IL-33 Reduces Saturated Fatty Acid Accumulation in Mouse Atherosclerotic Foci.

Yukako Hosomi, Takuro Okamura, Kimiko Sakai, Hiroki Yuge, Takashi Yoshimura, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Takashi Satoh, Shizuo Akira, Masahide Hamaguchi, Michiaki Fukui

Nutrients　Vol. 16　No. 8　2024/04/17　Research paper (scientific journal)

Decoding Toll-like receptors: Recent insights and perspectives in innate immunity.

Taro Kawai, Moe Ikegawa, Daisuke Ori, Shizuo Akira

Immunity　Vol. 57　No. 4　p. 649-673　2024/04/09　Research paper (scientific journal)

TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for TLR-induced cytokine production in macrophages

Tanveer Ali, Huong Minh Nguyen, Naeem Abbas, Osamu Takeuchi, Shizuo Akira, Toshihiko Suzuki, Goro Matsuzaki, Giichi Takaesu

International Immunology　2024/04/03　Research paper (scientific journal)

The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.

Anhao Liu, Mikihito Hayashi, Yujin Ohsugi, Sayaka Katagiri, Shizuo Akira, Takanori Iwata, Tomoki Nakashima

Nature communications　Vol. 15　No. 1　p. 2707-2707　2024/03/28　Research paper (scientific journal)

The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy.

Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Ramya Masand, Michael J Holtzman, Yong Zhang, John Lydon, Shizuo Akira, Kelle H Moley, Ramakrishna Kommagani

bioRxiv : the preprint server for biology　2024/03/20

A new therapeutic target for systemic lupus erythematosus: the current landscape for drug development of a toll-like receptor 7/8 antagonist through academia-industry-government collaboration.

Yoshiya Tanaka, Fumitoshi Tago, Naoto Yamakawa, Mari Aoki, Takuya Yagi, Shizuo Akira

Immunological medicine　Vol. 47　No. 1　p. 24-29　2024/03　Research paper (scientific journal)

CGRP sensory neurons promote tissue healing via neutrophils and macrophages.

Yen-Zhen Lu, Bhavana Nayer, Shailendra Kumar Singh, Yasmin K. Alshoubaki, Elle Yuan, Anthony J. Park, Kenta Maruyama, Shizuo Akira, Mikaël M. Martino

Nature　2024/03　Research paper (scientific journal)

Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity.

Junya Okabe, Takahiro Kodama, Yu Sato, Satoshi Shigeno, Takayuki Matsumae, Kazuma Daiku, Katsuhiko Sato, Teppei Yoshioka, Minoru Shigekawa, Masaya Higashiguchi, Shogo Kobayashi, Hayato Hikita, Tomohide Tatsumi, Toru Okamoto, Takashi Satoh, Hidetoshi Eguchi, Shizuo Akira, Tetsuo Takehara

Journal of experimental & clinical cancer research : CR　Vol. 42　No. 1　p. 262-262　2023/10/09　Research paper (scientific journal)

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome.

Hachiro Konaka, Yasuhiro Kato, Toru Hirano, Kohei Tsujimoto, JeongHoon Park, Taro Koba, Wataru Aoki, Yusei Matsuzaki, Masayasu Taki, Shohei Koyama, Eri Itotagawa, Tatsunori Jo, Takehiro Hirayama, Taro Kawai, Ken J Ishii, Mitsuyoshi Ueda, Shigehiro Yamaguchi, Shizuo Akira, Takayoshi Morita, Yuichi Maeda, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Hyota Takamatsu, Atsushi Kumanogoh

The EMBO journal　Vol. 42　No. 20　2023/09/04　Research paper (scientific journal)

マウス急性拘束ストレスモデルでの神経炎症とうつ様症状における膜結合型PGE2合成酵素-1の役割

松尾 由理, 平田 浩実, 坂原 在, 審良 静男, 植松 智, 高橋 達雄

日本神経精神薬理学会年会プログラム・抄録集　Vol. 53回　p. 172-172　2023/09

Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity.

Yuichi Mitsui, Tatsuya Suzuki, Kanako Kuniyoshi, Jun Inamo, Kensuke Yamaguchi, Mariko Komuro, Junya Watanabe, Mio Edamoto, Songling Li, Tsukasa Kouno, Seiya Oba, Tadashi Hosoya, Kentaro Masuhiro, Yujiro Naito, Shohei Koyama, Nobuo Sakaguchi, Daron M Standley, Jay W Shin, Shizuo Akira, Shinsuke Yasuda, Yasunari Miyazaki, Yuta Kochi, Atsushi Kumanogoh, Toru Okamoto, Takashi Satoh

Immunity　Vol. 56　No. 8　p. 1939-1954　2023/08/08　Research paper (scientific journal)

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, Yoshio Yamauchi, Yumiko Tsukamoto, Takeshi Ichinohe, Etsuko Fujita, Ryosuke Hiranuma, Ryutaro Fukui, Yoichi Furukawa, Toshio Kitamura, Toshiyuki Takai, Arinobu Tojo, Mamitaro Ohtsuki, Umeharu Ohto, Toshiyuki Shimizu, Manabu Ozawa, Nobuaki Yoshida, Toshiaki Isobe, Eicke Latz, Kojiro Mukai, Tomohiko Taguchi, Hiroaki Hemmi, Shizuo Akira, Kensuke Miyake

Journal of Experimental Medicine　Vol. 220　No. 9　2023/07/18　Research paper (scientific journal)

TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.

Eui-Soon Park, Hyoeun Jeon, Nari Lee, Jiyeon Yu, Hye-Won Park, Takashi Satoh, Shizuo Akira, Tatsuo Furuyama, Chul-Ho Lee, Jong-Soon Choi, Jaerang Rho

The EMBO journal　Vol. 42　No. 13　2023/07/03　Research paper (scientific journal)

Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis.

Sen Hee Tay, Olga Zharkova, Hui Yin Lee, Michelle Min Xuan Toh, Eshele Anak Libau, Teja Celhar, Sriram Narayanan, Patricia Jennifer Ahl, Wei Yee Ong, Craig Joseph, Jeffrey Chun Tatt Lim, Lingzhi Wang, Anis Larbi, Shen Liang, Aisha Lateef, Shizuo Akira, Lieng Hsi Ling, Thomas Paulraj Thamboo, Joe Poh Seng Yeong, Bernett Teck Kwong Lee, Steven W Edwards, Helen L Wright, Paul Anthony MacAry, John E Connolly, Anna-Marie Fairhurst

Rheumatology (Oxford, England)　2023/06/21　Research paper (scientific journal)

MGIT-seqによる非結核性抗酸菌における菌株と薬剤耐性の同定

新津 敬之, 福島 清春, 松本 悠希, 松木 隆則, 齋藤 晴子, 元岡 大祐, 小向 翔, 福井 絵理子, 山内 寿里, 新田 忠義, 安部 祐子, 鍋島 弘嗣, 永濱 康晴, 新居 卓郎, 辻野 和之, 三木 啓資, 北田 清悟, 熊ノ郷 淳, 審良 静男, 中村 昇太, 木田 博

結核　Vol. 98　No. 4　p. 140-140　2023/06

Interleukin-33 facilitates liver regeneration through serotonin-involved gut-liver axis.

Yankai Wen, Christoph Emontzpohl, Long Xu, Constance L Atkins, Jong-Min Jeong, Yang Yang, Kangho Kim, Chuan Wu, Shizuo Akira, Cynthia Ju

Hepatology (Baltimore, Md.)　Vol. 77　No. 5　p. 1580-1592　2023/05/01　Research paper (scientific journal)

Keratinocyte Regnase-1, a Downregulator of Skin Inflammation, Contributes to Protection against Tumor Promotion by Limiting Cyclooxygenase-2 Expression.

Hiroyuki Morisaka, Mikiro Takaishi, Shizuo Akira, Shigetoshi Sano

The Journal of investigative dermatology　Vol. 143　No. 5　p. 731-739　2023/05　Research paper (scientific journal)

TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells

Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Ken J. Ishii, Shizuo Akira, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa

International Immunopharmacology　Vol. 117　p. 109852-109852　2023/04　Research paper (scientific journal)

MGIT-seq for the Identification of Nontuberculous Mycobacteria and Drug Resistance: a Prospective Study.

Kiyoharu Fukushima, Yuki Matsumoto, Takanori Matsuki, Haruko Saito, Daisuke Motooka, Sho Komukai, Eriko Fukui, June Yamuchi, Tadayoshi Nitta, Takayuki Niitsu, Yuko Abe, Hiroshi Nabeshima, Yasuharu Nagahama, Takuro Nii, Kazuyuki Tsujino, Keisuke Miki, Seigo Kitada, Atsushi Kumanogoh, Shizuo Akira, Shota Nakamura, Hiroshi Kida

Journal of clinical microbiology　Vol. 61　No. 4　2023/03/22　Research paper (scientific journal)

Breaking self-regulation of Regnase-1 promotes its own protein expression.

Kitiya Piboonprai, Arthur Millius, Mayuko Shimoda, Hiroki Tanaka, Shizuo Akira, Kazuhiko Maeda

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 28　No. 5　p. 383-389　2023/02/23　Research paper (scientific journal)

The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells.

Hideki Amano, Koji Eshima, Yoshiya Ito, Masaki Nakamura, Hidero Kitasato, Fumihiro Ogawa, Kanako Hosono, Kazuya Iwabuchi, Satoshi Uematsu, Shizuo Akira, Shuh Narumiya, Masataka Majima

Cardiovascular research　Vol. 119　No. 5　p. 1218-1233　2022/08/20　Research paper (scientific journal)

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

Seiya Oura, Toshiaki Hino, Takashi Satoh, Taichi Noda, Takayuki Koyano, Ayako Isotani, Makoto Matsuyama, Shizuo Akira, Kei-ichiro Ishiguro, Masahito Ikawa

PLOS Genetics　Vol. 18　No. 6　p. e1010241-e1010241　2022/06/01　Research paper (scientific journal)

The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model

Yukihiro Hiramatsu, Koichiro Suzuki, Takashi Nishida, Naoki Onoda, Takashi Satoh, Shizuo Akira, Masahito Ikawa, Hiroko Ikeda, Junzo Kamei, Sandra Derouiche, Makoto Tominaga, Yasuhiko Horiguchi

mBio　2022/03/31　Research paper (scientific journal)

マウス急性拘束ストレスモデルでの神経炎症とうつ様症状におけるPGE2合成酵素の役割

松尾 由理, 川端 悠太, 平田 浩実, 坂原 在, 植松 智, 審良 静男, 高橋 達雄

日本薬学会年会要旨集　Vol. 142年会　p. 26L-am07　2022/03

B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice.

Michelle S J Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A Katharina Simon, Jelena S Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J Ishii, Cevayir Coban

The Journal of experimental medicine　Vol. 219　No. 2　2022/02/07　Research paper (scientific journal)

The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.

Tetsuya Hyodo, Yoshiya Ito, Kanako Hosono, Satoshi Uematsu, Shizuo Akira, Masataka Majima, Akira Takeda, Hideki Amano

In vivo (Athens, Greece)　Vol. 36　No. 5　p. 2061-2073　2022　Research paper (scientific journal)

Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.

Takahiro Kawasaki, Fuminori Sugihara, Kiyoharu Fukushima, Takanori Matsuki, Hiroshi Nabeshima, Tomohisa Machida, Yuichi Mitsui, Saki Fujimura, Rio Sagawa, Lee Gaheun, Kanako Kuniyoshi, Hiroki Tanaka, Masashi Narazaki, Atsushi Kumanogoh, Shizuo Akira, Takashi Satoh

Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 26　2021/06/29　Research paper (scientific journal)

Novel insights into the pathogenesis of lung fibrosis: the RBM7-NEAT1-CXCL12-SatM axis at fibrosis onset.

Kiyoharu Fukushima, Shizuo Akira

International immunology　2021/06/24　Research paper (scientific journal)

Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

Yoshihiro Takasato, Yosuke Kurashima, Masahiro Kiuchi, Kiyoshi Hirahara, Sayuri Murasaki, Fujimi Arai, Kumi Izawa, Ayako Kaitani, Kaoru Shimada, Yukari Saito, Shota Toyoshima, Miho Nakamura, Kumiko Fujisawa, Yoshimichi Okayama, Jun Kunisawa, Masato Kubo, Naoki Takemura, Satoshi Uematsu, Shizuo Akira, Jiro Kitaura, Takao Takahashi, Toshinori Nakayama, Hiroshi Kiyono

Mucosal Immunology　Vol. 14　No. 3　p. 640-651　2021/05　Research paper (scientific journal)

Control of RNA Stability in Immunity.

Shizuo Akira, Kazuhiko Maeda

Annual review of immunology　Vol. 39　p. 481-509　2021/04/26　Research paper (scientific journal)

Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice.

Kirsten Sieverding, Johannes Ulmer, Clara Bruno, Takashi Satoh, William Tsao, Axel Freischmidt, Shizuo Akira, Philip C Wong, Albert C Ludolph, Karin M Danzer, Christian S Lobsiger, David Brenner, Jochen H Weishaupt

Experimental neurology　Vol. 335　p. 113496-113496　2021/01　Research paper (scientific journal)

Rhodobacter azotoformans LPS (RAP99-LPS) Is a TLR4 Agonist That Inhibits Lung Metastasis and Enhances TLR3-Mediated Chemokine Expression.

Kaoru Murakami, Daisuke Kamimura, Rie Hasebe, Mona Uchida, Nobuya Abe, Reiji Yamamoto, Jing-Jing Jiang, Yasuhiro Hidaka, Yuko Nakanishi, Shuzo Fujita, Yuki Toda, Nobuhiro Toda, Hiroki Tanaka, Shizuo Akira, Yuki Tanaka, Masaaki Murakami

Frontiers in immunology　Vol. 12　p. 675909-675909　2021　Research paper (scientific journal)

JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.

Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P Hutchins, Miguel A Esteban, Baoming Qin

Nature communications　Vol. 11　No. 1　p. 5061-5061　2020/10/08　Research paper (scientific journal)

Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.

Jiegen Chen, Josepmaria Argemi, Gemma Odena, Ming-Jiang Xu, Yan Cai, Veronica Massey, Austin Parrish, Rajanikanth Vadigepalli, Jose Altamirano, Joaquin Cabezas, Pere Gines, Juan Caballeria, Natasha Snider, Pau Sancho-Bru, Shizuo Akira, Ivan Rusyn, Bin Gao, Ramon Bataller

Scientific reports　Vol. 10　No. 1　p. 15558-15558　2020/09/23　Research paper (scientific journal)

肺線維症 新規治療に関する基礎研究 新規マクロファージsubset同定とその遊走を介した線維化制御

福島 清春, 佐藤 荘, 木田 博, 熊ノ郷 淳, 審良 静男

日本呼吸器学会誌　Vol. 9　No. 増刊　p. 139-139　2020/08

mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression.

Takayuki Imanishi, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Shizuo Akira, Takashi Saito

Cell reports　Vol. 32　No. 3　p. 107911-107911　2020/07/21　Research paper (scientific journal)

Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages

Kenta Maruyama, Hiroyasu Kidoya, Naoki Takemura, Erika Sugisawa, Osamu Takeuchi, Takeshi Kondo, Mohammed Mansour Abbas Eid, Hiroki Tanaka, Mikaël M. Martino, Nobuyuki Takakura, Yasunori Takayama, Shizuo Akira, Alexis Vandenbon, Yutaro Kumagai

Cell Reports　Vol. 32　No. 2　p. 107906-107906　2020/07　Research paper (scientific journal)

Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling.

Ziad Julier, Rezvan Karami, Bhavana Nayer, Yen-Zhen Lu, Anthony J Park, Kenta Maruyama, Gisela A Kuhn, Ralph Müller, Shizuo Akira, Mikaël M Martino

Science advances　Vol. 6　No. 24　2020/06　Research paper (scientific journal)

Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.

Kiyoharu Fukushima, Takashi Satoh, Fuminori Sugihara, Yuki Sato, Toru Okamoto, Yuichi Mitsui, Sachiyo Yoshio, Songling Li, Satoshi Nojima, Daisuke Motooka, Shota Nakamura, Hiroshi Kida, Daron M Standley, Eiichi Morii, Tatsuya Kanto, Motoko Yanagita, Yoshiharu Matsuura, Takashi Nagasawa, Atsushi Kumanogoh, Shizuo Akira

Immunity　Vol. 52　No. 3　p. 542-556　2020/03/17　Research paper (scientific journal)

Regnase-1 degradation is crucial for IL-33- and IL-25-mediated ILC2 activation.

Kazufumi Matsushita, Hiroki Tanaka, Koubun Yasuda, Takumi Adachi, Ayumi Fukuoka, Shoko Akasaki, Atsuhide Koida, Etsushi Kuroda, Shizuo Akira, Tomohiro Yoshimoto

JCI insight　Vol. 5　No. 4　2020/02/27　Research paper (scientific journal)

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice.

Clara Bruno, Kirsten Sieverding, Axel Freischmidt, Takashi Satoh, Paul Walther, B Mayer, Albert C Ludolph, Shizuo Akira, Deniz Yilmazer-Hanke, Karin M Danzer, Christian S Lobsiger, David Brenner, Jochen H Weishaupt

Brain communications　Vol. 2　No. 2　2020　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow

Ryo Takahashi, Hideki Amano, Yoshiya Ito, Koji Eshima, Takefumi Satoh, Masatsugu Iwamura, Masaki Nakamura, Hidero Kitasato, Satoshi Uematsu, Joan Raouf, Per-Johan Jakobsson, Shizuo Akira, Masataka Majima

Biomedicine & Pharmacotherapy　Vol. 121　p. 109581-109581　2020/01　Research paper (scientific journal)

Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts.

Shigemiki Omiya, Yosuke Omori, Manabu Taneike, Tomokazu Murakawa, Jumpei Ito, Yohei Tanada, Kazuhiko Nishida, Osamu Yamaguchi, Takashi Satoh, Ajay M Shah, Shizuo Akira, Kinya Otsu

Circulation　Vol. 141　No. 8　p. 667-677　2020/01　Research paper (scientific journal)

Beclin 1 regulates recycling endosome and is required for skin development in mice.

Noguchi S, Honda S, Saitoh T, Matsumura H, Nishimura E, Akira S, Shimizu S

Commun Biol.　Vol. 1　No. 37　2020/01　Research paper (scientific journal)

Regulation of immune responses by endoribonuclease Regnase-1

Shizuo Akira

2019/11　Research paper (other academic)

ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity

Masatoshi Momota, Patrick Lelliott, Atsuko Kubo, Takato Kusakabe, Kouji Kobiyama, Etsushi Kuroda, Yumiko Imai, Shizuo Akira, Cevayir Coban, Ken J Ishii

International Immunology　Vol. 32　No. 3　p. 203-212　2019/10/20　Research paper (scientific journal)

Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses

審良 静男

2019/10　Research paper (other academic)

Endoribonuclease Regnase-1 controls inflammation and immune responses

審良 静男

2019/10　Research paper (other academic)

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant.

Lee MSJ, Natsume-Kitatani Y, Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, Kobiyama K, Kuroda E, Onishi M, Marichal T, Ise W, Inoue T, Kurosaki T, Mizuguchi K, Akira S, Ishii KJ, Coban C

European journal of immunology　Vol. 49　No. 9　p. 1433-1440　2019/09　Research paper (scientific journal)

免疫・炎症応答に関わるリボヌクレアーゼReganase-1

審良 静男

2019/08　Research paper (other academic)

転写因子BATF2のIL-12p40発現促進機構

金丸 央, 佐藤 荘, 福島 聡, 尹 浩信, 審良 静男

日本がん免疫学会総会プログラム・抄録集　Vol. 23回　p. 105-105　2019/07

免疫・炎症応答に関わるリボヌクレアーゼReganase-1

審良 静男

2019/07　Research paper (other academic)

Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses

審良 静男

2019/06　Research paper (other academic)

The role of endoribonulease Regnase-1 in inflammation and immune responses

審良 静男

2019/06　Research paper (other academic)

Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.

Hideki Sanjo, Jun Nakayama, Takahiro Yoshizawa, Hans Joerg Fehling, Shizuo Akira, Shinsuke Taki

Journal of immunology (Baltimore, Md. : 1950)　Vol. 203　No. 4　p. 783-788　2019/06　Research paper (scientific journal)

Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice.

Rika Kitazume-Taneike, Manabu Taneike, Shigemiki Omiya, Tomofumi Misaka, Kazuhiko Nishida, Osamu Yamaguchi, Shizuo Akira, Michael J Shattock, Yasushi Sakata, Kinya Otsu

Biochemical and biophysical research communications　Vol. 515　No. 3　p. 442-447　2019/05　Research paper (scientific journal)

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

Hiroki Tanaka, Yasunobu Arima, Daisuke Kamimura, Yuki Tanaka, Noriyuki Takahashi, Takuya Uehata, Kazuhiko Maeda, Takashi Satoh, Masaaki Murakami, Shizuo Akira

The Journal of experimental medicine　Vol. 216　No. 6　p. 1431-1449　2019/05　Research paper (scientific journal)

腫瘍免疫における転写因子BATF2のIL-12p40発現促進の機序について

金丸 央, 佐藤 荘, 福島 聡, 尹 浩信, 審良 静男

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集　Vol. 35回　p. 123-123　2019/04

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.

DeVorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, McNamara E, Huang H, Kim P, Zacharias LG, Mizushima N, Saitoh T, Akira S, Beckham W, Lorzadeh A, Moksa M, Cao Q, Murthy A, Hirst M, DeBerardinis RJ, Lum JJ

2019/04　Research paper (scientific journal)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.

Hiroyasu Kidoya, Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira, Nobuyuki Takakura

Nature communications　Vol. 10　No. 1　p. 1072-1072　2019/03/06　Research paper (scientific journal)

Innate immunity in allergy.

Maeda K, Caldez MJ, Akira S

Allergy　2019/03

RNA結合蛋白と炎症

審良 静男

2019/03　Research paper (other academic)

Regnase-1:炎症と免疫応答に重要な核酸分解酵素

審良 静男

2019/03　Research paper (other academic)

The control of inflammatory and immune responses by the endoribonuclease Regnase-1

Shizuo Akira

2019/03　Research paper (international conference proceedings)

Role of Akirin1 in the regulation of skeletal muscle fiber-type switch.

Rao VV, Sangiah U, Mary KA, Akira S, Mohanty A

J Cell Biochem.　2019/02　Research paper (scientific journal)

The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.

Müller CP, Chu C, Qin L, Liu C, Xu B, Gao H, Ruggeri B, Hieber S, Schneider J, Jia T, Tay N, Akira S, Satoh T, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Artiges E, Lemaitre H, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Bakalkin G, Liu Y, Desrivières S, Elliott P, Eulenburg V, Levy D, Crews F, Schumann G

Cereb Cortex.　2019/02　Research paper (scientific journal)

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.

Takayuki Imanishi, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, Takashi Saito

Life science alliance　Vol. 2　No. 1　2019/02　Research paper (scientific journal)

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice.

David Brenner, Kirsten Sieverding, Clara Bruno, Patrick Lüningschrör, Eva Buck, Simon Mungwa, Lena Fischer, Sarah J Brockmann, Johannes Ulmer, Corinna Bliederhäuser, Clémentine E Philibert, Takashi Satoh, Shizuo Akira, Séverine Boillée, Benjamin Mayer, Michael Sendtner, Albert C Ludolph, Karin M Danzer, Christian S Lobsiger, Axel Freischmidt, Jochen H Weishaupt

The Journal of experimental medicine　Vol. 216　No. 2　p. 267-278　2019/02　Research paper (scientific journal)

Towards understanding the mechanism of lung fibrosis

Shizuo Akira

2019/02　Research paper (international conference proceedings)

RNA binding protein RBM7 and fibrosis

Shizuo Akira

2019/02　Research paper (other academic)

Beclin 1 regulates recycling endosome and is required for skin development in mice.

Saori Noguchi, Shinya Honda, Tatsuya Saitoh, Hiroyuki Matsumura, Emi Nishimura, Shizuo Akira, Shigeomi Shimizu

Communications biology　Vol. 2　p. 37-37　2019/01　Research paper (scientific journal)

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity.

Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N

Dev Cell.　Vol. 48　No. 2　p. 151-166　2019/01　Research paper (scientific journal)

USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation.

Shinji Kusakabe, Tatsuya Suzuki, Yukari Sugiyama, Saori Haga, Kanako Horike, Makoto Tokunaga, Junki Hirano, He Zhang, David Virya Chen, Hanako Ishiga, Yasumasa Komoda, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masahito Ikawa, Takashi Satoh, Shizuo Akira, Tomohisa Tanaka, Kohji Moriishi, Moto Fukai, Akinobu Taketomi, Sachiyo Yoshio, Tatsuya Kanto, Tetsuro Suzuki, Toru Okamoto, Yoshiharu Matsuura

Journal of virology　Vol. 93　No. 6　2019/01　Research paper (scientific journal)

Understanding the molecular mechanism of lung fibrosis

Shizuo Akira

2019/01

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.

Chongye Fang, Xianbin Cai, Shuhei Hayashi, Shumei Hao, Haruhiko Sakiyama, Xuanjun Wang, Qin Yang, Shizuo Akira, Shuhei Nishiguchi, Noriko Fujiwara, Hiroko Tsutsui, Jun Sheng

Biochimica et biophysica acta. Molecular and cell biology of lipids　Vol. 1864　No. 3　p. 271-280　2018/12　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.

Yuri Ikeda-Matsuo, Hajime Miyata, Tomoko Mizoguchi, Eisaku Ohama, Yasuhito Naito, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasaki, Mitsuo Tanabe

Neurobiology of disease　Vol. 124　p. 81-92　2018/11　Research paper (scientific journal)

Understanding the molecular mechanism of lung fibrosis

Shizuo Akira

2018/11

Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.

Yasuharu Nagahama, Mayuko Shimoda, Guoliang Mao, Shailendra Kumar Singh, Yuuki Kozakai, Xin Sun, Daisuke Motooka, Shota Nakamura, Hiroki Tanaka, Takashi Satoh, Kazuhiko Maeda, Shizuo Akira

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 43　p. 11036-11041　2018/10/23　Research paper (scientific journal)

Toll-Like Receptor 9 Deficiency Breaks Tolerance to RNA-Associated Antigens and Up-Regulates Toll-Like Receptor 7 Protein in Sle1 Mice.

Teja Celhar, Hiroko Yasuga, Hui Yin Lee, Olga Zharkova, Shubhita Tripathi, Susannah I Thornhill, Hao K Lu, Bijin Au, Lina H K Lim, Thomas P Thamboo, Shizuo Akira, Edward K Wakeland, John E Connolly, Anna-Marie Fairhurst

Arthritis & rheumatology (Hoboken, N.J.)　Vol. 70　No. 10　p. 1597-1609　2018/10　Research paper (scientific journal)

Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin.

Adriana Flores-Langarica, Charlotte Cook, Katarzyna Müller Luda, Emma K Persson, Jennifer L Marshall, Nonantzin Beristain-Covarrubias, Juan Carlos Yam-Puc, Madelene Dahlgren, Jenny J Persson, Satoshi Uematsu, Shizuo Akira, Ian R Henderson, Bengt Johansson Lindbom, William Agace, Adam F Cunningham

Frontiers in immunology　Vol. 9　p. 2409-2409　2018/10　Research paper (scientific journal)

Infection with flaviviruses requires BCLXL for cell survival.

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C S Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuura

PLoS pathogens　Vol. 14　No. 9　2018/09　Research paper (scientific journal)

The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.

Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M

iScience.　2018/08　Research paper (scientific journal)

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice

Nobuyuki Nishizawa, Yoshiya Ito, Koji Eshima, Hirotoki Ohkubo, Ken Kojo, Tomoyoshi Inoue, Joan Raouf, Per-Johan Jakobsson, Satoshi Uematsu, Shizuo Akira, Shuh Narumiya, Masahiko Watanabe, Masataka Majima

Journal of Hepatology　Vol. 69　No. 1　p. 110-120　2018/07/01　Research paper (scientific journal)

Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model.

Eiko Saijou, Yutaka Enomoto, Michitaka Matsuda, Cindy Yuet-Yin Kok, Shizuo Akira, Minoru Tanaka, Atsushi Miyajima

Hepatology communications　Vol. 2　No. 6　p. 703-717　2018/06　Research paper (scientific journal)

Hu antigen r regulates antiviral innate immune responses through the stabilization of mRNA for polo-like kinase 2

Takuya Sueyoshi, Takumi Kawasaki, Yuichi Kitai, Daisuke Ori, Shizuo Akira, Taro Kawai

Journal of Immunology　Vol. 200　No. 11　p. 3814-3824　2018/06/01　Research paper (scientific journal)

Regnase-1, an Immunomodulator, Limits the IL-36/IL-36R Autostimulatory Loop in Keratinocytes to Suppress Skin Inflammation

Mikiro Takaishi, Takashi Satoh, Shizuo Akira, Shigetoshi Sano

Journal of Investigative Dermatology　Vol. 138　No. 6　p. 1439-1442　2018/06/01　Research paper (scientific journal)

BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation

Hisashi Kanemaru, Fumihiro Yamane, Hiroki Tanaka, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira

International Immunology　Vol. 30　No. 6　p. 255-265　2018/05/24　Research paper (scientific journal)

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis

Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S. Apte, Raghav Sehgal, Britney Johnson, Gaya K. Amarasinghe, Miguel P. Soares, Takashi Satoh, Shizuo Akira, Tsonwin Hai, Cristina De Guzman Strong, Karine Auclair, Thomas P. Roddy, Scott A. Biller, Marko Jovanovic, Eynav Klechevsky, Kelly M. Stewart, Gwendalyn J. Randolph, Maxim N. Artyomov

Nature　Vol. 556　No. 7702　p. 501-504　2018/04/26　Research paper (scientific journal)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

Okiru Komine, Hirofumi Yamashita, Noriko Fujimori-Tonou, Masato Koike, Shijie Jin, Yasuhiro Moriwaki, Fumito Endo, Seiji Watanabe, Satoshi Uematsu, Shizuo Akira, Yasuo Uchiyama, Ryosuke Takahashi, Hidemi Misawa, Koji Yamanaka

Cell Death and Differentiation　Vol. 25　No. 12　p. 1-17　2018/03/22　Research paper (scientific journal)

Noninvasive detection of macrophage activation with single-cell resolution through machine learning

Nicolas Pavillon, Alison J. Hobro, Shizuo Akira, Nicholas I. Smith

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 12　p. E2676-E2685　2018/03/20　Research paper (scientific journal)

Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis

Katsuhiro Nakagawa, Takanori Matsuki, Liang Zhao, Kanako Kuniyoshi, Hiroki Tanaka, Isao Ebina, Kenta J. Yoshida, Hiroshi Nabeshima, Kiyoharu Fukushima, Hisashi Kanemaru, Fumihiro Yamane, Takahiro Kawasaki, Tomohisa Machida, Hisamichi Naito, Nobuyuki Takakura, Takashi Satoh, Shizuo Akira

International Immunology　Vol. 30　No. 2　p. 69-78　2018/03/08　Research paper (scientific journal)

mPGES-1阻害薬のマウス脳梗塞障害改善機序

宿利 美香, 大内 彩子, 内藤 康仁, 岩井 孝志, 渡辺 俊, 尾山 実砂, 植松 智, 審良 静男, Jakobsson Per-Johan, 田辺 光男, 松尾 由理

日本薬学会年会要旨集　Vol. 138年会　No. 3　p. 95-95　2018/03

Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Pavillon N, Hobro AJ, Akira S, Smith NI

Proc Natl Acad Sci U S A.　2018/03　Research paper (scientific journal)

BATF2 activates DUSP2 gene expression and upregulates NF-κB activity via phospho-STAT3 dephosphorylation.

Kanemaru H, Yamane F, Tanaka H, Maeda K, Satoh T, Akira S

Int Immunol.　Vol. 200　No. 8　p. 2987-2999　2018/03　Research paper (scientific journal)

肺線維化と新規マクロファージサブセット

Shizuo Akira

2018/03　Research paper (other academic)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2018/03　Research paper (international conference proceedings)

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner.

