
  • Pathogen recognition by innate receptors, Yutaro Kumagai,Osamu Takeuchi,Shizuo Akira, Journal of Infection and Chemotherapy, Vol. 14, No. 2, p. 86-92, 2008/04
  • TLR9 as a key receptor for the recognition of DNA, Yutaro Kumagai,Osamu Takeuchi,Shizuo Akira, Advanced Drug Delivery Reviews, Vol. 60, No. 7, p. 795-804, 2008/04
  • Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBP 2-deficient hematopoietic cells, Tadayuki Akagi,Takayuki Saitoh,James O'Kelly,Shizuo Akira,Adrian F. Gombart,H. Phillip Koeffler, Blood, Vol. 111, No. 6, p. 2999-3004, 2008/03/15
  • Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway., Kiwamu Nakamura,Akiko Miyazato,Gang Xiao,Masumitsu Hatta,Ken Inden,Tetsuji Aoyagi,Kohei Shiratori,Kiyoshi Takeda,Shizuo Akira,Shinobu Saijo,Yoichiro Iwakura,Yoshiyuki Adachi,Naohito Ohno,Kazuo Suzuki,Jiro Fujita,Mitsuo Kaku,Kazuyoshi Kawakami, Journal of immunology (Baltimore, Md. : 1950), Vol. 180, No. 6, p. 4067-74, 2008/03/15
  • Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor, Junichi Nishimura,Hiroyuki Saiga,Shintaro Sato,Megumi Okuyama,Hisako Kayama,Hirotaka Kuwata,Sohkichi Matsumoto,Toshirou Nishida,Yoshiki Sawa,Shizuo Akira,Yasunobu Yoshikai,Masahiro Yamamoto,Kiyoshi Takeda, Journal of Immunology, American Association of Immunologists, Vol. 180, No. 6, p. 4032-4039, 2008/03/15
  • ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling, Chul-Su Yang,Dong-Min Shin,Hye-Mi Lee,Ji Woong Son,Sung Joong Lee,Shizuo Akira,Marie-Anne Gougerot-Pocidalo,Jamel El-Benna,Hidenori Ichijo,Eun-Kyeong Jo, CELLULAR MICROBIOLOGY, BLACKWELL PUBLISHING, Vol. 10, No. 3, p. 741-754, 2008/03
  • Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells, Jennifer P. A. Newman,Birendranath Banerjee,Wanru Fang,Anuradha Poonepalli,Lakshmidevi Balakrishnan,Grace Kah Mun Low,Rabindra N. Bhattacharjee,Shizuo Akira,Manikandan Jayapal,Alirio J. Melendez,Rajamanickam Baskar,Han-Woong Lee,M. Prakash Hande, JOURNAL OF CELLULAR PHYSIOLOGY, WILEY-LISS, Vol. 214, No. 3, p. 796-809, 2008/03
  • Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9, Christoph Hoelscher,Norbert Reiling,Ulrich E. Schaible,Alexandra Hoelscher,Clara Bathmann,Daniel Korbel,Insa Lenz,Tanja Sonntag,Svenja Kroeger,Shizuo Akira,Horst Mossmann,Carsten J. Kirschning,Hermann Wagner,Marina Freudenberg,Stefan Ehlers, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 38, No. 3, p. 680-694, 2008/03
  • Targeting dendritic cell signaling to regulate the response to immunization, David Escors,Luciene Lopes,Rongtuan Lin,John Hiscott,Shizuo Akira,Roger J. Davis,Mary K. Collins, BLOOD, AMER SOC HEMATOLOGY, Vol. 111, No. 6, p. 3050-3061, 2008/03
  • Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease, Matarn Vijay-Kumar,Jesse D. Aitken,Amrita Kumar,Andrew S. Neish,Satoshi Uematsu,Shizuo Akira,Andrew T. Gewirtz, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 76, No. 3, p. 1276-1281, 2008/03
  • Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells, Hajime Hisaeda,Kohhei Tetsutani,Takashi Imai,Chikako Moriya,Liping Tu,Shinjiro Hamano,Xuefeng Duan,Bin Chou,Hidekazu Ishida,Akiko Aramaki,Jianying Shen,Ken J. Ishii,Cevayir Coban,Shizuo Akira,Kiyoshi Takeda,Koji Yasutomo,Motomi Torii,Kunisuke Himeno, Journal of Immunology, American Association of Immunologists, Vol. 180, No. 4, p. 2496-2503, 2008/02/15
  • TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines, Ken J. Ishii,Tatsukata Kawagoe,Shohei Koyama,Kosuke Matsui,Himanshu Kumar,Taro Kawai,Satoshi Uematsu,Osamu Takeuchi,Fumihiko Takeshita,Cevayir Coban,Shizuo Akira, Nature, Vol. 451, No. 7179, p. 725-729, 2008/02/07
  • Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (Nature Immunology (2008) vol. 9 (97-104), Akira Goto,Kazufumi Matsushita,Viola Gesellchen,Laure El Chamy,David Kuttenkeuler,Osamu Takeuchi,Jules A. Hoffmann,Shizuo Akira,Michael Boutros,Jean Marc Reichhart, Nature Immunology, Vol. 9, No. 2, 2008/02
  • Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling, Nicholas S. Wilson,Louise J. Young,Fiona Kupresanin,Shalin H. Naik,David Vremec,William R. Heath,Shizuo Akira,Ken Shortman,Jeff Boyle,Eugene Maraskovsky,Gabrielle T. Belz,Jose A. Villadangos, IMMUNOLOGY AND CELL BIOLOGY, NATURE PUBLISHING GROUP, Vol. 86, No. 2, p. 200-205, 2008/02
  • Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity, Sun-Young Chang,Hye-Ran Cha,Satoshi Uematsu,Shizuo Akira,Osamu Igarashi,Hiroshi Kiyono,Mi-Na Kweon, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 180, No. 3, p. 1609-1618, 2008/02
  • MDA5/RIG-I and virus recognition, Osamu Takeuchi,Shizuo Akira, CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, Vol. 20, No. 1, p. 17-22, 2008/02
  • Activation of cytosolic phospholipase A(2)alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2, Shahid Noor,Howard Goldfine,Dawn E. Tucker,Saritha Suram,Laurel L. Lenz,Shizuo Akira,Satoshi Uematsu,Milena Girotti,Joseph V. Bonventre,Kevin Breuel,David L. Williams,Christina C. Leslie, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 283, No. 8, p. 4744-4755, 2008/02
  • Induction of prostaglandin E-2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors, Yoshiteru Nakano,Etsushi Kuroda,Tomohiro Kito,Satoshi Uematsu,SHizuo Akira,Akira Yokota,Shigeru Nishizawa,Uki Yamashita, JOURNAL OF NEUROSURGERY, AMER ASSOC NEUROLOGICAL SURGEONS, Vol. 108, No. 2, p. 311-319, 2008/02
  • Innate immunity and tubercfulosis, Satoshi Uematsu,Shizuo Akira, Kekkaku, Vol. 83, No. 2, p. 101-109, 2008/02
  • Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis, Jeremy B. Swann,Matthew D. Vesely,Anabel Silva,Janelle Sharkey,Shizuo Akira,Robert D. Schreiber,Mark J. Smyth, Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 2, p. 652-656, 2008/01/15
  • Cutting edge: Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses, Himanshu Kumar,Shohei Koyama,Ken J. Ishii,Taro Kawai,Shizuo Akira, Journal of Immunology, American Association of Immunologists, Vol. 180, No. 2, p. 683-687, 2008/01/15
  • Recognition of pathogens: Toll-like receptors, Satoshi Uematsu,Shizuo Akira, How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling, Springer Japan, p. 1-36, 2008
  • The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase, Sachie Hiratsuka,Akira Watanabe,Yoshiko Sakurai,Sachiko Akashi-Takamura,Sachie Ishibashi,Kensuke Miyake,Masabumi Shibuya,Shizuo Akira,Hiroyuki Aburatani,Yoshiro Maru, Nature Cell Biology, Vol. 10, No. 11, p. 1349-1355, 2008
  • Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability, Katalin Karikó,Hiromi Muramatsu,Frank A. Welsh,János Ludwig,Hiroki Kato,Shizuo Akira,Drew Weissman, Molecular Therapy, Vol. 16, No. 11, p. 1833-1840, 2008
  • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis, Shahla Abdollahi-Roodsaz,Leo A. B. Joosten,Marije I. Koenders,Isabel Devesa,Mieke F. Roelofs,Timothy R. D. J. Radstake,Marleen Heuvelmans-Jacobs,Shizuo Akira,Martin J. H. Nicklin,Fatima Ribeiro-Dias,Wim B. Van den Berg, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 118, No. 1, p. 205-216, 2008/01
  • Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess, Werner Stenzel,Sabine Soltek,Monica Sanchez-Ruiz,Shizuo Akira,Hrvoje Miletic,Dirk Schlueter,Martina Deckert, AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, Vol. 172, No. 1, p. 132-145, 2008/01
  • Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity, Yueh-Ming Loo,Jamie Fornek,Nanette Crochet,Gagan Bajwa,Olivia Perwitasari,Luis Martinez-Sobrido,Shizuo Akira,Michelle A. Gill,Adolfo Garcia-Sastre,Michael G. Katze,Michael Gale, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 82, No. 1, p. 335-345, 2008/01
  • Akirins are highly conserved nuclear proteins required for NF-kappa B-dependent gene expression in drosophila and mice, Akira Goto,Kazufumi Matsushita,Viola Gesellchen,Laure El Chamy,David Kuttenkeuler,Osamu Takeuchi,Jules A. Hoffmann,Shizuo Akira,Michael Boutros,Jean-Marc Reichhart, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 9, No. 1, p. 97-104, 2008/01
  • Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders, Kiyofumi Yamakawa,Satoru Kamekura,Naohiro Kawamura,Masatomo Saegusa,Daisuke Kamei,Makoto Murakami,Ichiro Kudo,Satoshi Uematsu,Shizuo Akira,Ung-Il Chung,Kozo Nakamura,Hiroshi Kawaguchi, ARTHRITIS AND RHEUMATISM, WILEY-LISS, Vol. 58, No. 1, p. 172-183, 2008/01
  • Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling, Rabindra N. Bhattacharjee,Kwon-Sam Park,Xiuhao Chen,Tetsuya Lida,Takeshi Hondal,Osamu Takeuchi,Shizuo Akira, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY, Vol. 18, No. 1, p. 171-175, 2008/01
  • Toll-like receptor and RIG-1-like receptor signaling, Taro Kawai,Shizuo Akira, Annals of the New York Academy of Sciences, Blackwell Publishing Inc., Vol. 1143, p. 1-20, 2008
  • Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88, Andreas Jung,Hiroki Kato,Yutaro Kumagai,Himanshu Kumar,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Journal of Virology, Vol. 82, No. 1, p. 196-206, 2008/01
  • Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif, Issa Abu-Dayyeh,Marina Tiemi Shio,Shintaro Sato,Shizuo Akira,Benoit Cousineau,Martin Olivier, PLoS Neglected Tropical Diseases, Vol. 2, No. 12, 2008
  • Toll-like receptors (TLRs) and their ligands, Satoshi Uematsu,Shizuo Akira, Handbook of Experimental Pharmacology, Vol. 183, No. 183, p. 1-20, 2008
  • Loss of Atg16L1, an autophagy regulator, enhances endotoxin-induced IL-1 production, Saitoh, T,Fujita, N,Ho Jang,M. H,Uematsu, S,Yang, B-C,Satoh, T,Omori, H,Noda, T,Yamamoto, N,Komatsu, M,Tanaka, K,Kawai, T,Tsujimura, T,Takeuchi, O,Yoshimori, T,Akira, S, Nature, Vol. 456, p. 264-268, 2008
  • Immunoadjuvant effects of polyadenylic: Polyuridylic acids through TLR3 and TLR7, Takahiro Sugiyama,Katsuaki Hoshino,Masuyoshi Saito,Takahiro Yano,Izumi Sasaki,Chihiro Yamazaki,Shizuo Akira,Tsuneyasu Kaisho, International Immunology, Vol. 20, No. 1, p. 1-9, 2008/01
  • IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice, Pamela Gasse,Caroline Mary,Isabelle Guenon,Nicolas Noulin,Sabine Charron,Silvia Schnyder-Candrian,Bruno Schnyder,Shizuo Akira,Valerie F. J. Quesniaux,Vincent Lagente,Bernhard Ryffel,Isabelle Couillin, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 117, No. 12, p. 3786-3799, 2007/12
  • IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc epsilon RI signals, Lien H. Ho,Tatsukuni Ohno,Keisuke Oboki,Naoki Kajiwara,Hajime Suto,Motoyasu Iikura,Yoshimichi Okayama,Shizuo Akira,Hirohisa Saito,Stephen J. Galli,Susumu Nakae, JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, Vol. 82, No. 6, p. 1481-1490, 2007/12
  • Deletion of TLR5 results in spontaneous colitis in mice, Matam Vijay-Kumar,Catherine J. Sanders,Rebekah T. Taylor,Amrita Kumar,Jesse D. Aitken,Shanthi V. Sitaraman,Andrew S. Neish,Satoshi Uematsu,Shizuo Akira,Ifor R. Williams,Andrew T. Gewirtz, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 117, No. 12, p. 3909-3921, 2007/12
  • Recognition of viruses by innate immunity, Osamu Takeuchi,Shizuo Akira, IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL, Vol. 220, No. 1, p. 214-224, 2007/12
  • The HTLV-I Tax oncoprotein requires the ubiquitin conjugating enzyme Ubc13 for NF-κB activation., Shembade N,Harhaj NS,Yamamoto M,Akira S,Harhaj EW, <i><b> J Virol.</b></i>, Vol. 81, No. 24, p. 13735-13742, 2007/12
  • Modified vaccinia virus Ankara induces toll-like receptor-independent type I interferon responses, Zoe Waibler,Martina Anzaghe,Holger Ludwig,Shizuo Akira,Siegfried Weiss,Gerd Sutter,Ulrich Kalinke, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 81, No. 22, p. 12102-12110, 2007/11
  • Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila, Thomas R. Hawn,William R. Berrington,Ian A. Smith,Satoshi Uematsu,Shizuo Akira,Alan Aderem,Kelly D. Smith,Shawn J. Skerrett, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 179, No. 10, p. 6981-6987, 2007/11
  • FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction, Rachel Zhande,Shauna M. Dauphinee,James A. Thomas,Masahiro Yamamoto,Shizuo Akira,Aly Karsan, Molecular and Cellular Biology, Vol. 27, No. 21, p. 7394-7404, 2007/11
  • Signal Transducer and Activator of Transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice, Ryotaro Sakamori,Tetsuo Takehara,Chihiro Ohnishi,Tomohide Tatsumi,Kazuyoshi Ohkawa,Kiyoshi Takeda,Shizuo Akira,Norio Hayashi, Hepatology, Vol. 46, No. 5, p. 1564-1573, 2007/11
  • Signaling to NF-κB by Toll-like receptors, Taro Kawai,Shizuo Akira, Trends in Molecular Medicine, Vol. 13, No. 11, p. 460-469, 2007/11
  • The C/EBPβ isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing, Satoshi Uematsu,Tsuneyasu Kaisho,Takashi Tanaka,Makoto Matsumoto,Megumi Yamakami,Hiroko Omori,Masahiro Yamamoto,Tamotsu Yoshimori,Shizuo Akira, Journal of Immunology, Vol. 179, No. 8, p. 5378-5386, 2007/10/15
  • Calcineurin negatively regulates TLR-Mediated activation pathways, Young Jun Kang,Brenda Kusler,Motoyuki Otsuka,Michael Hughes,Nobutaka Suzuki,Shinobu Suzuki,Wen-Chen Yeh,Shizuo Akira,Jiahuai Han,Patricia P. Jones, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 179, No. 7, p. 4598-4607, 2007/10
  • Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif, Pamela Cook,Sabine Toetemeyer,Catherine Stevenson,Katherine A. Fitzgerald,Masahiro Yamamoto,Shizuo Akira,Duncan J. Maskell,Clare E. Bryant, IMMUNOLOGY, BLACKWELL PUBLISHING, Vol. 122, No. 2, p. 222-229, 2007/10
  • Genetic analysis of resistance to viral infection, Bruce Beutler,Celine Eidenschenk,Karine Crozat,Jean-Luc Imler,Osamu Takeuchi,Jules A. Hoffmann,Shizuo Akira, NATURE REVIEWS IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 7, No. 10, p. 753-766, 2007/10
  • Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination, Shohei Koyama,Ken J. Ishii,Himanshu Kumar,Takeshi Tanimoto,Cevayir Coban,Satoshi Uematsu,Taro Kawai,Shizuo Akira, Journal of Immunology, American Association of Immunologists, Vol. 179, No. 7, p. 4711-4720, 2007/10/01
  • Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance, Subhra K. Biswas,Pradeep Bist,Manprit Kaur Dhillon,Tasneem Kajiji,Carlos Del Fresno,Masahiro Yamamoto,Eduardo Lopez-Collazo,Shizuo Akira,Vinay Tergaonkar, Journal of Immunology, American Association of Immunologists, Vol. 179, No. 6, p. 4083-4092, 2007/09/15
  • Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency, Masahiro Yamamoto,Satoshi Uematsu,Toru Okamoto,Yoshiharu Matsuura,Shintaro Sato,Himanshu Kumar,Takashi Satoh,Tatsuya Saitoh,Kiyoshi Takeda,Ken J. Ishii,Osamu Takeuchi,Taro Kawai,Shizuo Akira, Journal of Experimental Medicine, Vol. 204, No. 9, p. 2233-2239, 2007/09/03
  • MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus, Karl Lang,Alexander A. Navarini,Mike Recher,Philipp A. Lang,Mathias Heikenwalder,Barbara Stecher,Andreas Bergthaler,Bernhard Odermatt,Shizuo Akira,Kenya Honda,Hans Hengartner,Rolf M. Zinkernagel, European Journal of Immunology, Vol. 37, No. 9, p. 2434-2440, 2007/09
  • TLR9 is required for protective innate immunity in gram-negative bacterial pneumonia: Role of dendritic cells, Urvashi Bhan,Nicholas W. Lukacs,John J. Osterholzer,Michael W. Newstead,Xianying Zeng,Thomas A. Moore,Tracy R. McMillan,Arthur M. Krieg,Shizuo Akira,Theodore J. Standiford, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 179, No. 6, p. 3937-3946, 2007/09
  • Nitrogen dioxide promotes allergic Sensitization to inhaled antigen, Mieke Bevelander,Jana Mayette,Laurie A. Whittaker,Sara A. Paveglio,Christine C. Jones,Justin Robbins,David Hemenway,Shizuo Akira,Satoshi Uematsu,Matthew E. Poynter, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 179, No. 6, p. 3680-3688, 2007/09
  • Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines, Takayuki Abe,Yuuki Kaname,Itsuki Hamamoto,Yoshimi Tsuda,Xiaoyu Wen,Shuhei Taguwa,Kohji Moriishi,Osamu Takeuchi,Taro Kawai,Tatsuya Kanto,Norio Hayashi,Shizuo Akira,Yoshiharu Matsuura, Journal of Virology, Vol. 81, No. 17, p. 8953-8966, 2007/09
  • The Atg5-Atg12 conjugate associates with innate antiviral immune responses, Nao Jounai,Fumihiko Takeshita,Kouji Kobiyama,Asako Sawano,Atsushi Miyawaki,Ke-Qin Xin,Ken J. Ishii,Taro Kawai,Shizuo Akira,Koichi Suzuki,Kenji Okuda, Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 35, p. 14050-14055, 2007/08/28
  • Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses, Yutaro Kumagai,Osamu Takeuchi,Hiroki Kato,Himanshu Kumar,Kosuke Matsui,Eiichi Morii,Katsuyuki Aozasa,Taro Kawai,Shizuo Akira, Immunity, Vol. 27, No. 2, p. 240-252, 2007/08/24
  • Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells, Hiroyuki Tezuka,Yukiko Abe,Makoto Iwata,Hajime Takeuchi,Hiromichi Ishikawa,Masayuki Matsushita,Tetsuo Shiohara,Shizuo Akira,Toshiaki Ohteki, NATURE, NATURE PUBLISHING GROUP, Vol. 448, No. 7156, p. 929-U7, 2007/08
  • Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes, Hun Sik Kim,Myoung Sook Han,Kun Wook Chung,Sunshin Kim,Eunshil Kim,Myoung Joo Kim,Eunkyeong Jang,Hyun Ah Lee,Jeehee Youn,Shizuo Akira,Myung-Shik Lee, IMMUNITY, CELL PRESS, Vol. 27, No. 2, p. 321-333, 2007/08
  • Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself, Jiali Li,Wenru Song,Debra K. Czerwinski,Bindu Varghese,Satoshi Uematsu,Shizuo Akira,Arthur M. Krieg,Ronald Levy, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 179, No. 4, p. 2493-2500, 2007/08
  • Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine, Sukumar Saha,Fumihiko Takeshita,Tomoko Matsuda,Nao Jounai,Kouji Kobiyama,Tetsuya Matsumoto,Shin Sasaki,Atsushi Yoshida,Ke-Qin Xin,Dennis M. Klinman,Satoshi Uematsu,Ken J. Ishii,Shizuo Akira,Kenji Okuda, Journal of Immunology, American Association of Immunologists, Vol. 179, No. 2, p. 1147-1154, 2007/07/15
  • Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice, Ganesan Ramesh,Binzhi Zhang,Satoshi Uematsu,Shizuo Akira,W. Brian Reeves, American Journal of Physiology - Renal Physiology, Vol. 293, No. 1, p. F325-F332, 2007/07
  • Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population, Kayoko Tao,Mutsuko Fujii,Shin-Ichi Tsukumo,Yoichi Maekawa,Kenji Kishihara,Yasutaka Kimoto,Takahiko Horiuchi,Hajime Hisaeda,Shizuo Akira,Shoji Kagami,Koji Yasutomo, Annals of the Rheumatic Diseases, Vol. 66, No. 7, p. 905-909, 2007/07
  • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells, Chun-Jen Chen,Hajime Kono,Douglas Golenbock,George Reed,Shizuo Akira,Kenneth L. Rock, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 13, No. 7, p. 851-856, 2007/07
  • Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes, Fumiyo Ikeda,Christina Maria Hecker,Alexis Rozenknop,Rolf Dietrich Nordmeier,Vladimir Rogov,Kay Hofmann,Shizuo Akira,Volker Doetsch,Ivan Dikic, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 26, No. 14, p. 3451-3462, 2007/07
  • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and toll-like receptors, Jin-Hwan Han,Shizuo Akira,Kathryn Calame,Bruce Beutler,Erik Selsing,Thereza Imanishi-Kari, IMMUNITY, CELL PRESS, Vol. 27, No. 1, p. 64-75, 2007/07
  • The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis, Zachary J. Roberts,Nadege Goutagny,Pin-Yu Perera,Hiroki Kato,Himanshu Kumar,Taro Kawai,Shizuo Akira,Ram Savan,David van Echo,Katherine A. Fitzgerald,Howard A. Young,Lai-Ming Ching,Stefanie N. Vogel, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 204, No. 7, p. 1559-1569, 2007/07
  • A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells, Naohiko Shimada,Cevayir Coban,Yoichi Takeda,Masami Mizu,Jusaku Minari,Takahisa Anada,Yuichi Torii,Seiji Shinkai,Shizuo Akira,Ken J. Ishii,Kazuo Sakurai, Bioconjugate Chemistry, Vol. 18, No. 4, p. 1280-1286, 2007/07
  • Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice., Ramesh G,Zhang B,Uematsu S,Akira S,Reeves WB, American journal of physiology. Renal physiology, Vol. 293, No. 1, p. F325-32, 2007/07
  • Murine dendritic cell type IIFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production, Kei Yasuda,Christophe Richez,Joseph W. Maciaszek,Neerja Agrawal,Shizuo Akira,Ann Marshak-Rothstein,Ian R. Rifkin, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 178, No. 11, p. 6876-6885, 2007/06
  • Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a, Doo-Hee Shim,Sun-Young Chang,Sung-Moo Park,Hyun Jang,Rodney Carbis,Cecil Czerkinsky,Satoshi Uematsu,Shizuo Akira,Mi-Na Kweon, VACCINE, ELSEVIER SCI LTD, Vol. 25, No. 25, p. 4828-4836, 2007/06
  • ER stress triggers apoptosis by activating BH3-only protein Bim, Hamsa Puthalakath,Lorraine A. O&apos;Reilly,Priscilla Gunn,Lily Lee,Priscilla N. Kelly,Nicholas D. Huntington,Peter D. Hughes,Ewa M. Michalak,Jennifer McKimm-Breschkin,Noburo Motoyama,Tomomi Gotoh,Shizuo Akira,Philippe Bouillet,Andreas Strasser, CELL, CELL PRESS, Vol. 129, No. 7, p. 1337-1349, 2007/06
  • SnapShot: Pattern-recognition receptors., Kawai T,Akira S, Cell, Vol. 129, No. 5, 2007/06
  • Manipulation of host innate immune responses by the malaria parasite, Cevayir Coban,Ken J. Ishii,Toshihiro Horii,Shizuo Akira, Trends in Microbiology, Vol. 15, No. 6, p. 271-278, 2007/06
  • Cutting edge: TLR2 directly triggers Th1 effector functions, Takayuki Imanishi,Hiromitsu Hara,Shinobu Suzuki,Nobutaka Suzuki,Shizuo Akira,Takashi Saito, Journal of Immunology, American Association of Immunologists, Vol. 178, No. 11, p. 6715-6719, 2007/06/01
  • Toll-like receptors and type I Interferons, Satoshi Uematsu,Shizuo Akira, Journal of Biological Chemistry, Vol. 282, No. 21, p. 15319-15324, 2007/05/25
  • Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia, Mark C. Dessing,Koenraad F. van der Sluijs,Sandrine Florquin,Shizuo Akira,Tom van der Poll, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, AMER THORACIC SOC, Vol. 36, No. 5, p. 609-614, 2007/05
  • A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity, Donghoon Kim,Myung Ah Kim,Ik-Hyun Cho,Mi Sun Kim,Soojin Lee,Eun-Kyeong Jo,Se-Young Choi,Kyungpyo Park,Joong Soo Kim,Shizuo Akira,Heung Sik Na,Seog Bae Oh,Sung Joong Lee, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 282, No. 20, p. 14975-14983, 2007/05
  • Deficiencies of myeloid differentiation factor 88, toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori, Marygorret Obonyo,Mojgan Sabet,Sheri P. Cole,Joerg Ebmeyer,Satoshi Uematsu,Shizuo Akira,Donald G. Guiney, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 75, No. 5, p. 2408-2414, 2007/05
  • Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling, Tatsukata Kawagoe,Shintaro Sato,Andreas Jung,Masahiro Yamamoto,Kosuke Matsui,Hiroki Kato,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira, Journal of Experimental Medicine, Vol. 204, No. 5, p. 1013-1024, 2007/05
  • Interleukin-18 regulates pathological intraocular neovascularization, Hong Qiao,Koh-Hei Sonoda,Yasuhiro Ikeda,Takeru Yoshimura,Kuniaki Hijioka,Young-Joon Jo,Yukio Sassa,Chikako Tsutsumi-Miyahara,Yasuaki Hata,Shizuo Akira,Tatsuro Ishibashi, Journal of Leukocyte Biology, Vol. 81, No. 4, p. 1012-1021, 2007/04
  • Cutting edge: Tlr5(-/-) mice are more susceptible to Escherichia coli urinary tract infection, Erica Andersen-Nissen,Thomas R. Hawn,Kelly D. Smith,Alex Nachman,Aaron E. Lampano,Satoshi Uematsu,Shizuo Akira,Alan Aderem, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 178, No. 8, p. 4717-4720, 2007/04
  • Signaling pathways activated by microorganisms, Osamu Takeuchi,Shizuo Akira, CURRENT OPINION IN CELL BIOLOGY, CURRENT BIOLOGY LTD, Vol. 19, No. 2, p. 185-191, 2007/04
  • TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity, Michaela U. Gack,Young C. Shin,Chul-Hyun Joo,Tomohiko Urano,Chengyu Liang,Lijun Sun,Osamu Takeuchi,Shizuo Akira,Zhijian Chen,Satoshi Inoue,Jae U. Jung, NATURE, NATURE PUBLISHING GROUP, Vol. 446, No. 7138, p. 916-U2, 2007/04
  • Viral infections activate types I and III interferon genes through a common mechanism, Kazuhide Onoguchi,Mitsutoshi Yoneyama,Azumi Takemura,Shizuo Akira,Tadatsugu Taniguchi,Hideo Namiki,Takashi Fujita, Journal of Biological Chemistry, Vol. 282, No. 10, p. 7576-7581, 2007/03/02
  • Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFκB activation pathways bifurcate at IL-1 receptor-associated kinase modification, Jianhong Yao,Whan Kim Tae,Jinzhong Qin,Zhengfan Jiang,Youcun Qian,Hui Xiao,Yi Lu,Wen Qian,Muhammet Fatih Gulen,Nywana Sizemore,Joseph DiDonato,Shintaro Sato,Shizuo Akira,Bing Su,Xiaoxia Li, Journal of Biological Chemistry, Vol. 282, No. 9, p. 6075-6089, 2007/03/02
  • Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection, Barbara Albiger,Sofia Dahlberg,Andreas Sandgren,Florian Wartha,Katharina Beiter,Hiroaki Katsuragi,Shizuo Akira,Staffan Normark,Birgitta Henriques-Normark, Cellular Microbiology, Vol. 9, No. 3, p. 633-644, 2007/03
  • Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo, Svetlana Hamm,Antje Heit,Martina Koffler,Katharina M. Huster,Shizuo Akira,Dirk H. Busch,Herrmann Wagner,Stefan Bauer, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 19, No. 3, p. 297-304, 2007/03
  • MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses, Kishore R. Alugupalli,Shizuo Akira,Egil Lien,John M. Leong, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 178, No. 6, p. 3740-3749, 2007/03
  • Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways, Junko Sawaki,Hiroko Tsutsui,Nobuki Hayashi,Koubun Yasuda,Shizuo Akira,Takakuni Tanizawa,Kenji Nakanishi, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 19, No. 3, p. 311-320, 2007/03
  • A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-β in the host response to Pseudomonas aeruginosa lung infection in mice, Melanie R. Power,Bo Li,Masahiro Yamamoto,Shizuo Akira,Tong-Jun Lin, Journal of Immunology, Vol. 178, No. 5, p. 3170-3176, 2007/03/01
  • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia, Samithamby Jeyaseelan,Scott K. Young,Michael B. Fessler,Yuhong Liu,Kenneth C. Malcolm,Masahiro Yamamoto,Shizuo Akira,G. Scott Worthen, Journal of Immunology, Vol. 178, No. 5, p. 3153-3160, 2007/03/01
  • Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon, Luisa Cervantes-Barragan,Roland Zuest,Friedernann Weber,Martin Spiegel,Karl S. Lang,Shizuo Akira,Volker Thiel,Burkhard Ludewig, BLOOD, AMER SOC HEMATOLOGY, Vol. 109, No. 3, p. 1131-1137, 2007/02
  • TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses, Alex K. Heer,Abdijapar Shamshiev,Alena Donda,Satoshi Uematsu,Shizuo Akira,Manfred Kopf,Benjamin J. Marsland, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 178, No. 4, p. 2182-2191, 2007/02
  • NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1, Sinead M. Miggin,Eva Palsson-McDermott,Aisling Dunne,Caroline Jefferies,Emmanuel Pinteaux,Kathy Banahan,Caroline Murphy,Paul Moynagh,Masahiro Yamamoto,Shizuo Akira,Nancy Rothwelll,Douglas Golenbock,Katherine A. Fitzgerald,Luke A. J. O'Neill, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 104, No. 9, p. 3372-3377, 2007/02
  • TLR signaling, Taro Kawai,Shizuo Akira, Seminars in Immunology, Vol. 19, No. 1, p. 24-32, 2007/02
  • Antiviral signaling through pattern recognition receptors, Taro Kawai,Shizuo Akira, Journal of Biochemistry, Vol. 141, No. 2, p. 137-145, 2007/02
  • Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans, Shinobu Saijo,Noriyuki Fujikado,Takahisa Furuta,Soo-Hyun Chung,Hayato Kotaki,Keisuke Seki,Katsuko Sudo,Shizuo Akira,Yoshiyuki Adachi,Naohito Ohno,Takeshi Kinjo,Kiwamu Nakamura,Kazuyoshi Kawakami,Yoichiro Iwakura, Nature Immunology, Vol. 8, No. 1, p. 39-46, 2007/01
