Immunogenic Comparison of Nucleic Acid-Based Vaccines Administered by Pyro-Drive Jet Injector

Jiayu A. Tai, Tomoyuki Nishikawa, Hiroki Hayashi, Yu-Diao Kuan, Kunihiko Yamashita, Hironori Nakagami

Vaccines　Vol. 12　No. 7　p. 757-757　2024/07/09　Research paper (scientific journal)

Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy.

Yuri Nakashima, Katsuyuki Tanabe, Tomoyo Mifune, Takato Nakadoi, Hiroki Hayashi, Hironori Nakagami, Yasufumi Sato, Jun Wada

American journal of physiology. Renal physiology　Vol. 326　No. 6　2024/06/01　Research paper (scientific journal)

Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies.

Xiuyuan Lu, Hiroki Hayashi, Eri Ishikawa, Yukiko Takeuchi, Julian Vincent Tabora Dychiao, Hironori Nakagami, Sho Yamasaki

eLife　Vol. 12　2024/05/08　Research paper (scientific journal)

膵β細胞におけるドキソルビシン誘導性の老化に関する研究(Investigating Doxorubicin-Induced Senescence in Pancreatic β-Cells)

Yin Nanxiang, 高橋 利匡, 林 宏樹, 井原 拾得, 小原 僚一, 野里 陽一, 鷹見 洋一, 中神 啓徳, 山本 浩一

日本老年医学会雑誌　Vol. 61　No. Suppl.　p. 142-143　2024/05

Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine

Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Keishi Miyata, Daisuke Torigoe, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike

npj Vaccines　Vol. 8　No. 1　2023/11/01　Research paper (scientific journal)

Long Term Follow-Up Study of a Randomized, Open-Label, Uncontrolled, Phase I/II Study to Assess the Safety and Immunogenicity of Intramuscular and Intradermal Doses of COVID-19 DNA Vaccine (AG0302-COVID19).

Hironori Nakagami, Tetsuya Matsumoto, Kenji Takazawa, Hisakuni Sekino, Osamu Matsuoka, Satoshi Inoue, Hidetoshi Furuie, Ryuichi Morishita

Vaccines　Vol. 11　No. 10　2023/09/28　Research paper (scientific journal)

老化に伴う内在性αシヌクレインの発現低下はBACE1の上昇を介して血管内皮の老化を促進する

王 紫び, 鷹見 洋一, 中神 啓徳, 高橋 利匡, 野里 陽一, 武田 朱公, 竹屋 泰, 山本 浩一, 樂木 宏実

日本高血圧学会総会プログラム・抄録集　Vol. 45回　p. 362-362　2023/09

Acquisition of Humoral Immune Responses in Convalescent Japanese People with SARS-CoV-2 (COVID-19) Infection in 2021.

Koshiro Monzen, Takanori Watanabe, Toshihiro Okabe, Hisakuni Sekino, Hironori Nakagami, Ryuichi Morishita

Viruses　Vol. 15　No. 9　2023/08/30　Research paper (scientific journal)

Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction

Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Chin Yang Chang, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

Scientific Reports　Vol. 13　No. 1　2023/08/10　Research paper (scientific journal)

Impact of insufficient recovery of cerebral blood flow due to partial reperfusion on the pathophysiology of ischemic stroke in mice

Munehisa Shimamura, Chin yang Chang, Hiroki Hayashi, Satoshi Baba, Shota Yoshida, Hironori Nakagami

Neuroscience Letters　Vol. 810　p. 137370-137370　2023/07　Research paper (scientific journal)

R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.

Munehisa Shimamura, Hiroki Hayashi, Nan Ju, Shota Yoshida, Satoshi Baba, Tsutomu Sasaki, Hideki Mochizuki, Ryuichi Morishita, Hironori Nakagami

Stroke　Vol. 54　No. 6　p. 1606-1615　2023/06　Research paper (scientific journal)

Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry.

Yukari Maeda, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Hisaya Kato, Yoshiro Maezawa, Junji Kawashima, Kayo Yoshinaga, Mai Ishikawa, Akiko Sekiguchi, Sei-Ichiro Motegi, Hironori Nakagami, Yoshihiko Yamada, Shinji Tsukamoto, Akira Taniguchi, Ken Sugimoto, Yoichi Takami, Yukiko Shoda, Kunihiko Hashimoto, Toru Yoshimura, Asako Kogure, Daisuke Suzuki, Naoki Okubo, Takashi Yoshida, Kazuhisa Watanabe, Masafumi Kuzuya, Minoru Takemoto, Junko Oshima, Koutaro Yokote

Aging　Vol. 15　No. 9　p. 3273-3294　2023/05/01　Research paper (scientific journal)

プロレニンペプチドワクチンの遺伝子改変糖尿病ブタの網膜血管病変に対する効果

横田 陽匡, 林 宏樹, 高瀬 公陽, 花栗 潤哉, 大野 皓, 丸山 高史, 阿部 雅紀, 櫛山 櫻, 櫛山 暁史, 中神 啓徳, 山上 聡, 長岡 泰司

日本眼科学会雑誌　Vol. 127　No. 臨増　p. 205-205　2023/03

Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats

Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi, Tetsuya Tomita, Hironori Nakagami

RMD Open　Vol. 9　No. 1　p. e002851-e002851　2023/02　Research paper (scientific journal)

High-Fat Diet-Induced Diabetic Conditions Exacerbate Cognitive Impairment in a Mouse Model of Alzheimer’s Disease Via a Specific Tau Phosphorylation Pattern

Y. Ito, S. Takeda, T. Nakajima, A. Oyama, H. Takeshita, K. Miki, Y. Takami, Y. Takeya, M. Shimamura, H. Rakugi, R. Morishita

The Journal Of Prevention of Alzheimer's Disease　2023　Research paper (scientific journal)

Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study.

Hiroshi Akasaka, Hironori Nakagami, Ken Sugimoto, Yukiko Yasunobe, Tomohiro Minami, Taku Fujimoto, Koichi Yamamoto, Chikako Hara, Akihiko Shiraki, Kohji Nishida, Kento Asano, Masanobu Kanou, Kei Yamana, Shin-Ichiro Imai, Hiromi Rakugi

Geriatrics & Gerontology International　Vol. 23　No. 1　p. 38-43　2023/01　Research paper (scientific journal)

Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant

Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Miwa Sasai, Chin Yang Chang, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Hiromi Rakugi, Ryuichi Morishita, Masahiro Yamamoto, Hironori Nakagami

Scientific Reports　Vol. 12　No. 1　2022/12/03　Research paper (scientific journal)

Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice

Nan Ju, Hiroki Hayashi, Munehisa Shimamura, Satoshi Baba, Shota Yoshida, Ryuichi Morishita, Hiromi Rakugi, Hironori Nakagami

Scientific Reports　Vol. 12　No. 1　p. 12474-12474　2022/12　Research paper (scientific journal)

Morning surge in sympathetic nervous activity in the indoor environment during the cold winter season.

Hironori Nakagami, Hitoshi Akiyama, Hiroki Otsuka, Sho Adnas Takahashi, Katsutoshi Sawada, Nobutoshi Kobayashi, Atsushi Iwamae, Hidekazu Yamada

Hypertension research : official journal of the Japanese Society of Hypertension　2022/10/13　Research paper (scientific journal)

New wave of digital hypertension management for clinical applications.