Yuki Katayama, Masashi Tachibana, Nozomi Kurisu, Yukako Oya, Yuichi Terasawa, Hiroshi Goda, Kouji Kobiyama, Ken J Ishii, Shizuo Akira, Hiroyuki Mizuguchi, Fuminori Sakurai

Journal of immunology (Baltimore, Md. : 1950)　Vol. 200　No. 8　p. 2987-2999　2018/03　Research paper (scientific journal)

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

Naoki Takemura, Yosuke Kurashima, Yuki Mori, Kazuki Okada, Takayuki Ogino, Hideki Osawa, Hirosih Matsuno, Lamichhane Aayam, Satoshi Kaneto, Eun Jeong Park, Shintaro Sato, Kouta Matsunaga, Yusuke Tamura, Yasuo Ouchi, Yutaro Kumagai, Daichi Kobayashi, Yutaka Suzuki, Yoshichika Yoshioka, Junichi Nishimura, Masaki Mori, Ken J Ishii, Mark E Rothenberg, Hiroshi Kiyono, Shizuo Akira, Satoshi Uematsu

Science translational medicine　Vol. 10　No. 429　2018/02/21　Research paper (scientific journal)

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.

Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M

J Hepatol.　2018/02　Research paper (scientific journal)

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S

Sci Transl Med.　2018/02　Research paper (scientific journal)

マクロファージ・単球サブセットと病態

審良 静男

2018/02　Research paper (other academic)

マクロファージ・単球サブセットと病態

Shizuo Akira

2018/02　Research paper (other academic)

Batf2 のIL-12p40 発現促進による抗腫瘍効果について

Hisashi Kanemaru

2018/02　Research paper (other academic)

Autophagy limits activation of the inflammasomes.

Michihiro Takahama, Shizuo Akira, Tatsuya Saitoh

Immunological reviews　Vol. 281　No. 1　p. 62-73　2018/01　Research paper (scientific journal)

各種病態にかかわるマクロファージ・単球サブセット

Shizuo Akira

2017/12　Research paper (other academic)

Basic leucine zipper transcription factor ATF-like 2 exhibits an anti-tumor effect through upregulation of IL-12 p40 expression

Hisashi Kanemaru, Fumihiro Yamane, Kiyoharu Fukushima, Takanori Matsuki, Takahiro Kawasaki, Isao Ebina, Kanako Kuniyoshi, Hiroki Tanaka, Kenta Maruyama, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira

2017/12　Research paper (other academic)

Screening of causative genes for fibrosis development in mice

Kiyoharu Fukushima, Takashi Satoh, Atsushi Kumanogoh, Shizuo Akira

2017/12

Role of macrophages in the development of fibrosis

Shizuo Akira

2017/12　Research paper (international conference proceedings)

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways (vol 27, pg 3378, 2017)

Alessandro Sessa, Ernesto Ciabatti, Daniela Drechsel, Luca Massimino, Gaia Colasante, Serena Giannelli, Takashi Satoh, Shizuo Akira, Francois Guillemot, Vania Broccoli

CEREBRAL CORTEX　Vol. 27　No. 12　p. 5715-5715　2017/12　Research paper (scientific journal)

T helper 17 Promotes induction of antigen-specific gut-Mucosal cytotoxic T lymphocytes following adenovirus Vector Vaccination

Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi

FRONTIERS IN IMMUNOLOGY　Vol. 8　2017/11　Research paper (scientific journal)

Identification of a Monocyte Subset Responsible for Lung Fibrosis

Shizuo Akira

2017/11　Research paper (international conference proceedings)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2017/11　Research paper (international conference proceedings)

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Carole Henique, Guillaume Bollee, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, Lea Guyonnet, Francois Gaillard, Helene Lazareth, Charlotte Meyer, Imane Bensaada, Luc Legres, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B. Huber, Laurent Mesnard, Olivia Lenoir, Pierre-Louis Tharaux

NATURE COMMUNICATIONS　Vol. 8　No. 1　2017/11　Research paper (scientific journal)

Macrophage/monocyte subsets involved in a variety of diseases

Shizuo Akira

2017/10　Research paper (international conference proceedings)

各種病態に関わるマクロファージサブセット

Shizuo Akira

2017/10　Research paper (other academic)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2017/10　Research paper (international conference proceedings)

Regnase-1 is a key endoribonuclease that controls the inflammatory and immune responses

Shizuo Akira

2017/10　Research paper (international conference proceedings)

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh

CELL REPORTS　Vol. 20　No. 12　p. 2944-2954　2017/09　Research paper (scientific journal)

Identification of macrophage/monocyte subsets with distinct functions

Shizuo Akira

2017/09　Research paper (international conference proceedings)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2017/09　Research paper (international conference proceedings)

自然免疫と炎症

Shizuo Akira

2017/09　Research paper (other academic)

The antitumor effect of basic leucine zipper transcription factor ATF-like 2 through IL-12 p40 upregulation

Hisashi Kanemaru, Takashi Satoh, Satoshi Fukushima, Hironobu Ihn, Shizuo Akira

2017/09　Research paper (international conference proceedings)

Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages

Hisashi Kanemaru, Fumihiro Yamane, Kiyoharu Fukushima, Takanori Matsuki, Takahiro Kawasaki, Isao Ebina, Kanako Kuniyoshi, Hiroki Tanaka, Kenta Maruyama, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 114　No. 35　p. E7331-E7340　2017/08　Research paper (scientific journal)

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata, Hironori Bando, Youngae Lee, Tatsuya Saitoh, Shizuo Akira, Akiko Iwasaki, Daron M Standley, Tamotsu Yoshimori, Masahiro Yamamoto

Nature immunology　Vol. 18　No. 8　p. 899-910　2017/08　Research paper (scientific journal)

Netrins as prophylactic targets in skeletal diseases: A double-edged sword?

Kenta Maruyama, Naoki Takemura, Mikaël M Martino, Takeshi Kondo, Shizuo Akira

Pharmacological research　Vol. 122　p. 46-52　2017/08　Research paper (scientific journal)

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, Junying Yuan

NATURE COMMUNICATIONS　Vol. 8　No. 1　2017/08　Research paper (scientific journal)

各種病態に関わるマクロファージサブセット

Shizuo Akira

2017/07　Research paper (other academic)

自然免疫の最近の進歩

Shizuo Akira

2017/07　Research paper (other academic)

炎症とマクロファージ・サブセット

Shizuo Akira

2017/07　Research paper (other academic)

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.

Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-Ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga, Shizuo Akira

Cell reports　Vol. 19　No. 13　p. 2730-2742　2017/06/27　Research paper (scientific journal)

Plasmodium products persist in the bone marrow and promote chronic bone loss.

Michelle S J Lee, Kenta Maruyama, Yukiko Fujita, Aki Konishi, Patrick M Lelliott, Sawako Itagaki, Toshihiro Horii, Jing-Wen Lin, Shahid M Khan, Etsushi Kuroda, Shizuo Akira, Ken J Ishii, Cevayir Coban

Science immunology　Vol. 2　No. 12　2017/06/02　Research paper (scientific journal)

An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling

Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier

CELL REPORTS　Vol. 19　No. 13　p. 2853-2866　2017/06　Research paper (scientific journal)

The Control of Inflammatory and immune responses by the endoribonuclease

Shizuo Akira

2017/06　Research paper (international conference proceedings)

Role of selective regulation of non-coding RNA by mammalian mRNA export complex TREX-2

Mayuko Shimoda, Kazuhiko Maeda, Shailendra Singh, Shizuo Akira, Nobuo Sakaguchi

2017/06　Research paper (international conference proceedings)

Regnase1によるmRNA制御

Shizuo Akira

2017/06　Research paper (other academic)

線維症における新規のマクロファージサブタイプの同定

福島 清春, 佐藤 荘, 熊ノ郷 淳, 審良 静男

2017/06

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice

Takumi Kawasaki, Kosuke Ito, Haruhiko Miyata, Shizuo Akira, Taro Kawai

EMBO JOURNAL　Vol. 36　No. 12　p. 1707-1718　2017/06　Research paper (scientific journal)

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways

Alessandro Sessa, Ernesto Ciabatti, Daniela Drechsel, Luca Massimino, Gaia Colasante, Serena Giannelli, Takashi Satoh, Shizuo Akira, Francois Guillemot, Broccoli Vania

CEREBRAL CORTEX　Vol. 27　No. 6　p. 3378-3396　2017/06　Research paper (scientific journal)

Towards understanding the mechanism of fibrosis induced by viral infection

Shizuo Akira

2017/05　Research paper (international conference proceedings)

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase- mediated antiviral response

Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 114　No. 10　p. 2681-2686　2017/03　Research paper (scientific journal)

自然免疫と炎症

審良 静男

2017/03　Research paper (other academic)

Identification of a Monocyte Subset Responsible for Lung Fibrosis

Shizuo Akira

2017/03　Research paper (international conference proceedings)

自然免疫の最近の進歩

審良 静男

2017/02　Research paper (other academic)

G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE(2)

Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama

BLOOD　Vol. 129　No. 5　p. 587-597　2017/02　Research paper (scientific journal)

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING- Dependent Pathway and Reinforce Antitumor Immunity

Yuichi Kitai, Takumi Kawasaki, Takuya Sueyoshi, Kouji Kobiyama, Ken J. Ishii, Jian Zou, Shizuo Akira, Tadashi Matsuda, Taro Kawai

JOURNAL OF IMMUNOLOGY　Vol. 198　No. 4　p. 1649-1659　2017/02　Research paper (scientific journal)

Identification of an atypical monocyte and committed progenitor involved in fibrosis

Takashi Satoh, Katsuhiro Nakagawa, Fuminori Sugihara, Ryusuke Kuwahara, Motooki Ashihara, Fumihiro Yamane, Yosuke Minowa, Kiyoharu Fukushima, Isao Ebina, Yoshichika Yoshioka, Atsushi Kumanogoh, Shizuo Akira

NATURE　Vol. 541　No. 7635　p. 96-+　2017/01　Research paper (scientific journal)

Identification of a Monocyte Subset Responsible for Lung Fibrosis

審良 静男

2017/01　Research paper (international conference proceedings)

Batf2 has an anti-tumor effect through upregulation of IL-12 p40 in tumor-associated macrophages

Hisashi Kanemaru

2017/01　Research paper (international conference proceedings)

Functional diversity of macrophage/monocyte subsets revealed by gene targeting

Shizuo Akira

2017/01　Research paper (international conference proceedings)

Identification of an atypical monocyte and committed progenitor involved in fibrosis

Takashi Satoh, Katsuhiro Nakagawa, Fuminori Sugihara, Ryusuke Kuwahara, Motooki Ashihara, Fumihiro Yamane, Yosuke Minowa, Kiyoharu Fukushima, Isao Ebina, Yoshichika Yoshioka, Atsushi Kumanogoh, Shizuo Akira

NATURE　Vol. 541　No. 7635　p. 96-+　2017/01　Research paper (scientific journal)

KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference

Gunter Schumann, Chunyu Liu, Paul O'Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, Stefan Enroth, Krista Fischer, Jenni Hallfors, Sarah E. Harris, Saskia Hieber, Edith Hofer, Jouke-Jan Hottenga, Asa Johansson, PeterK. Joshi, Niina Kaartinen, Jaana Laitinen, Rozenn Lemaitre, Anu Loukola, Jian'an Luan, Leo-Pekka Lyytikainen, Massimo Mangino, Ani Manichaikul, Hamdi Mbarek, Yuri Milaneschi, Alireza Moayyeri, Kenneth Mukamal, Christopher Nelson, Jennifer Nettleton, Eemil Partinen, Rajesh Rawal, Antonietta Robino, Lynda Rose, Cinzia Sala, Takashi Satoh, Reinhold Schmidt, Katharina Schrautz, Robert Scott, Albert Vernon Smith, John M. Starr, Alexander Teumer, Stella Trompet, Andre G. Uitterlinden, Cristina Venturini, Anne-Claire Vergnaud, Niek Verweij, Veronique Vitart, Dragana Vuckovic, Juho Wedenoja, Loic Yengo, Bing Yu, Weihua Zhang, Jing Hua Zhao, Dorret I. Boomsma, John Chambers, Daniel I. Chasman, Toniolo Daniela, Eco de Geus, Ian Deary, Johan G. Eriksson, Tonu Esko, Volker Eulenburg, Oscar H. Franco, Philippe Froguel, Christian Gieger, Hans J. Grabe, Vilmundur Gudnason, Ulf Gyllensten, Tamara B. Harris, Anna-Liisa Hartikainen, Andrew C. Heath, Lynne Hocking, Albert Hofman, Cornelia Huth, Marjo-Riitta Jarvelin, J. Wouter Jukema, Jaakko Kaprio, Jaspal S. Kooner, Zoltan Kutalik, Jari Lahti, Claudia Langenberg, Terho Lehtimaki, Yongmei Liu, Pamela A. F. Madden, Nicholas Martin, Alanna Morrison, Brenda Penninx, Nicola Pirastu, Bruce Psaty, Olli Raitakari, Paul Ridker, Richard Rose, Jerome I. Rotter, Nilesh J. Samani, Helena Schmidt, Tim D. Spector, David Stott, David Strachan, Ioanna Tzoulaki, Pim van der Harst, Cornelia M. van Duijn, Pedro Marques-Vidal, Peter Vollenweider, Nicholas J. Wareham, John B. Whitfield, James Wilson, Bruce Wolffenbuttel, Georgy Bakalkin, Evangelos Evangelou, Yun Liu, Kenneth M. Rice, Sylvane Desrivieres, Steven A. Kliewer, David J. Mangelsdorf, Christian P. Muller, Daniel Levy, Paul Elliott

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 113　No. 50　p. 14372-14377　2016/12　Research paper (scientific journal)

Regulation of HIV-1 mRNA export by a host TREX-2 component GANP

Mayuko Shimoda

2016/12　Research paper (other academic)

自然免疫の最近の進歩

審良 静男

2016/12　Research paper (other academic)

マクロファージ・単球サブセットとその役割

審良 静男

2016/12　Research paper (other academic)

Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation

Shigemiki Omiya, Yosuke Omori, Manabu Taneike, Andrea Protti, Osamu Yamaguchi, Shizuo Akira, Ajay M. Shah, Kazuhiko Nishida, Kinya Otsu

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 311　No. 6　p. H1485-H1497　2016/12　Research paper (scientific journal)

Genome-wide map of RNA degradation kinetics patterns in dendritic cells after LPS stimulation facilitates identification of primary sequence and secondary structure motifs in mRNAs

Yutaro Kumagai, Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Yutaka Suzuki

BMC GENOMICS　Vol. 17　No. Suppl 13　2016/12　Research paper (scientific journal)

Bone-protective Functions of Netrin 1 Protein.

Kenta Maruyama, Takahiko Kawasaki, Masahide Hamaguchi, Motomu Hashimoto, Moritoshi Furu, Hiromu Ito, Takao Fujii, Naoki Takemura, Thangaraj Karuppuchamy, Takeshi Kondo, Takumi Kawasaki, Masahiro Fukasaka, Takuma Misawa, Tatsuya Saitoh, Yutaka Suzuki, Mikaël M Martino, Yutaro Kumagai, Shizuo Akira

The Journal of biological chemistry　Vol. 291　No. 46　p. 23854-23868　2016/11/11　Research paper (scientific journal)

自然免疫と創薬の未来

審良 静男

2016/11　Research paper (other academic)

各種病態に関わるマクロファージ・サブセット

審良 静男

2016/11　Research paper (other academic)

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira

JOURNAL OF IMMUNOLOGY　Vol. 197　No. 7　p. 3749-3752　2016/10　Research paper (scientific journal)

Innate immunity and Inflammation

Shizuo Akira

2016/10　Research paper (other academic)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2016/10　Research paper (international conference proceedings)

Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product.

Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S

J Immunol.　Vol. 197　No. 7　p. 2563-2566　2016/10　Research paper (scientific journal)

TLR7 Structure: Cut in Z-Loop

Kazuhiko Maeda, Shizuo Akira

IMMUNITY　Vol. 45　No. 4　p. 705-707　2016/10　Research paper (scientific journal)

Functions of macrophage/monocyte subsets revealed by gene targeting

Shizuo Akira

2016/09　Research paper (international conference proceedings)

Innate Molecular Identification of a novel monocyte subset involved in lung fibrosis

S. Akira

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 46　p. 500-501　2016/08　Research paper (international conference proceedings)

免疫・炎症に関わるマクロファージ・単球サブセット

審良 静男

2016/07　Research paper (other academic)

マクロファージ・単球サブセットの同定と機能的役割

審良 静男

2016/07　Research paper (other academic)

Regulation of inflammasomes by autophagy

Tatsuya Saitoh, Shizuo Akira

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 138　No. 1　p. 28-36　2016/07　Research paper (scientific journal)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2016/06　Research paper (international conference proceedings)

Anti-viral responses mediated by ZAP-like receptors

Tatsuta Saitoh, Tatsuya Kozaki, Shizuo Akira

2016/06　Research paper (international conference proceedings)

Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency

Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta, Hiroshi Takayanagi

IMMUNITY　Vol. 44　No. 6　p. 1434-1443　2016/06　Research paper (scientific journal)

Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs

Diana Rose E. Ranoa, Akash D. Parekh, Sean P. Pitroda, Xiaona Huang, Thomas Darga, Anthony C. Wong, Lei Huang, Jorge Andrade, Jonathan P. Staley, Takashi Satoh, Shizuo Akira, Ralph R. Weichselbaum, Nikolai N. Khodarev

ONCOTARGET　Vol. 7　No. 18　p. 26496-26515　2016/05　Research paper (scientific journal)

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano, Kiyoshi Takeda

Nature　Vol. 532　No. 7597　p. 117-121　2016/04/07　Research paper (scientific journal)

マクロファージ・単球サブセットとその役割

審良 静男

2016/04　Research paper (other academic)

Functional diversity in macrophage/monocyte subsets.

Shizuo Akira

2016/04　Research paper (international conference proceedings)

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

Mikael M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Mueller, Shizuo Akira

NATURE COMMUNICATIONS　Vol. 7　2016/03　Research paper (scientific journal)

各種病態に関わるマクロファージ・単球サブセットの同定

審良 静男

2016/03　Research paper (other academic)

自然免疫と炎症

審良 静男

2016/03　Research paper (other academic)

Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

Mariko Yokogawa, Takashi Tsushima, Nobuo N. Noda, Hiroyuki Kumeta, Yoshiaki Enokizono, Kazuo Yamashita, Daron M. Standley, Osamu Takeuchi, Shizuo Akira, Fuyuhiko Inagaki

SCIENTIFIC REPORTS　Vol. 6　2016/03　Research paper (scientific journal)

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector

Sayaka Tsuzuki, Masashi Tachibana, Masahisa Hemmi, Tomoko Yamaguchi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Kenji Kawabata, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi

INTERNATIONAL IMMUNOLOGY　Vol. 28　No. 3　p. 105-115　2016/03　Research paper (scientific journal)

Functional diversity in macrophage/monocyte subsets.

Shizuo Akira

2016/02　Research paper (international conference proceedings)

PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine

Ting-Hin Ho, Chun Kew, Pak-Yin Lui, Chi-Ping Chan, Takashi Satoh, Shizuo Akira, Dong-Yan Jin, Kin-Hang Kok

JOURNAL OF VIROLOGY　Vol. 90　No. 3　p. 1557-1568　2016/02　Research paper (scientific journal)

LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation

Morimoto, K., Baba, Y., Shinohara, H., Kang, S., Nojima, S., Kimura, T., Ito, D., Yoshida, Y., Maeda, Y., Sarashina-Kida, H., Nishide, M., Hosokawa, T., Kato, Y., Hayama, Y., Kinehara, Y., Okuno, T., Takamatsu, H., Hirano, T., Shima, Y., Narazaki, M., Kurosaki, T., Toyofuku, T., Kumanogoh, A.

Sci Rep　Vol. 6　p. 25738-25738　2016　Research paper (scientific journal)

Toll-like receptor signaling and its inducible proteins

Takashi Satoh, Shizuo Akira

Microbiology Spectrum　Vol. 4　No. 6　2016　Research paper (scientific journal)

Impaired autophagy in macrophages promotes inflammatory eye disease

Andrea Santeford, Luke A. Wiley, Sunmin Park, Sonya Bamba, Rei Nakamura, Abdelaziz Gdoura, Thomas A. Ferguson, P. Kumar Rao, Jun-Lin Guan, Tatsuya Saitoh, Shizuo Akira, Ramnik Xavier, Herbert W. Virgin, Rajendra S. Apte

AUTOPHAGY　Vol. 12　No. 10　p. 1876-1885　2016　Research paper (scientific journal)

Raman spectroscopy as a tool for label-free lymphocyte cell line discrimination

Alison J. Hobro, Yutaro Kumagai, Shizuo Akira, Nicholas I. Smith

ANALYST　Vol. 141　No. 12　p. 3756-3764　2016　Research paper (scientific journal)

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

Sunmin Park, Michael D. Buck, Chandni Desai, Xin Zhang, Ekaterina Loginicheva, Jennifer Martinez, Michael L. Freeman, Tatsuya Saitoh, Shizuo Akira, Jun-Lin Guan, You-Wen He, Marcia A. Blackman, Scott A. Handley, Beth Levine, Douglas R. Green, Tiffany A. Reese, Maxim N. Artyomov, Herbert W. Virgin

CELL HOST & MICROBE　Vol. 19　No. 1　p. 91-101　2016/01　Research paper (scientific journal)

Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages

Pengyan Xia, Shuo Wang, Ying Du, Guanling Huang, Takashi Satoh, Shizuo Akira, Zusen Fan

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 212　No. 13　p. 2305-2321　2015/12　Research paper (scientific journal)

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

Harshad Ingle, Sushil Kumar, Ashwin Ashok Raut, Anamika Mishra, Diwakar Dattatraya Kulkarni, Takeshi Kameyama, Akinori Takaoka, Shizuo Akira, Himanshu Kumar

SCIENCE SIGNALING　Vol. 8　No. 406　2015/12　Research paper (scientific journal)

TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair

Yuji Ogura, Sajedah M. Hindi, Shuichi Sato, Guangyan Xiong, Shizuo Akira, Ashok Kumar

NATURE COMMUNICATIONS　Vol. 6　2015/12　Research paper (scientific journal)

Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model

Hiromi Matsuda, Kanako Hosono, Seri Tsuru, Chie Kurashige, Kazuki Sekiguchi, Shizuo Akira, Satoshi Uematsu, Hirotsugu Okamoto, Masataka Majima

LIFE SCIENCES　Vol. 142　p. 1-7　2015/12　Research paper (scientific journal)

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis

Masaki Inada, Morichika Takita, Satoshi Yokoyama, Kenta Watanabe, Tsukasa Tominari, Chiho Matsumoto, Michiko Hirata, Yoshiro Maru, Takayuki Maruyama, Yukihiko Sugimoto, Shuh Narumiya, Satoshi Uematsu, Shizuo Akira, Gillian Murphy, Hideaki Nagase, Chisato Miyaura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 50　p. 29781-29793　2015/12　Research paper (scientific journal)

P62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto

Cell Reports　Vol. 13　No. 2　p. 223-233　2015/10/13　Research paper (scientific journal)

免疫反応におけるmRNA制御

審良 静男

2015/10　Research paper (other academic)

Antiviral responses revealed by gene targeting

Shizuo Akira

2015/10　Research paper (international conference proceedings)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2015/09　Research paper (international conference proceedings)

Regnase-1, a ribonuclease essential to the inflammatory and immune responses

Shizuo Akira

2015/09　Research paper (international conference proceedings)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Takashi Kojima, Takahiro Yamada, Rina Akaishi, Itsuko Furuta, Tatsuya Saitoh, Kazuhiko Nakabayashi, Keiichi I. Nakayama, Keiko Nakayama, Shizuo Akira, Hisanori Minakami

REPRODUCTIVE BIOLOGY　Vol. 15　No. 3　p. 131-138　2015/09　Research paper (scientific journal)

Resveratrol inhibits the acetylated alpha-tubulin-mediated assembly of the NLRP3-inflammasome

Takuma Misawa, Tatsuya Saitoh, Tatsuya Kozaki, Sehoon Park, Michihiro Takahama, Shizuo Akira

INTERNATIONAL IMMUNOLOGY　Vol. 27　No. 9　p. 425-434　2015/09　Research paper (scientific journal)

Emerging molecules in the interface between skeletal system and innate immunity

Kenta Maruyama, Shizuo Akira

PHARMACOLOGICAL RESEARCH　Vol. 99　p. 223-228　2015/09　Research paper (scientific journal)

MTOR complex signaling through the SEMA4A-plexin B2 axis is required for optimal activation and differentiation of CD8<sup>+</sup> T cells

Daisuke Ito, Satoshi Nojima, Masayuki Nishide, Tatsusada Okuno, Hyota Takamatsu, Sujin Kang, Tetsuya Kimura, Yuji Yoshida, Keiko Morimoto, Yohei Maeda, Takashi Hosokawa, Toshihiko Toyofuku, Jun Ohshima, Daisuke Kamimura, Masahiro Yamamoto, Masaaki Murakami, Eiichi Morii, Hiromi Rakugi, Yoshitaka Isaka, Atsushi Kumanogoh

Journal of Immunology　Vol. 195　No. 3　p. 934-943　2015/08/01　Research paper (scientific journal)

Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production

Adriana Flores-Langarica, Saeeda Bobat, Jennifer L. Marshall, Juan Carlos Yam-Puc, Charlotte N. Cook, Karine Serre, Robert A. Kingsley, Leopoldo Flores-Romo, Satoshi Uematsu, Shizuo Akira, Ian R. Henderson, Kai M. Toellner, Adam F. Cunningham

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 45　No. 8　p. 2299-2311　2015/08　Research paper (scientific journal)

Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation

Eriko Sumiya, Takako Negishi-Koga, Yusuke Nagai, Ayako Suematsu, Tomomi Suda, Masahiro Shinohara, Kojiro Sato, Hideki Sanjo, Shizuo Akira, Hiroshi Takayanagi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 463　No. 4　p. 1284-1290　2015/08　Research paper (scientific journal)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Honami Toyonaga, Chiharu Yamaguchi, Ayumi Hasegawa, Takeshi Nakahara, Junichi Hachisuka, Shizuo Akira, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

NATURE MEDICINE　Vol. 21　No. 8　p. 927-931　2015/08　Research paper (scientific journal)

Role of zinc-finger anti-viral protein in host defense against Sindbis virus

Tatsuya Kozaki, Michihiro Takahama, Takuma Misawa, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh

INTERNATIONAL IMMUNOLOGY　Vol. 27　No. 7　p. 357-364　2015/07　Research paper (scientific journal)

Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy

Yuya Asahina, Shinobu Komiya, Ami Ohagi, Rina Fujimoto, Hiroko Tamagaki, Katsuhiro Nakagawa, Takashi Sato, Shizuo Akira, Toshifumi Takao, Akira Ishii, Yoshiaki Nakahara, Hironobu Hojo

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　Vol. 54　No. 28　p. 8226-8230　2015/07　Research paper (scientific journal)

Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCR alpha beta(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis

Hideki Sanjo, Shigeo Tokumaru, Shizuo Akira, Shinsuke Taki

PLOS ONE　Vol. 10　No. 7　2015/07　Research paper (scientific journal)

Regnase-1, a ribonuclease involved in the inflammatory and immune responses

Shizuo Akira

2015/07　Research paper (international conference proceedings)

Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications.

Yuji Yoshida, Atsushi Ogata, Sujin Kang, Kousuke Ebina, Kenrin Shi, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Keiko Morimoto, Masayuki Nishide, Takashi Hosokawa, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Hideki Tsuboi, Yukihiko Saeki, Tetsuya Tomita, Toshio Tanaka, Atsushi Kumanogoh

Arthritis & rheumatology (Hoboken, N.J.)　Vol. 67　No. 6　p. 1481-90　2015/06

The role of Regnase-1 in the immune response

Shizuo Akira

2015/06　Research paper (international conference proceedings)

Functional diversity of macrophage/monocyte subsets

Shizuo Akira

2015/06　Research paper (international conference proceedings)

Role of interleukin-33 during Schistosoma mansoni infection

Yombo Kalenda, Kyoko Masuda, Eman Sayed, Risa Nakamura, Kentaro Kato, Satoshi Uematsu, Shizuo Akira, Shinjiro Hamano

JOURNAL OF IMMUNOLOGY　Vol. 194　2015/05　Research paper (scientific journal)

Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

Michelle Goritzka, Spyridon Makris, Fahima Kausar, Lydia R. Durant, Catherine Pereira, Yutaro Kumagai, Fiona J. Culley, Matthias Mack, Shizuo Akira, Cecilia Johansson

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 212　No. 5　p. 699-714　2015/05　Research paper (scientific journal)

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity

S. Kumar, H. Ingle, S. Mishra, R. S. Mahla, A. Kumar, T. Kawai, S. Akira, A. Takaoka, A. A. Raut, H. Kumar

CELL DEATH & DISEASE　Vol. 6　2015/05　Research paper (scientific journal)

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

Masahiro Fukasaka, Daisuke Asari, Eiji Kiyotoh, Arimichi Okazaki, Yasuyuki Gomi, Takeshi Tanimoto, Osamu Takeuchi, Shizuo Akira, Mitsuhiko Hori

PLOS ONE　Vol. 10　No. 5　2015/05　Research paper (scientific journal)

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi

CELL　Vol. 161　No. 5　p. 1058-1073　2015/05　Research paper (scientific journal)

Regnase-1, a ribonuclease involved in the inflammatory and immune responses

Shizuo Akira

2015/05　Research paper (international conference proceedings)

Regnase-1: a ribonuclease involved in innate and adaptive immunity

Shizuo Akira

2015/05　Research paper (international conference proceedings)

Glucocorticoid augments lipopolysaccharide-induced activation of the I kappa B zeta-dependent genes encoding the anti-microbial glycoproteins lipocalin 2 and pentraxin 3

Soh Yamazaki, Shizuo Akira, Hideki Sumimoto

JOURNAL OF BIOCHEMISTRY　Vol. 157　No. 5　p. 399-410　2015/05　Research paper (scientific journal)

Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice (vol 161, pg 4652, 1998)

K. Takeda, T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, S. Akira

JOURNAL OF IMMUNOLOGY　Vol. 194　No. 7　p. 3526-3526　2015/04　Research paper (scientific journal)

Toll-like receptors.

