Infusion-Related Reactions Subsequent to Avelumab, Durvalumab, and Atezolizumab Administration: A Retrospective Observational Study.

Keiko Hata, Keina Nakamura, Shinichiro Maeda, Makiko Maeda, Yasushi Fujio, Sachiko Hirobe

Clinics and practice　Vol. 14　No. 2　p. 377-387　2024/02/23　Research paper (scientific journal)

抗IL-6受容体抗体およびJAK阻害剤がSARS-CoV-2感染後腎障害に与える影響解明 非臨床モデルを用いた解析

禿 宏保, 尾花 理徳, 坂井 響, 徳納 渚沙, 山本 彩葉, 田中 翔大, 岡田 欣晃, 吉岡 靖雄, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 2-2　2024/01

心筋梗塞後炎症反応を治療標的とした脂質メディエーターの探索

森 翔太, 田中 翔大, 岡田 欣晃, 尾花 理徳, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 3-2　2024/01

新生仔ラット心筋細胞において、脱分化マーカーRunx1は心筋細胞の幼若化と増殖を促進する

鈴木 翔大, 亀谷 祐介, 梅田 綾香, 西中 康介, 江川 果穂, 田中 翔大, 岡田 欣晃, 尾花 理徳, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 3-2　2024/01

成体マウス心臓において、YAPの活性化は、心筋炎による組織傷害からの修復に必須である

梅田 綾香, 亀谷 祐介, 鈴木 翔大, 西中 康介, 江川 果穂, 田中 翔大, 岡田 欣晃, 尾花 理徳, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 3-3　2024/01

糸球体構成細胞ポドサイトにおけるGARPは糸球体硬化病変に関与する

池田 明花理, 尾花 理徳, 山本 彩葉, 坂井 響, 田中 翔大, 岡田 欣晃, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 3-4　2024/01

血管透過性制御能を有する薬物治療標的分子Robo4が血管部位特異的に発現するメカニズムの解明

正木 辰実, 米田 安希, 渡部 秀一, ブラウン・トーマス, 深田 宗一朗, 藤尾 慈, 岡田 欣晃

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 1-J1　2024/01

線維化疾患に対する遺伝子治療法の確立に向けた線維芽細胞の血管内皮細胞への高効率転換技術の開発

前田 星, 神原 知明, 井澤 洸栄, 土井 健史, 藤尾 慈, 岡田 欣晃

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 2-J4　2024/01

血管透過性抑制分子Robo4の発現を促進する重症感染症治療薬の開発

森田 真綾, 米田 安希, 徳納 渚沙, 正木 辰実, 橋本 里菜, 高山 和雄, 吉岡 靖雄, 藤尾 慈, 岡田 欣晃

日本臨床薬理学会学術総会抄録集　Vol. 44回　p. 3-H1　2024/01

Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study.

Makiko Maeda, Douglas Humber, Eisuke Hida, Tomohito Ohtani, Guannan Wang, Tong Wu, Shiori Takeda, Jacinta N Situ, Jun Hayashi, Shinpei Nonen, Toshihiro Takeda, Hiroshi Okamoto, Masatsugu Hori, Yasushi Sakata, Yasushi Fujio, Shirley M Tsunoda

PloS one　Vol. 19　No. 3　2024　Research paper (scientific journal)

Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model.

Tomoki Sakata, Hiroki Kohno, Tomohiko Inui, Hiroki Ikeuchi, Yuki Shiko, Yohei Kawasaki, Shota Suzuki, Shota Tanaka, Masanori Obana, Kiyotake Ishikawa, Yasushi Fujio, Goro Matsumiya

European journal of pharmacology　Vol. 961　p. 176145-176145　2023/12/15　Research paper (scientific journal)

Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes.

Shota Suzuki, Shota Tanaka, Yusuke Kametani, Ayaka Umeda, Kosuke Nishinaka, Kaho Egawa, Yoshiaki Okada, Masanori Obana, Yasushi Fujio

Physiological reports　Vol. 11　No. 23　2023/12　Research paper (scientific journal)

脈管と周囲組織とを結ぶ多彩な生命科学 血管透過性を標的とする重症感染症治療薬の開発

岡田 欣晃, 高山 和雄, 吉岡 靖雄, 近藤 昌夫, 藤尾 慈

日本生化学会大会プログラム・講演要旨集　Vol. 96回　p. [3S09e-02]　2023/10

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

Maaya Morita, Aki Yoneda, Nagisa Tokunoh, Tatsumi Masaki, Keisuke Shirakura, Mayumi Kinoshita, Rina Hashimoto, Naoya Shigesada, Junya Takahashi, Masashi Tachibana, Shota Tanaka, Masanori Obana, Nobumasa Hino, Masahito Ikawa, Kazutake Tsujikawa, Chikako Ono, Yoshiharu Matsuura, Hiroyasu Kidoya, Nobuyuki Takakura, Yoshiaki Kubota, Takefumi Doi, Kazuo Takayama, Yasuo Yoshioka, Yasushi Fujio, Yoshiaki Okada

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 3　2023/01/17　Research paper (scientific journal)

Warfarin投与量予測モデルにおけるPT-INR欠測値補完方法の探索

弓場 遼真, 齊藤 茉莉佳, 前田 真一郎, 廣部 祥子, 藤尾 慈, 前田 真貴子

日本臨床薬理学会学術総会抄録集　Vol. 44　2023

大規模医療情報データベースを用いた日本における降圧薬の有害事象発現状況の調査

細美 友里瑛, 前田 真貴子, 廣部 祥子, 前田 真一郎, 神出 計, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44　2023

慢性心不全患者における高齢がβ- blockerの投与量、有効性及び安全性に及ぼす影響に関する調査

武田 汐莉, 六車 萌恵, 前田 真一郎, 廣部 祥子, 藤尾 慈, 前田 真貴子

日本臨床薬理学会学術総会抄録集　Vol. 44　2023

TGF-β3は骨髄細胞のM2マクロファージへの分化を抑制する

小南 春祐, 冨松 聖史, 梶浦 僚太, 田中 翔大, 岡田 欣晃, 尾花 理徳, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 44　2023

Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury.

Koki Tanaka, Hiroki Harada, Hiroyasu Kamuro, Hibiki Sakai, Ayaha Yamamoto, Masashi Tomimatsu, Akari Ikeda, Renya Chosokabe, Shota Tanaka, Yoshiaki Okada, Yasushi Fujio, Masanori Obana

Biological & pharmaceutical bulletin　Vol. 46　No. 12　p. 1753-1760　2023　Research paper (scientific journal)

Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice.

Zhiqi Xie, Haoyang Zhou, Masanori Obana, Yasushi Fujio, Naoki Okada, Masashi Tachibana

Frontiers in immunology　Vol. 14　p. 1243851-1243851　2023　Research paper (scientific journal)

LVAD装着患者におけるワルファリン維持投与量決定と遺伝子多型およびアミオダロン投与量の関連

齊藤 茉莉佳, 前田 真貴子, 牧口 実咲, 伊藤 仁人, 世良 英子, 佐村 高明, 大谷 朋仁, 吉岡 大輔, 宮川 繁, 坂田 泰史, 藤尾 慈

日本臨床薬理学会学術総会抄録集　Vol. 43回　p. 1-4　2022/12

Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling

Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio

Scientific Reports　Vol. 12　No. 1　2022/12　Research paper (scientific journal)

Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis

Yoshiaki Miyake, Masanori Obana, Ayaha Yamamoto, Shunsuke Noda, Koki Tanaka, Hibiki Sakai, Narihito Tatsumoto, Chihiro Makino, Soshi Kanemoto, Go Shioi, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Kazunori Imaizumi, Katsuhiko Asanuma, Yasushi Fujio

Communications Biology　Vol. 5　No. 1　2022/12　Research paper (scientific journal)

Identification of biomarkers of chronic kidney disease among kidney-derived proteins

Kazuma Higashisaka, Sonoko Takeya, Haruhiko Kamada, Masanori Obana, Makiko Maeda, Mai Kabayama, Koichi Yamamoto, Nanan Ishida, Ryo Isaka, Hirofumi Tsujino, Kazuya Nagano, Noriyuki Tomiyama, Hiromi Rakugi, Yasushi Fujio, Kei Kamide, Yasuo Tsutsumi

Clinical Proteomics　Vol. 19　No. 1　p. 3-3　2022/12　Research paper (scientific journal)

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka, Masato Tanaka, Tomoaki Kanbara, Shota Tanaka, Shigeyuki Tamiya, Nagisa Tokunoh, Atsushi Kawai, Masahito Ikawa, Chikako Ono, Keisuke Tachibana, Masuo Kondoh, Masanori Obana, Yoshiharu Matsuura, Akihiro Ohsumi, Takeshi Noda, Takuya Yamamoto, Yasuo Yoshioka, Yu-Suke Torisawa, Hiroshi Date, Yasushi Fujio, Miki Nagao, Kazuo Takayama, Yoshiaki Okada

Science advances　Vol. 8　No. 38　2022/09/23　Research paper (scientific journal)

Safety evaluation of MA-T after ingestion in mice.

Takahiro Noguchi, Keisuke Tachibana, Tsuyoshi Inoue, Takayoshi Sakai, Kazutake Tsujikawa, Yasushi Fujio, Yoshiaki Yamagishi, Shigeto Hamaguchi, Satoshi Kutsuna, Masuo Kondoh

Toxicology　Vol. 477　p. 153254-153254　2022/07　Research paper (scientific journal)

Glycoprotein 130 orchestrates signal transduction network to promote cardiomyocyte proliferation for normal growth

Masanori Obana, Makiko Maeda, Yasushi Fujio

American Journal of Physiology-Heart and Circulatory Physiology　Vol. 323　No. 1　p. H125-H127　2022/07/01　Research paper (scientific journal)

CXCL10 is a novel anti-angiogenic factor downstream of p53 in cardiomyocytes.

Tri Wahyuni, Shota Tanaka, Ryuta Igarashi, Yoshiaki Miyake, Ayaha Yamamoto, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Shota Suzuki, Kosei Yokota, Yoshiaki Okada, Makiko Maeda, Masanori Obana, Yasushi Fujio

Physiological reports　Vol. 10　No. 9　2022/05　Research paper (scientific journal)

Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes and heart failure with preserved ejection fraction: The EXCEED randomized controlled multicenter study.