Hironori Nakagami

Hypertension research : official journal of the Japanese Society of Hypertension　Vol. 45　No. 10　p. 1549-1551　2022/10　Research paper (scientific journal)

Novel pathophysiological roles of α‐synuclein in age‐related vascular endothelial dysfunction

Yoichi Takami, Cheng Wang, Hironori Nakagami, Koichi Yamamoto, Yoichi Nozato, Yuki Imaizumi, Motonori Nagasawa, Hikari Takeshita, Tsuneo Nakajima, Shuko Takeda, Yasushi Takeya, Yasufumi Kaneda, Hiromi Rakugi

The FASEB Journal　Vol. 36　No. 10　2022/10　Research paper (scientific journal)

Preclinical study of a DNA vaccine targeting SARS-CoV-2

Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Ritsuko Kubota-Koketsu, Tatsuo Shioda, Chikako Ono, Yoshiharu Matsuura, Hisashi Arase, Shota Yoshida, Ryo Nakamaru, Nan Ju, Ryoko Ide, Akiko Tenma, Sotaro Kawabata, Takako Ehara, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Sachiko Okamoto, Yasunori Amaishi, Hideto Chono, Junichi Mineno, Takao Komatsuno, Yoshimi Saito, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

Current Research in Translational Medicine　Vol. 70　No. 4　p. 103348-103348　2022/09　Research paper (scientific journal)

Phase I Study to Assess the Safety and Immunogenicity of an Intradermal COVID-19 DNA Vaccine Administered Using a Pyro-Drive Jet Injector in Healthy Adults.

Hironori Nakagami, Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Futoshi Nakagami, Shigeto Hamaguchi, Hisao Yoshida, Hideo Okuno, Shota Yoshida, Ryo Nakamaru, Serina Yokoyama, Taku Fujimoto, Kazuhiro Hongyo, Yukihiro Akeda, Ryuichi Morishita, Kazunori Tomono, Hiromi Rakugi

Vaccines　Vol. 10　No. 9　2022/08/30　Research paper (scientific journal)

Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation.

Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A Tai, Hiroki Hayashi, Jiao Sun, Shiho Torii, Chikako Ono, Yoshiharu Matsuura, Ryoko Ide, Junichi Mineno, Miwa Sasai, Masahiro Yamamoto, Hironori Nakagami, Kunihiko Yamashita

Immunological medicine　Vol. 45　No. 4　p. 1-14　2022/08/24　Research paper (scientific journal)

脳梗塞急性期治療のパラダイムシフト 炎症制御をターゲットにした急性期脳梗塞の創薬研究

島村 宗尚, 中神 啓徳, 佐々木 勉, 望月 秀樹

神経治療学　Vol. 39　No. 4　p. 517-521　2022/07

Blood pressure fluctuations and the indoor environment in a highly insulated and airtight model house during the cold winter season.

Hironori Nakagami, Hiroshi Akiyama, Hiroki Otsuka, Atsushi Iwamae, Hidekazu Yamada

Hypertension research : official journal of the Japanese Society of Hypertension　Vol. 45　No. 7　p. 1217-1219　2022/07　Research paper (scientific journal)

Author Correction: A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction.

Takahiro Kitsuka, Aya Shiraki, Jun-Ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node

Scientific reports　Vol. 12　No. 1　p. 7737-7737　2022/05/11　Research paper (scientific journal)

A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction.

Takahiro Kitsuka, Aya Shiraki, Jun-Ichi Oyama, Hironori Nakagami, Atsushi Tanaka, Koichi Node

Scientific reports　Vol. 12　No. 1　p. 6923-6923　2022/04/28　Research paper (scientific journal)

プロレニンペプチドワクチンの血清、房水中の抗体価

横田 陽匡, 林 宏樹, 高瀬 公陽, 花栗 潤哉, 渡部 昌久, 大野 皓, 小熊 英隆, 丸山 高史, 阿部 雅紀, 櫛山 暁史, 中神 啓徳, 山上 聡, 長岡 泰司

日本眼科学会雑誌　Vol. 126　No. 臨増　p. 169-169　2022/03

眼科検査・治療の低侵襲化 糖尿病網膜症診療の低侵襲化への挑戦

長岡 泰司, 横田 陽匡, 花栗 潤哉, 渡部 昌久, 朝生 浩, 花崎 浩継, 秋山 彩香, 大野 皓, 高瀬 公陽, 山上 聡, 櫛山 暁史, 櫛山 櫻, 長井 紀章, 中神 啓徳, 林 宏樹, 相原 一, 本庄 恵, 蔵野 信, 矢冨 裕, 五十嵐 浩二

日本眼科学会雑誌　Vol. 126　No. 3　p. 358-387　2022/03

RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.

Ryerson Fonseca Mota, Paulo Henrique Cavalcanti de Araújo, Maria Eduarda Ramos Cezine, Flávia Sayuri Matsuo, Rodrigo Jair Morandi Metzner, Carlos Alberto Oliveira de Biagi Junior, Kamila Chagas Peronni, Hiroki Hayashi, Munehisa Shimamura, Hironori Nakagami, Mariana Kiomy Osako

BioMed research international　Vol. 2022　p. 7740079-7740079　2022　Research paper (scientific journal)

Immunogenicity of SARS-CoV-2 vaccination in adolescents with cardiac disease.

Hiroki Hayashi, Jun Narita, Ryo Ishii, Masaki Hirose, Kazuhisa Hashimoto, Yoshiaki Yamagishi, Keiichi Ozono, Hironori Nakagami, Hidekazu Ishida

Pediatrics international : official journal of the Japan Pediatric Society　Vol. 64　No. 1　2022/01　Research paper (scientific journal)

Brief report on a phase I/IIa study to assess the safety, tolerability, and immune response of AGMG0201 in patients with essential hypertension.

Hironori Nakagami, Tetsuya Ishihama, Yuichi Daikyoji, Chieka Sasakura, Ei Yamada, Ryuichi Morishita

Hypertension research : official journal of the Japanese Society of Hypertension　Vol. 45　No. 1　p. 61-65　2022/01　Research paper (scientific journal)

Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes.

Harumasa Yokota, Hiroki Hayashi, Junya Hanaguri, Satoru Yamagami, Akifumi Kushiyama, Hironori Nakagami, Taiji Nagaoka

PloS one　Vol. 17　No. 1　2022　Research paper (scientific journal)

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.

Xiuyuan Lu, Yuki Hosono, Masamichi Nagae, Shigenari Ishizuka, Eri Ishikawa, Daisuke Motooka, Yuki Ozaki, Nicolas Sax, Yuichi Maeda, Yasuhiro Kato, Takayoshi Morita, Ryo Shinnakasu, Takeshi Inoue, Taishi Onodera, Takayuki Matsumura, Masaharu Shinkai, Takashi Sato, Shota Nakamura, Shunsuke Mori, Teru Kanda, Emi E Nakayama, Tatsuo Shioda, Tomohiro Kurosaki, Kiyoshi Takeda, Atsushi Kumanogoh, Hisashi Arase, Hironori Nakagami, Kazuo Yamashita, Yoshimasa Takahashi, Sho Yamasaki

The Journal of experimental medicine　Vol. 218　No. 12　2021/12/06　Research paper (scientific journal)

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

Masayoshi Suda, Ippei Shimizu, Goro Katsuumi, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Naomi Matsumoto, Yutaka Yoshida, Ryuta Mikawa, Akihiro Katayama, Jun Wada, Masahide Seki, Yutaka Suzuki, Atsushi Iwama, Hironori Nakagami, Ayako Nagasawa, Ryuichi Morishita, Masataka Sugimoto, Shujiro Okuda, Masanori Tsuchida, Kazuyuki Ozaki, Mayumi Nakanishi-Matsui, Tohru Minamino

Nature Aging　Vol. 1　No. 12　p. 1117-1126　2021/12　Research paper (scientific journal)

Prevention of vascular dementia via immunotherapeutic blockade of renin-angiotensin system in a rat model.

