Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine

Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Takao Yamaguchi, Rintaro Iwata Hara, Tetsuya Nagata, Osamu Nakagawa, Satoshi Obika, Takanori Yokota

Mol. Ther. Nucleic Acids　Vol. 32　p. 102161-102161　2024　Research paper (scientific journal)

Comparison of Analysis Data of Model Oligonucleotide Therapeutics Obtained with Different Types of Liquid Chromatograph-Mass Spectrometers

Kenji Hirose, Tokuyuki Yoshida, Maki Terasaki, Hiroshi Sezaki, Kaoru Karasawa, Noriyuki Iwasaki, Kentaro Takahara, Naomi Takiguchi, Mitsuaki Sekiguchi, Hirokazu Nankai, Emi Saito, Hideaki Sato, Takashi Osawa, Takao Yamaguchi, Kosuke Ito, Junji Kawakami, Satoshi Obika, Takao Inoue

PMDRS　Vol. 54　p. 439-454　2023

Challenges of Impurities Analysis in Manufacturing Therapeutic Oligonucleotides

Ryutaro Takamine, Takao Yamaguchi

J. Mass Spectrom. Jpn.　Vol. 71　No. 2　p. 51-54　2023　Research paper (scientific journal)

Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study

Momoka Hayashida, Risa Suzuki, Shinnosuke Horie, Junichi Masuda, Takao Yamaguchi, Satoshi Obika

J. Chromatogr. A　2023　Research paper (scientific journal)

Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′-methylguanidine-bridged nucleic acids

Takao Yamaguchi, Naohiro Horie, Hiroshi Aoyama, Shinji Kumagai, Satoshi Obika

Nucleic Acids Res.　Vol. 51　p. 7749-7761　2023　Research paper (scientific journal)

Development of 8–17 XNAzymes that are functional in cells

Kosuke Chiba, Takao Yamaguchi, Satoshi Obika

Chem. Sci.　Vol. 14　p. 7620-7629　2023　Research paper (scientific journal)

Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities

Yuya Tanaka, Yurika Tanioku, Taisuke Nakayama, Kotomi Aso, Takao Yamaguchi, Haruhiko Kamada, Satoshi Obika

Bioorg. Med. Chem.　Vol. 81　2023　Research paper (scientific journal)

Retention behavior of short double-stranded oligonucleotide and its potential impurities by anion-exchange chromatography under non-denaturing conditions

Hiroyuki Togawa, Takashi Okubo, Yumi Nonaka, Takao Yamaguchi, Satoshi Obika

J. Chromatogr. A　2023　Research paper (scientific journal)

Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2′-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase

Yota Sakurai, Takao Yamaguchi, Tokuyuki Yoshida, Masahiko Horiba, Takao Inoue, Satoshi Obika

J. Org. Chem.　Vol. 88　p. 154-162　2023　Research paper (scientific journal)

Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides

Ryohei Yamaji, Osamu Nakagawa, Yuki Kishimoto, Akane Fujii, Tomoki Matsumura, Taisuke Nakayama, Haruhiko Kamada, Takashi Osawa, Takao Yamaguchi, Satoshi Obika

Bioorganic & medicinal chemistry　Vol. 72　2022　Research paper (scientific journal)

Physicochemical property evaluation of modified oligonucleotides by traveling‐wave ion mobility mass spectrometry

Shogo Omuro, Takao Yamaguchi, Taiji Kawase, Maki Terasaki, Kenji Hirose, Satoshi Obika

Rapid Communications in Mass Spectrometry　Vol. 36　No. 10　2022　Research paper (scientific journal)

Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach

Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara, Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E. Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, Takayoshi Suzuki

J. Med. Chem.　Vol. 64　p. 15810-15824　2021　Research paper (scientific journal)

Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA)

Takao Yamaguchi, Chika Yamamoto, Masahiko Horiba, Hiroshi Aoyama, Satoshi Obika

Bioorg. Med. Chem.　Vol. 46　2021　Research paper (scientific journal)

Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Naohiro Horie, Takao Yamaguchi, Shinji Kumagai, Satoshi Obika

Beilstein J. Org. Chem.　Vol. 17　p. 622-629　2021　Research paper (scientific journal)

Synthesis and Properties of GuNA Purine/Pyrimidine Nucleosides and Oligonucleotides