Hiroshi Akasaka, Ken Sugimoto, Ayumi Shintani, Satsuki Taniuchi, Koichi Yamamoto, Katsuomi Iwakura, Atsunori Okamura, Shin Takiuchi, Masahiro Fukuda, Kei Kamide, Yasushi Fujio, Satoshi Nakatani, Toshio Ogihara, Hiromi Rakugi

Geriatrics & gerontology international　Vol. 22　No. 4　p. 298-304　2022/04　Research paper (scientific journal)

Yes‐associated protein activation potentiates glycogen synthase kinase‐3 inhibitor‐induced proliferation of neonatal cardiomyocytes and iPS cell‐derived cardiomyocytes

Yusuke Kametani, Shota Tanaka, Yuriko Wada, Shota Suzuki, Ayaka Umeda, Kosuke Nishinaka, Yoshiaki Okada, Makiko Maeda, Shigeru Miyagawa, Yoshiki Sawa, Masanori Obana, Yasushi Fujio

Journal of Cellular Physiology　Vol. 237　No. 5　p. 2539-2549　2022/03/21　Research paper (scientific journal)

血管安定化分子Robo4の発現を変化させ血管透過性を制御する低分子化合物の探索

岡田 欣晃, 木下 真由美, 白倉 圭佑, 樫尾 泰斗, 村岡 康介, 藤尾 慈, 土井 健史

日本内分泌学会雑誌　Vol. 97　No. 5　p. 1519-1519　2022/03

Claudinopathyの基盤研究 Clauidin-5と肺疾患

若山 英里香, 橘 敬祐, 橋本 洋祐, 平山 龍一, 谷 里奈, 國安 弘基, 竹田 浩之, 岡田 欣晃, 藤尾 慈, 近藤 昌夫

日本薬学会年会要旨集　Vol. 142年会　p. 28PO2-02S　2022/03

血管透過性を標的とする新戦略での疾患治療 血管透過性を標的とする新戦略での重症感染症・炎症疾患治療薬の開発

岡田 欣晃, 土井 健史, 藤尾 慈

日本薬学会年会要旨集　Vol. 142年会　p. S23-1　2022/03

多様な臓器から考える線維化治療への最先端アプローチ 線維症治療に資する線維芽細胞の血管内皮細胞への転換技術の開発

神原 知明, 井澤 洸栄, 土井 健史, 藤尾 慈, 岡田 欣晃

日本薬学会年会要旨集　Vol. 142年会　p. GS02-4　2022/03

アテゾリズマブの投与により早期に発現する副作用およびその発現に関連する因子の調査

秦 啓子, 中村 圭菜, 犬飼 萌乃, 前田 真一郎, 前田 真貴子, 藤尾 慈, 廣部 祥子

日本臨床薬理学会学術総会抄録集　Vol. 43　2022

Increased OASIS in podocytes contributes to the disruption of kidney homeostasis

Miyake Yoshiaki, Obana Masanori, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Imaizumi Kazunori, Asanuma Katsuhiko, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022　Research paper (other academic)

IL-6 family cytokines, STAT3 activators, exhibit differential effects in a ligand-specific manner in podocytes

Sayuri Mitsuoka, Obana Masanori, Miyake Yoshiaki, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022　Research paper (other academic)

TGFβ3 exacerbates myocardial remodeling after myocardial infarction.

Tomimatsu Masashi, Yokota Kosei, Kominami Shunsuke, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022　Research paper (other academic)

Leupaxin is upregulated in fibrotic kidneys and contributes to the proliferation of kidney fibroblasts

Noda Shunsuke, Obana Masanori, Miyake Yoshiaki, Yamamoto Ayaha, Tanaka Shota, Maeda Makiko, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 95　2022　Research paper (other academic)

Establishment of a novel method for analysis of biological functions of myeloid cell subpopulation in cardiovascular diseases using TRECK system.

Yokota Kosei, Tomimatsu Masashi, Kominami Shunsuke, Kajiura Ryota, Tanaka Shota, Obana Masanori, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 96　2022　Research paper (other academic)

Runx1 is upregulated by STAT3 and promotes cell proliferation in neonatal rat cardiomyocytes.

Shota Suzuki, Kametani Yusuke, Umeda Ayaka, Nishinaka Kosuke, Tanaka Shota, Obana Masanori, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 96　2022　Research paper (other academic)

PAI-1 induction is a critical event for the onset of lipopolysaccharide-induced acute kidney injury.

Koki Tanaka, Obana Masanori, Sakai Hibiki, Kamuro Hiroyasu, Yamamoto Ayaha, Tanaka Syota, Okada Yoshiaki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 96　2022　Research paper (other academic)

PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis.

Yoshiaki Miyake, Masanori Obana, Takafumi Nakae, Ayaha Yamamoto, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Yasushi Fujio

Biochemical and biophysical research communications　Vol. 571　p. 88-95　2021/09/24　Research paper (scientific journal)

Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway.

Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio

American journal of physiology. Cell physiology　Vol. 321　No. 1　2021/07/01　Research paper (scientific journal)

Title: Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases

Takafumi Nakae, Masanori Obana, Takahiro Maeda, Akari Ikeda, Hiroshi Miyazaki, Shota Tanaka, Makiko Maeda, Kunihiko Yamashita, Kazuhiro Terai, Satoshi Obika, Yasushi Fujio

Gene　Vol. 788　p. 145664-145664　2021/07　Research paper (scientific journal)

ポドサイトの転写因子OASISは腎病態進展に寄与する

三宅 芳明, 尾花 理徳, 山本 彩葉, 田中 翔大, 前田 真貴子, 今泉 和則, 淺沼 克彦, 藤尾 慈

日本腎臓学会誌　Vol. 63　No. 4　p. 499-499　2021/06

Adenovirus Vector–Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Ryosuke Ono, Tomohito Tsukamoto, Fumitaka Nishimae, Shin-ichiro Nakamura, Toru Nishinaka, Tomoyuki Terada, Yasushi Fujio, Hiroyuki Mizuguchi

The Journal of Immunology　Vol. 206　No. 2　p. 410-421　2021/01/15　Research paper (scientific journal)

Activation of YAP is essential for the myocardial recovery from myocarditis

Fukuyama Shoki, Kametani Yusuke, Wada Yuriko, Suzuki Shota, Umeda Ayaka, Maeda Makiko, Tanaka Shota, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Acute kidney injury-induced ZBTB38 contributes to tubular cell loss.

Harada Takeo, Obana Masanori, Miyake Yosiaki, Yamamoto Ayaha, Kamuro Hiroyasu, Tanaka Syota, Maeda Makiko, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Establishment of a novel experimental autoimmune vasculitis model

Seo Takafumi, Tanaka Shota, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Cardioprotective roles of novel cell death inhibitor, defender against cell death 1 (Dad1)

Mori Shota, Tanaka Shota, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

CXCL10 is an anti-angiogenic factor downstream of p53 in cardiomyocytes.

Igarashi Ryuta, Tomimatsu Masashi, Maeda Makiko, Tanaka Syota, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 94　2021

Vascular Endothelial Growth Factor Receptor Inhibitors Impair Left Ventricular Diastolic Functions.

Haruka Yokoyama, Wataru Shioyama, Takuya Shintani, Shinichiro Maeda, Sachiko Hirobe, Makiko Maeda, Yasushi Sakata, Yasushi Fujio

International heart journal　Vol. 62　No. 6　p. 1297-1304　2021　Research paper (scientific journal)

Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis.

Ayaha Yamamoto, Hitomi Morioki, Takafumi Nakae, Yoshiaki Miyake, Takeo Harada, Shunsuke Noda, Sayuri Mitsuoka, Kotaro Matsumoto, Masashi Tomimatsu, Soshi Kanemoto, Shota Tanaka, Makiko Maeda, Simon J Conway, Kazunori Imaizumi, Yasushi Fujio, Masanori Obana

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 35　No. 2　2020/11/05　Research paper (scientific journal)

Thorough QT/QTc Study Shows That a Novel 5-HT4 Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation.

Tatsuto Hamatani, Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Hirotaka Kawai, Hiroyoshi Kakuyama, Yoshikazu Kaji, Yasushi Fujio

Clinical pharmacology in drug development　Vol. 9　No. 8　p. 938-951　2020/11　Research paper (scientific journal)

β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.

Shota Tanaka, Atsuki Imaeda, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio

Pharmacology research & perspectives　Vol. 8　No. 2　2020/04　Research paper (scientific journal)

近位尿細管の上皮間葉転換においてインテグリンリガンドが果たす役割の解明

井阪 亮, 東阪 和馬, 石田 菜南, 坂橋 優治, 山口 慎太郎, 北原 剛, 藤尾 慈, 神出 計, 辻野 博文, 長野 一也, 堤 康央

日本薬学会年会要旨集　Vol. 140年会　p. 26F-pm11S　2020/03

心臓移植患者におけるミコフェノール酸モフェチルとプロトンポンプ阻害薬の併用安全性に関する検討

前田 真一郎, 栗原 由美子, 廣部 祥子, 前田 真貴子, 藤尾 慈

日本薬学会年会要旨集　Vol. 140年会　p. 26M-am11　2020/03

成人心臓移植患者のタクロリムス血中濃度データを用いた母集団薬物動態解析

近藤 研太朗, 吉田 茉莉, 廣部 祥子, 前田 真貴子, 藤尾 慈, 前田 真一郎

日本薬学会年会要旨集　Vol. 140年会　p. 27Z-am03S　2020/03

リツキシマブによる中等度以上のInfusion Reactionの発現予測に関する検討

深田 耕司, 宮本 真由, 犬飼 萌乃, 前田 真一郎, 前田 真貴子, 藤尾 慈, 廣部 祥子

日本薬学会年会要旨集　Vol. 140年会　p. 27Q-am163S　2020/03

Inhibition of transcription factor OASIS attenuated kidney fibrosis

Yamamoto Ayaha, Obana Masanori, Nakae Takafumi, Miyake Yoshiaki, Mitsuoka Sayuri, Maeda Makiko, Imaizumi Kazunori, Matsumoto Kotaro, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Development of a screening system for the compounds that induce the cell cycle activity in mammalian cardiomyocytes

Matsui Risa, Fukuyama Shoki, Kametani Yusuke, Wada Yuriko, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Dad1 inhibits cardiomyocyte death by promoting cell adhesion

Shota Mori, Kimura Rumi, Fuchigami Shota, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

β2 adrenergic signaling of cardiac fibroblasts induces cardiac hypertrophy through paracrine system

Imaeda Atsuki, Tanaka Shota, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

β2-adrenergic stimulation induces Arid5a through cAMP/PKA/CREB axis to promote IL-6 upregulation

Tanaka Shota, Imaeda Atsuki, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

Maresin 1, an anti-inflammatory lipid mediator, induces physiological hypertrophy in neonatal rat cardiomyocytes

Kobayashi Arisa, Tri Wahyuni, Igarashi Ryuta, Tomimatsu Masashi, Matsumoto Kotaro, Maeda Makiko, Obana Masanori, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 93　2020

[Preface].

Yasushi Fujio, Jong-Kook Lee

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 155　No. 5　p. 299-299　2020　Research paper (scientific journal)

The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.

Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI

Cell reports　Vol. 29　No. 8　p. 2154-2163.e5　2019/11　Research paper (scientific journal)

Verification of pharmacogenomics-based algorithms to predict warfarin maintenance dose using registered data of Japanese patients.

Sasano M, Ohno M, Fukuda Y, Nonen S, Hirobe S, Maeda S, Miwa Y, Yokoyama J, Nakayama H, Miyagawa S, Sawa Y, Fujio Y, Maeda M

European journal of clinical pharmacology　Vol. 75　No. 7　p. 901-911　2019/07　Research paper (scientific journal)

心不全病態における細胞骨格系蛋白質の発現変動とその機能解明

豊田 麻人, 東阪 和馬, 大須賀 絵理, 笠原 淳平, 櫻井 美由紀, 辻野 博文, 長野 一也, 藤尾 慈, 坂田 泰史, 堤 康央

日本薬学会年会要旨集　Vol. 139年会　No. 4　p. 174-174　2019/03

細胞接着関連蛋白質による近位尿細管の上皮間葉転換の抑制

井阪 亮, 東阪 和馬, 竹谷 苑子, 石田 菜南, 坂橋 優治, 山口 慎太郎, 藤尾 慈, 神出 計, 辻野 博文, 長野 一也, 堤 康央

日本薬学会年会要旨集　Vol. 139年会　No. 4　p. 63-63　2019/03

糖尿病性腎症における免疫関連蛋白質の分泌機序の解明に向けた基礎情報の収集

石田 菜南, 東阪 和馬, 竹谷 苑子, 井阪 亮, 坂橋 優治, 山口 慎太郎, 辻野 博文, 長野 一也, 藤尾 慈, 神出 計, 堤 康央

日本薬学会年会要旨集　Vol. 139年会　No. 4　p. 174-174　2019/03

エルロチニブ耐性化機構におけるPGRMC1の機能解析

林 穎, 東阪 和馬, 新谷 拓也, 花室 紗知代, 泉沢 航平, 芳賀 優弥, 前田 真一郎, 辻野 博文, 長野 一也, 藤尾 慈, 堤 康央

日本薬学会年会要旨集　Vol. 139年会　No. 4　p. 51-51　2019/03

Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice.