Kouji Wakayama, Munehisa Shimamura, Shota Yoshida, Hiroki Hayashi, Nan Ju, Hironori Nakagami, Ryuichi Morishita

Brain research　Vol. 1772　p. 147667-147667　2021/12/01　Research paper (scientific journal)

Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia.

Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Takashige Kuwabara, Keishi Miyata, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike

Cell reports. Medicine　Vol. 2　No. 11　p. 100446-100446　2021/11/16　Research paper (scientific journal)

Development of COVID-19 vaccines utilizing gene therapy technology.

Hironori Nakagami

International immunology　Vol. 33　No. 10　p. 521-527　2021/09/25　Research paper (scientific journal)

Therapeutic vaccine for chronic diseases after the COVID-19 Era.

Hironori Nakagami, Hiroki Hayashi, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

Hypertension research : official journal of the Japanese Society of Hypertension　Vol. 44　No. 9　p. 1047-1053　2021/09　Research paper (scientific journal)

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines

Yafei Liu, Noriko Arase, Jun-ichi Kishikawa, Mika Hirose, Songling Li, Asa Tada, Sumiko Matsuoka, Akemi Arakawa, Kanako Akamatsu, Chikako Ono, Hui Jin, Kazuki Kishida, Wataru Nakai, Masako Kohyama, Atsushi Nakagawa, Yoshiaki Yamagishi, Hironori Nakagami, Atsushi Kumanogoh, Yoshiharu Matsuura, Daron M. Standley, Takayuki Kato, Masato Okada, Manabu Fujimoto, Hisashi Arase

2021/08/23

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.

Yafei Liu, Wai Tuck Soh, Jun-Ichi Kishikawa, Mika Hirose, Emi E Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Atsushi Nakagawa, Takayuki Kato, Masato Okada, Daron M Standley, Tatsuo Shioda, Hisashi Arase

Cell　Vol. 184　No. 13　p. 3452-3466　2021/06/24　Research paper (scientific journal)

Prevention of Acute Lung Injury by a Novel CD14-Inhibitory Receptor Activator of the NF-κB Ligand Peptide in Mice

Nan Ju, Hiroki Hayashi, Munehisa Shimamura, Shota Yoshida, Ryo Nakamaru, Hironori Nakagami, Ryuichi Morishita, Hiromi Rakugi

ImmunoHorizons　Vol. 5　No. 6　p. 438-447　2021/06/15　Research paper (scientific journal)

Effect of prorenin peptide vaccine on an early phase of diabetic retinopathy in murine model of type 2 diabetes mellitu

Harumasa Yokota, Hiroki Hayashi, Junya Hanaguri, Satoru Yamagami, Fumiaki Kushiyama, Hironori Nakagami, Taiji Nagaoka

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　Vol. 62　No. 8　2021/06

Development of anti-thrombotic vaccine against human S100A9 in rhesus monkey.

Munehisa Shimamura, Koichi Kaikita, Hironori Nakagami, Tomohiro Kawano, Nan Ju, Hiroki Hayashi, Ryo Nakamaru, Shota Yoshida, Tsutomu Sasaki, Hideki Mochizuki, Kenichi Tsujita, Ryuichi Morishita

Scientific reports　Vol. 11　No. 1　p. 11472-11472　2021/06/01　Research paper (scientific journal)

CD153 VACCINE IS A NOVEL SENOTHERAPEUTIC OPTION FOR REMOVING SENESCENCE-ASSOCIATED T CELLS

Hironori Nakagami, Shota Yoshida, Ryuichi Morishita, Hiromi Rakugi

JOURNAL OF HYPERTENSION　Vol. 39　p. E286-E286　2021/04

NOVEL PATHOPHYSIOLOGICAL ROLES OF ALPHA-SYNUCLEIN (SNCA) IN AGE-RELATED VASCULAR ENDOTHELIAL DYSFUNCTION

Yoichi Takami, Hironori Nakagami, Koichi Yamamoto, Yasushi Takeya, Ryuichi Morishita, Shuko Takeda, Yasufumi Kaneda, Hiromi Rakugi

JOURNAL OF HYPERTENSION　Vol. 39　p. E179-E179　2021/04

SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals.

Shota Yoshida, Chikako Ono, Hiroki Hayashi, Shinya Fukumoto, Satoshi Shiraishi, Kazunori Tomono, Hisashi Arase, Yoshiharu Matsuura, Hironori Nakagami

Scientific reports　Vol. 11　No. 1　p. 5934-5934　2021/03/15　Research paper (scientific journal)

Performance Index for Types of Clinical Research Support Service Providers for Academic Research Organizations in Japan: A Cross-Sectional Survey.

Keiko Ueda, Naoto Uemura, Kotone Matsuyama, Yuji Nishizaki, Nanae Tanemura, Kento Asano, Yuki Otsuka, Naotake Yanagisawa, Toshiaki Otsuka, Shinji Yasuno, Rieko Ueda, Yumiko Seo, Hironori Nakagami, Shoji Sanada

Clinical and translational science　Vol. 14　No. 2　p. 745-755　2021/03　Research paper (scientific journal)

Management guideline for Werner syndrome 2020. 5. Infection associated with Werner syndrome.

Toshibumi Taniguchi, Minoru Takemoto, Yoshitaka Kubota, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Seijiro Mori, Kazuhisa Tsukamoto, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 150-152　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020. 7. Skin ulcer associated with Werner syndrome: Dermatological treatment.

Sei-Ichiro Motegi, Minoru Takemoto, Toshibumi Taniguchi, Yoshitaka Kubota, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Seijiro Mori, Kazuhisa Tsukamoto, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 160-162　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020. 4. Osteoporosis associated with Werner syndrome.

Seijiro Mori, Minoru Takemoto, Yoshitaka Kubota, Toshibumi Taniguchi, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Kazuhisa Tsukamoto, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 146-149　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome.

Masafumi Kuzuya, Minoru Takemoto, Yoshitaka Kubota, Toshibumi Taniguchi, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Seijiro Mori, Kazuhisa Tsukamoto, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 139-141　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome.

Minoru Takemoto, Yoshitaka Kubota, Toshibumi Taniguchi, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Kazuhisa Tsukamoto, Seijiro Mori, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 142-145　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020. 6. Skin ulcers associated with Werner syndrome: Prevention and non-surgical and surgical treatment.

Yoshitaka Kubota, Minoru Takemoto, Toshibumi Taniguchi, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Seijiro Mori, Kazuhisa Tsukamoto, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 153-159　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020 1. Dyslipidemia and fatty liver associated with Werner syndrome.

Kazuhisa Tsukamoto, Minoru Takemoto, Yoshitaka Kubota, Toshibumi Taniguchi, Sei-Ichiro Motegi, Akira Taniguchi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Seijiro Mori, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 133-138　2021/02　Research paper (scientific journal)

Management guideline for Werner syndrome 2020 8. Calcification in tendons associated with Werner syndrome.

