Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation

Takaya Ishihara, Reiko Ban-Ishihara, Azusa Ota, Naotada Ishihara

Proceedings of the National Academy of Sciences　Vol. 119　No. 47　2022/11　Research paper (scientific journal)

Multiple assay systems to analyze the dynamics of mitochondrial nucleoids in living mammalian cells.

Takaya Ishihara, Hirotaka Kanon, Reiko Ban-Ishihara, Naotada Ishihara

Biochimica et Biophysica Acta. General Subjects　2021/02　Research paper (scientific journal)

MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.

Yuki Hanada, Naotada Ishihara*(corresponding author), Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, Masatoshi Nomura

Nature Communications　Vol. 11　No. 1　p. 5711-5711　2020/11　Research paper (scientific journal)

Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.

Emi Ogasawara, Kazuto Nakada, Naotada Ishihara

Pharmacological Research　Vol. 160　p. 105204-105204　2020/10　Research paper (scientific journal)

Mitochondrial nucleoid morphology and respiratory function are altered in Drp1-deficient HeLa cells

Azusa Ota, Takaya Ishihara, Naotada Ishihara

Journal of Biochemistry　Vol. 167　No. 3　p. 287-294　2020/03　Research paper (scientific journal)

Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion

Tadato Ban, Hiroto Kohno, Takaya Ishihara, Naotada Ishihara

Biochimica et Biophysica Acta - Bioenergetics　Vol. 1859　No. 9　p. 951-957　2018/09　Research paper (scientific journal)

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

Karen Schmitt, Amandine Grimm, Robert Dallmann, Bjoern Oettinghaus, Lisa Michelle Restelli, Melissa Witzig, Naotada Ishihara, Katsuyoshi Mihara, Jürgen A. Ripperger, Urs Albrecht, Stephan Frank, Steven A. Brown, Anne Eckert

Cell Metabolism　Vol. 27　No. 3　p. 657-666.e5　2018/03　Research paper (scientific journal)

Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.

Tadato Ban, Takaya Ishihara, Hiroto Kohno, Shotaro Saita, Ayaka Ichimura, Katsumi Maenaka, Toshihiko Oka, Katsuyoshi Mihara, Naotada Ishihara

Nature cell biology　Vol. 19　No. 7　p. 856-863　2017/07　Research paper (scientific journal)

Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development

Takaya Ishihara, Reiko Ban-Ishihara, Maki Maeda, Yui Matsunaga, Ayaka Ichimura, Sachiko Kyogoku, Hiroki Aoki, Shun Katada, Kazuto Nakada, Masatoshi Nomura, Noboru Mizushima, Katsuyoshi Mihara, Naotada Ishihara

Molecular and Cellular Biology　Vol. 35　No. 1　p. 211-223　2015　Research paper (scientific journal)

Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles

Osamu Udagawa, Takaya Ishihara, Maki Maeda, Yui Matsunaga, Satoshi Tsukamoto, Natsuko Kawano, Kenji Miyado, Hiroshi Shitara, Sadaki Yokota, Masatoshi Nomura, Katsuyoshi Mihara, Noboru Mizushima, Naotada Ishihara

Current Biology　Vol. 24　No. 20　p. 2451-2458　2014/10/20　Research paper (scientific journal)

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c

Reiko Ban-Ishihara, Takaya Ishihara, Narie Sasaki, Katsuyoshi Mihara, Naotada Ishihara

Proceedings of the National Academy of Sciences of the United States of America　Vol. 110　No. 29　p. 11863-11868　2013/07/16　Research paper (scientific journal)

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

Saori R. Yoshii, Chieko Kishi, Naotada Ishihara, Noboru Mizushima

Journal of Biological Chemistry　Vol. 286　No. 22　p. 19630-19640　2011/06/03　Research paper (scientific journal)

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

Naotada Ishihara, Masatoshi Nomura, Akihiro Jofuku, Hiroki Kato, Satoshi O. Suzuki, Keiji Masuda, Hidenori Otera, Yae Nakanishi, Ikuya Nonaka, Yu Ichi Goto, Naoko Taguchi, Hidetaka Morinaga, Maki Maeda, Ryoichi Takayanagi, Sadaki Yokota, Katsuyoshi Mihara