Takeda K, Akira S

Curr Protoc Immunol　Vol. 109　p. 14.12.1-14.12.10　2015/04　Research paper (scientific journal)

Control of the inflammatory and immune responses by the ribonuclease, Regnase-1

Shizuo Akira

2015/04　Research paper (international conference proceedings)

5-Azacytidine-induced Protein 2 (AZI2) Regulates Bone Mass by Fine-tuning Osteoclast Survival

Kenta Maruyama, Masahiro Fukasaka, Satoshi Uematsu, Osamu Takeuchi, Takeshi Kondo, Tatsuya Saitoh, Mikael M. Martino, Shizuo Akira

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 15　p. 9377-9386　2015/04　Research paper (scientific journal)

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Taito Matsuda, Naoya Murao, Yuki Katano, Berry Juliandi, Jun Kohyama, Shizuo Akira, Taro Kawai, Kinichi Nakashima

NATURE COMMUNICATIONS　Vol. 6　2015/03　Research paper (scientific journal)

自然免疫と炎症

Shizuo Akira

2015/03　Research paper (other academic)

自然免疫の最近の進歩

Shizuo Akira

2015/03　Research paper (other academic)

Rapid CD4(+) T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9

Shaikh M. Atif, Seung-Joo Lee, Lin-Xi Li, Satoshi Uematsu, Shizuo Akira, Sara Gorjestani, Xin Lin, Edina Schweighoffer, Victor L. J. Tybulewicz, Stephen J. McSorley

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 45　No. 2　p. 513-524　2015/02　Research paper (scientific journal)

Regnase-1, a ribonuclease involved in the control of immune responses

Shizuo Akira

2015/01　Research paper (international conference proceedings)

Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B

Yuichi Kitai, Osamu Takeuchi, Takumi Kawasaki, Daisuke Ori, Takuya Sueyoshi, Motoya Murase, Shizuo Akira, Taro Kawai

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 290　No. 2　p. 1269-1280　2015/01　Research paper (scientific journal)

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

Meghana N. Patel, William G. Bernard, Nikolay B. Milev, William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Sam Virtue, Krisztina Hegyi, Stephanie Bonnafous, Beatrice Bailly-Maitre, Yajing Chu, Julian L. Griffin, Ziad Mallat, Robert V. Considine, Albert Tran, Philippe Gual, Osamu Takeuchi, Shizuo Akira, Antonio Vidal-Puig, Martin R. Bennett, Jaswinder K. Sethi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 112　No. 2　p. 506-511　2015/01　Research paper (scientific journal)

Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors

Surya Pandey, Taro Kawai, Shizuo Akira

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY　Vol. 7　No. 1　2015/01　Research paper (scientific journal)

Regnase-1;a ribonuclease that controls the immune reaction

Shizuo Akira

2014/11　Research paper (international conference proceedings)

RAB2Bは細胞質内二本鎖DNAによって誘導される抗ウイルス応答を制御する

Shizuo Akira, Tatsuya Saitoh

2014/11

JAK2V617F(+) myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2

Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Shunya Arai, Takashi Satoh, Shizuo Akira, Mineo Kurokawa

BLOOD　Vol. 124　No. 19　p. 2996-3006　2014/11　Research paper (scientific journal)

B Cell-Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers

Chetna Soni, Eric B. Wong, Phillip P. Domeier, Tahsin N. Khan, Takashi Satoh, Shizuo Akira, Ziaur S. M. Rahman

JOURNAL OF IMMUNOLOGY　Vol. 193　No. 9　p. 4400-4414　2014/11　Research paper (scientific journal)

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Xuanming Shi, Zilai Zhang, Xiaoming Zhan, Mou Cao, Takashi Satoh, Shizuo Akira, Karl Shpargel, Terry Magnuson, Qingtian Li, Rongfu Wang, Chaochen Wang, Kai Ge, Jiang Wu

NATURE COMMUNICATIONS　Vol. 5　2014/11　Research paper (scientific journal)

Regnase-1, an endoribonuclease involvled in the immune response

Shizuo Akira

2014/10　Research paper (international conference proceedings)

Elucidation of anti-viral responses by reverse genetics

Shizuo Akira

2014/10　Research paper (international conference proceedings)

オルガネラ傷害に起因するNLRP3インフラマソーム活性化メカニズムの解明

Shizuo Akira, Takuma Misawa, Tatsuya Saitoh

2014/10　Research paper (other academic)

Akirin2 is critical for inducing inflammatory genes by bridging I kappa B-zeta and the SWI/SNF complex

Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M. Standley, Jules A. Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi

EMBO JOURNAL　Vol. 33　No. 20　p. 2332-2348　2014/10　Research paper (scientific journal)

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

Panagiotis Ntziachristos, Aristotelis Tsirigos, G. Grant Welstead, Thomas Trimarchi, Sofia Bakogianni, Luyao Xu, Evangelia Loizou, Linda Holmfeldt, Alexandros Strikoudis, Bryan King, Jasper Mullenders, Jared Becksfort, Jelena Nedjic, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Giovanni Tonon, Takashi Satoh, Laurens Kruidenier, Rab Prinjha, Shizuo Akira, Pieter Van Vlierberghe, Adolfo A. Ferrando, Rudolf Jaenisch, Charles G. Mullighan, Iannis Aifantis

NATURE　Vol. 514　No. 7523　p. 513-+　2014/10　Research paper (scientific journal)

TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression

Silvia Stockinger, Claudia U. Duerr, Marcus Fulde, Tamas Dolowschiak, Johanna Pott, Ines Yang, Daniel Eibach, Fredrik Backhed, Shizuo Akira, Sebastian Suerbaum, Martijn Brugman, Mathias W. Hornef

JOURNAL OF IMMUNOLOGY　Vol. 193　No. 8　p. 4223-4234　2014/10　Research paper (scientific journal)

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux

Luigi Franchi, Tatjana Eigenbrod, Raul Munoz-Planillo, Ulas Ozkurede, Yun-Gi Kim, Arindam Chakrabarti, Michael Gale, Robert H. Silverman, Marco Colonna, Shizuo Akira, Gabriel Nunez

JOURNAL OF IMMUNOLOGY　Vol. 193　No. 8　p. 4214-4222　2014/10　Research paper (scientific journal)

Regnase-1, a ribonuclease essential to the inflammatory and immune responses

Shizuo Akira

2014/09　Research paper (other academic)

MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus

Lisa A. Reynolds, Yvonne Harcus, Katherine A. Smith, Lauren M. Webb, James P. Hewitson, Ewan A. Ross, Sheila Brown, Satoshi Uematsu, Shizuo Akira, David Gray, Mohini Gray, Andrew S. MacDonald, Adam F. Cunningham, Rick M. Maizels

JOURNAL OF IMMUNOLOGY　Vol. 193　No. 6　p. 2984-2993　2014/09　Research paper (scientific journal)

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Yoshiyuki Goto, Takashi Obata, Jun Kunisawa, Shintaro Sato, Ivaylo I. Ivanov, Aayam Lamichhane, Natsumi Takeyama, Mariko Kamioka, Mitsuo Sakamoto, Takahiro Matsuki, Hiromi Setoyama, Akemi Imaoka, Satoshi Uematsu, Shizuo Akira, Steven E. Domino, Paulina Kulig, Burkhard Becher, Jean-Christophe Renauld, Chihiro Sasakawa, Yoshinori Umesaki, Yoshimi Benno, Hiroshi Kiyono

SCIENCE　Vol. 345　No. 6202　p. 1310-+　2014/09　Research paper (scientific journal)

Tribbles Homo log 3 Attenuates Mammalian Target of Rapamycin Complex-2 Signaling and Inflammation in the Diabetic Kidney

Emily Borsting, Shalin V. Patel, Anne-Emilie Decleves, Sarah J. Lee, Qazi M. Rahman, Shizuo Akira, Joe Satriano, Kumar Sharma, Volker Vallon, Robyn Cunard

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY　Vol. 25　No. 9　p. 2067-2078　2014/09　Research paper (scientific journal)

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

Sayaka Inokuchi-Shimizu, Eek Joong Park, Yoon Seok Roh, Ling Yang, Bi Zhang, Jingyi Song, Shuang Liang, Michael Pimienta, Koji Taniguchi, Xuefeng Wu, Kinji Asahina, William Lagakos, Mason R. Mackey, Shizuo Akira, Mark H. Ellisman, Dorothy D. Sears, Jerrold M. Olefsky, Michael Karin, David A. Brenner, Ekihiro Seki

Journal of Clinical Investigation　Vol. 124　No. 8　p. 3566-3578　2014/08/01　Research paper (scientific journal)

Regnase-1, a ribonuclease involved in the control of immune responses

Shizuo Akira

2014/07　Research paper (international conference proceedings)

Principles of innate immunity

Tsuneyasu Kaisho, Shizuo Akira

Rheumatology: Sixth Edition　Vol. 1-2　p. 127-133　2014/06/19　Part of collection (book)

Epicutaneously applied Der p 2 induces a strong T(H)2-biased antibody response in C57BL/6 mice, independent of functional TLR4

C. Stremnitzer, K. Manzano-Szalai, P. Starkl, A. Willensdorfer, S. Schrom, J. Singer, U. Reichart, S. Akira, E. Jensen-Jarolim

ALLERGY　Vol. 69　No. 6　p. 741-751　2014/06　Research paper (scientific journal)

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

Jayoung Choi, Sunmin Park, Scott B. Biering, Elizabeth Selleck, Catherine Y. Liu, Xin Zhang, Naonobu Fujita, Tatsuya Saitoh, Shizuo Akira, Tamotsu Yoshimori, L. David Sibley, Seungmin Hwang, Herbert W. Virgin

IMMUNITY　Vol. 40　No. 6　p. 924-935　2014/06　Research paper (scientific journal)

自然免疫と炎症

Shizuo Akira

2014/06　Research paper (other academic)

Regnase-1, an endoribonuclease regulating the immune response

Shizuo Akira

2014/06　Research paper (international conference proceedings)

微小管によるミトコンドリアの空間配置転換はNLRP3インフラマソームを活性化する

Takuma Misawa

2014/06　Research paper (other academic)

Regnase-1, a ribonuclease involved in the control of immune responses

Shizuo Akira

2014/06　Research paper (international conference proceedings)

自然免疫の最近の進歩

Shizuo Akira

2014/06　Research paper (other academic)

Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.

Hong Zhao, Taiki Aoshi, Satoru Kawai, Yuki Mori, Aki Konishi, Muge Ozkan, Yukiko Fujita, Yasunari Haseda, Mikiko Shimizu, Masako Kohyama, Kouji Kobiyama, Kei Eto, Junichi Nabekura, Toshihiro Horii, Tomoko Ishino, Masao Yuda, Hiroaki Hemmi, Tsuneyasu Kaisho, Shizuo Akira, Manabu Kinoshita, Koujiro Tohyama, Yoshichika Yoshioka, Ken J Ishii, Cevayir Coban

Cell host & microbe　Vol. 15　No. 5　p. 551-63　2014/05/14　Research paper (scientific journal)

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-kappa B Activation

Hisaaki Shinohara, Marcelo Behar, Kentaro Inoue, Michio Hiroshima, Tomoharu Yasuda, Takeshi Nagashima, Shuhei Kimura, Hideki Sanjo, Shiori Maeda, Noriko Yumoto, Sewon Ki, Shizuo Akira, Yasushi Sako, Alexander Hoffmann, Tomohiro Kurosaki, Mariko Okada-Hatakeyama

SCIENCE　Vol. 344　No. 6185　p. 760-764　2014/05　Research paper (scientific journal)

Prospective signs of cleidocranial dysplasia in Cebpb deficiency

Boyen Huang, Katsu Takahashi, Ernest A. Jennings, Pongthorn Pumtang-on, Honoka Kiso, Yumiko Togo, Kazuyuki Saito, Manabu Sugai, Shizuo Akira, Akira Shimizu, Kazuhisa Bessho

JOURNAL OF BIOMEDICAL SCIENCE　Vol. 21　No. 1　2014/05　Research paper (scientific journal)

自然免疫の最近の進歩

Shizuo Akira

2014/05　Research paper (other academic)

Regnase-1-mediated regulation of the immune response

Shizuo Akira

2014/05　Research paper (international conference proceedings)

Regnase-1, a ribonuclease essential for the control of immune responses

Shizuo Akira

2014/05　Research paper (international conference proceedings)

Intrinsic Disorder Mediates Cooperative Signal Transduction in STIM1

Yukio Furukawa, Shunsuke Teraguchi, Takahisa Ikegami, Onur Dagliyan, Lin Jin, Damien Hall, Nikolay V. Dokholyan, Keiichi Namba, Shizuo Akira, Tomohiro Kurosaki, Yoshihiro Baba, Daron M. Standley

JOURNAL OF MOLECULAR BIOLOGY　Vol. 426　No. 10　p. 2082-2097　2014/05　Research paper (scientific journal)

Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii

Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira, Masahiro Yamamoto

Journal of Immunology　Vol. 192　No. 7　p. 3328-3335　2014/04/01　Research paper (scientific journal)

Generation of colonic IgA-secreting cells in the caecal patch.

Kazunori Masahata, Eiji Umemoto, Hisako Kayama, Manato Kotani, Shota Nakamura, Takashi Kurakawa, Junichi Kikuta, Kazuyoshi Gotoh, Daisuke Motooka, Shintaro Sato, Tomonori Higuchi, Yoshihiro Baba, Tomohiro Kurosaki, Makoto Kinoshita, Yosuke Shimada, Taishi Kimura, Ryu Okumura, Akira Takeda, Masaru Tajima, Osamu Yoshie, Masahiro Fukuzawa, Hiroshi Kiyono, Sidonia Fagarasan, Tetsuya Iida, Masaru Ishii, Kiyoshi Takeda

Nature communications　Vol. 5　p. 3704-3704　2014/04　Research paper (scientific journal)

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira, Taro Kawai

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 15　p. 5646-5651　2014/04　Research paper (scientific journal)

Nucleic acid sensing by T cells initiates Th2 cell differentiation

Takayuki Imanishi, Chitose Ishihara, Mohamed El Sherif Gadelhaq Badr, Akiko Hashimoto-Tane, Yayoi Kimura, Taro Kawai, Osamu Takeuchi, Ken J. Ishii, Shun'ichiro Taniguchi, Tetsuo Noda, Hisashi Hirano, Frank Brombacher, Glen N. Barber, Shizuo Akira, Takashi Saito

NATURE COMMUNICATIONS　Vol. 5　2014/04　Research paper (scientific journal)

The Enzyme Cyp26b1 Mediates Inhibition of Mast Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis

Yosuke Kurashima, Takeaki Amiya, Kumiko Fujisawa, Naoko Shibata, Yuji Suzuki, Yuta Kogure, Eri Hashimoto, Atsushi Otsuka, Kenji Kabashima, Shintaro Sato, Takeshi Sato, Masato Kubo, Shizuo Akira, Kensuke Miyake, Jun Kunisawa, Hiroshi Kiyono

IMMUNITY　Vol. 40　No. 4　p. 530-541　2014/04　Research paper (scientific journal)

Regnase-1, a ribonuclease involved in the immune regulation

Shizuo Akira

2014/04　Research paper (international conference proceedings)

RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma

Adeline R. Lam, Nina Le Bert, Samantha S. W. Ho, Yu J. Shen, Melissa L. F. Tang, Gordon M. Xiong, J. Ludovic Croxford, Christine X. Koo, Ken J. Ishii, Shizuo Akira, David H. Raulet, Stephan Gasser

CANCER RESEARCH　Vol. 74　No. 8　p. 2193-2203　2014/04　Research paper (scientific journal)

Humoral Immunity and CD4(+) Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis

Marie-Alice Vitry, Delphine Hanot Mambres, Carl De Trez, Shizuo Akira, Bernhard Ryffel, Jean-Jacques Letesson, Eric Muraille

JOURNAL OF IMMUNOLOGY　Vol. 192　No. 8　p. 3740-3752　2014/04　Research paper (scientific journal)

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

Naoki Takemura, Takumi Kawasaki, Jun Kunisawa, Shintaro Sato, Aayam Lamichhane, Kouji Kobiyama, Taiki Aoshi, Junichi Ito, Kenji Mizuguchi, Thangaraj Karuppuchamy, Kouta Matsunaga, Shoichiro Miyatake, Nobuko Mori, Tohru Tsujimura, Takashi Satoh, Yutaro Kumagai, Taro Kawai, Daron M. Standley, Ken J. Ishii, Hiroshi Kiyono, Shizuo Akira, Satoshi Uematsu

Nature Communications　Vol. 5　2014/03/18　Research paper (scientific journal)

TRIF Signaling Is Essential for TLR4-Driven IgE Class Switching

Erin Janssen, Esra Ozcan, Kyriaki Liadaki, Haifa H. Jabara, John Manis, Sumana Ullas, Shizuo Akira, Katherine A. Fitzgerald, Douglas T. Golenbock, Raif S. Geha

JOURNAL OF IMMUNOLOGY　Vol. 192　No. 6　p. 2651-2658　2014/03　Research paper (scientific journal)

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice

Christine Koulis, Yung-Chih Chen, Christian Hausding, Ingo Ahrens, Tin Soe Kyaw, Christopher Tay, Terri Allen, Karin Jandeleit-Dahm, Matthew J. Sweet, Shizuo Akira, Alexander Bobik, Karlheinz Peter, Alex Agrotis

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 34　No. 3　p. 516-525　2014/03　Research paper (scientific journal)

RIG-I Detects mRNA of Intracellular Salmonella enterica Serovar Typhimurium during Bacterial Infection

Mirco Schmolke, Jenish R. Patel, Elisa de Castro, Maria T. Sanchez-Aparicio, Melissa B. Uccellini, Jennifer C. Miller, Balaji Manicassamy, Takashi Satoh, Taro Kawai, Shizuo Akira, Miriam Merad, Adolfo Garcia-Sastre

MBIO　Vol. 5　No. 2　p. e01006-e01014　2014/03　Research paper (scientific journal)

Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

Kouji Kobiyama, Taiki Aoshi, Hirotaka Narita, Etsushi Kuroda, Masayuki Hayashi, Kohhei Tetsutani, Shohei Koyama, Shinichi Mochizuki, Kazuo Sakurai, Yuko Katakai, Yasuhiro Yasutomi, Shinobu Saijo, Yoichiro Iwakura, Shizuo Akira, Cevayir Coban, Ken J. Ishii

Proceedings of the National Academy of Sciences of the United States of America　Vol. 111　No. 8　p. 3086-3091　2014/02/25　Research paper (scientific journal)

Prevention of Intestinal Allergy in Mice by rflaA: Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC

Stefan Schuelke, Sonja Wolfheimer, Gabriele Gadermaier, Andrea Wangorsch, Susanne Siebeneicher, Peter Briza, Ingo Spreitzer, Dirk Schiller, Bettina Loeschner, Satoshi Uematsu, Bernard Ryffel, Shizuo Akira, Zoe Waibler, Stefan Vieths, Masako Toda, Stephan Scheurer

PLOS ONE　Vol. 9　No. 2　2014/02　Research paper (scientific journal)

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J. Ishii, Shizuo Akira, Toru Okamoto, Yoshiharu Matsuura

Journal of Virology　Vol. 88　No. 4　p. 2157-2167　2014/02　Research paper (scientific journal)

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

J. A. Wali, D. Rondas, M. D. McKenzie, Y. Zhao, L. Elkerbout, S. Fynch, E. N. Gurzov, S. Akira, C. Mathieu, T. W.H. Kay, L. Overbergh, A. Strasser, H. E. Thomas

Cell Death and Disease　Vol. 5　No. 3　2014　Research paper (scientific journal)

CD103-CD11b+dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin

S. M. Atif, S. Uematsu, S. Akira, S. J. McSorley

MUCOSAL IMMUNOLOGY　Vol. 7　No. 1　p. 68-77　2014/01　Research paper (scientific journal)

Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice

Y. H. Connie Leung, John M. Nicholls, Chuk Kwan Ho, Sin Fun Sia, Chris K. P. Mok, Sophie A. Valkenburg, Peter Cheung, Kenrie P. Y. Hui, Renee W. Y. Chan, Y. Guan, S. Akira, J. S. Malik Peiris

Journal of General Virology　Vol. 95　No. 9　p. 1870-1879　2014　Research paper (scientific journal)

The Early Activation of CD8(+) T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

Masahisa Hemmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Kenji Kawabata, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi

BIOMED RESEARCH INTERNATIONAL　Vol. 2014　No. Pathology　2014　Research paper (scientific journal)

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Khushbu K. Patel, Hiroyuki Miyoshi, Wandy L. Beatty, Richard D. Head, Nicole P. Malvin, Ken Cadwell, Jun-Lin Guan, Tatsuya Saitoh, Shizuo Akira, Per O. Seglen, Mary C. Dinauer, Herbert W. Virgin, Thaddeus S. Stappenbeck

EMBO Journal　Vol. 32　No. 24　p. 3130-3144　2013/12/11　Research paper (scientific journal)

Prostaglandin E-2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

Kazunari Sugita, Atsuko Ikenouchi-Sugita, Yasuko Nakayama, Haruna Yoshioka, Takashi Nomura, Jun-ichi Sakabe, Kyoko Nakahigashi, Etsushi Kuroda, Satoshi Uematsu, Jun Nakamura, Shizuo Akira, Motonobu Nakamura, Shuh Narumiya, Yoshiki Miyachi, Yoshiki Tokura, Kenji Kabashima

SCIENTIFIC REPORTS　Vol. 3　2013/10　Research paper (scientific journal)

Autophagy in infection, inflammation and immunity

Vojo Deretic, Tatsuya Saitoh, Shizuo Akira

Nature Reviews Immunology　Vol. 13　No. 10　p. 722-737　2013/10

The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation

Jianhui Ma, Bo Ram Bang, Jiawei Lu, So Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang

Science Signaling　Vol. 6　No. 295　2013/10/01　Research paper (scientific journal)

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant.

Nyström S, Bråve A, Falkeborn T, Devito C, Rissiek B, Johansson DX, Schröder U, Uematsu S, Akira S, Hinkula J, Applequist SE

Vaccines　Vol. 1　No. 4　p. 415-443　2013/09

Macrophages control innate inflammation

S. Akira, T. Misawa, T. Satoh, T. Saitoh

Diabetes, Obesity and Metabolism　Vol. 15　No. 3　p. 10-18　2013/09

Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model

Chung Truong Nguyen, Seol Hee Hong, Jeong-Im Sin, Hong Van Dinh Vu, Kwangjoon Jeong, Kyoung Oh Cho, Satoshi Uematsu, Shizuo Akira, Shee Eun Lee, Joon Haeng Rhee

Vaccine　Vol. 31　No. 37　p. 3879-3887　2013/08/20　Research paper (scientific journal)

The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling

Takumi Kawasaki, Naoki Takemura, Daron M. Standley, Shizuo Akira, Taro Kawai

Cell Host and Microbe　Vol. 14　No. 2　p. 148-158　2013/08/14　Research paper (scientific journal)

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

Ikuko Maejima, Atsushi Takahashi, Hiroko Omori, Tomonori Kimura, Yoshitsugu Takabatake, Tatsuya Saitoh, Akitsugu Yamamoto, Maho Hamasaki, Takeshi Noda, Yoshitaka Isaka, Tamotsu Yoshimori

EMBO JOURNAL　Vol. 32　No. 17　p. 2336-2347　2013/08　Research paper (scientific journal)

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus

Hanna Lee, Jun Komano, Yasunori Saitoh, Shoji Yamaoka, Tatsuya Kozaki, Takuma Misawa, Michihiro Takahama, Takashi Satoh, Osamu Takeuchi, Naoki Yamamoto, Yoshiharu Matsuurag, Tatsuya Saitoh, Shizuo Akira

Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 30　p. 12379-12384　2013/07/23　Research paper (scientific journal)

Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus

Jae Hee Lee, Tae Hoon Kim, Seo Jin Oh, Jung-Yoon Yoo, Shizuo Akira, Bon Jeong Ku, John P. Lydon, Jae-Wook Jeong

FASEB Journal　Vol. 27　No. 7　p. 2553-2563　2013/07　Research paper (scientific journal)

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.

Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T, Akira S

Proc Natl Acad Sci U S A　Vol. 110　No. 30　p. 12379-12384　2013/07　Research paper (scientific journal)

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis

Anna M. Lundberg, Daniel F. J. Ketelhuth, Maria E. Johansson, Norbert Gerdes, Sang Liu, Masahiro Yamamoto, Shizuo Akira, Goran K. Hansson

CARDIOVASCULAR RESEARCH　Vol. 99　No. 2　p. 364-373　2013/07　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

Yoshiharu Akitake, Yoshihito Nakatani, Daisuke Kamei, Masato Hosokawa, Hiroyasu Akatsu, Satoshi Uematsu, Shizuo Akira, Ichiro Kudo, Shuntaro Hara, Mitsuo Takahashi

Journal of Neuroscience Research　Vol. 91　No. 7　p. 909-919　2013/07　Research paper (scientific journal)

Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

Tadaomi Kawashima, Akemi Kosaka, Huimin Yan, Zijin Guo, Ryosuke Uchiyama, Ryutaro Fukui, Daisuke Kaneko, Yutaro Kumagai, Dong Ju You, Joaquim Carreras, Satoshi Uematsu, Myoung Ho Jang, Osamu Takeuchi, Tsuneyasu Kaisho, Shizuo Akira, Kensuke Miyake, Hiroko Tsutsui, Takashi Saito, Ikuko Nishimura, Noriko M. Tsuji

Immunity　Vol. 38　No. 6　p. 1187-1197　2013/06/27　Research paper (scientific journal)

Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance

Nagatoshi Fujiwara, Steven A. Porcelli, Takashi Naka, Ikuya Yano, Shinji Maeda, Hirotaka Kuwata, Shizuo Akira, Satoshi Uematsu, Takemasa Takii, Hisashi Ogura, Kazuo Kobayashi

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS　Vol. 1831　No. 6　p. 1177-1184　2013/06　Research paper (scientific journal)

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi

Journal of Immunology　Vol. 190　No. 11　p. 5702-5711　2013/06/01　Research paper (scientific journal)

XMalt1-induced cleavage of regnase-1 in CD4⁺ helper T cells regulates immune activation

Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M. Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira

Cell　Vol. 153　No. 5　p. 1036-1049　2013/05/23　Research paper (scientific journal)

Intestinal Lin(-)c-Kit(+)NKp46(-)CD4(-) Population Strongly Produces IL-22 upon IL-1 beta Stimulation

Youngae Lee, Yutaro Kumagai, Min Seong Jang, Jung-Hwan Kim, Bo-Gie Yang, Eun-Jung Lee, You-Me Kim, Shizuo Akira, Myoung Ho Jang

JOURNAL OF IMMUNOLOGY　Vol. 190　No. 10　p. 5296-5305　2013/05　Research paper (scientific journal)

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice

Gerard E. Kaiko, Zhixuan Loh, Kirsten Spann, Jason P. Lynch, Amit Lalwani, Zhenglong Zheng, Sophia Davidson, Satoshi Uematsu, Shizuo Akira, John Hayball, Kerrilyn R. Diener, Katherine J. Baines, Jodie L. Simpson, Paul S. Foster, Simon Phipps

Journal of Allergy and Clinical Immunology　Vol. 131　No. 5　p. 1331-e10　2013/05　Research paper (scientific journal)

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Hanna Lee, Jian Zou, Tatsuya Saitoh, Shizuo Akira

Nature Immunology　Vol. 14　No. 5　p. 454-460　2013/05　Research paper (scientific journal)

Poly ic triggers a cathepsin d- and ips-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis

Jian Zou, Taro Kawai, Tetsuo Tsuchida, Tatsuya Kozaki, Hiroki Tanaka, Kyung-Sue Shin, Himanshu Kumar, Shizuo Akira

Immunity　Vol. 38　No. 4　p. 717-728　2013/04/18　Research paper (scientific journal)

IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation

Hilary Sandig, Catherine E. Jobbings, Nestor Gonzalez Roldan, Jayde K. Whittingham-Dowd, Zane Orinska, Osamu Takeuchi, Shizuo Akira, Silvia Bulfone-Paus

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 43　No. 4　p. 979-988　2013/04　Research paper (scientific journal)

Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs

Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi

Journal of Immunology　Vol. 190　No. 8　p. 4037-4045　2013/04　Research paper (scientific journal)

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi, Shizuo Akira

Nature　Vol. 495　No. 7442　p. 524-528　2013/03/28　Research paper (scientific journal)

Enhanced Apoptosis by Disruption of the STAT3-IκB-ζ Signaling Pathway in Epithelial Cells Induces Sjögren's Syndrome-like Autoimmune Disease

Atsushi Okuma, Katsuaki Hoshino, Tomoyuki Ohba, Sawako Fukushi, Setsuya Aiba, Shizuo Akira, Masao Ono, Tsuneyasu Kaisho, Tatsushi Muta

Immunity　Vol. 38　No. 3　p. 450-460　2013/03/21　Research paper (scientific journal)

The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant

Choon Kit Tang, Taiki Aoshi, Nao Jounai, Junichi Ito, Keiichi Ohata, Kouji Kobiyama, Benoit H. Dessailly, Etsushi Kuroda, Shizuo Akira, Kenji Mizuguchi, Cevayir Coban, Ken J. Ishii

PLoS ONE　Vol. 8　No. 3　2013/03/21　Research paper (scientific journal)

Phenotypes of CCAAT/enhancer-binding protein beta deficiency: Hyperdontia and elongated coronoid process

B. Huang, K. Takahashi, T. Sakata-Goto, H. Kiso, Y. Togo, K. Saito, H. Tsukamoto, M. Sugai, S. Akira, A. Shimizu, K. Bessho

Oral Diseases　Vol. 19　No. 2　p. 144-150　2013/03　Research paper (scientific journal)

Commensal microbiota drive proliferation of conventional and Foxp3(+) regulatory CD4(+) T cells in mesenteric lymph nodes and Peyer's patches.