  • The Biology of Toll-Like Receptors in Mice, Osamu Takeuchi,Shizuo Akira, The Mouse in Biomedical Research, Vol. 4, p. 109-117, 2007
  • Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2, Takeshi Saito,Reiko Hirai,Yueh-Ming Loo,David Owen,Cynthia L. Johnson,Sangita C. Sinha,Shizuo Akira,Takashi Fujita,Michael Gale, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 104, No. 2, p. 582-587, 2007/01
  • Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury, Yasushi Sakata,Jian-Wen Dong,Jesus G. Vallejo,Chien-Hua Huang,J. Scott Baker,Kevin J. Tracey,Osamu Tacheuchi,Shizuo Akira,Douglas L. Mann, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Vol. 292, No. 1, p. H503-H509, 2007/01
  • DNA and RNA autoantigens as autoadjuvants, Liliana Busconi,Christina M. Lau,Abigail S. Tabor,Melissa B. Uccellini,Zachary Ruhe,Shizuo Akira,Gregory A. Viglianti,Ian R. Rifkin,Ann Marshak-Rothstein, Journal of Endotoxin Research, Vol. 12, No. 6, p. 379-384, 2006/12
  • IL-21-induced B epsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses, Michishige Harada,Kumiko Magara-Koyanagi,Hiroshi Watarai,Yuko Nagata,Yasuyuki Ishii,Satoshi Kojo,Shigetoshi Horiguchi,Yoshitaka Okamoto,Toshinori Nakayama,Nobutaka Suzuki,Wen-Chen Yeh,Shizuo Akira,Hiroshi Kitamura,Osamu Ohara,Ken-ichiro Seino,Masaru Taniguchi, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 203, No. 13, p. 2929-2937, 2006/12
  • Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals, Andre Boonstra,Ricardo Rajsbaum,Mary Holman,Rute Marques,Carine Asselin-Paturel,Joao Pedro Pereira,Elizabeth E. M. Bates,Shizuo Akira,Paulo Vieira,Yong-Jun Liu,Giorgio Trinchieri,Anne O'Garra, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 177, No. 11, p. 7551-7558, 2006/12
  • Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis, Takahisa Furuta,Takane Kikuchi,Shizuo Akira,Naohiro Watanabe,Yasuhiro Yoshikawa, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 18, No. 12, p. 1655-1662, 2006/12
  • Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides, Sandra S. Diebold,Catherine Massacrier,Shizuo Akira,Carine Paturel,Yannis Morel,Caetano Reis e Sousa, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 36, No. 12, p. 3256-3267, 2006/12
  • Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp., Devin D. Bolz,Rhianna S. Sundsbak,Ying Ma,Shizuo Akira,John H. Weis,Tom G. Schwan,Janis J. Weis, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 74, No. 12, p. 6750-6760, 2006/12
  • Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling, Ranmal Samarasinghe,Prafullakumar Tailor,Tomohiko Tamura,Tsuneyasu Kaisho,Shizuo Akira,Keiko Ozato, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT INC, Vol. 26, No. 12, p. 893-900, 2006/12
  • Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade, Min-Kyung Choo,Noritaka Kawasaki,Pattama Singhirunnusorn,Keiichi Koizumi,Shintaro Sato,Shizuo Akira,Ikuo Saiki,Hiroaki Sakurai, Molecular Cancer Therapeutics, Vol. 5, No. 12, p. 2970-2976, 2006/12
  • Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling, Masahiro Yamamoto,Shintaro Sato,Tatsuya Saitoh,Hiroaki Sakurai,Satoshi Uematsu,Taro Kawai,Ken J. Ishii,Osamu Takeuchi,Shizuo Akira, Journal of Immunology, Vol. 177, No. 11, p. 7520-7524, 2006/12/01
  • VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition, Rabindra N. Bhattacharjee,Kwon Sam Park,Yutaro Kumagai,Kazuhisa Okada,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Himanshu Kumar,Taro Kawai,Tetsuya Iida,Takeshi Honda,Osamu Takeuchi,Shizuo Akira, Journal of Biological Chemistry, Vol. 281, No. 48, p. 36897-36904, 2006/12/01
  • 5 &apos;-triphosphate RNA is the ligand for RIG-I, Veit Hornung,Jana Ellegast,Sarah Kim,Krzysztof Brzozka,Andreas Jung,Hiroki Kato,Hendrik Poeck,Shizuo Akira,Karl-Klaus Conzelmann,Martin Schlee,Stefan Endres,Gunther Hartmann, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 314, No. 5801, p. 994-997, 2006/11
  • Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways, Dieudonnee Togbe,Gorse Aurore,Nicolas Noulin,Valerie F. J. Quesniaux,Silvia Schnyder-Candrian,Bruno Schnyder,Virginie Vasseur,Shizuo Akira,Kasper Hoebe,Bruce Beutler,Bernhard Ryffel,Isabelle Couillin, LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, Vol. 86, No. 11, p. 1126-1135, 2006/11
  • Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf, Amal Amer,Luigi Franchi,Thirumala-Devi Kanneganti,Mathilde Body-Malapel,Nesrin Ozoren,Graham Brady,Sasha Meshinchi,Rajesh Jagirdar,Andrew Gewirtz,Shizuo Akira,Gabriel Nunez, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 281, No. 46, p. 35217-35223, 2006/11
  • The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice, M. R. Power,J. S. Marshall,M. Yamamoto,S. Akira,T. J. Lin, Clinical and Experimental Immunology, Vol. 146, No. 2, p. 323-329, 2006/11
  • Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells, Kosuke Matsui,Yutaro Kumagai,Hiroki Kato,Shintaro Sato,Tatsukata Kawagoe,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira, Journal of Immunology, Vol. 177, No. 9, p. 5785-5789, 2006/11/01
  • Impaired postnatal development in C/EBP β-deficient mice, Tao Bai,Tetsuji Tanaka,Kazunori Yukawa,Naohiko Umesaki,Makoto Matsumoto,Shizuo Akira, Journal of Reproduction and Development, Vol. 52, No. 5, p. 645-649, 2006/10
  • TLR engagement prevents transplantation tolerance, L. Chen,T. Wang,P. Zhou,L. Ma,D. Yin,J. Shen,L. Molinero,T. Nozaki,T. Phillips,S. Uematsu,S. Akira,C. R. Wang,R. L. Fairchild,M. L. Alegre,A. Chong, American Journal of Transplantation, Vol. 6, No. 10, p. 2282-2291, 2006/10
  • Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10, Todd Wuest,Bobbie Ann Austin,Satoshi Uematsu,Manoj Thapa,Shizuo Akira,Daniel J. J. Carr, JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, Vol. 179, No. 1-2, p. 46-52, 2006/10
  • TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells, Shintaro Sato,Hideki Sanjo,Tohru Tsujimura,Jun Ninomiya-Tsuji,Masahiro Yamamoto,Taro Kawai,Osamu Takeuchi,Shizuo Akira, International Immunology, Vol. 18, No. 10, p. 1405-1411, 2006/10
  • TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation, Hokuto Kamon,Takaya Kawabe,Hidemitsu Kitamura,Jihye Lee,Daisuke Kamimura,Tsuneyasu Kaisho,Shizuo Akira,Akihiro Iwamatsu,Hisashi Koga,Masaaki Murakami,Toshio Hirano, EMBO Journal, 17, Vol. 25, No. 17, p. 4108-4119, 2006/09/06
  • PRRs in pathogen recognition, Satoshi Uematsu,Shizuo Akira, CENTRAL EUROPEAN JOURNAL OF BIOLOGY, VERSITA, Vol. 1, No. 3, p. 299-313, 2006/09
  • Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling, Karl S. Lang,Panco Georgiev,Mike Recher,Alexander A. Navarini,Andreas Bergthaler,Mathias Heikenwalder,Nicola L. Harris,Tobias Junt,Bernhard Odermatt,Pierre-Alain Clavien,Hanspeter Pircher,Shizuo Akira,Hans Hengartner,Rolf M. Zinkernagel, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 116, No. 9, p. 2456-2463, 2006/09
  • Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice, Robert Berland,Luis Fernandez,Elina Kari,Jin-Hwan Han,Ina Lomakin,Shizuo Akira,Henry H. Wortis,John F. Kearney,Angelo A. Ucci,Thereza Imanishi-Kari, IMMUNITY, CELL PRESS, Vol. 25, No. 3, p. 429-440, 2006/09
  • Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region, Takako Takemiya,Michiyo Maehara,Kiyoshi Matsumura,Shin Yasuda,Hiroko Sugiura,Kanato Yamagata, Neuroscience Research, Vol. 56, No. 1, p. 103-110, 2006/09
  • Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways, Wei-Chun HuangFu,Emily Omori,Shizuo Akira,Kunihiro Matsumoto,Jun Ninomiya-Tsuji, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 281, No. 39, p. 28802-28810, 2006/09
  • Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function, Hidemitsu Kitamura,Hideyuki Morikawa,Hokuto Kamon,Megumi Iguchi,Shintaro Hojyo,Toshiyuki Fukada,Susumu Yamashita,Tsuneyasu Kaisho,Shizuo Akira,Masaaki Murakami,Toshio Hirano, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 7, No. 9, p. 971-977, 2006/09
  • Toll-like receptors and innate immunity, Satoshi Uematsu,Shizuo Akira, Journal of Molecular Medicine, Vol. 84, No. 9, p. 712-725, 2006/09
  • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Masahiro Yamamoto,Toru Okamoto,Kiyoshi Takeda,Shintaro Sato,Hideki Sanjo,Satoshi Uematsu,Tatsuya Saitoh,Naoki Yamamoto,Hiroaki Sakurai,Ken J. Ishii,Shoji Yamaoka,Taro Kawai,Yoshiharu Matsuura,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 9, p. 962-970, 2006/09
  • Transforming growth factor-β-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis, Koji Sayama,Yasushi Hanakawa,Hiroshi Nagai,Yuji Shirakata,Xiuju Dai,Satoshi Hirakawa,Sho Tokumaru,Mikiko Tohyama,Lujun Yang,Shintaro Sato,Akira Shizuo,Koji Hashimoto, Journal of Biological Chemistry, Vol. 281, No. 31, p. 22013-22020, 2006/08/04
  • Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses, Katja Fink,Karl S. Lang,Nataly Manjarrez-Orduno,Tobias Junt,Beatrice M. Senn,Martin Holdener,Shizuo Akira,Rolf M. Zinkernagel,Hans Hengartner, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 36, No. 8, p. 2094-2105, 2006/08
  • MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals, Chun-Jen Chen,Yan Shi,Arron Hearn,Kate Fitzgerald,Douglas Golenbock,George Reed,Shizuo Akira,Kenneth L. Rock, JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, Vol. 116, No. 8, p. 2262-2271, 2006/08
  • Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages, Leesun Kim,Barbara A. Butcher,Chiang W. Lee,Satoshi Uematsu,Shizuo Akira,Eric Y. Denkers, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 177, No. 4, p. 2584-2591, 2006/08
  • Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury, Yuri Ikeda-Matsuo,Azusa Ota,Tetsuya Fukada,Satoshi Uematsu,Shizuo Akira,Yasuharu Sasaki, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 103, No. 31, p. 11790-11795, 2006/08
  • CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation, Ken Shirakawa,Shingo Maeda,Tomomi Gotoh,Makoto Hayashi,Kenichi Shinomiya,Shogo Ehata,Riko Nishimura,Masataka Mori,Kikuo Onozaki,Hidetoshi Hayashi,Satoshi Uematsu,Shizuo Akira,Etsuro Ogata,Kohei Miyazono,Takeshi Imamura, MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, Vol. 26, No. 16, p. 6105-6116, 2006/08
  • Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E 2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation, Masaki Inada,Chiho Matsumoto,Satoshi Uematsu,Shizuo Akira,Chisato Miyaura, Journal of Immunology, American Association of Immunologists, Vol. 177, No. 3, p. 1879-1885, 2006/08/01
  • Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c<sup>+</sup> lamina propria cells, Satoshi Uematsu,Myoung Ho Jang,Nicolas Chevrier,Zijin Guo,Yutaro Kumagai,Masahiro Yamamoto,Hiroki Kato,Nagako Sougawa,Hidenori Matsui,Hirotaka Kuwata,Hiroaki Hemmi,Cevayir Coban,Taro Kawai,Ken J. Ishii,Osamu Takeuchi,Masayuki Miyasaka,Kiyoshi Takeda,Shizuo Akira, Nature Immunology, Vol. 7, No. 8, p. 868-874, 2006/08
  • TLR8-mediated NF-κB and JNK activation are TAK1-independent and MEKK3-dependent, Jinzhong Qin,Jianhong Yao,Grace Cui,Hui Xiao,Whan Kim Tae,Jerzy Fraczek,Paul Wightman,Shintaro Sato,Shizuo Akira,Anne Puel,Jean-Laurent Casanova,Bing Su,Xiaoxia Li, Journal of Biological Chemistry, Vol. 281, No. 30, p. 21013-21021, 2006/07/28
  • TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis, Emily Omori,Kunihiro Matsumoto,Hideki Sanjo,Shintaro Sato,Shizuo Akira,Robert C. Smart,Jun Ninomiya-Tsuji, Journal of Biological Chemistry, Vol. 281, No. 28, p. 19610-19617, 2006/07/14
  • Essential role of IPS-1 in innate immune responses against RNA viruses, Himanshu Kumar,Taro Kawai,Hiroki Kato,Shintaro Sato,Ken Takahashi,Cevayir Coban,Masahiro Yamamoto,Satoshi Uematsu,Ken J. Ishii,Osamu Takeuchi,Shizuo Akira, Journal of Experimental Medicine, Vol. 203, No. 7, p. 1795-1803, 2006/07/10
  • Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex, Takeshi Yoshimatsu,Daichi Kawaguchi,Koji Oishi,Kiyoshi Takeda,Shizuo Akira,Norihisa Masuyama,Yukiko Gotoh, Development, Vol. 133, No. 13, p. 2553-2563, 2006/07
  • Activation of smooth muscle and myenteric plexus cells of jejunum via toll-like receptor 4, C Rumio,D Besusso,F Arnaboldi,M Palazzo,S Selleri,S Gariboldi,S Akira,S Uematsu,P Bignami,Ceriani, V,S Menard,A Balsari, JOURNAL OF CELLULAR PHYSIOLOGY, WILEY-LISS, Vol. 208, No. 1, p. 47-54, 2006/07
  • Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha(3)beta(1), AK Behera,E Hildebrand,S Uematsu,S Akira,J Coburn,LT Hu, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 177, No. 1, p. 657-664, 2006/07
  • TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation, Anne Cottalorda,Claire Verschelde,Antoine Marcais,Martine Tomkowiak,Philippe Musette,Satoshi Uematsu,Shizuo Akira,Jacqueline Marvel,Nathalie Bonnefoy-Berard, EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-V C H VERLAG GMBH, Vol. 36, No. 7, p. 1684-1693, 2006/07
  • Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa, Samithamby Jeyaseelan,Scott K. Young,Masahiro Yamamoto,Patrick G. Arndt,Shizuo Akira,Jay K. Kolls,G. Scott Worthen, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 177, No. 1, p. 538-547, 2006/07
  • Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity, Fumihiko Takeshita,Toshiyuki Tanaka,Tomoko Matsuda,Miyuki Tozuka,Kouji Kobiyama,Sukumar Saha,Kiyohiko Matsui,Ken J. Ishii,Cevayir Coban,Shizuo Akira,Norihisa Ishii,Koichi Suzuki,Dennis M. Klinman,Kenii Okuda,Shin Sasaki, Journal of Virology, Vol. 80, No. 13, p. 6218-6224, 2006/07
  • IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses, Carola Schellack,Karin Prinz,Alena Egyed,Jörg H. Fritz,Barbara Wittmann,Michael Ginzler,Gabriele Swatosch,Wolfgang Zauner,Constantia Kast,Shizuo Akira,Alexander von Gabain,Michael Buschle,Karen Lingnau, Vaccine, Vol. 24, No. 26, p. 5461-5472, 2006/06/29
  • Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance, Mihai G. Netea,Leo A. B. Joosten,Eli Lewis,Dalan R. Jensen,Peter J. Voshol,Bart Jan Kullberg,Cees J. Tack,Han Van Krieken,Soo-Hyun Kim,Anton F. Stalenhoef,Fons A. Van De Loo,Ineke Verschueren,Leslie Pulawa,Shizuo Akira,Robert H. Eckel,Charles A. Dinarello,Wim Van Den Berg,Jos W. M. Van Der Meer, Nature Medicine, Vol. 12, No. 6, p. 650-656, 2006/06
  • Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation, Takeshi Miyatsuka,Hideaki Kaneto,Toshihiko Shiraiwa,Taka-Aki Matsuoka,Kaoru Yamamoto,Ken Kato,Yumiko Nakamura,Shizuo Akira,Kiyoshi Takeda,Yoshitaka Kajimoto,Yoshimitsu Yamasaki,Eric P. Sandgren,Yoshiya Kawaguchi,Christopher V. E. Wright,Yoshio Fujitani, Genes and Development, Vol. 20, No. 11, p. 1435-1440, 2006/06/01
  • Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment., Yoshinori Nagai,Karla P Garrett,Shoichiro Ohta,Uleng Bahrun,Taku Kouro,Shizuo Akira,Kiyoshi Takatsu,Paul W Kincade, Immunity, Vol. 24, No. 6, p. 801-12, 2006/06
  • Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1, Tatsuya Saitoh,Adrian Tun-Kyi,Akihide Ryo,Masahiro Yamamoto,Greg Finn,Takashi Fujita,Shizuo Akira,Naoki Yamamoto,Kun Ping Lu,Shoji Yamaoka, Nature Immunology, Vol. 7, No. 6, p. 598-605, 2006/06
  • [Innate immune recognition of viral infection]., Uematsu S,Akira S, Uirusu, Vol. 56, No. 1, p. 1-8, 2006/06
  • Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis., Noriko Takegahara,Hyota Takamatsu,Toshihiko Toyofuku,Tohru Tsujimura,Tatsusada Okuno,Kazunori Yukawa,Masayuki Mizui,Midori Yamamoto,Durbaka V R Prasad,Kazuhiro Suzuki,Masaru Ishii,Kenta Terai,Masayuki Moriya,Yuji Nakatsuji,Saburo Sakoda,Shintaro Sato,Shizuo Akira,Kiyoshi Takeda,Masanori Inui,Toshiyuki Takai,Masahito Ikawa,Masaru Okabe,Atsushi Kumanogoh,Hitoshi Kikutani, Nature cell biology, Vol. 8, No. 6, p. 615-22, 2006/06
  • C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation, Motoyoshi Endo,Masataka Mori,Shizuo Akira,Tomomi Gotoh, Journal of Immunology, Vol. 176, No. 10, p. 6245-6253, 2006/05/15
  • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses, Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken J. Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang Sung Koh,Caetano Reis E Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira, Nature, Vol. 441, No. 1, p. 101-105, 2006/05/04
  • "Endogenous adjuvant" activity of the RNA components of lupus auto antigens Sm/RNP and Ro 60, Kindra M. Kelly,Haoyang Zhuang,Dina C. Nacionales,Philip O. Scumpia,Robert Lyons,Jun Akaogi,Pui Lee,Bryan Williams,Masahiro Yamamoto,Shizuo Akira,Minoru Satoh,Westley H. Reeves, Arthritis and Rheumatism, Vol. 54, No. 5, p. 1557-1567, 2006/05
  • Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice, M Barrier,S Lacroix-Lamande,R Mancassola,GL Auray,N Bernardet,AM Chausse,S Uematsu,S Akira,F Laurent, JOURNAL OF INFECTIOUS DISEASES, OXFORD UNIV PRESS INC, Vol. 193, No. 10, p. 1400-1407, 2006/05
  • Toll-like receptors in antiviral immunity: more than just response, Andreas Jung,Shizuo Akira, FUTURE VIROLOGY, FUTURE MEDICINE LTD, Vol. 1, No. 3, p. 313-316, 2006/05
  • Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice, Kazunori Yukawa,Tetsuji Tanaka,Tao Bai,Li Li,Yuji Tsubota,Kyoko Owada-Makabe,Masanobu Maeda,Katsuaki Hoshino,Shizuo Akira,Hiroyuki Iso, International Journal of Molecular Medicine, Vol. 17, No. 5, p. 869-873, 2006/05
  • Induction of β-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2, Yasuyuki Sumikawa,Hideo Asada,Katsuaki Hoshino,Hiroaki Azukizawa,Ichiro Katayama,Shizuo Akira,Satoshi Itami, Microbes and Infection, Vol. 8, No. 6, p. 1513-1521, 2006/05
  • The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Daniel C. Rowe,Anne F. McGettrick,Eicke Latz,Brian G. Monks,Nicholas J. Gay,Masahiro Yamamoto,Shizuo Akira,Luke A. O'Neill,Katherine A. Fitzgerald,Douglas T. Golenbock, Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 16, p. 6299-6304, 2006/04/18
  • Cutting edge: Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA, Ken Takahashi,Taro Kawai,Himanshu Kumar,Shintaro Sato,Shin Yonehara,Shizuo Akira, Journal of Immunology, American Association of Immunologists, Vol. 176, No. 8, p. 4520-4524, 2006/04/15
  • IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9., Katsuaki Hoshino,Takahiro Sugiyama,Mitsuru Matsumoto,Takashi Tanaka,Masuyoshi Saito,Hiroaki Hemmi,Osamu Ohara,Shizuo Akira,Tsuneyasu Kaisho, Nature, Vol. 440, No. 7086, p. 949-53, 2006/04/13
  • TLR1- and TLR6-independent recognition of bacterial lipopeptides, Ute Buwitt-Beckmann,Holger Heine,Karl-Heinz Wiesmüller,Günther Jung,Roland Brock,Shizuo Akira,Artur J. Ulmer, Journal of Biological Chemistry, Vol. 281, No. 14, p. 9049-9057, 2006/04/07
  • Role of hepatic STAT3 in brain-insulin action on hepatic glucose production, Hiroshi Inoue,Wataru Ogawa,Akihiro Asakawa,Yasuo Okamoto,Akihiko Nishizawa,Michihiro Matsumoto,Kiyoshi Teshigawara,Yasushi Matsuki,Eijiro Watanabe,Ryuji Hiramatsu,Kenji Notohara,Koji Katayose,Hitoshi Okamura,C. Ronald Kahn,Tetsuo Noda,Kiyoshi Takeda,Shizuo Akira,Akio Inui,Masato Kasuga, Cell Metabolism, Vol. 3, No. 4, p. 267-275, 2006/04
  • IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis, Leilani L. Santos,Georgia P. Milenkovski,Pamela H. Hall,Michelle Leech,Laveena Sharma,Kiyoshi Takeda,Shizuo Akira,A. Richard Kitching,Eric F. Morand, Immunology and Cell Biology, Vol. 84, No. 2, p. 166-173, 2006/04
  • Essential role of I kappa B kinase alpha in thymic organogenesis required for the establishment of self-tolerance, Dan Kinoshita,Fumiko Hirota,Tsuneyasu Kaisho,Michiyuki Kasai,Keisuke Izumi,Yoshimi Bando,Yasuhiro Mouri,Akemi Matsushima,Shino Niki,Hongwei Han,Kiyotaka Oshikawa,Noriyuki Kuroda,Masahiko Maegawa,Minoru Irahara,Kiyoshi Takeda,Shizuo Akira,Mitsuru Matsumoto, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 176, No. 7, p. 3995-4002, 2006/04
  • TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-κB, Noriyuki Uemura,Taisuke Kajino,Hideki Sanjo,Shintaro Sato,Shizuo Akira,Kunihiro Matsumoto,Jun Ninomiya-Tsuji, Journal of Biological Chemistry, Vol. 281, No. 12, p. 7863-7872, 2006/03/24
  • Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines., Noriko Sato,Nobuyuki Kamada,Ryuta Muromoto,Taro Kawai,Kenji Sugiyama,Tadashi Watanabe,Seiyu Imoto,Yuichi Sekine,Norihiko Ohbayashi,Masato Ishida,Shizuo Akira,Tadashi Matsuda, Immunology letters, Vol. 103, No. 2, p. 127-34, 2006/03/15
  • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3, Thirumala-Devi Kanneganti,Nesrin Özören,Mathilde Body-Malapel,Amal Amer,Jong-Hwan Park,Luigi Franchi,Joel Whitfield,Winfried Barchet,Marco Colonna,Peter Vandenabeele,John Bertin,Anthony Coyle,Ethan P. Grant,Shizuo Akira,Gabriel Núñez, Nature, Nature Publishing Group, Vol. 440, No. 7081, p. 233-236, 2006/03/09
  • Antitumor effect of OK-432-derived DNA: One of the active constituents of OK-432, a streptococcal immunotherapeutic agent, Tetsuya Oshikawa,Masato Okamoto,Tomoyuki Tano,Akiko Sasai,Shin Kan,Yoichiro Moriya,Yoshiki Ryoma,Motoo Saito,Shizuo Akira,Mitsunobu Sato, Journal of Immunotherapy, Vol. 29, No. 2, p. 143-150, 2006/03
  • Differential inductions of TNF-α and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides, Nicolas Lapaque,Osamu Takeuchi,Fernando Corrales,Shizuo Akira,Ignacio Moriyon,Jonathan C. Howard,Jean Pierre Gorvel, Cellular Microbiology, Vol. 8, No. 3, p. 401-413, 2006/03
  • Regulation of cytosolic phospholipase A(2) activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor, S Suram,GD Brown,M Ghosh,S Gordon,R Loper,PR Taylor,S Akira,S Uematsu,DL Williams,CC Leslie, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 281, No. 9, p. 5506-5514, 2006/03
  • MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi, AK Behera,E Hildebrand,RT Bronson,G Perides,S Uematsu,S Akira,LT Hu, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 74, No. 3, p. 1462-1470, 2006/03
  • The role of Toll-like receptors in immune disorders, Satoshi Uematsu,Shizuo Akira, Expert Opinion on Biological Therapy, Vol. 6, No. 3, p. 203-214, 2006/03
  • Pathogen recognition and innate immunity, Shizuo Akira,Satoshi Uematsu,Osamu Takeuchi, Cell, Vol. 124, No. 4, p. 783-801, 2006/02/24
  • Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity, Troy Querec,Soumaya Bennouna,Sefik Alkan,Yasmina Laouar,Keith Gorden,Richard Flavell,Shizuo Akira,Rafi Ahmed,Bali Pulendran, Journal of Experimental Medicine, Vol. 203, No. 2, p. 413-424, 2006/02/20
  • Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway, Ping Zhu,Sung Hee Baek,Eliot M. Bourk,Kenneth A. Ohgi,Ivan Garcia-Bassets,Hideki Sanjo,Shizuo Akira,Paul F. Kotol,Christopher K. Glass,Michael G. Rosenfeld,David W. Rose, Cell, Vol. 124, No. 3, p. 615-629, 2006/02/10
  • The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through Toll-like receptor 2, Kazuto Kiura,Hideo Kataoka,Takashi Nakata,Takeshi Into,Motoaki Yasuda,Shizuo Akira,Nobuo Inoue,Ken-Ichiro Shibata, FEMS Immunology and Medical Microbiology, Vol. 46, No. 1, p. 78-84, 2006/02
  • Toll-like receptor 2 controls expansion and function of regulatory T cells, Roger P.M. Sutmuller,Martijn H.M.G.M. Den Brok,Matthijs Kramer,Erik J. Bennink,Liza W.J. Toonen,Bart-Jan Kullberg,Leo A. Joosten,Shizuo Akira,Mihai G. Netea,Gosse J. Adema, Journal of Clinical Investigation, Vol. 116, No. 2, p. 485-494, 2006/02/01
  • Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection, Hans Fischer,Masahiro Yamamoto,Shizuo Akira,Bruce Beutler,Catharina Svanborg, European Journal of Immunology, Vol. 36, No. 2, p. 267-277, 2006/02
  • Innate immune recognition of viral infection, Taro Kawai,Shizuo Akira, Nature Immunology, Vol. 7, No. 2, p. 131-137, 2006/02
  • Up-regulation of NOD1 and NOD2 through TLR4 and TNF-α in LPS-treated murine macrophages, Yuji Takahashi,Kazuto Isuzugawa,Yasunori Murase,Misa Imai,Shinya Yamamoto,Masateru Iizuka,Shizuo Akira,George M. Bahr,Ei-Ichi Momotani,Masatoshi Hori,Hiroshi Ozaki,Kazuhiko Imakawa, Journal of Veterinary Medical Science, Vol. 68, No. 5, p. 471-478, 2006
  • MyD88 signaling controls autoimmune myocarditis induction, René R. Marty,Stephan Dirnhofer,Nora Mauermann,Sacha Schweikert,Shizuo Akira,Lukas Hunziker,Josef M. Penninger,Urs Eriksson, Circulation, Vol. 113, No. 2, p. 258-265, 2006/01
  • Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO, Gerhard Wingender,Natalio Garbi,Beatrix Schumak,Frank Jüngerkes,Elmar Endl,Dagmar von Bubnoff,Julia Steitz,Jörg Striegler,Gerd Moldenhauer,Thomas Tüting,Antje Heit,Katharina M. Huster,Osamu Takikawa,Shizuo Akira,Dirk H. Busch,Hermann Wagner,Günter J. Hämmerling,Percy A. Knolle,Andreas Limmer, European Journal of Immunology, Vol. 36, No. 1, p. 12-20, 2006/01
  • BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway, Jun Wan,Wei Zhang,Liming Wu,Ting Bai,Mingjie Zhang,Kwok-Wai Lo,Yiu-Ioon Chui,Yan Cui,Qian Tao,Masahiro Yamamoto,Shizuo Akira,Zhenguo Wu, Molecular and Cellular Biology, Vol. 26, No. 2, p. 448-456, 2006/01
  • Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages, Yuichi Sekine,Taro Yumioka,Tetsuya Yamamoto,Ryuta Muromoto,Seiyu Imoto,Kenji Sugiyma,Kenji Oritani,Kazuya Shimoda,Mayu Minoguchi,Shizuo Akira,Akihiko Yoshimura,Tadashi Matsuda, Journal of Immunology, Vol. 176, No. 1, p. 380-389, 2006/01/01
  • MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice, KA Rogers,AB Rogers,BA Leav,A Sanchez,E Vannier,S Uematsu,S Akira,D Golenbock,HD Ward, INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, Vol. 74, No. 1, p. 549-556, 2006/01
  • A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA, Ken J. Ishii,Cevayir Coban,Hiroki Kato,Ken Takahashi,Yuichi Torii,Fumihiko Takeshita,Holger Ludwig,Gerd Sutter,Koichi Suzuki,Hiroaki Hemmi,Shintaro Sato,Masahiro Yamamoto,Satoshi Uematsu,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 1, p. 40-48, 2006/01
  • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8, Jörg Vollmer,Sibylle Tluk,Claudia Schmitz,Svetlana Hamm,Marion Jurk,Alexandra Forsbach,Shizuo Akira,Kindra M. Kelly,Westley H. Reeves,Stefan Bauer,Arthur M. Krieg, Journal of Experimental Medicine, Vol. 202, No. 11, p. 1575-1585, 2005/12/05
  • Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest, Rabindra N. Bhattacharjee,Kwon Sam Park,Satoshi Uematsu,Kazuhisa Okada,Katsuaki Hoshino,Kiyoshi Takeda,Osamu Takeuchi,Shizuo Akira,Tetsuya Iida,Takeshi Honda, FEBS Letters, Vol. 579, No. 29, p. 6604-6610, 2005/12/05
  • Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite, Anuradha Poonepalli,Lakshmidevi Balakrishnan,Aik Kia Khaw,Grace Kah Mun Low,Manikandan Jayapal,Rabindra N. Bhattacharjee,Shizuo Akira,Adayabalam S. Balajee,M. Prakash Hande, Cancer Research, Vol. 65, No. 23, p. 10977-10983, 2005/12/01
  • Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli, Samithamby Jeyaseelan,Rizwan Manzer,Scott K. Young,Masahiro Yamamoto,Shizuo Akira,Robert J. Mason,G. Scott Worthen, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 11, p. 7484-7495, 2005/12/01
  • Physical and functional interactions between STAT3 and ZIP kinase., Sato N,Kawai T,Sugiyama K,Muromoto R,Imoto S,Sekine Y,Ishida M,Akira S,Matsuda T, International immunology, 12, Vol. 17, No. 12, p. 1543-1552, 2005/12
  • Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT, Akihiro Kimura,Tetsuji Naka,Tatsushi Muta,Osamu Takeuchi,Shizuo Akira,Ichiro Kawase,Tadamitsu Kishimoto, Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 47, p. 17089-17094, 2005/11/22
  • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation, Yasutaka Okabe,Kohki Kawane,Shizuo Akira,Tadatsugu Taniguchi,Shigekazu Nagata, Journal of Experimental Medicine, Vol. 202, No. 10, p. 1333-1339, 2005/11/21
  • Innate immune recognition of nucleic acids: Beyond toll-like receptors, Ken J. Ishii,Shizuo Akira, International Journal of Cancer, Vol. 117, No. 4, p. 517-523, 2005/11/20
  • TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo, Jae-Hyuck Shim,Changchun Xiao,Amber E. Paschal,Shannon T. Bailey,Ping Rao,Matthew S. Hayden,Ki-Young Lee,Crystal Bussey,Michael Steckel,Nobuyuki Tanaka,Gen Yamada,Shizuo Akira,Kunihiro Matsumoto,Sankar Ghosh, Genes and Development, Vol. 19, No. 22, p. 2668-2681, 2005/11/15
  • MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-α release and initiation of immune responses in vivo, Thomas Delale,André Paquin,Carine Asselin-Paturel,Marc Dalod,Géraldine Brizard,Elizabeth E. M. Bates,Philippe Kastner,Susan Chan,Shizuo Akira,Alain Vicari,Christine A. Biron,Giorgio Trinchieri,Francine Brière, Journal of Immunology, Vol. 175, No. 10, p. 6723-6732, 2005/11/15
  • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement, Christina M. Lau,Courtney Broughton,Abigail S. Tabor,Shizuo Akira,Richard A. Flavell,Mark J. Mamula,Sean R. Christensen,Mark J. Shlomchik,Gregory A. Viglianti,Ian R. Rifkin,Ann Marshak-Rothstein, Journal of Experimental Medicine, Vol. 202, No. 9, p. 1171-1177, 2005/11/07
  • The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung, Catharina W. Wieland,Sandrine Florquin,Nico A. Maris,Kasper Hoebe,Bruce Beutler,Kiyoshi Takeda,Shizuo Akira,Tom Van Der Poll, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 9, p. 6042-6049, 2005/11/01
  • Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice, Sanae Haga,Wataru Ogawa,Hiroshi Inoue,Keita Terui,Tetsuya Ogino,Rumi Igarashi,Kiyoshi Takeda,Shizuo Akira,Shin Enosawa,Hiroyuki Furukawa,Satoru Todo,Michitaka Ozaki, Journal of Hepatology, Vol. 43, No. 5, p. 799-807, 2005/11
  • Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I, H. Kato,T. Kawai,S. Uematsu,O. Takeuchi,S. Akira, International Congress Series, Vol. 1285, p. 10-14, 2005/11
  • Manifold mechanisms of toll-like receptor-ligand recognition, Ken J. Ishii,Cevayir Coban,Shizuo Akira, Journal of Clinical Immunology, Vol. 25, No. 6, p. 511-521, 2005/11
  • Essential function for the kinase TAK1 in innate and adaptive immune responses, Shintaro Sato,Hideki Sanjo,Kiyoshi Takeda,Jun Ninomiya-Tsuji,Masahiro Yamamoto,Taro Kawai,Kunihiro Matsumoto,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 6, No. 11, p. 1087-1095, 2005/11
  • The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I, Simon Rothenfusser,Nadege Goutagny,Gary DiPerna,Mei Gong,Brian G. Monks,Annett Schoenemeyer,Masahiro Yamamoto,Shizuo Akira,Katherine A. Fitzgerald, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 8, p. 5260-5268, 2005/10/15
  • CXCL13 is an arrest chemokine for B cells in high endothelial venules., Naotoshi Kanemitsu,Yukihiko Ebisuno,Toshiyuki Tanaka,Kazuhiro Otani,Haruko Hayasaka,Tsuneyasu Kaisho,Shizuo Akira,Koko Katagiri,Tatsuo Kinashi,Naoya Fujita,Takashi Tsuruo,Masayuki Miyasaka, Blood, Vol. 106, No. 8, p. 2613-8, 2005/10/15
  • Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of coxsackievirus B3-induced myocarditis and influences type I interferon production, Koichi Fuse,Grace Chan,Youan Liu,Patrick Gudgeon,Mansoor Husain,Manyin Chen,Wen-Chen Yeh,Shizuo Akira,Peter P. Liu, Circulation, Vol. 112, No. 15, p. 2276-2285, 2005/10/11
  • Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-γ-induced apoptosis in primary pancreatic β-cells, Joanne Rasschaert,Laurence Ladrière,Maryse Urbain,Zeynep Dogusan,Bitty Katabua,Shintaro Sato,Shizuo Akira,Conny Gysemans,Chantal Mathieu,Decio L. Eizirik, Journal of Biological Chemistry, Vol. 280, No. 40, p. 33984-33991, 2005/10/07
  • Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney, Jaklien C. Leemans,Geurt Stokman,Nike Claessen,Kasper M. Rouschop,Gwendoline J. D. Teske,Carsten J. Kirschning,Shizuo Akira,Tom Van Der Poll,Jan J. Weening,Sandrine Florquin, Journal of Clinical Investigation, Vol. 115, No. 10, p. 2894-2903, 2005/10
  • Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus, FJ Barrat,T Meeker,J Gregorio,JH Chan,S Uematsu,S Akira,B Chang,O Duramad,RL Coffman, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 202, No. 8, p. 1131-1139, 2005/10
  • Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum, M Baratin,S Roetynck,C Lepolard,C Falk,S Sawadogo,S Uematsu,S Akira,B Ryffel,JG Tiraby,L Alexopoulou,CJ Kirschning,J Gysin,E Vivier,S Ugolini, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 102, No. 41, p. 14747-14752, 2005/10
  • IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction, Taro Kawai,Ken Takahashi,Shintaro Sato,Cevayir Coban,Himanshu Kumar,Hiroki Kato,Ken J. Ishii,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 6, No. 10, p. 981-988, 2005/10
  • Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9, Li-Yun Huang,Ken J. Ishii,Shizuo Akira,Julio Aliberti,Basil Golding, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 6, p. 3964-3970, 2005/09/15
  • Stat3 in resident macrophages as a repressor protein of inflammatory response, Akihiro Matsukawa,Shinji Kudo,Takako Maeda,Kousuke Numata,Hiroyuki Watanabe,Kiyoshi Takeda,Shizuo Akira,Takaaki Ito, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 5, p. 3354-3359, 2005/09/01
  • Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex, Hyung S. Youn,Joo Y. Lee,Katherine A. Fitzgerald,Howard A. Young,Shizuo Akira,Daniel H. Hwang, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 5, p. 3339-3346, 2005/09/01
  • Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity, Mitsutoshi Yoneyama,Mika Kikuchi,Kanae Matsumoto,Tadaatsu Imaizumi,Makoto Miyagishi,Kazunari Taira,Eileen Foy,Yueh-Ming Loo,Michael Gale Jr.,Shizuo Akira,Shin Yonehara,Atsushi Kato,Takashi Fujita, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 5, p. 2851-2858, 2005/09/01
  • Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis., Alla Amcheslavsky,Hiroaki Hemmi,Shizuo Akira,Zvi Bar-Shavit, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 20, No. 9, p. 1692-9, 2005/09
  • Involvement of Toll-like receptor 2 in experimental invasive pulmonary Aspergillosis, Viviane Balloy,Mustapha Si-Tahar,Osamu Takeuchi,Bruno Philippe,Marie Anne Nahori,Myriam Tanguy,Michel Huerre,Shizuo Akira,Jean Paul Latgé,Michel Chignard, Infection and Immunity, Vol. 73, No. 9, p. 5420-5425, 2005/09
  • Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus, RN Bhattacharjee,KS Park,K Okada,Y Kumagai,S Uematsu,O Takeuchi,S Akira,T Iida,T Honda, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 335, No. 2, p. 328-334, 2005/09
  • Microglia-specific expression of microsomal prostaglandin E-2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E-2 production, Y Ikeda-Matsuo,Y Ikegaya,N Matsuki,S Uematsu,S Akira,Y Sasaki, JOURNAL OF NEUROCHEMISTRY, BLACKWELL PUBLISHING, Vol. 94, No. 6, p. 1546-1558, 2005/09
  • MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus, David S. Weiss,Kiyoshi Takeda,Shizuo Akira,Arturo Zychlinsky,Edgardo Moreno, Infection and Immunity, Vol. 73, No. 8, p. 5137-5143, 2005/08
  • Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70, Hye-Seong Mun,Fumie Aosai,Kazumi Norose,Lian-Xun Piao,Hao Fang,Shizuo Akira,Akihiko Yano, Infection and Immunity, Vol. 73, No. 8, p. 4634-4642, 2005/08
  • Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1α, and TNF-α through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts, Shuhua Yang,Naoyuki Takahashi,Teruhito Yamashita,Nobuaki Sato,Masahiro Takahashi,Makio Mogi,Takashi Uematsu,Yasuhiro Kobayashi,Yuko Nakamichi,Kiyoshi Takeda,Shizuo Akira,Haruhiko Takada,Nobuyuki Udagawa,Kiyofumi Furusawa, Journal of Immunology, Vol. 175, No. 3, p. 1956-1964, 2005/08/01
  • Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway, WJ de Jonge,EP van der Zanden,F O The,MF Bijlsma,DJ van Westerloo,RJ Bennink,HR Berthoud,S Uematsu,S Akira,RM van den Wijngaard,GE Boeckxstaens, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 8, p. 844-851, 2005/08
  • Pathogen recognition with Toll-like receptors, Taro Kawai,Shizuo Akira, Current Opinion in Immunology, Vol. 17, No. 4, p. 338-344, 2005/08
  • CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection., Ken J Ishii,Shuichi Ito,Tomohiko Tamura,Hiroaki Hemmi,Jacqueline Conover,Keiko Ozato,Shizuo Akira,Dennis M Klinman, European journal of immunology, Vol. 35, No. 8, p. 2397-405, 2005/08
  • TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF, Fumihiko Takeshita,Ken J. Ishii,Kouji Kobiyama,Yoshitsugu Kojima,Cevayir Coban,Shin Sasaki,Norihisa Ishii,Dennis M. Klinman,Kenji Okuda,Shizuo Akira,Koichi Suzuki, European Journal of Immunology, Vol. 35, No. 8, p. 2477-2485, 2005/08
  • Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus, Sean R. Christensen,Michael Kashgarian,Lena Alexopoulou,Richard A. Flavell,Shizuo Akira,Mark J. Shlomchik, Journal of Experimental Medicine, Vol. 202, No. 2, p. 321-331, 2005/07/18
  • Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis, Yuko Kato,Atsushi Iwama,Yuko Tadokoro,Kazuya Shimoda,Mayu Minoguchi,Shizuo Akira,Minoru Tanaka,Atsushi Miyajima,Toshio Kitamura,Hiromitsu Nakauchi, Journal of Experimental Medicine, Vol. 202, No. 1, p. 169-179, 2005/07/04
  • House dust extracts elicit Toll-like receptor-dependent dendritic cell responses, Jared Boasen,Dugald Chisholm,Lev Lebet,Shizuo Akira,Anthony A. Horner, Journal of Allergy and Clinical Immunology, Vol. 116, No. 1, p. 185-191, 2005/07
  • Cell type-specific involvement of RIG-I in antiviral response, Hiroki Kato,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Tohru Tsujimura,Kiyoshi Takeda,Takashi Fujita,Osamu Takeuchi,Shizuo Akira, Immunity, Vol. 23, No. 1, p. 19-28, 2005/07
  • The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes, Yoshinori Nagai,Toshihiko Kobayashi,Yuji Motoi,Kohtaroh Ishiguro,Sachiko Akashi,Shin-Ichiroh Saitoh,Yutaka Kusumoto,Tsuneyasu Kaisho,Shizuo Akira,Mitsuru Matsumoto,Kiyoshi Takatsu,Kensuke Miyake, Journal of Immunology, American Association of Immunologists, Vol. 174, No. 11, p. 7043-7049, 2005/06/01
  • Role of TLR in B cell development: Signaling through TLR4 promotes B cell maturation and is inhibited by TLR2, Elize A. Hayashi,Shizuo Akira,Alberto Nobrega, Journal of Immunology, American Association of Immunologists, Vol. 174, No. 11, p. 6639-6647, 2005/06/01
  • Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer, RC Yang,CM Wheeler,XJ Chen,S Uematsu,K Takeda,S Akira,DV Pastrana,RP Viscidi,RBS Roden, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 79, No. 11, p. 6741-6750, 2005/06
  • B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88, RC Yang,FM Murillo,MJ Delannoy,RL Blosser,WH Yutzy,S Uematsu,K Takeda,S Akira,RP Viscidi,RBS Roden, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 174, No. 12, p. 7912-7919, 2005/06
  • Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: Monoacylated MDP confers TLR2/TLR4 activation, J Uehori,K Fukase,T Akazawa,S Uematsu,S Akira,K Funami,M Shingai,M Matsumoto,Azuma, I,K Toyoshima,S Kusumoto,T Seya, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 174, No. 11, p. 7096-7103, 2005/06
  • TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway, Satoshi Kishida,Hideki Sanjo,Shizuo Akira,Kunihiro Matsumoto,Jun Ninomiya-Tsuji, Genes to Cells, Vol. 10, No. 5, p. 447-454, 2005/05
  • Role of lipoteichoic acid in the phagocyte response to group B Streptococcus, P Henneke,S Morath,S Uematsu,S Weichert,M Pfitzenmaier,O Takeuchi,A Muller,C Poyart,S Akira,R Berner,G Teti,A Geyer,T Hartung,P Trieu-Cuot,DL Kasper,DT Golenbock, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 174, No. 10, p. 6449-6455, 2005/05
  • Mechanisms of innate immune responses mediated by Toll-like receptors, Masahiro Yamamoto,Shizuo Akira, Clinical and Applied Immunology Reviews, Vol. 5, No. 3, p. 167-183, 2005/05
  • A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages, Toshihiko Suzuki,Kenji Nakanishi,Hiroko Tsutsui,Hiroki Iwai,Shizuo Akira,Naohiro Inohara,Mathias Chamaillard,Gabriel Nuñez,Chihiro Sasakawa, Journal of Biological Chemistry, Vol. 280, No. 14, p. 14042-14050, 2005/04/08
  • PI3K integrates the action of insulin and leptin on hypothalamic neurons, Allison Wanting Xu,Christopher B. Kaelin,Kiyoshi Takeda,Shizuo Akira,Michael W. Schwartz,Gregory S. Barsh, Journal of Clinical Investigation, Vol. 115, No. 4, p. 951-958, 2005/04
  • Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling, Yasuyuki Asai,Masahito Hashimoto,Hansel M. Fletcher,Kensuke Miyake,Shizuo Akira,Tomohiko Ogawa, Infection and Immunity, Vol. 73, No. 4, p. 2157-2163, 2005/04
  • Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes, Christoph Kalis,Marina Gumenscheimer,Nikolaus Freudenberg,Sandrine Tchaptchet,György Fejer,Antje Heit,Shizuo Akira,Chris Galanos,Marina A. Freudenberg, Journal of Immunology, American Association of Immunologists, Vol. 174, No. 7, p. 4295-4300, 2005/04/01
  • Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKε, Adrien Breiman,Nathalie Grandvaux,Rongtuan Lin,Catherine Ottone,Shizuo Akira,Mitsutoshi Yoneyama,Takashi Fujita,John Hiscott,Eliane F. Meurs, Journal of Virology, Vol. 79, No. 7, p. 3969-3978, 2005/04
  • A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice, Hiroyuki Yoshitomi,Noriko Sakaguchi,Katsuya Kobayashi,Gordon D. Brown,Tomoyuki Tagami,Toshiko Sakihama,Keiji Hirota,Satoshi Tanaka,Takashi Nomura,Ichiro Miki,Siamon Gordon,Shizuo Akira,Takashi Nakamura,Shimon Sakaguchi, Journal of Experimental Medicine, Vol. 201, No. 6, p. 949-960, 2005/03/21
  • Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction, Satoshi Uematsu,Shintaro Sato,Masahiro Yamamoto,Tomonori Hirotani,Hiroki Kato,Fumihiko Takeshita,Michiyuki Matsuda,Cevayir Coban,Ken J. Ishii,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Journal of Experimental Medicine, Vol. 201, No. 6, p. 915-923, 2005/03/21
  • The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria, Tomonori Hirotani,Pui Y. Lee,Hirotaka Kuwata,Masahiro Yamamoto,Makoto Matsumoto,Ichiro Kawase,Shizuo Akira,Kiyoshi Takeda, Journal of Immunology, Vol. 174, No. 6, p. 3650-3657, 2005/03/15
  • Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β, Tomonori Hirotani,Masahiro Yamamoto,Yutaro Kumagai,Satoshi Uematsu,Ichiro Kawase,Osamu Takeuchi,Shizuo Akira, Biochemical and Biophysical Research Communications, Vol. 328, No. 2, p. 383-392, 2005/03/11
  • Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration, Ekihiro Seki,Hiroko Tsutsui,Yuji Iimuro,Tetsuji Naka,Gakuhei Son,Shizuo Akira,Tadamitsu Kishimoto,Kenji Nakanishi,Jiro Fujimoto, Hepatology, Vol. 41, No. 3, p. 443-450, 2005/03
  • Induction of proinflammatory responses in macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum - Cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity, G Krishnegowda,AM Hajjar,JZ Zhu,EJ Douglass,S Uematsu,S Akira,AS Woods,DC Gowda, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 280, No. 9, p. 8606-8616, 2005/03
  • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7, Hornung, V,M Guenthner-Biller,C Bourquin,A Ablasser,M Schlee,S Uematsu,A Noronha,M Manoharan,S Akira,A de Fougerolles,S Endres,G Hartmann, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 11, No. 3, p. 263-270, 2005/03
  • Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus., Takayuki Abe,Hiroaki Hemmi,Hironobu Miyamoto,Kohji Moriishi,Shinichi Tamura,Hiroshi Takaku,Shizuo Akira,Yoshiharu Matsuura, Journal of virology, Vol. 79, No. 5, p. 2847-58, 2005/03
  • Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice., Kumanogoh A,Shikina T,Suzuki K,Uematsu S,Yukawa K,Kashiwamura S,Tsutsui H,Yamamoto M,Takamatsu H,Ko-Mitamura EP,Takegahara N,Marukawa S,Ishida I,Morishita H,Prasad DV,Tamura M,Mizui M,Toyofuku T,Akira S,Takeda K,Okabe M,Kikutani H, Immunity, Vol. 22, No. 3, p. 305-316, 2005/03
  • Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus, Loïc Guillot,Ronan Le Goffic,Sarah Bloch,Nicolas Escriou,Shizuo Akira,Michel Chignard,Mustapha Si-Tahar, Journal of Biological Chemistry, Vol. 280, No. 7, p. 5571-5580, 2005/02/18
  • Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism, Marcus D. Säemann,Thomas Weichhart,Maximilian Zeyda,Günther Staffler,Michael Schunn,Karl M. Stuhlmeier,Yuri Sobanov,Thomas M. Stulnig,Shizuo Akira,Alexander Von Gabain,Uwe Von Ahsen,Walter H. Hörl,Gerhard J. Zlabinger, Journal of Clinical Investigation, Vol. 115, No. 2, p. 468-475, 2005/02
  • The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms, Siegfried Hapfelmeier,Bärbel Stecher,Manja Barthel,Marcus Kremer,Andreas J. Müller,Mathias Heikenwalder,Thomas Stallmach,Michael Hensel,Klaus Pfeffer,Shizuo Akira,Wolf-Dietrich Hardt, Journal of Immunology, American Association of Immunologists, Vol. 174, No. 3, p. 1675-1685, 2005/02/01
  • Spontaneous ocular surface inflammation and goblet cell disappearance in IκBζ gene-disrupted mice, Mayumi Ueta,Junji Hamuro,Masahiro Yamamoto,Kazuhiro Kaseda,Shizuo Akira,Shigeru Kinoshita, Investigative Ophthalmology and Visual Science, Vol. 46, No. 2, p. 579-588, 2005/02
  • Roles of Stat3 and ERK in G-CSF signaling, Kenjirou Kamezaki,Kazuya Shimoda,Akihiko Numata,Takashi Haro,Haruko Kakumitsu,Masumi Yoshie,Masahiro Yamamoto,Kiyoshi Takeda,Tadashi Matsuda,Shizuo Akira,Katsuhiro Ogawa,Mine Harada, Stem Cells, Vol. 23, No. 2, p. 252-263, 2005/02
  • Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease, KS Lang,M Recher,T Junt,AA Navarini,NL Harris,S Freigang,B Odermatt,C Conrad,LM Ittner,S Bauer,SA Luther,S Uematsu,S Akira,H Hengartner,RM Zinkernagel, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 11, No. 2, p. 138-145, 2005/02
  • A20 is a negative regulator of IFN regulatory factor 3 signaling, Tatsuya Saitoh,Masahiro Yamamoto,Makoto Miyagishi,Kazunari Taira,Makoto Nakanishi,Takashi Fujita,Shizuo Akira,Naoki Yamamoto,Shoji Yamaoka, Journal of Immunology, American Association of Immunologists, Vol. 174, No. 3, p. 1507-1512, 2005/02/01
  • IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment, A. Richard Kitching,Amanda L. Turner,Gabrielle R. A. Wilson,Timothy Semple,Dragana Odobasic,Jennifer R. Timoshanko,Kim M. O'Sullivan,Peter G. Tipping,Kiyoshi Takeda,Shizuo Akira,Stephen R. Holdsworth, Journal of the American Society of Nephrology, Vol. 16, No. 7, p. 2023-2033, 2005
  • MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis, Akihiro Araki,Takanori Kanai,Takahiro Ishikura,Shin Makita,Koji Uraushihara,Ryoichi Iiyama,Teruji Totsuka,Kiyoshi Takeda,Shizuo Akira,Mamoru Watanabe, Journal of Gastroenterology, Vol. 40, No. 1, p. 16-23, 2005/01
  • Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus, Koenraad F. Van Der Sluijs,Leontine J. R. Van Elden,Ramon Arens,Monique Nijhuis,Rob Schuurman,Sandrine Florquin,Joan Kwakkel,Shizuo Akira,Henk M. Jansen,René Lutter,Tom Van Der Polls, Immunology, Vol. 114, No. 1, p. 112-120, 2005/01
  • Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1, Daniel S. Mansur,Erna G. Kroon,Maurício L. Nogueira,Rosa M. E. Arantes,Soraia C. O. Rodrigues,Shizuo Akira,Ricardo T. Gazzinelli,Marco A. Campos, American Journal of Pathology, American Society for Investigative Pathology Inc., Vol. 166, No. 5, p. 1419-1426, 2005
  • Regulation of Id2 expression by CCAAT/enhancer binding protein β, Kazuhiro Karaya,Seiichi Mori,Hisashi Kimoto,Yoko Shima,Yoshihito Tsuji,Hisanori Kurooka,Shizuo Akira,Yoshifumi Yokota, Nucleic Acids Research, Vol. 33, No. 6, p. 1924-1934, 2005
  • Toll-like receptor 6-independent signaling by diacylated lipopeptides, Ute Buwitt-Beckmann,Holger Heine,Karl-Heinz Wiesmüller,Günther Jung,Roland Brock,Shizuo Akira,Artur J. Ulmer, European Journal of Immunology, Vol. 35, No. 1, p. 282-289, 2005/01
  • Differential roles of toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila, Morikazu Akamine,Futoshi Higa,Noriko Arakaki,Kazuyoshi Kawakami,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito, Infection and Immunity, Vol. 73, No. 1, p. 352-361, 2005/01
  • Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation, Yumiko Oishi,Ichiro Manabe,Kazuyuki Tobe,Kensuke Tsushima,Takayuki Shindo,Katsuhito Fujiu,Go Nishimura,Koji Maemura,Toshimasa Yamauchi,Naoto Kubota,Ryo Suzuki,Toshio Kitamura,Shizuo Akira,Takashi Kadowaki,Ryozo Nagai, Cell Metabolism, Vol. 1, No. 1, p. 27-39, 2005/01
  • TLR signalling and the function of dendritic cells., Hiroaki Hemmi,Shizuo Akira, Chemical immunology and allergy, Vol. 86, p. 120-135, 2005
  • TIR domain-containing adaptors regulate TLR signaling pathways, Masahiro Yamamoto,Shizuo Akira, Advances in Experimental Medicine and Biology, Vol. 560, p. 1-9, 2005
  • The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy., Yukawa K,Kishino M,Hoshino K,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Bai T,Tanaka T,Ueyama T,Ichinose M,Takeda K,Akira S,Maeda M, International journal of molecular medicine, Vol. 15, No. 1, p. 73-78, 2005
  • Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy., Yukawa K,Hoshino K,Kishino M,Tsubota Y,Owada-Makabe K,Maeda M,Bai T,Tanaka T,Akira S, International journal of molecular medicine, Vol. 16, No. 3, p. 389-393, 2005
  • Osteoclast differentiation is impaired in the absence of inhibitor of κB kinase α, Michelle L. Chaisson,Daniel G. Branstetter,Jonathan M. Derry,Allison P. Armstrong,Mark E. Tometsko,Kiyoshi Takeda,Shizuo Akira,William C. Dougall, Journal of Biological Chemistry, Vol. 279, No. 52, p. 54841-54848, 2004/12/24
  • Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron, Trude H. Flo,Kelly D. Smith,Shintaro Sato,David J. Rodriguez,Margaret A. Holmes,Roland K. Strong,Shizuo Akira,Alan Aderem, Nature, Vol. 432, No. 7019, p. 917-921, 2004/12/16
  • IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism, Silvia Stockinger,Benjamin Reutterer,Barbara Schaljo,Carola Schellack,Sylvia Brunner,Tilo Materna,Masahiro Yamamoto,Shizuo Akira,Tadatsugu Taniguchi,Peter J. Murray,Mathias Müller,Thomas Decker, Journal of Immunology, American Association of Immunologists, Vol. 173, No. 12, p. 7416-7425, 2004/12/15
  • Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart, Pascal Knuefermann,Yasushi Sakata,J. Scott Baker,Chien Hua Huang,Kenichi Sekiguchi,Hordur S. Hardarson,Osamu Takeuchi,Shizuo Akira,Jesus G. Vallejo, Circulation, Vol. 110, No. 24, p. 3693-3698, 2004/12/14
  • Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity, Yoshinori Suzuki,Daiko Wakita,Kenji Chamoto,Yoshinori Narita,Takemasa Tsuji,Tsuguhide Takeshima,Hiroshi Gyobu,You Kawarada,Satoshi Kondo,Shizuo Akira,Hiroyuki Katoh,Hiroaki Ikeda,Takashi Nishimura, Cancer Research, Vol. 64, No. 23, p. 8754-8760, 2004/12/01
  • Bacterial endotoxin induces IL-20 expression in the glial cells, Toru Hosoi,Sachiyo Wada,Sawako Suzuki,Yasunobu Okuma,Shizuo Akira,Tadashi Matsuda,Yasuyuki Nomura, Molecular Brain Research, Vol. 130, No. 1-2, p. 23-29, 2004/11/04
  • Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 parasite control, Anna Vossenkämper,Daniela Struck,Cosme Alvarado-Esquivel,Tobias Went,Kioyshi Takeda,Shizuo Akira,Klaus Pfeffer,Gottfried Alber,Matthias Lochner,Irmgard Förster,Oliver Liesenfeld, European Journal of Immunology, Vol. 34, No. 11, p. 3197-3207, 2004/11
  • Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi, Ana-Carolina Oliveira,Jaqueline R. Peixoto,Luciana B. De Arrada,Marco A. Campos,Ricardo T. Gazzinelli,Douglas T. Golenbock,Shizuo Akira,José O. Previato,Lúcia Mendonça-Previato,Alberto Nobrega,Maria Bellio, Journal of Immunology, American Association of Immunologists, Vol. 173, No. 9, p. 5688-5696, 2004/11/01
  • ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules, Masatatsu Yamamoto,Katsuyuki Yaginuma,Hiroko Tsutsui,Junji Sagara,Xin Guan,Ekihiro Seki,Koubun Yasuda,Masahiro Yamamoto,Shizuo Akira,Kenji Nakanishi,Tetsuo Noda,Shun'ichiro Taniguchi, Genes to Cells, Vol. 9, No. 11, p. 1055-1067, 2004/11
  • Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice, Delphine M. Nicolle,Xavier Pichon,André Bouchot,Isabelle Maillet,François Erard,Shizuo Akira,Bernhard Ryffel,Valérie F. J. Quesniaux, Laboratory Investigation, Vol. 84, No. 10, p. 1305-1321, 2004/10
  • Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice, Chikara Nakasone,Kazuyoshi Kawakami,Tomoaki Hoshino,Yusuke Kawase,Koichi Yokota,Kohichiro Yoshino,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito, Infection and Immunity, Vol. 72, No. 10, p. 6176-6180, 2004/10
  • Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88, RC Yang,FM Murillo,HM Cui,R Blosser,S Uematsu,K Takeda,S Akira,RP Viscidi,RBS Roden, JOURNAL OF VIROLOGY, AMER SOC MICROBIOLOGY, Vol. 78, No. 20, p. 11152-11160, 2004/10
  • Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity., TenOever BR,Sharma S,Zou W,Sun Q,Grandvaux N,Julkunen I,Hemmi H,Yamamoto M,Akira S,Yeh WC,Lin R,Hiscott J, <i><b> J Virol.</b></i>, Vol. 78, No. 19, p. 10636-10649, 2004/10
  • Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6, Taro Kawai,Shintaro Sato,Ken J. Ishii,Cevayir Coban,Hiroaki Hemmi,Masahiro Yamamoto,Kenta Terai,Michiyuki Matsuda,Jun Ichiro Inoue,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 5, No. 10, p. 1061-1068, 2004/10
  • Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice, S Hikoso,O Yamaguchi,Y Higuchi,S Hirotani,T Takeda,K Kashiwase,T Watanabe,M Taniike,Tsujimoto, I,M Asahi,Y Matsumura,K Nishida,H Nakajima,S Akira,M Hori,K Otsu, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 110, No. 17, p. 2631-2637, 2004/10
  • Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88, Nadra Nilsen,Unni Nonstad,Naseema Khan,Cathrine F. Knetter,Shizuo Akira,Anders Sundan,Terje Espevik,Egil Lien, Journal of Biological Chemistry, Vol. 279, No. 38, p. 39727-39735, 2004/09/17
  • CCAAT/enhancer-binding protein δ contributes to myofibroblast transdifferentiation and renal disease progression, Masanobu Takeji,Noritaka Kawada,Toshiki Moriyama,Katsuyuki Nagatoya,Susumu Oseto,Shizuo Akira,Masatsugu Hori,Enyu Imai,Takeshi Miwa, Journal of the American Society of Nephrology, Vol. 15, No. 9, p. 2383-2390, 2004/09
  • Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning, Robert M. Smith,Naushaad Suleman,Lydia Lacerda,Lionel H. Opie,Shizuo Akira,Kenneth R. Chien,Michael N. Sack, Cardiovascular Research, Vol. 63, No. 4, p. 611-616, 2004/09/01
  • IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition, S Jang,S Uematsu,S Akira,P Salgame, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 173, No. 5, p. 3392-3397, 2004/09
  • MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1 alpha, N Sato,N Takahashi,K Suda,M Nakamura,M Yimaki,T Ninomiya,Y Kobayashi,H Takada,K Shibata,M Yamamoto,K Takeda,S Akira,T Noguchi,N Udagawa, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 200, No. 5, p. 601-611, 2004/09