Imaeda A, Tanaka S, Tonegawa K, Fuchigami S, Obana M, Maeda M, Kihara M, Kiyonari H, Conway SJ, Fujio Y, Nakayama H

Biochemical and biophysical research communications　Vol. 510　No. 1　p. 149-155　2019/02　Research paper (scientific journal)

Inhibition of OASIS in podocytes suppressed diabetes-induced kidney dysfunction

Miyake Yoshiaki, Obana Masanori, Yamamoto Ayaha, Noda Shunsuke, Kanemoto Soshi, Maeda Makiko, Asanuma Katsuhiko, Imaizumi Kazunori, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Characterization of mononuclear cardiomyocytes in adult murine hearts

Nakayasu Yusuke, Matsui Risa, Fukuyama Shoki, Kametani Yusuke, Wada Yuriko, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Suppression of Defender against cell death 1 leads to cardiomyocyte death

Fuchigami Shota, Kimura Rumi, Matumoto Kotaro, Morihara Hirofumi, Mori Shota, Obana Masonori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

Comprehensive search for cardiomyocyte death-related genes using forward genetic screening

Nakayama Nami, Seo Takafumi, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

The overexpression of CGRRF1 induces hypertrophy in cultured cardiomyocytes

Kinoshita Maki, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　2019

ドラッグリポジショニングによる心筋保護サイトカイン治療開発の試み

前田 真貴子, 藤尾 慈

ファルマシア　Vol. 55　No. 3　p. 218-222　2019

Runx2-expressing myeloid cells ameliorate post-infarct cardiac remodeling as a novel cardioprotective subset

Matsumoto Kotaro, Ashizuka Moe, Kumagai Shohei, Okuzaki Daisuke, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

Proceedings for Annual Meeting of The Japanese Pharmacological Society　Vol. 92　p. 2-YIA-10　2019

Old-Age Onset Progressive Cardiac Contractile Dysfunction in a Patient with Polycystic Kidney Disease Harboring a PKD1 Frameshift Mutation.

Suwa Y, Higo S, Nakamoto K, Sera F, Kunimatsu S, Masumura Y, Kanzaki M, Mizote I, Mizuno H, Fujio Y, Hikoso S, Sakata Y

International heart journal　Vol. 60　No. 1　p. 220-225　2019/01　Research paper (scientific journal)

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation.

Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y

Journal of cell science　Vol. 132　No. 1　2019/01　Research paper (scientific journal)

Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.

Takuya Shintani, Kazuma Higashisaka, Makiko Maeda, Masaya Hamada, Ryosuke Tsuji, Koudai Kurihara, Yuri Kashiwagi, Atsuhiro Sato, Masanori Obana, Ayaha Yamamoto, Keisuke Kawasaki, Ying Lin, Takashi Kijima, Yuhei Kinehara, Yoshihiro Miwa, Shinichiro Maeda, Eiichi Morii, Atsushi Kumanogoh, Yasuo Tsutsumi, Izumi Nagatomo, Yasushi Fujio

Oncotarget　Vol. 9　No. 101　p. 37520-37533　2018/12/25　Research paper (scientific journal)

Blockade of NKG2D/NKG2D Ligand Interaction Attenuated Cardiac Remodeling after Myocardial Infarction.

Matsumoto K, Obana M, Kobayashi A, Kihara M, Shioi G, Miyagawa S, Maeda M, Sakata Y, Nakayama H, Sawa Y, Fujio Y

Cardiovascular research　Vol. 115　No. 4　p. 765-775　2018/10　Research paper (scientific journal)

慢性腎臓病に対する診断バイオマーカーの確立に向けた腎分泌蛋白質の有用性評価

石田 菜南, 東阪 和馬, 竹谷 苑子, 井阪 亮, 尾花 理徳, 鎌田 春彦, 前田 真貴子, 長野 一也, 藤尾 慈, 神出 計, 堤 康央

日本薬学会年会要旨集　Vol. 138年会　No. 4　p. 188-188　2018/03

近位尿細管細胞の上皮間葉転換に対する細胞接着関連蛋白質の寄与解明に向けた検討

井阪 亮, 東阪 和馬, 竹谷 苑子, 石田 奈南, 藤尾 慈, 神出 計, 長野 一也, 堤 康央

日本薬学会年会要旨集　Vol. 138年会　No. 3　p. 63-63　2018/03

Low-dose erythropoietin in patients with ST-segment elevation myocardial infarction (EPO-AMI-II): ― A randomized controlled clinical trial ―

Tetsuo Minamino, Shuichiro Higo, Ryo Araki, Shungo Hikoso, Daisaku Nakatani, Hiroshi Suzuki, Takahisa Yamada, Masaaki Okutsu, Kouji Yamamoto, Yasushi Fujio, Yoshio Ishida, Takuya Ozawa, Kiminori Kato, Ken Toba, Yoshifusa Aizawa, Issei Komuro, T. Toba, T. Ishimitsu, S. Higo, Y. Yasumura, T. Yamada, Y. Ueda, M. Nishino, H. Ito, H. Suzuki, A. Namiki, T. Tobaru, K. Ando, S. Yasuda, Y. Doi, S. Koba, M. Yasutake, Y. Akashi, S. Saito, M. Okutsu, Y. Kijima, T. Yoshida, N. Sato, Y. Sakai, Y. Ohira, EPO-AMI-II Investigators

Circulation Journal　Vol. 82　No. 4　p. 1083-1091　2018　Research paper (scientific journal)

The cardioprotective effect of interleukin-11 against ischemia-reperfusion injury in a heart donor model

Yusaku Tamura, Hiroki Kohno, Tomomi Mohri, Yasushi Fujio, Goro Matsumiya

Annals of Cardiothoracic Surgery　Vol. 7　No. 1　p. 99-105　2018/01/01　Research paper (scientific journal)

Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy.

Tanaka S, Fujio Y, Nakayama H

Frontiers in physiology　Vol. 9　p. 1081-1081　2018　Research paper (scientific journal)

Sustained Activation of Guanylate Cyclase-A with TDT, a Natriuretic Peptide Derivative, Exhibits Cardiorenal Protection in Dahl Salt-Sensitive Hypertensive Rats

Shohei Oishi, Naoko Suzuki, Yuri Hasui, Tsuyoshi Homma, Masanori Obana, Takahiro Nagayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS　Vol. 363　No. 3　p. 402-410　2017/12　Research paper (scientific journal)

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

Hirofumi Morihara, Masanori Obana, Shota Tanaka, Ikki Kawakatsu, Daisuke Tsuchiyama, Shota Mori, Hiroshi Suizu, Akiko Ishida, Rumi Kimura, Izuru Tsuchimochi, Makiko Maeda, Takehiko Yoshimitsu, Yasushi Fujio, Hiroyuki Nakayama

PLoS ONE　Vol. 12　No. 12　2017/12/01　Research paper (scientific journal)

Myofibroblast-Specific Deletion of Runx2 Improves Systolic Function and Survival in Late Phase of Cardiac Remodeling After Myocardial Infarction

Tanaka Shota, Enomoto Daichi, Yanase Emiko, Kumagai Shohei, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

CIRCULATION　Vol. 136　2017/11/14

Safety and Feasibility Report of Investigational Therapy With Interleukin-11 Against Acute Myocardial Infarction

Maeda Makiko, Nakagawa Masaki, Owada Yasuko, Izumi Yasukatsu, Nonin Shinichi, Sugioka Kenichi, Nakatani Daisaku, Iwata Shinichi, Mizutani Kazuki, Nishimura Satoshi, Ito Asahiro, Fujita Suwako, Daimon Takashi, Sawa Yoshiki, Asakura Masanori, Fujio Yasushi, Yoshiyama Minoru

CIRCULATION　Vol. 136　2017/11/14

ROR gamma t-expressing cells attenuate cardiac remodeling after myocardial infarction

Daichi Enomoto, Kotaro Matsumoto, Tomomi Yamashita, Arisa Kobayashi, Makiko Maeda, Hiroyuki Nakayama, Masanori Obana, Yasushi Fujio

PLOS ONE　Vol. 12　No. 8　2017/08　Research paper (scientific journal)

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice

Hirofumi Morihara, Tsuyoshi Yamamoto, Harunori Oiwa, Kota Tonegawa, Daisuke Tsuchiyama, Ikki Kawakatsu, Masanori Obana, Makiko Maeda, Tomomi Mohri, Satoshi Obika, Yasushi Fujio, Hiroyuki Nakayama

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS　Vol. 22　No. 3　p. 273-282　2017/05　Research paper (scientific journal)

Mouse model of Epstein-Barr virus LMP1-and LMP2A-driven germinal center B-cell lymphoproliferative disease

Takeharu Minamitani, Yijie Ma, Hufeng Zhou, Hiroshi Kida, Chao-Yuan Tsai, Masanori Obana, Daisuke Okuzaki, Yasushi Fujio, Atsushi Kumanogoh, Bo Zhao, Hitoshi Kikutani, Elliott Kieff, Benjamin E. Gewurz, Teruhito Yasui

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 114　No. 18　p. 4751-4756　2017/05　Research paper (scientific journal)

Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis

Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-ichiro Fukada, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/05　Research paper (scientific journal)

Fibroblast-specific PKA activation induces cardiac hypertrophy

Takahashi Misato, Tonegawa Kota, Fuchigami Shota, Tanaka Shota, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Elucidation of underlying mechanism of dynasore against ROS-induced CM death

Kawakatsu Ikki, Morihara Hirofumi, Kimura Rumi, Kubo Mikiko, Tsuchiyama Daisuke, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

ROR gamma t heterozygous deficiency aggravates cardiac remodeling after myocardial infarction

Enomoto Daichi, Obana Masanori, Matsumoto Kotaro, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

The deletion of Runx2 in fibroblasts has a protective role after MI

Yanase Emiko, Tanaka Shouta, Kumagai Shouhei, Enomoto Daichi, Nakayama Nami, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates tissue restoration with protrusion formation

Mitsuhara Yusuke, Miyawaki Akimitsu, Orimoto Aya, Nakayasu Yusuke, Tsunoda Shin-ichi, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Yoshioka Yasuo, Tsutsumi Yasuo, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

eIF4B is a cytoprotective molecule downstream of Pim-1 kinase in cardiomyocytes

Yokoyama Yukari, Matsumoto Kotaro, Kinoshita Maki, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Interleukin-11 therapy for cardioprotection against acute myocardial infarction

Fujio Yasushi, Maeda Makiko, Daimon Takashi, Nakatani Daisaku, Sugioka Kinichi, Iwata Shinichi, Sawa Yoshiki, Asakura Masanori, Izumi Yasukatsu, Yoshiyama Minoru

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 133　No. 3　2017/03

Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in alpha(1)-adrenergic stimulation

Kota Tonegawa, Wataru Otsuka, Shohei Kumagai, Sachi Matsunami, Nao Hayamizu, Shota Tanaka, Kazumasa Moriwaki, Masanori Obana, Makiko Maeda, Michio Asahi, Hiroshi Kiyonari, Yasushi Fujio, Hiroyuki Nakayama

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 312　No. 3　p. H501-H514　2017/03　Research paper (scientific journal)

Myeloid Cell-Specific Runx2 Deficiency Exacerbates Adverse Cardiac Remodeling After Myocardial Infarction

Moe Ashizuka, Shouhei Kumagai, Emiko Yanase, Masanori Obana, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION　Vol. 134　2016/11

Heterozygous Ablation of ROR gamma t Gene Deteriorates Adverse Cardiac Remodeling After Myocardial Infarction

Daichi Enomoto, Masanori Obana, Kotaro Matsumoto, Yasushi Sakata, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION　Vol. 134　2016/11

Adult Mammalian Hearts Restore Intrinsic Regenerative Capacity Through Signal Transducer and Activation of Transcription 3 in the Resolution Phase of Myocarditis

Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-ichiro Fukada, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio

CIRCULATION　Vol. 134　2016/11

Four cases of investigational therapy with interleukin-11 against acute myocardial infarction.