Cording S, Fleissner D, Heimesaat MM, Bereswill S, Loddenkemper C, Uematsu S, Akira S, Hamann A, Huehn J

European journal of microbiology & immunology　Vol. 3　No. 1　p. 1-10　2013/03

FIP200 regulates targeting of Atg16L1 to the isolation membrane

Taki Nishimura, Takeshi Kaizuka, Ken Cadwell, Mayurbhai H. Sahani, Tatsuya Saitoh, Shizuo Akira, Herbert W. Virgin, Noboru Mizushima

EMBO Reports　Vol. 14　No. 3　p. 284-291　2013/03　Research paper (scientific journal)

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

Takeshi Kondo, Junya Kobayashi, Tatsuya Saitoh, Kenta Maruyama, Ken J Ishii, Glen N Barber, Kenshi Komatsu, Shizuo Akira, Taro Kawai

Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 8　p. 2969-74　2013/02/19　Research paper (scientific journal)

Toll-Like Receptors

H. Kumar, O. Takeuchi, S. Akira

Encyclopedia of Biological Chemistry: Second Edition　p. 396-401　2013/02/15　Part of collection (book)

Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza

Daisuke Fujikura, Satoko Chiba, Daisuke Muramatsu, Mika Kazumata, Yosuke Nakayama, Taro Kawai, Shizuo Akira, Hiroshi Kida, Tadaaki Miyazaki

PLoS ONE　Vol. 8　No. 2　2013/02/08　Research paper (scientific journal)

Innate immunity

Jules Hoffmann, Shizuo Akira

Current Opinion in Immunology　Vol. 25　No. 1　p. 1-3　2013/02　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis

Chisen Takeuchi, Yoh Matsumoto, Kuniko Kohyama, Satoshi Uematsu, Shizuo Akira, Kanato Yamagata, Takako Takemiya

NEUROCHEMISTRY INTERNATIONAL　Vol. 62　No. 3　p. 271-280　2013/02　Research paper (scientific journal)

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

A. Alicia Koblansky, Dragana Jankovic, Hyunju Oh, Sara Hieny, Waradon Sungnak, Ramkumar Mathur, Matthew S. Hayden, Shizuo Akira, Alan Sher, Sankar Ghosh

Immunity　Vol. 38　No. 1　p. 119-130　2013/01/24　Research paper (scientific journal)

FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration

Hinako M. Takase, Tohru Itoh, Seitaro Ino, Ting Wang, Takehiko Koji, Shizuo Akira, Yasuhiro Takikawa, Atsushi Miyajima

Genes and Development　Vol. 27　No. 2　p. 169-181　2013　Research paper (scientific journal)

TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza a virus infection

Sabine Stegemann-Koniszewski, Marcus Gereke, Sofia Orrskog, Stefan Lienenklaus, Bastian Pasche, Sophie R. Bader, Achim D. Gruber, Shizuo Akira, Siegfried Weiss, Birgitta Henriques-Normark, Dunja Bruder, Matthias Gunzer

Journal of Innate Immunity　Vol. 5　No. 1　p. 84-96　2013　Research paper (scientific journal)

CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin

Akihiko Ichikawa, Keiji Kuba, Masayuki Morita, Shinsuke Chida, Hiroyuki Tezuka, Hiromitsu Hara, Takehiko Sasaki, Toshiaki Ohteki, V. Marco Ranieri, Claudia C. dos Santos, Yoshihiro Kawaoka, Shizuo Akira, Andrew D. Luster, Bao Lu, Josef M. Penninger, Stefan Uhlig, Arthur S. Slutsky, Yumiko Imai

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　Vol. 187　No. 1　p. 65-77　2013/01　Research paper (scientific journal)

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

Marcus Dorner, Joshua A. Horwitz, Bridget M. Donovan, Rachael N. Labitt, William C. Budell, Tamar Friling, Alexander Vogt, Maria Teresa Catanese, Takashi Satoh, Taro Kawai, Shizuo Akira, Mansun Law, Charles M. Rice, Alexander Ploss

Nature　Vol. 501　No. 7466　p. 237-241　2013　Research paper (scientific journal)

Physiological role and differentiation mechanism of various M2 macrophages

Takashi Satoh, Shizuo Akira

Japanese Journal of Allergology　Vol. 62　No. 12　p. 1575-1582　2013　Research paper (scientific journal)

A Parzen window-based approach for the detection of locally enriched transcription factor binding sites

Alexis Vandenbon, Yutaro Kumagai, Shunsuke Teraguchi, Karlou Mar Amada, Shizuo Akira, Daron M. Standley

BMC BIOINFORMATICS　Vol. 14　2013/01　Research paper (scientific journal)

Ifit1 inhibits japanese encephalitis virus replication through binding to 5= capped 2'-o unmethylated RNA

Taishi Kimura, Hiroshi Katoh, Hisako Kayama, Hiroyuki Saiga, Megumi Okuyama, Toru Okamoto, Eiji Umemoto, Yoshiharu Matsuur, Masahiro Yamamoto, Kiyoshi Takeda

Journal of Virology　Vol. 87　No. 18　p. 9997-10003　2013　Research paper (scientific journal)

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

Kenta Maruyama, Satoshi Uematsu, Takeshi Kondo, Osamu Takeuchi, Mikaël M. Martino, Takumi Kawasaki, Shizuo Akira

Journal of Experimental Medicine　Vol. 210　No. 10　p. 1947-1960　2013　Research paper (scientific journal)

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Haraguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, Tamotsu Yoshimori

Journal of Cell Biology　Vol. 203　No. 1　p. 115-128　2013　Research paper (scientific journal)

Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

Jun Kunisawa, Masashi Gohda, Eri Hashimoto, Izumi Ishikawa, Morio Higuchi, Yuji Suzuki, Yoshiyuki Goto, Casandra Panea, Ivaylo I. Ivanov, Risa Sumiya, Lamichhane Aayam, Taichi Wake, So Tajiri, Yosuke Kurashima, Shiori Shikata, Shizuo Akira, Kiyoshi Takeda, Hiroshi Kiyono

Nature Communications　Vol. 4　2013　Research paper (scientific journal)

Regnase-1, a ribonuclease involved in the regulation of immune responses

Shizuo Akira

Cold Spring Harbor Symposia on Quantitative Biology　Vol. 78　No. 1　p. 51-60　2013　Research paper (scientific journal)

Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node

Adriana Flores-Langarica, Jennifer L. Marshall, Jessica Hitchcock, Charlotte Cook, Jonathan Jobanputra, Saeeda Bobat, Ewan A. Ross, Ruth E. Coughlan, Ian R. Henderson, Satoshi Uematsu, Shizuo Akira, Adam F. Cunningham

Journal of Immunology　Vol. 189　No. 12　p. 5745-5754　2012/12/15　Research paper (scientific journal)

The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation

Kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, Shizuo Akira

Immunity　Vol. 37　No. 6　p. 1024-1036　2012/12/14　Research paper (scientific journal)

Cutting edge: Nitric oxide inhibits the NLRP3 inflammasome

Eduardo Hernandez-Cuellar, Kohsuke Tsuchiya, Hideki Hara, Rendong Fang, Shunsuke Sakai, Ikuo Kawamura, Shizuo Akira, Masao Mitsuyama

Journal of Immunology　Vol. 189　No. 11　p. 5113-5117　2012/12/01　Research paper (scientific journal)

Crucial Role of Gamma Interferon-Producing CD4(+) Th1 Cells but Dispensable Function of CD8(+) T Cell, B Cell, Th2, and Th17 Responses in the Control of Brucella melitensis Infection in Mice

Marie-Alice Vitry, Carl De Trez, Stanislas Goriely, Laure Dumoutier, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Jean-Jacques Letesson, Eric Muraille

INFECTION AND IMMUNITY　Vol. 80　No. 12　p. 4271-4280　2012/12　Research paper (scientific journal)

IPS-1 Signaling Has a Nonredundant Role in Mediating Antiviral Responses and the Clearance of Respiratory Syncytial Virus

Tine Demoor, Bryan C. Petersen, Susan Morris, Sumanta Mukherjee, Catherine Ptaschinski, Denise E. De Almeida Nagata, Taro Kawai, Toshihiro Ito, Shizuo Akira, Steven L. Kunkel, Matthew A. Schaller, Nicholas W. Lukacs

JOURNAL OF IMMUNOLOGY　Vol. 189　No. 12　p. 5942-5953　2012/12　Research paper (scientific journal)

Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction

Minoru Shigekawa, Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Wei Li, Akio Uemura, Takuya Miyagi, Atsushi Hosui, Tatsuya Kanto, Naoki Hiramatsu, Tomohide Tatsumi, Kiyoshi Takeda, Shizuo Akira, Tetsuo Takehara

American Journal of Pathology　Vol. 181　No. 6　p. 2105-2113　2012/12　Research paper (scientific journal)

A novel unbiased measure for motif co-occurrence predicts combinatorial regulation of transcription

Alexis Vandenbon, Yutaro Kumagai, Shizuo Akira, Daron M. Standley

BMC GENOMICS　Vol. 13　2012/12　Research paper (scientific journal)

Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism

Hong Zhao, Aki Konishi, Yukiko Fujita, Masanori Yagi, Keiichi Ohata, Taiki Aoshi, Sawako Itagaki, Shintaro Sato, Hirotaka Narita, Noha H. Abdelgelil, Megumi Inoue, Richard Culleton, Osamu Kaneko, Atsushi Nakagawa, Toshihiro Horii, Shizuo Akira, Ken J. Ishii, Cevayir Coban

Cell Host and Microbe　Vol. 12　No. 5　p. 705-716　2012/11/15　Research paper (scientific journal)

A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability

Stephanie L. Moon, John R. Anderson, Yutaro Kumagai, Carol J. Wilusz, Shizuo Akira, Alexander A. Khromykh, Jeffrey Wilusz

RNA-A PUBLICATION OF THE RNA SOCIETY　Vol. 18　No. 11　p. 2029-2040　2012/11　Research paper (scientific journal)

[Physiological roles and differentiation mechanism of M2 macrophage].

Satoh T, Akira S

Nihon rinsho. Japanese journal of clinical medicine　Vol. 70 Suppl 8　p. 236-241　2012/11

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure (vol 485, pg 251, 2012)

Oka Takafumi, Hikoso Shungo, Yamaguchi Osamu, Taneike Manabu, Takeda Toshihiro, Tamai Takahito, Oyabu Jota, Murakawa Tomokazu, Nakayama Hiroyuki, Nishida Kazuhiko, Akira Shizuo, Yamamoto Akitsugu, Komuro Issei, Otsu Kinya

NATURE　Vol. 490　No. 7419　2012/10/11

PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells

Takuma Shibata, Naoki Takemura, Yuji Motoi, Yoshiyuki Goto, Thangaraj Karuppuchamy, Kumi Izawa, Xiaobing Li, Sachiko Akashi-takamura, Natsuko Tanimura, Jun Kunisawa, Hiroshi Kiyono, Shizuo Akira, Toshio Kitamura, Jiro Kitaura, Satoshi Uematsu, Kensuke Miyake

International Immunology　Vol. 24　No. 10　p. 613-623　2012/10　Research paper (scientific journal)

Distinct Modulated Pupil Function System for Real-Time Imaging of Living Cells

Tomonobu M. Watanabe, Yoshikazu Tsukasaki, Hideaki Fujita, Taro Ichimura, Tatsuya Saitoh, Shizuo Akira, Toshio Yanagida

PLoS ONE　Vol. 7　No. 9　2012/09/04　Research paper (scientific journal)

Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

Penny A. Rudd, Jane Wilson, Joy Gardner, Thibaut Larcher, Candice Babarit, Thuy T. Le, Itaru Anraku, Yutaro Kumagai, Yueh-Ming Loo, Michael Gale, Shizuo Akira, Alexander A. Khromykh, Andreas Suhrbier

JOURNAL OF VIROLOGY　Vol. 86　No. 18　p. 9888-9898　2012/09　Research paper (scientific journal)

Systems biology approaches to toll-like receptor signaling

Alexis Vandenbon, Shunsuke Teraguchi, Shizuo Akira, Kiyoshi Takeda, Daron M. Standley

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE　Vol. 4　No. 5　p. 497-507　2012/09　Research paper (scientific journal)

Dissecting negative regulation of Toll-like receptor signaling

Takeshi Kondo, Taro Kawai, Shizuo Akira

Trends in Immunology　Vol. 33　No. 9　p. 449-458　2012/09　Research paper (scientific journal)

A cluster of interferon-γ-inducible p65 gtpases plays a critical role in host defense against toxoplasma gondii

Masahiro Yamamoto, Megumi Okuyama, Ji Su Ma, Taishi Kimura, Naganori Kamiyama, Hiroyuki Saiga, Jun Ohshima, Miwa Sasai, Hisako Kayama, Toru Okamoto, David C.S. Huang, Dominique Soldati-Favre, Kyoji Horie, Junji Takeda, Kiyoshi Takeda

Immunity　Vol. 37　No. 2　p. 302-313　2012/08/24　Research paper (scientific journal)

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

Masaki Shoji, Masashi Tachibana, Kazufumi Katayama, Kyoko Tomita, Sayaka Tsuzuki, Fuminori Sakurai, Kenji Kawabata, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi

Biochemical and Biophysical Research Communications　Vol. 425　No. 1　p. 89-93　2012/08/17　Research paper (scientific journal)

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation

Kenta Maruyama, Tatsukata Kawagoe, Takeshi Kondo, Shizuo Akira, Osamu Takeuchi

Journal of Biological Chemistry　Vol. 287　No. 34　p. 29114-29124　2012/08/17　Research paper (scientific journal)

Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35

Yukiko Kuroki, Yuka Sasaki, Daisuke Kamei, Yoshiharu Akitake, Mitsuo Takahashi, Satoshi Uematsu, Shizuo Akira, Yoshihito Nakatani, Ichiro Kudo, Shuntaro Hara

Biochemical and Biophysical Research Communications　Vol. 424　No. 3　p. 409-413　2012/08/03　Research paper (scientific journal)

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

Marina Oldenburg, Anne Krueger, Ruth Ferstl, Andreas Kaufmann, Gernot Nees, Anna Sigmund, Barbara Bathke, Henning Lauterbach, Mark Suter, Stefan Dreher, Uwe Koedel, Shizuo Akira, Taro Kawai, Jan Buer, Hermann Wagner, Stefan Bauer, Hubertus Hochrein, Carsten J. Kirschning

SCIENCE　Vol. 337　No. 6098　p. 1111-1115　2012/08　Research paper (scientific journal)

Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis

Jennifer L. Berard, Juan G. Zarruk, Nathalie Arbour, Alexandre Prat, V. Wee Yong, Francois H. Jacques, Shizuo Akira, Samuel David

GLIA　Vol. 60　No. 7　p. 1145-1159　2012/07　Research paper (scientific journal)

Leukemia Inhibitory Factor Coordinates the Down-regulation of the Visual Cycle in the Retina and Retinal-pigmented Epithelium

Ana J. Chucair-Elliott, Michael H. Elliott, Jiangang Wang, Gennadiy P. Moiseyev, Jian-Xing Ma, Luis E. Politi, Nora P. Rotstein, Shizuo Akira, Satoshi Uematsu, John D. Ash

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 287　No. 29　p. 24092-24102　2012/07　Research paper (scientific journal)

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity

Martin Kreutz, Benoit Giquel, Qin Hu, Ram Abuknesha, Satoshi Uematsu, Shizuo Akira, Frank O. Nestle, Sandra S. Diebold

PLOS ONE　Vol. 7　No. 7　2012/07　Research paper (scientific journal)

A critical role of IL-33 in experimental allergic rhinitis

Yoko Haenuki, Kazufumi Matsushita, Shizue Futatsugi-Yumikura, Ken J. Ishii, Tatsukata Kawagoe, Yoshimasa Imoto, Shigeharu Fujieda, Makoto Yasuda, Yasuo Hisa, Shizuo Akira, Kenji Nakanishi, Tomohiro Yoshimoto

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 130　No. 1　p. 184-+　2012/07　Research paper (scientific journal)

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

Tatsuya Saitoh, Jun Komano, Yasunori Saitoh, Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Takuya Uehata, Hidenori Iwasaki, Hiroko Omori, Shoji Yamaoka, Naoki Yamamoto, Shizuo Akira

Cell Host & Microbe　Vol. 12　No. 1　p. 109-116　2012/07　Research paper (scientific journal)

Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.

Shoichi Ihara, Hiroshi Kida, Hisashi Arase, Lokesh P Tripathi, Yi-An Chen, Tetsuya Kimura, Mitsuhiro Yoshida, Yozo Kashiwa, Haruhiko Hirata, Reiko Fukamizu, Ruriko Inoue, Kana Hasegawa, Sho Goya, Ryo Takahashi, Toshiyuki Minami, Kazuyuki Tsujino, Mayumi Suzuki, Satoshi Kohmo, Koji Inoue, Izumi Nagatomo, Yoshito Takeda, Takashi Kijima, Kenji Mizuguchi, Isao Tachibana, Atsushi Kumanogoh

Cancer research　Vol. 72　No. 12　p. 2990-9　2012/06/15　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis

Y. Sasaki, D. Kamei, Y. Ishikawa, T. Ishii, S. Uematsu, S. Akira, M. Murakami, S. Hara

Oncogene　Vol. 31　No. 24　p. 2943-2952　2012/06/14　Research paper (scientific journal)

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Takashi Shichita, Eiichi Hasegawa, Akihiro Kimura, Rimpei Morita, Ryota Sakaguchi, Ichiro Takada, Takashi Sekiya, Hiroaki Ooboshi, Takanari Kitazono, Toru Yanagawa, Tetsuro Ishii, Hideo Takahashi, Shuji Mori, Masahiro Nishibori, Kazumichi Kuroda, Shizuo Akira, Kensuke Miyake, Akihiko Yoshimura

Nature Medicine　Vol. 18　No. 6　p. 911-917　2012/06　Research paper (scientific journal)

[Nucleic acids recognition by innate immunity].

Akira S, Saitoh T, Kawai T

Uirusu　Vol. 62　No. 1　p. 39-45　2012/06

CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan

Takayuki Abe, Takasuke Fukuhara, Xiauyu Wen, Akinori Ninomiya, Kohji Moriishi, Yoshihiko Maehara, Osamu Takeuchi, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura

Journal of Virology　Vol. 86　No. 11　p. 6159-6170　2012/06　Research paper (scientific journal)

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.

Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro, Kinya Otsu

Nature　Vol. 485　No. 7397　p. 251-5　2012/05/10　Research paper (scientific journal)

The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation

Yasuharu Watanabe, Tomoya Nakamura, Sho Ishikawa, Shiho Fujisaka, Isao Usui, Koichi Tsuneyama, Yoshinori Ichihara, Tsutomu Wada, Yoichiro Hirata, Takayoshi Suganami, Hirofumi Izaki, Shizuo Akira, Kensuke Miyake, Hiro-omi Kanayama, Michio Shimabukuro, Masataka Sata, Toshiyasu Sasaoka, Yoshihiro Ogawa, Kazuyuki Tobe, Kiyoshi Takatsu, Yoshinori Nagai

DIABETES　Vol. 61　No. 5　p. 1199-1209　2012/05　Research paper (scientific journal)

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

Jae-Hoon Chang, Yichuan Xiao, Hongbo Hu, Jin Jin, Jiayi Yu, Xiaofei Zhou, Xuefeng Wu, Howard M. Johnson, Shizuo Akira, Manolis Pasparakis, Xuhong Cheng, Shao-Cong Sun

NATURE IMMUNOLOGY　Vol. 13　No. 5　p. 481-U84　2012/05　Research paper (scientific journal)

Hepatocyte-specific mutation of both NF-kappa B RelA and STAT3 abrogates the acute phase response in mice

Lee J. Quinton, Matthew T. Blahna, Matthew R. Jones, Eri Allen, Joseph D. Ferrari, Kristie L. Hilliard, Xiaoling Zhang, Vishakha Sabharwal, Hana Alguel, Shizuo Akira, Roland M. Schmid, Stephen I. Pelton, Avrum Spira, Joseph P. Mizgerd

JOURNAL OF CLINICAL INVESTIGATION　Vol. 122　No. 5　p. 1758-1763　2012/05　Research paper (scientific journal)

Muramyl Dipeptide Induces NOD2-Dependent Ly6C(high) Monocyte Recruitment to the Lungs and Protects Against Influenza Virus Infection

Francois Coulombe, Stephanie Fiola, Shizuo Akira, Yvon Cormier, Jean Gosselin

PLOS ONE　Vol. 7　No. 5　2012/05　Research paper (scientific journal)

West Nile Virus Noncoding Subgenomic RNA Contributes to Viral Evasion of the Type I Interferon-Mediated Antiviral Response

Andrea Schuessler, Anneke Funk, Helen M. Lazear, Daphne A. Cooper, Shessy Torres, Stephane Daffis, Babal Kant Jha, Yutaro Kumagai, Osamu Takeuchi, Paul Hertzog, Robert Silverman, Shizuo Akira, David J. Barton, Michael S. Diamond, Alexander A. Khromykh

JOURNAL OF VIROLOGY　Vol. 86　No. 10　p. 5708-5718　2012/05　Research paper (scientific journal)

Novel bacterial lipoprotein structures conserved in low-GC content gram-positive bacteria are recognized by Toll-like receptor 2.

Kenji Kurokawa, Kyoung-Hwa Ryu, Rie Ichikawa, Akiko Masuda, Min-Su Kim, Hanna Lee, Jun-Ho Chae, Takashi Shimizu, Tatsuya Saitoh, Koichi Kuwano, Shizuo Akira, Naoshi Dohmae, Hiroshi Nakayama, Bok Luel Lee

The Journal of biological chemistry　Vol. 287　No. 16　p. 13170-81　2012/04/13　Research paper (scientific journal)

不全心におけるミトコンドリアDNA分解の重要性

岡 崇史, 彦惣 俊吾, 山口 修, 武田 理宏, 中山 博之, 西田 和彦, 審良 静男, 山本 章嗣, 小室 一成, 大津 欣也

日本臨床分子医学会学術総会プログラム・抄録集　Vol. 49回　p. 89-89　2012/04

Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

Linda M. Bradley, Mia F. Douglass, Dhrubamitra Chatterjee, Shizuo Akira, Bas J. G. Baaten

PLOS PATHOGENS　Vol. 8　No. 4　2012/04　Research paper (scientific journal)

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

Koon-Guan Lee, Shengli Xu, Zi-Han Kang, Jianxin Huo, Mei Huang, Dingxiang Liu, Osamu Takeuchi, Shizuo Akira, Kong-Peng Lam

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 109　No. 15　p. 5791-5796　2012/04　Research paper (scientific journal)

Guidelines for the use and interpretation of assays for monitoring autophagy.

Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A Aguirre-Ghiso, Hyung Jun Ahn, Ouardia Ait-Mohamed, Slimane Ait-Si-Ali, Takahiko Akematsu, Shizuo Akira, Hesham M Al-Younes, Munir A Al-Zeer, Matthew L Albert, Roger L Albin, Javier Alegre-Abarrategui, Maria Francesca Aleo, Mehrdad Alirezaei, Alexandru Almasan, Maylin Almonte-Becerril, Atsuo Amano, Ravi Amaravadi, Shoba Amarnath, Amal O Amer, Nathalie Andrieu-Abadie, Vellareddy Anantharam, David K Ann, Shailendra Anoopkumar-Dukie, Hiroshi Aoki, Nadezda Apostolova, Giuseppe Arancia, John P Aris, Katsuhiko Asanuma, Nana Y O Asare, Hisashi Ashida, Valerie Askanas, David S Askew, Patrick Auberger, Misuzu Baba, Steven K Backues, Eric H Baehrecke, Ben A Bahr, Xue-Yuan Bai, Yannick Bailly, Robert Baiocchi, Giulia Baldini, Walter Balduini, Andrea Ballabio, Bruce A Bamber, Edward T W Bampton, Gábor Bánhegyi, Clinton R 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Binfeng Lu, Bingwei Lu, Bo Lu, Zhen Lu, Frédéric Luciano, Nicholas W Lukacs, Anders H Lund, Melinda A Lynch-Day, Yong Ma, Fernando Macian, Jeff P MacKeigan, Kay F Macleod, Frank Madeo, Luigi Maiuri, Maria Chiara Maiuri, Davide Malagoli, May Christine V Malicdan, Walter Malorni, Na Man, Eva-Maria Mandelkow, Stéphen Manon, Irena Manov, Kai Mao, Xiang Mao, Zixu Mao, Philippe Marambaud, Daniela Marazziti, Yves L Marcel, Katie Marchbank, Piero Marchetti, Stefan J Marciniak, Mateus Marcondes, Mohsen Mardi, Gabriella Marfe, Guillermo Mariño, Maria Markaki, Mark R Marten, Seamus J Martin, Camille Martinand-Mari, Wim Martinet, Marta Martinez-Vicente, Matilde Masini, Paola Matarrese, Saburo Matsuo, Raffaele Matteoni, Andreas Mayer, Nathalie M Mazure, David J McConkey, Melanie J McConnell, Catherine McDermott, Christine McDonald, Gerald M McInerney, Sharon L McKenna, BethAnn McLaughlin, Pamela J McLean, Christopher R McMaster, G Angus McQuibban, Alfred J Meijer, Miriam H Meisler, Alicia Meléndez, 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Autophagy　Vol. 8　No. 4　p. 445-544　2012/04　Research paper (scientific journal)

マラリア代謝産物Hemozoinならびにそのワクチンアジュバントとしての有用性について

大畑 敬一, 八木 正典, 猪狩 義勝, 津久井 利広, 福井 真人, 堀井 俊宏, 審良 静男, 石井 健, Coban C.

獣医寄生虫学会誌　Vol. 10　No. 1-2　p. 33-33　2012/03

In Situ Microscopy Analysis Reveals Local Innate Immune Response Developed around Brucella Infected Cells in Resistant and Susceptible Mice

Richard Copin, Marie-Alice Vitry, Delphine Hanot Mambres, Arnaud Machelart, Carl De Trez, Jean-Marie Vanderwinden, Stefan Magez, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Jean-Jacques Letesson, Eric Muraille

PLOS PATHOGENS　Vol. 8　No. 3　2012/03　Research paper (scientific journal)

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

Koubun Yasuda, Taichiro Muto, Tatsukata Kawagoe, Makoto Matsumoto, Yuki Sasaki, Kazufumi Matsushita, Yuko Taki, Shizue Futatsugi-Yumikura, Hiroko Tsutsui, Ken J. Ishii, Tomohiro Yoshimoto, Shizuo Akira, Kenji Nakanishi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 109　No. 9　p. 3451-3456　2012/02/28　Research paper (scientific journal)

Role of TLRs in Brucella mediated murine DC activation in vitro and clearance of pulmonary infection in vivo

Naveen Surendran, Elizabeth M. Hiltbold, Bettina Held, Shizuo Akira, Theodore J. Standiford, Nammalwar Sriranganathan, Stephen M. Boyle, Kurt L. Zimmerman, Melissa R. Makris, Sharon G. Witonsky

VACCINE　Vol. 30　No. 8　p. 1502-1512　2012/02　Research paper (scientific journal)

MS3-5 アレルギー性鼻炎モデルマウスにおける内因性IL-33の病因的役割(MS3 花粉症・鼻アレルギー,ミニシンポジウム,第62回日本アレルギー学会秋季学術大会)

萠拔 陽子, 久 育男, 中西 憲司, 審良 静男, 善本 知広

アレルギー　Vol. 61　No. 9　p. 1439-1439　2012

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Eddy T. H. Goh, J. Simon C. Arthur, Peter C. F. Cheung, Shizuo Akira, Rachel Toth, Philip Cohen

BIOCHEMICAL JOURNAL　Vol. 441　p. 339-346　2012/01　Research paper (scientific journal)

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS

Angela Dann, Hendrik Poeck, Andrew L. Croxford, Stefanie Gaupp, Katrin Kierdorf, Markus Knust, Dietmar Pfeifer, Cornelius Maihoefer, Stefan Endres, Ulrich Kalinke, Sven G. Meuth, Heinz Wiendl, Klaus-Peter Knobeloch, Shizuo Akira, Ari Waisman, Gunther Hartmann, Marco Prinz

NATURE NEUROSCIENCE　Vol. 15　No. 1　p. 98-U126　2012/01　Research paper (scientific journal)

NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA

Sachin D. Deshmukh, Sabrina Mueller, Katrin Hese, Katharina S. Rauch, Julia Wennekamp, Osamu Takeuchi, Shizuo Akira, Douglas T. Golenbock, Philipp Henneke

JOURNAL OF IMMUNOLOGY　Vol. 188　No. 2　p. 774-780　2012/01　Research paper (scientific journal)

The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice

Yuko Abe, Ken Fujii, Noriyo Nagata, Osamu Takeuchi, Shizuo Akira, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya, Satoshi Koike

JOURNAL OF VIROLOGY　Vol. 86　No. 1　p. 185-194　2012/01　Research paper (scientific journal)

Essential roles of Tab2 and Tab3 1n the activation of MAPK, but not NF-kB, in B cells.

Ori D, Kato H, Sanjo H, Akira S, Takeuchi O

2012 Annual Meeting of Japanese Society for Immunology. No. 1-E 一W7-3-0/P, Kobe, December 5-7, 2012.　2012

Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice

Wataru Yoshioka, Keiko Aida-Yasuoka, Nozomi Fujisawa, Tatsuya Kawaguchi, Seiichiroh Ohsako, Shuntaro Hara, Satoshi Uematsu, Shizuo Akira, Chiharu Tohyama

Toxicological Sciences　Vol. 127　No. 2　p. 547-554　2012　Research paper (scientific journal)

Contribution of LGP2 to Viral Recognition Pathways.

Takeuchi O, Akira S

Nucleic Acid Sensors and Antiviral Immunity, Landes Bioscience, 2012.　2012

Stochastic binary modeling of cells in continuous time as an alternative to biochemical reaction equations

Shunsuke Teraguchi, Yutaro Kumagai, Alexis Vandenbon, Shizuo Akira, Daron M. Standley

PHYSICAL REVIEW E　Vol. 84　No. 6　2011/12　Research paper (scientific journal)

Novel strategies to improve DNA vaccine immunogenicity

Cevayir Coban, Kouji Kobiyama, Taiki Aoshi, Fumihiko Takeshita, Toshihiro Horii, Shizuo Akira, Ken J. Ishii

Current Gene Therapy　Vol. 11　No. 6　p. 479-484　2011/12　Research paper (scientific journal)

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

Hidenori Iwasaki, Osamu Takeuchi, Shunsuke Teraguchi, Kazufumi Matsushita, Takuya Uehata, Kanako Kuniyoshi, Takashi Satoh, Tatsuya Saitoh, Mutsuyoshi Matsushita, Daron M. Standley, Shizuo Akira

Nature Immunology　Vol. 12　No. 12　p. 1167-1175　2011/12　Research paper (scientific journal)

MyD88 Plays an Essential Role in Inducing B Cells Capable of Differentiating into Antibody-Secreting Cells after Vaccination

Sang-Moo Kang, Dae-Goon Yoo, Min-Chul Kim, Jae-Min Song, Min-Kyung Park, O. Eunju, Fu-Shi Quan, Shizuo Akira, Richard W. Compans

JOURNAL OF VIROLOGY　Vol. 85　No. 21　p. 11391-11400　2011/11　Research paper (scientific journal)

Effect of Toll-like receptor 2 and 4 of corneal fibroblasts on cytokine expression with co-cultured antigen presenting cells

Hyuk Jin Choi, Mee Kum Kim, Jung Hwa Ko, Hyun Ju Lee, Hyun Jeong Jeong, Won Ryang Wee, Seung-Yong Seong, Shizuo Akira

CYTOKINE　Vol. 56　No. 2　p. 265-271　2011/11　Research paper (scientific journal)

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription

Hideki Hayashi, Tomoko Kohno, Kiyoshi Yasui, Hiroyuki Murota, Tohru Kimura, Gordon S. Duncan, Tomoki Nakashima, Kazuo Yamamoto, Ichiro Katayama, Yuhua Ma, Koon Jiew Chua, Takashi Suematsu, Isao Shimokawa, Shizuo Akira, Yoshinao Kubo, Tak Wah Mak, Toshifumi Matsuyama

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 108　No. 46　p. 18766-18771　2011/11　Research paper (scientific journal)

The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A

Ana Paula Moreira, Karen A. Cavassani, Ugur B. Ismailoglu, Rikki Hullinger, Michael P. Dunleavy, Darryl A. Knight, Steven L. Kunkel, Satoshi Uematsu, Shizuo Akira, Cory M. Hogaboam

JOURNAL OF CLINICAL INVESTIGATION　Vol. 121　No. 11　p. 4420-4432　2011/11　Research paper (scientific journal)

The TRAF-associated protein TANK facilitates cross-talk within the I kappa B kinase family during Toll-like receptor signaling

Kristopher Clark, Osamu Takeuchi, Shizuo Akira, Philip Cohen

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 108　No. 41　p. 17093-17098　2011/10　Research paper (scientific journal)

TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

Hye Sung Kim, Heounjeong Go, Shizuo Akira, Doo Hyun Chung

JOURNAL OF IMMUNOLOGY　Vol. 187　No. 8　p. 4007-4017　2011/10　Research paper (scientific journal)

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane

Tolga T. Barker, Pui Y. Lee, Kindra M. Kelly-Scumpia, Jason S. Weinstein, Dina C. Nacionales, Yutaro Kumagai, Shizuo Akira, Byron P. Croker, Eric S. Sobel, Westley H. Reeves, Minoru Satoh

LABORATORY INVESTIGATION　Vol. 91　No. 10　p. 1540-1550　2011/10　Research paper (scientific journal)

Mind Bomb Proteins in the Antiviral Arsenal

Yutaro Kumagai, Shizuo Akira

Immunity　Vol. 35　No. 3　p. 320-322　2011/09/23

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

M. Neubert, D. A. Ridder, P. Bargiotas, S. Akira, M. Schwaninger

Cell Death and Differentiation　Vol. 18　No. 9　p. 1521-1530　2011/09　Research paper (scientific journal)

Lipocalin 2 Plays an Immunomodulatory Role and Has Detrimental Effects after Spinal Cord Injury

Khizr I. Rathore, Jennifer L. Berard, Adriana Redensek, Sabrina Chierzi, Ruben Lopez-Vales, Manuela Santos, Shizuo Akira, Samuel David

JOURNAL OF NEUROSCIENCE　Vol. 31　No. 38　p. 13412-13419　2011/09　Research paper (scientific journal)

Epigenetic control of macrophage polarization

Osamu Takeuch, Shizuo Akira

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 41　No. 9　p. 2490-2493　2011/09　Research paper (scientific journal)

Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity

Takumi Kawasaki, Taro Kawai, Shizuo Akira

Immunological Reviews　Vol. 243　No. 1　p. 61-73　2011/09

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

Taro Kawai, Shizuo Akira

EMBO Molecular Medicine　Vol. 3　No. 9　p. 513-527　2011/09

[Role of PRRs in vaccine].

Kumagai Y, Akira S

Nihon rinsho. Japanese journal of clinical medicine　Vol. 69　No. 9　p. 1541-1546　2011/09

マラリア代謝産物Hemozoinならびにそのワクチンアジュバントとしての有用性について

大畑 敬一, 八木 正典, 猪狩 義勝, 津久井 利広, 福井 真人, 堀井 俊宏, 審良 静男, 石井 健, Cevayir Coban

日本獣医学会学術集会講演要旨集　Vol. 152回　p. 202-202　2011/08

Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin

Daniel M. Andrews, Melvyn T. Chow, Yuting Ma, Claire L. Cotterell, Sally V. Watt, Desiree A. Anthony, Shizuo Akira, Yoichiro Iwakura, Joseph A. Trapani, Laurence Zitvogel, Mark J. Smyth

IMMUNOLOGY AND CELL BIOLOGY　Vol. 89　No. 6　p. 739-746　2011/08　Research paper (scientific journal)

B cells enhance early innate immune responses during bacterial sepsis

Kindra M. Kelly-Scumpia, Philip O. Scumpia, Jason S. Weinstein, Matthew J. Delano, Alex G. Cuenca, Dina C. Nacionales, James L. Wynn, Pui Y. Lee, Yutaro Kumagai, Philip A. Efron, Shizuo Akira, Clive Wasserfall, Mark A. Atkinson, Lyle L. Moldawer

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 208　No. 8　p. 1673-1682　2011/08　Research paper (scientific journal)

DNA released from dying host cells mediates aluminum adjuvant activity

Thomas Marichal, Keiichi Ohata, Denis Bedoret, Claire Mesnil, Catherine Sabatel, Kouji Kobiyama, Pierre Lekeux, Cevayir Coban, Shizuo Akira, Ken J. Ishii, Fabrice Bureau, Christophe J. Desmet

Nature Medicine　Vol. 17　No. 8　p. 996-1002　2011/08　Research paper (scientific journal)

ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18

Masahiro Yamamoto, Ji Su Ma, Christina Mueller, Naganori Kamiyama, Hiroyuki Saiga, Emi Kubo, Taishi Kimura, Toru Okamoto, Megumi Okuyama, Hisako Kayama, Kisaburo Nagamune, Seiji Takashima, Yoshiharu Matsuura, Dominique Soldati-Favre, Kiyoshi Takeda

Journal of Experimental Medicine　Vol. 208　No. 7　p. 1533-1546　2011/07/04　Research paper (scientific journal)

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, Kensuke Miyake

IMMUNITY　Vol. 35　No. 1　p. 69-81　2011/07　Research paper (scientific journal)

Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice

Koichiro Matsumoto, Keiko Kan-o, Miyuki Eguchi-Tsuda, Satoru Fukuyama, Yukari Asai, Takafumi Matsumoto, Atsushi Moriwaki, Yuko Matsunaga, Hiroko Tsutsui, Taro Kawai, Osamu Takeuchi, Shizuo Akira, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue

American Journal of Respiratory Cell and Molecular Biology　Vol. 45　No. 1　p. 31-39　2011/07/01　Research paper (scientific journal)

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.