Akira Taniguchi, Yasuhito Tanaka, Minoru Takemoto, Yoshitaka Kubota, Toshibumi Taniguchi, Sei-Ichiro Motegi, Hironori Nakagami, Yoshiro Maezawa, Masaya Koshizaka, Hisaya Kato, Kazuhisa Tsukamoto, Seijiro Mori, Masafumi Kuzuya, Koutaro Yokote

Geriatrics & gerontology international　Vol. 21　No. 2　p. 163-165　2021/02　Research paper (scientific journal)

Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A Tai, Hiroki Hayashi, Jiao Sun, Shiho Torii, Chikako Ono, Yoshiharu Matsuura, Ryoko Ide, Junichi Mineno, Miwa Sasai, Masahiro Yamamoto, Hironori Nakagami, Kunihiko Yamashita

2021/01/14

A novel angiotensin II peptide vaccine without an adjuvant in mice.

Ryo Nakamaru, Hironori Nakagami, Hiroki Hayashi, Jiao Sun, Akiko Tenma, Koichi Yamamoto, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi

Journal of hypertension　Vol. 39　No. 1　p. 181-189　2021/01　Research paper (scientific journal)

Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan.

Masaya Koshizaka, Yoshiro Maezawa, Yukari Maeda, Mayumi Shoji, Hisaya Kato, Hiyori Kaneko, Takahiro Ishikawa, Daisuke Kinoshita, Kazuki Kobayashi, Junji Kawashima, Akiko Sekiguchi, Sei-Ichiro Motegi, Hironori Nakagami, Yoshihiko Yamada, Shinji Tsukamoto, Akira Taniguchi, Ken Sugimoto, Yukiko Shoda, Kunihiko Hashimoto, Toru Yoshimura, Daisuke Suzuki, Masafumi Kuzuya, Minoru Takemoto, Koutaro Yokote

Aging　Vol. 12　No. 24　p. 24940-24956　2020/12/29　Research paper (scientific journal)

Prevention of Progression of Aortic Aneurysm by Peptide Vaccine Against Ang II (Angiotensin II) in a Rat Model.

Tomohiro Kurashiki, Takashi Miyake, Hironori Nakagami, Motonobu Nishimura, Ryuichi Morishita

Hypertension (Dallas, Tex. : 1979)　Vol. 76　No. 6　p. 1879-1888　2020/12　Research paper (scientific journal)

Future Directions of Therapeutic Vaccines for Chronic Diseases.

Ryo Nakamaru, Hironori Nakagami, Hiromi Rakugi, Ryuichi Morishita

Circulation journal : official journal of the Japanese Circulation Society　Vol. 84　No. 11　p. 1895-1902　2020/10/23　Research paper (scientific journal)

Progress of Gene Therapy in Cardiovascular Disease.

Munehisa Shimamura, Hironori Nakagami, Fumihiro Sanada, Ryuichi Morishita

Hypertension (Dallas, Tex. : 1979)　Vol. 76　No. 4　p. 1038-1044　2020/10　Research paper (scientific journal)

脊椎関節炎をターゲットとしたIL17Aワクチンの薬効の検討

林 宏樹, 孫 嬌, 柳田 結花, 冨田 哲也, 森下 竜一, 中神 啓徳

日本抗加齢医学会総会プログラム・抄録集　Vol. 20回　p. 240-240　2020/09

Antiproliferative Effects of Monoclonal Antibodies against (Pro)Renin Receptor in Pancreatic Ductal Adenocarcinoma.

Asadur Rahman, Makoto Matsuyama, Akio Ebihara, Yuki Shibayama, Arif Ul Hasan, Hironori Nakagami, Fumiaki Suzuki, Jiao Sun, Tomoe Kobayashi, Hiroki Hayashi, Daisuke Nakano, Hideki Kobara, Tsutomu Masaki, Akira Nishiyama

Molecular cancer therapeutics　Vol. 19　No. 9　p. 1844-1855　2020/09　Research paper (scientific journal)

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice.

Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi

Nature communications　Vol. 11　No. 1　p. 2482-2482　2020/05/18　Research paper (scientific journal)

Further Development and Intra-Laboratory Validation of a Novel Pyro-Drive Jet Injector (PJI)

Kunihiko Yamashita, Chinyang Chang, Jiayu A. Tai, Jiao Sun, Hiroki Hayashi, Hiroshi Miyazaki, Hironori Nakagami, Yasufumi Kaneda

MOLECULAR THERAPY　Vol. 28　No. 4　p. 294-294　2020/04

[Current status and perspectives in the development of therapeutic agents targeting post-ischemic inflammation in the acute stage of stroke].

Munehisa Shimamura, Hironori Nakagami, Tsutomu Sasaki, Ryuichi Morishita, Hideki Mochizuki

Rinsho shinkeigaku = Clinical neurology　Vol. 60　No. 4　p. 253-259　2020/03/31　Research paper (scientific journal)

Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice.

Hiroshi Koriyama, Yuka Ikeda, Hironori Nakagami, Munehisa Shimamura, Shota Yoshida, Hiromi Rakugi, Ryuichi Morishita

Vaccines　Vol. 8　No. 1　2020/02/12　Research paper (scientific journal)

The Efficacy of Angiotensin II Peptide Vaccination Against White Matter Lesions of Vascular Dementia in Rats

Kouji Wakayama, Munehisa Shimamura, Hironori Nakagami, Ryuichi Morishita

STROKE　Vol. 51　2020/02

Cellular senescence and senescence-associated T cells as a potential therapeutic target.

Hironori Nakagami

Geriatrics & gerontology international　Vol. 20　No. 2　p. 97-100　2020/02　Research paper (scientific journal)

Overview: New concept of therapeutic vaccines

Hironori Nakagami, Ryuichi Morishita

Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts　p. 1-8　2020/01/01　Part of collection (book)

A vaccine for ischemic stroke

Munehisa Shimamura, Tomohiro Kawano, Kouji Wakayama, Hironori Nakagami

Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts　p. 21-32　2020/01/01　Part of collection (book)

Closing: Clinical applications of therapeutic vaccines in the near future

Hironori Nakagami, Ryuichi Morishita

Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts　p. 73-79　2020/01/01　Part of collection (book)

Combined Analysis of Clinical Data on HGF Gene Therapy to Treat Critical Limb Ischemia in Japan.

Ryuichi Morishita, Munehisa Shimamura, Yasushi Takeya, Hironori Nakagami, Mitsuaki Chujo, Tetsuya Ishihama, Ei Yamada, Hiromi Rakugi

Current gene therapy　Vol. 20　No. 1　p. 25-35　2020　Research paper (scientific journal)

Novel properties of myoferlin in glucose metabolism via pathways involving modulation of adipose functions.

Nozato Y, Takami Y, Yamamoto K, Nagasawa M, Nozato S, Imaizumi Y, Takeshita H, Cheng W, Ito Y, Takeda S, Takeya Y, Sugimoto K, Nakagami H, Hanayama R, Rakugi H

FASEB J.　Vol. 34　No. 2　p. 2792-2811　2020/01　Research paper (scientific journal)

Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector.

Chinyang Chang, Jiao Sun, Hiroki Hayashi, Ayano Suzuki, Yuko Sakaguchi, Hiroshi Miyazaki, Tomoyuki Nishikawa, Hironori Nakagami, Kunihiko Yamashita, Yasufumi Kaneda

AAPS PharmSciTech　Vol. 21　No. 1　p. 19-19　2019/12/09　Research paper (scientific journal)

AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine.