  • Abnormal retinal vascular development in IL-18 knockout mice, Hong Qiao,Koh-Hei Sonoda,Yukio Sassa,Toshio Hisatomi,Hiroshi Yoshikawa,Yasuhiro Ikeda,Toshinori Murata,Shizuo Akira,Tatsuro Ishibashi, Laboratory Investigation, Vol. 84, No. 8, p. 973-980, 2004/08
  • Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation, Masato Okamoto,Sachiko Furuichi,Yasuhiko Nishioka,Tetsuya Oshikawa,Tomoyuki Tano,Sharif Uddin Ahmed,Kiyoshi Takeda,Shizuo Akira,Yoshiki Ryoma,Yoichiro Moriya,Motoo Saito,Saburo Sone,Mitsunobu Sato, Cancer Research, Vol. 64, No. 15, p. 5461-5470, 2004/08/01
  • MyD88 plays a unique role in host defense but not arthritis development in lyme disease, Devin D. Bolz,Rhianna S. Sundsbak,Ying Ma,Shizuo Akira,Carsten J. Kirschning,James F. Zachary,John H. Weis,Janis J. Weis, Journal of Immunology, American Association of Immunologists, Vol. 173, No. 3, p. 2003-2010, 2004/08/01
  • Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1, D Kamei,K Yamakawa,Y Takegoshi,M Mikami-Nakanishi,Y Nakatani,S Oh-ishi,H Yasui,Y Azuma,N Hirasawa,K Ohuchi,H Kawaguchi,Y Ishikawa,T Ishii,S Uematsu,S Akira,M Murakami,Kudo, I, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 279, No. 32, p. 33684-33695, 2004/08
  • Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations, RC Yang,FM Murillo,KY Lin,WH Yutzy,S Uematsu,K Takeda,S Akira,RP Viscidi,RBS Roden, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 173, No. 4, p. 2624-2631, 2004/08
  • Lack of toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E, Kathrin S. Michelsen,Michelle H. Wong,Prediman K. Shah,Wenxuan Zhang,Juliana Yano,Terence M. Doherty,Shizuo Akira,Tripathi B. Rajavashisth,Moshe Arditi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 29, p. 10679-10684, 2004/07/20
  • Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice., Shin-Ichi Gorogawa,Yoshio Fujitani,Hideaki Kaneto,Yoji Hazama,Hirotaka Watada,Yasuhide Miyamoto,Kiyoshi Takeda,Shizuo Akira,Mark A Magnuson,Yoshimitsu Yamasaki,Yoshitaka Kajimoto,Masatsugu Hori, Biochemical and biophysical research communications, Vol. 319, No. 4, p. 1159-70, 2004/07/09
  • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, Mitsutoshi Yoneyama,Mika Kikuchi,Takashi Natsukawa,Noriaki Shinobu,Tadaatsu Imaizumi,Makoto Miyagishi,Kazunari Taira,Shizuo Akira,Takashi Fujita, Nature Immunology, Vol. 5, No. 7, p. 730-737, 2004/07
  • TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function, Anne Krug,Anthony R. French,Winfried Barchet,Jens A.A. Fischer,Andrzej Dzionek,Jeanette T. Pingel,Michael M. Orihuela,Shizuo Akira,Wayne M. Yokoyama,Marco Colonna, Immunity, Vol. 21, No. 1, p. 107-119, 2004/07
  • Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury, Masanori Kishino,Kazunori Yukawa,Katsuaki Hoshino,Akihiko Kimura,Nobuyuki Shirasawa,Haruhisa Otani,Tetsuji Tanaka,Kyoko Owada-Makabe,Yuji Tsubota,Masanobu Maeda,Masakazu Ichinose,Kiyoshi Takeda,Shizuo Akira,Masatoshi Mune, Journal of the American Society of Nephrology, Vol. 15, No. 7, p. 1826-1834, 2004/07
  • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein I kappa B zeta, M Yamamoto,S Yamazaki,S Uematsu,S Sato,H Hemmi,K Hoshino,T Kaisho,H Kuwata,O Takeuchi,K Takeshige,T Saitoh,S Yamaoka,N Yamamoto,S Yamamoto,T Muta,K Takeda,S Akira, NATURE, NATURE PUBLISHING GROUP, Vol. 430, No. 6996, p. 218-222, 2004/07
  • Toll-like receptor signalling, S Akira,K Takeda, NATURE REVIEWS IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 4, No. 7, p. 499-511, 2004/07
  • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes, Melissa W. Boulé,Courtney Broughton,Fabienne Mackay,Shizuo Akira,Ann Marshak-Rothstein,Ian R. Rifkin, Journal of Experimental Medicine, Vol. 199, No. 12, p. 1631-1640, 2004/06/21
  • Functions of toll-like receptors: Lessons from KO mice, Shizuo Akira,Kiyoshi Takeda, Comptes Rendus - Biologies, Vol. 327, No. 6, p. 581-589, 2004/06
  • Membrane-associated prostaglandin E synthase-I is required for neuropathic pain, T Mabuchi,H Kojima,T Abe,K Takagi,M Sakurai,Y Ohmiya,S Uematsu,S Akira,K Watanabe,S Ito, NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, Vol. 15, No. 9, p. 1395-1398, 2004/06
  • Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina, Yoko Ozawa,Keiko Nakao,Takuya Shimazaki,Junji Takeda,Shizuo Akira,Katsuhiko Ishihara,Toshio Hirano,Yoshihisa Oguchi,Hideyuki Okano, Molecular and Cellular Neuroscience, Vol. 26, No. 2, p. 258-270, 2004/06
  • The roles of two I kappa B kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection, H Hemmi,O Takeuchi,S Sato,M Yamamoto,T Kaisho,H Sanjo,T Kawai,K Hoshino,K Takeda,S Akira, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 199, No. 12, p. 1641-1650, 2004/06
  • Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells, Toru Hosoi,Sawako Suzuki,Jun Nomura,Atsushi Ono,Yasunobu Okuma,Shizuo Akira,Yasuyuki Nomura, Molecular Brain Research, Vol. 124, No. 2, p. 159-164, 2004/05/19
  • Dual Role of TLR2 and Myeloid Differentiation Factor 88 in a Mouse Model of Invasive Group B Streptococcal Disease, Giuseppe Mancuso,Angelina Midiri,Concetta Beninati,Camelo Biondo,Roberta Galbo,Shizuo Akira,Philipp Henneke,Douglas Golenbock,Giuseppe Teti, Journal of Immunology, American Association of Immunologists, Vol. 172, No. 10, p. 6324-6329, 2004/05/15
  • Glucocorticoids synergie with IL-1β to induced TLR2 expression via MAP Kinase phosphatase-1-dependent dual inhibition of MAPK JNK and p38 in epithelial cells, Akihiro Sakai,Jiahuai Han,Andrew C.B. Cato,Shizuo Akira,Jian-Dong Li, BMC Molecular Biology, Vol. 5, 2004/05/04
  • Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse, Keisuke Takeshita,Tsugiko Yamasaki,Shizuo Akira,Florian Gantner,Kevin B. Bacon, International Immunology, Vol. 16, No. 5, p. 685-695, 2004/05
  • Toll-like receptor 4 mediates the antitumor host response induced by a 55-Kilodalton protein isolated from Aeginetia indica L., a parasitic plant, Masato Okamoto,Oh E. Go,Tetsuya Oshikawa,Sachiko Furuichi,Tomoyuki Tano,Sharif U. Ahmed,Sachiko Akashi,Kensuke Miyake,Osamu Takeuchi,Shizuo Akira,Kunisuke Himeno,Mitsunobu Sato,Shinya Ohkubo, Clinical and Diagnostic Laboratory Immunology, Vol. 11, No. 3, p. 483-495, 2004/05
  • A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells, Stephanie Dillon,Anshu Agrawal,Thomas Van Dyke,Gary Landreth,Laurie McCauley,Amy Koh,Charles Maliszewski,Shizuo Akira,Bali Pulendran, Journal of Immunology, American Association of Immunologists, Vol. 172, No. 8, p. 4733-4743, 2004/04/15
  • Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway., Sathit Pichyangkul,Kosol Yongvanitchit,Utaiwan Kum-arb,Hiroaki Hemmi,Shizuo Akira,Arthur M Krieg,D Gray Heppner,V Ann Stewart,Hitoshi Hasegawa,Sornchai Looareesuwan,G Dennis Shanks,R Scott Miller, Journal of immunology (Baltimore, Md. : 1950), Vol. 172, No. 8, p. 4926-33, 2004/04/15
  • Interferon-γ production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18, Kazuyoshi Kawakami,Yuki Kinjo,Kaori Uezu,Kazuya Miyagi,Takeshi Kinjo,Satomi Yara,Yoshinobu Koguchi,Akiko Miyazato,Kazutoshi Shibuya,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito, Microbes and Infection, Vol. 6, No. 4, p. 339-349, 2004/04
  • Toll-Like Receptor 2 Is Required for Optimal Control of Listeria monocytogenes Infection, David Torres,Mathieu Barrier,Franck Bihl,Valerie J. F. Quesniaux,Isabelle Maillet,Shizuo Akira,Bernhard Ryffel,François Erard, Infection and Immunity, Vol. 72, No. 4, p. 2131-2139, 2004/04
  • Toll-Like Receptors Are Temporally Involved in Host Defense, David S. Weiss,Bärbel Raupach,Kiyoshi Takeda,Shizuo Akira,Arturo Zychlinsky, Journal of Immunology, American Association of Immunologists, Vol. 172, No. 7, p. 4463-4469, 2004/04/01
  • Production of IL-12 by Macrophages Infected with Toxoplasma gondii Depends on the Parasite Genotype, Paul M. Robben,Dana G. Mordue,Steven M. Truscott,Kiyoshi Takeda,Shizuo Akira,L. David Sibley, Journal of Immunology, American Association of Immunologists, Vol. 172, No. 6, p. 3686-3694, 2004/03/15
  • Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4, Amélie Honstettre,Eric Ghigo,Alix Moynault,Christian Capo,Rudolf Toman,Shizuo Akira,Osamu Takeuchi,Hubert Lepidi,Didier Raoult,Jean Louis Mege, Journal of Immunology, Vol. 172, No. 6, p. 3695-3703, 2004/03/15
  • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA., Sandra S Diebold,Tsuneyasu Kaisho,Hiroaki Hemmi,Shizuo Akira,Caetano Reis e Sousa, Science (New York, N.Y.), Vol. 303, No. 5663, p. 1529-31, 2004/03/05
  • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8., Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten Kirschning,Shizuo Akira,Grayson Lipford,Hermann Wagner,Stefan Bauer, Science (New York, N.Y.), Vol. 303, No. 5663, p. 1526-9, 2004/03/05
  • Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense, Sylvia Knapp,Catharina W. Wieland,Cornelis Van't Veer,Osamu Takeuchi,Shizuo Akira,Sandrine Florquin,Tom Van Der Poll, Journal of Immunology, Vol. 172, No. 5, p. 3132-3138, 2004/03/01
  • Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages, Akiko Shiratsuchi,Ikuko Watanabe,Osamu Takeuchi,Shizuo Akira,Yoshinobu Nakanishi, Journal of Immunology, Vol. 172, No. 4, p. 2039-2047, 2004/02/15
  • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo, Hiroshi Inoue,Wataru Ogawa,Michitaka Ozaki,Sanae Haga,Michihiro Matsumoto,Kensuke Furukawa,Naoko Hashimoto,Yoshiaki Kido,Toshiyuki Mori,Hiroshi Sakaue,Kiyoshi Teshigawara,Shiyu Jin,Haruhisa Iguchi,Ryuji Hiramatsu,Derek LeRoith,Kiyoshi Takeda,Shizuo Akira,Masato Kasuga, Nature Medicine, Vol. 10, No. 2, p. 168-174, 2004/02
  • Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection with Trypanosoma cruzi in Mice Lacking Functional Myeloid Differentiation Factor 88, Marco A. Campos,Meire Closel,Eneida P. Valente,Jarbas E. Cardoso,Shizuo Akira,Jacqueline I. Alvarez-Leite,Catherine Ropert,Ricardo T. Gazzinelli, Journal of Immunology, American Association of Immunologists, Vol. 172, No. 3, p. 1711-1718, 2004/02/01
  • Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration, Mathias Heikenwalder,Magdalini Polymenidou,Tobias Junt,Christina Sigurdson,Hermann Wagner,Shizuo Akira,Rolf Zinkernagel,Adriano Aguzzi, Nature Medicine, Vol. 10, No. 2, p. 187-192, 2004/02
  • Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium, M. Salomé Gomes,Manuela Flórido,João V. Cordeiro,C. Miguel Teixeira,Osamu Takeuchi,Shizuo Akira,Rui Appelberg, Immunology, Vol. 111, No. 2, p. 179-185, 2004/02
  • Adjuvant-Mediated Tumor Regression and Tumor-Specific Cytotoxic Response Are Impaired in MyD88-Deficient Mice, Takashi Akazawa,Hisayo Masuda,Yoshiko Saeki,Misako Matsumoto,Kiyoshi Takeda,Kunio Tsujimura,Kiyotaka Kuzushima,Toshitada Takahashi,Ichiro Azuma,Shizuo Akira,Kumao Toyoshima,Tsukasa Seya, Cancer Research, Vol. 64, No. 2, p. 757-764, 2004/01/15
  • Stat-3 is required for pulmonary homeostasis during hyperoxia, Isamu Hokuto,Machiko Ikegami,Mitsuhiro Yoshida,Kiyoshi Takeda,Shizuo Akira,Anne-Karina T. Perl,William M. Hull,Susan E. Wert,Jeffrey A. Whitsett, Journal of Clinical Investigation, The American Society for Clinical Investigation, Vol. 113, No. 1, p. 28-37, 2004
  • Toll-Like Receptor 9 Signaling Mediates the Anti-inflammatory Effects of Probiotics in Murine Experimental Colitis, Daniel Rachmilewitz,Kyoko Katakura,Fanny Karmeli,Tomoko Hayashi,Constantin Reinus,Bernard Rudensky,Shizuo Akira,Kiyoshi Takeda,Jongdae Lee,Kenji Takabayashi,Eyal Raz, Gastroenterology, W.B. Saunders, Vol. 126, No. 2, p. 520-528, 2004
  • Elucidation of the c-Jun N-Terminal Kinase Pathway Mediated by Epstein-Barr Virus-Encoded Latent Membrane Protein 1, Jun Wan,Luguo Sun,Jennifer Woo Mendoza,Yiu Loon Chui,Dolly P. Huang,Zhijian J. Chen,Nobutaka Suzuki,Shinobu Suzuki,Wen-Chen Yeh,Shizuo Akira,Kunihiro Matsumoto,Zheng-Gang Liu,Zhenguo Wu, Molecular and Cellular Biology, Vol. 24, No. 1, p. 192-199, 2004/01
  • Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells, Ann Marshak-Rothstein,Liliana Busconi,Christina M. Lau,Abigail S. Tabor,Elizabeth A. Leadbetter,Shizuo Akira,Arthur M. Krieg,Grayson B. Lipford,Gregory A. Viglianti,Ian R. Rifkin, Journal of Endotoxin Research, Vol. 10, No. 4, p. 247-251, 2004
  • The role of IFN-γ and toll-like receptors in nephropathy induced by Toxoplasma gondii infection, Masamichi Kudo,Fumie Aosai,Hye-Seong Mun,Kazumi Norose,Shizuo Akira,Yoichiko Iwakura,Akihiko Yano, Microbiology and Immunology, Center for Academic Publications Japan, Vol. 48, No. 8, p. 617-628, 2004
  • Expression of Toll-like receptors 2 and 4 is downregulated after operation, Hirofumi Ikushima,Toshirou Nishida,Kiyoshi Takeda,Toshinori Ito,Takushi Yasuda,Masahiko Yano,Shizuo Akira,Hikaru Matsuda, Surgery, Mosby Inc., Vol. 135, No. 4, p. 376-385, 2004
  • Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors, Hongmei Zhao,Hiraoki Hemmi,Shizuo Akira,Seng H. Cheng,Ronald K. Scheule,Nelson S. Yew, Molecular Therapy, Academic Press Inc., Vol. 9, No. 2, p. 241-248, 2004
  • Interferon response by Toll-like receptor signaling, Osamu Takeuchi,Hiroaki Hemmi,Shizuo Akira, Journal of Endotoxin Research, Vol. 10, No. 4, p. 252-256, 2004
  • TIR domain-containing adaptors define the specificity of TLR signaling, Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira, Molecular Immunology, Elsevier Ltd, Vol. 40, No. 12, p. 861-868, 2004
  • Gamma Interferon (IFN-γ) and IFN-γ-Inducing Cytokines Interleukin-12 (IL-12) and IL-18 Do Not Augment Infection- Stimulated Bone Resorption In Vivo, Hajime Sasaki,Khaled Balto,Nobuyuki Kawashima,Jean Eastcott,Katsuaki Hoshino,Shizuo Akira,Philip Stashenko, Clinical and Diagnostic Laboratory Immunology, Vol. 11, No. 1, p. 106-110, 2004/01
  • Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy., Yukawa K,Hoshino K,Kishino M,Mune M,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Tanaka T,Ichinose M,Maeda M,Takeda K,Akira S, International journal of molecular medicine, Vol. 13, No. 4, p. 515-520, 2004
  • Epstein-Barr virus latent membrane protein 1 activation of NF-κB through IRAK1 and TRAF6, Micah Luftig,Efthimios Prinarakis,Teruhito Yasui,Theodore Tsichritzis,Ellen Cahir-McFarland,Jun-Ichiro Inoue,Hiroyasu Nakano,Tak Wah Mak,Wen-Chen Yeh,Xiaoxia Li,Shizuo Akira,Nobutaka Suzuki,Shinobu Suzuki,George Mosialos,Elliott Kieff, Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 26, p. 15595-15600, 2003/12/23
  • Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction, Tetsuro Shishido,Naoki Nozaki,Seiji Yamaguchi,Yoko Shibata,Joji Nitobe,Takuya Miyamoto,Hiroki Takahashi,Takanori Arimoto,Kunihiko Maeda,Mitsunori Yamakawa,Osamu Takeuchi,Shizuo Akira,Yasuchika Takeishi,Isao Kubota, Circulation, Vol. 108, No. 23, p. 2905-2910, 2003/12/09
  • Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid Differentiation Factor 88, Leo A. B. Joosten,Marije I. Koenders,Ruben L. Smeets,Marleen Heuvelmans-Jacobs,Monique M. A. Helsen,Kiyoshi Takeda,Shizuo Akira,Erik Lubberts,Fons A. J. Van De Loo,Wim B. Van Den Berg, Journal of Immunology, American Association of Immunologists, Vol. 171, No. 11, p. 6145-6153, 2003/12/01
  • Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils, Akihiro Matsukawa,Kiyoshi Takeda,Shinji Kudo,Takako Maeda,Motoko Kagayama,Shizuo Akira, Journal of Immunology, American Association of Immunologists, Vol. 171, No. 11, p. 6198-6205, 2003/12/01
  • IL-1R-Associated Kinase 4 Is Required for Lipopolysaccharide-Induced Activation of APC, Nobutaka Suzuki,Shinobu Suzuki,Urs Eriksson,Hiromitsu Hara,Christine Mirtosis,Nien-Jung Chen,Teiji Wada,Denis Bouchard,Irene Hwang,Kiyoshi Takeda,Takashi Fujita,Sandy Der,Josef M. Penninger,Shizuo Akira,Takashi Saito,Wen-Chen Yeh, Journal of Immunology, American Association of Immunologists, Vol. 171, No. 11, p. 6065-6071, 2003/12/01
  • Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice, R. Iiyama,T. Kanai,K. Uraushihara,T. Ishikura,S. Makita,T. Totsuka,M. Yamazaki,T. Nakamura,T. Miyata,H. Yoshida,O. Takeuchi,K. Hoshino,K. Takeda,H. Ishikawa,S. Akirat,M. Watanabe, Scandinavian Journal of Immunology, Vol. 58, No. 6, p. 620-627, 2003/12
  • IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages, Hirotaka Kuwata,Yasuyuki Watanabe,Hiroyuki Miyoshi,Masahiro Yamamoto,Tsuneyasu Kaisho,Kiyoshi Takeda,Shizuo Akira, Blood, Vol. 102, No. 12, p. 4123-4129, 2003/12/01
  • Antigenic Epitopes Fused to Cationic Peptide Bound to Oligonucleotides Facilitate Toll-Like Receptor 9-Dependent, but CD4+ T Cell Help-Independent, Priming of CD8+ T Cells, Reinhold Schirmbeck,Petra Riedl,Rinaldo Zurbriggen,Shizuo Akira,Jörg Reimann, Journal of Immunology, American Association of Immunologists, Vol. 171, No. 10, p. 5198-5207, 2003/11/15
  • The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily., Florian Heil,Parviz Ahmad-Nejad,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Tanja Gellert,Harald Dietrich,Grayson Lipford,Kiyoshi Takeda,Shizuo Akira,Hermann Wagner,Stefan Bauer, European journal of immunology, Vol. 33, No. 11, p. 2987-97, 2003/11
  • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway, Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Satoshi Uematsu,Katsuaki Hoshino,Tsuneyasu Kaisho,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira, Nature Immunology, Vol. 4, No. 11, p. 1144-1150, 2003/11
  • X-ray crystal structure of IRF-3 and its functional implications, Kiyohiro Takahasi,Nobuo N. Suzuki,Masataka Horiuchi,Mitsuaki Mori,Wakako Suhara,Yasutaka Okabe,Yukiko Fukuhara,Hiroaki Terasawa,Shizuo Akira,Takashi Fujita,Fuyuhiko Inagaki, Nature Structural Biology, Vol. 10, No. 11, p. 922-927, 2003/11
  • Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the toll-like receptor signaling, Shintaro Sato,Masanaka Sugiyama,Masahiro Yamamoto,Yasuyuki Watanabe,Taro Kawai,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, Vol. 171, No. 8, p. 4304-4310, 2003/10/15
  • MyD88 primes macrophages for full-scale activation by interferon-γ yet mediates few responses to Mycobacterium tuberculosis, Shuangping Shi,Carl Nathan,Dirk Schnappinger,Jörg Drenkow,Michele Fuortes,Ellen Block,Aihao Ding,Thomas R. Gingeras,Gary Schoolnik,Shizuo Akira,Kiyoshi Takeda,Sabine Ehrt, Journal of Experimental Medicine, Vol. 198, No. 7, p. 987-997, 2003/10/06
  • Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms, Sanae Haga,Keita Terui,Hui Qi Zhang,Shin Enosawa,Wataru Ogawa,Hiroshi Inoue,Torayuki Okuyama,Kiyoshi Takeda,Shizuo Akira,Tetsuya Ogino,Kaikobad Irani,Michitaka Ozaki, Journal of Clinical Investigation, Vol. 112, No. 7, p. 989-998, 2003/10
  • Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis, Sebastiaan Weijer,Miguel E. Sewnath,Alex F. De Vos,Sandrine Florctuin,Koen Van der Sluis,Dirk J. Gouma,Kiyoshi Takeda,Shizuo Akira,Tom Van der Poll, Infection and Immunity, Vol. 71, No. 10, p. 5488-5497, 2003/10/01
  • Immunogenicity of peptide-25 of Ag85B in Th 1 development: Role of IFN-γ, Ai Kariyone,Toshiki Tamura,Hideyuki Kano,Yoichiro Iwakura,Kiyoshi Takeda,S. Akira,Kiyoshi Takatsu, International Immunology, Vol. 15, No. 10, p. 1183-1194, 2003/10/01
  • Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection, Kenya Honda,Shinya Sakaguchi,Chigusa Nakajima,Ai Watanabe,Hideyuki Yanai,Misako Matsumoto,Toshiaki Ohteki,Tsuneyasu Kaisho,Akinori Takaoka,Shizuo Akira,Tsukasa Seya,Tadatsugu Taniguchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 19, p. 10872-10877, 2003/09/16
  • Integral role of Noxa in p53-mediated apoptotic response, Tsukasa Shibue,Kiyoshi Takeda,Eri Oda,Hiroshi Tanaka,Hideki Murasawa,Akinori Takaoka,Yasuyuki Morishita,Shizuo Akira,Tadatsugu Taniguchi,Nobuyuki Tanaka, Genes and Development, Vol. 17, No. 18, p. 2233-2238, 2003/09/15
  • A critical role for Stat3 signaling in immune tolerance, Fengdong Cheng,Hong-Wei Wang,Alex Cuenca,Mei Huang,Tomar Ghansah,Jason Brayer,William G. Kerr,Kiyoshi Takeda,Shizuo Akira,Stephen P. Schoenberger,Hua Yu,Richard Jove,Eduardo M. Sotomayor, Immunity, Cell Press, Vol. 19, No. 3, p. 425-436, 2003/09/01
  • Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens, Kieren A. Marr,S. Arunmozhi Balajee,Thomas R. Hawn,Adrian Ozinsky,Uyenvy Pham,Shizuo Akira,Alan Aderem,W. Conrad Liles, Infection and Immunity, Vol. 71, No. 9, p. 5280-5286, 2003/09/01
  • ZIP kinase triggers apoptosis from nuclear PML oncogenic domains, Taro Kawai,Shizuo Akira,John C. Reed, Molecular and Cellular Biology, Vol. 23, No. 17, p. 6174-6186, 2003/09
  • Cutting edge: The B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer's patches and affects B cell trafficking across high endothelial venules, Yukihiko Ebisuno,Toshiyuki Tanaka,Naotoshi Kanemitsu,Hidenobu Kanda,Kazuhito Yamaguchi,Tsuneyasu Kaisho,Shizuo Akira,Masayuki Miyasaka, Journal of Immunology, American Association of Immunologists, Vol. 171, No. 4, p. 1642-1646, 2003/08/15
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes, Norihito Yazawa,Manabu Fujimoto,Shinichi Sato,Kensuke Miyake,Noriko Asano,Yoshinori Nagai,Osamu Takeuchi,Kiyoshi Takeda,Hitoshi Okochi,Shizuo Akira,Thomas F. Tedder,Kunihiko Tamaki, Blood, 4, Vol. 102, No. 4, p. 1374-1380, 2003/08/15
  • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells, Jennifer Lund,Ayuko Sato,Shizuo Akira,Ruslan Medzhitov,Akiko Iwasaki, Journal of Experimental Medicine, Vol. 198, No. 3, p. 513-520, 2003/08/04
  • Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells, J. H. Zhang,H. He,A. M. Borzychowski,K. Takeda,S. Akira,B. A. Croy, Biology of Reproduction, Vol. 69, No. 2, p. 404-411, 2003/08/01
  • Simultaneous blocking of human toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan, Junji Uehori,Misako Matsumoto,Shoutaro Tsuji,Takashi Akazawa,Osamu Takeuchi,Shizuo Akira,Tsutomu Kawata,Ichiro Azuma,Kumao Toyoshima,Tsukasa Seya, Infection and Immunity, Vol. 71, No. 8, p. 4238-4249, 2003/08/01
  • Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice, H. Takagi,T. Kanai,A. Okazawa,Y. Kishi,T. Sato,H. Takaishi,N. Inoue,H. Ogata,Y. Iwao,K. Hoshino,K. Takeda,S. Akira,M. Watanabe,H. Ishii,Toshifumi Hibi, Scandinavian Journal of Gastroenterology, Vol. 38, No. 8, p. 837-844, 2003/08/01
  • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway, Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hideki Sanjo,Osamu Takeuchi,Masanaka Sugiyama,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira, Science, Vol. 301, No. 5633, p. 640-643, 2003/08/01
  • CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells, Ningshu Liu,Noriko Ohnishi,Lin Ni.,Shizuo Akira,Kevin B. Bacon, Nature Immunology, Vol. 4, No. 7, p. 687-693, 2003/07/01
  • Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice, Rima Elhage,Jacek Jawien,Mats Rudling,Hans-Gustaf Ljunggren,Kiyoshi Takeda,Shizuo Akira,Francis Bayard,Göran K. Hansson, Cardiovascular Research, Vol. 59, No. 1, p. 234-240, 2003/07/01
  • Candida albicans phospholipomannan is sensed through toll-like receptors, Thierry Jouault,Stella Ibata-Ombetta,Osamu Takeuchi,Pierre André Trinel,Paola Sacchetti,Philippe Lefebvre,Shizuo Akira,Daniel Poulain, Journal of Infectious Diseases, Vol. 188, No. 1, p. 165-172, 2003/07/01
  • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages, Hideo Yasukawa,Masanobu Ohishi,Hiroyuki Mori,Masaaki Murakami,Takatoshi Chinen,Daisuke Aki,Toshikatsu Hanada,Kiyoshi Takeda,Shizuo Akira,Masahiko Hoshijima,Toshio Hirano,Kenneth R. Chien,Akihiko Yoshimura, Nature Immunology, Vol. 4, No. 6, p. 551-556, 2003/06/01
  • Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines, Osamu Muraoka,Bo Xu,Tatsuru Tsurumaki,Shizuo Akira,Tsuyoshi Yamaguchi,Hiroshi Higuchi, Neurochemistry International, Vol. 42, No. 7, p. 591-601, 2003/06
  • Myeloid differentiation factor 88-dependent and -independent pathways in Toll-like receptor signaling, S Akira,K Hoshino, JOURNAL OF INFECTIOUS DISEASES, UNIV CHICAGO PRESS, Vol. 187, p. S356-S363, 2003/06
  • Role of adapters in Toll-like receptor signalling, S. Akira,M. Yamamoto,K. Takeda, Biochemical Society Transactions, Vol. 31, No. 3, p. 637-642, 2003/06
  • Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2, Benjamin N. Gantner,Randi M. Simmons,Scott J. Canavera,Shizuo Akira,David M. Underhill, Journal of Experimental Medicine, Vol. 197, No. 9, p. 1107-1117, 2003/05/05
  • Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection, Daniel R. Goldstein,Bethany M. Tesar,Shizuo Akira,Fadi G. Lakkis, Journal of Clinical Investigation, Vol. 111, No. 10, p. 1571-1578, 2003/05
  • Activation and regulation of Toll-like receptors 2 and 1 in human leprosy, Krutzik, SR,MT Ochoa,PA Sieling,S Uematsu,YW Ng,A Legaspi,PT Liu,ST Cole,PJ Godowski,YM Maeda,EN Sarno,MV Norgard,PJ Brennan,S Akira,TH Rea,RL Modlin, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 9, No. 5, p. 525-532, 2003/05
  • A subset of toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells, Sandip K. Datta,Vanessa Redecke,Kiley R. Prilliman,Kenji Takabayashi,Maripat Corr,Thomas Tallant,Joseph DiDonato,Roman Dziarski,Shizuo Akira,Stephen P. Schoenberger,Eyal Raz, Journal of Immunology, American Association of Immunologists, Vol. 170, No. 8, p. 4102-4110, 2003/04/15
  • Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa, Marc J. Schultz,Sylvia Knapp,Sandrine Florquin,Jennie Pater,Kiyoshi Takeda,Shizuo Akira,Tom Van der Poll, Infection and Immunity, Vol. 71, No. 4, p. 1630-1634, 2003/04/01
  • Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines., Alexander D Edwards,Sandra S Diebold,Emma M C Slack,Hideyuki Tomizawa,Hiroaki Hemmi,Tsuneyasu Kaisho,Shizuo Akira,Caetano Reis e Sousa, European journal of immunology, Vol. 33, No. 4, p. 827-33, 2003/04
  • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets., Hiroaki Hemmi,Tsuneyasu Kaisho,Kiyoshi Takeda,Shizuo Akira, Journal of immunology (Baltimore, Md. : 1950), Vol. 170, No. 6, p. 3059-64, 2003/03/15
  • Involvement of Toll-like receptor 4 signaling in interferon-γ production and antitumor effect by streptococcal agent OK-432, Masato Okamoto,Tetsuya Oshikawa,Tomuyuki Tano,Go Ohe,Sachiko Furuichi,Hidetomo Nishikawa,Sharif Uddin Ahmed,Sachiko Akashi,Kensuke Miyake,Osamu Takeuchi,Shizuo Akira,Yoichiro Moriya,Shuzo Marsubara,Yoshiki Ryoma,Motoo Saito,Mitsunobu Sato, Journal of the National Cancer Institute, Vol. 95, No. 4, p. 316-326, 2003/02/19
  • TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling, Hideki Sanjo,Kiyoshi Takeda,Tohru Tsujimura,Jun Ninomiya-Tsuji,Kunihiro Matsumoto,Shizuo Akira, Molecular and Cellular Biology, Vol. 23, No. 4, p. 1231-1238, 2003/02
  • Prion pathogenesis in the absence of Toll-like receptor signalling, Marco Prinz,Mathias Heikenwalder,Petra Schwarz,Kiyoshi Takeda,Shizuo Akira,Adriano Aguzzi, EMBO Reports, Vol. 4, No. 2, p. 195-199, 2003/02/01
  • Suppression of allergic reaction by λ-carrageenan: Toll-like receptor 4/MyD88-dependent and -independent modulation of immunity, Ryohei F. Tsuji,K. Hoshino,Y. Noro,N. M. Tsuji,T. Kurokawa,T. Masuda,S. Akira,B. Nowak, Clinical and Experimental Allergy, Vol. 33, No. 2, p. 249-258, 2003/02
  • Recognition of pathogen-associated molecular patterns by TLR family., Shizuo Akira,Hiroaki Hemmi, Immunology letters, Vol. 85, No. 2, p. 85-95, 2003/01/22