Shun Kageyama, Hiroko Omori, Tatsuya Saitoh, Takefumi Sone, Jun-Lin Guan, Shizuo Akira, Fumio Imamoto, Takeshi Noda, Tamotsu Yoshimori

Molecular biology of the cell　Vol. 22　No. 13　p. 2290-300　2011/07/01　Research paper (scientific journal)

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections

Yun-Gi Kim, Jong-Hwan Park, Thornik Reimer, Darren P. Baker, Taro Kawai, Himanshu Kumar, Shizuo Akira, Christiane Wobus, Gabriel Núñez

Cell Host and Microbe　Vol. 9　No. 6　p. 496-507　2011/06/16　Research paper (scientific journal)

A new subset of CD103+CD8α+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity

Kosuke Fujimoto, Thangaraj Karuppuchamy, Naoki Takemura, Masaki Shimohigoshi, Tomohisa Machida, Yasunari Haseda, Taiki Aoshi, Ken J. Ishii, Shizuo Akira, Satoshi Uematsu

Journal of Immunology　Vol. 186　No. 11　p. 6287-6295　2011/06/01　Research paper (scientific journal)

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).

Sumihito Togi, Osamu Ikeda, Shinya Kamitani, Misa Nakasuji, Yuichi Sekine, Ryuta Muromoto, Asuka Nanbo, Kenji Oritani, Taro Kawai, Shizuo Akira, Tadashi Matsuda

The Journal of biological chemistry　Vol. 286　No. 21　p. 19170-7　2011/05/27　Research paper (scientific journal)

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

Taro Kawai, Shizuo Akira

Immunity　Vol. 34　No. 5　p. 637-650　2011/05/27

Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway

Sophia Davidson, Gerard Kaiko, Zhixuan Loh, Amit Lalwani, Vivian Zhang, Kirsten Spann, Shen Yun Foo, Nicole Hansbro, Satoshi Uematsu, Shizuo Akira, Klaus I. Matthaei, Helene F. Rosenberg, Paul S. Foster, Simon Phipps

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 10　p. 5938-5948　2011/05　Research paper (scientific journal)

TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen

Shirdi E. Letran, Seung-Joo Lee, Shaikh M. Atif, Adriana Flores-Langarica, Satoshi Uematsu, Shizuo Akira, Adam F. Cunningham, Stephen J. McSorley

Journal of Immunology　Vol. 186　No. 9　p. 5406-5412　2011/05/01　Research paper (scientific journal)

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

Etsushi Kuroda, Ken J. Ishii, Satoshi Uematsu, Keiichi Ohata, Cevayir Coban, Shizuo Akira, Kosuke Aritake, Yoshihiro Urade, Yasuo Morimoto

Immunity　Vol. 34　No. 4　p. 514-526　2011/04/22　Research paper (scientific journal)

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

Akihisa Fukuda, Sam C. Wang, John P. Morris, Alexandra E. Folias, Angela Liou, Grace E. Kim, Shizuo Akira, Kenneth M. Boucher, Matthew A. Firpo, Sean J. Mulvihill, Matthias Hebrok

Cancer Cell　Vol. 19　No. 4　p. 441-455　2011/04/12　Research paper (scientific journal)

Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway

Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, Naoto Kubota, Kazuma Kaneko, Masatoshi Kobayashi, Aya Iwane, Takayoshi Sasako, Yukiko Okazaki, Mitsuru Ohsugi, Iseki Takamoto, Satoshi Yamashita, Hiroshi Asahara, Shizuo Akira, Masato Kasuga, Takashi Kadowaki

Cell Metabolism　Vol. 13　No. 4　p. 401-412　2011/04/06　Research paper (scientific journal)

Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with Mycobacterium tuberculosis Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist

In Duk Jung, Soo Kyung Jeong, Chang-Min Lee, Kyung Tae Noh, Deok Rim Heo, Yong Kyoo Shin, Cheol-Heui Yun, Won-Jung Koh, Shizuo Akira, Jake Whang, Hwa-Jung Kim, Won Sun Park, Sung Jae Shin, Yeong-Min Park

CANCER RESEARCH　Vol. 71　No. 8　p. 2858-2870　2011/04　Research paper (scientific journal)

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

Marina Lesina, Magdalena U. Kurkowski, Katharina Ludes, Stefan Rose-John, Matthias Treiber, Guenter Kloeppel, Akihiko Yoshimura, Wolfgang Reindl, Bence Sipos, Shizuo Akira, Roland M. Schmid, Hana Alguel

CANCER CELL　Vol. 19　No. 4　p. 456-469　2011/04　Research paper (scientific journal)

Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice

Hendrik J. Nel, Emily Hams, Sean P. Saunders, Niamh E. Mangan, Philip Smith, Ann Atzberger, Richard A. Flavell, Shizuo Akira, Andrew N. McKenzie, Padraic G. Fallon

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 8　p. 4631-4639　2011/04　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice

Masako Isono, Tatsunori Suzuki, Kanako Hosono, Izumi Hayashi, Hiroyuki Sakagami, Satoshi Uematsu, Shizuo Akira, Yves A. DeClerck, Hirotugu Okamoto, Masataka Majima

LIFE SCIENCES　Vol. 88　No. 15-16　p. 693-700　2011/04　Research paper (scientific journal)

Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition

Erin L. Lousberg, Kerrilyn R. Diener, Cara K. Fraser, Simon Phipps, Paul S. Foster, Weisan Chen, Satoshi Uematsu, Shizuo Akira, Sarah A. Robertson, Michael P. Brown, John D. Hayball

JOURNAL OF VIROLOGY　Vol. 85　No. 7　p. 3385-3396　2011/04　Research paper (scientific journal)

Antiviral protein viperin promotes toll-like receptor 7- and toll-like receptor 9-mediated type i interferon production in plasmacytoid dendritic cells

Tatsuya Saitoh, Takashi Satoh, Naoki Yamamoto, Satoshi Uematsu, Osamu Takeuchi, Taro Kawai, Shizuo Akira

Immunity　Vol. 34　No. 3　p. 352-363　2011/03/25　Research paper (scientific journal)

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-beta Signaling

Christelle Bourgeois, Olivia Majer, Ingrid E. Frohner, Iwona Lesiak-Markowicz, Kwang-Soo Hildering, Walter Glaser, Silvia Stockinger, Thomas Decker, Shizuo Akira, Mathias Mueller, Karl Kuchler

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 5　p. 3104-3112　2011/03　Research paper (scientific journal)

TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

Mingjian Fei, Shikha Bhatia, Timothy B. Oriss, Manohar Yarlagadda, Anupriya Khare, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Beth A. Fallert Junecko, Todd A. Reinhart, Oded Foreman, Prabir Ray, Jay Kolls, Anuradha Ray

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 108　No. 13　p. 5360-5365　2011/03　Research paper (scientific journal)

Roles of an inducible prostaglandin E synthase, mPGES-1 in host in enhancement of tumor-associated angiogenesis

Kamata H, Hosono K, Suzuki T, Ogawa Y, Kubo H, Katoh H, Ito Y, Uematsu S, Akira S, Watanabe M, Majima M

The Kitasato Medical Journal　Vol. 41　No. 1　p. 19-30　2011/03

Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels

Takako Takemiya, Kiyoshi Matsumura, Hiroko Sugiura, Shin Yasuda, Satoshi Uematsu, Shizuo Akira, Kanato Yamagata

NEUROCHEMISTRY INTERNATIONAL　Vol. 58　No. 4　p. 489-496　2011/03　Research paper (scientific journal)

Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.

Yukinobu Nakagawa, Hyota Takamatsu, Tatsusada Okuno, Sujin Kang, Satoshi Nojima, Tetsuya Kimura, Tatsuki R Kataoka, Masahito Ikawa, Toshihiko Toyofuku, Ichiro Katayama, Atsushi Kumanogoh

Journal of immunology (Baltimore, Md. : 1950)　Vol. 186　No. 5　p. 2881-8　2011/03/01

Type I Interferon Signaling Regulates Ly6C(hi) Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon

PLOS PATHOGENS　Vol. 7　No. 2　2011/02　Research paper (scientific journal)

The C Proteins of Human Parainfluenza Virus Type 1 Limit Double-Stranded RNA Accumulation That Would Otherwise Trigger Activation of MDA5 and Protein Kinase R

Jim Boonyaratanakornkit, Emmalene Bartlett, Henrick Schomacker, Sonja Surman, Shizuo Akira, Yong-Soo Bae, Peter Collins, Brian Murphy, Alexander Schmidt

JOURNAL OF VIROLOGY　Vol. 85　No. 4　p. 1495-1506　2011/02　Research paper (scientific journal)

IL-1 alpha Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil

Pui Y. Lee, Yutaro Kumagai, Yuan Xu, Yi Li, Tolga Barker, Chao Liu, Eric S. Sobel, Osamu Takeuchi, Shizuo Akira, Minoru Satoh, Westley H. Reeves

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 3　p. 1747-1754　2011/02　Research paper (scientific journal)

Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice

Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon

PLoS Pathogens　Vol. 7　No. 2　2011/02　Research paper (scientific journal)

The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model

Akiko Numao, Kanako Hosono, Tatsunori Suzuki, Izumi Hayashi, Satoshi Uematsu, Shizuo Akira, Yukiko Ogino, Hirohito Kawauchi, Nobuya Unno, Masataka Majima

BIOMEDICINE & PHARMACOTHERAPY　Vol. 65　No. 1　p. 77-84　2011/02　Research paper (scientific journal)

NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections

Himanshu Kumar, Surya Pandey, Jian Zou, Yutaro Kumagai, Ken Takahashi, Shizuo Akira, Taro Kawai

Journal of Immunology　Vol. 186　No. 2　p. 994-1000　2011/01/15　Research paper (scientific journal)

Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype

Shikha Bhatia, Mingjian Fei, Manohar Yarlagadda, Zengbiao Qi, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Nico van Rooijen, Gregory A. Gibson, Claudette M. St Croix, Anuradha Ray, Prabir Ray

PLOS ONE　Vol. 6　No. 1　2011/01　Research paper (scientific journal)

Activation of Lipopolysaccharide-TLR4 Signaling Accelerates the Ototoxic Potential of Cisplatin in Mice

Gi-Su Oh, Hyung-Jin Kim, Jae-Hyuck Choi, AiHua Shen, Chang-Hoi Kim, Se-Jin Kim, Sae-Ron Shin, Seung-Heon Hong, Yunha Kim, Channy Park, Sung-Joong Lee, Shizuo Akira, Raekil Park, Hong-Seob So

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 2　p. 1140-1150　2011/01　Research paper (scientific journal)

MyD88-Dependent Signaling Protects against Anthrax Lethal Toxin-Induced Impairment of Intestinal Barrier Function

Shu Okugawa, Mahtab Moayeri, Michael A. Eckhaus, Devorah Crown, Sharmina Miller-Randolph, Shihui Liu, Shizuo Akira, Stephen H. Leppla

INFECTION AND IMMUNITY　Vol. 79　No. 1　p. 118-124　2011/01　Research paper (scientific journal)

Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity

Ya-Jen Chang, Hye Young Kim, Lee A. Albacker, Hyun Hee Lee, Nicole Baumgarth, Shizuo Akira, Paul B. Savage, Shin Endo, Takashi Yamamura, Janneke Maaskant, Naoki Kitano, Abel Singh, Apoorva Bhatt, Gurdyal S. Besra, Peter van den Elzen, Ben Appelmelk, Richard W. Franck, Guangwu Chen, Rosemarie H. DeKruyff, Michio Shimamura, Petr Illarionov, Dale T. Umetsu

JOURNAL OF CLINICAL INVESTIGATION　Vol. 121　No. 1　p. 57-69　2011/01　Research paper (scientific journal)

Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells

Mayumi Ueta, Taro Kawai, Norihiko Yokoi, Shizuo Akira, Shigeru Kinoshita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 404　No. 1　p. 419-423　2011/01　Research paper (scientific journal)

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

Sun Myung Joung, Zee-Yong Park, Shilpa Rani, Osamu Takeuchi, Shizuo Akira, Joo Young Lee

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 1　p. 499-507　2011/01　Research paper (scientific journal)

Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4(+) T Cells during Aspergillus fumigatus Antigen Exposure

Sara A. Paveglio, Jenna Allard, Samantha R. Foster Hodgkins, Jennifer L. Ather, Mieke Bevelander, Jana Mayette Campbell, Laurie A. Whittaker LeClair, Sean M. McCarthy, Albert van der Vliet, Benjamin T. Suratt, Jonathan E. Boyson, Satoshi Uematsu, Shizuo Akira, Matthew E. Poynter

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY　Vol. 44　No. 1　p. 11-23　2011/01　Research paper (scientific journal)

Pathogen recognition by the innate immune system

Himanshu Kumar, Taro Kawai, Shizuo Akira

International Reviews of Immunology　Vol. 30　No. 1　p. 16-34　2011/01　Research paper (scientific journal)

TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity

Shirdi E. Letran, Seung-Joo Lee, Shaikh M. Atif, Satoshi Uematsu, Shizuo Akira, Stephen J. McSorley

European Journal of Immunology　Vol. 41　No. 1　p. 29-38　2011/01　Research paper (scientific journal)

Crohn disease: A current perspective on genetics, autophagy and immunity

Thaddeus S. Stappenbeck, John D. Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes, Ramnik J. Xavier

Autophagy　Vol. 7　No. 4　p. 355-374　2011

Innate and adaptive immune responses to viral infection and vaccination

Taiki Aoshi, Shohei Koyama, Kouji Kobiyama, Shizuo Akira, Ken J Ishii

Current Opinion in Virology　Vol. 1　No. 4　p. 226-232　2011　Research paper (scientific journal)

Role of MyD88 and Toll-Like Receptors 2 and 4 in the Sensing of Parachlamydia acanthamoebae

Thierry Roger, Nicola Casson, Antony Croxatto, Jose Manuel Entenza, Marc Pusztaszeri, Shizuo Akira, Marlies Knaup Reymond, Didier Le Roy, Thierry Calandra, Gilbert Greub

INFECTION AND IMMUNITY　Vol. 78　No. 12　p. 5195-5201　2010/12　Research paper (scientific journal)

Role of Adrenomedullin in Lyme Disease

Meghan L. Marre, Courtney T. Darcy, Janeth Yinh, Shizuo Akira, Satoshi Uematsu, Allen C. Steere, Linden T. Hu

INFECTION AND IMMUNITY　Vol. 78　No. 12　p. 5307-5313　2010/12　Research paper (scientific journal)

MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection

Sang-Uk Seo, Hyung-Joon Kwon, Joo-Hye Song, Young-Ho Byun, Baik Lin Seong, Taro Kawai, Shizuo Akira, Mi-Na Kweon

JOURNAL OF VIROLOGY　Vol. 84　No. 24　p. 12713-12722　2010/12　Research paper (scientific journal)

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN-Beta Induction

Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno, Tsukasa Seya

PLOS ONE　Vol. 5　No. 12　2010/12　Research paper (scientific journal)

Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice

Ralph Burkhardt, Sue-Anne Toh, William R. Lagor, Andrew Birkeland, Michael Levin, Xiaoyu Li, Megan Robblee, Victor D. Fedorov, Masahiro Yamamoto, Takashi Satoh, Shizuo Akira, Sekar Kathiresan, Jan L. Breslow, Daniel J. Rader

Journal of Clinical Investigation　Vol. 120　No. 12　p. 4410-4414　2010/12/01　Research paper (scientific journal)

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

K. Hyakkoku, J. Hamanaka, K. Tsuruma, M. Shimazawa, H. Tanaka, S. Uematsu, S. Akira, N. Inagaki, H. Nagai, H. Hara

Neuroscience　Vol. 171　No. 1　p. 258-267　2010/11/24　Research paper (scientific journal)

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

Tetsuo Tsuchida, Jian Zou, Tatsuya Saitoh, Himanshu Kumar, Takayuki Abe, Yoshiharu Matsuura, Taro Kawai, Shizuo Akira

Immunity　Vol. 33　No. 5　p. 765-776　2010/11/24　Research paper (scientific journal)

Toll-Like Receptor 9 Enhances Nephritogenic Immunity and Glomerular Leukocyte Recruitment, Exacerbating Experimental Crescentic Glomerulonephritis

Shaun A. Summers, Oliver M. Steinmetz, Joshua D. Ooi, Poh-yi Gan, Kim M. O'Sullivan, Kumar Visvanathan, Shizuo Akira, A. Richard Kitching, Stephen R. Holdsworth

AMERICAN JOURNAL OF PATHOLOGY　Vol. 177　No. 5　p. 2234-2244　2010/11　Research paper (scientific journal)

Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers

Takako Ae, Takashi Ohno, Youichiro Hattori, Tatsunori Suzuki, Kanako Hosono, Tsutomu Minamino, Takehito Sato, Satoshi Uematsu, Shizuo Akira, Wasaburo Koizumi, Masataka Majima

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　Vol. 299　No. 5　p. G1139-G1146　2010/11　Research paper (scientific journal)

Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes (Retracted article. See vol. 32, pg. E22, 2012)

Yasuko Abe, Akio Kawakami, Mizuko Osaka, Satoshi Uematsu, Shizuo Akira, Kentaro Shimokado, Frank M. Sacks, Masayuki Yoshida

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 30　No. 11　p. 2242-U501　2010/11　Research paper (scientific journal)

Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling

Shuhei Hashiguchi, Yuya Yamaguchi, Osamu Takeuchi, Shizuo Akira, Kazuhisa Sugimura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 402　No. 1　p. 19-22　2010/11　Research paper (scientific journal)

Negative regulators in toll-like receptor responses

Shizuo Akira, Tatsuya Saitoh, Kazufumi Matsushita, Osamu Takeuchi

Cornea　Vol. 29　No. SUPPL. 1　p. S13-9　2010/11　Research paper (international conference proceedings)

Influenza A virus polymerase inhibits type I interferon induction by binding to interferon β promoter stimulator 1

Atsushi Iwai, Takuya Shiozaki, Taro Kawai, Shizuo Akira, Yoshihiro Kawaoka, Ayato Takada, Hiroshi Kida, Tadaaki Miyazakia

Journal of Biological Chemistry　Vol. 285　No. 42　p. 32064-32074　2010/10/15　Research paper (scientific journal)

IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

Tohru Miyake, Takashi Satoh, Hiroki Kato, Kazufumi Matsushita, Yutaro Kumagai, Alexis Vandenbon, Tohru Tani, Tatsushi Muta, Shizuo Akira, Osamu Takeuchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 107　No. 41　p. 17680-17685　2010/10/12　Research paper (scientific journal)

Induction of type I interferon by adenovirus-encoded small RNAs

Tomoko Yamaguchi, Kenji Kawabata, Emi Kouyama, Ken J. Ishii, Kazufumi Katayama, Takayuki Suzuki, Shinnosuke Kurachi, Fuminori Sakurai, Shizuo Akira, Hiroyuki Mizuguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 107　No. 40　p. 17286-17291　2010/10/05　Research paper (scientific journal)

Pathways Regulating Cytosolic Phospholipase A(2) Activation and Eicosanoid Production in Macrophages by Candida albicans

Saritha Suram, Todd A. Gangelhoff, Philip R. Taylor, Marcela Rosas, Gordon D. Brown, Joseph V. Bonventre, Shizuo Akira, Satoshi Uematsu, David L. Williams, Robert C. Murphy, Christina C. Leslie

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 40　p. 30676-30685　2010/10　Research paper (scientific journal)

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Takashi Satoh, Osamu Takeuchi, Alexis Vandenbon, Koubun Yasuda, Yoshiaki Tanaka, Yutaro Kumagai, Tohru Miyake, Kazufumi Matsushita, Toshihiko Okazaki, Tatsuya Saitoh, Kiri Honma, Toshifumi Matsuyama, Katsuyuki Yui, Tohru Tsujimura, Daron M. Standley, Kenji Nakanishi, Kenta Nakai, Shizuo Akira

Nature Immunology　Vol. 11　No. 10　p. 936-944　2010/10　Research paper (scientific journal)

E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

Koji Sayama, Masahiro Yamamoto, Yuji Shirakata, Yasushi Hanakawa, Satoshi Hirakawa, Xiuju Dai, Mikiko Tohyama, Sho Tokumaru, Myoung-Sook Shin, Hiroaki Sakurai, Shizuo Akira, Koji Hashimoto

Journal of Biological Chemistry　Vol. 285　No. 39　p. 30042-30049　2010/09/24　Research paper (scientific journal)

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.

Kei-ichiro Arimoto, Kenji Funami, Yasushi Saeki, Keiji Tanaka, Katsuya Okawa, Osamu Takeuchi, Shizuo Akira, Yoshiki Murakami, Kunitada Shimotohno

Proceedings of the National Academy of Sciences of the United States of America　Vol. 107　No. 36　p. 15856-61　2010/09/07　Research paper (scientific journal)

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

Kohichi Matsunaga, Eiji Morita, Tatsuya Saitoh, Shizuo Akira, Nicholas T. Ktistakis, Tetsuro Izumi, Takeshi Noda, Tamotsu Yoshimori

Journal of Cell Biology　Vol. 190　No. 4　p. 511-521　2010/08/23　Research paper (scientific journal)

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair

Keigo Machida, Hidekazu Tsukamoto, Jian-Chang Liu, Yuan-Ping Han, Sugantha Govindarajan, Michael M. C. Lai, Shizuo Akira, Jing-Hsiung James Ou

Hepatology　Vol. 52　No. 2　p. 480-492　2010/08　Research paper (scientific journal)

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

Desiree A. Anthony, Daniel M. Andrews, Melvyn Chow, Sally V. Watt, Colin House, Shizuo Akira, Phillip I. Bird, Joseph A. Trapani, Mark J. Smyth

JOURNAL OF IMMUNOLOGY　Vol. 185　No. 3　p. 1794-1803　2010/08　Research paper (scientific journal)

Control of adipose tissue inflammation through TRB1

Anke Ostertag, Allan Jones, Adam J. Rose, Maria Liebert, Stefan Kleinsorg, Anja Reimann, Alexandros Vegiopoulos, Mauricio Berriel Diaz, Daniela Strzoda, Masahiro Yamamoto, Takashi Satoh, Shizuo Akira, Stephan Herzig

Diabetes　Vol. 59　No. 8　p. 1991-2000　2010/08　Research paper (scientific journal)

The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells

Behnaz Shokouhi, Cevayir Coban, Vasif Hasirci, Erkin Aydin, Anandhan Dhanasingh, Nian Shi, Shohei Koyama, Shizuo Akira, Martin Zenke, Antonio S. Sechi

Biomaterials　Vol. 31　No. 22　p. 5759-5771　2010/08　Research paper (scientific journal)

Systemic Toll-Like Receptor Stimulation Suppresses Experimental Allergic Asthma and Autoimmune Diabetes in NOD Mice

Aude Aumeunier, Francoise Grela, Abdulraouf Ramadan, Linh Pham Van, Emilie Bardel, Alejandro Gomez Alcala, Pascale Jeannin, Shizuo Akira, Jean-Francois Bach, Nathalie Thieblemont

PLOS ONE　Vol. 5　No. 7　2010/07　Research paper (scientific journal)

Telomere-Mediated Chromosomal Instability Triggers TLR4 Induced Inflammation and Death in Mice

Rabindra N. Bhattacharjee, Birendranath Banerjee, Shizuo Akira, M. Prakash Hande

PLOS ONE　Vol. 5　No. 7　2010/07　Research paper (scientific journal)

A novel in vivo inducible dendritic cell ablation model in mice.

Okuyama M, Kayama H, Atarashi K, Saiga H, Kimura T, Waisman A, Yamamoto M, Takeda K

Biochem Biophys Res Commun. 　Vol. 397　No. 3　p. 559-563　2010/07

MPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice

Hiroki Kamata, Kanako Hosono, Tatsunori Suzuki, Yasufumi Ogawa, Hidefumi Kubo, Hiroshi Katoh, Yoshiya Ito, Satoshi Uematsu, Shizuo Akira, Masahiko Watanabe, Masataka Majima

Biomedicine and Pharmacotherapy　Vol. 64　No. 6　p. 409-416　2010/07　Research paper (scientific journal)

TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

Cevayir Coban, Toshihiro Horii, Shizuo Akira, Ken J Ishii

Expert Review of Vaccines　Vol. 9　No. 7　p. 775-784　2010/07

Regulation of innate immune responses by autophagy-related proteins

Tatsuya Saitoh, Shizuo Akira

Journal of Cell Biology　Vol. 189　No. 6　p. 925-935　2010/06/14　Research paper (scientific journal)

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

Huan Yang, Hulda S. Hreggvidsdottir, Karin Palmblad, Haichao Wang, Mahendar Ochani, Jianhua Li, Ben Lu, Sangeeta Chavan, Mauricio Rosas-Ballina, Yousef Al-Abed, Shizuo Akira, Angelika Bierhaus, Helena Erlandsson-Harris, Ulf Andersson, Kevin J. Tracey

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 107　No. 26　p. 11942-11947　2010/06　Research paper (scientific journal)

Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

Zi-jian Pan, Shannon Maier, Karen Schwarz, Jennifer Azbill, Shizuo Akira, Satoshi Uematsu, A. Darise Farris

ANNALS OF THE RHEUMATIC DISEASES　Vol. 69　No. 6　p. 1195-1199　2010/06　Research paper (scientific journal)

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

Marie-Laure Santiago-Raber, Isabelle Dunand-Sauthier, Tianfu Wu, Quan-Zhen Li, Satoshi Uematsu, Shizuo Akira, Walter Reith, Chandra Mohan, Brian L. Kotzin, Shozo Izui

JOURNAL OF AUTOIMMUNITY　Vol. 34　No. 4　p. 339-348　2010/06　Research paper (scientific journal)

Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.

Shinobu Saijo, Satoshi Ikeda, Keiko Yamabe, Shigeru Kakuta, Harumichi Ishigame, Aoi Akitsu, Noriyuki Fujikado, Toshimasa Kusaka, Sachiko Kubo, Soo-hyun Chung, Ryohei Komatsu, Noriko Miura, Yoshiyuki Adachi, Naohito Ohno, Kazutoshi Shibuya, Natsuo Yamamoto, Kazuyoshi Kawakami, Sho Yamasaki, Takashi Saito, Shizuo Akira, Yoichiro Iwakura

Immunity　Vol. 32　No. 5　p. 681-91　2010/05/28　Research paper (scientific journal)

自然免疫における臨床展望

三宅 亨, 竹内 理, 審良 静男

Medical Practice　Vol. 27　No. 5　p. 876-878　2010/05

TAK1 Suppresses a NEMO-Dependent but NF-kappa B-Independent Pathway to Liver Cancer

Kira Bettermann, Mihael Vucur, Johannes Haybaeck, Christiane Koppe, Joern Janssen, Felix Heymann, Achim Weber, Ralf Weiskirchen, Christian Liedtke, Nikolaus Gassler, Michael Mueller, Rita de Vos, Monika Julia Wolf, Yannick Boege, Gitta Maria Seleznik, Nicolas Zeller, Daniel Erny, Thomas Fuchs, Stefan Zoller, Stefano Cairo, Marie-Annick Buendia, Marco Prinz, Shizuo Akira, Frank Tacke, Mathias Heikenwalder, Christian Trautwein, Tom Luedde

CANCER CELL　Vol. 17　No. 5　p. 481-496　2010/05　Research paper (scientific journal)

Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis

Daniel J. Fong, Cory M. Hogaboam, Yosuke Matsuno, Shizuo Akira, Satoshi Uematsu, Amrita D. Joshi

IMMUNOLOGY　Vol. 130　No. 1　p. 125-136　2010/05　Research paper (scientific journal)

Human lactoferrin activates NF-kappa B through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

Ken Ando, Keiichi Hasegawa, Ken-ichi Shindo, Tomoyasu Furusawa, Tomofumi Fujino, Kiyomi Kikugawa, Hiroyasu Nakano, Osamu Takeuchi, Shizuo Akira, Taishin Akiyama, Jin Gohda, Jun-ichiro Inoue, Makio Hayakawa

FEBS JOURNAL　Vol. 277　No. 9　p. 2051-2066　2010/05　Research paper (scientific journal)

Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity

Oliver Schulz, Andreas Pichlmair, Jan Rehwinkel, Neil C. Rogers, Donalyn Scheuner, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Randal J. Kaufman, Caetano Reis e Sousa

CELL HOST & MICROBE　Vol. 7　No. 5　p. 354-361　2010/05　Research paper (scientific journal)

The role of pattern-recognition receptors in innate immunity: Update on toll-like receptors

Taro Kawai, Shizuo Akira

Nature Immunology　Vol. 11　No. 5　p. 373-384　2010/05

Identification and functions of pattern-recognition receptors

Yutaro Kumagai, Shizuo Akira

Journal of Allergy and Clinical Immunology　Vol. 125　No. 5　p. 985-992　2010/05　Research paper (scientific journal)

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-κB signaling

Claudia Toma, Naomi Higa, Yukiko Koizumi, Noboru Nakasone, Yasunori Ogura, Andrea J. McCoy, Luigi Franchi, Satoshi Uematsu, Junji Sagara, Shun'ichiro Taniguchi, Hiroko Tsutsui, Shizuo Akira, Jürg Tschopp, Gabriel Núñez, Toshihiko Suzuki

Journal of Immunology　Vol. 184　No. 9　p. 5287-5297　2010/05/01　Research paper (scientific journal)

IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.

Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Muta T, Takayanagi H

Nature　Vol. 464　No. 7293　p. 1381-1385　2010/04　Research paper (scientific journal)

Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.