Nature Cell Biology　Vol. 11　No. 8　p. 958-966　2009　Research paper (scientific journal)

Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission

Naoko Taguchi, Naotada Ishihara, Akihiro Jofuku, Toshihiko Oka, Katsuyoshi Mihara

Journal of Biological Chemistry　Vol. 282　No. 15　p. 11521-11529　2007/04　Research paper (scientific journal)

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

Naotada Ishihara, Yuu Fujita, Toshihiko Oka, Katsuyoshi Mihara

EMBO Journal　Vol. 25　No. 13　p. 2966-2977　2006/07/12　Research paper (scientific journal)

Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space

Hidenori Otera, Shigenori Ohsakaya, Zen Ichiro Nagaura, Naotada Ishihara, Katsuyoshi Mihara

EMBO Journal　Vol. 24　No. 7　p. 1375-1386　2005/04　Research paper (scientific journal)

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae

Akio Kihara, Takeshi Noda, Naotada Ishihara, Yoshinori Ohsumi

Journal of Cell Biology　Vol. 153　No. 3　p. 519-530　2001/04　Research paper (scientific journal)

Autophagosome requires specific early sec proteins for its formation and NSF/SNARE for vacuolar fusion

N. Ishihara, M. Hamasaki, S. Yokota, K. Suzuki, Y. Kamada, A. Kihara, T. Yoshimori, T. Noda, Y. Ohsumi

Molecular Biology of the Cell　Vol. 12　No. 11　p. 3690-3702　2001　Research paper (scientific journal)

A ubiquitin-like system mediates protein lipidation

Yoshinobu Ichimura, Takayoshi Kirisako, Toshifumi Takao, Yoshinori Satomi, Yasutsugu Shimonishi, Naotada Ishihara, Noboru Mizushima, Isei Tanida, Eiki Kominami, Mariko Ohsumi, Takeshi Noda, Yoshinori Ohsumi

Nature　Vol. 408　No. 6811　p. 488-492　2000/11/23　Research paper (scientific journal)

Formation process of autophagosome is traced with Apg8/Aut7p in yeast

Takayoshi Kirisako, Misuzu Baba, Naotada Ishihara, Kouichi Miyazawa, Mariko Ohsumi, Tamotsu Yoshimori, Takeshi Noda, Yoshinori Ohsumi

Journal of Cell Biology　Vol. 147　No. 2　p. 435-446　1999　Research paper (scientific journal)

Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7

Haruna Harada, Koko Moriya, Hirotsugu Kobuchi, Naotada Ishihara, Toshihiko Utsumi

Scientific Reports　Vol. 13　No. 1　2023/12　Research paper (scientific journal)

Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes

Kaori Hozumi, Kenji Sugawara, Takaya Ishihara, Naotada Ishihara, Wataru Ogawa

Scientific Reports　Vol. 13　No. 1　p. 746-746　2023/12　Research paper (scientific journal)

Genetic defects in peroxisome morphogenesis (Pex11β, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism

Yuichi Abe, Ronald J.A. Wanders, Hans R. Waterham, Hanna Mandel, Tzipora C. Falik-Zaccai, Naotada Ishihara, Yukio Fujiki

Journal of Inherited Metabolic Disease　Vol. 46　No. 2　p. 273-285　2023/03　Research paper (scientific journal)

Pearson syndrome-like anemia induced by accumulation of mutant mtDNA and anemia with imbalanced white blood cell lineages induced by Drp1 deletion in a murine model.