Shinji Kumagai, Hiroaki Sawamoto, Tomo Takegawa-Araki, Yuuki Arai, Shuhei Yamakoshi, Katsuya Yamada, Tetsuya Ohta, Eiji Kawanishi, Naohiro Horie, Takao Yamaguchi, Satoshi Obika

Org. Biomol. Chem.　No. 18　p. 9461-9472　2020

Synthesis and evaluation of artificial nucleic acid bearing an oxanorbornane scaffold

Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika

Molecules　Vol. 25　No. 7　2020　Research paper (scientific journal)

Different reactivity of Sp and Rp isomers of phosphorothioate-modified oligonucleotides in a duplex structure

Md Ariful Islam, Aki Fujisaka, Junji Kawakami, Takao Yamaguchi, Satoshi Obika

Bioorg. Med. Chem. Lett.　Vol. 30　2020　Research paper (scientific journal)

Synthesis and properties of oligonucleotides having ethynylphosphonate (EP) linkages

Masahiko Horiba, Takao Yamaguchi, Satoshi Obika

J. Org. Chem.　Vol. 85　p. 1794-1801　2020　Research paper (scientific journal)

Structure-activity relationship for the oxadiazole class of antibacterials

Marc A. Boudreau, Derong Ding, Jayda E. Meisel, Jeshina Janardhanan, Edward Spink, Zhihong Peng, Yuanyuan Qian, Takao Yamaguchi, Sebastian A. Testero, Peter I. O'Daniel, Erika Leemans, Elena Lastochkin, Wei Song, Valerie A. Schroeder, William R. Wolter, Mark A. Suckow, Shahriar Mobashery, Mayland Chang

ACS Med. Chem. Lett.　Vol. 11　p. 322-326　2020

Thymidine, 2-Thiothymidine, and 2-Selenothymidine: Comparison of Mismatch Discriminations

Takaki Habuchi, Takao Yamaguchi, Satoshi Obika

Heterocycles　Vol. 98　p. 832-837　2019

Detection of esterase activity by chromogenic and fluorogenic probe based on an O-nitrobenzoxadiazole (O-NBD) unit

Kana Okada, Takao Yamaguchi, Kosuke Dodo, Mikiko Sodeoka, Satoshi Obika

Bioorg. Med. Chem.　Vol. 27　p. 1444-1448　2019

Hybridization and mismatch discrimination abilities of 2′,4′-bridged nucleic acids bearing 2-thiothymine or 2-selenothymine nucleobase

Takaki Habuchi, Takao Yamaguchi, Hiroshi Aoyama, Masahiko Horiba, Kosuke Ramon Ito, Satoshi Obika

J. Org. Chem.　Vol. 84　p. 1430-1439　2019

Thioamide-bridged nucleic acid (thioAmNA) bearing thymine or 2-thiothymine: Duplex forming ability, base discrimination, and enzymatic stability

Takaki Habuchi, Takao Yamaguchi, Satoshi Obika

ChemBioChem　Vol. 20　p. 1060-1067　2019

Development of a novel affinity labeling method for the target identification of bioactive small molecules

Takao Yamaguchi

YAKUGAKU ZASSHI　Vol. 139　p. 1513-1521　2019

Derivative Synthesis toward Enhancement of the Biophysical Properties of 2′,4′-Bridged Nucleic Acids

Takao Yamaguchi, Satoshi Obika

J. Synth. Org. Chem.　Vol. 77　No. 10　p. 994-1004　2019　Research paper (scientific journal)

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe])

Naohiro Horie, Shinji Kumagai, Yutaro Kotobuki, Takao Yamaguchi, Satoshi Obika

Org. Biomol. Chem.　Vol. 16　p. 6531-6536　2018

Synthesis and biophysical properties of 5’-thio-2’,4’-BNA/LNA oligonucleotide

Md Ariful Islam, Aki Fujisaka, Shohei Mori, Kosuke Ramon Ito, Takao Yamaguchi, Satoshi Obika

Bioorg. Med. Chem.　Vol. 26　p. 3634-3638　2018

Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands

Ryuta Shioi, Yosuke Toyota, Tomomi Noguchi-Yachide, Minoru Ishikawa, Takao Yamaguchi, Makoto Makishima, Yuichi Hashimoto, Kenji Ohgane