  • Sequential MyD88-Independent and -Dependent Activation of Innate Immune Responses to Intracellular Bacterial Infection, Natalya V. Serbina,William Kuziel,Richard Flavell,Shizuo Akira,Barrett Rollins,Eric G. Pamer, Immunity, Cell Press, Vol. 19, No. 6, p. 891-901, 2003
  • Mycobacterial Infection in MyD88-Deficient Mice, Isamu Sugawara,Hiroyuki Yamada,Satoru Mizuno,Kiyoshi Takeda,Shizuo Akira, Microbiology and Immunology, Center for Academic Publications Japan, Vol. 47, No. 11, p. 841-847, 2003
  • Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis, Petra J.G. Zwijnenburg,Tom Van Der Poll,Sandrine Florquin,Shizuo Akira,Kiyoshi Takeda,John J. Roord,A. Marceline Van Furth, Journal of Neuroimmunology, Elsevier, Vol. 138, No. 1-2, p. 31-37, 2003
  • Mycobacterial infection in TLR2 and TLR6 knockout mice, Isamu Sugawara,Hiroyuki Yamada,Chuanyou Li,Satoru Mizuno,Osamu Takeuchi,Shizuo Akira, Microbiology and Immunology, Vol. 47, No. 5, p. 327-336, 2003
  • Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2, R Girard,T Pedron,S Uematsu,Balloy, V,M Chignard,S Akira,R Chaby, JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LTD, Vol. 116, No. 2, p. 293-302, 2003/01
  • Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, toll-like receptor 4, MD-2 and MyD88 expression, Riyoko Tamai,Shunji Sugawara,Osamu Takeuchi,Shizuo Akira,Haruhiko Takada, Journal of Endotoxin Research, Vol. 9, No. 3, p. 145-153, 2003
  • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice, Masaya Kobayashi,Mi-Na Kweon,Hirotaka Kuwata,Robert D. Schreiber,Hiroshi Kiyono,Kiyoshi Takeda,Shizuo Akira, Journal of Clinical Investigation, The American Society for Clinical Investigation, Vol. 111, No. 9, p. 1297-1308, 2003
  • Toll-like receptors and their signaling mechanisms, Shizuo Akira,Shintaro Sato, Scandinavian Journal of Infectious Diseases, Vol. 35, No. 9, p. 555-562, 2003
  • Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling, Masahiro Yamamoto,Shintaro Sato,Kiyotoshi Mori,Katsuaki Hoshino,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, Vol. 169, No. 12, p. 6668-6672, 2002/12/15
  • Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of Toll-like receptor 2, Akira Imasato,Christéle Desbois-Mouthon,Jiahuai Han,Hirofumi Kai,Andrew C. B. Cato,Shizuo Akira,Jian-Dong Li, Journal of Biological Chemistry, Vol. 277, No. 49, p. 47444-47450, 2002/12/06
  • Differential recognition of structural details of bacterial lipopeptides by toll-like receptors, Michael Morr,Osamu Takeuchi,Shizuo Akira,Markus M. Simon,Peter F. Mühlradt, European Journal of Immunology, Vol. 32, No. 12, p. 3337-3347, 2002/12/01
  • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Hideki Sanjo,Satoshi Uematsu,Tsuneyasu Kaisho,Katsuaki Hoshino,Osamu Takeuchi,Masaya Kobayashi,Takashi Fujita,Kiyoshi Takeda,Shizuo Akira, Nature, Vol. 420, No. 6913, p. 324-329, 2002/11/21
  • Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88- dependent signaling pathway, Tomohiko Ogawa,Yasuyuki Asai,Masahito Hashimoto,Osamu Takeuchi,Tomoko Kurita,Yasunobu Yoshikai,Kensuke Miyake,Shizuo Akira, International Immunology, Vol. 14, No. 11, p. 1325-1332, 2002/11/01
  • SOCS-1 participates in negative regulation of LPS responses, Reiko Nakagawa,Tetsuji Naka,Hiroko Tsutsui,Minoru Fujimoto,Akihiro Kimura,Tatsuo Abe,Ekihiro Seki,Shintaro Sato,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira,Koichi Yamanishi,Ichirou Kawase,Kenji Nakanishi,Tadamitsu Kishimoto, Immunity, Vol. 17, No. 5, p. 677-687, 2002/11/01
  • Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice, Hideyuki Shimizu,Tetsuya Matsuguchi,Yoshihide Fukuda,Isao Nakano,Tetsuo Hayakawa,Osamu Takeuchi,Shizuo Akira,Masayuki Umemura,Takashi Suda,Yasunobu Yoshikai, Gastroenterology, Vol. 123, No. 4, p. 1265-1277, 2002/10
  • Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways, Philipp Henneke,Osamu Takeuchi,Richard Malley,Egil Lien,Robin R. Ingalls,Mason W. Freeman,Tanya Mayadas,Victor Nizet,Shizuo Akira,Dennis L. Kasper,Douglas T. Golenbock, Journal of Immunology, Vol. 169, No. 7, p. 3970-3977, 2002/10/01
  • Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen, Fumie Aosai,Mei Chen,Hyun Kyu Kang,Hye Seong Mun,Kazumi Norose,Lian Xun Piao,Masashi Kobayashi,Osamu Takeuchi,Shizuo Akira,Akihiko Yano, Cell Stress and Chaperones, Vol. 7, No. 4, p. 357-364, 2002/10
  • Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice, Ekihiro Seki,Hiroko Tsutsui,Noriko M. Tsuji,Nobuki Hayashi,Keishi Adachi,Hiroki Nakano,Shizue Futatsugi-Yumikura,Osamu Takeuchi,Katsuaki Hoshino,Shizuo Akira,Jiro Fujimoto,Kenji Nakanishi, Journal of Immunology, Vol. 169, No. 7, p. 3863-3868, 2002/10/01
  • Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers, Trude H. Flo,Liv Ryan,Eicke Latz,Osamu Takeuchi,Brian G. Monks,Egil Lien,Oyvind Halaas,Shizuo Akira,Gudmund Skjåk-Bræk,Douglas T. Golenbock,Terje Espevik, Journal of Biological Chemistry, Vol. 277, No. 38, p. 35489-35495, 2002/09/20
  • Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb, Ziad Mallat,Jean-Sébastien Silvestre,Sophie Le Ricousse-Roussanne,Laurence Lecomte-Raclet,Anne Corbaz,Michel Clergue,Micheline Duriez,Véronique Barateau,Shizuo Akira,Alain Tedgui,Gérard Tobelem,Yolande Chvatchko,Bernard I. Lévy, Circulation Research, Vol. 91, No. 5, p. 441-448, 2002/09/06
  • IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions, Hiroshi Konishi,Hiroko Tsutsui,Takaaki Murakami,Shizue Yumikura-Futatsugi,Kei-ichi Yamanaka,Minoru Tanaka,Yohichiro Iwakura,Noboru Suzuki,Kiyoshi Takeda,Shizuo Akira,Kenji Nakanishi,Hitoshi Mizutani, Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 17, p. 11340-11345, 2002/08/20
  • Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells, Naotake Tsuboi,Yasunobu Yoshikai,Seiichi Matsuo,Takeshi Kikuchi,Ken Ichiro Iwami,Yoshiyuki Nagai,Osamu Takeuchi,Shizuo Akira,Tetsuya Matsuguchi, Journal of Immunology, Vol. 169, No. 4, p. 2026-2033, 2002/08/15
  • Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses, J Kim,MT Ochoa,Krutzik, SR,O Takeuchi,S Uematsu,AJ Legaspi,HD Brightbill,D Holland,WJ Cunliffe,S Akira,PA Sieling,PJ Godowski,RL Modlin, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 169, No. 3, p. 1535-1541, 2002/08
  • Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism, Kotaro Suzuki,Hiroshi Nakajima,Shin-Ichiro Kagami,Akira Suto,Kei Ikeda,Koichi Hirose,Takaki Hiwasa,Kiyoshi Takeda,Yasushi Saito,Shizuo Akira,Itsuo Iwamoto, Journal of Experimental Medicine, Vol. 196, No. 1, p. 27-38, 2002/07/01
  • Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: A comparative study with IL-12p40, Yuki Kinjo,Kazuyoshi Kawakami,Kaori Uezu,Satomi Yara,Kazuya Miyagi,Yoshinobu Koguchi,Tomoaki Hoshino,Masaki Okamoto,Yusuke Kawase,Koichi Yokota,Kohichiro Yoshino,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito, Journal of Immunology, American Association of Immunologists, Vol. 169, No. 1, p. 323-329, 2002/07/01
  • Leishmania major activates IL-1α expression in macrophages through a MyD88-dependent pathway, Thomas R. Hawn,Adrian Ozinsky,David M. Underhill,Frederick S. Buckner,Shizuo Akira,Alan Aderem, Microbes and Infection, Vol. 4, No. 8, p. 763-771, 2002/07
  • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins, Osamu Takeuchi,Shintaro Sato,Takao Horiuchi,Katsuaki Hoshino,Kiyoshi Takeda,Zhongyun Dong,Robert L. Modlin,Shizuo Akira, Journal of Immunology, Vol. 169, No. 1, p. 10-14, 2002/07/01
  • Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets., Tomoki Ito,Ryuichi Amakawa,Tsuneyasu Kaisho,Hiroaki Hemmi,Kenichirou Tajima,Kazutaka Uehira,Yoshio Ozaki,Hideyuki Tomizawa,Shizuo Akira,Shirou Fukuhara, The Journal of experimental medicine, Vol. 195, No. 11, p. 1507-12, 2002/06/03
  • Lipopolysaccharide-dependent prostaglandin E2 production is regulated by the glutathione-dependent prostaglandin E2 synthase gene induced by the toll-like receptor 4/MyD88/NF-IL6 pathway, Satoshi Uematsu,Makoto Matsumoto,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, American Association of Immunologists, Vol. 168, No. 11, p. 5811-5816, 2002/06/01
  • Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase, Tsuyoshi Shuto,Akira Imasato,Hirofumi Jono,Akihiro Sakai,Haidong Xu,Takahiro Watanabe,Davida D. Rixter,Hirofumi Kai,Ali Andalibi,Fred Linthicum,Yue-Ling Guan,Jiahuai Han,Andrew C. B. Cato,David J. Lim,Shizuo Akira,Jian-Dong Li, Journal of Biological Chemistry, Vol. 277, No. 19, p. 17263-17270, 2002/05/10
  • Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from trypanosoma cruzi Trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-γ-primed-macrophages, Patrícia S. Coelho,André Klein,André Talvani,Sibele F. Coutinho,Osamu Takeuchi,Shizuo Akira,João S. Silva,Hélia Canizzaro,Ricardo T. Gazzinelli,Mauro M. Teixeira, Journal of Leukocyte Biology, Vol. 71, No. 5, p. 837-844, 2002/05/01
  • Essential immunoregulatory role for BCAP in B cell development and function, Tetsuo Yamazaki,Kiyoshi Takeda,Kumiko Gotoh,Hiroshi Takeshima,Shizuo Akira,Tomohiro Kurosaki, Journal of Experimental Medicine, Vol. 195, No. 5, p. 535-545, 2002/03/04
  • Interleukin 18 (Il-18) in synergy with Il-2 induces lethal lung injury in mice: A potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia, Masaki Okamoto,Seiya Kato,Kotaro Oizumi,Masaharu Kinoshita,Yoshimasa Inoue,Katsuaki Hoshino,Shizuo Akira,Andrew N.J. Mckenzie,Howard A. Young,Tomoaki Hoshino, Blood, Vol. 99, No. 4, p. 1289-1298, 2002/02/15
  • Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult, Ulrich Schweizer,Jennifer Gunnersen,Christoph Karch,Stefan Wiese,Bettina Holtmann,Kiyoshi Takeda,Shizuo Akira,Michael Sendtner, Journal of Cell Biology, Vol. 156, No. 2, p. 287-297, 2002/01/21
  • Cytokine-induced injury of the lacrimal and salivary glands, Akiko Kimura-Shimmyo,Shin-Ichiro Kashiwamura,Haruyasu Ueda,Tomohiro Ikeda,Sanae Kanno,Shizuo Akira,Kenji Nakanishi,Osamu Mimura,Haruki Okamura, Journal of Immunotherapy, Vol. 25, No. 1, p. S42-S51, 2002
  • Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes, Seiichi Oyadomari,Akio Koizumi,Kiyoshi Takeda,Tomomi Gotoh,Shizuo Akira,Eiichi Araki,Masataka Mori, Journal of Clinical Investigation, The American Society for Clinical Investigation, Vol. 109, No. 4, p. 525-532, 2002
  • Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity, Volaluck Supajatura,Hiroko Ushio,Atsuhito Nakao,Shizuo Akira,Ko Okumura,Chisei Ra,Hideoki Ogawa, Journal of Clinical Investigation, The American Society for Clinical Investigation, Vol. 109, No. 10, p. 1351-1359, 2002
  • Tamoxifen-related porphyria cutanea tarda, Yoshinori Nagai,Sachiko Akashi,Masakazu Nagafuku,Masato Ogata,Yoichiro Iwakura,Shizuo Akira,Toshio Kitamura,Atsushi Kosugi,Masao Kimoto,Kensuke Miyake, Medical Oncology, Vol. 19, No. 2, p. 121-123, 2002
  • Human gingival CD14<sup>+</sup> fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression, Riyoko Tamai,Tetsuya Sakuta,Kenji Matsushita,Mitsuo Torii,Osamu Takeuchi,Shizuo Akira,Sachiko Akashi,Terje Espevik,Shunji Sugawara,Haruhiko Takada, Infection and Immunity, Vol. 70, No. 3, p. 1272-1278, 2002
  • Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1, Takuji Yamao,Tetsuya Noguchi,Osamu Takeuchi,Uichi Nishiyama,Haruhiko Morita,Tetsuya Hagiwara,Hironori Akahori,Takashi Kato,Kenjiro Inagaki,Hideki Okazawa,Yoshitake Hayashi,Takashi Matozaki,Kiyoshi Takeda,Shizuo Akira,Masato Kasuga, J. Biol. Chem., Vol. 277, No. 42, p. 39833-39839, 2002
  • A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways, Shintaro Sato,Osamu Takeuchi,Takashi Fujita,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira, International Immunology, Vol. 14, No. 7, p. 783-791, 2002
  • Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway, Hiroaki Hemmi,Tsuneyasu Kaisho,Osamu Takeuchi,Shintaro Sato,Hideki Sanjo,Katsuaki Hoshino,Takao Horiuchi,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira, Nature Immunology, Vol. 3, No. 2, p. 196-200, 2002
  • Differential involvement of IFN-β in toll-like receptor-stimulated dendritic cell activation, K. Hoshino,T. Kaisho,T. Iwabe,O. Takeuchi,S. Akira, International Immunology, Vol. 14, No. 10, p. 1225-1231, 2002
  • Endotoxin can induce MyD88-deficient dendritic cells to support T<inf>h</inf>2 cell differentiation, Tsuneyasu Kaisho,Katsuaki Hoshino,Tomio Iwabe,Osamu Takeuchi,Teruhito Yasui,Shizuo Akira, International Immunology, Vol. 14, No. 7, p. 695-700, 2002
  • Immunology: Bug detectors, Tsuneyasu Kaisho,Shizuo Akira, Nature, Vol. 414, No. 6865, p. 701-703, 2001/12/13
  • Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases., M Nomi,I Oishi,S Kani,H Suzuki,T Matsuda,A Yoda,M Kitamura,K Itoh,S Takeuchi,K Takeda,S Akira,M Ikeya,S Takada,Y Minami, Molecular and cellular biology, Vol. 21, No. 24, p. 8329-35, 2001/12
  • Lipopolysaccharide stimulates the MyaD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes, T. Kawai,O. Takeuchi,T. Fujita,J. I. Inoue,P. F. Mühlradt,S. Sato,K. Hoshino,S. Akira, Journal of Immunology, Vol. 167, No. 10, p. 5887-5894, 2001/11/15
  • Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway, Seiichi Oyadomari,Kiyoshi Takeda,Masaki Takiguchi,Tomomi Gotoh,Makoto Matsumoto,Ikuo Wada,Shizuo Akira,Eiichi Araki,Masataka Mori, Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 19, p. 10845-10850, 2001/09/11
  • Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition, Stefan Bauer,Carsten J. Kirschning,Hans Häcker,Vanessa Redecke,Susanne Hausmann,Shizuo Akira,Hermann Wagner,Grayson B. Lipford, Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 16, p. 9237-9242, 2001/07/31
  • Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus, Surendran Mahalingam,Gunasegaran Karupiah,Kiyoshi Takeda,Shizuo Akira,Klaus I. Matthaei,Paul S. Foster, Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 12, p. 6812-6817, 2001/06/05
  • Toll-like receptors and their signaling mechanism in innate immunity, Tsuneyasu Kaisho,Shizuo Akira, Acta Odontologica Scandinavica, Vol. 59, No. 3, p. 124-130, 2001/06
  • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5, Fumitaka Hayashi,Kelly D. Smith,Adrian Ozinsky,Thomas R. Hawn,Eugene C. Yi,David R. Goodlett,Jimmy K. Eng,Shizuo Akira,David M. Underhill,Alan Aderem, Nature, Vol. 410, No. 6832, p. 1099-1103, 2001/04/26
  • CCAAT/enhancer-binding protein β is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes, Tatsuya Kimura,Shoaib Chowdhury,Takashi Tanaka,Atsuko Shimizu,Katsuro Iwase,Seiichi Oyadomari,Tomomi Gotoh,Hiromitsu Matsuzaki,Masataka Mori,Shizuo Akira,Masaki Takiguchi, FEBS Letters, Vol. 494, No. 1-2, p. 105-111, 2001/04/06
  • Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I, Akemi Matsushima,Tsuneyasu Kaisho,Paul D. Rennert,Hiroyasu Nakano,Kyoko Kurosawa,Daisuke Uchida,Kiyoshi Takeda,Shizuo Akira,Mitsuru Matsumoto, Journal of Experimental Medicine, Vol. 193, No. 5, p. 631-636, 2001/03/05
  • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation, Asuka Suzuki,Toshikatsu Hanada,Keiichi Mitsuyama,Takafumi Yoshida,Shintaro Kamizono,Tomoaki Hoshino,Masato Kubo,Atsuko Yamashita,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira,Satoshi Matsumoto,Atsushi Toyonaga,Michio Sata,Akihiko Yoshimura, Journal of Experimental Medicine, Vol. 193, No. 4, p. 471-481, 2001/02/19
  • IκB kinase α is essential for mature B cell development and function, Tsuneyasu Kaisho,Kiyoshi Takeda,Tohru Tsujimura,Taro Kawai,Fumiko Nomura,Nobuyuki Terada,Shizuo Akira, Journal of Experimental Medicine, Vol. 193, No. 4, p. 417-426, 2001/02/19
  • Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β, E. Seki,H. Tsutsui,H. Nakano,N. M. Tsuji,K. Hoshino,O. Adachi,K. Adachi,S. Futatsugi,K. Kuida,O. Takeuchi,H. Okamura,J. Fujimoto,S. Akira,K. Nakanishi, Journal of Immunology, Vol. 166, No. 4, p. 2651-2657, 2001/02/15
  • Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation, Dominik Filipp,Kamel Alizadeh-Khiavi,Christopher Richardson,Anthony Palma,Nethnapha Paredes,Osamu Takeuchi,Shizuo Akira,Michael Julius, Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 2, p. 603-608, 2001/01/16
  • Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation, Yoshinori Kawazoe,Tetsuji Naka,Minoru Fujimoto,Hidetsugu Kohzaki,Yoshiaki Morita,Masashi Narazaki,Kohichi Okumura,Hiroshi Saitoh,Reiko Nakagawa,Yasuo Uchiyama,Shizuo Akira,Tadamitsu Kishimoto, Journal of Experimental Medicine, Vol. 193, No. 2, p. 263-269, 2001/01/15
  • Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17β-estradiol or a peroxisome proliferator, Katsumi Toda,Kiyoshi Takeda,Shizuo Akira,Toshiji Saibara,Teruhiko Okada,Saburo Onishi,Yutaka Shizuta, Journal of Steroid Biochemistry and Molecular Biology, Vol. 79, No. 1-5, p. 11-17, 2001
  • Disruption of nuclear factor-interleukin-6, a transcription factor, results in severe mycobacteria infection, Isamu Sugawara,Satoru Mizuno,Hiroyuki Yamada,Makoto Matsumoto,Shizuo Akira, American Journal of Pathology, Vol. 158, No. 2, p. 361-366, 2001
  • Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17β-oestradiol to aromatase gene (Cyp19) knockout mice, K. Toda,Okada T,K. Takeda,S. Akira,T. Saibara,M. Shiraishi,S. Onishi,Y. Shizuta, Journal of Endocrinology, Vol. 168, No. 3, p. 455-463, 2001
  • Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17β-oestradiol, K. Toda,K. Takeda,T. Okada,S. Akira,T. Saibara,T. Kaname,K. Yamamura,S. Onishi,Y. Shizuta, Journal of Endocrinology, Vol. 170, No. 1, p. 99-111, 2001
  • The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol, Cynthia A. Byrd-Leifer,Ellen F. Block,Kiyoshi Takeda,Shizuo Akira,Aihao Ding, European Journal of Immunology, Vol. 31, No. 8, p. 2448-2457, 2001
  • Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease, Takanori Kanai,Mamoru Watanabe,Akira Okazawa,Toshiro Sato,Motomi Yamazaki,Susumu Okamoto,Hiromasa Ishii,Teruji Totsuka,Ryoichi Iiyama,Ryuichi Okamoto,Masao Ikeda,Masashi Kurimoto,Kiyoshi Takeda,Shizuo Akira,Toshifumi Hibi, Gastroenterology, Vol. 121, No. 4, p. 875-888, 2001
  • Toll-like receptors control activation of adaptive immune responses, Markus Schnare,Gregory M. Barton,Agnieszka Czopik Holt,Kiyoshi Takeda,Shizuo Akira,Ruslan Medzhitov, Nature Immunology, Vol. 2, No. 10, p. 947-950, 2001
  • Enhanced gamma interferon production through activation of Vα14+ natural killer T cells by α-Galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis, K. Kawakami,Y. Kinjo,S. Yara,K. Uezu,Y. Koguchi,M. Tohyama,M. Azuma,K. Takeda,S. Akira,A. Saito, Infection and Immunity, Vol. 69, No. 11, p. 6643-6650, 2001
  • Discrimination of bacterial lipoproteins by Toll-like recepttor 6, Osamu Takeuchi,Taro Kawai,Peter F. Mühlradt,Michael Morr,Justin D. Radolf,Arturo Zychlinsky,Kiyoshi Takeda,Shizuo Akira, International Immunology, Vol. 13, No. 7, p. 933-940, 2001
  • Endotoxin-induced maturation of MyD88-deficient dendritic cells, T. Kaisho,O. Takeuchi,T. Kawai,K. Hoshino,S. Akira, Journal of Immunology, Vol. 166, No. 9, p. 5688-5694, 2001
  • Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways, S. Sato,F. Nomura,T. Kawai,O. Takeuchi,P. F. Muhlradt,K. Takeda,S. Akira, Journal of Immunology, Vol. 165, No. 12, p. 7096-7101, 2000/12/15
  • SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility, Kenjiro Inagaki,Takuji Yamao,Tetsuya Noguchi,Takashi Matozaki,Kaoru Fukunaga,Toshiyuki Takada,Tetsuya Hosooka,Shizuo Akira,Masato Kasuga, EMBO Journal, Vol. 19, No. 24, p. 6721-6731, 2000/12/15
  • A Toll-like receptor recognizes bacterial DNA, Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira, Nature, Vol. 408, No. 6813, p. 740-745, 2000/12/07
  • Erratum: Cutting Edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway (Journal of Immunology (2000) 164 (554-557)), O. Takeuchi,A. Kaufmann,K. Grote,T. Kawai,K. Hoshino,M. Morr,P. F. Muhlradt,S. Akira, Journal of Immunology, Vol. 165, No. 10, 2000/11/15
  • Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection, O. Takeuchi,K. Hoshino,S. Akira, Journal of Immunology, Vol. 165, No. 10, p. 5392-5396, 2000/11/15
  • Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88, Markus Schnare,Agnieszka Czopik Holt,Kiyoshi Takeda,Shizuo Akira,Ruslan Medzhitov, Current Biology, Current Biology Ltd, Vol. 10, No. 18, p. 1139-1142, 2000/09/21
  • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6, Hans Häcker,Ramunas M. Vabulas,Osamu Takeuchi,Katsuaki Hoshino,Shizuo Akira,Hermann Wagner, Journal of Experimental Medicine, Vol. 192, No. 4, p. 595-600, 2000/08/21
  • Cutting edge: Essential role of phospholipase C-γ2 in B cell development and function, A. Hashimoto,K. Takeda,M. Inaba,M. Sekimata,T. Kaisho,S. Ikehara,Y. Homma,S. Akira,T. Kurosaki, Journal of Immunology, Vol. 165, No. 4, p. 1738-1742, 2000/08/15
  • IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells, Kazuyoshi Kawakami,Yoshinobu Koguchi,Mahboob Hossain Qureshi,Akiko Miyazato,Satomi Yara,Yuki Kinjo,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Masashi Kurimoto,Atsushi Saito, Journal of Immunology, Vol. 165, No. 2, p. 941-947, 2000/07/15
  • Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice, Yasuji Mokuno,Tetsuya Matsuguchi,Manabu Takano,Hitoshi Nishimura,Junji Washizu,Tomohiko Ogawa,Osamu Takeuchi,Shizuo Akira,Yuji Nimura,Yasunobu Yoshikai, Journal of Immunology, Vol. 165, No. 2, p. 931-940, 2000/07/15
  • Mouse proteasomal ATPases Psmc3 and Psmc4: Genomic organization and gene targeting, Yoshimitsu Sakao,Taro Kawai,Osamu Takeuchi,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Kiyoshi Takeda,Shizuo Akira, Genomics, Vol. 67, No. 1, p. 1-7, 2000/07/01
  • Cytokine-inducing macromolecular glycolipids from enterococcus hirae: Improved method for separation and analysis of its effects on cellular activation, Masahito Hashimoto,Yoshimasa Imamura,Toshiyuki Morichika,Kazumi Arimoto,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira,Kazue Aoyama,Toshihide Tamura,Shozo Kotani,Yasuo Suda,Shoichi Kusumoto, Biochemical and Biophysical Research Communications, Vol. 273, No. 1, p. 164-169, 2000/06/24
  • Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice, Kazuyoshi Kawakami,Yoshinobu Koguchi,Mahboob Hossain Qureshi,Yuki Kinjo,Satomi Yara,Akiko Miyazato,Masashi Kurimoto,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito, FEMS Microbiology Letters, Vol. 186, No. 1, p. 121-126, 2000/05/01
  • Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection, Kazunobu Ohkusu,Tomohiro Yoshimoto,Kiyoshi Takeda,Takeharu Ogura,Shin-Ichiro Kashiwamura,Yoichiro Iwakura,Shizuo Akira,Haruki Okamura,Kenji Nakanishi, Infection and Immunity, Vol. 68, No. 5, p. 2449-2456, 2000/05
  • Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression, Fumiko Nomura,Sachiko Akashi,Yoshimitsu Sakao,Shintaro Sato,Taro Kawai,Makoto Matsumoto,Kenji Nakanishi,Masao Kimoto,Kensuke Miyake,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, American Association of Immunologists, Vol. 164, No. 7, p. 3476-3479, 2000/04/01
  • Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity, Hiroo Yokozeki,Mehran Ghoreishi,Shinsuke Takagawa,Kaoru Takayama,Takahiro Satoh,Ichiro Katayama,Kiyoshi Takeda,Shizuo Akira,Kiyoshi Nishioka, Journal of Experimental Medicine, Vol. 191, No. 6, p. 995-1004, 2000/03/20
  • Involvement of endogenously synthesized interleukin (IL)-18 in the protective effects of IL-12 against pulmonary infection with Cryptococcus neoformans in mice, Kazuyoshi Kawakami,Mahboob Hossain Qureshi,Tiantuo Zhang,Yoshinobu Koguchi,Satomi Yara,Kiyoshi Takeda,Shizuo Akira,Masashi Kurimoto,Atsushi Saito, FEMS Immunology and Medical Microbiology, Vol. 27, No. 3, p. 191-200, 2000/03
  • Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway, Osamu Takeuchi,Andreas Kaufmann,Karsten Grote,Taro Kawai,Katsuaki Hoshino,Michael Morr,Peter F. Mühlradt,Shizuo Akira, Journal of Immunology, Vol. 164, No. 2, p. 554-557, 2000/01/15
  • Signal pathways in immune systems: IL-1 R/Toll-like receptor family, Shizuo Akira, Japanese Journal of Clinical Immunology, Vol. 23, No. 6, p. 505-510, 2000
  • Critical roles of Toll-like receptors in host defense, T. Kaisho,S. Akira, Critical Reviews in Immunology, Vol. 20, No. 5, p. 393-405, 2000
  • The role of Stat3 in apoptosis and mammary gland involution, Rachel S. Chapman,Paula Lourenco,Elizabeth Tonner,David Flint,Stefan Selbert,Kyoshi Takeda,Shizuo Akira,Alan R. Clarke,Christine Watson, Advances in Experimental Medicine and Biology, Vol. 480, p. 129-138, 2000
  • Impaired water-maze performance in mice lacking transcription factor CCAAT/enhancer-binding protein β, Kazunori Yukawa,Takashi Tanaka,Ayako Toyomi,Shigekatsu Tsuji,Shizuo Akira,Hiroyuki Iso, Neuroscience Research Communications, Vol. 26, No. 1, p. 59-67, 2000/01
  • Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection, Gina M. Monteforte,Kiyoshi Takeda,Miriam Rodriguez-Sosa,Shizuo Akira,John R. David,Abhay R. Satoskar, Journal of Immunology, American Association of Immunologists, Vol. 164, No. 11, p. 5890-5893, 2000
  • Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy, Tsukasa Okuda,Kiyoshi Takeda,Yasuko Fujita,Motohiro Nishimura,Shigeki Yagyu,Makie Yoshida,Shizuo Akira,James R. Downing,Abe Tatsuo, Molecular and Cellular Biology, American Society for Microbiology, Vol. 20, No. 1, p. 319-328, 2000
  • IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice, Taku Kodama,Tomohiro Matsuyama,Kozo Kuribayashi,Yasuhiro Nishioka,Minoru Sugita,Shizuo Akira,Kenji Nakanishi,Haruki Okamura, Journal of Allergy and Clinical Immunology, Mosby Inc., Vol. 105, No. 1 I, p. 45-53, 2000
  • Caspase-1 activation of IL-1β and IL-18 are essential for Shigella flexneri-induced inflammation, Philippe J. Sansonetti,Armelle Phalipon,Josette Arondel,Kavitha Thirumalai,Subhashis Banerjee,Shizuo Akira,Kiyoshi Takeda,Arturo Zychlinsky, Immunity, Cell Press, Vol. 12, No. 5, p. 581-590, 2000
  • NF-κB activation through IKK-i-dependent I-TRAF/TANK phosphorylation, Fumiko Nomura,Taro Kawai,Kenji Nakanishi,Shizuo Akira, Genes to Cells, Vol. 5, No. 3, p. 191-202, 2000
  • Maturation of human dendritic cells by cell wall skeleton of Mycobacterium boris bacillus Calmette-Guérin: Involvement of toll-like receptors, Shoutaro Tsuji,Misako Matsumoto,Osamu Takeuchi,Shizuo Akira,Ichiro Azuma,Akira Hayashi,Kumao Toyoshima,Tsukasa Seya, Infection and Immunity, Vol. 68, No. 12, p. 6883-6890, 2000
  • The role of Toll-like receptors and MyD88 in innate immune responses, S. Akira,K. Hoshino,T. Kaisho, Journal of Endotoxin Research, Vol. 6, No. 5, p. 383-387, 2000
  • Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades, Osamu Takeuchi,Kiyoshi Takeda,Katsuaki Hoshino,Osamu Adachi,Tomohiko Ogawa,Shizuo Akira, International Immunology, Vol. 12, No. 1, p. 113-117, 2000
  • IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils, Tomohiro Yoshimoto,Hiroko Tsutsui,Kouji Tominaga,Katsuaki Hoshino,Haruki Okamura,Shizuo Akira,William E. Paul,Kenji Nakanishi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 24, p. 13962-13966, 1999/11/23
  • The absence of interleukin I receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function, Katsuaki Hoshino,Shin-Ichiro Kashiwamura,Kozo Kuribayashi,Taku Kodama,Tohru Tsujimura,Kenji Nakanishi,Tomohiro Matsuyama,Kiyoshi Takeda,Shizuo Akira, Journal of Experimental Medicine, Vol. 190, No. 10, p. 1541-1547, 1999/11/15