Kaori Ishikawa, Yo Honma, Ayami Yoshimi, Shun Katada, Takaya Ishihara, Naotada Ishihara, Kazuto Nakada

Pharmacological research　Vol. 185　p. 106467-106467　2022/09　Research paper (scientific journal)

Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism

Kaori Fukui, Tomoyuki Takahashi, Hitomi Matsunari, Ayuko Uchikura, Masahito Watanabe, Hiroshi Nagashima, Naotada Ishihara, Tatsuyuki Kakuma, Yoriko Watanabe, Yushiro Yamashita, Makoto Yoshino

Journal of Inherited Metabolic Disease　2022/08　Research paper (scientific journal)

Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status

Themis Thoudam, Dipanjan Chanda, Ibotombi Singh Sinam, Byung-Gyu Kim, Mi-Jin Kim, Chang Joo Oh, Jung Yi Lee, Min-Ji Kim, Soo Yeun Park, Shin Yup Lee, Min-Kyo Jung, Ji Young Mun, Robert A. Harris, Naotada Ishihara, Jae-Han Jeon, In-Kyu Lee

Proceedings of the National Academy of Sciences　Vol. 119　No. 34　2022/08　Research paper (scientific journal)

Inhibition of mitochondrial fission protects podocytes from albumin-induced cell damage in diabetic kidney disease.

Makoto Tagaya, Shinji Kume, Mako Yasuda-Yamahara, Shogo Kuwagata, Kosuke Yamahara, Naoko Takeda, Yuki Tanaka, Masami Chin-Kanasaki, Yuki Nakae, Hideki Yokoi, Masashi Mukoyama, Naotada Ishihara, Masatoshi Nomura, Shin-Ichi Araki, Hiroshi Maegawa

Biochimica et Biophysica Acta. Molecular Basis of Disease　Vol. 1868　No. 5　p. 166368-166368　2022/05　Research paper (scientific journal)

Dynamin Related Protein 1 Differentially Regulates FcεRI- and SP-induced Mast Cell Activation.

Ying Wang, Mang Yu, Kazufumi Matsushita, Chen Liu, Naotada Ishihara, Masatoshi Nomura, Mindy Tsai, Stephen J Galli

The Journal of Allergy and Clinical Immunology　2022/05　Research paper (scientific journal)

Molecular mechanism linking metabolism and innate immunity on mitochondria

Yuki Hanada, Takaya Ishihara, Naotada Ishihara

Seikagaku　Vol. 94　No. 2　p. 230-235　2022　Research paper (scientific journal)

Frontiers and new trends in mitochondrial research: Dynamic behavior of key players in metabolic control, and its application to drug discovery

Masamichi Yamamoto, Naotada Ishihara

Seikagaku　Vol. 94　No. 2　p. 157-158　2022　Research paper (scientific journal)

Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

Seiya Yamada, Ayaka Sato, Naotada Ishihara, Hiroki Akiyama, Shin-ichi Sakakibara

iScience　Vol. 24　No. 12　p. 103484-103484　2021/12　Research paper (scientific journal)

Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor.

Yukina Takeichi, Takashi Miyazawa, Shohei Sakamoto, Yuki Hanada, Lixiang Wang, Kazuhito Gotoh, Keiichiro Uchida, Shunsuke Katsuhara, Ryuichi Sakamoto, Takaya Ishihara, Keiji Masuda, Naotada Ishihara, Masatoshi Nomura, Yoshihiro Ogawa

Diabetologia　Vol. 64　No. 9　p. 2092-2107　2021/05　Research paper (scientific journal)

Analysis of mitochondrial membrane fusion gtpase opa1 expressed by the silkworm expression system

Tadato Ban, Naotada Ishihara

Methods in Molecular Biology　Vol. 2159　p. 115-127　2020/06　Part of collection (book)

Mitochondrial dynamics and interorganellar communication in the development and dysmorphism of mammalian oocytes

Osamu Udagawa, Naotada Ishihara

Journal of Biochemistry　Vol. 167　No. 3　p. 257-266　2020/03

Mitochondrial hyperfusion causes neuropathy in a fly model of CMT2A

Eri Ueda, Naotada Ishihara

EMBO Reports　Vol. 19　No. 8　2018/08　Research paper (scientific journal)

Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner.