Akiko Tenma, Hironori Nakagami, Hideki Tomioka, Makoto Sakaguchi, Ryoko Ide, Hiroshi Koriyama, Hiroki Hayashi, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

FASEB bioAdvances　Vol. 1　No. 12　p. 760-772　2019/12　Research paper (scientific journal)

Investigator-initiated clinical study of a functional peptide, SR-0379, for limb ulcers of patients with Werner syndrome as a pilot study.

Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Masaya Koshizaka, Taku Fujimoto, Eiji Kiyohara, Misa Hayashi, Yukinobu Nakagawa, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Koutaro Yokote, Hiromi Rakugi

Geriatrics & gerontology international　Vol. 19　No. 11　p. 1118-1123　2019/11　Research paper (scientific journal)

Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.

Nan Ju, Munehisa Shimamura, Hiroki Hayashi, Yuka Ikeda, Shota Yoshida, Ayumi Nakamura, Ryuichi Morishita, Hiromi Rakugi, Hironori Nakagami

Scientific reports　Vol. 9　No. 1　p. 15434-15434　2019/10/28　Research paper (scientific journal)

Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study.

Maeda S, Takeya Y, Oguro R, Akasaka H, Ryuno H, Kabayama M, Yokoyama S, Nagasawa M, Fujimoto T, Takeda M, Onishi-Takeya M, Itoh N, Takami Y, Yamamoto K, Sugimoto K, Inagaki H, Ogawa M, Nakagawa T, Yasumoto S, Masui Y, Arai Y, Ishizaki T, Ikebe K, Gondo Y, Kamide K, Rakugi H

Geriatrics & gerontology international　Vol. 19　No. 10　p. 967-971　2019/10　Research paper (scientific journal)

A vaccine targeting blood clot formation: what is the potential?

Shimamura M, Nakagami H

Expert review of vaccines　Vol. 18　No. 5　p. 419-421　2019/05

Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity.

Yohko Yoshida, Ippei Shimizu, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Takayuki Wakasugi, Masaaki Nakao, Hironori Nakagami, Ryuichi Morishita, Tohru Minamino

Scientific reports　Vol. 9　No. 1　p. 3858-3858　2019/03/07　Research paper (scientific journal)

Association between long-term care and chronic and lifestyle-related disease modified by social profiles in community-dwelling people aged 80 and 90; SONIC study.

Kiyoshige E, Kabayama M, Gondo Y, Masui Y, Ryuno H, Sawayama Y, Inoue T, Akagi Y, Sekiguchi T, Tanaka K, Nakagawa T, Yasumoto S, Ogawa M, Inagaki H, Oguro R, Sugimoto K, Akasaka H, Yamamoto K, Takeya Y, Takami Y, Itoh N, Takeda M, Nagasawa M, Yokoyama S, Maeda S, Ikebe K, Arai Y, Ishizaki T, Rakugi H, Kamide K

Archives of gerontology and geriatrics　Vol. 81　p. 176-181　2019/03　Research paper (scientific journal)

Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality.

Chun-Ming Shih, Feng-Yen Lin, Jong-Shiuan Yeh, Yi-Wen Lin, Shih-Hurng Loh, Nai-Wen Tsao, Hironori Nakagami, Ryuichi Morishita, Tatsuya Sawamura, Chi-Yuan Li, Cheng-Yen Lin, Chun-Yao Huang

Translational research : the journal of laboratory and clinical medicine　Vol. 205　p. 17-32　2019/03　Research paper (scientific journal)

[Development of therapeutic vaccine for life style-related diseases].

Hironori Nakagami

Nihon yakurigaku zasshi. Folia pharmacologica Japonica　Vol. 154　No. 5　p. 270-274　2019　Research paper (scientific journal)

Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice.

Kawano T, Shimamura M, Nakagami H, Kanki H, Sasaki T, Mochizuki H

PloS one　Vol. 14　No. 5　2019　Research paper (scientific journal)

Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis.

Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, Takeshita H, Wang C, Yokoyama S, Hayashi H, Hongyo K, Akasaka H, Takeya Y, Sugimoto K, Nakagami H, Rakugi H

Biochemical and biophysical research communications　Vol. 508　No. 4　p. 1168-1174　2019/01　Research paper (scientific journal)

新規機能性ペプチドを用いた皮膚潰瘍治療薬の臨床開発

中神 啓徳, 杉本 研, 鷹見 洋一, 藤本 拓, 樂木 宏実

日本内分泌学会雑誌　Vol. 94　No. 4　p. 1560-1560　2018/12

Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.

Shimamura M, Nakagami H, Shimizu H, Mukai H, Watanabe R, Okuzono T, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Ju N, Mochizuki H, Morishita R

Scientific reports　Vol. 8　No. 1　p. 17770-17770　2018/12　Research paper (scientific journal)

Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice.

Kawano T, Shimamura M, Nakagami H, Iso T, Koriyama H, Takeda S, Baba K, Sasaki T, Sakaguchi M, Morishita R, Mochizuki H

Hypertension (Dallas, Tex. : 1979)　Vol. 72　No. 6　p. 1355-1364　2018/12　Research paper (scientific journal)

Recent Advances in Therapeutic Vaccines to Treat Hypertension.

Hironori Nakagami, Ryuichi Morishita

Hypertension (Dallas, Tex. : 1979)　Vol. 72　No. 5　p. 1031-1036　2018/11　Research paper (scientific journal)

MYOFERLIN-MEDIATED LYSOSOMAL EXOCYTOSIS OF MACROPHAGE REGULATES OBESITY-INDUCED ADIPOSE INFLAMMATION

Yoichi Nozato, Yoichi Takami, Hironori Nakagami, Koichi Yamamoto, Rikinari Hanayama

JOURNAL OF HYPERTENSION　Vol. 36　p. E80-E80　2018/10

Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.

Hikari Takeshita, Koichi Yamamoto, Satoko Nozato, Masao Takeda, So-Ichiro Fukada, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Yoichi Nozato, Taku Fujimoto, Yuki Imaizumi, Serina Yokoyama, Motonori Nagasawa, Go Hamano, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki-Yamamoto, Shuko Takeda, Toshimasa Takahashi, Hiroshi Akasaka, Norihisa Itoh, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Hironori Nakagami, Hiromi Rakugi

Journal of cachexia, sarcopenia and muscle　Vol. 9　No. 5　p. 975-986　2018/10　Research paper (scientific journal)

プロレニンを標的とした治療ワクチンの2型糖尿病モデルでの基礎的検討

横田 陽匡, 林 宏樹, 長岡 泰司, 吉田 晃敏, 中神 啓徳

日本眼科学会雑誌　Vol. 122　No. 臨増　p. 237-237　2018/03

Pathophysiology of cardiovascular disease in diabetes mellitus.

Gerardo Rodriguez-Araujo, Hironori Nakagami

Cardiovascular endocrinology & metabolism　Vol. 7　No. 1　p. 4-9　2018/03　Research paper (scientific journal)

Development of a novel and feasible antibody therapy targeting vasohibin-2

EunSeo Lee, Yasuhiro Suzuki, Hironori Nakagami, Hideki Tomioka, Yasufumi Sato

CANCER SCIENCE　Vol. 109　p. 286-286　2018/01

Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice.

Shimamura M, Nakagami H, Shimizu H, Wakayama K, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Mochizuki H, Morishita R

BioMed research international　Vol. 2018　p. 4637084-4637084　2018　Research paper (scientific journal)

Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice.