Heterocycles　2018

Affinity Labeling with 4-Azidophthalimide (AzPI): Relation between Labeling Rate and Fluorescence Intensity

Kosuke Chiba, Yuichi Hashimoto, Takao Yamaguchi

Chem. Pharm. Bull.　Vol. 65　No. 10　p. 994-996　2017/10　Research paper (scientific journal)

Specific fluorescence labeling of target proteins by using a ligand-4-azidophthalimide conjugate

Kosuke Chiba, Miwako Asanuma, Minoru Ishikawa, Yuichi Hashimoto, Kosuke Dodo, Mikiko Sodeoka, Takao Yamaguchi

CHEMICAL COMMUNICATIONS　Vol. 53　No. 62　p. 8751-8754　2017/08　Research paper (scientific journal)

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

Seika Amemiya, Takao Yamaguchi, Yuichi Hashimoto, Tomomi Noguchi-Yachide

Bioorg. Med. Chem.　Vol. 25　No. 14　p. 3677-3684　2017/07　Research paper (scientific journal)

Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor alpha/delta (PPAR alpha/delta) dual agonists

Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　Vol. 27　No. 14　p. 3131-3134　2017/07　Research paper (scientific journal)

DEVELOPMENT OF N-6-(HETEROARYLCARBONYL)ADENINES AS BRD4 INHIBITORS

Seika Amemiya, Takao Yamaguchi, Yuichi Hashimoto, Tomomi Noguchi-Yachide

HETEROCYCLES　Vol. 94　No. 6　p. 1107-1114　2017/06　Research paper (scientific journal)

Photo-enhanced Aqueous Solubilization of an Azo-compound

Minoru Ishikawa, Takuya Ohzono, Takao Yamaguchi, Yasuo Norikane

Sci. Rep.　2017

STRUCTURAL DEVELOPMENT STUDIES OF PYRAZOLOKETONE-DERIVED ACETYL-CoA CARBOXYLASE INHIBITORS

Shogo Okazaki, Taki Sakai, Minoru Ishikawa, Yuichi Hashimoto, Takao Yamaguchi

HETEROCYCLES　Vol. 95　No. 1　p. 595-607　2017/01　Research paper (scientific journal)

Synthesis of scpBNA-C-m, -A, and -G Monomers and Evaluation of the Binding Affinities of scpBNA-Modified Oligonucleotides toward Complementary ssRNA and ssDNA

Masahiko Horiba, Takao Yamaguchi, Satoshi Obika

J. Org. Chem.　Vol. 81　No. 22　p. 11000-11008　2016/11　Research paper (scientific journal)

Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor alpha/delta (PPAR alpha/delta) dual agonists

Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 24　No. 21　p. 5455-5461　2016/11　Research paper (scientific journal)

Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor alpha/delta (PPAR alpha/delta) dual agonistic activity

Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi

BIOORGANIC & MEDICINAL CHEMISTRY　Vol. 24　No. 21　p. 5258-5269　2016/11　Research paper (scientific journal)

Dichloromaleimide (diCMI): A Small and Fluorogenic Reactive Group for Use in Affinity Labeling

Kosuke Chiba, Yuichi Hashimoto, Takao Yamaguchi

Chem. Pharm. Bull.　Vol. 64　No. 11　p. 1647-1653　2016/11　Research paper (scientific journal)

Structure-Activity Relationship Study of N-6-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-alpha Production

Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Noguchi-Yachide

CHEMICAL & PHARMACEUTICAL BULLETIN　Vol. 64　No. 9　p. 1378-1383　2016/09　Research paper (scientific journal)

Improvement in Aqueous Solubility of Retinoic Acid Receptor (RAR) Agonists by Bending the Molecular Structure

Michiaki Hiramatsu, Yuki Ichikawa, Shusuke Tomoshige, Makoto Makishima, Atsuya Muranaka, Masanobu Uchiyama, Takao Yamaguchi, Yuichi Hashimoto, Minoru Ishikawa

CHEMISTRY-AN ASIAN JOURNAL　Vol. 11　No. 15　p. 2210-2217　2016/08　Research paper (scientific journal)

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials

Erika Leemans, Kiran V. Mahasenan, Malika Kumarasiri, Edward Spink, Derong Ding, Peter I. O'Daniel, Marc A. Boudreau, Elena Lastochkin, Sebastian A. Testero, Takao Yamaguchi, Mijoon Lee, Dusan Hesek, Jed F. Fisher, Mayland Chang, Shahriar Mobashery