Yoshihiro Miyazono, Shingo Hirashima, Naotada Ishihara, Jingo Kusukawa, Kei-Ichiro Nakamura, Keisuke Ohta

Scientific reports　Vol. 8　No. 1　p. 350-350　2018/01　Research paper (scientific journal)

Cell-free mitochondrial fusion assay detected by specific protease reaction revealed Ca2+ as regulator of mitofusin-dependent mitochondrial fusion.

Naotada Ishihara, Maki Maeda, Tadato Ban, Katsuyoshi Mihara

Journal of biochemistry　Vol. 162　No. 4　p. 287-294　2017/10　Research paper (scientific journal)

Three-dimensional analysis of somatic mitochondrial dynamics in fission-deficient injured motor neurons using FIB/SEM.

Hiromi Tamada, Sumiko Kiryu-Seo, Hiroki Hosokawa, Keisuke Ohta, Naotada Ishihara, Masatoshi Nomura, Katsuyoshi Mihara, Kei-Ichiro Nakamura, Hiroshi Kiyama

The Journal of comparative neurology　Vol. 525　No. 11　p. 2535-2548　2017/08　Research paper (scientific journal)

Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells.

Haruka Iihoshi, Takaya Ishihara, Shogo Kuroda, Naotada Ishihara, Hisato Saitoh

Toxicology letters　Vol. 277　p. 109-114　2017/08　Research paper (scientific journal)

Expression and purification of recombinant human L-OPA1 using BmNPV bacmid-silkworm expression system.

T. Ban, N. Ishihara

Protoc. Exch.　2017/06　Research paper (scientific journal)

D-Glutamate is metabolized in the heart mitochondria.

Makoto Ariyoshi, Masumi Katane, Kenji Hamase, Yurika Miyoshi, Maiko Nakane, Atsushi Hoshino, Yoshifumi Okawa, Yuichiro Mita, Satoshi Kaimoto, Motoki Uchihashi, Kuniyoshi Fukai, Kazunori Ono, Syuhei Tateishi, Daichi Hato, Ryoetsu Yamanaka, Sakiko Honda, Yohei Fushimura, Eri Iwai-Kanai, Naotada Ishihara, Masashi Mita, Hiroshi Homma, Satoaki Matoba

Scientific reports　Vol. 7　p. 43911-43911　2017/03/07　Research paper (scientific journal)

PARL paves the way to apoptosis.

Naotada Ishihara, Katsuyoshi Mihara

Nature cell biology　Vol. 19　No. 4　p. 263-265　2017/03　Research paper (scientific journal)

Mitochondrial fission is an acute and adaptive response in injured motor neurons.

Sumiko Kiryu-Seo, Hiromi Tamada, Yukina Kato, Katsura Yasuda, Naotada Ishihara, Masatoshi Nomura, Katsuyoshi Mihara, Hiroshi Kiyama

Scientific reports　Vol. 6　p. 28331-28331　2016/06　Research paper (scientific journal)

Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission

Shotaro Saita, Takaya Ishihara, Maki Maeda, Shun ichiro Iemura, Tohru Natsume, Katsuyoshi Mihara, Naotada Ishihara

Genes to Cells　Vol. 21　No. 5　p. 408-424　2016/05/01　Research paper (scientific journal)

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

B. Oettinghaus, J. M. Schulz, L. M. Restelli, M. Licci, C. Savoia, A. Schmidt, K. Schmitt, A. Grimm, L. Morè, J. Hench, M. Tolnay, A. Eckert, P. D'adamo, P. Franken, N. Ishihara, K. Mihara, J. Bischofberger, L. Scorrano, S. Frank

Cell Death and Differentiation　Vol. 23　No. 1　p. 18-28　2016/01/01　Research paper (scientific journal)

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

Lixiang Wang, Takaya Ishihara, Yuta Ibayashi, Keita Tatsushima, Daiki Setoyama, Yuki Hanada, Yukina Takeichi, Shohei Sakamoto, Sadaki Yokota, Katsuyoshi Mihara, Dongchon Kang, Naotada Ishihara, Ryoichi Takayanagi, Masatoshi Nomura