Masashi Nakagawa, Yasuko Owada, Yasukatsu Izumi, Shinichi Nonin, Kenichi Sugioka, Daisaku Nakatani, Shinichi Iwata, Kazuki Mizutani, Satoshi Nishimura, Asahiro Ito, Suwako Fujita, Takashi Daimon, Yoshiki Sawa, Masanori Asakura, Makiko Maeda, Yasushi Fujio, Minoru Yoshiyama

Heart and vessels　Vol. 31　No. 9　p. 1574-8　2016/09　Research paper (scientific journal)

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation

Akimitsu Miyawaki, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Shin-ichi Tsunoda, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasuo Yoshioka, Yasuo Tsutsumi, Yasushi Fujio

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 311　No. 2　p. H476-H486　2016/08　Research paper (scientific journal)

Elucidation of underlying mechanism of 2-APB against ROS-induced CM death

Ishida Akiko, Morihara Hirofumi, Kawakatsu Ikki, Tsuchiyama Daisuke, Kubo Mikiko, Obana Masanori, Maeda Makiko, Fujio Yasushi, Nakayama Hiroyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 130　No. 3　2016/03

Adult cardiomyocytes restore intrinsic regenerative capacity through STAT3 activation in the inflamed murine heart

Miyawaki Akimitsu, Takaya Tamaki, Mitsuhara Yusuke, Yamashita Tomomi, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 130　No. 3　2016/03

Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction

Shohei Kumagai, Hiroyuki Nakayama, Minoru Fujimoto, Hiromi Honda, Satoshi Serada, Hatsue Ishibashi-Ueda, Atsushi Kasai, Masanori Obana, Yasushi Sakata, Yoshiki Sawa, Yasushi Fujio, Tetsuji Naka

CARDIOVASCULAR RESEARCH　Vol. 109　No. 2　p. 272-282　2016/02　Research paper (scientific journal)

Adrenergic Receptors beta 2 and beta 3 Transduce Differential Signals in Cardiac Fibroblasts

Kota Tonegawa, Hiroyuki Nakayama, Hiromi Igarashi, Sachi Matsunami, Nao Hayamizu, Masanori Obana, Makiko Maeda, Yasushi Fujio

CIRCULATION　Vol. 132　2015/11

Blockade of NKG2D/NKG2D Ligands Interaction Attenuated Cardiac Remodeling After Myocardial Infarction

Kotaro Matsumoto, Masanori Obana, Rina Hashizume, Yukari Yokoyama, Shigeru Miyagawa, Tomomi Mohri, Makiko Maeda, Hiroyuki Nakayama, Yoshiki Sawa, Yasushi Fujio

CIRCULATION　Vol. 132　2015/11

Interleukin-27 induces the endothelial differentiation in Sca-1+cardiac resident stem cells

Tomohiro Tanaka, Masanori Obana, Tomomi Mohri, Masaki Ebara, Yuta Otani, Makiko Maeda, Yasushi Fujio

CYTOKINE　Vol. 75　No. 2　p. 365-372　2015/10　Research paper (scientific journal)

Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling

Daichi Enomoto, Masanori Obana, Akimitsu Miyawaki, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 309　No. 3　p. H471-H480　2015/08　Research paper (scientific journal)

Elucidation of molecular mechanism of cardiomyocyte necrosis induced by reactive oxygen species

Tsuchiyama Daisuke, Nakayama Hiroyuki, Morihara Hirofumi, Ishida Akiko, Obana Masanori, Maeda Makiko, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

Interleukin 27 induces endothelial differentiation in murine cardiac stem cells

Tanaka Tomohiro, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

IL-27 negatively regulates murine experimental autoimmune myocarditis (EAM)

Furutani Chika, Miyawaki Akimitsu, Otani Yuta, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

The properties of cardiac Sca-1+resident stem cells are altered in response to myocardial inflammation

Matsuhara Yumi, Miyawaki Akimitsu, Ebara Masaki, Obana Masanori, Maeda Makiko, Nakayama Hiroyuki, Fujio Yasushi

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　2015/07

Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy.

Kobayashi M, Takemoto Y, Norioka N, Iguchi T, Shimada K, Maeda M, Morimura M, Fujio Y, Azuma J, Yoshiyama M, Hirohashi K, Shuto T

Osaka city medical journal　Vol. 61　No. 1　p. 19-30　2015/06

The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes

Reo Matsuo, Hirofumi Morihara, Tomomi Mohri, Shiho Murasawa, Kana Takewaki, Hiroyuki Nakayama, Makiko Maeda, Yasushi Fujio

PLOS ONE　Vol. 9　No. 10　2014/10　Research paper (scientific journal)

A novel cytokine therapy for cardiovascular disease

Yasuko Owada, Makiko Maeda, Yasushi Fujio

Japanese Journal of Clinical Chemistry　Vol. 43　No. 3　p. 191-196　2014　Research paper (scientific journal)

Proteomics approach for searching diagnostic markers of Parkinson's disease.

MISATO Kazuki, MUKAI Yohei, HIGASHISAKA Kazuma, YOSHIOKA Yasuo, NAGANO Kazuya, KAMADA Haruhiko, FUJIO Yasushi, MOCHIZUKI Hideki, TSUNODA Shin-ichi, TSUTSUMI Yasuo

Abstracts for Annual Meeting of Japanese Proteomics Society　Vol. 2014　p. 73-73　2014

Requirement of SLD5 for Early Embryogenesis

Tomomi Mohri, Masaya Ueno, Yumi Nagahama, Zhi-Yuan Gong, Masahide Asano, Hiroko Oshima, Masanobu Oshima, Yasushi Fujio, Nobuyuki Takakura

PLOS ONE　Vol. 8　No. 11　2013/11　Research paper (scientific journal)

Polymorphisms of CYP2D6 Gene and Gefitinib-Induced Hepatotoxicity

Takayuki Takimoto, Takashi Kijima, Yasushi Otani, Shinpei Nonen, Yoshinobu Namba, Masahide Mori, Soichiro Yokota, Seigo Minami, Kiyoshi Komuta, Junji Uchida, Fumio Imamura, Mitsugi Furukawa, Naotoshi Tsuruta, Yasushi Fujio, Junichi Azuma, Isao Tachibana, Atsushi Kumanogoh

CLINICAL LUNG CANCER　Vol. 14　No. 5　p. 502-507　2013/09　Research paper (scientific journal)

Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling

Shohei Kumagai, Kazuki Matsui, Haruyo Kawaguchi, Tomomi Yamashita, Tomomi Mohri, Yasushi Fujio, Hiroyuki Nakayama

Biochemical and Biophysical Research Communications　Vol. 437　No. 4　p. 609-614　2013/08/09　Research paper (scientific journal)

Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy

Takeshi Yamada, Masashi Nakayama, Tomohito Shimizu, Shinpei Nonen, Yasutomo Nakai, Kazuo Nishimura, Yasushi Fujio, Akihiko Okuyama, Junichi Azuma, Norio Nonomura

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　Vol. 18　No. 4　p. 711-717　2013/08　Research paper (scientific journal)

NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy

Junichi Azuma, Masako Ohno, Ryuji Kubota, Soichiro Yokota, Takayuki Nagai, Kazunari Tsuyuguchi, Yasuhisa Okuda, Tetsuya Takashima, Sayaka Kamimura, Yasushi Fujio, Ichiro Kawase

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY　Vol. 69　No. 5　p. 1091-1101　2013/05　Research paper (scientific journal)

Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study

Hiroshi Okamoto, Masatsugu Hori, Masunori Matsuzaki, Hiroyuki Tsutsui, Tsutomu Yamazaki, Ryozo Nagai, Tsutomu Yoshikawa, Yasushi Fujio, Shinpei Nonen, Junichi Azuma, Tohru Izumi, Yasuo Ohashi, Akira Kitabatake

INTERNATIONAL JOURNAL OF CARDIOLOGY　Vol. 164　No. 2　p. 238-244　2013/04　Research paper (scientific journal)

Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart

Masanori Obana, Kaori Miyamoto, Shiho Murasawa, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Momoko Shiragaki, Shohei Kumagai, Akimitsu Miyawaki, Kana Takewaki, Goro Matsumiya, Makiko Maeda, Minoru Yoshiyama, Hiroyuki Nakayama, Yasushi Fujio

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 303　No. 5　p. H569-H577　2012/09　Research paper (scientific journal)

Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation and Atherosclerosis in Apolipoprotein E Knockout Mice

Kaori Higuchi, Yoshikazu Nakaoka, Wataru Shioyama, Yoh Arita, Takahiro Hashimoto, Taku Yasui, Kuniyasu Ikeoka, Tadashi Kuroda, Takashi Minami, Keigo Nishida, Yasushi Fujio, Keiko Yamauchi-Takihara, Mikiyasu Shirai, Naoki Mochizuki, Issei Komuro

CIRCULATION JOURNAL　Vol. 76　No. 8　p. 2031-2040　2012/08　Research paper (scientific journal)

Interleukin-11 Exhibits the Post-conditioning Effects against Ischemia Reperfusion injury via Cardiac Signal Transducer and Activator of Transcription 3

Kaori Miyamoto, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 118　p. 86P-86P　2012

Interleukin-11 Attenuates Infarct Size And Improves Ventricular Function In a Canine Heart Model Of Ischemia/Reperfusion Injury

Makiko Maeda, Koji Takeda, Goro Matsumiya, Junichi Azuma, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 118　p. 244P-244P　2012

Glycoprotein 130 Cytokine Signal as a Therapeutic Target Against Cardiovascular Diseases

Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Hiroyuki Nakayama, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 117　No. 4　p. 213-222　2011/12

[Genetic analysis for nicotine dependence].