Bioorg. Med. Chem. Lett.　Vol. 26　No. 3　p. 1011-1015　2016/02　Research paper (scientific journal)

Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics

Derong Ding, Marc A. Boudreau, Erika Leemans, Edward Spink, Takao Yamaguchi, Sebastian A. Testero, Peter I. O'Daniel, Elena Lastochkin, Mayland Chang, Shahriar Mobashery

Bioorg. Med. Chem. Lett.　Vol. 25　No. 21　p. 4854-4857　2015/11　Research paper (scientific journal)

Synthesis and fluorescence properties of 4-diarylmethylene analogues of the green fluorescent protein chromophore

Masahiro Ikejiri, Kousuke Matsumoto, Hiraku Hasegawa, Daisuke Yamaguchi, Moe Tsuchino, Yoshiko Chihara, Takao Yamaguchi, Kazuto Mori, Takeshi Imanishi, Satoshi Obika, Kazuyuki Miyashita

TETRAHEDRON　Vol. 71　No. 30　p. 4987-4998　2015/07　Research paper (scientific journal)

Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors

Tomomi Noguchi-Yachide, Taki Sakai, Yuichi Hashimoto, Takao Yamaguchi

Bioorg. Med. Chem.　Vol. 23　No. 5　p. 953-959　2015/03　Research paper (scientific journal)

Synthesis and properties of 2 '-O,4 '-C-spirocyclo-propylene bridged nucleic acid (scpBNA), an analogue of 2 ',4 '-BNA/LNA bearing a cyclopropane ring

Takao Yamaguchi, Masahiko Horiba, Satoshi Obika

CHEMICAL COMMUNICATIONS　Vol. 51　No. 47　p. 9737-9740　2015　Research paper (scientific journal)

Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

Peter I. O'Daniel, Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lastochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery, Mayland Chang

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　Vol. 136　No. 9　p. 3664-3672　2014/03　Research paper (scientific journal)

Turn-ON fluorescent affinity labeling using a small bifunctional O-nitrobenzoxadiazole unit

Takao Yamaguchi, Miwako Asanuma, Shuichi Nakanishi, Yohei Saito, Masateru Okazaki, Kosuke Dodo, Mikiko Sodeoka

Chem. Sci.　Vol. 5　No. 3　p. 1021-1029　2014/03　Research paper (scientific journal)

Design and Concise Synthesis of a Novel Type of Green Fluorescent Protein Chromophore Analogue

Masahiro Ikejiri, Moe Tsuchino, Yoshiko Chihara, Takao Yamaguchi, Takeshi Imanishi, Satoshi Obika, Kazuyuki Miyashita

Org. Lett.　Vol. 14　No. 17　p. 4406-4409　2012/09　Research paper (scientific journal)

Inhibitors for Bacterial Cell-Wall Recycling

Takao Yamaguchi, Blas Blazquez, Dusan Hesek, Mijoon Lee, Leticia I. Llarrull, Bill Boggess, Allen G. Oliver, Jed F. Fisher, Shahriar Mobashery

ACS Med. Chem. Lett.　Vol. 3　No. 3　p. 238-242　2012/03　Research paper (scientific journal)

Synthesis and DNA cleavage evaluation of epoxypiperidine derivatives bearing a dehydroamino acid unit

Takao Yamaguchi, Yuji Kawada, Satoshi Obika, Takeshi Imanishi, Kazuyuki Miyashita

TETRAHEDRON　Vol. 66　No. 41　p. 8181-8188　2010/10　Research paper (scientific journal)

Sulfonylation-Induced N- to O-Acetyl Migration in 2-Acetamidoethanol Derivatives

Takao Yamaguchi, Dusan Hesek, Mijoon Lee, Allen G. Oliver, Shahriar Mobashery

J. Org. Chem.　Vol. 75　No. 10　p. 3515-3517　2010/05　Research paper (scientific journal)

Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline

Dusan Hesek, Mijoon Lee, Takao Yamaguchi, Bruce C. Noll, Shahriar Mobashery

J. Org. Chem.　Vol. 73　No. 18　p. 7349-7352　2008/09　Research paper (scientific journal)