Shohei Koyama, Taiki Aoshi, Takeshi Tanimoto, Yutaro Kumagai, Kouji Kobiyama, Takahiro Tougan, Kazuo Sakurai, Cevayir Coban, Toshihiro Horii, Shizuo Akira, Ken J Ishii

Science translational medicine　Vol. 2　No. 25　2010/03/31　Research paper (scientific journal)

Microsomal prostaglandin e synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

Y. Ikeda-Matsuo, Y. Hirayama, A. Ota, S. Uematsu, S. Akira, Y. Sasaki

British Journal of Pharmacology　Vol. 159　No. 5　p. 1174-1186　2010/03　Research paper (scientific journal)

Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

Deepa Rajagopal, Carine Paturel, Yannis Morel, Satoshi Uematsu, Shizuo Akira, Sandra S. Diebold

BLOOD　Vol. 115　No. 10　p. 1949-1957　2010/03　Research paper (scientific journal)

Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling

Philip O. Scumpia, Kindra M. Kelly-Scumpia, Matthew J. Delano, Jason S. Weinstein, Alex G. Cuenca, Samer Al-Quran, Ian Bovio, Shizuo Akira, Yutaro Kumagai, Lyle L. Moldawer

JOURNAL OF IMMUNOLOGY　Vol. 184　No. 5　p. 2247-2251　2010/03　Research paper (scientific journal)

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi, Shizuo Akira

Cell　Vol. 140　No. 6　p. 805-820　2010/03

Intracellular mycobacterium avium intersect transferrin in the Rab11 + recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway

Øyvind Halaas, Magnus Steigedal, Markus Haug, Jane A. Awuh, Liv Ryan, Andreas Brech, Shintaro Sato, Harald Husebye, Gerard A. Cangelosi, Shizuo Akira, Roland K. Strong, Terje Espevik, Trude H. Flo

Journal of Infectious Diseases　Vol. 201　No. 5　p. 783-792　2010/03/01　Research paper (scientific journal)

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

Thornik Reimer, Michael H. Shaw, Luigi Franchi, Cevayir Coban, Ken J. Ishii, Shizuo Akira, Toshihiro Horii, Ana Rodriguez, Gabriel Núñez

European Journal of Immunology　Vol. 40　No. 3　p. 764-769　2010/03　Research paper (scientific journal)

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells

Christian A. Luber, Juergen Cox, Henning Lauterbach, Ben Fancke, Matthias Selbach, Jurg Tschopp, Shizuo Akira, Marian Wiegand, Hubertus Hochrein, Meredith O'Keeffe, Matthias Mann

IMMUNITY　Vol. 32　No. 2　p. 279-289　2010/02　Research paper (scientific journal)

Endothelial Microsomal Prostaglandin E Synthase-1 Exacerbates Neuronal Loss Induced by Kainate

Takako Takemiya, Kiyoshi Matsumura, Hiroko Sugiura, Michiyo Maehara, Shin Yasuda, Satoshi Uematsu, Shizuo Akira, Kanato Yamagata

JOURNAL OF NEUROSCIENCE RESEARCH　Vol. 88　No. 2　p. 381-390　2010/02　Research paper (scientific journal)

TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection

Elia Burns, Tal Eliyahu, Satoshi Uematsu, Shizuo Akira, Gabriel Nussbaum

JOURNAL OF IMMUNOLOGY　Vol. 184　No. 3　p. 1455-1462　2010/02　Research paper (scientific journal)

Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9

Cevayir Coban, Yoshikatsu Igari, Masanori Yagi, Thornik Reimer, Shohei Koyama, Taiki Aoshi, Keiichi Ohata, Toshihiro Tsukui, Fumihiko Takeshita, Kazuo Sakurai, Takahisa Ikegami, Atsushi Nakagawa, Toshihiro Horii, Gabriel Nuñez, Ken J. Ishii, Shizuo Akira

Cell Host and Microbe　Vol. 7　No. 1　p. 50-61　2010/01/21　Research paper (scientific journal)

Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

Tomokazu Matsuda, Yoshiaki Kido, Shun-Ichiro Asahara, Tsuneyasu Kaisho, Takashi Tanaka, Naoko Hashimoto, Yutaka Shigeyama, Akihiko Takeda, Tae Inoue, Yuki Shibutani, Maki Koyanagi, Tetsuya Hosooka, Michihiro Matsumoto, Hiroshi Inoue, Tohru Uchida, Masato Koike, Yasuo Uchiyama, Shizuo Akira, Masato Kasuga

Journal of Clinical Investigation　Vol. 120　No. 1　p. 115-126　2010/01/04　Research paper (scientific journal)

Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice

Toru Hosoi, Shota Yokoyama, Suguru Matsuo, Shizuo Akira, Koichiro Ozawa

PLoS ONE　Vol. 5　No. 9　p. 1-7　2010　Research paper (scientific journal)

Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

Peter Broglie, Kunihiro Matsumoto, Shizuo Akira, David L. Brautigan, Jun Ninomiya-Tsuji

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 285　No. 4　p. 2333-2339　2010/01　Research paper (scientific journal)

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

Hendrik Poeck, Michael Bscheider, Olaf Gross, Katrin Finger, Susanne Roth, Manuele Rebsamen, Nicole Hannesschlaeger, Martin Schlee, Simon Rothenfusser, Winfried Barchet, Hiroki Kato, Shizuo Akira, Satoshi Inoue, Stefan Endres, Christian Peschel, Gunther Hartmann, Veit Hornung, Juergen Ruland

NATURE IMMUNOLOGY　Vol. 11　No. 1　p. 63-1824　2010/01　Research paper (scientific journal)

Prostaglandin E-2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation

Anders Lundequist, Samridhi N. Nallamshetty, Wei Xing, Chunli Feng, Tanya M. Laidlaw, Satoshi Uematsu, Shizuo Akira, Joshua A. Boyce

JOURNAL OF IMMUNOLOGY　Vol. 184　No. 1　p. 433-441　2010/01　Research paper (scientific journal)

Microsomal prostaglandin e synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors

Y. Ikeda-Matsuo, H. Tanji, A. Ota, Y. Hirayama, S. Uematsu, S. Akira, Y. Sasaki

British Journal of Pharmacology　Vol. 160　No. 4　p. 847-859　2010　Research paper (scientific journal)

Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway.

Gang Xiao, Akiko Miyazato, Yuzuru Abe, Tiantuo Zhang, Kiwamu Nakamura, Ken Inden, Misuzu Tanaka, Daiki Tanno, Tomomitsu Miyasaka, Keiko Ishii, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Natsuo Yamamoto, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku, Kazuyoshi Kawakami

Cellular immunology　Vol. 263　No. 2　p. 241-50　2010　Research paper (scientific journal)

Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis And Anagen Induction Shown By Using Keratinocyte-Specific TAK1-Deficient Mice

Koji Sayama, Kentaro Kajiya, Koji Sugawara, Shintaro Sato, Satoshi Hirakawa, Yuji Shirakata, Yasushi Hanakawa, Xiuju Dai, Yumiko Ishimatsu-Tsuji, Daniel Metzger, Pierre Chambon, Shizuo Akira, Ralf Paus, Jiro Kishimoto, Koji Hashimoto

PLoS ONE　Vol. 5　No. 6　p. e11275-9　2010　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

Daisuke Kamei, Makoto Murakami, Yuka Sasaki, Yoshihito Nakatani, Masataka Majima, Yukio Ishikawa, Toshiharu Ishi, Satoshi Uematsu, Shizuo Akira, Shuntaro Hara, Ichiro Kudo

Biochemical Journal　Vol. 425　No. 2　p. 361-371　2010　Research paper (scientific journal)

The malarial metabolite hemozoin and its potential use as a vaccine adjuvant

Cevayir Coban, Masanori Yagi, Keiichi Ohata, Yoshikatsu Igari, Toshihiro Tsukui, Toshihiro Horii, Ken J Ishii, Shizuo Akira

Allergology International　Vol. 59　No. 2　p. 115-124　2010

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

Michael Berger, Philippe Krebs, Karine Crozat, Xiaohong Li, Ben A. Croker, Owen M. Siggs, Daniel Popkin, Xin Du, Brian R. Lawson, Argyrios N. Theofilopoulos, Yu Xia, Kevin Khovananth, Eva Marie Y. Moresco, Takashi Satoh, Osamu Takeuchi, Shizuo Akira, Bruce Beutler

Nature Immunology　Vol. 11　No. 4　p. 335-343　2010　Research paper (scientific journal)

Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal β-glucan

Himanshu Kumar, Yutaro Kumagai, Tetsuo Tsuchida, Paul A. Koenig, Takashi Satoh, Zijin Guo, Myoung Ho Jang, Tatsuya Saitoh, Shizuo Akira, Taro Kawai

Journal of Immunology　Vol. 183　No. 12　p. 8061-8067　2009/12/15　Research paper (scientific journal)

Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13

Xuefeng Wu, Masahiro Yamamoto, Shizuo Akira, Shao-Cong Sun

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 49　p. 20836-20841　2009/12/08　Research paper (scientific journal)

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Tatsuya Saitoh, Naonobu Fujita, Takuya Hayashi, Keigo Takahara, Takashi Satoh, Hanna Lee, Kohichi Matsunaga, Shun Kageyama, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Taro Kawai, Ken Ishii, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 49　p. 20842-20846　2009/12/08　Research paper (scientific journal)

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

Melanie L. Conrad, Ruth Ferstl, Rene Teich, Stephanie Brand, Nicole Bluemer, Ali Oe. Yildirim, Cecilia C. Patrascan, Anna Hanuszkiewicz, Shizuo Akira, Hermann Wagner, Otto Holst, Erika von Mutius, Petra I. Pfefferle, Carsten J. Kirschning, Holger Garn, Harald Renz

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 206　No. 13　p. 2869-2877　2009/12　Research paper (scientific journal)

Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearance

Suzanne Talbot, Sabine Toetemeyer, Masahiro Yamamoto, Shizuo Akira, Katherine Hughes, David Gray, Tom Barr, Pietro Mastroeni, Duncan J. Maskell, Clare E. Bryant

IMMUNOLOGY　Vol. 128　No. 4　p. 472-483　2009/12　Research paper (scientific journal)

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

Yasuyuki Kihara, Takuya Matsushita, Yoshihiro Kita, Satoshi Uematsu, Shizuo Akira, Jun-ichi Kira, Satoshi Ishii, Takao Shimizu

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 106　No. 51　p. 21807-21812　2009/12　Research paper (scientific journal)

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 206　No. 13　p. 2879-2888　2009/12　Research paper (scientific journal)

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

Yoshida Ryoko, Takaesu Giichi, Yoshida Hideyuki, Okamoto Fuyuki, Yoshioka Tomoko, Choi Yongwon, Akira Shizuo, Kawai Taro, Yoshimura Akihiko, Kobayashi Takashi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 52　2009/12　Research paper (scientific journal)

Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts.

Naonobu Fujita, Tatsuya Saitoh, Shun Kageyama, Shizuo Akira, Takeshi Noda, Tamotsu Yoshimori

The Journal of biological chemistry　Vol. 284　No. 47　p. 32602-9　2009/11/20　Research paper (scientific journal)

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Hideyuki Yanai, Tatsuma Ban, ZhiChao Wang, Myoung Kwon Choi, Takeshi Kawamura, Hideo Negishi, Makoto Nakasato, Yan Lu, Sho Hangai, Ryuji Koshiba, David Savitsky, Lorenza Ronfani, Shizuo Akira, Marco E. Bianchi, Kenya Honda, Tomohiko Tamura, Tatsuhiko Kodama, Tadatsugu Taniguchi

NATURE　Vol. 462　No. 7269　p. 99-U110　2009/11　Research paper (scientific journal)

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation

Pui Y. Lee, Yi Li, Yutaro Kumagai, Yuan Xu, Jason S. Weinstein, Erinn S. Kellner, Dina G. Nacionales, Edward J. Butfiloski, Nico van Rooijen, Shizuo Akira, Eric S. Sobel, Minoru Satoh, Westley H. Reeves

AMERICAN JOURNAL OF PATHOLOGY　Vol. 175　No. 5　p. 2023-2033　2009/11　Research paper (scientific journal)

[Regulation of allergy by innate immune system].

Kumagai Y, Akira S

Nihon rinsho. Japanese journal of clinical medicine　Vol. 67　No. 11　p. 2055-2061　2009/11

Control of inflammatory responses by a novel RNase, Zc3h12a

Osamu Takeuchi, Kazufumi Matsushita, Shizuo Akira

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 54　No. 14　p. 1837-1841　2009/11

Toll-like receptors and innate immunity

Himanshu Kumar, Taro Kawai, Shizuo Akira

Biochemical and Biophysical Research Communications　Vol. 388　No. 4　p. 621-625　2009/10/30

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection

Laura Papon, Alexandra Oteiza, Tadaatsu Imaizumi, Hiroki Kato, Emiliana Brocchi, T. Glen Lawson, Shizuo Akira, Nadir Mechti

Virology　Vol. 393　No. 2　p. 311-318　2009/10/25　Research paper (scientific journal)

Two mechanistically and temporally distinct NF-κB activation pathways in IL-1 signaling

Kohsuke Yamazaki, Jin Gohda, Atsuhiro Kanayama, Yusei Miyamoto, Hiroaki Sakurai, Masahiro Yamamoto, Shizuo Akira, Hidetoshi Hayashi, Bing Su, Jun-Ichiro Inoue

Science Signaling　Vol. 2　No. 93　2009/10/20　Research paper (scientific journal)

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

Manfred Nairz, Igor Theurl, Andrea Schroll, Milan Theurl, Gernot Fritsche, Ewald Lindner, Markus Seifert, Marie-Laure V. Crouch, Klaus Hantke, Shizuo Akira, Ferric C. Fang, Guenter Weiss

BLOOD　Vol. 114　No. 17　p. 3642-3651　2009/10　Research paper (scientific journal)

Two Mechanistically and Temporally Distinct NF-kappa B Activation Pathways in IL-1 Signaling

Kohsuke Yamazaki, Jin Gohda, Atsuhiro Kanayama, Yusei Miyamoto, Hiroaki Sakurai, Masahiro Yamamoto, Shizuo Akira, Hidetoshi Hayashi, Bing Su, Jun-Ichiro Inoue

SCIENCE SIGNALING　Vol. 2　No. 93　2009/10　Research paper (scientific journal)

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

Andreas Pichlmair, Oliver Schulz, Choon-Ping Tan, Jan Rehwinkel, Hiroki Kato, Osamu Takeuchi, Shizuo Akira, Michael Way, Giampietro Schiavo, Caetano Reis e Sousa

JOURNAL OF VIROLOGY　Vol. 83　No. 20　p. 10761-10769　2009/10　Research paper (scientific journal)

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA

Myoung Kwon Choi, ZhiChao Wang, Tatsuma Ban, Hideyuki Yanai, Yan Lu, Ryuji Koshiba, Yukana Nakaima, Sho Hangai, David Savitsky, Makoto Nakasato, Hideo Negishi, Osamu Takeuchi, Kenya Honda, Shizuo Akira, Tomohiko Tamura, Tadatsugu Taniguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 106　No. 42　p. 17870-17875　2009/10　Research paper (scientific journal)

Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

Kei Yasuda, Christophe Richez, Melissa B. Uccellini, Rocco J. Richards, Ramon G. Bonegio, Shizuo Akira, Marc Monestier, Ronald B. Corley, Gregory A. Viglianti, Ann Marshak-Rothstein, Ian R. Rifkin

JOURNAL OF IMMUNOLOGY　Vol. 183　No. 5　p. 3109-3117　2009/09　Research paper (scientific journal)

Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity

Tomohiro Kubo, Yuki Uchida, Yuko Watanabe, Masahiro Abe, Akira Nakamura, Masao Ono, Shizuo Akira, Toshiyuki Takai

Journal of Experimental Medicine　Vol. 206　No. 9　p. 1971-1982　2009/08/31　Research paper (scientific journal)

Poly I:C-induced activation of NK cells by CD8α⁺ dendritic cells via the IPS-1 and TRIF-dependent pathways

Tohru Miyake, Yutaro Kumagai, Hiroki Kato, Zijin Guo, Kazufumi Matsushita, Takashi Satoh, Tatsukata Kawagoe, Himanshu Kumar, Myoung Ho Jang, Taro Kawai, Tohru Tani, Osamu Takeuchi, Shizuo Akira

Journal of Immunology　Vol. 183　No. 4　p. 2522-2528　2009/08/15　Research paper (scientific journal)

Lipopolysaccharide Inhibition of Glucose Production Through the Toll-Like Receptor-4, Myeloid Differentiation Factor 88, and Nuclear Factor kappa B Pathway

Carl F. Raetzsch, Natasha L. Brooks, J. McKee Alderman, Kelli S. Moore, Peter A. Hosick, Simon Klebanov, Shizuo Akira, James E. Bear, Albert S. Baldwin, Nigel Mackman, Terry P. Combs

HEPATOLOGY　Vol. 50　No. 2　p. 592-600　2009/08　Research paper (scientific journal)

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, Russell E. Vance

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 206　No. 9　p. 1899-1911　2009/08　Research paper (scientific journal)

Innate immune control of nucleic acid-based vaccine immunogenicity

Shohei Koyama, Cevayir Coban, Taiki Aoshi, Toshihiro Horii, Shizuo Akira, Ken J. Ishii

Expert Review of Vaccines　Vol. 8　No. 8　p. 1099-1107　2009/08

Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner

Takayuki Abe, Yuuki Kaname, Xiaoyu Wen, Hideki Tani, Kohji Moriishi, Satoshi Uematsu, Osamu Takeuchi, Ken J. Ishii, Taro Kawai, Shizuo Akira, Yoshiharu Matsuura

Journal of Virology　Vol. 83　No. 15　p. 7629-7640　2009/08　Research paper (scientific journal)

Intestine and Innate Immunity

UEMATSU Satoshi, AKIRA Shizuo

Bioscience of Microbiota, Food and Health　Vol. 28　No. 3　p. 69-74　2009/07/01

Polyl:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation

Inigo Tirapu, Benoit Giquel, Lena Alexopoulou, Satoshi Uematsu, Richard Flavell, Shizuo Akira, Sandra S. Diebold

INTERNATIONAL IMMUNOLOGY　Vol. 21　No. 7　p. 871-879　2009/07　Research paper (scientific journal)

Downstream Signals for MyD88-Mediated Phagocytosis of Borrelia burgdorferi Can Be Initiated by TRIF and Are Dependent on PI3K

Ok S. Shin, Lloyd S. Miller, Robert L. Modlin, Shizuo Akira, Satoshi Uematsu, Linden T. Hu

JOURNAL OF IMMUNOLOGY　Vol. 183　No. 1　p. 491-498　2009/07　Research paper (scientific journal)

Recognition of 5 ' Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Martin Schlee, Andreas Roth, Veit Hornung, Cristina Amparo Hagmann, Vera Wimmenauer, Winfried Barchet, Christoph Coch, Markus Janke, Aleksandra Mihailovic, Greg Wardle, Stefan Juranek, Hiroki Kato, Taro Kawai, Hendrik Poeck, Katherine A. Fitzgerald, Osamu Takeuchi, Shizuo Akira, Thomas Tuschl, Eicke Latz, Janos Ludwig, Gunther Hartmann

IMMUNITY　Vol. 31　No. 1　p. 25-34　2009/07　Research paper (scientific journal)

Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans.

Akiko Miyazato, Kiwamu Nakamura, Natsuo Yamamoto, Héctor M Mora-Montes, Misuzu Tanaka, Yuzuru Abe, Daiki Tanno, Ken Inden, Xiao Gang, Keiko Ishii, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Kotaro Mitsutake, Neil A R Gow, Mitsuo Kaku, Kazuyoshi Kawakami

Infection and immunity　Vol. 77　No. 7　p. 3056-64　2009/07　Research paper (scientific journal)

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.

Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

PLoS pathogens　Vol. 5　No. 7　2009/07　Research paper (scientific journal)

Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin

John T. Bates, Satoshi Uematsu, Shizuo Akira, Steven B. Mizel

Journal of Immunology　Vol. 182　No. 12　p. 7539-7547　2009/06/15　Research paper (scientific journal)

【感染現象 その理解の深化から疾患制御への展望】生体防御機構研究の新展開 DNAワクチンの作用機序

小山 正平, 河越 龍方, 審良 静男, 石井 健

蛋白質・核酸・酵素　Vol. 54　No. 8　p. 1096-1100　2009/06

Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus

Sybille Kenzel, Sandra Santos-Sierra, Sachin D. Deshmukh, Inga Moeller, Bilge Ergin, Katherine A. Fitzgerald, Egil Lien, Shizuo Akira, Douglas T. Golenbock, Philipp Henneke

Infection and Immunity　Vol. 77　No. 6　p. 2474-2481　2009/06　Research paper (scientific journal)

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

Giuseppe Mancuso, Maria Gambuzza, Angelina Midiri, Carmelo Biondo, Salvatore Papasergi, Shizuo Akira, Giuseppe Teti, Concetta Beninati

NATURE IMMUNOLOGY　Vol. 10　No. 6　p. 587-U48　2009/06　Research paper (scientific journal)

Differential Role for c-Rel and C/EBP beta/delta in TLR-Mediated Induction of Proinflammatory Cytokines

Yong-Chen Lu, Ira Kim, Elizabeth Lye, Fang Shen, Nobutaka Suzuki, Shinobu Suzuki, Steve Gerondakis, Shizuo Akira, Sarah L. Gaffen, Wen-Chen Yeh, Pamela S. Ohashi

JOURNAL OF IMMUNOLOGY　Vol. 182　No. 11　p. 7212-7221　2009/06　Research paper (scientific journal)

iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

Carl De Trez, Stefan Magez, Shizuo Akira, Bernhard Ryffel, Yves Carlier, Eric Muraille

PLOS PATHOGENS　Vol. 5　No. 6　2009/06　Research paper (scientific journal)

Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

Julie Delaloye, Thierry Roger, Quynh-Giao Steiner-Tardivel, Didier Le Roy, Marlies Knaup Reymond, Shizuo Akira, Virginie Petrilli, Carmen E. Gomez, Beatriz Perdiguero, Juerg Tschopp, Giuseppe Pantaleo, Mariano Esteban, Thierry Calandra

PLOS PATHOGENS　Vol. 5　No. 6　2009/06　Research paper (scientific journal)

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

Laure Janot, Jean-Claude Sirard, Thomas Secher, Nicolas Noulin, Lizette Fick, Shizuo Akira, Satoshi Uematsu, Arnaud Didierlaurent, Tracy Hussell, Bernhard Ryffel, Francois Erard

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 39　No. 6　p. 1587-1596　2009/06　Research paper (scientific journal)

[Regulation of inflammation by autophagy].

Saitoh T, Naonobu F, Yoshimori T, Akira S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 54　No. 8 Suppl　p. 1119-1124　2009/06　Research paper (scientific journal)

Pathogen recognition in the innate immune response

Himanshu Kumar, Taro Kawai, Shizuo Akira

Biochemical Journal　Vol. 420　No. 1　p. 1-16　2009/05/15

TRAF6 Establishes Innate Immune Responses by Activating NF-kappa B and IRF7 upon Sensing Cytosolic Viral RNA and DNA

Hiroyasu Konno, Takuya Yamamoto, Kohsuke Yamazaki, Jin Gohda, Taishin Akiyama, Kentaro Semba, Hideo Goto, Atsushi Kato, Toshiaki Yujiri, Takahiko Imai, Yasushi Kawaguchi, Bing Su, Osamu Takeuchi, Shizuo Akira, Yasuko Tsunetsugu-Yokota, Jun-ichiro Inoue

PLOS ONE　Vol. 4　No. 5　2009/05　Research paper (scientific journal)

Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis

Mayumi Ueta, Satoshi Uematsu, Shizuo Akira, Shigeru Kinoshita

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY　Vol. 123　No. 5　p. 1187-1189　2009/05

Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif

Julia Lichtnekert, Volker Vielhauer, Daniel Zecher, Onkar P. Kulkarni, Sebastian Clauss, Stephan Segerer, Veit Hornung, Tanya N. Mayadas, Bruce Beutler, Shizuo Akira, Hans-Joachim Anders

American Journal of Physiology - Renal Physiology　Vol. 296　No. 4　p. F867-F874　2009/04　Research paper (scientific journal)

Ncf1 Provides a Reactive Oxygen Species-Independent Negative Feedback Regulation of TLR9-Induced IL-12p70 in Murine Dendritic Cells

Cornelia Richter, Martina Herrero San Juan, Jutta Will, Ralf P. Brandes, Ulrich Kalinke, Shizuo Akira, Josef M. Pfeilsehifter, Malin Hultqvist, Rikard Holmdahl, Heinfried H. Radeke

JOURNAL OF IMMUNOLOGY　Vol. 182　No. 7　p. 4183-4191　2009/04　Research paper (scientific journal)

Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production

Yumiko Tsukamoto, Yoshinori Nagai, Ai Kariyone, Takuma Shibata, Tsuneyasu Kaisho, Shizuo Akira, Kensuke Miyake, Kiyoshi Takatsua

MOLECULAR IMMUNOLOGY　Vol. 46　No. 7　p. 1278-1288　2009/04　Research paper (scientific journal)

Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif

Julia Lichtnekert, Volker Vielhauer, Daniel Zecher, Onkar P. Kulkarni, Sebastian Clauss, Stephan Segerer, Veit Hornung, Tanya N. Mayadas, Bruce Beutler, Shizuo Akira, Hans-Joachim Anders

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　Vol. 296　No. 4　p. F867-F874　2009/04　Research paper (scientific journal)

Toll-Like Receptor 2 Deficiency Is Associated with Enhanced Severity of Group B Streptococcal Disease

Manuela Puliti, Satoshi Uematsu, Shizuo Akira, Francesco Bistoni, Luciana Tissi

INFECTION AND IMMUNITY　Vol. 77　No. 4　p. 1524-1531　2009/04　Research paper (scientific journal)

Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis

Eyal Amiel, Anselmo Alonso, Satoshi Uematsu, Shizuo Akira, Matthew E. Poynter, Brent Berwin

JOURNAL OF LEUKOCYTE BIOLOGY　Vol. 85　No. 4　p. 595-605　2009/04　Research paper (scientific journal)

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

Kazufumi Matsushita, Osamu Takeuchi, Daron M. Standley, Yutaro Kumagai, Tatsukata Kawagoe, Tohru Miyake, Takashi Satoh, Hiroki Kato, Tohru Tsujimura, Haruki Nakamura, Shizuo Akira

Nature　Vol. 458　No. 7242　p. 1185-1190　2009/04　Research paper (scientific journal)

Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-α production in plasmacytoid dendritic cells

Yutaro Kumagai, Himanshu Kumar, Shohei Koyama, Taro Kawai, Osamu Takeuchi, Shizuo Akira

Journal of Immunology　Vol. 182　No. 7　p. 3960-3964　2009/04　Research paper (scientific journal)

Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages

Masa Tsuchiya, Vincent Piras, Sangdun Choi, Shizuo Akira, Masaru Tomita, Alessandro Giuliani, Kumar Selvarajoo

PLoS ONE　Vol. 4　No. 3　2009/03/20　Research paper (scientific journal)

TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and-independent humoral immune responses

Takashi Kobayashi, Tae Soo Kim, Anand Jacob, Matthew C. Walsh, Yuho Kadono, Ezequiel Fuentes-Pananá, Tomoko Yoshioka, Akihiko Yoshimura, Masahiro Yamamoto, Tsuneyasu Kaisho, Shizuo Akira, John G. Monroe, Yongwon Choi

PLoS ONE　Vol. 4　No. 3　2009/03/09　Research paper (scientific journal)

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

Marieke A. D. van Zoelen, Huan Yang, Sandrine Florquin, Joost C. M. Meijers, Shizuo Akira, Bernd Arnold, Peter P. Nawroth, Angelika Bierhaus, Kevin J. Tracey, Tom van der Poll

SHOCK　Vol. 31　No. 3　p. 280-284　2009/03　Research paper (scientific journal)

Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products

Jenna B. Allard, Lisa Rinaldi, Matthew J. Wargo, Gilman Allen, Shizuo Akira, Satoshi Uematsu, Matthew E. Poynter, Deborah A. Hogan, Mercedes Rincon, Laurie A. Whittaker

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 39　No. 3　p. 776-788　2009/03　Research paper (scientific journal)

The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2

Kenji Kurokawa, Hanna Lee, Kyung-Baeg Roh, Miwako Asanuma, Young Sook Kim, Hiroshi Nakayama, Akiko Shiratsuchi, Youngnim Choi, Osamu Takeuchi, Hee Jung Kang, Naoshi Dohmae, Yoshinobu Nakanishi, Shizuo Akira, Kazuhisa Sekimizu, Bok Luel Lee

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 284　No. 13　p. 8406-8411　2009/03　Research paper (scientific journal)

[Role of TLR-dependent and independent pathways in autoimmunity].

Kumagai Y, Akira S

Nihon rinsho. Japanese journal of clinical medicine　Vol. 67　No. 3　p. 487-493　2009/03

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Sho Yamasaki, Makoto Matsumoto, Osamu Takeuchi, Tetsuhiro Matsuzawa, Eri Ishikawa, Machie Sakuma, Hiroaki Tateno, Jun Uno, Jun Hirabayashi, Yuzuru Mikami, Kiyoshi Takeda, Shizuo Akira, Takashi Saito

Proceedings of the National Academy of Sciences of the United States of America　Vol. 106　No. 6　p. 1897-1902　2009/02/10　Research paper (scientific journal)

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

Thierry Roger, Celine Froidevaux, Didier Le Roy, Marlies Knaup Reymond, Anne-Laure Chanson, Davide Mauri, Kim Burns, Beat Michel Riederer, Shizuo Akira, Thierry Calandra

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 106　No. 7　p. 2348-2352　2009/02　Research paper (scientific journal)

Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-beta Signaling Pathway

Ju-Hyun Kim, Seon-Ju Kim, Im-Soon Lee, Myung-Shik Lee, Satoshi Uematsu, Shizuo Akira, Kwon Ik Oh

JOURNAL OF IMMUNOLOGY　Vol. 182　No. 4　p. 2458-2466　2009/02　Research paper (scientific journal)

Involvement of linear polyubiquitylation of NEMO in NF-kappa B activation

Fuminori Tokunaga, Shin-ichi Sakata, Yasushi Saeki, Yoshinori Satomi, Takayoshi Kirisako, Kiyoko Kamei, Tomoko Nakagawa, Michiko Kato, Shigeo Murata, Shoji Yamaoka, Masahiro Yamamoto, Shizuo Akira, Toshifumi Takao, Keiji Tanaka, Kazuhiro Iwai

NATURE CELL BIOLOGY　Vol. 11　No. 2　p. 123-U40　2009/02　Research paper (scientific journal)

A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant

Kouji Kobiyama, Fumihiko Takeshita, Ken J. Ishii, Shohei Koyama, Taiki Aoshi, Shizuo Akira, Asako Sakaue-Sawano, Atsushi Miyawaki, Yuko Yamanaka, Hisashi Hirano, Koichi Suzuki, Kenji Okuda

Journal of Immunology　Vol. 182　No. 3　p. 1593-1601　2009/02/01　Research paper (scientific journal)

Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase

Li Li, Tetsuji Tanaka, Kazunori Yukawa, Shizuo Akira, Naohiko Umesaki

International Journal of Oncology　Vol. 34　No. 4　p. 905-914　2009　Research paper (scientific journal)

Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?