Diabetologia　Vol. 58　No. 10　p. 2371-2380　2015/10/24　Research paper (scientific journal)

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1

Reiko Ban-Ishihara, Shiho Tomohiro-Takamiya, Motohiro Tani, Jacques Baudier, Naotada Ishihara, Osamu Kuge

FEBS Letters　Vol. 589　No. 20　p. 3126-3132　2015/10/07　Research paper (scientific journal)

CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

Arezu Jahani-Asl, En Huang, Isabella Irrcher, Juliet Rashidian, Naotada Ishihara, Diane C. Lagace, Ruth S. Slack, David S. Park

Human Molecular Genetics　Vol. 24　No. 16　p. 4573-4583　2015/04　Research paper (scientific journal)

A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division

Kohei Arasaki, Hiroaki Shimizu, Hirofumi Mogari, Naoki Nishida, Naohiko Hirota, Akiko Furuno, Yoshihisa Kudo, Misuzu Baba, Norio Baba, Jinglei Cheng, Toyoshi Fujimoto, Naotada Ishihara, Carolina Ortiz-Sandoval, Lael D. Barlow, Arun Raturi, Naoshi Dohmae, Yuichi Wakana, Hiroki Inoue, Katsuko Tani, Joel B. Dacks, Thomas Simmen, Mitsuo Tagaya

Developmental Cell　Vol. 32　No. 3　p. 304-317　2015/02　Research paper (scientific journal)

Physiological roles of mitochondrial fission in cultured cells and mouse development

Takaya Ishihara, Hiroto Kohno, Naotada Ishihara

Annals of the New York Academy of Sciences　Vol. 1350　No. 1　p. 77-81　2015　Research paper (scientific journal)

Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in Mammals

Naotada Ishihara, Hidenori Otera, Toshihiko Oka, Katsuyoshi Mihara

Antioxidants and Redox Signaling　Vol. 19　No. 4　p. 389-399　2013/08/01

Mitochondria-type GPAT is required for mitochondrial fusion

Yohsuke Ohba, Takeshi Sakuragi, Eriko Kage-Nakadai, Naoko H. Tomioka, Nozomu Kono, Rieko Imae, Asuka Inoue, Junken Aoki, Naotada Ishihara, Takao Inoue, Shohei Mitani, Hiroyuki Arai

EMBO Journal　Vol. 32　No. 9　p. 1265-1279　2013/05/02　Research paper (scientific journal)

New insights into the function and regulation of mitochondrial fission

Hidenori Otera, Naotada Ishihara, Katsuyoshi Mihara

Biochimica et Biophysica Acta - Molecular Cell Research　Vol. 1833　No. 5　p. 1256-1268　2013/05

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

Kenta Onoue, Akihiro Jofuku, Reiko Ban-Ishihara, Takaya Ishihara, Maki Maeda, Takumi Koshiba, Takashi Itoh, Mitsunori Fukuda, Hidenori Otera, Toshihiko Oka, Hiroyoshi Takano, Noboru Mizushima, Katsuyoshi Mihara, Naotada Ishihara

Journal of Cell Science　Vol. 126　No. 1　p. 176-185　2013/01/01　Research paper (scientific journal)

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5

Shiori Sekine, Yusuke Kanamaru, Masato Koike, Ayako Nishihara, Masahiro Okada, Hideyuki Kinoshita, Miki Kamiyama, Junichi Maruyama, Yasuo Uchiyama, Naotada Ishihara, Kohsuke Takeda, Hidenori Ichijo

Journal of Biological Chemistry　Vol. 287　No. 41　p. 34635-34645　2012/10/05　Research paper (scientific journal)

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

Anoop Kumar G. Velikkakath, Taki Nishimura, Eiko Oita, Naotada Ishihara, Noboru Mizushima

Molecular Biology of the Cell　Vol. 23　No. 5　p. 896-909　2012/03/01　Research paper (scientific journal)