Ryo Kawakami, Yoichi Nozato, Hironori Nakagami, Yuka Ikeda, Munehisa Shimamura, Shota Yoshida, Jiao Sun, Tomohiro Kawano, Yoichi Takami, Takahisa Noma, Hiromi Rakugi, Tetsuo Minamino, Ryuichi Morishita

PloS one　Vol. 13　No. 2　2018　Research paper (scientific journal)

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial.

Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Taku Fujimoto, Toshifumi Yamaoka, Misa Hayashi, Eiji Kiyohara, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Masaya Koshizaka, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Ichiro Katayama, Koutaro Yokote, Hiromi Rakugi

NPJ aging and mechanisms of disease　Vol. 4　p. 2-2　2018　Research paper (scientific journal)

Association between renin-angiotensin-aldosterone system blockade and future osteoporotic fracture risk in hypertensive population A population-based cohort study in Taiwan

Chang-I. Chen, Jong-Shiuan Yeh, Nai-Wen Tsao, Fen-Yen Lin, Chun-Ming Shih, Kuang-Hsing Chiang, Yung-Ta Kao, Yu-Ann Fang, Lung-Wen Tsai, Wen-Chi Liu, Hironori Nakagami, Ryuichi Morishita, Yi-Jie Kuo, Chun-Yao Huang

MEDICINE　Vol. 96　No. 46　2017/11　Research paper (scientific journal)

Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers

Hironori Nakagami, Toshifumi Yamaoka, Misa Hayashi, Atsushi Tanemura, Yasushi Takeya, Hitomi Kurinami, Ken Sugimoto, Ayumi Nakamura, Kazunori Tomono, Katsuto Tamai, Ichiro Katayama, Hiromi Rakugi, Yasufumi Kaneda

GERIATRICS & GERONTOLOGY INTERNATIONAL　Vol. 17　No. 11　p. 2150-2156　2017/11　Research paper (scientific journal)

糖尿病の新規バイオマーカーとしてのGFAPの解析(Glial Fibrillary Acidic Protein(GFAP) is a Novel Biomarker for Autoimmune Diabetes)

中神 啓徳, 楽木 宏実, 鷹見 洋一, 森下 竜一

日本高血圧学会総会プログラム・抄録集　Vol. 40回　p. 365-365　2017/10

Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes

Zhengda Pang, Akifumi Kushiyama, Jiao Sun, Takako Kikuchi, Hiroki Yamazaki, Yasuhiko Iwamoto, Hiroshi Koriyama, Shota Yoshida, Munehisa Shimamura, Masayoshi Higuchi, Tomohiro Kawano, Yoichi Takami, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

FASEB JOURNAL　Vol. 31　No. 9　p. 4053-4063　2017/09　Research paper (scientific journal)

Design of therapeutic vaccines as a novel antibody therapy for cardiovascular diseases

Hironori Nakagami

JOURNAL OF CARDIOLOGY　Vol. 70　No. 3-4　p. 201-205　2017/09　Research paper (scientific journal)

Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress

Kouji Wakayama, Munehisa Shimamura, Jun-ichi Suzuki, Ryo Watanabe, Hiroshi Koriyama, Hiroshi Akazawa, Hironori Nakagami, Hideki Mochizuki, Mitsuaki Isobe, Ryuichi Morishita

STROKE　Vol. 48　No. 5　p. 1362-+　2017/05　Research paper (scientific journal)

Fundamental study on gene transfer utilizing magnetic force and jet injector

T. Hasegawa, H. Nakagami, Y. Akiyama, S. Nishijima

Progress in Superconductivity and Cryogenics (PSAC)　Vol. 19　No. 1　p. 9-12　2017/03　Research paper (scientific journal)

A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

Ryo Watanabe, Jun-ichi Suzuki, Kouji Wakayama, Yasuhiro Maejima, Munehisa Shimamura, Hiroshi Koriyama, Hironori Nakagami, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Ryuichi Morishita, Issei Komuro, Mitsuaki Isobe

SCIENTIFIC REPORTS　Vol. 7　p. 43920-43920　2017/03　Research paper (scientific journal)

New treatment

Munehisa Shimamura, Hironori Nakagami, Kouji Wakayama, Tomohiro Kawano, Hideki Mochizuki, Ryuichi Morishita

STROKE　Vol. 48　2017/02

A novel lipoprotein (A) lowering drug, D-47, decreases neointima thickening after vascular injury

Yutaka Nakaya, Daiju Fukuda, Takashi Oyamada, Kazuo Ogawa, Nagakatsu Harada, Hironori Nakagami, Ryuichi Morishita, Masataka Sata, Hiroshi Sakaue

Journal of Medical Investigation　Vol. 64　No. 1-2　p. 64-67　2017　Research paper (scientific journal)

Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice

Zhengda Pang, Masayoshi Higuchi, Hiroshi Koriyama, Shota Yoshida, Hitomi Kurinami, Munehisa Shimamura, Yoichi Takami, Hiromi Rakugi, Ryuichi Morishita, Hironori Nakagami

FEBS LETTERS　Vol. 591　No. 1　p. 129-136　2017/01　Research paper (scientific journal)

A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke

Hitomi Kurinami, Munehisa Shimamura, Hironori Nakagami, Hideo Shimizu, Hiroshi Koriyama, Tomohiro Kawano, Kouji Wakayama, Hideki Mochizuki, Hiromi Rakugi, Ryuichi Morishita

SCIENTIFIC REPORTS　Vol. 6　p. 38062-38062　2016/11　Research paper (scientific journal)

DEVELOP A THERAPEUTIC VACCINE FOR ANGIOTENSIN II

Hironori Nakagami, Hiroshi Koriyama, Tomohiro Katsuya, Hiromi Rakugi, Ryuichi Morishita

JOURNAL OF HYPERTENSION　Vol. 34　p. E222-E222　2016/09

NOVEL THERAPEUTIC APPROACH FOR CEREBRAL ISCHEMIA IN RATS WITH ANGIOTENSIN II PEPTIDE VACCINE

Hironori Nakagami, Kouji Wakayama, Munehisa Shimamura, Jun-ichi Suzuki, Ryo Watanabe, Hiroshi Koriyama, Mitsuaki Isobe, Hiromi Rakugi, Ryuichi Morishita

JOURNAL OF HYPERTENSION　Vol. 34　p. E408-E408　2016/09

RANKL system in vascular and valve calcification with aging.

Ryo Kawakami, Hironori Nakagami, Takahisa Noma, Koji Ohmori, Masakazu Kohno, Ryuichi Morishita

Inflammation and regeneration　Vol. 36　p. 10-10　2016　Research paper (scientific journal)

加齢に伴う動脈硬化形成過程における脱ユビキチン化酵素CYLD(cylindromatosis)のマクロファージの泡沫化への影響

今泉 友希, 鷹見 洋一, 中神 啓徳, 山本 浩一, 樂木 宏実

日本内分泌学会雑誌　Vol. 91　No. 2　p. 637-637　2015/09

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor

Koichi Yamamoto, Akemi Kakino, Hikari Takeshita, Norihiro Hayashi, Lei Li, Atsushi Nakano, Hiroko Hanasaki-Yamamoto, Yoshiko Fujita, Yuki Imaizumi, Serina Toyama-Yokoyama, Chikako Nakama, Tatsuo Kawai, Masao Takeda, Kazuhiro Hongyo, Ryosuke Oguro, Yoshihiro Maekawa, Norihisa Itoh, Yoichi Takami, Miyuki Onishi, Yasushi Takeya, Ken Sugimoto, Kei Kamide, Hironori Nakagami, Mitsuru Ohishi, Theodore W. Kurtz, Tatsuya Sawamura, Hiromi Rakugi