Maeda M, Fujio Y, Azuma J

Nihon rinsho. Japanese journal of clinical medicine　Vol. 69　No. 10　p. 1887-1890　2011/10　Research paper (scientific journal)

Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population

Hiroyuki Nakayama, Hiromi Nagai, Kyotaka Matsumoto, Ryosuke Oguro, Ken Sugimoto, Kei Kamide, Mitsuru Ohishi, Tomohiro Katsuya, Hiroshi Okamoto, Makiko Maeda, Kazuo Komamura, Junichi Azuma, Hiromi Rakugi, Yasushi Fujio

HYPERTENSION RESEARCH　Vol. 34　No. 10　p. 1141-1146　2011/10　Research paper (scientific journal)

IL-6-mediated Th17 differentiation through ROR gamma t is essential for the initiation of experimental autoimmune myocarditis

Tomomi Yamashita, Tomohiko Iwakura, Kazuki Matsui, Haruyo Kawaguchi, Masanori Obana, Akiko Hayama, Makiko Maeda, Yasukatsu Izumi, Issei Komuro, Yoshiyuki Ohsugi, Minoru Fujimoto, Tetsuji Naka, Tadamitsu Kishimoto, Hiroyuki Nakayama, Yasushi Fujio

CARDIOVASCULAR RESEARCH　Vol. 91　No. 4　p. 640-648　2011/09　Research paper (scientific journal)

STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+cells both in vitro and in vivo

Tomohiko Iwakura, Tomomi Mohri, Tatsuto Hamatani, Masanori Obana, Tomomi Yamashita, Makiko Maeda, Naoto Katakami, Hideaki Kaneto, Toru Oka, Issei Komuro, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 51　No. 2　p. 207-214　2011/08　Research paper (scientific journal)

Safe and Successful Treatment With Erlotinib After Gefitinib-Induced Hepatotoxicity: Difference in Metabolism As a Possible Mechanism

Takashi Kijima, Tomohito Shimizu, Shinpei Nonen, Mitsugi Furukawa, Yasushi Otani, Toshiyuki Minami, Ryo Takahashi, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida, Sho Goya, Yasushi Fujio, Junichi Azuma, Isao Tachibana, Ichiro Kawase

JOURNAL OF CLINICAL ONCOLOGY　Vol. 29　No. 19　p. E588-E590　2011/07　Research paper (scientific journal)

S9-6. Toward PGx-Guided "Personalized Medicine" : Multicenter Randomized Pharmacogenomic Trial for Tuberculosis Therapy

OHNO Masako, KUBOTA Ryuji, KAMIMURA Sayaka, YOKOTA Soichiro, MAEKURA Ryoji, NAGAI Takayuki, TAKASHIMA Tetsuya, TSUYUGUCHI Kazunari, OKUDA Yasuhisa, ITO Tsugutaka, FUJIO Yasushi, AZUMA Junichi

Jpn. J. Clin. Pharmacol. Ther.　Vol. 42　No. 3　p. 153-153　2011/05/31

Docking Protein Gab1 Is an Essential Component of Postnatal Angiogenesis After Ischemia via HGF/c-Met Signaling

Wataru Shioyama, Yoshikazu Nakaoka, Kaori Higuchi, Takashi Minami, Yoshiaki Taniyama, Keigo Nishida, Hiroyasu Kidoya, Takashi Sonobe, Hisamichi Naito, Yoh Arita, Takahiro Hashimoto, Tadashi Kuroda, Yasushi Fujio, Mikiyasu Shirai, Nobuyuki Takakura, Ryuichi Morishita, Keiko Yamauchi-Takihara, Tatsuhiko Kodama, Toshio Hirano, Naoki Mochizuki, Issei Komuro

CIRCULATION RESEARCH　Vol. 108　No. 6　p. 664-U299　2011/03　Research paper (scientific journal)

Interleukin-11 exhibits the post-conditioning effects against ischemia reperfusion injury through cardiac STAT3 activation

Masanori Obana, Kaori Miyamoto, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Shiho Murasawa, Momoko Shiragaki, Makiko Maeda, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 115　p. 110P-110P　2011

Interleukin-6 family cytokines induce endothelial cell differentiation of cardiac Sca-1+cells via STAT3/Pim-1 signaling pathway

Tomohiko Iwakura, Tomomi Mohri, Tatsuto Hamatani, Tomomi Yamashita, Masanori Obana, Akiko Hayama, Kazuki Matsui, Makiko Maeda, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 115　p. 96P-96P　2011

Cathelicidin antimicrobial peptide (CAMP) is induced in autoimmune myocarditis and reduces the motility of cardiac fibroblasts

Kazuki Matsui, Tomomi Yamashita, Haruyo Kawaguchi, Tomohiko Iwakura, Masanori Obana, Akiko Hayama, Shiho Murasawa, Kohei Katayama, Momoko Shiragaki, Makiko Maeda, Junichi Azuma, Hiroyuki Nakayama, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 115　p. 110P-110P　2011

Cigarette Smoke Extract Induces CYP2B6 through Constitutive Androstane Receptor in Hepatocytes

Ikumi Washio, Makiko Maeda, Chika Sugiura, Ryota Shiga, Mitsuhiro Yoshida, Shinpei Nonen, Yasushi Fujio, Junichi Azuma

DRUG METABOLISM AND DISPOSITION　Vol. 39　No. 1　p. 1-3　2011/01　Research paper (scientific journal)

RGS2 determines the preventive effects of ARBs against vascular remodeling: toward personalized medicine of anti-hypertensive therapy with ARBs

Yasushi Fujio

HYPERTENSION RESEARCH　Vol. 33　No. 12　p. 1221-1222　2010/12

Pim-1 Kinase is Required for Endothelial Differentiation of Cardiac Stem Cells via STAT3 Signaling Pathway

Tomohiko Iwakura, Tomomi Mohri, Tatsuto Hamatani, Tomomi Yamashita, Masanori Obana, Akiko Hayama, Makiko Maeda, Hiroyuki Nakayama, Issei Komuro, Junichi Azuma, Yasushi Fujio

CIRCULATION　Vol. 122　No. 21　2010/11

The Gene Polymorphisms of CYP2A6 and the Nicotinic Acetylcholine Receptor alpha 4 Subunit Influence Nicotine Dependence, Which is One of the Cardiovascular Risk Factors, in Japanese Smokers

Makiko Maeda, Chieko N. Taniguchi, Masanobu Funamoto, Genta Miura, Tomoko Kubota, Chika Sugiura, Ryota Shiga, Shipei Nonen, Yasushi Fujio, Junichi Azuma

CIRCULATION　Vol. 122　No. 21　2010/11

SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene

Yoshikazu Nakaoka, Wataru Shioyama, Satoshi Kunimoto, Yoh Arita, Kaori Higuchi, Kaori Yamamoto, Yasushi Fujio, Keigo Nishida, Tadashi Kuroda, Hisao Hirota, Keiko Yamauchi-Takihara, Toshio Hirano, Issei Komuro, Naoki Mochizuki

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 49　No. 2　p. 157-164　2010/08　Research paper (scientific journal)

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

Masanori Obana, Makiko Maeda, Koji Takeda, Akiko Hayama, Tomomi Mohri, Tomomi Yamashita, Yoshikazu Nakaoka, Issei Komuro, Kiyoshi Takeda, Goro Matsumiya, Junichi Azuma, Yasushi Fujio

CIRCULATION　Vol. 121　No. 5　p. 684-U121　2010/02　Research paper (scientific journal)

Interleukin-11 ameliorates cardiac remodeling after myocardial infarction through STAT3

Masanori Obana, Makiko Maeda, Junichi Azuma, Yasushi Fujio

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 112　p. 74P-74P　2010

Interleukin-11 Attenuates Infarct Size and Improves Ventricular Function in a Canine Heart Model of Ischemia/Reperfusion Injury

Koji Takeda, Goro Matsumiya, Shigeru Miyagawa, Makiko Maeda, Yasushi Fujio, Yoshiki Sawa

CIRCULATION　Vol. 120　No. 18　p. S737-S737　2009/11

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients

Masako Ohno, Akiko Yamamoto, Ayumu Ono, Genta Miura, Masanobu Funamoto, Yasuhiko Takemoto, Kinya Otsu, Yasushi Kouno, Tomoko Tanabe, Yuiko Masunaga, Shinpei Nonen, Yasushi Fujio, Junichi Azuma

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY　Vol. 65　No. 11　p. 1097-1103　2009/11　Research paper (scientific journal)

Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension

Yoshimune Hiramoto, Wataru Shioyama, Kaori Higuchi, Yoh Arita, Tadashi Kuroda, Yasushi Sakata, Yoshikazu Nakaoka, Yasushi Fujio, Keiko Yamauchi-Takihara

JOURNAL OF CARDIOLOGY　Vol. 53　No. 3　p. 374-380　2009/06　Research paper (scientific journal)

Signals Through Glycoprotein 130 Regulate the Endothelial Differentiation of Cardiac Stem Cells

Tomomi Mohri, Yasushi Fujio, Masanori Obana, Tomohiko Iwakura, Koichi Matsuda, Makiko Maeda, Junichi Azuma

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 29　No. 5　p. 754-760　2009/05　Research paper (scientific journal)

Analyses on the in vivo transdifferentiation of cardiac stem cells into endothelial cell lineage in post-infarct myocardium

Koichi Matsuda, Yasushi Fujio, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Tomomi Yamashita, Akiko Hayama, Makiko Maeda, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 118P-118P　2009

Th17 cells are induced in chronic inflammation after myocardial infarction

Akiko Hayama, Yasushi Fujio, Masanori Obana, Tomomi Mohri, Tomomi Yamashita, Tomohiko Iwakura, Makiko Maeda, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 118P-118P　2009

IL-6 family cytokines induce IL-10 in cardiac myocytes via STAT3 and ERK1/2 signaling pathway

Tomohiko Iwakura, Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Koichi Matsuda, Tomomi Yamashita, Akiko Hayama, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 62P-62P　2009

The infiltration of Th17 cells into myocardium is associated with severity of the inflammation in experimental autoimmune myocarditis (EAM)

Tomomi Yamashita, Yasushi Fujio, Akiko Hayama, Kouichi Matsuda, Masanori Obana, Tomohiko Iwakura, Tornomi Mohri, Makiko Maeda, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 109　p. 117P-117P　2009

Involvement of Transcriptional Factor TonEBP in the Regulation of the Taurine Transporter in the Cardiomyocyte

Takashi Ito, Yasushi Fujio, Stephen W. Schaffer, Junichi Azuma

Taurine 7　Vol. 643　p. 523-532　2009　Research paper (scientific journal)

Beneficial Effect of Taurine Treatment Against Doxorubicin-Induced Cardiotoxicity in Mice

Takashi Ito, Satoko Muraoka, Kyoko Takahashi, Yasushi Fujio, Stephen W. Schaffer, Junichi Azuma

Taurine 7　Vol. 643　p. 65-74　2009　Research paper (scientific journal)

Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: Comparison with Korean, Chinese, and Caucasian populations

S. P. Myrand, K. Sekiguchi, M. Z. Man, X. Lin, R-Y Tzeng, C-H Teng, B. Hee, M. Garrett, H. Kikkawa, C-Y Lin, S. M. Eddy, J. Dostalik, J. Mount, J. Azuma, Y. Fujio, I-J Jang, S-G Shin, M. R. Bleavins, J. A. Williams, J. D. Paulauskis, K. D. Wilner

CLINICAL PHARMACOLOGY & THERAPEUTICS　Vol. 84　No. 3　p. 347-361　2008/09　Research paper (scientific journal)

Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway

Tatsuya Koyama, Yoshikazu Nakaoka, Yasushi Fujio, Hisao Hirota, Keigo Nishida, Shoko Sugiyama, Kitaro Okamoto, Keiko Yamauchi-Takihara, Michihiro Yoshimura, Seibu Mochizuki, Masatsugu Hori, Toshio Hiran, Naoki Mochizuki

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 283　No. 35　p. 24234-24244　2008/08　Research paper (scientific journal)

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes

Yasuhiro Yamamoto, Yuki Hoshino, Takashi Ito, Tetsuro Nariai, Tomomi Mohri, Masanori Obana, Nozomi Hayata, Yoriko Uozumi, Makiko Maeda, Yasushi Fujio, Junichi Azuma