Hua Huang, Shizuo Akira, Manuela M. Santos

Hepatology　Vol. 49　No. 3　p. 1012-1016　2009　Research paper (scientific journal)

The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation

Sanae Haga, Michitaka Ozaki, Hiroshi Inoue, Yasuo Okamoto, Wataru Ogawa, Kiyoshi Takeda, Shizuo Akira, Satoru Todo

Hepatology　Vol. 49　No. 1　p. 204-214　2009　Research paper (scientific journal)

The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice

Yana Filipovich, Shi-Jiang Lu, Shizuo Akira, Emmet Hirsch

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY　Vol. 200　No. 1　2009/01　Research paper (scientific journal)

INHIBITION OF INTERLEUKIN-10 SIGNALING IN LUNG DENDRITIC CELLS BY TOLL-LIKE RECEPTOR 4 LIGANDS

Purnima Jose, Margarita G. Avdiushko, Shizuo Akira, Alan M. Kaplan, Donald A. Cohen

EXPERIMENTAL LUNG RESEARCH　Vol. 35　No. 1　p. 1-28　2009　Research paper (scientific journal)

TLR4 Ligands Induce IFN-alpha Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-beta Priming

Christophe Richez, Kei Yasuda, Amanda A. Watkins, Shizuo Akira, Robert Lafyatis, Jean M. van Seventer, Ian R. Rifkin

JOURNAL OF IMMUNOLOGY　Vol. 182　No. 2　p. 820-828　2009/01　Research paper (scientific journal)

Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene-like receptors, which synergize to induce type I interferon production

Simon B. Rasmussen, Soren B. Jensen, Christoffer Nielsen, Emanuel Quartin, Hiroki Kato, Zhijian J. Chen, Robert H. Silverman, Shizuo Akira, Soren R. Paludan

JOURNAL OF GENERAL VIROLOGY　Vol. 90　p. 74-78　2009/01　Research paper (scientific journal)

Innate immunity to virus infection

Osamu Takeuchi, Shizuo Akira

IMMUNOLOGICAL REVIEWS　Vol. 227　No. 1　p. 75-86　2009/01

Lipid a receptor TLR4-mediated signaling pathways

Shizuo Akira, Masahiro Yamamoto

Advances in Experimental Medicine and Biology　Vol. 667　p. 59-68　2009　Research paper (scientific journal)

Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins

Tetsuo Tsuchida, Taro Kawai, Shizuo Akira

Cell Research　Vol. 19　No. 1　p. 3-4　2009/01　Research paper (scientific journal)

The roles of TLRs, RLRs and NLRs in pathogen recognition

Taro Kawai, Shizuo Akira

International Immunology　Vol. 21　No. 4　p. 317-337　2009

Induction of adaptive immunity by flagellin does not require robust activation of innate immunity

Catherine J. Sanders, Luigi Franchi, Felix Yarovinsky, Satoshi Uematsu, Shizuo Akira, Gabriel Núñez, Andrew T. Gewirtz

European Journal of Immunology　Vol. 39　No. 2　p. 359-371　2009　Research paper (scientific journal)

Immune responses of TLR5+ lamina propria dendritic cells in enterobacterial infection

Satoshi Uematsu, Shizuo Akira

Journal of Gastroenterology　Vol. 44　No. 8　p. 803-811　2009

Immune interventions of human diseases through toll-like receptors

Cevayir Cohan, Ken J. Ishii, Shizuo Akira

Advances in Experimental Medicine and Biology　Vol. 655　p. 63-80　2009　Research paper (scientific journal)

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

Kohichi Matsunaga, Tatsuya Saitoh, Keisuke Tabata, Hiroko Omori, Takashi Satoh, Naoki Kurotori, Ikuko Maejima, Kanae Shirahama-Noda, Tohru Ichimura, Toshiaki Isobe, Shizuo Akira, Takeshi Noda, Tamotsu Yoshimori

Nature Cell Biology　Vol. 11　No. 4　p. 385-396　2009　Research paper (scientific journal)

Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium

Hiroyuki Saiga, Junichi Nishimura, Hirotaka Kuwata, Megumi Okuyama, Sohkichi Matsumoto, Shintaro Sato, Makoto Matsumoto, Shizuo Akira, Yasunobu Yoshikai, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

Journal of Immunology　Vol. 181　No. 12　p. 8521-8527　2008/12/15　Research paper (scientific journal)

CCAAT/enhancer-binding protein β promotes osteoblast differentiation by enhancing Runx2 activity with ATF4

Hiroyuki Tominaga, Shingo Maeda, Makoto Hayashi, Shu Takeda, Shizuo Akira, Setsuro Komiya, Takashi Nakamura, Haruhiko Akiyama, Takeshi Imamura

Molecular Biology of the Cell　Vol. 19　No. 12　p. 5373-5386　2008/12　Research paper (scientific journal)

Viral 5 '-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses

Ramanjaneyulu Allam, Rahul D. Pawar, Onkar P. Kulkarni, Veit Hornung, Gunter Hartman, Stephan Segerer, Shizuo Akira, Stefan Endres, Hans-Joachim Anders

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 38　No. 12　p. 3487-3498　2008/12　Research paper (scientific journal)

Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation

Stephanie D. Lewis, Niranjan B. Butchi, Mohammed Khaleduzzaman, Tim W. Morgan, Min Du, Susan Pourciau, David G. Baker, Shizuo Akira, Karin E. Peterson

JOURNAL OF NEUROVIROLOGY　Vol. 14　No. 6　p. 492-502　2008/12　Research paper (scientific journal)

RIG-I-like antiviral protein in flies

Osamu Takeuchi, Shizuo Akira

NATURE IMMUNOLOGY　Vol. 9　No. 12　p. 1327-1328　2008/12

TLR7-dependent and Fc gamma R-independent production of type I interferon in experimental mouse lupus

Pui Y. Lee, Yutaro Kumagai, Yi Li, Osamu Takeuchi, Hideo Yoshida, Jason Weinstein, Erinn S. Kellner, Dina Nacionales, Tolga Barker, Kindra Kelly-Scumpia, Nico van Rooijen, Himanshu Kumar, Taro Kawai, Minoru Satoh, Shizuo Akira, Westley H. Reeves

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 205　No. 13　p. 2995-3006　2008/12　Research paper (scientific journal)

Toll-Like Receptor 2 Mediates Apolipoprotein CIII-Induced Monocyte Activation

Akio Kawakami, Mizuko Osaka, Masanori Aikawa, Satoshi Uematsu, Shizuo Akira, Peter Libby, Kentaro Shimokado, Frank M. Sacks, Masayuki Yoshida

CIRCULATION RESEARCH　Vol. 103　No. 12　p. 1402-U132　2008/12　Research paper (scientific journal)

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway

Ryoko Yoshida, Giichi Takaesu, Hideyuki Yoshida, Fuyuki Okamoto, Tomoko Yoshioka, Yongwon Choi, Shizuo Akira, Taro Kawai, Akihiko Yoshimura, Takashi Kobayashi

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 52　p. 36211-36220　2008/12　Research paper (scientific journal)

[Autophagy and innate immunity].

Saitoh T, Fujita N, Yoshimori T, Akira S

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　Vol. 53　No. 16 Suppl　p. 2279-2285　2008/12　Research paper (scientific journal)

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu, Keiji Tanaka, Taro Kawai, Tohru Tsujimura, Osamu Takeuchi, Tamotsu Yoshimori, Shizuo Akira

Nature　Vol. 456　No. 7219　p. 264-268　2008/11/13　Research paper (scientific journal)

樹状細胞機能を制御する分子基盤 マウス樹状細胞からのIL-10産生におけるTLR4とTLR2との相乗作用(TLR4 acts in synergy with TLR2 in IL-10 production by murine dendritic cells)

Hirata Noriyuki, Yanagawa Yoshiki, Ebihara Takashi, Seya Tsukasa, Uematsu Satoshi, Akira Shizuo, Hayashi Fumie, Iwabuchi Kazuya, Onoe Kazunori

日本免疫学会総会・学術集会記録　Vol. 38　p. 124-124　2008/11

5 '-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

Hendrik Poeck, Robert Besch, Cornelius Maihoefer, Marcel Renn, Damia Tormo, Svetlana Shulga Morskaya, Susanne Kirschnek, Evelyn Gaffal, Jennifer Landsberg, Johannes Hellmuth, Andreas Schmidt, David Anz, Michael Bscheider, Tobias Schwerd, Carola Berking, Carole Bourquin, Ulrich Kalinke, Elisabeth Kremmer, Hiroki Kato, Shizuo Akira, Rachel Meyers, Georg Haecker, Michael Neuenhahn, Dirk Busch, Juergen Ruland, Simon Rothenfusser, Marco Prinz, Veit Hornung, Stefan Endres, Thomas Tueting, Gunther Hartmann

NATURE MEDICINE　Vol. 14　No. 11　p. 1256-1263　2008/11　Research paper (scientific journal)

Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits XFN-alpha responses by pDC

Zoe Waibler, Martina Anzaghe, Abdo Konur, Shizuo Akira, Werner Mueller, Ulrich Kalinke

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 38　No. 11　p. 3127-3137　2008/11　Research paper (scientific journal)

Signaling flux redistribution at toll-like receptor pathway junctions

Kumar Selvarajoo, Yasunari Takada, Jin Gohda, Mohamed Helmy, Shizuo Akira, Masaru Tomita, Masa Tsuchiya, Jun-Ichiro Inoue, Koichi Matsuo

PLoS ONE　Vol. 3　No. 10　2008/10/17　Research paper (scientific journal)

ワクチンとアジュバント

小山 正平, 石井 健, 審良 静男

インフルエンザ　Vol. 9　No. 4　p. 283-291　2008/10

Targeted disruption of Hsp110/105 gene protects against ischemic stress

Junji Nakamura, Motoaki Fujimoto, Kunihiko Yasuda, Kiyoshi Takeda, Shizuo Akira, Takumi Hatayama, Yasushi Takagi, Kazuhiko Nozaki, Nobuko Hosokawa, Kazuhiro Nagata

Stroke　Vol. 39　No. 10　p. 2853-2859　2008/10/01　Research paper (scientific journal)

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

Patricia A. Taylor, Michael J. Ehrhardt, Christopher J. Lees, Angela Panoskaltsis-Mortari, Arthur M. Krieg, Arlene H. Sharpe, William J. Murphy, Jonathan S. Serody, Hiroaki Hemmi, Shizuo Akira, Robert B. Levy, Bruce R. Blazar

BLOOD　Vol. 112　No. 8　p. 3508-3516　2008/10　Research paper (scientific journal)

Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly

Michael S. Y. Huen, Jun Huang, Jingsong Yuan, Masahiro Yamamoto, Shizuo Akira, Carolyn Ashley, Wei Xiao, Junjie Chen

MOLECULAR AND CELLULAR BIOLOGY　Vol. 28　No. 19　p. 6104-6112　2008/10　Research paper (scientific journal)

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

Qing Zhu, Colt Egelston, Aravindhan Vivekanandhan, Satoshi Uematsu, Shizuo Akira, Dennis M. Klinman, Igor M. Belyakov, Jay A. Berzofsky

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 105　No. 42　p. 16260-16265　2008/10　Research paper (scientific journal)

Potential link between the immune system and metabolism of nucleic acids

Ken J Ishii, Shizuo Akira

Current Opinion in Immunology　Vol. 20　No. 5　p. 524-529　2008/10

IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions

Takumi Koga, Hiroko Endo, Yasuhiro Miyamoto, Mutsuko Mukai, Shizuo Akira, Masahiro Inoue

Cancer Letters　Vol. 268　No. 1　p. 82-88　2008/09/08　Research paper (scientific journal)

Innate immune response to viral infection

Shohei Koyama, Ken J. Ishii, Cevayir Coban, Shizuo Akira

Cytokine　Vol. 43　No. 3　p. 336-341　2008/09

Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei

Kiwamu Nakamura, Akiko Miyazato, Yoshinobu Koguchi, Yoshiyuki Adachi, Naohito Ohno, Shinobu Saijo, Yoichiro Iwakura, Kiyoshi Takeda, Shizuo Akira, Jiro Fujita, Keiko Ishii, Mitsuo Kaku, Kazuyoshi Kawakami

MICROBES AND INFECTION　Vol. 10　No. 10-11　p. 1223-1227　2008/08　Research paper (scientific journal)

Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S-enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88

Gemma L. Foster, Tom A. Barr, Andrew J. Grant, Trevelyan J. McKinley, Clare E. Bryant, Andrew MacDonald, David Gray, Masahiro Yamamoto, Shizuo Akira, Duncan J. Maskell, Pietro Mastroeni

IMMUNOLOGY　Vol. 124　No. 4　p. 469-479　2008/08　Research paper (scientific journal)

Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IκBζ-/- mice

Mayumi Ueta, Junji Hamuro, Eiichiro Ueda, Norito Katoh, Masahiro Yamamoto, Kiyoshi Takeda, Shizuo Akira, Shigeru Kinoshita

Investigative Ophthalmology and Visual Science　Vol. 49　No. 8　p. 3387-3394　2008/08　Research paper (scientific journal)

Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APCMin/+ mice

N. Elander, J. Ungerbäck, H. Olsson, S. Uematsu, S. Akira, P. Söderkvist

Biochemical and Biophysical Research Communications　Vol. 372　No. 1　p. 249-253　2008/07/18　Research paper (scientific journal)

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis

Lijie Gong, Fayi Yao, Kristin Hockman, Henry H. Heng, Gregory J. Morton, Kiyoshi Takeda, Shizuo Akira, Malcolm J. Low, Marcelo Rubinstein, Robert G. MacKenzie

Endocrinology　Vol. 149　No. 7　p. 3346-3354　2008/07　Research paper (scientific journal)

STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury

Julia E. Herrmann, Tetsuya Imura, Bingbing Song, Jingwei Qi, Yan Ao, Thu K. Nguyen, Rose A. Korsak, Kiyoshi Takeda, Shizuo Akira, Michael V. Sofroniew

JOURNAL OF NEUROSCIENCE　Vol. 28　No. 28　p. 7231-7243　2008/07　Research paper (scientific journal)

Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice

Toshihiko Kobayashi, Koichiro Takahashi, Yoshinori Nagai, Takuma Shibata, Masako Otani, Shozo Izui, Shizuo Akira, Yoshiyuki Gotoh, Hiroshi Kiyono, Kensuke Miyake

INTERNATIONAL IMMUNOLOGY　Vol. 20　No. 7　p. 881-891　2008/07　Research paper (scientific journal)

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

Minghui Tang, Xudong Wei, Yinshi Guo, Peter Breslin, Shubin Zhang, Shanshan Zhang, Wei Wei, Zhenbiao Xia, Manuel Diaz, Shizuo Akira, Jiwang Zhang

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 205　No. 7　p. 1611-1619　2008/07　Research paper (scientific journal)

Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9

Nina Gratz, Maria Siller, Barbara Schaljo, Zaid A. Pirzada, Irene Gattermeier, Ivo Vojtek, Carsten J. Kirschning, Hermann Wagner, Emmanuelle Charpentier, Pavel Kovarik, Shizuo Akira

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 29　p. 19879-19887　2008/07　Research paper (scientific journal)

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

Rie Kajino-Sakamoto, Maiko Inagaki, Elisabeth Lippert, Shizuo Akira, Sylvie Robine, Kunihiro Matsumoto, Christian Jobin, Jun Ninomiya-Tsuji

JOURNAL OF IMMUNOLOGY　Vol. 181　No. 2　p. 1143-1152　2008/07　Research paper (scientific journal)

Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus

Marie-Laure Santiago-Raber, Shuichi Kikuchi, Paula Borel, Satoshi Uematsu, Shizuo Akira, Brian L. Kotzin, Shozo Izui

JOURNAL OF IMMUNOLOGY　Vol. 181　No. 2　p. 1556-1562　2008/07　Research paper (scientific journal)

Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

Koichi Obata, Hirokazu Katsura, Kan Miyoshi, Takashi Kondo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Shizuo Akira, Koichi Noguchi

Journal of Neurochemistry　Vol. 105　No. 6　p. 2249-2259　2008/06　Research paper (scientific journal)

Distinct roles for MyD88 and toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction

Ok S. Shin, Ralph R. Isberg, Shizuo Akira, Satoshi Uematsu, Aruna K. Behera, Linden T. Hu

INFECTION AND IMMUNITY　Vol. 76　No. 6　p. 2341-2351　2008/06　Research paper (scientific journal)

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Tatsukata Kawagoe, Shintaro Sato, Kazufumi Matsushita, Hiroki Kato, Kosuke Matsui, Yutaro Kumagai, Tatsuya Saitoh, Taro Kawai, Osamu Takeuchi, Shizuo Akira

Nature Immunology　Vol. 9　No. 6　p. 684-691　2008/06　Research paper (scientific journal)

ウイルスワクチン用のアジュバント

小山 正平, ジェバイア・チョバン, 審良 静男, 堀井 俊宏, 石井 健

Virus Report　Vol. 5　No. 1　p. 74-81　2008/05

Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

Christofer Samuelsson, Juergen Hausmann, Henning Lauterbach, Michaela Schmidt, Shizuo Akira, Hermann Wagner, Paul Chaplin, Mark Suter, Meredith O'Keeffe, Hubertus Hochrein

JOURNAL OF CLINICAL INVESTIGATION　Vol. 118　No. 5　p. 1776-1784　2008/05　Research paper (scientific journal)

Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection

Nicolas Zucchini, Gilles Bessou, Stephanie Traub, Scott H. Robbins, Satoshi Uematsu, Shizuo Akira, Lena Alexopoulou, Marc Dalod

JOURNAL OF IMMUNOLOGY　Vol. 180　No. 9　p. 5799-5803　2008/05　Research paper (scientific journal)

TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity

Binzhi Zhang, Ganesan Ramesh, Satoshi Uematsu, Shizuo Akira, W. Brian Reeves

Journal of the American Society of Nephrology　Vol. 19　No. 5　p. 923-932　2008/05　Research paper (scientific journal)

MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis

Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Shizuo Akira, Mamoru Watanabe

Journal of Immunology　Vol. 180　No. 8　p. 5291-5299　2008/04/15　Research paper (scientific journal)

核酸による自然免疫制御とワクチン開発

小山 正平, 審良 静男, 石井 健

小児感染免疫　Vol. 20　No. 1　p. 33-41　2008/04

Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury

Yumiko Imai, Keiji Kuba, G. Greg Neely, Rubina Yaghubian-Malhami, Thomas Perkmann, Geert van Loo, Maria Ermolaeva, Ruud Veldhuizen, Y. H. Connie Leung, Hongliang Wang, Haolin Liu, Yang Sun, Manolis Pasparakis, Manfred Kopf, Christin Mech, Sina Bavari, J. S. Malik Peiris, Arthur S. Slutsky, Shizuo Akira, Malin Hultqvist, Rikard Holmdahl, John Nicholls, Chengyu Jiang, Christoph J. Binder, Josef M. Penninger

CELL　Vol. 133　No. 2　p. 235-249　2008/04　Research paper (scientific journal)

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

Jonathan C. Kagan, Tian Su, Tiffany Horng, Amy Chow, Shizuo Akira, Ruslan Medzhitov

NATURE IMMUNOLOGY　Vol. 9　No. 4　p. 361-368　2008/04　Research paper (scientific journal)

Requirement of toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis

Emina Savarese, Christian Steinberg, Rahul D. Pawar, Wolfgang Reindl, Shizuo Akira, Hans-Joachim Anders, Anne Krug

ARTHRITIS AND RHEUMATISM　Vol. 58　No. 4　p. 1107-1115　2008/04　Research paper (scientific journal)

Pathogen recognition by innate receptors

Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira

Journal of Infection and Chemotherapy　Vol. 14　No. 2　p. 86-92　2008/04

TLR9 as a key receptor for the recognition of DNA

Yutaro Kumagai, Osamu Takeuchi, Shizuo Akira

Advanced Drug Delivery Reviews　Vol. 60　No. 7　p. 795-804　2008/04

Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBP 2-deficient hematopoietic cells

Tadayuki Akagi, Takayuki Saitoh, James O'Kelly, Shizuo Akira, Adrian F. Gombart, H. Phillip Koeffler

Blood　Vol. 111　No. 6　p. 2999-3004　2008/03/15　Research paper (scientific journal)

Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.

Kiwamu Nakamura, Akiko Miyazato, Gang Xiao, Masumitsu Hatta, Ken Inden, Tetsuji Aoyagi, Kohei Shiratori, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Kazuo Suzuki, Jiro Fujita, Mitsuo Kaku, Kazuyoshi Kawakami

Journal of immunology (Baltimore, Md. : 1950)　Vol. 180　No. 6　p. 4067-74　2008/03/15

Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor

Junichi Nishimura, Hiroyuki Saiga, Shintaro Sato, Megumi Okuyama, Hisako Kayama, Hirotaka Kuwata, Sohkichi Matsumoto, Toshirou Nishida, Yoshiki Sawa, Shizuo Akira, Yasunobu Yoshikai, Masahiro Yamamoto, Kiyoshi Takeda

Journal of Immunology　Vol. 180　No. 6　p. 4032-4039　2008/03/15　Research paper (scientific journal)

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

Chul-Su Yang, Dong-Min Shin, Hye-Mi Lee, Ji Woong Son, Sung Joong Lee, Shizuo Akira, Marie-Anne Gougerot-Pocidalo, Jamel El-Benna, Hidenori Ichijo, Eun-Kyeong Jo

CELLULAR MICROBIOLOGY　Vol. 10　No. 3　p. 741-754　2008/03　Research paper (scientific journal)

Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells

Jennifer P. A. Newman, Birendranath Banerjee, Wanru Fang, Anuradha Poonepalli, Lakshmidevi Balakrishnan, Grace Kah Mun Low, Rabindra N. Bhattacharjee, Shizuo Akira, Manikandan Jayapal, Alirio J. Melendez, Rajamanickam Baskar, Han-Woong Lee, M. Prakash Hande

JOURNAL OF CELLULAR PHYSIOLOGY　Vol. 214　No. 3　p. 796-809　2008/03　Research paper (scientific journal)

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9

Christoph Hoelscher, Norbert Reiling, Ulrich E. Schaible, Alexandra Hoelscher, Clara Bathmann, Daniel Korbel, Insa Lenz, Tanja Sonntag, Svenja Kroeger, Shizuo Akira, Horst Mossmann, Carsten J. Kirschning, Hermann Wagner, Marina Freudenberg, Stefan Ehlers

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 38　No. 3　p. 680-694　2008/03　Research paper (scientific journal)

Targeting dendritic cell signaling to regulate the response to immunization

David Escors, Luciene Lopes, Rongtuan Lin, John Hiscott, Shizuo Akira, Roger J. Davis, Mary K. Collins

BLOOD　Vol. 111　No. 6　p. 3050-3061　2008/03　Research paper (scientific journal)

Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease

Matarn Vijay-Kumar, Jesse D. Aitken, Amrita Kumar, Andrew S. Neish, Satoshi Uematsu, Shizuo Akira, Andrew T. Gewirtz

INFECTION AND IMMUNITY　Vol. 76　No. 3　p. 1276-1281　2008/03　Research paper (scientific journal)

Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells

Hajime Hisaeda, Kohhei Tetsutani, Takashi Imai, Chikako Moriya, Liping Tu, Shinjiro Hamano, Xuefeng Duan, Bin Chou, Hidekazu Ishida, Akiko Aramaki, Jianying Shen, Ken J. Ishii, Cevayir Coban, Shizuo Akira, Kiyoshi Takeda, Koji Yasutomo, Motomi Torii, Kunisuke Himeno

Journal of Immunology　Vol. 180　No. 4　p. 2496-2503　2008/02/15　Research paper (scientific journal)

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Ken J. Ishii, Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban, Shizuo Akira

Nature　Vol. 451　No. 7179　p. 725-729　2008/02/07　Research paper (scientific journal)

Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (Nature Immunology (2008) vol. 9 (97-104)

Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean Marc Reichhart

Nature Immunology　Vol. 9　No. 2　2008/02　Research paper (scientific journal)

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Nicholas S. Wilson, Louise J. Young, Fiona Kupresanin, Shalin H. Naik, David Vremec, William R. Heath, Shizuo Akira, Ken Shortman, Jeff Boyle, Eugene Maraskovsky, Gabrielle T. Belz, Jose A. Villadangos

IMMUNOLOGY AND CELL BIOLOGY　Vol. 86　No. 2　p. 200-205　2008/02　Research paper (scientific journal)

Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity

Sun-Young Chang, Hye-Ran Cha, Satoshi Uematsu, Shizuo Akira, Osamu Igarashi, Hiroshi Kiyono, Mi-Na Kweon

JOURNAL OF IMMUNOLOGY　Vol. 180　No. 3　p. 1609-1618　2008/02　Research paper (scientific journal)

MDA5/RIG-I and virus recognition

Osamu Takeuchi, Shizuo Akira

CURRENT OPINION IN IMMUNOLOGY　Vol. 20　No. 1　p. 17-22　2008/02

Activation of cytosolic phospholipase A(2)alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2

Shahid Noor, Howard Goldfine, Dawn E. Tucker, Saritha Suram, Laurel L. Lenz, Shizuo Akira, Satoshi Uematsu, Milena Girotti, Joseph V. Bonventre, Kevin Breuel, David L. Williams, Christina C. Leslie

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 8　p. 4744-4755　2008/02　Research paper (scientific journal)

Induction of prostaglandin E-2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors

Yoshiteru Nakano, Etsushi Kuroda, Tomohiro Kito, Satoshi Uematsu, SHizuo Akira, Akira Yokota, Shigeru Nishizawa, Uki Yamashita

JOURNAL OF NEUROSURGERY　Vol. 108　No. 2　p. 311-319　2008/02　Research paper (scientific journal)

Innate immunity and tubercfulosis

Satoshi Uematsu, Shizuo Akira

Kekkaku　Vol. 83　No. 2　p. 101-109　2008/02　Research paper (international conference proceedings)

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

Jeremy B. Swann, Matthew D. Vesely, Anabel Silva, Janelle Sharkey, Shizuo Akira, Robert D. Schreiber, Mark J. Smyth

Proceedings of the National Academy of Sciences of the United States of America　Vol. 105　No. 2　p. 652-656　2008/01/15　Research paper (scientific journal)

Cutting edge: Cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses

Himanshu Kumar, Shohei Koyama, Ken J. Ishii, Taro Kawai, Shizuo Akira

Journal of Immunology　Vol. 180　No. 2　p. 683-687　2008/01/15　Research paper (scientific journal)

Recognition of pathogens: Toll-like receptors

Satoshi Uematsu, Shizuo Akira

How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling　p. 1-36　2008　Part of collection (book)

The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

Sachie Hiratsuka, Akira Watanabe, Yoshiko Sakurai, Sachiko Akashi-Takamura, Sachie Ishibashi, Kensuke Miyake, Masabumi Shibuya, Shizuo Akira, Hiroyuki Aburatani, Yoshiro Maru

Nature Cell Biology　Vol. 10　No. 11　p. 1349-1355　2008　Research paper (scientific journal)

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

Katalin Karikó, Hiromi Muramatsu, Frank A. Welsh, János Ludwig, Hiroki Kato, Shizuo Akira, Drew Weissman

Molecular Therapy　Vol. 16　No. 11　p. 1833-1840　2008　Research paper (scientific journal)

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

Shahla Abdollahi-Roodsaz, Leo A. B. Joosten, Marije I. Koenders, Isabel Devesa, Mieke F. Roelofs, Timothy R. D. J. Radstake, Marleen Heuvelmans-Jacobs, Shizuo Akira, Martin J. H. Nicklin, Fatima Ribeiro-Dias, Wim B. Van den Berg

JOURNAL OF CLINICAL INVESTIGATION　Vol. 118　No. 1　p. 205-216　2008/01　Research paper (scientific journal)

Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess

Werner Stenzel, Sabine Soltek, Monica Sanchez-Ruiz, Shizuo Akira, Hrvoje Miletic, Dirk Schlueter, Martina Deckert

AMERICAN JOURNAL OF PATHOLOGY　Vol. 172　No. 1　p. 132-145　2008/01　Research paper (scientific journal)

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity

Yueh-Ming Loo, Jamie Fornek, Nanette Crochet, Gagan Bajwa, Olivia Perwitasari, Luis Martinez-Sobrido, Shizuo Akira, Michelle A. Gill, Adolfo Garcia-Sastre, Michael G. Katze, Michael Gale

JOURNAL OF VIROLOGY　Vol. 82　No. 1　p. 335-345　2008/01　Research paper (scientific journal)

Akirins are highly conserved nuclear proteins required for NF-kappa B-dependent gene expression in drosophila and mice

Akira Goto, Kazufumi Matsushita, Viola Gesellchen, Laure El Chamy, David Kuttenkeuler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira, Michael Boutros, Jean-Marc Reichhart

NATURE IMMUNOLOGY　Vol. 9　No. 1　p. 97-104　2008/01　Research paper (scientific journal)

Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders

Kiyofumi Yamakawa, Satoru Kamekura, Naohiro Kawamura, Masatomo Saegusa, Daisuke Kamei, Makoto Murakami, Ichiro Kudo, Satoshi Uematsu, Shizuo Akira, Ung-Il Chung, Kozo Nakamura, Hiroshi Kawaguchi

ARTHRITIS AND RHEUMATISM　Vol. 58　No. 1　p. 172-183　2008/01　Research paper (scientific journal)

Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling

Rabindra N. Bhattacharjee, Kwon-Sam Park, Xiuhao Chen, Tetsuya Lida, Takeshi Hondal, Osamu Takeuchi, Shizuo Akira

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY　Vol. 18　No. 1　p. 171-175　2008/01　Research paper (scientific journal)

Toll-like receptor and RIG-1-like receptor signaling

Taro Kawai, Shizuo Akira

Annals of the New York Academy of Sciences　Vol. 1143　p. 1-20　2008

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88

Andreas Jung, Hiroki Kato, Yutaro Kumagai, Himanshu Kumar, Taro Kawai, Osamu Takeuchi, Shizuo Akira

Journal of Virology　Vol. 82　No. 1　p. 196-206　2008/01　Research paper (scientific journal)

Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif

Issa Abu-Dayyeh, Marina Tiemi Shio, Shintaro Sato, Shizuo Akira, Benoit Cousineau, Martin Olivier

PLoS Neglected Tropical Diseases　Vol. 2　No. 12　2008　Research paper (scientific journal)

Toll-like receptors (TLRs) and their ligands

Satoshi Uematsu, Shizuo Akira

Handbook of Experimental Pharmacology　Vol. 183　No. 183　p. 1-20　2008　Research paper (scientific journal)

Loss of Atg16L1, an autophagy regulator, enhances endotoxin-induced IL-1 production

Saitoh, T, Fujita, N, Ho Jang, M. H, Uematsu, S, Yang, B-C, Satoh, T, Omori, H, Noda, T, Yamamoto, N, Komatsu, M, Tanaka, K, Kawai, T, Tsujimura, T, Takeuchi, O, Yoshimori, T, Akira, S

Nature　Vol. 456　p. 264-268　2008

Immunoadjuvant effects of polyadenylic: Polyuridylic acids through TLR3 and TLR7

Takahiro Sugiyama, Katsuaki Hoshino, Masuyoshi Saito, Takahiro Yano, Izumi Sasaki, Chihiro Yamazaki, Shizuo Akira, Tsuneyasu Kaisho

International Immunology　Vol. 20　No. 1　p. 1-9　2008/01　Research paper (scientific journal)

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

Pamela Gasse, Caroline Mary, Isabelle Guenon, Nicolas Noulin, Sabine Charron, Silvia Schnyder-Candrian, Bruno Schnyder, Shizuo Akira, Valerie F. J. Quesniaux, Vincent Lagente, Bernhard Ryffel, Isabelle Couillin

JOURNAL OF CLINICAL INVESTIGATION　Vol. 117　No. 12　p. 3786-3799　2007/12　Research paper (scientific journal)

IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc epsilon RI signals

Lien H. Ho, Tatsukuni Ohno, Keisuke Oboki, Naoki Kajiwara, Hajime Suto, Motoyasu Iikura, Yoshimichi Okayama, Shizuo Akira, Hirohisa Saito, Stephen J. Galli, Susumu Nakae

JOURNAL OF LEUKOCYTE BIOLOGY　Vol. 82　No. 6　p. 1481-1490　2007/12　Research paper (scientific journal)

Deletion of TLR5 results in spontaneous colitis in mice

Matam Vijay-Kumar, Catherine J. Sanders, Rebekah T. Taylor, Amrita Kumar, Jesse D. Aitken, Shanthi V. Sitaraman, Andrew S. Neish, Satoshi Uematsu, Shizuo Akira, Ifor R. Williams, Andrew T. Gewirtz

JOURNAL OF CLINICAL INVESTIGATION　Vol. 117　No. 12　p. 3909-3921　2007/12　Research paper (scientific journal)

Recognition of viruses by innate immunity

Osamu Takeuchi, Shizuo Akira

IMMUNOLOGICAL REVIEWS　Vol. 220　No. 1　p. 214-224　2007/12

The HTLV-I Tax oncoprotein requires the ubiquitin conjugating enzyme Ubc13 for NF-κB activation.

Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW

J Virol.　Vol. 81　No. 24　p. 13735-13742　2007/12

Modified vaccinia virus Ankara induces toll-like receptor-independent type I interferon responses

Zoe Waibler, Martina Anzaghe, Holger Ludwig, Shizuo Akira, Siegfried Weiss, Gerd Sutter, Ulrich Kalinke

JOURNAL OF VIROLOGY　Vol. 81　No. 22　p. 12102-12110　2007/11　Research paper (scientific journal)

Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila

Thomas R. Hawn, William R. Berrington, Ian A. Smith, Satoshi Uematsu, Shizuo Akira, Alan Aderem, Kelly D. Smith, Shawn J. Skerrett

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 10　p. 6981-6987　2007/11　Research paper (scientific journal)

FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction

Rachel Zhande, Shauna M. Dauphinee, James A. Thomas, Masahiro Yamamoto, Shizuo Akira, Aly Karsan

Molecular and Cellular Biology　Vol. 27　No. 21　p. 7394-7404　2007/11　Research paper (scientific journal)

Signal Transducer and Activator of Transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice

Ryotaro Sakamori, Tetsuo Takehara, Chihiro Ohnishi, Tomohide Tatsumi, Kazuyoshi Ohkawa, Kiyoshi Takeda, Shizuo Akira, Norio Hayashi

Hepatology　Vol. 46　No. 5　p. 1564-1573　2007/11　Research paper (scientific journal)

Signaling to NF-κB by Toll-like receptors

Taro Kawai, Shizuo Akira

Trends in Molecular Medicine　Vol. 13　No. 11　p. 460-469　2007/11

The C/EBPβ isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing

Satoshi Uematsu, Tsuneyasu Kaisho, Takashi Tanaka, Makoto Matsumoto, Megumi Yamakami, Hiroko Omori, Masahiro Yamamoto, Tamotsu Yoshimori, Shizuo Akira

Journal of Immunology　Vol. 179　No. 8　p. 5378-5386　2007/10/15　Research paper (scientific journal)

Calcineurin negatively regulates TLR-Mediated activation pathways

Young Jun Kang, Brenda Kusler, Motoyuki Otsuka, Michael Hughes, Nobutaka Suzuki, Shinobu Suzuki, Wen-Chen Yeh, Shizuo Akira, Jiahuai Han, Patricia P. Jones

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 7　p. 4598-4607　2007/10　Research paper (scientific journal)

Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif

Pamela Cook, Sabine Toetemeyer, Catherine Stevenson, Katherine A. Fitzgerald, Masahiro Yamamoto, Shizuo Akira, Duncan J. Maskell, Clare E. Bryant

IMMUNOLOGY　Vol. 122　No. 2　p. 222-229　2007/10　Research paper (scientific journal)

Genetic analysis of resistance to viral infection

Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean-Luc Imler, Osamu Takeuchi, Jules A. Hoffmann, Shizuo Akira

NATURE REVIEWS IMMUNOLOGY　Vol. 7　No. 10　p. 753-766　2007/10

Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination

Shohei Koyama, Ken J. Ishii, Himanshu Kumar, Takeshi Tanimoto, Cevayir Coban, Satoshi Uematsu, Taro Kawai, Shizuo Akira

Journal of Immunology　Vol. 179　No. 7　p. 4711-4720　2007/10/01　Research paper (scientific journal)

Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance

Subhra K. Biswas, Pradeep Bist, Manprit Kaur Dhillon, Tasneem Kajiji, Carlos Del Fresno, Masahiro Yamamoto, Eduardo Lopez-Collazo, Shizuo Akira, Vinay Tergaonkar

Journal of Immunology　Vol. 179　No. 6　p. 4083-4092　2007/09/15　Research paper (scientific journal)

Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency

Masahiro Yamamoto, Satoshi Uematsu, Toru Okamoto, Yoshiharu Matsuura, Shintaro Sato, Himanshu Kumar, Takashi Satoh, Tatsuya Saitoh, Kiyoshi Takeda, Ken J. Ishii, Osamu Takeuchi, Taro Kawai, Shizuo Akira

Journal of Experimental Medicine　Vol. 204　No. 9　p. 2233-2239　2007/09/03　Research paper (scientific journal)

MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus

Karl Lang, Alexander A. Navarini, Mike Recher, Philipp A. Lang, Mathias Heikenwalder, Barbara Stecher, Andreas Bergthaler, Bernhard Odermatt, Shizuo Akira, Kenya Honda, Hans Hengartner, Rolf M. Zinkernagel

European Journal of Immunology　Vol. 37　No. 9　p. 2434-2440　2007/09　Research paper (scientific journal)

TLR9 is required for protective innate immunity in gram-negative bacterial pneumonia: Role of dendritic cells

Urvashi Bhan, Nicholas W. Lukacs, John J. Osterholzer, Michael W. Newstead, Xianying Zeng, Thomas A. Moore, Tracy R. McMillan, Arthur M. Krieg, Shizuo Akira, Theodore J. Standiford

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 6　p. 3937-3946　2007/09　Research paper (scientific journal)

Nitrogen dioxide promotes allergic Sensitization to inhaled antigen

Mieke Bevelander, Jana Mayette, Laurie A. Whittaker, Sara A. Paveglio, Christine C. Jones, Justin Robbins, David Hemenway, Shizuo Akira, Satoshi Uematsu, Matthew E. Poynter

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 6　p. 3680-3688　2007/09　Research paper (scientific journal)

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

Takayuki Abe, Yuuki Kaname, Itsuki Hamamoto, Yoshimi Tsuda, Xiaoyu Wen, Shuhei Taguwa, Kohji Moriishi, Osamu Takeuchi, Taro Kawai, Tatsuya Kanto, Norio Hayashi, Shizuo Akira, Yoshiharu Matsuura

Journal of Virology　Vol. 81　No. 17　p. 8953-8966　2007/09　Research paper (scientific journal)

The Atg5-Atg12 conjugate associates with innate antiviral immune responses

Nao Jounai, Fumihiko Takeshita, Kouji Kobiyama, Asako Sawano, Atsushi Miyawaki, Ke-Qin Xin, Ken J. Ishii, Taro Kawai, Shizuo Akira, Koichi Suzuki, Kenji Okuda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 104　No. 35　p. 14050-14055　2007/08/28　Research paper (scientific journal)

Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses

Yutaro Kumagai, Osamu Takeuchi, Hiroki Kato, Himanshu Kumar, Kosuke Matsui, Eiichi Morii, Katsuyuki Aozasa, Taro Kawai, Shizuo Akira

Immunity　Vol. 27　No. 2　p. 240-252　2007/08/24　Research paper (scientific journal)

Toll-like receptor and innate immunity

Satoshi Uematsu, Shizuo Akira

SEIKAGAKU　Vol. 79　No. 8　p. 769-776　2007/08

Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells

Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki

NATURE　Vol. 448　No. 7156　p. 929-U7　2007/08　Research paper (scientific journal)

Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes

Hun Sik Kim, Myoung Sook Han, Kun Wook Chung, Sunshin Kim, Eunshil Kim, Myoung Joo Kim, Eunkyeong Jang, Hyun Ah Lee, Jeehee Youn, Shizuo Akira, Myung-Shik Lee

IMMUNITY　Vol. 27　No. 2　p. 321-333　2007/08　Research paper (scientific journal)

Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself

Jiali Li, Wenru Song, Debra K. Czerwinski, Bindu Varghese, Satoshi Uematsu, Shizuo Akira, Arthur M. Krieg, Ronald Levy

JOURNAL OF IMMUNOLOGY　Vol. 179　No. 4　p. 2493-2500　2007/08　Research paper (scientific journal)

Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine

Sukumar Saha, Fumihiko Takeshita, Tomoko Matsuda, Nao Jounai, Kouji Kobiyama, Tetsuya Matsumoto, Shin Sasaki, Atsushi Yoshida, Ke-Qin Xin, Dennis M. Klinman, Satoshi Uematsu, Ken J. Ishii, Shizuo Akira, Kenji Okuda

Journal of Immunology　Vol. 179　No. 2　p. 1147-1154　2007/07/15　Research paper (scientific journal)

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice

Ganesan Ramesh, Binzhi Zhang, Satoshi Uematsu, Shizuo Akira, W. Brian Reeves

American Journal of Physiology - Renal Physiology　Vol. 293　No. 1　p. F325-F332　2007/07　Research paper (scientific journal)

Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population

Kayoko Tao, Mutsuko Fujii, Shin-Ichi Tsukumo, Yoichi Maekawa, Kenji Kishihara, Yasutaka Kimoto, Takahiko Horiuchi, Hajime Hisaeda, Shizuo Akira, Shoji Kagami, Koji Yasutomo

Annals of the Rheumatic Diseases　Vol. 66　No. 7　p. 905-909　2007/07　Research paper (scientific journal)

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chun-Jen Chen, Hajime Kono, Douglas Golenbock, George Reed, Shizuo Akira, Kenneth L. Rock

NATURE MEDICINE　Vol. 13　No. 7　p. 851-856　2007/07　Research paper (scientific journal)

Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

Fumiyo Ikeda, Christina Maria Hecker, Alexis Rozenknop, Rolf Dietrich Nordmeier, Vladimir Rogov, Kay Hofmann, Shizuo Akira, Volker Doetsch, Ivan Dikic

EMBO JOURNAL　Vol. 26　No. 14　p. 3451-3462　2007/07　Research paper (scientific journal)

Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and toll-like receptors

Jin-Hwan Han, Shizuo Akira, Kathryn Calame, Bruce Beutler, Erik Selsing, Thereza Imanishi-Kari

IMMUNITY　Vol. 27　No. 1　p. 64-75　2007/07　Research paper (scientific journal)

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis

Zachary J. Roberts, Nadege Goutagny, Pin-Yu Perera, Hiroki Kato, Himanshu Kumar, Taro Kawai, Shizuo Akira, Ram Savan, David van Echo, Katherine A. Fitzgerald, Howard A. Young, Lai-Ming Ching, Stefanie N. Vogel

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 204　No. 7　p. 1559-1569　2007/07　Research paper (scientific journal)

A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells

Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, Yuichi Torii, Seiji Shinkai, Shizuo Akira, Ken J. Ishii, Kazuo Sakurai

Bioconjugate Chemistry　Vol. 18　No. 4　p. 1280-1286　2007/07　Research paper (scientific journal)

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.

Ramesh G, Zhang B, Uematsu S, Akira S, Reeves WB

American journal of physiology. Renal physiology　Vol. 293　No. 1　p. F325-32　2007/07

Murine dendritic cell type IIFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production

Kei Yasuda, Christophe Richez, Joseph W. Maciaszek, Neerja Agrawal, Shizuo Akira, Ann Marshak-Rothstein, Ian R. Rifkin

JOURNAL OF IMMUNOLOGY　Vol. 178　No. 11　p. 6876-6885　2007/06　Research paper (scientific journal)

Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a

Doo-Hee Shim, Sun-Young Chang, Sung-Moo Park, Hyun Jang, Rodney Carbis, Cecil Czerkinsky, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon

VACCINE　Vol. 25　No. 25　p. 4828-4836　2007/06　Research paper (scientific journal)

ER stress triggers apoptosis by activating BH3-only protein Bim

Hamsa Puthalakath, Lorraine A. O'Reilly, Priscilla Gunn, Lily Lee, Priscilla N. Kelly, Nicholas D. Huntington, Peter D. Hughes, Ewa M. Michalak, Jennifer McKimm-Breschkin, Noburo Motoyama, Tomomi Gotoh, Shizuo Akira, Philippe Bouillet, Andreas Strasser

CELL　Vol. 129　No. 7　p. 1337-1349　2007/06　Research paper (scientific journal)

SnapShot: Pattern-recognition receptors.

Kawai T, Akira S

Cell　Vol. 129　No. 5　2007/06

Manipulation of host innate immune responses by the malaria parasite

Cevayir Coban, Ken J. Ishii, Toshihiro Horii, Shizuo Akira

Trends in Microbiology　Vol. 15　No. 6　p. 271-278　2007/06

Cutting edge: TLR2 directly triggers Th1 effector functions

Takayuki Imanishi, Hiromitsu Hara, Shinobu Suzuki, Nobutaka Suzuki, Shizuo Akira, Takashi Saito

Journal of Immunology　Vol. 178　No. 11　p. 6715-6719　2007/06/01　Research paper (scientific journal)

Toll-like receptors and type I Interferons

Satoshi Uematsu, Shizuo Akira

Journal of Biological Chemistry　Vol. 282　No. 21　p. 15319-15324　2007/05/25

Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia

Mark C. Dessing, Koenraad F. van der Sluijs, Sandrine Florquin, Shizuo Akira, Tom van der Poll

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY　Vol. 36　No. 5　p. 609-614　2007/05　Research paper (scientific journal)

A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity

Donghoon Kim, Myung Ah Kim, Ik-Hyun Cho, Mi Sun Kim, Soojin Lee, Eun-Kyeong Jo, Se-Young Choi, Kyungpyo Park, Joong Soo Kim, Shizuo Akira, Heung Sik Na, Seog Bae Oh, Sung Joong Lee

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 20　p. 14975-14983　2007/05　Research paper (scientific journal)

Deficiencies of myeloid differentiation factor 88, toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori

Marygorret Obonyo, Mojgan Sabet, Sheri P. Cole, Joerg Ebmeyer, Satoshi Uematsu, Shizuo Akira, Donald G. Guiney

INFECTION AND IMMUNITY　Vol. 75　No. 5　p. 2408-2414　2007/05　Research paper (scientific journal)

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira

Journal of Experimental Medicine　Vol. 204　No. 5　p. 1013-1024　2007/05　Research paper (scientific journal)

Interleukin-18 regulates pathological intraocular neovascularization

Hong Qiao, Koh-Hei Sonoda, Yasuhiro Ikeda, Takeru Yoshimura, Kuniaki Hijioka, Young-Joon Jo, Yukio Sassa, Chikako Tsutsumi-Miyahara, Yasuaki Hata, Shizuo Akira, Tatsuro Ishibashi

Journal of Leukocyte Biology　Vol. 81　No. 4　p. 1012-1021　2007/04　Research paper (scientific journal)

Cutting edge: Tlr5(-/-) mice are more susceptible to Escherichia coli urinary tract infection

Erica Andersen-Nissen, Thomas R. Hawn, Kelly D. Smith, Alex Nachman, Aaron E. Lampano, Satoshi Uematsu, Shizuo Akira, Alan Aderem

JOURNAL OF IMMUNOLOGY　Vol. 178　No. 8　p. 4717-4720　2007/04　Research paper (scientific journal)

Signaling pathways activated by microorganisms

Osamu Takeuchi, Shizuo Akira

CURRENT OPINION IN CELL BIOLOGY　Vol. 19　No. 2　p. 185-191　2007/04　Research paper (scientific journal)

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Michaela U. Gack, Young C. Shin, Chul-Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue, Jae U. Jung

NATURE　Vol. 446　No. 7138　p. 916-U2　2007/04　Research paper (scientific journal)

Viral infections activate types I and III interferon genes through a common mechanism

Kazuhide Onoguchi, Mitsutoshi Yoneyama, Azumi Takemura, Shizuo Akira, Tadatsugu Taniguchi, Hideo Namiki, Takashi Fujita

Journal of Biological Chemistry　Vol. 282　No. 10　p. 7576-7581　2007/03/02　Research paper (scientific journal)

Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFκB activation pathways bifurcate at IL-1 receptor-associated kinase modification

Jianhong Yao, Whan Kim Tae, Jinzhong Qin, Zhengfan Jiang, Youcun Qian, Hui Xiao, Yi Lu, Wen Qian, Muhammet Fatih Gulen, Nywana Sizemore, Joseph DiDonato, Shintaro Sato, Shizuo Akira, Bing Su, Xiaoxia Li

Journal of Biological Chemistry　Vol. 282　No. 9　p. 6075-6089　2007/03/02　Research paper (scientific journal)

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection

Barbara Albiger, Sofia Dahlberg, Andreas Sandgren, Florian Wartha, Katharina Beiter, Hiroaki Katsuragi, Shizuo Akira, Staffan Normark, Birgitta Henriques-Normark

Cellular Microbiology　Vol. 9　No. 3　p. 633-644　2007/03　Research paper (scientific journal)

Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo

Svetlana Hamm, Antje Heit, Martina Koffler, Katharina M. Huster, Shizuo Akira, Dirk H. Busch, Herrmann Wagner, Stefan Bauer

INTERNATIONAL IMMUNOLOGY　Vol. 19　No. 3　p. 297-304　2007/03　Research paper (scientific journal)

MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses

Kishore R. Alugupalli, Shizuo Akira, Egil Lien, John M. Leong

JOURNAL OF IMMUNOLOGY　Vol. 178　No. 6　p. 3740-3749　2007/03　Research paper (scientific journal)

Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways

Junko Sawaki, Hiroko Tsutsui, Nobuki Hayashi, Koubun Yasuda, Shizuo Akira, Takakuni Tanizawa, Kenji Nakanishi

INTERNATIONAL IMMUNOLOGY　Vol. 19　No. 3　p. 311-320　2007/03　Research paper (scientific journal)

A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-β in the host response to Pseudomonas aeruginosa lung infection in mice

Melanie R. Power, Bo Li, Masahiro Yamamoto, Shizuo Akira, Tong-Jun Lin

Journal of Immunology　Vol. 178　No. 5　p. 3170-3176　2007/03/01　Research paper (scientific journal)

Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia

Samithamby Jeyaseelan, Scott K. Young, Michael B. Fessler, Yuhong Liu, Kenneth C. Malcolm, Masahiro Yamamoto, Shizuo Akira, G. Scott Worthen

Journal of Immunology　Vol. 178　No. 5　p. 3153-3160　2007/03/01　Research paper (scientific journal)

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

Luisa Cervantes-Barragan, Roland Zuest, Friedernann Weber, Martin Spiegel, Karl S. Lang, Shizuo Akira, Volker Thiel, Burkhard Ludewig

BLOOD　Vol. 109　No. 3　p. 1131-1137　2007/02　Research paper (scientific journal)

TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses

Alex K. Heer, Abdijapar Shamshiev, Alena Donda, Satoshi Uematsu, Shizuo Akira, Manfred Kopf, Benjamin J. Marsland

JOURNAL OF IMMUNOLOGY　Vol. 178　No. 4　p. 2182-2191　2007/02　Research paper (scientific journal)

NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1

Sinead M. Miggin, Eva Palsson-McDermott, Aisling Dunne, Caroline Jefferies, Emmanuel Pinteaux, Kathy Banahan, Caroline Murphy, Paul Moynagh, Masahiro Yamamoto, Shizuo Akira, Nancy Rothwelll, Douglas Golenbock, Katherine A. Fitzgerald, Luke A. J. O'Neill

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 9　p. 3372-3377　2007/02　Research paper (scientific journal)

TLR signaling

Taro Kawai, Shizuo Akira

Seminars in Immunology　Vol. 19　No. 1　p. 24-32　2007/02

Antiviral signaling through pattern recognition receptors

Taro Kawai, Shizuo Akira

Journal of Biochemistry　Vol. 141　No. 2　p. 137-145　2007/02

Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans

Shinobu Saijo, Noriyuki Fujikado, Takahisa Furuta, Soo-Hyun Chung, Hayato Kotaki, Keisuke Seki, Katsuko Sudo, Shizuo Akira, Yoshiyuki Adachi, Naohito Ohno, Takeshi Kinjo, Kiwamu Nakamura, Kazuyoshi Kawakami, Yoichiro Iwakura

Nature Immunology　Vol. 8　No. 1　p. 39-46　2007/01　Research paper (scientific journal)

The Biology of Toll-Like Receptors in Mice

Osamu Takeuchi, Shizuo Akira

The Mouse in Biomedical Research　Vol. 4　p. 109-117　2007　Part of collection (book)

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

Takeshi Saito, Reiko Hirai, Yueh-Ming Loo, David Owen, Cynthia L. Johnson, Sangita C. Sinha, Shizuo Akira, Takashi Fujita, Michael Gale

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 104　No. 2　p. 582-587　2007/01　Research paper (scientific journal)

Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury

Yasushi Sakata, Jian-Wen Dong, Jesus G. Vallejo, Chien-Hua Huang, J. Scott Baker, Kevin J. Tracey, Osamu Tacheuchi, Shizuo Akira, Douglas L. Mann

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 292　No. 1　p. H503-H509　2007/01　Research paper (scientific journal)

DNA and RNA autoantigens as autoadjuvants

Liliana Busconi, Christina M. Lau, Abigail S. Tabor, Melissa B. Uccellini, Zachary Ruhe, Shizuo Akira, Gregory A. Viglianti, Ian R. Rifkin, Ann Marshak-Rothstein

Journal of Endotoxin Research　Vol. 12　No. 6　p. 379-384　2006/12　Research paper (scientific journal)

IL-21-induced B epsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses

Michishige Harada, Kumiko Magara-Koyanagi, Hiroshi Watarai, Yuko Nagata, Yasuyuki Ishii, Satoshi Kojo, Shigetoshi Horiguchi, Yoshitaka Okamoto, Toshinori Nakayama, Nobutaka Suzuki, Wen-Chen Yeh, Shizuo Akira, Hiroshi Kitamura, Osamu Ohara, Ken-ichiro Seino, Masaru Taniguchi

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 203　No. 13　p. 2929-2937　2006/12　Research paper (scientific journal)

Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals

Andre Boonstra, Ricardo Rajsbaum, Mary Holman, Rute Marques, Carine Asselin-Paturel, Joao Pedro Pereira, Elizabeth E. M. Bates, Shizuo Akira, Paulo Vieira, Yong-Jun Liu, Giorgio Trinchieri, Anne O'Garra

JOURNAL OF IMMUNOLOGY　Vol. 177　No. 11　p. 7551-7558　2006/12　Research paper (scientific journal)

Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis

Takahisa Furuta, Takane Kikuchi, Shizuo Akira, Naohiro Watanabe, Yasuhiro Yoshikawa

INTERNATIONAL IMMUNOLOGY　Vol. 18　No. 12　p. 1655-1662　2006/12　Research paper (scientific journal)

Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides

Sandra S. Diebold, Catherine Massacrier, Shizuo Akira, Carine Paturel, Yannis Morel, Caetano Reis e Sousa

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 36　No. 12　p. 3256-3267　2006/12　Research paper (scientific journal)

Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.

Devin D. Bolz, Rhianna S. Sundsbak, Ying Ma, Shizuo Akira, John H. Weis, Tom G. Schwan, Janis J. Weis

INFECTION AND IMMUNITY　Vol. 74　No. 12　p. 6750-6760　2006/12　Research paper (scientific journal)

Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling

Ranmal Samarasinghe, Prafullakumar Tailor, Tomohiko Tamura, Tsuneyasu Kaisho, Shizuo Akira, Keiko Ozato

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH　Vol. 26　No. 12　p. 893-900　2006/12　Research paper (scientific journal)

Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade

Min-Kyung Choo, Noritaka Kawasaki, Pattama Singhirunnusorn, Keiichi Koizumi, Shintaro Sato, Shizuo Akira, Ikuo Saiki, Hiroaki Sakurai

Molecular Cancer Therapeutics　Vol. 5　No. 12　p. 2970-2976　2006/12　Research paper (scientific journal)

Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling

Masahiro Yamamoto, Shintaro Sato, Tatsuya Saitoh, Hiroaki Sakurai, Satoshi Uematsu, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira

Journal of Immunology　Vol. 177　No. 11　p. 7520-7524　2006/12/01　Research paper (scientific journal)

VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition

Rabindra N. Bhattacharjee, Kwon Sam Park, Yutaro Kumagai, Kazuhisa Okada, Masahiro Yamamoto, Satoshi Uematsu, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Tetsuya Iida, Takeshi Honda, Osamu Takeuchi, Shizuo Akira

Journal of Biological Chemistry　Vol. 281　No. 48　p. 36897-36904　2006/12/01　Research paper (scientific journal)

5 '-triphosphate RNA is the ligand for RIG-I

Veit Hornung, Jana Ellegast, Sarah Kim, Krzysztof Brzozka, Andreas Jung, Hiroki Kato, Hendrik Poeck, Shizuo Akira, Karl-Klaus Conzelmann, Martin Schlee, Stefan Endres, Gunther Hartmann

SCIENCE　Vol. 314　No. 5801　p. 994-997　2006/11　Research paper (scientific journal)

Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways

Dieudonnee Togbe, Gorse Aurore, Nicolas Noulin, Valerie F. J. Quesniaux, Silvia Schnyder-Candrian, Bruno Schnyder, Virginie Vasseur, Shizuo Akira, Kasper Hoebe, Bruce Beutler, Bernhard Ryffel, Isabelle Couillin

LABORATORY INVESTIGATION　Vol. 86　No. 11　p. 1126-1135　2006/11　Research paper (scientific journal)

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf

Amal Amer, Luigi Franchi, Thirumala-Devi Kanneganti, Mathilde Body-Malapel, Nesrin Ozoren, Graham Brady, Sasha Meshinchi, Rajesh Jagirdar, Andrew Gewirtz, Shizuo Akira, Gabriel Nunez

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 46　p. 35217-35223　2006/11　Research paper (scientific journal)

The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice

M. R. Power, J. S. Marshall, M. Yamamoto, S. Akira, T. J. Lin

Clinical and Experimental Immunology　Vol. 146　No. 2　p. 323-329　2006/11　Research paper (scientific journal)

Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells

Kosuke Matsui, Yutaro Kumagai, Hiroki Kato, Shintaro Sato, Tatsukata Kawagoe, Satoshi Uematsu, Osamu Takeuchi, Shizuo Akira

Journal of Immunology　Vol. 177　No. 9　p. 5785-5789　2006/11/01　Research paper (scientific journal)

Impaired postnatal development in C/EBP β-deficient mice

Tao Bai, Tetsuji Tanaka, Kazunori Yukawa, Naohiko Umesaki, Makoto Matsumoto, Shizuo Akira

Journal of Reproduction and Development　Vol. 52　No. 5　p. 645-649　2006/10　Research paper (scientific journal)

TLR engagement prevents transplantation tolerance

L. Chen, T. Wang, P. Zhou, L. Ma, D. Yin, J. Shen, L. Molinero, T. Nozaki, T. Phillips, S. Uematsu, S. Akira, C. R. Wang, R. L. Fairchild, M. L. Alegre, A. Chong

American Journal of Transplantation　Vol. 6　No. 10　p. 2282-2291　2006/10　Research paper (scientific journal)

Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10

Todd Wuest, Bobbie Ann Austin, Satoshi Uematsu, Manoj Thapa, Shizuo Akira, Daniel J. J. Carr

JOURNAL OF NEUROIMMUNOLOGY　Vol. 179　No. 1-2　p. 46-52　2006/10　Research paper (scientific journal)

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

Shintaro Sato, Hideki Sanjo, Tohru Tsujimura, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Osamu Takeuchi, Shizuo Akira

International Immunology　Vol. 18　No. 10　p. 1405-1411　2006/10　Research paper (scientific journal)

TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation

Hokuto Kamon, Takaya Kawabe, Hidemitsu Kitamura, Jihye Lee, Daisuke Kamimura, Tsuneyasu Kaisho, Shizuo Akira, Akihiro Iwamatsu, Hisashi Koga, Masaaki Murakami, Toshio Hirano

EMBO Journal　Vol. 25　No. 17　p. 4108-4119　2006/09/06　Research paper (scientific journal)

PRRs in pathogen recognition

Satoshi Uematsu, Shizuo Akira

CENTRAL EUROPEAN JOURNAL OF BIOLOGY　Vol. 1　No. 3　p. 299-313　2006/09　Research paper (scientific journal)

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

Karl S. Lang, Panco Georgiev, Mike Recher, Alexander A. Navarini, Andreas Bergthaler, Mathias Heikenwalder, Nicola L. Harris, Tobias Junt, Bernhard Odermatt, Pierre-Alain Clavien, Hanspeter Pircher, Shizuo Akira, Hans Hengartner, Rolf M. Zinkernagel

JOURNAL OF CLINICAL INVESTIGATION　Vol. 116　No. 9　p. 2456-2463　2006/09　Research paper (scientific journal)

Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice

Robert Berland, Luis Fernandez, Elina Kari, Jin-Hwan Han, Ina Lomakin, Shizuo Akira, Henry H. Wortis, John F. Kearney, Angelo A. Ucci, Thereza Imanishi-Kari

IMMUNITY　Vol. 25　No. 3　p. 429-440　2006/09　Research paper (scientific journal)

Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region

Takako Takemiya, Michiyo Maehara, Kiyoshi Matsumura, Shin Yasuda, Hiroko Sugiura, Kanato Yamagata

Neuroscience Research　Vol. 56　No. 1　p. 103-110　2006/09　Research paper (scientific journal)

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways

Wei-Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto, Jun Ninomiya-Tsuji

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 39　p. 28802-28810　2006/09　Research paper (scientific journal)

Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function

Hidemitsu Kitamura, Hideyuki Morikawa, Hokuto Kamon, Megumi Iguchi, Shintaro Hojyo, Toshiyuki Fukada, Susumu Yamashita, Tsuneyasu Kaisho, Shizuo Akira, Masaaki Murakami, Toshio Hirano

NATURE IMMUNOLOGY　Vol. 7　No. 9　p. 971-977　2006/09　Research paper (scientific journal)

Toll-like receptors and innate immunity

Satoshi Uematsu, Shizuo Akira

Journal of Molecular Medicine　Vol. 84　No. 9　p. 712-725　2006/09

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J. Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi, Shizuo Akira

Nature Immunology　Vol. 7　No. 9　p. 962-970　2006/09　Research paper (scientific journal)

Transforming growth factor-β-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis

Koji Sayama, Yasushi Hanakawa, Hiroshi Nagai, Yuji Shirakata, Xiuju Dai, Satoshi Hirakawa, Sho Tokumaru, Mikiko Tohyama, Lujun Yang, Shintaro Sato, Akira Shizuo, Koji Hashimoto

Journal of Biological Chemistry　Vol. 281　No. 31　p. 22013-22020　2006/08/04　Research paper (scientific journal)

Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses

Katja Fink, Karl S. Lang, Nataly Manjarrez-Orduno, Tobias Junt, Beatrice M. Senn, Martin Holdener, Shizuo Akira, Rolf M. Zinkernagel, Hans Hengartner

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 36　No. 8　p. 2094-2105　2006/08　Research paper (scientific journal)

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

Chun-Jen Chen, Yan Shi, Arron Hearn, Kate Fitzgerald, Douglas Golenbock, George Reed, Shizuo Akira, Kenneth L. Rock

JOURNAL OF CLINICAL INVESTIGATION　Vol. 116　No. 8　p. 2262-2271　2006/08　Research paper (scientific journal)

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages

Leesun Kim, Barbara A. Butcher, Chiang W. Lee, Satoshi Uematsu, Shizuo Akira, Eric Y. Denkers

JOURNAL OF IMMUNOLOGY　Vol. 177　No. 4　p. 2584-2591　2006/08　Research paper (scientific journal)

Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury

Yuri Ikeda-Matsuo, Azusa Ota, Tetsuya Fukada, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasaki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 103　No. 31　p. 11790-11795　2006/08　Research paper (scientific journal)

CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation

Ken Shirakawa, Shingo Maeda, Tomomi Gotoh, Makoto Hayashi, Kenichi Shinomiya, Shogo Ehata, Riko Nishimura, Masataka Mori, Kikuo Onozaki, Hidetoshi Hayashi, Satoshi Uematsu, Shizuo Akira, Etsuro Ogata, Kohei Miyazono, Takeshi Imamura

MOLECULAR AND CELLULAR BIOLOGY　Vol. 26　No. 16　p. 6105-6116　2006/08　Research paper (scientific journal)

Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E 2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation

Masaki Inada, Chiho Matsumoto, Satoshi Uematsu, Shizuo Akira, Chisato Miyaura

Journal of Immunology　Vol. 177　No. 3　p. 1879-1885　2006/08/01　Research paper (scientific journal)

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c⁺ lamina propria cells

Satoshi Uematsu, Myoung Ho Jang, Nicolas Chevrier, Zijin Guo, Yutaro Kumagai, Masahiro Yamamoto, Hiroki Kato, Nagako Sougawa, Hidenori Matsui, Hirotaka Kuwata, Hiroaki Hemmi, Cevayir Coban, Taro Kawai, Ken J. Ishii, Osamu Takeuchi, Masayuki Miyasaka, Kiyoshi Takeda, Shizuo Akira

Nature Immunology　Vol. 7　No. 8　p. 868-874　2006/08　Research paper (scientific journal)

TLR8-mediated NF-κB and JNK activation are TAK1-independent and MEKK3-dependent

Jinzhong Qin, Jianhong Yao, Grace Cui, Hui Xiao, Whan Kim Tae, Jerzy Fraczek, Paul Wightman, Shintaro Sato, Shizuo Akira, Anne Puel, Jean-Laurent Casanova, Bing Su, Xiaoxia Li

Journal of Biological Chemistry　Vol. 281　No. 30　p. 21013-21021　2006/07/28　Research paper (scientific journal)

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

Emily Omori, Kunihiro Matsumoto, Hideki Sanjo, Shintaro Sato, Shizuo Akira, Robert C. Smart, Jun Ninomiya-Tsuji

Journal of Biological Chemistry　Vol. 281　No. 28　p. 19610-19617　2006/07/14　Research paper (scientific journal)

Essential role of IPS-1 in innate immune responses against RNA viruses

Himanshu Kumar, Taro Kawai, Hiroki Kato, Shintaro Sato, Ken Takahashi, Cevayir Coban, Masahiro Yamamoto, Satoshi Uematsu, Ken J. Ishii, Osamu Takeuchi, Shizuo Akira

Journal of Experimental Medicine　Vol. 203　No. 7　p. 1795-1803　2006/07/10　Research paper (scientific journal)