FASEB JOURNAL　Vol. 29　No. 8　p. 3342-3356　2015/08　Research paper (scientific journal)

Effect of angiotensinII receptor blocker, olmesartan, on turnover of bone metabolism in bedridden elderly hypertensive women with disuse syndrome

Motokuni Aoki, Hirohisa Kawahata, Daisuke Sotobayashi, Hisahiro Yu, Atsushi Moriguchi, Hironori Nakagami, Toshio Ogihara, Ryuichi Morishita

GERIATRICS & GERONTOLOGY INTERNATIONAL　Vol. 15　No. 8　p. 1064-1072　2015/08　Research paper (scientific journal)

From discovery of novel antimicrobial peptide to clinical trial for drug development in wound repair

Hironori Nakagami

JOURNAL OF PHARMACOLOGICAL SCIENCES　Vol. 128　No. 3　p. S114-S114　2015/07

Low alpha-synuclein levels in the blood are associated with insulin resistance

Gerardo Rodriguez-Araujo, Hironori Nakagami, Yoichi Takami, Tomohiro Katsuya, Hiroshi Akasaka, Shigeyuki Saitoh, Kazuaki Shimamoto, Ryuichi Morishita, Hiromi Rakugi, Yasufumi Kaneda

SCIENTIFIC REPORTS　Vol. 5　p. 12081-12081　2015/07　Research paper (scientific journal)

Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats

Hiroshi Koriyama, Hironori Nakagami, Futoshi Nakagami, Mariana Kiomy Osako, Mariko Kyutoku, Munehisa Shimamura, Hitomi Kurinami, Tomohiro Katsuya, Hiromi Rakugi, Ryuichi Morishita

HYPERTENSION　Vol. 66　No. 1　p. 167-174　2015/07　Research paper (scientific journal)

Disease-associated polymorphisms in 9p21 are not associated with extreme longevity.

Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H

Geriatrics & gerontology international　Vol. 15　No. 6　p. 797-803　2015/06　Research paper (scientific journal)

Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse

Hirohisa Kawahata, Daisuke Sotobayashi, Motokuni Aoki, Hideo Shimizu, Hironori Nakagami, Toshio Ogihara, Ryuichi Morishita

HYPERTENSION RESEARCH　Vol. 38　No. 6　p. 382-393　2015/06　Research paper (scientific journal)

The Biphasic Effects of Oxidized-Low Density Lipoprotein on the Vasculogenic Function of Endothelial Progenitor Cells

Feng-Yen Lin, Nai-Wen Tsao, Chun-Ming Shih, Yi-Wen Lin, Jong-Shiua Yeh, Jaw-Wen Chen, Hironori Nakagami, Ryuichi Morishita, Tatsuya Sawamura, Chun-Yao Huang

PLOS ONE　Vol. 10　No. 5　2015/05　Research paper (scientific journal)

Evaluation of the Genetic Risk of Hypertension-Related Diseases

Hironori Nakagami

CIRCULATION JOURNAL　Vol. 79　No. 4　p. 756-757　2015/04

Development of DNA vaccines as an anti-hypertensive therapy or for anti-angiogenesis

Hironori Nakagami, Ryuichi Morishita

EXPERT OPINION ON BIOLOGICAL THERAPY　Vol. 15　No. 3　p. 431-436　2015/03　Research paper (scientific journal)

Teneligliptin: expectations for its pleiotropic action

Ryuichi Morishita, Hironori Nakagami

EXPERT OPINION ON PHARMACOTHERAPY　Vol. 16　No. 3　p. 417-426　2015/02　Research paper (scientific journal)

Molecular mechanism of vascular calcification with aging

NAKAGAMI Hironori

Blood & Vessel　Vol. 26　No. 3　p. 284-289　2015

Prevention of Neointimal Formation After Angioplasty Using Nuclear Factor-kappa B Decoy Oligodeoxynucleotide-Coated Balloon Catheter in Rabbit Model

Takashi Miyake, Shinya Ihara, Tetsuo Miyake, Yusuke Tsukada, Hajime Watanabe, Hiroaki Matsuda, Hideki Kiguchi, Hiroyuki Tsujimoto, Hironori Nakagami, Ryuichi Morishita

CIRCULATION-CARDIOVASCULAR INTERVENTIONS　Vol. 7　No. 6　p. 787-796　2014/12　Research paper (scientific journal)

Peptide vaccines for hypertension and diabetes mellitus

Hironori Nakagami, Hiroshi Koriyama, Ryuichi Morishita

Vaccines　Vol. 2　No. 4　p. 832-840　2014/11/26　Research paper (scientific journal)

Gene therapy for peripheral arterial disease

Munehisa Shimamura, Hironori Nakagami, Yoshiaki Taniyama, Ryuichi Morishita

EXPERT OPINION ON BIOLOGICAL THERAPY　Vol. 14　No. 8　p. 1175-1184　2014/08　Research paper (scientific journal)

[Bone metabolism and cardiovascular function update. Cross link of hypertension, bone loss and vascular calcification - common back grounds in renin angiotensin system with anti-aging aspect -].

Shimizu H, Nakagami H, Morishita R, Clinical calcium

Clinical calcium　Vol. 24　No. 7　p. 53-62　2014/07　Research paper (scientific journal)

The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome

Hironori Nakagami, Zhengda Pang, Takashi Shimosato, Toshinori Moritani, Hitomi Kurinami, Hiroshi Koriyama, Akiko Tenma, Munehisa Shimamura, Ryuichi Morishita

HYPERTENSION RESEARCH　Vol. 37　No. 7　p. 629-635　2014/07　Research paper (scientific journal)

禿頭自然発症ラットをもちいた禿頭遺伝子解析へのアプローチ

志水 秀郎, 中神 啓徳, 山田 秀和, 勝谷 友宏, 森下 竜一

日本抗加齢医学会総会プログラム・抄録集　Vol. 14回　p. 348-348　2014/06

OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice

Munehisa Shimamura, Hironori Nakagami, Mariana K. Osako, Hitomi Kurinami, Hiroshi Koriyama, Pang Zhengda, Hideki Tomioka, Akiko Tenma, Kouji Wakayama, Ryuichi Morishita

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 22　p. 8191-8196　2014/06　Research paper (scientific journal)

Long-term expression of periostin during the chronic stage of ischemic stroke in mice

Munehisa Shimamura, Yoshiaki Taniyama, Hironori Nakagami, Naruto Katsuragi, Kouji Wakayama, Hiroshi Koriyama, Hitomi Kurinami, Akiko Tenma, Hideki Tomioka, Ryuichi Morishita

HYPERTENSION RESEARCH　Vol. 37　No. 6　p. 494-499　2014/06　Research paper (scientific journal)

Therapeutic vaccine against DPP4 improves glucose metabolism in mice

Zhengda Pang, Hironori Nakagami, Mariana K. Osako, Hiroshi Koriyama, Futoshi Nakagami, Hideki Tomioka, Munehisa Shimamura, Hitomi Kurinami, Yoichi Takami, Ryuichi Morishita, Hiromi Rakugi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 111　No. 13　p. E1256-E1263　2014/04　Research paper (scientific journal)

Therapeutic Vaccines for Hypertension and Dyslipidemia

Hironori Nakagami, Hiroshi Koriyama, Ryuichi Morishita

INTERNATIONAL HEART JOURNAL　Vol. 55　No. 2　p. 96-100　2014/03　Research paper (scientific journal)