  • A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages, M Masumoto,T Tanaka,T Kaisho,H Sanjo,NG Copeland,DJ Gilbert,NA Jenkins,S Akira, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 163, No. 9, p. 5039-5048, 1999/11
  • Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3, Rachel S. Chapman,Paula C. Lourenco,Elizabeth Tonner,David J. Flint,Stefan Selbert,Kiyoshi Takeda,Shizuo Akira,Alan R. Clarke,Christine J. Watson, Genes and Development, Vol. 13, No. 19, p. 2604-2616, 1999/10/01
  • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components, Osamu Takeuchi,Katsuaki Hoshino,Taro Kawai,Hideki Sanjo,Haruhiko Takada,Tomohiko Ogawa,Kiyoshi Takeda,Shizuo Akira, Immunity, Vol. 11, No. 4, p. 443-451, 1999/10
  • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis, Shigetoshi Sano,Satoshi Itami,Kiyoshi Takeda,Masahito Tarutani,Yuji Yamaguchi,Hiroyuki Miura,Kunihiko Yoshikawa,Shizuo Akira,Junji Takeda, EMBO Journal, Vol. 18, No. 17, p. 4657-4668, 1999/09/01
  • Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity, Taro Kawai,Fumiko Nomura,Katsuaki Hoshino,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Shizuo Akira, Oncogene, Vol. 18, No. 23, p. 3471-3480, 1999/06/10
  • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action, Joan K. Riley,Kiyoshi Takeda,Shizuo Akira,Robert D. Schreiber, Journal of Biological Chemistry, Vol. 274, No. 23, p. 16513-16521, 1999/06/04
  • Regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300, Kazunori Yukawa,Takashi Tanaka,Shigekatsu Tsuji,Shizuo Akira, Molecular Brain Research, Vol. 69, No. 1, p. 124-134, 1999/05/21
  • Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18- gene-disrupted mice, Isamu Sugawara,Hiroyuki Yamada,Hirotaka Kaneko,Satoru Mizuno,Kiyoshi Takeda,Shizuo Akira, Infection and Immunity, Vol. 67, No. 5, p. 2585-2589, 1999/05
  • Cutting edge: Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor, Katsuaki Hoshino,Hiroko Tsutsui,Taro Kawai,Kiyoshi Takeda,Kenji Nakanishi,Yoshifumi Takeda,Shizuo Akira, Journal of Immunology, Vol. 162, No. 9, p. 5041-5044, 1999/05/01
  • TLR6: A novel member of an expanding Toll-like receptor family, O. Takeuchi,T. Kawai,H. Sanjo,N. G. Copeland,D. J. Gilbert,N. A. Jenkins,K. Takeda,S. Akira, Gene, Vol. 231, No. 1-2, p. 59-65, 1999/04
  • Limb and skin abnormalities in mice lacking IKKalpha., Takeda K,Takeuchi O,Tsujimura T,Itami S,Adachi O,Kawai T,Sanjo H,Yoshikawa K,Terada N,Akira S, Science (New York, N.Y.), Vol. 284, No. 5412, p. 313-316, 1999/04
  • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product, Katsuaki Hoshino,Osamu Takeuchi,Taro Kawai,Hideki Sanjo,Tomohiko Ogawa,Yoshifumi Takeda,Kiyoshi Takeda,Shizuo Akira, Journal of Immunology, Vol. 162, No. 7, p. 3749-3752, 1999/04
  • Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection, Javier Pizarro-Cerdá,Michel Desjardins,Edgardo Moreno,Shizuo Akira,Jean-Pierre Gorvel, Journal of Immunology, Vol. 162, No. 6, p. 3519-3526, 1999/03/15
  • IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes, Chieko Mizoguchi,Shoji Uehara,Shizuo Akira,Kiyoshi Takatsu, Journal of Immunology, Vol. 162, No. 5, p. 2812-2819, 1999/03/01
  • Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains, Taro Kawai,Hideki Sanjo,Shizuo Akira, Gene, Vol. 227, No. 2, p. 249-255, 1999/02/18
  • IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL- 18 receptor, Yasuko Hyodo,Kiyoshi Matsui,Nobuki Hayashi,Hiroko Tsutsui,Shin-Ichiro Kashiwamura,Hiroshi Yamauchi,Keisai Hiroishi,Kiyoshi Takeda,Yoh-Ichi Tagawa,Yoichiro Iwakura,Nobuhiko Kayagaki,Masashi Kurimoto,Haruki Okamura,Toshikazu Hada,Hideo Yagita,Shizuo Akira,Kenji Nakanishi,Kazuya Higashino, Journal of Immunology, Vol. 162, No. 3, p. 1662-1668, 1999/02/01
  • Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: Implications in development and function of the nervous system, Isao Oishi,Shigeto Takeuchi,Ryuju Hashimoto,Akira Nagabukuro,Takahiro Ueda,Zhao-Jun Liu,Toshihisa Hatta,Shizuo Akira,Yoichi Matsuda,Hirohei Yamamura,Hiroki Otani,Yasuhiro Minami, Genes to Cells, Blackwell Publishing Ltd., Vol. 4, No. 1, p. 41-56, 1999
  • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils, Kiyoshi Takeda,Björn E. Clausen,Tsuneyasu Kaisho,Tohru Tsujimura,Nobuyuki Terada,Irmgard Förster,Shizuo Akira, Immunity, Cell Press, Vol. 10, No. 1, p. 39-49, 1999
  • IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock, Yoshimitsu Sakao,Kiyoshi Takeda,Hiroko Tsutsui,Tsuneyasu Kaisho,Fumiko Nomura,Haruki Okamura,Kenji Nakanishi,Shizuo Akira, International Immunology, Oxford University Press, Vol. 11, No. 3, p. 471-480, 1999
  • STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells, S. Miyata,T. Matsuyama,T. Kodama,Y. Nishioka,K. Kuribayashi,K. Takeda,S. Akira,M. Sugita, Clinical and Experimental Allergy, Vol. 29, No. 1, p. 114-123, 1999
  • IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases, Takahiro Shimada,Taro Kawai,Kiyoshi Takeda,Makoto Matsumoto,Jun-Ichiro Inoue,Yoichi Tatsumi,Akihisa Kanamaru,Shizuo Akira, International Immunology, Vol. 11, No. 8, p. 1357-1362, 1999
  • Bacteria killing by macrophages via NF-IL6 gene dependent mechanism: The susceptibility to mycobacterium leprae in NF-IL6 knockout mice, Y. Yogi,M. Endoh,T. Tanaka,S. Akira,H. Okamura,H. Nomaguchi, Japanese Journal of Leprosy, Vol. 68, No. 2, p. 97-108, 1999
  • Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens, Nobuki Hayashi,Kiyoshi Matsui,Hiroko Tsutsui,Yoshio Osada,Raafat T. Mohamed,Hiroki Nakano,Shin-Ichiro Kashiwamura,Yasuko Hyodo,Kiyoshi Takeda,Shizuo Akira,Toshikazu Hada,Kazuya Higashino,Somei Kojima,Kenji Nakanishi, Journal of Immunology, Vol. 163, No. 12, p. 6702-6711, 1999
  • Unresponsiveness of MyD88-deficient mice to endotoxin, Taro Kawai,Osamu Adachi,Tomohiko Ogawa,Kiyoshi Takeda,Shizuo Akira, Immunity, Cell Press, Vol. 11, No. 1, p. 115-122, 1999
  • Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice, Hiroko Tsutsui,Nobuhiko Kayagaki,Keisuke Kuida,Hiroki Nakano,Nobuki Hayashi,Kiyoshi Takeda,Kiyoshi Matsui,Shin-Ichiro Kashiwamura,Toshikazu Hada,Shizuo Akira,Hideo Yagita,Haruki Okamura,Kenji Nakanishi, Immunity, Cell Press, Vol. 11, No. 3, p. 359-367, 1999
  • Expressions of CCAAT/enhancer-binding proteins β and δ and their activities are intensified by cAMP signaling as well as Ca2+/calmodulin kinases activation in hippocampal neurons, Kazunori Yukawa,Takashi Tanaka,Shigekatsu Tsuji,Shizuo Akira, Journal of Biological Chemistry, Vol. 273, No. 47, p. 31345-31351, 1998/11/20
  • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell- specific stat3-deficient mice, Kiyoshi Takeda,Tsuneyasu Kaisho,Nobuaki Yoshida,Junji Takeda,Tadamitsu Kishimoto,Shizuo Akira, Journal of Immunology, Vol. 161, No. 9, p. 4652-4660, 1998/11/01
  • DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis, Hideki Sanjo,Taro Kawait,Shizuo Akira, Journal of Biological Chemistry, Vol. 273, No. 44, p. 29066-29071, 1998/10/30
  • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production, Tomohiro Yoshimoto,Kiyoshi Takeda,Takashi Tanaka,Kazunobu Ohkusu,Shin-Ichiro Kashiwamura,Haruki Okamura,Shizuo Akira,Kenji Nakanishi, Journal of Immunology, Vol. 161, No. 7, p. 3400-3407, 1998/10/01
  • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice, Toshihiko Akimoto,Fumio Numata,Misato Tamura,Yoshimi Takata,Noriko Higashida,Tohru Takashi,Kiyoshi Takeda,Shizuo Akira, Journal of Experimental Medicine, Vol. 187, No. 9, p. 1537-1542, 1998/05/04
  • A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages, Takahiro Shimada,Makoto Matsumoto,Yoichi Tatsumi,Akihisa Kanamaru,Shizuo Akira, FEBS Letters, Elsevier B.V., Vol. 425, No. 3, p. 490-494, 1998/04/03
  • The nuclear factor interleukin-6 (NF-IL6) and Signal Transducer and Activator of Transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90β gene by interleukin-6 but have opposite effects on its inducibility by heat shock, Anastasis Stephanou,David A. Isenberg,Shizuo Akira,Tadamitsu Kishimoto,David S. Latchman, Biochemical Journal, Portland Press Ltd, Vol. 330, No. 1, p. 189-195, 1998/02/15
  • Loss of IL-1- and IL-18-mediated function in MyD88 knockout mice, Shizuo Akira, Japanese Journal of Clinical Immunology, Vol. 21, p. 3-12, 1998
  • Defective NK cell activity and Th1 response in IL-18-deficient mice, Kiyoshi Takeda,Hiroko Tsutsui,Tomohiro Yoshimoto,Osamu Adachi,Nobuaki Yoshida,Tadamitsu Kishimoto,Haruki Okamura,Kenji Nakanishi,Shizuo Akira, Immunity, Cell Press, Vol. 8, No. 3, p. 383-390, 1998
  • Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres, Takashi Tanaka,Tohru Tsujimura,Kiyoshi Takeda,Ayako Sugihara,Akiko Maekawa,Nobuyuki Terada,Nobuaki Yoshida,Shizuo Akira, Genes to Cells, Vol. 3, No. 12, p. 801-810, 1998
  • Defective IL-2-mediated IL-2 receptor α chain expression in Stat3-deficient T lymphocytes, Hiroshi Akaishi,Kiyoshi Takeda,Tsuneyasu Kaisho,Ryuzaburo Shineha,Susumu Satomi,Junji Takeda,Shizuo Akira, International Immunology, Vol. 10, No. 11, p. 1747-1751, 1998
  • Zip kinase, a novel serine/threonine kinase which mediates apoptosis, Taro Kawai,Makoto Matsumoto,Kiyoshi Takeda,Hideki Sanjo,Shizuo Akira, Molecular and Cellular Biology, American Society for Microbiology, Vol. 18, No. 3, p. 1642-1651, 1998
  • Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function, Osamu Adachi,Taro Kawai,Kiyoshi Takeda,Makoto Matsumoto,Hiroko Tsutsui,Masafumi Sakagami,Kenji Nakanishi,Shizuo Akira, Immunity, Cell Press, Vol. 9, No. 1, p. 143-150, 1998
  • Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene, Takashi Tanaka,Nobuaki Yoshida,Tadamitsu Kishimoto,Shizuo Akira, EMBO Journal, Vol. 16, No. 24, p. 7432-7443, 1997/12/15
  • Structure and function of a new STAT-induced STAT inhibitor, Tetsuji Naka,Masashi Narazaki,Moritoshi Hirata,Tomoshige Matsumoto,Seijiro Minamoto,Atsufumi Aono,Norihiro Nishimoto,Tadahiro Kajita,Tetsuya Taga,Kazuyuki Yoshizaki,Shizuo Akira,Tadamitsu Kishimoto, Nature, Vol. 387, No. 6636, p. 924-929, 1997/06/26
  • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality, Kiyoshi Takeda,Koichi Noguchi,Wei Shi,Takashi Tanaka,Makoto Matsumoto,Nobuaki Yoshida,Tadamitsu Kishimoto,Shizuo Akira, Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 8, p. 3801-3804, 1997/04/15
  • The Amino Acid Residues Immediately Carboxyl-terminal to the Tyrosine Phosphorylation Site Contribute to Interleukin 6-specific Activation of Signal Transducer and Activator of Transcription 3, Masahiro Inoue,Masashi Minami,Makoto Matsumoto,Tadamitsu Kishimoto,Shizuo Akira, Journal of Biological Chemistry, American Society for Biochemistry & Molecular Biology (ASBMB), Vol. 272, No. 14, p. 9550-9555, 1997/04/04
  • Signal transducer and activator of transcription protein (STAT): Its relation to Th1/Th2-mediated diseases, Kiyoshi Takeda,Tadamitsu Kishimoto,Shizuo Akira, Nutrition, Vol. 13, No. 11-12, p. 987-988, 1997
  • Interleukin 6 activates heat-shock protein 90β gene expression, A. Stephanou,V. Amin,D. A. Isenberg,S. Akira,T. Kishimoto,David S. Latchman, Biochemical Journal, Portland Press Ltd, Vol. 321, No. 1, p. 103-106, 1997/01/01
  • Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor, Shogo Kurebayashi,Yoshihiro Miyashita,Takahisa Hirose,Soji Kasayama,Shizuo Akira,Tadamitsu Kishimoto, Journal of Steroid Biochemistry and Molecular Biology, Vol. 60, No. 1-2, p. 11-17, 1997/01
  • NF-IL6 and NF-κB in cytokine gene regulation, Shizuo Akira,Tadamitsu Kishimoto, Advances in Immunology, Academic Press Inc., Vol. 65, p. 1-46, 1997
  • Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells, Makoto Matsumoto,Masashi Minami,Kiyoshi Takeda,Yoshimitsu Sakao,Shizuo Akira, FEBS Letters, Elsevier B.V., Vol. 395, No. 2-3, p. 143-147, 1996/10/21
  • Impaired IL-13-Mediated Functions of Macrophages in STAT6-Deficient Mice, Kiyoshi Takeda,Masahito Kamanaka,Takashi Tanaka,Tadamitsu Kishimoto,Shizuo Akira, Journal of Immunology, Vol. 157, No. 8, p. 3220-3222, 1996/10/15
  • Differential utilization of Janus kinase-signal transducer and activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-α, Cheng-Rong Yu,Jian-Xin Lin,Donald W. Fink,Shizuo Akira,Eda T. Bloom,Akira Yamauchi, Journal of Immunology, Vol. 157, No. 1, p. 126-137, 1996/07/01
  • Overexpression of a reversion-related protein in the revertant RR cells, Dinggan Liu,Zaiping Li,Shizuo Akira,Tadamitsu Kishimoto, Science in China, Series C: Life Sciences, Vol. 39, No. 3, p. 300-309, 1996/06
  • STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line., M. Minami,M. Inoue,S. Wei,K. Takeda,M. Matsumoto,T. Kishimoto,S. Akira, Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 93, No. 9, p. 3963-3966, 1996/04/30
  • Identification of alternative splicing form of stat2, Tetsuya Sugiyama,Yukihiro Nishio,Tadamitsu Kishimoto,Shizuo Akira, FEBS Letters, Elsevier B.V., Vol. 381, No. 3, p. 191-194, 1996/03/04
  • Essential role of Stat6 in IL-4 signalling, H. Takeda,T. Tanaka,W. Shi,M. Matsumoto,M. Minami,S. I. Kashiwamura,K. Nakanishi,N. Yoshida,T. Kishimoto,S. Akira, Nature, Vol. 380, No. 6575, p. 627-630, 1996
  • The genomic structure and chromosomal localization of the mouse STAT3 gene, Wei Shi,Masahiro Inoue,Masashi Minami,Kiyoshi Takeda,Makoto Matsumoto,Yoichi Matsuda,Tadamitsu Kishimoto,Shizuo Akira,T. Watanabe, International Immunology, Oxford University Press (OUP), Vol. 8, No. 8, p. 1205-1211, 1996
  • Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages, Takashi Tanaka,Shizuo Akira,Kanji Yoshida,Masanori Umemoto,Yoshihiro Yoneda,Naoki Shirafuji,Hiroshi Fujiwara,Sachiko Suematsu,Nobuaki Yoshida,Tadamitsu Kishimoto, Cell, Vol. 80, No. 2, p. 353-361, 1995/01/27
  • Cytokine Signal Transduction through a Homo‐or Heterodimer of gp130, TADAMITSU KISHIMOTO,TAKASHI TANAKA,KAMJI YOSHIDA,SHIZUO AKIRA,TETSUYA TAGA, Annals of the New York Academy of Sciences, Vol. 766, No. 1, p. 224-234, 1995
  • Targeted Disruption of the IL‐6 Related Genes: gp130 and NF‐IL‐6, SHIZUO AKIRA,KANJI YOSHIDA,TAKASHI TANAKA,TETSUYA TAGA,TADAMITSU KISHIMOTO, Immunological Reviews, Vol. 148, No. 1, p. 221-253, 1995
  • Transcription Factors NF‐IL6 and APRF Involved in gp130‐mediated Signaling Pathway, S. AKIRA,Y. NISHIO,T. TANAKA,M. INOUE,T. MATSUSAKA,X. ‐J WANG,S. WEI,N. YOSHIDA,T. KISHIMOTO, Annals of the New York Academy of Sciences, Vol. 762, No. 1, p. 15-28, 1995
  • Identification of a Transcriptional Regulatory Factor for Human Aromatase Cytochrome P450 Gene Expression as Nuclear Factor Interleukin‐6 (NF‐IL6), a Member of the CCAAT/Enhancer‐Binding Protein Family, Katsumi Toda,Shizuo Akira,Tadamitsu Kishimoto,Hiroshi Sasaki,Kozo Hashimoto,Yasutake Yamamoto,Yusuke Sagara,Yutaka Shizuta, European Journal of Biochemistry, Vol. 231, No. 2, p. 292-299, 1995
  • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway, Shizuo Akira,Yukihiro Nishio,Masahiro Inoue,Xue-Jie Wang,Shi We,Taiji Matsusaka,Kanji Yoshida,Tetsuo Sudo,Masanobu Naruto,Tadamitsu Kishimoto, Cell, Elsevier BV, Vol. 77, No. 1, p. 63-71, 1994/04
  • Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8, Taiji Matsusaka,Keiko Fujikawa,Yukihiro Nishio,Naofumi Mukaida,Kouji Matsushima,Tadamitsu Kishimoto,Shizuo Akira, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 90, No. 21, p. 10193-10197, 1993/11/01
  • Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6, Toshihiro Nakajima,Shigemi Kinoshita,Tatsuru Sasagawa,Koichi Sasaki,Masanobu Naruto,Tadamitsu Kishimoto,Shizuo Akira, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 90, No. 6, p. 2207-2211, 1993/03/15
  • A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat α1-acid glycoprotein gene via direct protein-protein interaction, H. Nishio,H. Isshiki,T. Kishimoto,S. Akira, Molecular and Cellular Biology, Vol. 13, No. 3, p. 1854-1862, 1993
  • Interleukin-6 in biology and medicine, Shizuo Akira,Tetsuya Taga,Tadamitsu Kishimoto, Advances in Immunology, Academic Press Inc., Vol. 54, p. 1-78, 1993
  • A member of the C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6, Shigemi Kinoshita,Shizuo Akira,Tadamitsu Kishimoto, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 89, No. 4, p. 1473-1476, 1992/02/15
  • Mechanisms of soluble mediators, Shizuo Akira,Tadamitsu Kishimoto, Current Opinion in Immunology, Vol. 4, No. 3, p. 307-313, 1992
  • IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection, Shizuo Akira,Tadamitsu Kishimoto†, Immunological Reviews, Vol. 127, No. 1, p. 25-50, 1992
  • IL-6 receptor and mechanism of signal transduction, Tadamitsu Kishimoto,Shizuo Akira,Tetsuya Taga, International Journal of Immunopharmacology, Vol. 14, No. 3, p. 431-438, 1992
  • Interleukin-6 and its receptor: A paradigm for cytokines, Tadamitsu Kishimoto,Shizuo Akira,Tetsuya Taga, Science, Vol. 258, No. 5082, p. 593-597, 1992
  • Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6, Shunji Natsuka,Hiroshi Isshiki,Shizuo Akira,Tadamitsu Kishimoto, FEBS Letters, Vol. 291, No. 1, p. 58-62, 1991/10/07
  • Age-associated increase in interleukin 6 in MRL/lpr mice, Bo Tang,Tadashl Matsuda,Shizuo Akira,Norikazu Nagata,Susumu Ikehara,Toshio Hirano,Tadamitsu Kishimoto, International Immunology, Vol. 3, No. 3, p. 273-278, 1991
  • Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene, Hiroshi Isshiki,Shizuo Akira,Osamu Tanabe,Toshihiro Nakajima,Takuya Shimamoto,Toshio Hirano,Tadamitsu Kishimoto, Molecular and Cellular Biology, American Society for Microbiology, Vol. 10, No. 6, p. 2757-2764, 1990
  • A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family, S. Akira,H. Isshiki,T. Sugita,O. S. Tanabe Kinoshita,Y. Nishio,T. Nakajima,T. Hirano,T. Kishimoto, EMBO Journal, Vol. 9, No. 6, p. 1897-1906, 1990
  • Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF), Shizuo Akira,Toshio Hirano,Tetsuya Taga,Tadamitsu Kishimoto, FASEB Journal, Vol. 4, No. 11, p. 2860-2867, 1990
  • IgG1 plasmacytosis in interleukin 6 transgenic mice, S. Suematsu,T. Matsuda,K. Aozasa,S. Akira,N. Nakano,S. Ohno,J. Miyazaki,K. Yamamura,T. Hirano,T. Kishimoto, Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 19, p. 7547-7551, 1989
  • Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human, O. Tanabe,S. Akira,T. Kamiya,G. G. Wong,T. Hirano,T. Kishimoto, Journal of Immunology, Vol. 141, No. 11, p. 3875-3881, 1988
  • Two pairs of recombination signals are sufficient to cause immunoglobulin V-(d)-J joining, Shizuo Akira,Kenji Okazaki,Hitoshi Sakano, Science, Vol. 238, No. 4830, p. 1134-1138, 1987
  • Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell lines, H. Kikutani,T. Taga,S. Akira,H. Kishi,Y. Miki,O. Saiki,Y. Yamamura,T. Kishimoto, Journal of Immunology, Vol. 134, No. 2, p. 990-995, 1985
  • Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice, Ken-Ichi Yamamura,Hitoshi Kikutani,Virginia Folsom,Linda K. Clayton,Masao Kimoto,Shizuo Akira,Shin-Ichiro Kashiwamura,Susumu Tonegawa,Tadamitsu Kishimoto, Nature, Vol. 316, No. 6023, p. 67-69, 1985
  • Introduction of human γ1 immunoglobulin genes into fertilized mouse eggs, Ken-Ichi Yamamura,Hitoshi Kikutani,Naoki Takahashi,Tetsuya Taga,Shizuo Akira,Kazuhiko Kawai,Kenichiro Fukuchi,Yuichi Kumahara,Tasuku Honjo,Tadamitsu Kishimoto, Journal of Biochemistry, Oxford University Press, Vol. 96, No. 2, p. 357-363, 1984
  • Isotype switching in murine pre-B cell lines, Shizuo Akira,Haruo Sugiyama,Nobuaki Yoshida,Hitoshi Kikutani,Yuichi Yamamura,Tadamitsu Kishimoto, Cell, Vol. 34, No. 2, p. 545-556, 1983
  • Functional V region formation during in vitro culture of a murine immature B precursor cell line, Haruo Sugiyama,Shizuo Akira,Hitoshi Kikutani,Susumu Kishimoto,Yuichi Yamamura,Tadamitsu Kishimoto, Nature, Vol. 303, No. 5920, p. 812-815, 1983
  • Relationship between the rearrangement of immunoglobulin genes, the appearance of a B lymphocyte antigen, and immunoglobulin synthesis in murine pre-B cell lines, H. Sugiyama,S. Akira,N. Yoshida,S. Kishimoto,Y. Yamamura,P. Kincade,T. Honjo,T. Kishimoto, Journal of Immunology, Vol. 128, No. 6, p. 2793-2797, 1982

Misc.

  • 皮膚科疾患における転写因子BATFファミリーの意義とその応用, 金丸 央,佐藤 荘,福島 聡,尹 浩信,審良 静男, 日本皮膚科学会雑誌, (公社)日本皮膚科学会, Vol. 129, No. 5, p. 1228-1228, 2019/05
  • mPGES-1阻害薬のマウス脳梗塞障害改善機序, 宿利 美香,大内 彩子,内藤 康仁,岩井 孝志,渡辺 俊,尾山 実砂,植松 智,審良 静男,Jakobsson Per-Johan,田辺 光男,松尾 由理, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 138年会, No. 3, p. 95-95, 2018/03
  • RBM7によるnon-coding RNA分解を介した臓器線維化制御, 福島 清春,佐藤 荘,木田 博,熊ノ郷 淳,審良 静男, 日本呼吸器学会誌, (一社)日本呼吸器学会, Vol. 7, No. 増刊, p. 146-146, 2018/03
  • 肺線維症進展に関わる新規分子標的の同定, 福島 清春,佐藤 荘,木田 博,熊ノ郷 淳,審良 静男, 日本内科学会雑誌, (一社)日本内科学会, Vol. 107, No. Suppl., p. 217-217, 2018/02
  • Type I IFN signaling induces Th17 cells capable of promoting gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector, Masahisa Hemmi,Masashi Tachibana,Natsuki Fujimoto,Masaki Shoji,Fuminori Sakurai,Kouji Kobiyama,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 100, p. 150-150, 2017/12
  • Introduction: Dynamics of RNA Regulation in the Immune System Special Issue, Shizuo Akira,Kazuhiko Maeda, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 29, No. 4, p. 145-147, 2017/04
  • Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells, Kazuhiko Maeda,Shizuo Akira, INTERNATIONAL IMMUNOLOGY, OXFORD UNIV PRESS, Vol. 29, No. 4, p. 149-155, 2017/04
  • マウス脳出血モデルにおける膜結合型PGE2合成酵素-1の役割, 松尾 由理,與澤 智佳,川野 早紀,水口 愛香,植松 智,審良 静男,内藤 康仁,渡辺 俊,岩井 孝志,田辺 光男, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 137年会, No. 3, p. 69-69, 2017/03
  • トポテカンによる細胞死を介したDNA内包エクソソームの放出とSTING依存的がん免疫誘導機構の解明, 鍛代悠一,鍛代悠一,川崎拓実,末吉拓也,小檜山康司,石井健,雛健,審良静男,松田正,河合太郎, 日本薬学会年会要旨集(CD-ROM), Vol. 137th, 2017
  • 自然免疫による癌細胞DNAの認識と抗腫瘍免疫発動機構の解析, 鍛代悠一,雛健,川崎拓実,末吉拓也,小檜山康司,石井健,審良静男,松田正,河合太郎, 日本Cell Death学会学術集会プログラム抄録集, Vol. 25th, 2016
  • Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明, 鍛代悠一,織大祐,末吉拓也,川崎拓実,竹内理,松田正,審良静男,河合太郎, 日本薬学会年会要旨集(CD-ROM), Vol. 136th, 2016
  • 尿酸塩結晶による炎症惹起の分子機序, 三澤拓馬,審良静男,齊藤達哉, 高尿酸血症と痛風, Vol. 23, No. 2, p. 20-26, 2015/09
  • NLRP3インフラマソームと痛風関節炎, 三澤拓馬,齊藤達哉,審良静男, 痛風と核酸代謝, Vol. 39, No. 1, p. 1-6, 2015/07
  • C/EBP beta controls mucosal fungal immunity through regulation of beta-defensins, Michelle Simpson-Abelson,Erin Childs,Shrinivas Bishu,Norma Solis,Satoshi Uematsu,Heather Conti,Shizuo Akira,Scott Filler,Sarah Gaffen, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 194, 2015/05
  • インフラマソームの活性化機構, 三澤拓馬,審良静男,齊藤達哉, 臨床免疫・アレルギー科, Vol. 63, No. 5, p. 489-494, 2015/05
  • 微小管によるミトコンドリアの局在制御がNLRP3インフラマソームの活性化を促進する, 三澤拓馬,審良静男,齊藤達哉, 細胞工学, Vol. 34, No. 6, p. 567-570, 2015/05
  • Neutrophils Modulate Osteoblastic Niche for Hematopoietic Progenitors Via Prostaglandin E2 Production Triggered By Sympathetic Nervous System, Yuko Kawano,Chie Fukui,Kanako Wakahashi,Shinichi Ishii,Tomohide Suzuki,Mari Sato,Noboru Asada,Hiroki Kawano,Kentaro Minagawa,Akiko Sada,Satoshi Uematsu,Shizuo Akira,Toshimitsu Uede,Shuh Narumiya,Toshimitsu Matsui,Yoshio Katayama, BLOOD, AMER SOC HEMATOLOGY, Vol. 124, No. 21, 2014/12
  • TLRおよびNLRを介した自然免疫応答, 齊藤達哉,審良静男, 実験医学, Vol. 32, No. 17, p. 76-82, 2014/10
  • TRIF signaling is essential for TLR4-driven IgE class switching, Erin Janssen,Esra Ozcan,Kyriaki Liadaki,Haifa Jabara,John Manis,Sumana Ullas,Shizuo Akira,Katherine Fitzgerald,Douglas Golenbock,Raif Geha, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 192, 2014/05
  • Type I IFN Signaling Induced By Systemically Administrated Adenovirus Vector Promotes the Antigen-Specific Mucosal Immunity, Masahisa Henmi,Masashi Tachibana,Sayaka Tsuzuki,Masaki Shoji,Fuminori Sakurai,Koji Kobiyama,Ken J. Ishii,Shizuo Akira,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 22, p. S272-S272, 2014/05
  • NLRP3インフラマソーム活性化における微小管の関与, 三澤拓馬,齊藤達哉,審良静男, 臨床免疫・アレルギー科, Vol. 61, No. 4, p. 457-461, 2014/04
  • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production (vol 11, pg 63, 2010), Hendrik Poeck,Michael Bscheider,Olaf Gross,Katrin Finger,Susanne Roth,Manuele Rebsamen,Nicole Hannesschlager,Martin Schlee,Simon Rothenfusser,Winfried Barchet,Hiroki Kato,Shizuo Akira,Satoshi Inoue,Stefan Endres,Christian Peschel,Gunther Hartmann,Veit Hornung,Juergen Ruland, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 15, No. 1, p. 109-109, 2014/01
  • Induction of Microsomal prostaglandin E synthase-1 expression contributes to increase in prostaglandin E-2 production in the hemorrhagic brain, Chika Yozawa,Saki Kawano,Yasuhito Naito,Shun Watanabe,Takashi Iwai,Satoshi Uematsu,Shizuo Akira,Mitsuo Tanabe,Yuri Ikeda-Matsuo, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 124, p. 149P-149P, 2014
  • Arl5BによるMDA5依存的な自然免疫シグナルの抑制機構の解明, 鍛代悠一,織大祐,末吉拓也,村瀬本弥,川崎拓実,竹内理,審良静男,河合太郎, 日本分子生物学会年会プログラム・要旨集(Web), Vol. 37th, 2014
  • Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors, Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii, Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology, Elsevier Inc., p. 3-41, 2013/11
  • NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (vol 110, pg 3372, 2007), Sinead M. Miggin,Eva Palsson-McDermott,Aisling Dunne,Caroline Jefferies,Emmanuel Pinteaux,Kathy Banahan,Caroline Murphy,Paul Moynagh,Masahiro Yamamoto,Shizuo Akira,Nancy Rothwell,Douglas Golenbock,Katherine A. Fitzgerald,Luke A. J. O'Neill, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 110, No. 43, p. 17600-17600, 2013/10
  • 自然免疫と痛風関節炎, 齊藤達哉,三澤拓馬,審良静男, 高尿酸血症と痛風, Vol. 21, No. 2, p. 14-18, 2013/10
  • Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia, Sebok K. Halder,Hayato Matsunaga,Ken J. Ishii,Shizuo Akira,Kensuke Miyake,Hiroshi Ueda, Journal of Neurochemistry, Vol. 126, No. 2, p. 243-260, 2013/07
  • MRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1, Takuya Uehata,Shizuo Akira, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1829, No. 6-7, p. 708-713, 2013/06
  • 微小管を介したミトコンドリアの局在変化はNLRP3インフラマソームの活性化を促進する, 齊藤達哉,三澤拓馬,審良静男, 分子消化器病, Vol. 10, No. 2, p. 99-102, 2013/06
  • Intestinal Lin-c-Kit+NKp46-CD4-population highly produces IL-22 upon IL-1 beta stimulation, Youngae Lee,Yutaro Kumagai,Min Seong Jang,Jung-Hwan Kim,Bo-Gie Yang,Shizuo Akira,Myoung Ho Jang, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, 2013/05
  • Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response, Young Kang,Jianhui Ma,Eun-Jin Shim,Jiawei Lu,So-Young Eun,Mick Croft,Peter Tobias,Osamu Takeuchi,Shizuo Akira,Jiahuai Han,Michael Karin, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 190, 2013/05
  • Prostaglandin E2 Regulates Osteoblastic Niche Selectively for Hematopoietic Progenitors through Induction of Osteopontin via EP4 Receptor, Yuko Kawano,Mari Sato,Noboru Asada,Chie Fukui,Kanako Wakahashi,Hiroki Kawano,Kentaro Minagawa,Akiko Sada,Satoshi Uematsu,Shizuo Akira,Toshimitsu Uede,Shuh Narumiya,Toshimitsu Matsui,Yoshio Katayama, JOURNAL OF BONE AND MINERAL RESEARCH, WILEY-BLACKWELL, Vol. 28, 2013/02
  • Microsomal prostaglandin E synthase-1 contributes to dopaminergic neurodegeneration in a 6-OHDA lesioned mouse, Yuri Ikeda-Matsuo,Tomoko Mizoguchi,Yasuhito Naito,Satoshi Uematsu,Shizuo Akira,Mitsuo Tanabe,Yasuharu Sasaki, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 121, p. 221P-221P, 2013
  • Neutrophil Extracellular TrapsによるHuman Immunodeficiency Virus-1に対する感染防御, 齊藤達哉,審良静男, 感染・炎症・免疫, Vol. 43, p. 63-65, 2013
  • Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin e receptor 3 (PTGER3) genes, Mayumi Ueta,Gen Tamiya,Katsushi Tokunaga,Chie Sotozono,Masao Ueki,Hiromi Sawai,Tsutomu Inatomi,Toshiyuki Matsuoka,Shizuo Akira,Shuh Narumiya,Kei Tashiro,Shigeru Kinoshita, Journal of Allergy and Clinical Immunology, Vol. 129, No. 5, p. 1413-1416, 2012/05
  • Intestinal mast cell progenitors function as innate lymphoid cells, Youngae Lee,Taro Kumagai,Shizuo Akira,Myoung Ho Jang, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 188, 2012/05
  • Type-I IFN Signaling Is Required for the Induction of Antigen-Specific CD8+T Cell Responses by Adenovirus Vector Vaccine in the Gut-Mucosal Compartment, Masashi Tachibana,Masaki Shoji,Kazufumi Katayama,Kyoko Tomita,Sayaka Tsuzuki,Fuminori Sakurai,Kenji Kawabata,Shizuo Akira,Ken J. Ishii,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 20, p. S257-S257, 2012/05
  • Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response, Ryutaro Fukui,Shin-Ichiroh Saitoh,Atsuo Kanno,Masahiro Onji,Takuma Shibata,Akihiko Ito,Morikazu Onji,Mitsuru Matsumoto,Shizuo Akira,Nobuaki Yoshida,Kensuke Miyake, ARTHRITIS RESEARCH & THERAPY, BIOMED CENTRAL LTD, Vol. 14, 2012
  • Role of neutrophilic mPGES-1 in stroke injury, Yuri Ikeda-Matsuo,Yuri Hirayama,Satoshi Uematsu,Shizuo Akira,Mitsuo Tanabe,Yasuharu Sasaki, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 118, p. 149P-149P, 2012
  • The role of mRNA degradation in immunity and inflammation, Shizuo Akira, ARTHRITIS RESEARCH & THERAPY, BIOMED CENTRAL LTD, Vol. 14, 2012
  • Jdp2 is indispensable for the normal differentiation of osteoclasts and neutrophils, Kenta Maruyama,Shizuo Akira, First Author’s (Web page), Database Center for Liife Science, Reseach Organization of Infromation and Systems, 2012
  • Nuclear receptor PPAR-gamma interacts with IRF7 to negatively regulate TLR7/9-mediated type I interferon production and the development of murine lupus, Barry Ripley,Minoru Fujimoto,Amy Han,David Millrine,Soyoung Lee,Taro Kawai,Shizuo Akira,Tetsuji Naka,Tadamitsu Kishimoto, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 56, No. 1, p. 22-22, 2011/10
  • Innate immunity and adjuvants, Shizuo Akira, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, ROYAL SOC, Vol. 366, No. 1579, p. 2748-2755, 2011/10
  • オートファジーとインフラマソーム, 齊藤達哉,審良静男, 生体の科学, Vol. 62, No. 3, p. 237-244, 2011/06
  • 抗ウイルス因子Viperinは形質細胞様樹状細胞におけるTLR7およびTLR9を介したI型インターフェロンの産生を促進する, 齊藤達哉,審良静男, ライフサイエンス 新着論文レビュー(オンライン出版)http://first.lifesciencedb.jp/archives/2794#more-2794, 2011/05
  • The protective role of TLR6 during experimental fungal asthma is mediated by IL-23 and IL-17A, Ana Moreira,Karen Cavassani,Rikki Hullinger,Darryl Knight,Steven Kunkel,Satoshi Uematsu,Shizuo Akira,Cory Hogaboam, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, 2011/04
  • TNF-alpha produced by inflammatory DCs as a molecular switch in Th17/Th2 and neutrophilic/eosinophilic responses during persistent fungal infection, Mingjian Fei,Shikha Bhatia,Timothy Oriss,Manohar Yarlagadda,Anupriya Khare,Shizuo Akira,Yoichiro Iwakura,Prabir Ray,Jay Kolls,Anuradha Ray, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 186, 2011/04
  • ダニ抗原誘発マウス気管支喘息発症におけるTLR9の意義, 田中 宏幸,升田 雄士,江崎 友哉,村田 健司,山下 弘高,植松 智,審良 静男,稲垣 直樹,永井 博弌, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 131年会, No. 3, p. 80-80, 2011/03
  • High Speed Resolution Enhancement by Optical Pupil Function Modulating System, Tomonobu M. Watanabe,Yoshikazu Tsukasaki,Tatsuya Saitoh,Shizuo Akira,Toshio Yanagida, BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 100, No. 3, p. 356-356, 2011/02
  • Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM, Lijian Wang,Estela Trebicka,Ying Fu,Lisa Waggoner,Shizuo Akira,Katherine A. Fitzgerald,Jonathan C. Kagan,Bobby J. Cherayil, JOURNAL OF INNATE IMMUNITY, KARGER, Vol. 3, No. 5, p. 437-446, 2011
  • NEGATIVE REGULATION OF TOLL-LIKE RECEPTOR MEDIATED IMMUNE RESPONSES, Shizuo Akira, JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Vol. 12, No. 12, p. 1015-1016, 2010/12
  • Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin-6 Expression via Toll-Like Receptor 2 Pathway in Adipocytes in vitro and in vivo, Yasuko Abe,Akio Kawakami,Satoshi Uematsu,Shizuo Akira,Kentaro Shimokado,Frank Sacks,Masayuki Yoshida, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 122, No. 21, 2010/11
  • Conditional ablation of Ubc13 in keratinocytes induces abnormal differentiation, decreased proliferation, and apoptosis, Koji Sayama,Yuji Shirakata,Yasushi Hanakawa,Satoshi Hirakawa,Xiuju Dai,Masahiro Yamamoto,Shizuo Akira,Koji Hashimoto, JOURNAL OF DERMATOLOGY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 37, p. 33-33, 2010/09
  • 移植片対宿主病におけるSTAT3の役割に関する発生工学的手法を用いた検討, 松 春子,尾崎 勝俊,畑中 恵子,多々良 礼音,目黒 明子,翁 家国,佐藤 一也,森 政樹,鈴木 隆浩,室井 一男,永井 正,植松 智,審良 静男,小澤 敬也, 臨床血液, (一社)日本血液学会-東京事務局, Vol. 51, No. 9, p. 1097-1097, 2010/09
  • 多発性硬化症における膜型プロスタグランジンE合成酵素(mPGES-1)の修飾作用(Moduratory effect of Microsomal prostaglandin E synthase-1 on multiple sclerosis), 竹宮 孝子,竹内 千仙,松本 陽,神山 邦子,植松 智,審良 静男,山形 要人,文沢 久美子, 神経化学, 日本神経化学会, Vol. 49, No. 2-3, p. 586-586, 2010/08
  • 膜結合型プロスタグランジンE合成酵素の誘導はマウス及びラット培養中脳神経細胞の6-ハイドロキシドパミンによるドパミン神経細胞死に寄与する(Induction of microsomal prostaglandin E synthase-1 contributes to dopaminergic neuronal death in rats and mice mesencephalic neuronal culture treated with 6-hydroxydopamine), 松尾 由理,溝口 智子,植松 智,審良 静男,佐々木 泰治, 神経化学, 日本神経化学会, Vol. 49, No. 2-3, p. 668-668, 2010/08
  • インフラマソームを介した炎症性サイトカインIL-1betaの産生, 齊藤達哉,審良静男, 医学のあゆみ, Vol. 234, No. 5, p. 379-385, 2010/07
  • インフラマソームによる炎症性サイトカインIL-1betaの産生制御, 齊藤達哉,審良静男, 実験医学, Vol. 28, No. 12, p. 1869-1873, 2010/07
  • C/EBP-beta and PPAR-alpha Coordinately Regulate Cardiac Metabolic Genes in Response to a Fatty Acid-Load, Jinya Suzuki,Miki Fujii,Masami Ueno,Tomoko Kimura,Michiko Imagawa,Sadao Takahashi,Hideki Kimura,Satoshi Uematsu,Shizuo Akira,Fredric B. Kraemer,Isamu Miyamori, DIABETES, AMER DIABETES ASSOC, Vol. 59, p. A425-A426, 2010/06
  • Regulation of dsDNA-induced innate immune responses by membrane trafficking, Tatsuya Saitoh,Naonobu Fujita,Tamotsu Yoshimori,Shizuo Akira, Autophagy, Taylor and Francis Inc., Vol. 6, No. 3, p. 430-432, 2010/04/01
  • OP-047-1 Poly I: C-induced anti-tumor effect of NK cells in CD8α^+dendritic cells via the IPS-1 and TRIF-dependent pathways(免疫-3,一般口演,第110回日本外科学会定期学術集会), 三宅 亨,加藤 博己,竹内 理,審良 静男,谷 徹, 日本外科学会雑誌, 一般社団法人日本外科学会, Vol. 111, No. 2, 2010/03/05
  • Prostaglandin E2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation, J. A. Boyce,S. Nallamshetty,W. Xing,T. Laidlaw,C. Feng,S. Uematsu,S. Akira,A. Lundequist, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 125, No. 2, p. AB62-AB62, 2010/02
  • LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses, Takashi Satoh,Hiroki Kato,Yutaro Kumagai,Mitsutoshi Yoneyama,Shintaro Sato,Kazufumi Matsushita,Tohru Tsujimura,Takashi Fujita,Shizuo Akira,Osamu Takeuchi, Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 4, p. 1512-1517, 2010/01/26
  • Endothelial microsomal prostaglandin E synthase-1 regulates activation of astrocytes via EP3 receptor, Takako Takemiya,Kiyoshi Matsumura,Hiroko Sugiura,Michiyo Maehara,Shin Yasuda,Satoshi Uematsu,Shizuo Akira,Kanato Yamagata, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 112, p. 189P-189P, 2010
  • Induction of microsomal prostaglandin E synthase-1 contributes to dopaminergic neuronal death in rats and mice mesencephalic neuronal culture treated with 6-hydroxydopamine, Yuri Ikeda-Matsuo,Tomoko Mizoguchi,Satoshi Uematsu,Shizuo Akira,Yasuharu Sasaki, NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Vol. 68, p. E306-E306, 2010
  • 6-OHDA投与マウスパーキンソン病モデルにおいてmPGES-1は障害増悪に寄与する, 溝口 智子,松尾 由理,植松 智,審良 静男,佐々木 泰治, 日本薬理学雑誌, (公社)日本薬理学会, Vol. 135, No. 1, p. 10P-10P, 2010/01
  • 自然免疫と自己免疫疾患, 松下 一史,竹内 理,審良 静男, 炎症と免疫, (株)先端医学社, Vol. 18, No. 1, p. 69-74, 2009/12
  • Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet, Nada Pejnovic,Athanassios Vratimos,Sang Hee Lee,Dusan Popadic,Kiyoshi Takeda,Shizuo Akira,Woon Ling Chan, Molecular Immunology, Vol. 47, No. 1, p. 37-45, 2009/11
  • TLR-independent signaling pathway in the production of IFN-b by replication-incompetent adenovirus vectors, Tomoko Yamaguchi,Kenji Kawabata,Ken Ishii,Fuminori Sakurai,Shizuo Akira,Hiroyuki Mizuguchi, HUMAN GENE THERAPY, MARY ANN LIEBERT INC, Vol. 20, No. 11, p. 1476-1476, 2009/11
  • オートファジーと自然免疫, 齊藤達哉,審良静男, 臨床検査, Vol. 53, No. 12, p. 1562-1568, 2009/11
  • Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity, Takahiro Nagatake,Satoshi Fukuyama,Dong-Young Kim,Kaoru Goda,Osamu Igarashi,Shintaro Sato,Tomonori Nochi,Hiroshi Sagara,Yoshifumi Yokota,Anton M. Jetten,Tsuneyasu Kaisho,Shizuo Akira,Hitomi Mimuro,Chihiro Sasakawa,Yoshinori Fukui,Kohtaro Fujihashi,Taishin Akiyama,Jun-ichiro Inoue,Josef M. Penninger,Jun Kunisawa,Hiroshi Kiyono, The Journal of Experimental Medicine, Rockefeller University Press, Vol. 206, No. 11, p. 2351-2364, 2009/10/26
  • Tank is a negative regulator of TLR signaling and critical for preventing autoimmune nephritis, Osamu Takeuchi,Tatsukata Kawagoe,Shizuo Akira, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 20-20, 2009/10
  • Zc3h12a, a negative regulator in the TLR response, Shizuo Akira, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 48, No. 1-2, p. 4-4, 2009/10
  • オートファジーと免疫, 齊藤達哉,審良静男, 実験医学, Vol. 27, No. 18, p. 2969-2974, 2009/10
  • 実験的自己免疫性脳脊髄炎におけるPGE2合成酵素の役割, 木原 泰行,石井 聡,北 芳博,松下 拓也,植松 智,審良 静男,吉良 潤一,清水 孝雄, 日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, Vol. 82回, p. 2T20p-16, 2009/09
  • Regulation of innate immune response by an autophagy-related protein, Tatsuya Saitoh,Naonobu Fujita,Tamotsu Yoshimori,Shizuo Akira, AUTOPHAGY, LANDES BIOSCIENCE, Vol. 5, No. 6, p. 909-909, 2009/08
  • Contribution of TIR domain-containing adapter inducing IFN-β-mediated IL-18 release to LPS-induced liver injury in mice, Michiko Imamura,Hiroko Tsutsui,Koubun Yasuda,Ryosuke Uchiyama,Shizue Yumikura-Futatsugi,Keiko Mitani,Shuhei Hayashi,Shizuo Akira,Shun-ichiro Taniguchi,Nico Van Rooijen,Jurg Tschopp,Tetsuya Yamamoto,Jiro Fujimoto,Kenji Nakanishi, Journal of Hepatology, Vol. 51, No. 2, p. 333-341, 2009/08
  • Toll-like Receptor 2 Mediates Apolipoprotein CIII-Induced Monocyte Activation, Akio Kawakami,Mizuko Osaka,Masanori Aikawa,Satoshi Uematsu,Shizuo Akira,Peter Libby,Kentaro Shimokado,Frank M. Sacks,Masayuki Yoshida, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 29, No. 7, p. E24-E24, 2009/07
  • オートファジーと炎症, 齊藤達哉,藤田尚信,吉森 保,審良静男, 細胞, Vol. 41, No. 7, p. 17-20, 2009/07
  • 【オートファジー メカニズムと生理機能】オートファジーと炎症, 齊藤 達哉,藤田 尚信,吉森 保,審良 静男, 細胞, (株)ニュー・サイエンス社, Vol. 41, No. 7, p. 283-286, 2009/07
  • FRONTIERS OF RESEARCH ON INNATE IMMUNITY, Kumagai Yutaro,Saitoh Tatsuya,Akira Shizuo, Japanese Journal of Allergology, 一般社団法人日本アレルギー学会, Vol. 58, No. 6, p. 638-647, 2009/06/30
  • Pathogen recognition by innate immunity and its signaling (vol 85, pg 143, 2009), Shizuo Akira, PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, JAPAN ACAD, Vol. 85, No. 6, p. 216-216, 2009/06
  • Pathogen recognition by innate immunity and its signaling (vol 85, pg 143, 2009), Shizuo Akira, PROCEEDINGS OF THE JAPAN ACADEMY SERIES A-MATHEMATICAL SCIENCES, JAPAN ACAD, Vol. 85, No. 6, p. 216-216, 2009/06
  • 多発性硬化症における誘導型プロスタグランジンE合成酵素の役割(Role of microsomal prostaglandin E synthetase-1 in multiple sclerosis), 竹内 千仙,松本 陽,神山 邦子,植松 智,審良 静男,山形 要人,竹宮 孝子, 神経化学, 日本神経化学会, Vol. 48, No. 2-3, p. 200-200, 2009/06
  • [Immunological mechanism of DNA vaccine efficacy]., Shohei Koyama,Tatsukata Kawagoe,Shizuo Akira,Ken Ishii, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 54, p. 1096-1100, 2009/06/01
  • 【感染現象 その理解の深化から疾患制御への展望】生体防御機構研究の新展開 オートファジーによる炎症反応制御, 齊藤 達哉,藤田 尚信,吉森 保,審良 静男, 蛋白質・核酸・酵素, 共立出版(株), Vol. 54, No. 8, p. 1119-1124, 2009/06
  • TLR-Independent Signaling Pathway in IFN-beta Production by Replication-Incompetent Adenovirus Vectors, Tomoko Yamaguchi,Kenji Kawabata,Ken Ishii,Fuminori Sakurai,Shizuo Akira,Hiroyuki Mizuguchi, MOLECULAR THERAPY, NATURE PUBLISHING GROUP, Vol. 17, p. S244-S244, 2009/05
  • Pathogen recognition by innate immunity and its signaling, Shizuo Akira, PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, JAPAN ACAD, Vol. 85, No. 4, p. 143-156, 2009/04
  • In Vivo Effects of Toll-like Receptor Signaling on T-cell Responses for GVHD and GVL, Bruce R. Blazar,Jeffrey S. Miller,Angela Panoskaltsis-Mortari,Brenda J. Weigel,Arthur M. Krieg,Arlene H. Sharpe,William J. Murphy,Jonathan S. Serody,Hiroaki Hemmi,Shizuo Akira,Robert B. Levy,Patricia A. Taylor, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 31, No. 4, p. 240-241, 2009/04
  • MyD88 is required for viral -induced B cell activation and intestinal IgA production, Sarah Elizabeth Blutt,Shizuo Akira,Lynn Dustin,Margaret E. Conner, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 182, 2009/04
  • Type-I interferon modulates monocyte recruitment and maturation in chronic inflammation, Pui Y. Lee,Yi Li,Yutaro Kumagai,Jason Weinstein,Dina Nacionales,Edward Butfiloski,Erinn Kellner,Shizuo Akira,Eric Sobel,Minoru Satoh,Westley Reeves, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 182, 2009/04
  • 多発性硬化症モデルにおける包括的リピドミクスとプロスタグランジンE2の機能, 木原 泰行,石井 聡,北 芳博,松下 拓也,植松 智,審良 静男,吉良 潤一,清水 孝雄, 神経免疫学, 日本神経免疫学会, Vol. 17, No. 1, p. 104-104, 2009/03
  • 6-OHDA投与マウスパーキンソン病モデルにおけるmPGES-1の役割の検討, 溝口 智子,松尾 由理,植松 智,審良 静男,佐々木 泰治, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 3, p. 206-206, 2009/03
  • MPTP誘発パーキンソン病モデルでの黒質神経脱落における膜結合型プロスタグランジンE合成酵素の関与, 鴨井 幹夫,松尾 由理,植松 智,審良 静男,佐々木 泰治, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 129年会, No. 3, p. 206-206, 2009/03
  • Functional coupling of microsomal prostaglandin E synthase-1 and cyclooxygenase-2 in stroke-reperfusion injury, Yuri Hirayama,Yuri Ikeda-Matsuo,Satoshi Uematsu,Shizuo Akira,Yasuharu Sasaki, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 109, p. 157P-157P, 2009
  • Co-induction of mPGES-1 with COX-2 deteriorates glutamate excitotoxicity in hippocampal slice cultures, Yuri Ikeda-Matsuo,Azusa Ota,Satoshi Uematsu,Shizuo Akira,Yasuharu Sasaki, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 109, p. 95P-95P, 2009
  • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, KO mice have neuroprotective effects against focal cerebral ischemia in mice, Kana Hyakkoku,Kazuhiro Tsuruma,Masamitsu Shimazawa,Hiroyuki Tanaka,Satoshi Uematsu,Shizuo Akira,Hiroichi Nagai,Hideaki Hara, JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOC, Vol. 109, p. 225P-225P, 2009
  • Innate immunity to pathogens: diversity in receptors for microbial recognition, Shizuo Akira, IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, Vol. 227, p. 5-8, 2009/01
  • TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis, Tatsukata Kawagoe,Osamu Takeuchi,Yoshitsugu Takabatake,Hiroki Kato,Yoshitaka Isaka,Tohru Tsujimura,Shizuo Akira, Nature Immunology, Vol. 10, No. 9, p. 965-972, 2009
  • オートファジー関連遺伝子Atg16L1はエンドトキシンによる炎症反応を制御している, 齊藤達哉,藤田尚信,吉森 保,審良静男, 実験医学, Vol. 27, No. 8, p. 1247-1250, 2009
  • オートファジー関連遺伝子Atg16L1によるエンドトキシン誘導性炎症反応の制御, 齊藤達哉,藤田尚信,吉森 保,審良静男, 分子消化器病,, Vol. 6, No. 1, p. 92-95, 2009
  • 【メンブレントラフィックの奔流 分子から細胞、そして個体へ】メンブレントラフィックと高次機能 メンブレントラフィックと感染・免疫 オートファジーと自然免疫応答, 齊藤 達哉,藤田 尚信,吉森 保,審良 静男, 蛋白質・核酸・酵素, 共立出版(株), Vol. 53, No. 16, p. 2279-2285, 2008/12
  • Gene-specific requirement of a nuclear protein, IκB-ζ, for promoter association of inflammatory transcription regulators, Soh Yamazaki,Susumu Matsuo,Tatsushi Muta,Masahiro Yamamoto,Shizuo Akira,Koichiro Takeshige, Journal of Biological Chemistry, Vol. 283, No. 47, p. 32404-32411, 2008/11/21
  • Molecular and cellular mechanisms of DNA vaccines, Cevayir Coban,Shohei Koyama,Fumihiko Takeshita,Shizuo Akira,Ken J. Ishii, HUMAN VACCINES, LANDES BIOSCIENCE, Vol. 4, No. 6, p. 453-457, 2008/11
  • タンパク質分解を介した新たな生理機能 オートファジー関連分子Atg16L1はエンドトキシンによるインフラマソーム活性化を制御する(Atg16L1, an autophagy protein, controls endotoxin-induced inflammasome activation), 齊藤 達哉,藤田 尚信,張 明浩,植松 智,梁 甫伎,佐藤 荘,大森 弘子,野田 健司,山本 直樹,小松 雅明,田中 啓二,河合 太郎,辻村 亨,竹内 理,吉森 保,審良 静男, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, Vol. 81回・31回, p. 4S3-7, 2008/11
  • Toll-Like 2 Receptor Mediates Apolipoprotein CIII-Induced Monocyte Activation, Akio Kawakami,Masanori Aikawa,Satoshi Uematsu,Shizuo Akira,Peter Libby,Kentaro Shimokado,Frank M. Sacks,Masayuki Yoshida, CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 118, No. 18, p. S570-S570, 2008/10
  • Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess, Werner Stenzel,Sabine Soltek,Monica Sanchez-Ruiz,Shizuo Akira,Hrvoje Miletic,Dirk Schlueter,Martina Deckert, JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, Vol. 203, No. 2, p. 271-271, 2008/10
  • Tlr-7-dependent and Fc gamma R-independent production of type I interferon in experimental murine lupus, Pui Y. Lee,Yutaro Kumagai,Yi Li,Jason Weinstein,Osamu Takeuchi,Dina Nacionales,Tole Barker,Taro Kawai,Minoru Satoh,Shizuo Akira,Westley Reeves, ARTHRITIS AND RHEUMATISM, WILEY-LISS, Vol. 58, No. 9, p. S903-S903, 2008/09
  • 血管内皮細胞mPGES-1はEP3を介してアストロサイトのCa2+依存性グルタミン酸放出を制御する(Endothelial mPGES-1 regulates Ca2+-dependent glutamate release from astrocyte via EP3), 竹宮 孝子,松村 潔,杉浦 弘子,安田 新,植松 智,審良 静男,山形 要人, 神経化学, 日本神経化学会, Vol. 47, No. 2-3, p. 224-224, 2008/08
  • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5, Hiroki Kato,Osamu Takeuchi,Eriko Mikamo-Satoh,Reiko Hirai,Tomoji Kawai,Kazufumi Matsushita,Akane Hiiragi,Terence S. Dermody,Takashi Fujita,Shizuo Akira, JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIV PRESS, Vol. 205, No. 7, p. 1601-1610, 2008/07
  • Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5, Satoshi Uematsu,Kosuke Fujimoto,Myoung Ho Jang,Bo-Gie Yang,Yun-Jae Jung,Mika Nishiyama,Shintaro Sato,Tohru Tsujimura,Masafumi Yamamoto,Yoshifumi Yokota,Hiroshi Kiyono,Masayuki Miyasaka,Ken J. Ishii,Shizuo Akira, Nature Immunology, Vol. 9, No. 7, p. 769-776, 2008/07
  • Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections, Ken J. Ishii,Shohei Koyama,Atsushi Nakagawa,Cevayir Coban,Shizuo Akira, Cell Host and Microbe, Vol. 3, No. 6, p. 352-363, 2008/06/12
  • Toll-like 2 receptor mediates apolipoprotein CIII-Induced monocyte activation, Akio Kawakami,Mizuko Osaka,Masanori Aikawa,Satoshi Uematsu,Shizuo Akira,Peter Libby,Kentaro Shimokado,Frank M. Sacks,Masayuki Yoshida, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 28, No. 6, p. E89-E89, 2008/06
  • Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells, Noriyuki Hirata,Yoshiki Yanagawa,Takashi Ebihara,Tsukasa Seya,Satoshi Uematsu,Shizuo Akira,Fumie Hayashi,Kazuya Iwabuchi,Kazunori Onoe, MOLECULAR IMMUNOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 45, No. 10, p. 2734-2742, 2008/05
  • TLR4とTLR2を介して刺激された樹状細胞における選択的かつ相乗的な抗炎症性サイトカインの産生, 平田 徳幸,柳川 芳毅,海老原 敬,瀬谷 司,植松 智,審良 静男,林 史恵,岩渕 和也,小野江 和則, 日本リンパ網内系学会会誌, (一社)日本リンパ網内系学会, Vol. 48, p. 103-103, 2008/05
  • Autophagyと免疫応答, 齊藤 達哉,吉森 保,審良 静男, 臨床免疫・アレルギー科, (有)科学評論社, Vol. 49, No. 5, p. 572-577, 2008/05
  • Hierarchical requirement for CpG Motifs in dendritic cell activation induced by DNA-containing immune-complexes, Kei Yasuda,Melissa B. Uccellini,Christophe Richez,Gregory A. Viglianti,Shizuo Akira,Ann Marshak-Rothstein,Ian R. Rifkin, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 22, 2008/04
  • Role of TLR7 and TLR9 in a murine model of SLE, M-L. Santiago-Raber,P. Borel,S. Uematsu,S. Akira,S. Izuil, SWISS MEDICAL WEEKLY, E M H SWISS MEDICAL PUBLISHERS LTD, Vol. 138, p. 15S-15S, 2008/04
  • Induction of adaptive immunity by flagellin does not require TLR5 or robust innate immune activation, Catherine Sanders,Satoshi Uematsu,Shizuo Akira,Andrew T. Gewirtz, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 22, 2008/04
  • MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Pneumonia infection following oral vaccination with attenuated Salmonella expressing PspA antigen, Sung-Moo Park,Jin-Young Yang,Satoshi Uematsu,Shizuo Akira,Roy Curtiss,Mi-Na Kweon, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 22, 2008/04
  • 自然免疫と結核, 植松 智,審良 静男, 結核, (一社)日本結核病学会, Vol. 83, No. 2, p. 101-109, 2008/02
  • 自然免疫による病原体認識機構, 植松 智,審良 静男, 皮膚の科学, 日本皮膚科学会-大阪地方会・京滋地方会, Vol. 7, No. 1, p. 1-11, 2008/02
  • 寄生体の宿主認識と宿主の寄生体認識 腸管におけるToll-like receptor 5の機能とSalmonella Typhimurium感染における役割, 植松 智,審良 静男, 日本細菌学雑誌, 日本細菌学会, Vol. 63, No. 1, p. 55-55, 2008/02
  • Molecular and cellular mechanisms of DNA vaccines, Cevayir Coban,Shohei Koyama,Fumihiko Takeshita,Shizuo Akira,Ken J. Ishii, Human Vaccines, Vol. 4, No. 6, p. 453-456, 2008
  • Innate immunity, Ken J. Ishii,Shizuo Akira, Clinical Immunology, Elsevier Ltd, p. 39-51, 2008
  • Physical and functional interactions between ZIP kinase and UbcH5., OHBAYASHI Norihiko,OKADA Katsuya,KAWAKAMI Shiho,TOGI Sumihito,SATO Noriko,IKEDA Osamu,KAMITANI Shinya,MUROMOTO Ryuta,SEKINE Yuichi,KAWAI Taro,AKIRA Shizuo,MATSUDA Tadashi, Biochem. Biophys. Res. Commun., Vol. 372, No. 4, p. 708-712, 2008
  • 【粘膜免疫からの感染と免疫応答機構 体の入口から呼吸器・消化器、生殖器、皮膚までの制御システム】 消化器官での病原体と宿主の攻防 腸管における自然免疫機構, 植松 智,審良 静男, 実験医学, (株)羊土社, Vol. 25, No. 20, p. 3190-3195, 2007/12
  • The obligate role of TAK1 in the survival of hematopoietic stem cells and progenitors in mice, Minghui Tang,Zhenbiao Xia,Shubin Zhang,Shanshan Zhang,Xudong Wei,Peter Breslin,Wei Wei,Manuel Diaz,Shizuo Akira,Jiwang Zhang, BLOOD, AMER SOC HEMATOLOGY, Vol. 110, No. 11, p. 198A-198A, 2007/11
  • TLR-dependent and independent anti-viral responses, Shizuo Akira, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, BLACKWELL PUBLISHING, Vol. 22, p. A2-A2, 2007/10
  • Contribution of TRIF to secretion of mature IL-1 beta and IL-18 via the TLR-mediated caspase-1 activation during extracellular bacterial infection in mice, Michiko Imamura,Koubun Yasuda,Jiro Fujimoto,Shizuo Akira,Hiroko Tsutsui,Kenji Nakanishi, HEPATOLOGY, JOHN WILEY & SONS INC, Vol. 46, No. 4, p. 692A-692A, 2007/10
  • 尿酸塩結晶と自然免疫とシグナル受容, 斉藤達哉,審良静男, 高尿酸血症と痛風, Vol. 15, No. 2, p. 116-119, 2007/09
  • Functional role of RIG-I family in antiviral responses, Hiroki Kato,Shizuo Akira, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT INC, Vol. 27, No. 8, p. 691-691, 2007/08
  • Distinct RIG-I and MDA5 signaling regulation by RNA viruses in innate immunity, Yueh-Ming Loo,Jamie Fornek,Nanette Crochet,Hui Zeng,Shizuo Akira,Michelle A. Gill,Terrence M. Tumpey,Adolfo Garcia-Sastre,Michael G. Katze,Michael Gale, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT INC, Vol. 27, No. 8, p. 697-697, 2007/08
  • TLR4 signaling: negative regulation by degradation, Osamu Takeuchi,Shizuo Akira, BLOOD, AMER SOC HEMATOLOGY, Vol. 110, No. 3, p. 794-794, 2007/08
  • Toll-like receptorと自然免疫, 植松 智,審良 静男, 生化学, (公社)日本生化学会, Vol. 79, No. 8, p. 769-776, 2007/08
  • Regulation of endotoxin tolerance by myeloid differentiation factor 88-independent signaling and its downstream cytokine, interferon beta, Subhra K. Biswas,Pradeep Bist,Manprit Dhillon,Tasneem Kajiji,Carlos Del Fresno,Masahiro Yamamoto,Eduardo Lopez-Collazo,Shizuo Akira,Vinay Tergaonkar, CYTOKINE, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 3-3, 2007/07
  • Effects of combined TLR stimulation on interleukin-27 mRNA expression in human monocyte-derived dendritic cells, Sinead M. Migpin,Eva Palsson-McDermott,Aisling Dunne,Caroline Jefferies,Emmanuel Pinteaux,Kathy Banahan,Caroline Murphy,Paul Moynagh,Masahiro Yamamoto,Shizuo Akira,Nancy Rothwell,Douglas Golenbock,Katherine A. Fitzgerald,Luke A. J. O'Neill, CYTOKINE, ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Vol. 39, No. 1, p. 27-28, 2007/07
  • Toll or toll-free adjuvant path toward the optimal vaccine development, Ken J. Ishii,Shizuo Akira, Journal of Clinical Immunology, Vol. 27, No. 4, p. 363-371, 2007/07
  • PATHOGEN RECOGNITION BY INNATE IMMUNITY, Takeuchi Osamu,Akira Shizuo, Japanese Journal of Allergology, The Japanese Society of Allergology, Vol. 56, No. 6, p. 558-562, 2007/06/30
  • Chronic TLR4 and MyD88 activation causes hepatic insulin resistance by impairing PI3K inhibition of NF kappa B, Carl F. Raetzsch,Natasha L. Brooks,Kelli S. Moore,Thomas Marshall,Simon Klebanov,Leah J. Watson,Chad M. Trent,Lawrence L. Kupper,Shizuo Akira,James E. Bear,Jonathan S. Serody,James A. Swenberg,Terry P. Combs, DIABETES, AMER DIABETES ASSOC, Vol. 56, p. A348-A348, 2007/06
  • TLR5 is not critical for humoral immune responses to purified flagellin or co-administered antigens, Catherine J. Sanders,Shizuo Akira,Andrew T. Gewirtz, JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 178, 2007/04
  • TLR5-Deficient mice fail to control their commensal microflora and develop spontaneous colitis, Matam Vijay-kumar,Catherine Sanders,Shizuo Akira,Andrew S. Neish,Shanthi V. Sitaraman,Ifor R. Williams,Andrew Gewirtz, GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 132, No. 4, p. A103-A103, 2007/04
  • TLR5 protects the intestine from salmonella but promotes the systemic disease caused by this pathogen, Matam Vijay-Kumar,Catherine Sanders,Shizuo Akira,Shandin V. Sitaraman,Andrew S. Neish,Andrew Gewirtz, GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 132, No. 4, p. A49-A49, 2007/04
  • Toll-like receptor-4 initiates the innate immune response of the kidney to renal ischemia-reperfusion injury, Wilco Pulskens,Gwen Teske,Shizuo Akira,Tom van der Poll,Sandrine Florquin,Jaklien Leemans, INFLAMMATION RESEARCH, BIRKHAUSER VERLAG AG, Vol. 56, p. S116-S117, 2007/03
  • 膜結合型プロスタグランジンE合成酵素のカラゲニン誘導マウス胸膜炎への関与の解析, 種本 明生,亀井 大輔,中谷 良人,植松 智,審良 静男,原 俊太郎,工藤 一郎, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 2, p. 10-10, 2007/03
  • 中大脳動脈閉塞-再灌流障害における膜結合型プロスタグランジンE2合成酵素の役割, 松尾 由理,太田 梓,深田 哲也,植松 智,審良 静男,佐々木 泰治, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 2, p. 19-19, 2007/03
  • 膜結合型プロスタグランジンE合成酵素(mPGES-1)のがん悪性化への関与の解析, 佐々木 由香,亀井 大輔,黒澤 まみ,中谷 良人,植松 智,審良 静男,石川 由起雄,石井 壽晴,村上 誠,原 俊太郎,工藤 一郎, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 127年会, No. 2, p. 76-76, 2007/03
  • 【自然免疫】 Toll-like receptorとRNAヘリカーゼ, 植松 智,審良 静男, 臨床とウイルス, 日本臨床ウイルス学会, Vol. 35, No. 1, p. 40-50, 2007/03
  • 【新感染症学 新時代の基礎・臨床研究】 感染症学総論 感染症発症のメカニズム 病原体認識とToll様受容体, 高橋 健,河合 太郎,審良 静男, 日本臨床, (株)日本臨床社, Vol. 65, No. 増刊2 新感染症学(上), p. 53-57, 2007/02
  • Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2, Chul-Su Yang,Ji-Sook Lee,Chang-Hwa Song,Gang Min Hur,Sung Joong Lee,Sakae Tanaka,Shizuo Akira,Tae-Hyun Paik,Eun-Kyeong Jo, Cellular Microbiology, Vol. 9, No. 2, p. 382-396, 2007/02
  • A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity, Donghoon Kim,Myung Ah Kim,Ik-Hyun Cho,Soojin Lee,Eun-Kyeong Jo,Shizuo Akira,Heung Sik Na,Seog Bae Oh,Sung Joong Lee, NEURON GLIA BIOLOGY, CAMBRIDGE UNIV PRESS, Vol. 2, p. S164-S164, 2007
  • Toll-like receptor-dependent and -independent viral recognition in innate immunity, Shizuo Akira, ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN, Vol. 57, No. 1, p. 57-57, 2007
  • Microsomal prostaglandin e synthase-1 deficiency increases dust mite antigen-induced airway inflammation, S. N. Nallamshetty,S. Uematsu,S. Akira,J. A. Boyce, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 119, No. 1, p. S131-S131, 2007/01
  • Pathological role of Toll-like receptor signaling in cerebral malaria, Cevayir Coban,Satoshi Uematsu,Nobuko Arisue,Shintaro Sato,Masahiro Yamamoto,Taro Kawai,Osamu Takeuchi,Hajime Hisaeda,Toshihiro Horii,Shizuo Akira, International Immunology, Vol. 19, No. 1, p. 67-79, 2007/01