CARDIOVASCULAR RESEARCH　Vol. 79　No. 1　p. 89-96　2008/07　Research paper (scientific journal)

Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy

Takashi Ito, Yasushi Kimura, Yoriko Uozumi, Mika Takai, Satoko Muraoka, Takahisa Matsuda, Kei Ueki, Minoru Yoshiyama, Masahito Ikawa, Masara Okabe, Stephen W. Schaffer, Yasushi Fujio, Junichi Azuma

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 44　No. 5　p. 927-937　2008/05　Research paper (scientific journal)

Connective tissue growth factor induces cardiac hypertrophy through Akt signaling

Nozomi Hayata, Yasushi Fujio, Yasuhiro Yamamoto, Tomohiko Iwakura, Masanori Obana, Mika Takai, Tomomi Mohri, Shinpei Nonen, Makiko Maeda, Junichi Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 370　No. 2　p. 274-278　2008/05　Research paper (scientific journal)

MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients

Makiko Maeda, Isamu Yamamoto, Masakatsu Fukuda, Takashi Motomura, Mari Nishida, Shinpei Nonen, Soji Kasayama, Yasushi Fujio, Junichi Azuma

JOURNAL OF DIABETES AND ITS COMPLICATIONS　Vol. 22　No. 2　p. 119-125　2008/03　Research paper (scientific journal)

Polymorphisms of norepinephrine transporter and adrenergic receptor alpha(1D) are associated with the response to beta-blockers in dilated cardiomyopathy

S. Nonen, H. Okamoto, Y. Fujio, Y. Takemoto, M. Yoshiyama, T. Hamaguchi, Y. Matsui, J. Yoshikawa, A. Kitabatake, J. Azuma

PHARMACOGENOMICS JOURNAL　Vol. 8　No. 1　p. 78-84　2008/02　Research paper (scientific journal)

Adrenergic beta(1) receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients

Shinpei Nonen, Isamu Yamamoto, Jianmin Liu, Makiko Maeda, Takashi Motomura, Tsuyoshi Igarashi, Yasushi Fujio, Junichi Azuma

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 31　No. 2　p. 295-298　2008/02　Research paper (scientific journal)

Signals through gp130 mediate the endothelial differentiation in cardiac Sca-1+stem cells

Tomomi Mohri, Yasushi Fujio, Tomohiko Iwakura, Masanori Obana, Koichi Matsuda, Makiko Maeda, Takashi Ito, Yasuhiro Yamamoto, Nozomi Hayata, Akiko Hayama, Tomomi Yamashita, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 58P-58P　2008

Skeletal muscle-derived Sca-1+stem cells are differentiated into endothelial cells by Leukemia inhibitory factor

Tomohiko Iwakura, Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Koichi Matsuda, Tomomi Yamashita, Takashi Ito, Yasuhiro Yamamoto, Masanori Obana, Nozomi Hayata, Mika Takai, Akiko Hayama, Yukako Ueno, Haruaki Nobori, Kouhei Yamashita, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 99P-99P　2008

Interleukin (IL)-11 ameliorates cardiac remodeling with angiogenic and anti-inflammatory effects in murine myocardial infarction model

Masanori Obana, Makiko Maeda, Yasubito Yamamoto, Takashi Ito, Tomomi Mohri, Tomohiko Iwakura, Nozomi Hayata, Mika Takai, Akiko Hayama, Koichi Matsuda, Kouhei Yamashita, Yasushi Fujio, Juriichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 112P-112P　2008

Connective tissue growth factor mediates hypertrophic signals through its C-terminal domain in cultured cardiac myocytes

Nozomi Hayata, Yasushi Fujio, Takashi Ito, Tomomi Mohri, Yasuhiro Yamamoto, Masanori Obana, Tomohiko Iwakura, Mika Takai, Koichi Matsuda, Yukako Ueno, Makiko Maeda, Shinpei Nonen, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 106　p. 120P-120P　2008

Interleukin-11 prevents cardiac remodeling after myocardial infarction with Neovascularization in murine model

Masanori Obana, Makiko Maeda, Yasuhiro Yamamoto, Takashi Ito, Tomomi Mohn, Tomohiko Iwakura, Nozomi Hayata, Mika Takai, Akiko Hayama, Koichi Matsuda, Kouhei Yamashita, Yasushi Fujio, Junichi Azuma

CIRCULATION　Vol. 116　No. 16　p. 262-262　2007/10

Signals through glycoprotein 130 promote the endothelial differentiation of cardiac Sca(-1)+ cells

Tomomi Mohri, Yasushi Fujio, Tomohiko Iwakura, Masanori Obana, Koichi Matsuda, Makiko Maeda, Takashi Ito, Yasuhiro Yamamoto, Nozomi Hayata, Junichi Azuma

CIRCULATION　Vol. 116　No. 16　p. 48-48　2007/10

Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes

Takashi Ito, Koko Asakura, Katsuhiko Tougou, Tsuyoshi Fukuda, Ryuji Kubota, Shinpei Nonen, Yasushi Fujio, Junichi Azuma

MOLECULAR PHARMACOLOGY　Vol. 72　No. 1　p. 173-181　2007/07　Research paper (scientific journal)

Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling

Yoshikazu Nakaoka, Keigo Nishida, Masahiro Narimatsu, Atsunori Kamiya, Takashi Minami, Hirofumi Sawa, Katsuya Okawa, Yasushi Fujio, Tatsuya Koyama, Makiko Maeda, Manami Sone, Satoru Yamasaki, Yuji Arai, Gou Young Koh, Tatsuhiko Kodama, Hisao Hirota, Kinya Otsu, Toshio Hirano, Naoki Mochizuki

JOURNAL OF CLINICAL INVESTIGATION　Vol. 117　No. 7　p. 1771-1781　2007/07　Research paper (scientific journal)

Carbacyclin induces carnitine palmitoyltransferase-1 in cardiornyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway

Tadashi Kuroda, Hisao Hirota, Yasushi Fujio, Shoko Suglyama, Mitsuru Masaki, Yoshimune Hiramoto, Wataru Shioyama, Kitaro Okamoto, Masatsugu Horl, Keiko Yamauchi-Takihara

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 43　No. 1　p. 54-62　2007/07　Research paper (scientific journal)

Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine

Ryusuke Kimura, Makiko Maeda, Atsushi Arita, Yuichi Oshima, Masanori Obana, Takashi Ito, Yasuhiro Yamamoto, Tomorm Mohri, Tadamitsu Kishimoto, Ichiro Kawase, Yasushi Fujio, Junichi Azuma

CYTOKINE　Vol. 38　No. 2　p. 107-115　2007/05　Research paper (scientific journal)

Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension

Yoshimune Hiramoto, Wataru Shioyama, Tadashi Kuroda, Mitsuru Masaki, Shoko Sugiyama, Kitaro Okamoto, Hisao Hirota, Yasushi Fujio, Masatsugu Hori, Keiko Yamauchi-Takihara

CIRCULATION JOURNAL　Vol. 71　No. 3　p. 367-369　2007/03　Research paper (scientific journal)

Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress

Masako Yamane, Takahisa Matsuda, Takashi Ito, Yasushi Fujio, Kyoko Takahashi, Junichi Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 353　No. 4　p. 1023-1027　2007/02　Research paper (scientific journal)

Interleukin (IL)-11 prevents ischemia/reperfusion (I/R) injury in hearts as a novel card ioprotective cytokine.

Makiko Maeda, Ryusuke Kimura, Atsushi Arita, Masanori Obana, Yasuhiro Yamamoto, Tomomi Mohri, Tomohiko Iwakura, Koichi Mastuda, Takashi Ito, Yasushi Kimura, Yuichi Oshima, Yasushi Fujio, Junichi Azuma

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 103　p. 117P-117P　2007

Genetic polymorphism of bile acid CoA: Amino acid n-alpha cyltransferase in Japanese individuals

Katsuhiko Tougou, Tsuyoshi Fukuda, Takashi Ito, Hiroshi Yamazaki, Yasushi Fujio, Junichi Azuma

DRUG METABOLISM AND PHARMACOKINETICS　Vol. 22　No. 2　p. 125-128　2007　Research paper (scientific journal)

Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes

Takashi Ito, Yasushi Fujio, Kyoko Takahashi, Junichi Azuma

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 282　No. 2　p. 1152-1160　2007/01　Research paper (scientific journal)

MTHFR gene polymorphism and diabetic retinopathy

Makiko Maeda, Yasushi Fujio, Junichi Azuma

Current Diabetes Reviews　Vol. 2　No. 4　p. 467-476　2006/11

Warfarin dose requirement for patients with both VKORCI 3673A/A and CYP2C9*3/*3 genotypes

Tsuyoshi Fukuda, Tomoko Tanabe, Masako Ohno, Katsuhiko Tougou, Yasushi Fujio, Junichi Azuma, Isamu Yamamoto, Akira Takeda

CLINICAL PHARMACOLOGY & THERAPEUTICS　Vol. 80　No. 5　p. 553-554　2006/11

Interleukin (IL)-11 prevents ischemia/reperfusion injury in hearts as a novel cardioprotective cytokine

Makiko Maeda, Yasushi Fujio, Ryusuke Kimura, Atsushi Arita, Takashi Itoh, Yasuhiro Yamamoto, Tomomi Mohri, Yuichi Oshima, Junich Azuma

CIRCULATION　Vol. 114　No. 18　p. 208-208　2006/10

Atrogin-1 ubiquitin ligase is upregulated by doxorubicin, leading to muscle atrophy in cardiac myocytes

Yasushi Fujio, Yuki Hoshino-Nariai, Yasuhiro Yamamoto, Takashi Ito, Yoriko Uozumi, Tomomi Mohri, Masanori Obana, Tetsurou Nariai, Yasushi Kimura, Makiko Maeda, Junichi Azuma

CIRCULATION　Vol. 114　No. 18　p. 332-332　2006/10

Cardiac sca-1+cells were differentiated into endothelial cells by leukemia inhibitory factor, a paracrine cytokine

Tomomi Mohh, Yasushi Fujio, Makiko Maeda, Takashi Ito, Tomohiko Iwakura, Yoriko Uozumi, Yasuhiro Yamamoto, Junichi Azuma

CIRCULATION　Vol. 114　No. 18　p. 120-120　2006/10

Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: Implication of tumor vascularization

Masayoshi Yasui, Hirofumi Yamamoto, Chew Yee Ngan, Bazarragchaa Damdinsuren, Yurika Sugita, Hiroki Fukunaga, Jinyu Gu, Makiko Maeda, Ichiro Takemasa, Masataka Ikeda, Yasushi Fujio, Mitsugu Sekimoto, Nariaki Matsuura, I. Bernard Weinstein, Morito Monden

CLINICAL CANCER RESEARCH　Vol. 12　No. 15　p. 4720-4729　2006/08　Research paper (scientific journal)

Degradation of transcription factor NFAT5 is induced by doxorubicin exposure in cultured cardiomyocytes

Ito Takashi, Uozumi Yoriko, Maeda Makiko, Yamamoto Yasuhiro, Mohri Tomomi, Fujio Yasushi, Azuma Junichi

ACTA PHARMACOLOGICA SINICA　Vol. 27　p. 140-140　2006/07

Leukemia inhibitory factor induces endothelial differentiation in cardiac Sca-1+stem cells

Mohri Tomomi, Fujio Yasushi, Maeda Makiko, Ito Takashi, Iwakura Tomo-hiko, Oshima Yuichi, Uozumi Yoriko, Yamamoto Yasuhiro, Azuma Junichi