Mitofusin 2 inhibits mitochondrial antiviral signaling

Kai Yasukawa, Hiroyuki Oshiumi, Makoto Takeda, Naotada Ishihara, Yusuke Yanagi, Tsukasa Seya, Shun Ichiro Kawabata, Takumi Koshiba

Science Signaling　Vol. 2　No. 84　2009/08/18　Research paper (scientific journal)

A Receptor for Eating Mitochondria

Naotada Ishihara, Noboru Mizushima

Developmental Cell　Vol. 17　No. 1　p. 1-2　2009/07/21

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L

Shoko Tamai, Hiroshi Iida, Sadaki Yokota, Tomoko Sayano, Shoko Kiguchiya, Naotada Ishihara, Jun Ichi Hayashi, Katsuyoshi Mihara, Toshihiko Oka

Journal of Cell Science　Vol. 121　No. 15　p. 2588-2600　2008/08/01　Research paper (scientific journal)

Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function

Yuka Eura, Naotada Ishihara, Toshihiko Oka, Katsuyoshi Mihara

Journal of Cell Science　Vol. 119　No. 23　p. 4913-4925　2006/12/01　Research paper (scientific journal)

Mitochondrial fusion and fission in mammalian cells

Naotada Ishihara, Katsuyoshi Mihara

Tanpakushitsu kakusan koso, Protein, nucleic acid, enzyme　Vol. 50　No. 14 Suppl　p. 1868-1871　2005/11

Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein

Akihiro Jofuku, Naotada Ishihara, Katsuyoshi Mihara

Biochemical and Biophysical Research Communications　Vol. 333　No. 2　p. 650-659　2005/07/29　Research paper (scientific journal)

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

Naotada Ishihara, Yuka Eura, Katsuyoshi Mihara

Journal of Cell Science　Vol. 117　No. 26　p. 6535-6546　2004/12/15　Research paper (scientific journal)

Two Mitofusin Proteins, Mammalian Homologues of FZO, with Distinct Functions Are Both Required for Mitochondrial Fusion

Yuka Eura, Naotada Ishihara, Sadaki Yokota, Katsuyoshi Mihara

Journal of Biochemistry　Vol. 134　No. 3　p. 333-344　2003/09　Research paper (scientific journal)

Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells

Naotada Ishihara, Akihiro Jofuku, Yuka Eura, Katsuyoshi Mihara

Biochemical and Biophysical Research Communications　Vol. 301　No. 4　p. 891-898　2003/02/21　Research paper (scientific journal)

Formation of the ∼350-kDa Apg12-Apg5·Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast

Akiko Kuma, Noboru Mizushima, Naotada Ishihara, Yoshinori Ohsumi

Journal of Biological Chemistry　Vol. 277　No. 21　p. 18619-18625　2002/05/24　Research paper (scientific journal)

Mammalian mitochondrial endonuclease G: Digestion of R-loops and localization in intermembrane space

Takashi Ohsato, Naotada Ishihara, Tsuyoshi Muta, Shuyo Umeda, Shogo Ikeda, Katsuyoshi Mihara, Naotaka Hamasaki, Dongchon Kang

European Journal of Biochemistry　Vol. 269　No. 23　p. 5765-5770　2002　Research paper (scientific journal)

Characterization of the initial steps of precursor import into rat liver mitoplasts

Naotada Ishihara, Tohru Komiya, Masao Sakaguchi, Akio Ito, Katsuyoshi Mihara

Journal of Biochemistry　Vol. 124　No. 4　p. 824-834　1998/10　Research paper (scientific journal)

Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44

Naotada Ishihara, Katsuyoshi Mihara

Journal of Biochemistry　Vol. 123　No. 4　p. 722-732　1998/04　Research paper (scientific journal)

Malfolded cytochrome P-450(M1) localized in unusual membrane structures of the endoplasmic reticulum in cultured animal cells

Naotada Ishihara, Shohei Yamashine, Masao Sakaguchi, Katsuyoshi Mihara, Tsuneo Omura

Journal of Biochemistry　Vol. 118　No. 2　p. 397-404　1995/08　Research paper (scientific journal)