  • 自然免疫--システム生物学的アプローチの果たしうる役割 (第1土曜特集 システム生物医学) -- (疾患のシステム生物医学), 熊谷 雄太郎,竹内 理,審良 静男, 医学のあゆみ, 医歯薬出版, Vol. 219, No. 9, p. 707-713, 2006/12/02
  • 【免疫研究最前線 2007】 自然免疫応答の制御 自然免疫によるウイルス認識, 植松 智,審良 静男, 実験医学, (株)羊土社, Vol. 24, No. 20, p. 3130-3137, 2006/12
  • In vivo CpG administration accelerates graft-versus-host disease (GVHD) lethality by toll-like receptor 9 (TLR9) ligation of host antigen-presenting cells (APCs) and promotes allogeneic bone marrow (BM) rejection by TLR9 ligation of donor APCs., Bruce R. Blazar,Angela Panoskaltsis-Mortari,Arthur M. Krieg,Hiroaki Hemmi,Shizuo Akira,Jonathan Serody,William J. Murphy,Patricia A. Taylor, BLOOD, AMER SOC HEMATOLOGY, Vol. 108, No. 11, p. 136A-136A, 2006/11
  • 樹状細胞サブセットと機能 Toll-like receptor 7/9刺激樹状細胞によるI型インターフェロン産生誘導におけるIκBキナーゼ-αの機能, 星野 克明,杉山 孝弘,松本 満,田中 貴志,審良 静男,改正 恒康, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 36, p. 212-212, 2006/11
  • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction, Kojiro Sato,Ayako Suematsu,Kazuo Okamoto,Akira Yamaguchi,Yasuyuki Morishita,Yuho Kadono,Sakae Tanaka,Tatsuhiko Kodama,Shizuo Akira,Yoichiro Iwakura,Daniel J. Cua,Hiroshi Takayanagi, Journal of Experimental Medicine, Vol. 203, No. 12, p. 2673-2682, 2006/11
  • 'Toll' gates for future immunotherapy, Ken J. Ishii,Satoshi Uematsu,Shizuo Akira, Current Pharmaceutical Design, Vol. 12, No. 32, p. 4135-4142, 2006/11
  • Innate immune recognition of, and regulation by, DNA, Ken J. Ishii,Shizuo Akira, Trends in Immunology, Vol. 27, No. 11, p. 525-532, 2006/11
  • Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response, Sara W. Montminy,Naseema Khan,Sara McGrath,Mitchell J. Walkowicz,Fiona Sharp,Joseph E. Conlon,Koichi Fukase,Shoichi Kusumoto,Charles Sweet,Kensuke Miyake,Shizuo Akira,Robert J. Cotter,Jon D. Goguen,Egil Lien, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 7, No. 10, p. 1066-1073, 2006/10
  • Viral recognition by innate immunity, Shizuo Akira, JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE BV, Vol. 178, p. 9-9, 2006/09
  • Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier, Naohiko Shimada,Ken J. Ishii,Yoichi Takeda,Cevayir Coban,Yuichi Torii,Seiji Shinkai,Shizuo Akira,Kazuo Sakurai, BIOCONJUGATE CHEMISTRY, AMER CHEMICAL SOC, Vol. 17, No. 5, p. 1136-1140, 2006/09
  • Cell type specific involvement of RIG-I in antiviral responses, Hiroki Kato,Osamu Takeuchi,Shizuo Akira, Nippon rinsho. Japanese journal of clinical medicine, Vol. 64, No. 7, p. 1244-1247, 2006/07
  • 脳虚血障害における膜結合型プロスタグランジンE2合成酵素の役割の解析, 松尾 由理,太田 梓,深田 哲也,植松 智,審良 静男,佐々木 泰治, Inflammation and Regeneration, 日本炎症・再生医学会, Vol. 26, No. 4, p. 326-326, 2006/07
  • がんの骨転移と骨破壊における膜型プロスタグランジンE合成酵素-1(mPGES-1)の関与 mPGES-1ノックアウトマウスを用いた解析, 瀧田 守親,稲田 全規,植松 智,審良 静男,宮浦 千里, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 24回, p. 174-174, 2006/07
  • 【インターフェロン治療学 最新の基礎・臨床研究】 基礎研究の進歩 自然免疫とI型IFN I型IFN誘導におけるシグナル伝達分子IPS-1の役割, 河合 太郎,審良 静男, 日本臨床, (株)日本臨床社, Vol. 64, No. 7, p. 1231-1235, 2006/07
  • Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans., Kiwamu Nakamura,Kazuya Miyagi,Yoshinobu Koguchi,Yuki Kinjo,Kaori Uezu,Takeshi Kinjo,Morikazu Akamine,Jiro Fujita,Ikuo Kawamura,Masao Mitsuyama,Yoshiyuki Adachi,Naohito Ohno,Kiyoshi Takeda,Shizuo Akira,Akiko Miyazato,Mitsuo Kaku,Kazuyoshi Kawakami, FEMS immunology and medical microbiology, Vol. 47, No. 1, p. 148-54, 2006/06
  • 自然免疫におけるウイルス感染認識機構, 植松 智,審良 静男, ウイルス, 日本ウイルス学会, Vol. 56, No. 1, p. 1-8, 2006/06
  • 医学と医療の最前線 自然免疫とToll-likeレセプター, 植松 智,審良 静男, 日本内科学会雑誌, (一社)日本内科学会, Vol. 95, No. 6, p. 1115-1121, 2006/06
  • TLR signaling, T. Kawai,S. Akira, Cell Death and Differentiation, Vol. 13, No. 5, p. 816-825, 2006/05
  • Toll-like receptor function and signaling, Tsuneyasu Kaisho,Shizuo Akira, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY-ELSEVIER, Vol. 117, No. 5, p. 979-987, 2006/05
  • 細菌由来リポペプチドはtoll-like receptor2を介してマウスケラチノサイトにβ-defensin3を誘導する, 澄川 靖之,浅田 秀夫,星野 克明,小豆澤 宏明,片山 一朗,審良 静男,板見 智, 日本研究皮膚科学会年次学術大会・総会プログラム, (一社)日本研究皮膚科学会, Vol. 31回, p. 99-99, 2006/04
  • Toll-like receptorsによる病原体の認識, 植松 智,審良 静男, 小児感染免疫, 日本小児感染症学会, Vol. 18, No. 1, p. 33-40, 2006/04
  • Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48)), Ken J. Ishii,Cevayir Coban,Hiroki Kato,Ken Takahashi,Yuichi Torii,Fumihiko Takeshita,Holger Ludwig,Gerd Sutter,Koichi Suzuki,Hiroaki Hemmi,Shintaro Sato,Masahiro Yamamoto,Satoshi Uematsu,Taro Kawai,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 4, 2006/04
  • Modifying toll-like receptor 9 signaling for therapeutic use, Rabindra N. Bhattacharjee,Shizuo Akira, Mini-Reviews in Medicinal Chemistry, Vol. 6, No. 3, p. 287-291, 2006/03
  • インターフェロン発現にかかわる新しい分子:IPS-1, 河合 太郎,審良 静男, 感染・炎症・免疫, 鳥居薬品(株), Vol. 36, No. 1, p. 87-89, 2006/03
  • TLR-Dependent Induction of IFN-b Mediates Host Defense against Trypanosoma cruzi., Koga, R,Hamano, S,Kuwata, H,Atarashi, K,Ogawa, M,Hisaeda, H,Yamamoto, M,Akira, S,Himeno, K,Matsumoto, M,Takeda, K, J. Immunol., Vol. 177, No. 10, p. 7059-7066, 2006
  • Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease (vol 11, pg 138, 2005), KS Lang,M Recher,T Junt,AA Navarini,NL Harris,S Freigang,B Odermatt,C Conrad,LM Ittner,S Bauer,SA Luther,S Uematsu,S Akira,H Hengartner,RM Zinkernagel, NATURE MEDICINE, NATURE PUBLISHING GROUP, Vol. 11, No. 11, p. 1256-1256, 2005/11
  • Flt3L誘導骨髄樹状細胞におけるToll-like receptor 3を介するシグナル伝達機構の解析, 星野 克明,杉山 孝弘,田中 貴志,審良 静男,改正 恒康, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 35, p. 47-47, 2005/11
  • IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす, 植松 智,佐藤 慎太郎,山本 雅裕,加藤 博己,石井 健,河合 太郎,竹内 理,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 35, p. 47-47, 2005/11
  • マウスstrawberry notch homologue遺伝子の解析, 坂尾 宣充,植松 智,竹内 理,安居 輝人,竹田 潔,改正 恒康,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 35, p. 60-60, 2005/11
  • 【解明が進むウイルス・細菌感染と免疫応答 分子メカニズムから新たな治療戦略まで】 病原体感染に対する免疫応答メカニズム Toll-like receptorによる生体防御, 植松 智,審良 静男, 実験医学, (株)羊土社, Vol. 23, No. 17, p. 2660-2665, 2005/10
  • Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway (vol 6, pg 844, 2005), WJ de Jonge,EP van der Zanden,F O The,MF Bijlsma,DJ van Westerloo,RJ Bennink,HR Berthoud,S Uematsu,S Akira,RM van den Wijngaard,GE Boeckxstaens, NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, Vol. 6, No. 9, p. 954-954, 2005/09
  • PGE2はカイニン酸によってもたらされる海馬神経細胞消失を調節している(PGE2 modulates the hippocampal neuron loss induced by kainic acid), 竹宮 孝子,松村 潔,前原 通代,植松 智,鈴木 香子,杉浦 弘子,審良 静男,山形 要人, 神経化学, 日本神経化学会, Vol. 44, No. 2-3, p. 181-181, 2005/08
  • 大脳虚血において誘導されるミクロソームプロスタグランジンE2合成酵素1の神経毒性機能(Neurotoxic function of induced microsomal prostaglandin E2 synthase-1 in cerebral ischemia), 太田 梓,松尾 由理,植松 智,審良 静男,佐々木 泰治, 神経化学, 日本神経化学会, Vol. 44, No. 2-3, p. 185-185, 2005/08
  • TLR ignores methylated RNA?, Ken J. Ishii,Shizuo Akira, Immunity, Vol. 23, No. 2, p. 111-113, 2005/08
  • Erratum: CpG RNA: Identification of novel single-stranded RNA that stimulates human CD14<sup>+</sup>CD11c<sup>+</sup>monocytes (Journal of Immunology (2005) 174 (2273-2279)), T. Sugiyama,M. Gursel,F. Takeshita,C. Coban,J. Conover,T. Kaisho,S. Akira,D. M. Klinman,K. J. Ishii, Journal of Immunology, Vol. 175, 2005/08/01
  • Priming effect of lipopolysaccharide on acetyl-coenzyme A: Lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent, Hideo Shindou,Satoshi Ishii,Masahiro Yamamoto,Kiyoshi Takeda,Shizuo Akira,Takao Shimizu, Journal of Immunology, American Association of Immunologists, Vol. 175, No. 2, p. 1177-1183, 2005/07/15
  • 膜型プロスタグランジンE2合成酵素-1(mPGES-1)の骨折治癒および変形性関節症への関与, 山川 聖史,亀倉 暁,村上 誠,工藤 一郎,植松 智,審良 静男,中村 耕三,川口 浩, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 23回, p. 169-169, 2005/06
  • 【わかりやすい免疫疾患】 免疫の基礎 感染と免疫 感染に対する生体防御機構, 植松 智,審良 静男, 日本医師会雑誌, 日本医師会, Vol. 134, No. 特別1, p. S69-S72, 2005/06
  • 膜型プロスタグランジンE2合成酵素-1(mPGES-1)は炎症性骨吸収治療のための重要な標的分子である, 山川 聖史,三枝 正朋,亀井 大輔,竹越 唯衣,植松 智,審良 静男,村上 誠,工藤 一郎,中村 耕三,川口 浩, Osteoporosis Japan, ライフサイエンス出版(株), Vol. 13, No. 2, p. 378-382, 2005/05
  • 膜結合型プロスタグランジンE合成酵素(mPGES-1)欠損マウスにおける炎症性肉芽形成の抑制, 竹越 唯衣,亀井 大輔,大石 幸子,植松 智,審良 静男,平澤 典保,大内 和雄,石川 由紀雄,石井 壽晴,村上 誠,工藤 一郎, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 125年会, No. 3, p. 28-28, 2005/03
  • CpG RNA: Identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes, Takahiro Sugiyama,Mayda Gursel,Fumihiko Takeshita,Cevayir Coban,Jacqueline Conover,Tsuneyasu Kaisho,Shizuo Akira,Dennis M. Klinman,Ken J. Ishii, Journal of Immunology, American Association of Immunologists, Vol. 174, No. 4, p. 2273-2279, 2005/02/15
  • Toll-like receptor downstream signaling, Taro Kawai,Shizuo Akira, Arthritis Research and Therapy, Vol. 7, No. 1, p. 12-19, 2005/02
  • 医学と医療の最前線 Toll-like receptorによる生体防御機構, 植松 智,審良 静男, 日本内科学会雑誌, (一社)日本内科学会, Vol. 94, No. 2, p. 355-361, 2005/02
  • Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin, Cevayir Coban,Ken J. Ishii,Taro Kawai,Hiroaki Hemmi,Shintaro Sato,Satoshi Uematsu,Masahiro Yamamoto,Osamu Takeuchi,Sawako Itagaki,Nirbhay Kumar,Toshihiro Horii,Shizuo Akira, Journal of Experimental Medicine, Vol. 201, No. 1, p. 19-25, 2005/01/03
  • Toll-like receptors in innate immunity, Kiyoshi Takeda,Shizuo Akira, International Immunology, Vol. 17, No. 1, p. 1-14, 2005/01
  • TLRファミリーとウイルス感染, 植松 智,審良 静男, ウイルス, 日本ウイルス学会, Vol. 54, No. 2, p. 145-151, 2004/12
  • Therapeutic targeting of Toll-like receptors, Satoshi Uematsu,Ken J. Ishii,Shizuo Akira, Drug Discovery Today: Therapeutic Strategies, Vol. 1, No. 3, p. 299-304, 2004/12
  • 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違, 改正 恒康,邊見 弘明,山本 雅裕,竹内 理,星野 克明,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 200-200, 2004/11
  • マウスケラチノサイトにおけるtoll-like receptor 2を介したβ-defensin 3の誘導, 澄川 靖之,浅田 秀夫,板見 智,小豆澤 宏明,星野 克明,審良 静男,片山 一朗, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 287-287, 2004/11
  • Toll様受容体を介したI型IFN産生誘導のメカニズム, 河合 太郎,佐藤 慎太郎,石井 健,Coban Cevayir,辺見 弘明,山本 雅裕,植松 智,竹内 理,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 51-51, 2004/11
  • Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構, 植松 智,佐藤 慎太郎,山本 雅裕,加藤 博己,石井 健,河合 太郎,竹内 理,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 52-52, 2004/11
  • RIG-I欠損マウスの作成および解析, 加藤 博己,佐藤 慎太郎,山本 雅裕,松井 孝介,植松 智,竹田 潔,竹内 理,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 62-62, 2004/11
  • 免疫セマフォリン分子Sema4AのTh1/Th2制御における役割, 識名 崇,熊ノ郷 淳,鈴木 一博,植松 智,筒井 ひろ子,審良 静男,竹田 潔,菊谷 仁, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 34, p. 232-232, 2004/11
  • Roles of Toll-like receptor in host defense and the mechanism of its signal transduction, Osamu Takeuchi,Shizuo Akira, Nippon saikingaku zasshi. Japanese journal of bacteriology, JAPANESE SOCIETY FOR BACTERIOLOGY, Vol. 59, No. 4, p. 523-529, 2004/11
  • 膜型プロスタグランジンE2合成酵素-1(mPGES-1)は炎症性骨吸収治療のための重要な標的分子である, 山川 聖史,三枝 正朋,亀井 大輔,竹越 唯衣,植松 智,審良 静男,村上 誠,工藤 一郎,中村 耕三,川口 浩, Osteoporosis Japan, ライフサイエンス出版(株), Vol. 12, No. Suppl.1, p. 151-151, 2004/10
  • 膜結合型プロスタグランジンE合成酵素欠損マウスにおける炎症性肉芽形成の抑制, 竹越唯衣,亀井大輔,大石幸子,植松智,審良静男,平沢典保,大内和雄,石川由紀雄,石井寿晴, 生体機能と創薬シンポジウム, Vol. 2004, p. 145-146, 2004/09/01
  • 膜結合型プロスタグランジンE合成酵素(mPGES‐1)と腫よう形成, 亀井大輔,竹越唯衣,中谷良人,植松智,審良静男,石川由起雄,石井寿晴,馬嶋正隆,大石幸子, 生体機能と創薬シンポジウム, Vol. 2004, p. 142-144, 2004/09/01
  • 膜型プロスタグランジンE2合成酵素-1(mPGES-1)の炎症性骨破壊への関与 mPGES-1遺伝子欠損マウスの解析, 山川 聖史,亀井 大輔,竹越 唯衣,植松 智,審良 静男,村上 誠,工藤 一郎,中村 耕三,川口 浩, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 22回, p. 110-110, 2004/08
  • 炎症性骨吸収における膜型プロスタグランジンE合成酵素(mPGES)の関与:mPGESノックアウトマウスを用いた解析, 松本 千穂,宮浦 千里,植松 智,審良 静男, 日本骨代謝学会学術集会プログラム抄録集, (一社)日本骨代謝学会, Vol. 22回, p. 160-160, 2004/08
  • 膜結合型プロスタグランジンE合成酵素(mPGES-1)欠損マウスにおける炎症性肉芽形成の抑制, 竹越 唯衣,亀井 大輔,大石 幸子,植松 智,審良 静男,平澤 典保,大内 和雄,石川 由紀雄,石井 壽晴,村上 誠,工藤 一郎, 炎症・再生, 日本炎症・再生医学会, Vol. 24, No. 4, p. 455-455, 2004/07
  • 膜結合型PGE2合成酵素(mPGES-1)と腫瘍形成, 亀井 大輔,竹越 唯衣,中谷 良人,植松 智,審良 静男,石川 由起雄,石井 壽晴,馬嶋 正隆,大石 幸子,村上 誠,工藤 一郎, 脂質生化学研究, 日本脂質生化学会, Vol. 46, p. 36-38, 2004/05
  • Microbial recognition by Toll-like receptors, Kiyoshi Takeda,Shizuo Akira, Journal of Dermatological Science, Vol. 34, No. 2, p. 73-82, 2004/04
  • マウスケラチノサイトにおけるtoll-like receptor2を介したβdefensin3の誘導, 澄川 靖之,浅田 秀夫,星野 克明,審良 静男,板見 智, 日本研究皮膚科学会年次学術大会・総会プログラム, (一社)日本研究皮膚科学会, Vol. 29回, p. 111-111, 2004/04
  • Toll-like receptor 9 is required for IL-12 induction in response to bacterial stimulation, LYC Huang,KJ Ishii,A Bafica,S Akira,A Sher,J Aliberti,B Golding, FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, Vol. 18, No. 5, p. A1157-A1157, 2004/03
  • 膜結合型プロスタグランジンE合成酵素(mPGES-1)欠損マウスにおける炎症性疼痛反応及び肉芽形成の抑制, 竹越 唯衣,亀井 大輔,三上 麻弥,中谷 良人,大石 幸子,植松 智,審良 静男,平澤 典保,大内 和雄,村上 誠,工藤 一郎, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 124年会, No. 3, p. 87-87, 2004/03
  • Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-κB activation, Takeshi Into,Kazuto Kiura,Motoaki Yasuda,Hideo Kataoka,Nobuo Inoue,Akira Hasebe,Kiyoshi Takeda,Shizuo Akira,Ken-Ichiro Shibata, Cellular Microbiology, Vol. 6, No. 2, p. 187-199, 2004/02
  • 【自然免疫と疾患】 Toll-like receptorsと疾患, 植松 智,審良 静男, 炎症と免疫, (株)先端医学社, Vol. 12, No. 2, p. 171-177, 2004/02
  • Pleiotropic function of Toll-like receptors, Tsuneyasu Kaisho,Shizuo Akira, Microbes and Infection, Elsevier Masson SAS, Vol. 6, No. 15, p. 1388-1394, 2004
  • TLR signaling pathways, Kiyoshi Takeda,Shizuo Akira, Seminars in Immunology, Academic Press, Vol. 16, No. 1, p. 3-9, 2004
  • 【疾患モデル動物 病因解析での役割と限界】 生体防御機構 Toll様受容体ノックアウトマウスの解析, 植松 智,審良 静男, 医学のあゆみ, 医歯薬出版(株), Vol. 別冊, No. 疾患モデル動物-病因解析での役割と限界, p. 76-79, 2004/01
  • Toll-like receptors and sepsis, Ken J. Ishii,Shizuo Akira, Current Infectious Disease Reports, Current Medicine Group LLC 1, Vol. 6, No. 5, p. 361-366, 2004
  • Regulation of dendritic cell function through toll-like receptors, Tsuneyasu Kaisho,Shizuo Akira, Current Molecular Medicine, Vol. 3, No. 8, p. 759-771, 2003/12
  • Microsomal PGE Synthase 1は感染・炎症時の脳内PGE2産生と発熱に必須である 遺伝子欠損マウスを用いた研究, 松村 潔,井上 渉,水島 由美子,細川 浩,植松 智,審良 静男,小林 茂夫, 炎症・再生, 日本炎症・再生医学会, Vol. 23, No. 6, p. 477-477, 2003/11
  • TRIFはTLRのMyD88非依存的経路を担うアダプター分子である, 山本 雅裕,佐藤 慎太郎,辺見 弘明,改正 恒康,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 33, p. 122-122, 2003/11
  • TBK1/NAK/T2KはLPSによるIFN-inducible geneの発現に関与する, 邊見 弘明,佐藤 慎太郎,山本 雅裕,改正 恒康,河合 太郎,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 33, p. 123-123, 2003/11
  • 【消化器疾患と免疫】 基礎 消化器疾患と自然免疫機構, 植松 智,竹田 潔,審良 静男, 現代医療, (株)現代医療社, Vol. 35, No. 11, p. 2533-2540, 2003/11
  • Toll-like receptor signaling, Shizuo Akira, Journal of Biological Chemistry, Vol. 278, No. 40, p. 38105-38108, 2003/10/03
  • TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection, Hye Seong Mun,Fumie Aosai,Kazumi Norose,Mei Chen,Lian Xun Piao,Osamu Takeuchi,Shizuo Akira,Hiroshi Ishikura,Akihiko Yano, International Immunology, Vol. 15, No. 9, p. 1081-1087, 2003/09/01
  • Regulation of dendritic cell function through toll-like receptors, Tsuneyasu Kaisho,Shizuo Akira, Current Molecular Medicine, Vol. 3, No. 4, p. 373-385, 2003/06
  • Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways, Kaoru Hazeki,Naoyo Masuda,Kenji Funami,Naoe Sukenobu,Misako Matsumoto,Shizuo Akira,Kiyoshi Takeda,Tsukasa Seya,Osamu Hazeki, European Journal of Immunology, Vol. 33, No. 3, p. 740-747, 2003/03/01
  • Toll receptors and pathogen resistance, Kiyoshi Takeda,Shizuo Akira, Cellular Microbiology, Vol. 5, No. 3, p. 143-153, 2003/03/01
  • 膜結合型プロスタグランジンE2合成酵素の生体内機能の解析, 三上 麻弥,亀井 大輔,中谷 良人,植松 智,審良 静男,大石 幸子,村上 誠,工藤 一郎, 日本薬学会年会要旨集, (公社)日本薬学会, Vol. 123年会, No. 3, p. 77-77, 2003/03
  • 疾患モデル動物 病因解析での役割と限界 生体防御機構 Toll様受容体ノックアウトマウスの解析, 植松 智,審良 静男, 医学のあゆみ, 医歯薬出版(株), Vol. 204, No. 10, p. 758-761, 2003/03
  • Mammalian Toll-like receptors, Shizuo Akira, Current Opinion in Immunology, Elsevier Ltd, Vol. 15, No. 1, p. 5-11, 2003
  • Toll-like receptors, Kiyoshi Takeda,Tsuneyasu Kaisho,Shizuo Akira, Annual Review of Immunology, Vol. 21, p. 335-376, 2003
  • 膜結合型PGE2合成酵素の発現様式とノックアウトマウスの解析, 植松 智,松本 真琴,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 32, p. 37-37, 2002/10
  • TLR4刺激MyD88欠損樹状細胞のTh2細胞分化支持能の解析, 改正 恒康,星野 克明,竹内 理,岩部 富夫,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 32, p. 55-55, 2002/10
  • 抗マウスTLR9モノクローナル抗体の樹立, 楠本 豊,緒方 明貴,菊地 たかね,古田 隆久,赤司 祥子,長井 良憲,今野 和典,星野 克明,改正 恒康,審良 静男,木本 雅夫,三宅 健介, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 32, p. 125-125, 2002/10
  • TIRAP/MalはTLR4シグナルだけでなく,TLR2シグナルにも関わっている, 山本 雅裕,佐藤 慎太郎,辺見 弘明,山条 秀樹,植松 智,改正 恒康,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 32, p. 38-38, 2002/10
  • 【粘膜免疫からみた炎症性腸疾患】 Toll-like receptorと炎症性腸疾患, 植松 智,審良 静男, Molecular Medicine, (株)中山書店, Vol. 39, No. 9, p. 1030-1035, 2002/08
  • Essential role of MD-2 in LPS responsiveness and TLR4 distribution., Yoshinori Nagai,Sachiko Akashi,Masakazu Nagafuku,Masato Ogata,Yoichiro Iwakura,Shizuo Akira,Toshio Kitamura,Atsushi Kosugi,Masao Kimoto,Kensuke Miyake, Nature immunology, Vol. 3, No. 7, p. 667-72, 2002/07
  • ケラチノサイトにおけるToll-like receptorの発現と機能の解析, 澄川 靖之,浅田 秀夫,板見 智,吉川 邦彦,星野 克明,審良 静男, 日本皮膚科学会雑誌, (公社)日本皮膚科学会, Vol. 112, No. 5, p. 642-642, 2002/05
  • Toll-like receptors as adjuvant receptors, Tsuneyasu Kaisho,Shizuo Akira, Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1589, No. 1, p. 1-13, 2002/02/13
  • Genetic approaches to the study of Toll-like receptor function, Osamu Takeuchi,Shizuo Akira, Microbes and Infection, Vol. 4, No. 9, p. 887-895, 2002
  • Recognition of lipopeptides by Toll-like receptors, Kiyoshi Takeda,Osamu Takeuchi,Shizuo Akira, Journal of Endotoxin Research, Vol. 8, No. 6, p. 459-463, 2002
  • 【感染するメカニズム,防御するメカニズム】自然免疫系における病原細菌認識機構, 星野 克明,審良 静男, 細胞工学, (株)学研メディカル秀潤社, Vol. 21, No. 2, p. 177-181, 2002/01
  • マクロファージにおけるIL-10の標的遺伝子の同定と機能解析, 坂尾 宣充,竹田 潔,植松 智,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 31, p. 238-238, 2001/12
  • 各種DNAによる細胞活性化におけるTLR9の役割の検討, 邊見 弘明,改正 恒康,竹内 理,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 31, p. 231-231, 2001/12
  • マウス樹状細胞におけるToll-like receptorを介した遺伝子発現機構の解析, 星野 克明,岩部 富夫,竹内 理,改正 恒康,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 31, p. 231-231, 2001/12
  • LPS刺激MyD88欠損樹状細胞はTH2細胞分化支持能を有する, 改正 恒康,星野 克明,竹内 理,岩部 富夫,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 31, p. 257-257, 2001/12
  • 自然免疫系活性化によるListeria monocytogenesの排除機構, 石 亦宏,筒井 ひろ子,辻 典子,中埜 広樹,安達 圭志,竹内 理,星野 克明,審良 静男,岡村 春樹,藤元 治朗, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 31, p. 125-125, 2001/12
  • 蛋白質リン酸化・脱リン酸化による高次生命機能制御 Toll-like receptorを介するシグナル伝達経路の解析, 星野 克明,河合 太郎,審良 静男, 生化学, (公社)日本生化学会, Vol. 73, No. 8, p. 624-624, 2001/08
  • 【自然免疫(innate immunity)における細菌の認識機構 CD14とTLRを中心に】MammalianのTLR, 星野 克明,審良 静男, 炎症と免疫, (株)先端医学社, Vol. 9, No. 5, p. 550-557, 2001/08
  • TLR5はバクテリアのべん毛を識別し生体防御反応を誘起する, 星野 克明,審良 静男, 細胞工学, (株)学研メディカル秀潤社, Vol. 20, No. 8, p. 1070-1071, 2001/07
  • Regulation of innate immune responses by toll-like receptors, Kiyoshi Takeda,Shizuo Akira, Japanese Journal of Infectious Diseases, Vol. 54, No. 6, p. 209-219, 2001
  • Multi-functional roles of stat3 revealed by conditional gene targeting, Kiyoshi Takeda,Shizuo Akira, Archivum Immunologiae et Therapiae Experimentalis, Vol. 49, No. 4, p. 279-283, 2001
  • Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice, Tsuneyasu Kaisho,Shizuo Akira, Trends in Immunology, Vol. 22, No. 2, p. 78-83, 2001
  • Toll-like receptors: Critical proteins linking innate and acquired immunity, Shizuo Akira,Kiyoshi Takeda,Tsuneyasu Kaisho, Nature Immunology, Vol. 2, No. 8, p. 675-680, 2001
  • Roles of Toll-like receptors in innate immune responses, K. Takeda,S. Akira, Genes to Cells, Vol. 6, No. 9, p. 733-742, 2001
  • Toll-like receptors; their physiological role and signal transduction system, Osamu Takeuchi,Shizuo Akira, International Immunopharmacology, Vol. 1, No. 4, p. 625-635, 2001
  • リガンド非依存性CD40シグナルはLPS応答に必要である, 石田 勲,安居 輝人,七條 優子,坂尾 宣充,内田 純二,審良 静男,菊谷 仁, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 30, p. 72-72, 2000/11
  • λ-カラゲナンにより誘導される炎症反応はToll like receptor 4(TLR4)を介する, 星野 克明,辻 亮平,Nowak Bernadeta,竹田 潔,改正 恒康,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 30, p. 70-70, 2000/11
  • バクテリア由来非メチル化DNAによる免疫応答に必須なToll-like receptorの同定, 邊見 弘明,竹内 理,河合 太郎,改正 恒康,佐藤 慎太郎,山条 秀樹,星野 克明,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 30, p. 71-71, 2000/11
  • MyD88欠損樹状細胞はエンドトキシン刺激により機能的に成熟する, 改正 恒康,竹内 理,河合 太郎,星野 克明,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 30, p. 128-128, 2000/11
  • MyD88を介さない新たなLPSシグナル伝達機構, 佐藤 慎太郎,河合 太郎,星野 克明,竹内 理,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 30, p. 226-226, 2000/11
  • マクロファージにおけるIL-10の標的遺伝子の同定, 坂尾 宣充,竹田 潔,松本 真琴,横山 清司,植松 智,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 30, p. 76-76, 2000/11
  • STAT family of transcription factors in cytokine-mediated biological responses, Kiyoshi Takeda,Shizuo Akira, Cytokine and Growth Factor Reviews, Vol. 11, No. 3, p. 199-207, 2000/09/01
  • サイトカインの新たな機能と生命現象 サイトカインによるシグナル伝達 TLR/IL-1Rファミリーによるシグナル伝達, 河合 太郎,審良 静男, 実験医学, (株)羊土社, Vol. 18, No. 15, p. 2023-2026, 2000/09
  • IL-18レセプターとしてのIL-1Rrp, 星野 克明,審良 静男, 臨床免疫, (有)科学評論社, Vol. 34, No. 1, p. 120-123, 2000/07
  • Roles of STAT3 defined by tissue-specific gene targeting, Shizuo Akira, Oncogene, Nature Publishing Group, Vol. 19, No. 21, p. 2607-2611, 2000/05/15
  • The role of IL-18 in innate immunity, Shizuo Akira, Current Opinion in Immunology, Current Biology Ltd, Vol. 12, No. 1, p. 59-63, 2000/02/01
  • Impairment of natural killer cytotoxic activity and interferon γ production in CCAAT/enhancer binding protein γ-deficient mice, Tsuneyasu Kaisho,Hiroko Tsutsui,Takashi Tanaka,Tohru Tsujimura,Kiyoshi Takeda,Taro Kawai,Nobuaki Yoshida,Kenji Nakanishi,Shizuo Akira, Journal of Experimental Medicine, Vol. 190, No. 11, p. 1573-1581, 1999/12/06
  • T1/ST2欠損マウスの作成と解析, 坂尾 宣充,星野 克明,柏村 信一郎,中西 憲司,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 29, p. 281-281, 1999/10
  • MyD88は様々な細菌菌体成分に対する反応に必須である, 竹内 理,星野 克明,足達 治,小川 知彦,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 29, p. 237-237, 1999/10
  • TLR4(Toll like receptor 4)欠損マウスの作成と解析, 星野 克明,竹内 理,河合 太郎,山条 秀樹,小川 知彦,竹田 潔,審良 静男, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 29, p. 198-198, 1999/10
  • IL-18による好塩基球からのIL-4,IL-13の産生誘導, 善本 知広,福井 久恵,筒井 ひろ子,冨永 幸司,星野 克明,岡村 春樹,審良 静男,中西 憲司, 日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, Vol. 29, p. 80-80, 1999/10
  • Functional roles of STAT family proteins: Lessons from knockout mice, Shizuo Akira, Stem Cells, AlphaMed Press, Vol. 17, No. 3, p. 138-146, 1999
  • 【アポトーシス】 アポトーシスの分子細胞生物学 サイトカインによるアポトーシスのシグナル伝達, 河合 太郎,審良 静男, 医学のあゆみ, 医歯薬出版(株), Vol. 187, No. 5, p. 329-332, 1998/10
  • IL-1Rrp(IL-18レセプター)欠損マウスの作成と解析, 星野 克明,竹田 潔,筒井 ひろ子,中西 憲司,審良 静男, 日本臨床免疫学会会誌, 日本臨床免疫学会, No. 26回抄録集, p. 281-281, 1998/10
  • STAT6: Its role in interleukin 4-mediated biological functions, Kiyoshi Takeda,Tadamitsu Kishimoto,Shizuo Akira, Journal of Molecular Medicine, Vol. 75, No. 5, p. 317-326, 1997
  • Role of interleukin-6 in macrophage function, Shizuo Akira,Tadamitsu Kishimoto, Current Opinion in Hematology, Lippincott Williams and Wilkins, Vol. 3, No. 1, p. 87-93, 1996
  • Interleukin-6 family of cytokines and gp130, T. Kishimoto,S. Akira,M. Narazaki,T. Taga, Blood, Vol. 86, No. 4, p. 1243-1254, 1995
  • Cytokine signal transduction, Tadamitsu Kishimoto,Tetsuya Taga,Shizuo Akira, Cell, Vol. 76, No. 2, p. 253-262, 1994/01/28
  • Generation and analysis of NF-IL6 and NF-IL6.BETA. deficient mice by gene targeting., 田中貴志,藤原弘士,末松佐知子,長束俊治,松阪泰二,吉田進昭,岸本忠三,審良静男, 日本免疫学会総会・学術集会記録, Vol. 23, 1993/10
  • Synergistic activation by transcription factors, NF-IL6 and NF-.KAPPA.B of the expression of the IL-6 and IL-8 genes: direct protein-protein interaction between NF-IL6 and the p65 subunit., 松阪泰二,西尾幸浩,向田直史,松島網治,岸本忠三,審良静男, 日本免疫学会総会・学術集会記録, Vol. 23, 1993/10
  • Production of autoimmune diseases by the transfer of IL-6 transgenic bone marrow., 松阪泰二,末松佐知子,審良静男,松田正,平野俊夫,青笹克之,宮崎純一,山村研一,岸本忠三, 日本免疫学会総会・学術集会記録, Vol. 20, 1990/10
  • Biological and clinical aspects of interleukin 6, Toshio Hirano,Shizuo Akira,Tetsuya Taga,Tadamitsu Kishimoto, Immunology Today, Vol. 11, No. C, p. 443-449, 1990
  • Plasmacytosis in IL-6 transgenic mice., 末松佐知子,松田正,審良静男,青笹克之,中野直子,宮崎純一,山村研一,平野俊夫,岸本忠三, 日本免疫学会総会・学術集会記録, Vol. 19, 1989/10
  • Interleukin 6 and its receptor, Toshio Hirano,Tetsuya Taga,Katsuhiko Yamasaki,Tadashi Matsuda,Sachiko Suematsu,Bo Tang,Yukihiko Hirata,Hideo Yawata,Masahiko Hibi,Shunji Natsuka,Shizuo Akira,Kazuyuki Yoshizaki,M. Kawano,Kenichi Yamamura,Tadamitsu Kishimoto, Recent Progress in Cytokine Research, p. 265-285, 1989

Publications

  • エッセンシャル 免疫学 第3版 第2章 自然免疫:感染に対する即時応答/第3章 自然免疫:感染に対する誘導応答, 審良 静男,黒崎 知博,阪口 薫雄,前田 和彦, メディカル・サイエンス・インターナショナル, 2016/08
  • 一個人 プレミアム 腸の免疫力がカギを握る!”新がんワクチン”開発でがんが治る病になる!, 審良 静男, KKベストセラーズ, 2016/03
  • 臨床免疫・アレルギー科 疾患特異的M2マクロファージの分化機構, 佐藤 荘,審良 静男, 科学評論社, 2015/10
  • 月刊Mebio9月号 ”TLRと疾患”, 金丸 央,佐藤 荘,審良 静男, メジカルビュー社, 2015/09
  • 臨床免疫・アレルギー科 疾患特異的M2マクロファージの生体内での役割と分化機構, 佐藤 荘,審良 静男, 科学評論社, 2015/07
  • ここまで明らかになった!尿酸代謝ワールドと高尿酸血症の病態解明 診療と医学の最前線「痛風とNLRP3インフラマソーム」, 齊藤 達哉,三澤 拓馬,審良 静男, メディカルレビュー社, 2015/06
  • 臨床免疫・アレルギー科 インフラマソームの活性化機構, 三澤 拓馬,斎藤 達哉,審良 静男, 科学評論社, 2015/05
  • 炎症と免疫 M2マクロファージ分化とクロマチン制御因子, 佐藤 荘,審良 静男, 先端医学社, 2015/04
  • Annual Review2015 糖尿病・代謝・内分泌 「疾患特異的M2マクロファージとメタボリックシンドローム」, 佐藤 荘,審良 静男, 中外医学社, 2015/01
  • 新しい免疫入門 自然免疫から自然炎症まで, 審良 静男,黒崎 知博, 講談社, 2014/12
  • 感染・炎症・免疫 「疾患特異的M2マクロファージと慢性炎症」, 佐藤 荘,審良 静男, 医薬の門社, 2014/10
  • 炎症と免疫 特集 マクロファージ研究のパラダイムシフト「疾患特異的M2マクロファージの分化とその役割」, 佐藤 荘,審良 静男, 先端医学社, 2014/10
  • 実験医学増刊号 「TLRおよびNLRを介した自然免疫応答」, 齊藤 達哉,審良 静男, 羊土社, 2014/10
  • Surgery Frontie 特集 生体防御における免疫反応の新知見 Ⅱ. 新展開を生じた生体反応の最新情報 「2.Pattern-Recognition Receptorsと胚血症の病態生理」, 國吉 佳奈子,審良 静男, メディカルレビュー社, 2014/09
  • 医学のあゆみ「T細胞におけるRegnase-1を介したあらたな転写後制御機構の解明, 植畑 拓也,審良 静男, 医歯薬出版, 2014/07
  • 血管医学 特集「単球・マクロファージの多様性と病態」1.M2マクロファージ分化の分子制御機構, 佐藤 荘,審良 静男, メディカルレビュー社, 2014/07
  • 医学のあゆみ 第1土曜特集 創刊3000号記念 医学・医療のいまがわかるキーワード2014 免疫 免疫学 ”自然免疫”, 佐藤 荘,審良 静男, 医歯薬出版, 2014/05
  • 臨床免疫・アレルギー科 特集I/免疫グロブリンの体細胞高頻度突然変異とクラススイッチ 解説”NLRP3インフラマソーム活性化における微小管の関与”, 三澤 拓馬,斎藤 達哉,審良 静男, 科学評論社, 2014/04

Awards

  • The 2011 Canada Gairdner International Awards, 2010
  • EMBO 外国人会員, 2010
  • Honorary lifetime member (International Endotoxin and Innate Immunity Society), 2010
  • Avery-Landsteiner Prize, 2010
  • 慶應医学賞, 2010
  • The 2011 Canada Gairdner International Award, 2010
  • EMBO Associate Member, 2010
  • Honorary lifetime member (International Endotoxin and Innate Immunity Society), 2010
  • Avery-Landsteiner Prize, 2010
  • Keio International Medical Science Prize, 2010
  • Fellow of the American Academy of Microbiology, 2009
  • Hans Bloemendal Medal, 2009
  • 文化功労者, 2009
  • 米国科学アカデミー外国人会員, 2009
  • Fellow of the American Academy of Microbiology, 2009
  • Hans Bloemendal Medal, 2009
  • Person of Cultural Merit, 2009
  • Foreign Associate, National Academy of Science, 2009
  • Milstein Award, 2007
  • 恩賜賞・学士院賞, 2007
  • 上原賞, 2007
  • Milstein Award, 2007
  • The Japan Academy Award The Imperial Award, 2007
  • Uehara Prize, 2007
  • william B. Coley Award, 2006
  • 朝日賞, 2006
  • William B Coley Award, 2006
  • Asahi Prize, 2006
  • 紫綬褒章, 2005
  • The Emperor’s Purple Ribbon Medal, 2005
  • Robert Koch Prize, 2004
  • 高松宮妃癌研究基金学術賞, 2004
  • Robert Koch Prize, 2004
  • Prize of Pricess Takamatsu Cancer Reseach Fund, 2004
  • 武田医学賞, 2003
  • Takeda Medical Prize, 2003
  • 大阪科学賞, 2002
  • Osaka Science Prize, 2002
  • 野口英世記念医学賞, 2001
  • Hideyo Noguchi Prize, 2001
  • 井上学術賞, 2000
  • Inoue Prize for Science, 2000