ACTA PHARMACOLOGICA SINICA　Vol. 27　p. 183-183　2006/07

N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes

T Matsuda, Y Fujio, T Nariai, T Ito, M Yamane, T Takatani, K Takahashi, J Azuma

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 40　No. 4　p. 495-502　2006/04　Research paper (scientific journal)

Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles

Y Uozumi, T Ito, Y Hoshino, T Mohri, M Maeda, K Takahashi, Y Fujio, J Azuma

BIOCHEMICAL JOURNAL　Vol. 394　p. 699-706　2006/03　Research paper (scientific journal)

Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells

T Mohri, Y Fujio, M Maeda, T Ito, T Iwakura, Y Oshima, Y Uozumi, M Segawa, H Yamamoto, T Kishimoto, J Azuma

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 281　No. 10　p. 6442-6447　2006/03　Research paper (scientific journal)

CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation

T Kubota, C Nakajima-Taniguchi, T Fukuda, M Funamoto, M Maeda, E Tange, R Ueki, K Kawashima, H Hara, Y Fujio, J Azuma

PHARMACOGENOMICS JOURNAL　Vol. 6　No. 2　p. 115-119　2006/03　Research paper (scientific journal)

TauT gene expression is regulated by TonEBP and plays a role in cell survival

Takashi Ito, Yasushi Fujio, Yoriko Uozumi, Takahisa Matsuda, Makiko Maeda, Kyoko Takahashi, Junichi Azuma

TAURINE 6　Vol. 583　p. 91-98　2006　Research paper (scientific journal)

Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy

Yoriko Uozumi, Takashi Ito, Kyoko Takahashi, Takahisa Matsuda, Tomomi Mohri, Yasushi Kimura, Yasushi Fujio, Junichi Azuma

TAURINE 6　Vol. 583　p. 265-270　2006　Research paper (scientific journal)

Molecular mechanisms of cardioprotection by taurine on ischemia-induced apoptosis in cultured cardiomyocytes

Kyoko Takahashi, Tomoka Takatani, Yoriko Uozumi, Takashi Ito, Takahisa Matsuda, Yasushi Fujio, Stephen W. Schaffer, Junichi Azuma

TAURINE 6　Vol. 583　p. 257-263　2006　Research paper (scientific journal)

No positive association between adrenergic receptor variants of alpha(2c)Del322-325, beta(1)Ser49, beta(1)Arg389 and the risk for heart failure in the Japanese population

S Nonen, H Okamoto, M Akino, Y Matsui, Y Fujio, M Yoshiyama, Y Takemoto, J Yoshikawa, J Azuma, A Kitabatake

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY　Vol. 60　No. 4　p. 414-417　2005/10　Research paper (scientific journal)

Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines - Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells

Q Lin, R Lai, LR Chirieac, CP Li, VA Thomazy, L Grammatikakis, GZ Rassidakis, W Zhang, Y Fujio, K Kunisada, Hamilton, SR, HM Amin

AMERICAN JOURNAL OF PATHOLOGY　Vol. 167　No. 4　p. 969-980　2005/10　Research paper (scientific journal)

Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages

C Sumita, M Yamane, T Matsuda, M Maeda, T Nariai, Y Fujio, J Azuma

FEBS LETTERS　Vol. 579　No. 18　p. 4038-4042　2005/07　Research paper (scientific journal)

STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart

Y Oshima, Y Fujio, T Nakanishi, N Itoh, Y Yamamoto, S Negoro, K Tanaka, T Kishimoto, Kawase, I, J Azuma

CARDIOVASCULAR RESEARCH　Vol. 65　No. 2　p. 428-435　2005/02　Research paper (scientific journal)

N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes

T Matsuda, K Takahashi, T Nariai, T Ito, T Takatani, Y Fujio, J Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 326　No. 1　p. 228-232　2005/01　Research paper (scientific journal)

Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome

T Takatani, K Takahashi, Y Uozumi, E Shikata, Y Yamamoto, T Ito, T Matsuda, SW Schaffer, Y Fujio, J Azuma

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY　Vol. 287　No. 4　p. C949-C953　2004/10　Research paper (scientific journal)

Leptin stimulates ischemia-induced retinal neovascularization - Possible role of vascular endothelial growth factor expressed in retinal endothelial cells

E Suganami, H Takagi, H Ohashi, K Suzuma, Suzuma, I, H Oh, D Watanabe, T Ojima, T Suganami, Y Fujio, K Nakao, Y Ogawa, N Yoshimura

DIABETES　Vol. 53　No. 9　p. 2443-2448　2004/09　Research paper (scientific journal)

Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure

H Hirota, M Izumi, T Hamaguchi, S Sugiyama, E Murakami, K Kunisada, Y Fujio, Y Oshima, Y Nakaoka, K Yamauchi-Takihara

HEART AND VESSELS　Vol. 19　No. 5　p. 237-241　2004/09　Research paper (scientific journal)

Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.

Chinuyo Sumita, Makiko Maeda, Yasushi Fujio, Jooyeon Kim, Junko Fujitsu, Soji Kasayama, Isamu Yamamoto, Junichi Azuma

Biochimica et biophysica acta　Vol. 1673　No. 3　p. 115-21　2004/08/04　Research paper (scientific journal)

Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes

Y Fujio, T Matsuda, Y Oshima, M Maeda, T Mohri, T Ito, T Takatani, M Hirata, Y Nakaoka, R Kimura, T Kishimoto, J Azuma

FEBS LETTERS　Vol. 573　No. 1-3　p. 202-206　2004/08　Research paper (scientific journal)

Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage

C Sumita, M Maeda, Y Fujio, J Kima, J Fujitsu, S Kasayama, Yamamoto, I, J Azuma

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　Vol. 1673　No. 3　p. 115-121　2004/08　Research paper (scientific journal)

Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells

T Ito, Y Fujio, M Hirata, T Takatani, T Matsuda, S Muraoka, K Takahashi, J Azuma

BIOCHEMICAL JOURNAL　Vol. 382　p. 177-182　2004/08　Research paper (scientific journal)

Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma

HM Amin, TJ McDonnell, YP Ma, Q Lin, Y Fujio, K Kunisada, Leventaki, V, P Das, GZ Rassidakis, C Cutler, LJ Medeiros, R Lai

ONCOGENE　Vol. 23　No. 32　p. 5426-5434　2004/07　Research paper (scientific journal)

Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

R Lai, GZ Rassidakis, LJ Medeiros, L Ramdas, AH Goy, C Cutler, Y Fujio, K Kunisada, HM Amin, F Gilles

AMERICAN JOURNAL OF PATHOLOGY　Vol. 164　No. 6　p. 2251-2258　2004/06　Research paper (scientific journal)

Novel Insertional mutation in the bone morphogenetic protein receptor type II associated with sporadic primary pulmonary hypertension

S Sugiyama, H Hirota, M Yoshida, Y Takemura, Y Nakaoka, Y Shima, K Terai, M Izumi, Y Fujio, S Hasegawa, T Mano, Y Nakatsuchi, M Hori, K Yamauchi-Takihara, Kawase, I

CIRCULATION JOURNAL　Vol. 68　No. 6　p. 592-594　2004/06　Research paper (scientific journal)

Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway

T Takatani, K Takahashi, Y Uozumi, T Matsuda, T Ito, SW Schaffer, Y Fujio, J Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 316　No. 2　p. 484-489　2004/04　Research paper (scientific journal)

ヒト肝臓における核内受容体と薬物代謝酵素CYP3A4との遺伝子発現量に相関性があるか?

新宅 紗里, 福圓 修一, 福田 剛史, 松田 秀康, 松永 憲和, 高橋 京子, 藤尾 慈, 稲葉 忠信, 東 純一

臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS　Vol. 35　No. 1　2004/01/31

健常人におけるUGT1A1遺伝子多型と血清ビリルビン値変動について

松本 京子, 大野 雅子, 田邊 智子, 崎谷 薫太郎, 福田 剛史, 籾山 邦男, 藤尾 慈, 東 純一

臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS　Vol. 35　No. 1　2004/01/31

CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers

T. Fukuda, S. Onishi, S. Fukuen, Y. Ikenaga, M. Ohno, M. Ohno, K. Hoshino, K. Matsumoto, A. Maihara, K. Momiyama, T. Ito, Y. Fujio, J. Azuma

Pharmacogenomics Journal　Vol. 4　No. 1　p. 34-39　2004　Research paper (scientific journal)

Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages

M Maeda, Yamamoto, I, Y Fujio, J Azuma

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　Vol. 1623　No. 1　p. 41-46　2003/09　Research paper (scientific journal)

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes

Y Nakaoka, K Nishida, Y Fujio, M Izumi, K Terai, Y Oshima, S Sugiyama, S Matsuda, S Koyasu, K Yamauchi-Takihara, T Hirano, Kawase, I, H Hirota

CIRCULATION RESEARCH　Vol. 93　No. 3　p. 221-229　2003/08　Research paper (scientific journal)

Diabetic retinopathy possibly results from poor blood sugar control associated with MTHFR gene polymorphism in type 2 diabetic patients - Response to Yoshioka et al.

M Maeda, Yamamoto, I, M Fukuda, M Nishida, J Fujitsu, S Nonen, T Igarashi, T Motomura, M Inaba, Y Fujio, J Azuma

DIABETES CARE　Vol. 26　No. 6　p. 1948-1948　2003/06

MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation

M Maeda, Yamamoto, I, M Fukuda, M Nishida, J Fujitsu, S Nonen, T Igarashi, T Motomura, M Inaba, Y Fujio, J Azuma

DIABETES CARE　Vol. 26　No. 2　p. 547-548　2003/02

Nifedipineの薬物動態とCYP3A5遺伝子多型の関連性の検討 : 健常成人を対象として

大西 沙知, 福田 剛史, 福圓 修一, 池永 有香, 大野 雅子, 星野 こう子, 松本 京子, 舞原 章, 籾山 邦男, 小椋 盛孝, 金田 平八郎, 伊藤 忠雄, 藤尾 慈, 東 純一

臨床薬理　Vol. 34　No. 1　p. 117S-118S　2003/01/31

A novel role for cytokine signaling in cardiac remodeling

K Yamauchi-Takihara, H Hirota, Y Fujio, M Izumi, Y Oshima, Y Nakaoka

CARDIAC REMODELING AND FAILURE　Vol. 5　p. 259-264　2003　Research paper (international conference proceedings)

Specific cardiomyopathy caused by multisystemic lipid storage in Jordan's anomaly

Y Oshima, H Hirota, H Nagai, M Izumi, Y Nakaoka, T Osugi, Y Fujio, H Tateyama, M Kikui, K Yamauchi-Takihara, Kawase, I

CIRCULATION　Vol. 106　No. 2　p. 280-281　2002/07

Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

Y Oshima, Y Fujio, M Funamoto, S Negoro, M Izumi, Y Nakaoka, H Hirota, K Yamauchi-Takihara, Kawase, I

FEBS LETTERS　Vol. 524　No. 1-3　p. 123-126　2002/07　Research paper (scientific journal)

Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation

K Kunisada, E Tone, S Negoro, Y Nakaoka, Y Oshima, T Osugi, M Funamoto, M Izumi, Y Fujio, H Hirota, K Yamauchi-Takihara

CARDIOVASCULAR RESEARCH　Vol. 53　No. 4　p. 936-943　2002/03　Research paper (scientific journal)

A case of hypereosinophilic syndrome presenting mid-ventricular obstruction

Y Nakaoka, K Iwahori, K Kunisada, Y Fujio, M Izumi, T Osugi, Y Oshima, H Hirota, K Yamauchi-Takihara

HEART AND VESSELS　Vol. 16　No. 3　p. 121-124　2002/03　Research paper (scientific journal)

Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart

T Osugi, Y Oshima, Y Fujio, M Funamoto, A Yamashita, S Negoro, K Kunisada, M Izumi, Y Nakaoka, H Hirota, M Okabe, K Yamauchi-Takihara, Kawase, I, T Kishimoto

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 277　No. 8　p. 6676-6681　2002/02　Research paper (scientific journal)

Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation

Y Fujio, Y Mitsuuchi, Testa, JR, K Walsh

CELL DEATH AND DIFFERENTIATION　Vol. 8　No. 12　p. 1207-1212　2001/12　Research paper (scientific journal)

Protein kinase B/Akt activates c-Jun NH2-terminal kinase by increasing NO production in response to shear stress

YM Go, YC Boo, H Park, MC Maland, R Patel, KA Pritchard, Y Fujio, K Walsh, Darley-Usmar, V, H Jo

JOURNAL OF APPLIED PHYSIOLOGY　Vol. 91　No. 4　p. 1574-1581　2001/10　Research paper (scientific journal)

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase

S Negoro, K Kunisada, Y Fujio, M Funamoto, MI Darville, DL Eizirik, T Osugi, M Izumi, Y Oshima, Y Nakaoka, H Hirota, T Kishimoto, K Yamauchi-Takihara

CIRCULATION　Vol. 104　No. 9　p. 979-981　2001/08　Research paper (scientific journal)

Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway

M Izumi, Y Fujio, K Kunisada, S Negoro, E Tone, M Funamoto, T Osugi, Y Oshima, Y Nakaoka, T Kishimoto, K Yamauchi-Takihara, H Hirota

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 276　No. 33　p. 31133-31141　2001/08　Research paper (scientific journal)

beta-amyloid peptide expression is sufficient for myotube death: Implications for human inclusion body myopathy

HW Querfurth, T Suhara, KM Rosen, DL McPhie, Y Fujio, G Tejada, RL Neve, LS Adelman, K Walsh

MOLECULAR AND CELLULAR NEUROSCIENCE　Vol. 17　No. 5　p. 793-810　2001/05　Research paper (scientific journal)

Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies

M Zhang, D Methot, Poppa, V, Y Fujio, K Walsh, CE Murry

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 33　No. 5　p. 907-921　2001/05　Research paper (scientific journal)

Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction

S Negoro, H Oh, E Tone, K Kunisada, Y Fujio, K Walsh, T Kishimoto, K Yamauchi-Takihara

CIRCULATION　Vol. 103　No. 4　p. 555-561　2001/01　Research paper (scientific journal)

Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization

ML Hixon, C Muro-Cacho, MW Wagner, C Obejero-Paz, E Millie, Y Fujio, Y Kureishi, T Hassold, K Walsh, A Gualberto

JOURNAL OF CLINICAL INVESTIGATION　Vol. 106　No. 8　p. 1011-1020　2000/10　Research paper (scientific journal)

Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo

ZY Luo, Y Fujio, Y Kureishi, RD Rudic, G Daumerie, D Fulton, WC Sessa, K Walsh

JOURNAL OF CLINICAL INVESTIGATION　Vol. 106　No. 4　p. 493-499　2000/08　Research paper (scientific journal)

Isolation and characterization of the murine cardiotrophin-1 gene: Expression and norepinephrine-induced transcriptional activation

M Funamoto, S Hishinuma, Y Fujio, Y Matsuda, K Kunisada, H Oh, S Negoro, E Tone, T Kishimoto, K Yamauchi-Takihara

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 32　No. 7　p. 1275-1284　2000/07　Research paper (scientific journal)

Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt

M Morales-Ruiz, D Fulton, G Sowa, LR Languino, Y Fujio, K Walsh, WC Sessa

CIRCULATION RESEARCH　Vol. 86　No. 8　p. 892-896　2000/04　Research paper (scientific journal)

Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

M Funamoto, Y Fujio, K Kunisada, S Negoro, E Tone, T Osugi, H Hirota, M Izumi, K Yoshizaki, K Walsh, T Kishimoto, K Yamauchi-Takihara

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 275　No. 14　p. 10561-10566　2000/04　Research paper (scientific journal)

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart

Y Fujio, T Nguyen, D Wencker, RN Kitsis, K Walsh

CIRCULATION　Vol. 101　No. 6　p. 660-667　2000/02　Research paper (scientific journal)

Hypoxic stress induces cardiotrophin-1 expression in cardiac myocytes

S Hishinuma, M Funamoto, Y Fujio, K Kunisada, K Yamauchi-Takihara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 264　No. 2　p. 436-440　1999/10　Research paper (scientific journal)

Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells

M Ushio-Fukai, RW Alexander, M Akers, QQ Yin, Y Fujio, K Walsh, KK Griendling

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 32　p. 22699-22704　1999/08　Research paper (scientific journal)

Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival

Y Fujio, K Guo, T Mano, Y Mitsuuchi, Testa, JR, K Walsh

MOLECULAR AND CELLULAR BIOLOGY　Vol. 19　No. 7　p. 5073-5082　1999/07　Research paper (scientific journal)

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

D Fulton, JP Gratton, TJ McCabe, J Fontana, Y Fujio, K Walsh, TF Franke, A Papapetropoulos, WC Sessa

NATURE　Vol. 399　No. 6736　p. 597-601　1999/06　Research paper (scientific journal)

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

Y Fujio, K Walsh

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 274　No. 23　p. 16349-16354　1999/06　Research paper (scientific journal)

Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes

H Matsui, Y Ihara, Y Fujio, K Kunisada, S Akira, T Kishimoto, K Yamauchi-Takihara

CARDIOVASCULAR RESEARCH　Vol. 42　No. 1　p. 104-112　1999/04　Research paper (scientific journal)

Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes

E Tone, K Kunisada, Y Fujio, H Matsui, S Negoro, H Oh, T Kishimoto, K Yamauchi-Takihara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 253　No. 1　p. 147-150　1998/12　Research paper (scientific journal)

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes

K Kunisada, E Tone, Y Fujio, H Matsui, K Yamauchi-Takihara, T Kishimoto

CIRCULATION　Vol. 98　No. 4　p. 346-352　1998/07　Research paper (scientific journal)

Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes

H Oh, Y Fujio, K Kunisada, H Hirota, H Matsui, T Kishimoto, K Yamauchi-Takihara

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 273　No. 16　p. 9703-9710　1998/04　Research paper (scientific journal)

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes

Y Fujio, K Kunisada, H Hirota, K YamauchiTakihara, T Kishimoto

JOURNAL OF CLINICAL INVESTIGATION　Vol. 99　No. 12　p. 2898-2905　1997/06　Research paper (scientific journal)

Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy

C NakajimaTaniguchi, H Matsui, Y Fujio, S Nagata, T Kishimoto, K YamauchiTakihara

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 29　No. 2　p. 839-843　1997/02　Research paper (scientific journal)

Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes

K Kunisada, H Hirota, Y Fujio, H Matsui, Y Tani, K YamauchiTakihara, T Kishimoto

CIRCULATION　Vol. 94　No. 10　p. 2626-2632　1996/11　Research paper (scientific journal)

Leukemia inhibitory factor induces a hypertrophic response mediated by GP130 in murine cardiac myocytes

H Matsui, Y Fujio, K Kunisada, H Hirota, K YamauchiTakihara

RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY　Vol. 93　No. 2　p. 149-162　1996/08　Research paper (scientific journal)

Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene

K YamauchiTakihara, C NakajimaTaniguchi, H Matsui, Y Fujio, K Kunisada, S Nagata, T Kishimoto

HEART　Vol. 76　No. 1　p. 63-65　1996/07　Research paper (scientific journal)

Roles of gp130 signaling pathways in cardiac myocytes: Recent advances and implications for cardiovascular disease

Keiko Yamauchi-Takihara, Hisao Hirota, Keita Kunisada, Hideo Matsui, Yasushi Fujio, Tetsuya Taga, Tadamitsu Kishimoto

Journal of Cardiac Failure　Vol. 2　No. 1　p. S63-S67　1996　Research paper (scientific journal)

Elevated calcium level induces calcium-dependent proteolysis of A-CAM (N-cadherin) in heart - Analysis by detergent-treated model

N Sato, Y Fujio, F YamadaHonda, H Funai, A Wada, S Kawashima, N Awata, N Shibata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 217　No. 2　p. 649-653　1995/12　Research paper (scientific journal)

Disruption of cell-cell adhesion in an inbred strain of hereditary cardiomyopathic hamster (bio 14.6)

Y Fujio, F YamadaHonda, N Sato, H Funai, A Wada, N Awata, N Shibata

CARDIOVASCULAR RESEARCH　Vol. 30　No. 6　p. 899-904　1995/12　Research paper (scientific journal)

ALTERED FIBRONECTIN-DEPENDENT CELL-ADHESION BY PDGF ACCOMPANIES PHENOTYPIC MODULATION OF VASCULAR SMOOTH-MUSCLE CELLS

Y FUJIO, F YAMADA, K TAKAHASHI, N SHIBATA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 196　No. 2　p. 997-1002　1993/10　Research paper (scientific journal)

RESPONSES OF SMOOTH-MUSCLE CELLS TO PLATELET-DERIVED GROWTH-FACTOR ARE INHIBITED BY HERBIMYCIN-A TYROSINE KINASE INHIBITOR

Y FUJIO, F YAMADA, K TAKAHASHI, N SHIBATA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 195　No. 1　p. 79-83　1993/08　Research paper (scientific journal)

STRUCTURAL AND FUNCTIONAL-RELATIONSHIPS BETWEEN H-CALDESMONS AND L-CALDESMONS

K HAYASHI, Y FUJIO, KATO, I, K SOBUE

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 266　No. 1　p. 355-361　1991/01　Research paper (scientific journal)

Immunochemical evidence that myosin i heavy chain-like protein is identical to the 110-kilodalton brush-border protein

Minoru Hoshimaru, Yasushi Fujio, Kenji Sobue, Tetsuo Sugimoto, Shigetada Nakanishi

Journal of Biochemistry　Vol. 106　No. 3　p. 455-459　1989　Research paper (scientific journal)

Significances of two different Mr caldesmons.

Sobue K, Fujio Y

In Calcium Protein Signaling, Plenum Publishing Corporation　p. 325-335　1989

TUMOR PROMOTER INDUCES REORGANIZATION OF ACTIN-FILAMENTS AND CALSPECTIN (FODRIN OR NONERYTHROID SPECTRIN) IN 3T3 CELLS

K SOBUE, Y FUJIO, K KANDA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 85　No. 2　p. 482-486　1988/01　Research paper (scientific journal)

The Ca2+-dependent regulation of the submembranous cytoskeleton in nonerythroid cells: The possible involvement of calspectin (nonerythroid spectrin or fodrin) and its interacting proteins.

Sobue K, Okabe T, Itoh K, Kadowaki K, Tanaka T, Kanda K, Ueki N, Fujio Y

Biomed Res　Vol. 8　p. 13-22　1987

IMMUNOCYTOCHEMICAL LOCALIZATION OF CALSPECTIN (A NONERYTHROID SPECTRIN-LIKE PROTEIN) IN THYROID-GLANDS OF NORMAL AND TSH-TREATED RATS

K ISHIMURA, T SENDA, K KITAJIMA, H FUJITA, Y FUJIO, K SOBUE

HISTOCHEMISTRY　Vol. 86　No. 6　p. 537-539　1987　Research paper (scientific journal)