Novel Anti-Microbial Peptide SR-0379 Accelerates Wound Healing via the PI3 Kinase/Akt/mTOR Pathway

Hideki Tomioka, Hironori Nakagami, Akiko Tenma, Yoshimi Saito, Toshihiro Kaga, Toshihide Kanamori, Nao Tamura, Kazunori Tomono, Yasufumi Kaneda, Ryuichi Morishita

PLOS ONE　Vol. 9　No. 3　2014/03　Research paper (scientific journal)

Development of LC-MS/MS quantification of the novel antimicrobial peptide, SR-0379, and its pharmacokinetics in rats

Hideki Tomioka, Hironori Nakagami, Tomokazu Sano, Kazuaki Takafuji, Seiji Takashima, Yasufumi Kaneda, Ryuichi Morishita

Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 14　No. 1　p. 26-31　2014　Research paper (scientific journal)

糖代謝におけるレニン・アンジオテンシン系の役割

志水 秀郎, 中神 啓徳, 森下 竜一

Anti-aging Science　Vol. 5　No. 3　p. 231-231　2013/12

GEANE study group; HOMED-BP study group. Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study.

Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y, Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y

Pharmacogenomics　Vol. 14　No. 14　p. 1709-1721　2013/11　Research paper (scientific journal)

Development of novel DNA vaccine for VEGF in murine cancer model

Mariko Kyutoku, Hironori Nakagami, Hiroshi Koriyama, Hideki Tomioka, Futoshi Nakagami, Munehisa Shimamura, Hitomi Kurinami, Pang Zhengda, Dong Hyun Jo, Jeong Hun Kim, Nobuyuki Takakura, Ryuichi Morishita

SCIENTIFIC REPORTS　Vol. 3　2013/11　Research paper (scientific journal)

マウスのDPP4に対する治療用ワクチンの有効性と安全性(Effectiveness and safety of a therapeutic vaccine against DPP4 in mice)

Pang Zhengda, 中神 啓徳, Osako Mariana Kiomy, 郡山 弘, 鷹見 洋一, 樂木 宏実

日本内分泌学会雑誌　Vol. 89　No. 2　p. 756-756　2013/09

Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model

Munehisa Shimamura, Hironori Nakagami, Masataka Sata, Minoru Takaoka, Junya Azuma, Mariana Kiomy Osako, Hiroshi Koriyama, Hitomi Kurinami, Kouji Wakayama, Takashi Miyake, Ryuichi Morishita

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　Vol. 33　No. 8　p. 1153-1159　2013/08　Research paper (scientific journal)

アクリジン・オレンジを用いた破骨細胞酸産生能評価による各種降圧剤のスクリーニング

志水 秀郎, 中神 啓徳, 尾崎 和成, 楠 博, 森下 竜一

日本抗加齢医学会総会プログラム・抄録集　Vol. 13回　p. 239-239　2013/06

Do Angiotensin Receptor Blockers Protect Against Alzheimer's Disease?

Hitomi Kurinami, Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Ryuichi Morishita

DRUGS & AGING　Vol. 30　No. 6　p. 367-372　2013/06　Research paper (scientific journal)

Cross-Talk of Receptor Activator of Nuclear Factor-kappa B Ligand Signaling With Renin-Angiotensin System in Vascular Calcification

Mariana Kiomy Osako, Hironori Nakagami, Munehisa Shimamura, Hiroshi Koriyama, Futoshi Nakagami, Hideo Shimizu, Takashi Miyake, Masao Yoshizumi, Hiromi Rakugi, Ryuichi Morishita

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 33　No. 6　p. 1287-+　2013/06　Research paper (scientific journal)

Potential Effect of Angiotensin II Receptor Blockade in Adipose Tissue and Bone

Hironori Nakagami, Mariana Kiomy Osako, Ryuichi Morishita

CURRENT PHARMACEUTICAL DESIGN　Vol. 19　No. 17　p. 3049-3053　2013/05　Research paper (scientific journal)

Inhibition of Neointima Formation through DNA Vaccination for Apolipoprotein(a): A New Therapeutic Strategy for Lipoprotein(a)

Mariko Kyutoku, Hironori Nakagami, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hitomi Kurinami, Hideki Tomioka, Takashi Miyake, Tomohiro Katsuya, Ryuichi Morishita

SCIENTIFIC REPORTS　Vol. 3　2013/04　Research paper (scientific journal)

[Hypertension and osteoporosis].

Nakagami H, Morishita R, Clinical calcium

Vol. 23　No. 4　p. 497-503　2013/04

The mechanism of white and brown adipocyte differentiation

Hironori Nakagami

Diabetes and Metabolism Journal　Vol. 37　No. 2　p. 85-90　2013/04

Human gene therapy in cardiovascular diseases

Mariana Kiomy Osako, Hironori Nakagami, Ryuichi Morishita

Gene Therapy: Technologies and Applications　p. 85-93　2013/03/01　Part of collection (book)

Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice

Futoshi Nakagami, Hiroshi Koriyama, Hironori Nakagami, Mariana Kiomy Osako, Munehisa Shimamura, Mariko Kyutoku, Takashi Miyake, Tomohiro Katsuya, Hiromi Rakugi, Ryuichi Morishita

PLOS ONE　Vol. 8　No. 3　2013/03　Research paper (scientific journal)

Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway

Gerardo Rodriguez-Araujo, Hironori Nakagami, Hiroki Hayashi, Masaki Mori, Tetsuya Shiuchi, Yasuhiko Minokoshi, Yoshikazu Nakaoka, Yoichi Takami, Issei Komuro, Ryuichi Morishita, Yasufumi Kaneda

Cellular and Molecular Life Sciences　Vol. 70　No. 6　p. 1123-1133　2013/03　Research paper (scientific journal)

The Transcription Factors Tbx18 and Wt1 Control the Epicardial Epithelial-Mesenchymal Transition through Bi-Directional Regulation of Slug in Murine Primary Epicardial Cells

Makiko Takeichi, Keisuke Nimura, Masaki Mori, Hironori Nakagami, Yasufumi Kaneda

PLOS ONE　Vol. 8　No. 2　2013/02　Research paper (scientific journal)

Olmesartan reduces pentosidine production and ameliorates fragility of bone in ovariectomized fructose-fed rats

Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Osako Kiomy Mariana, Ryuichi Morishita

Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 13　No. 2　p. 150-158　2013　Research paper (scientific journal)

Lymphedema and Therapeutic Lymphangiogenesis

Yukihiro Saito, Hironori Nakagami, Yasufumi Kaneda, Ryuichi Morishita

BIOMED RESEARCH INTERNATIONAL　Vol. 2013　2013

Gene Therapy and Cell-Based Therapies for Therapeutic Angiogenesis in Peripheral Artery Disease

Munehisa Shimamura, Hironori Nakagami, Hiroshi Koriyama, Ryuichi Morishita

BIOMED RESEARCH INTERNATIONAL　Vol. 2013　2013

Therapeutic Effect of Ribbon-Type Nuclear Factor-kappa B Decoy Oligonucleotides in a Rat Model of Inflammatory Bowel Disease

Kazunari Ozaki, Hirofumi Makino, Motokuni Aoki, Takashi Miyake, Natsuki Yasumasa, Mariana Kiomy Osako, Hironori Nakagami, Hiromi Rakugi, Ryuichi Morishita

CURRENT GENE THERAPY　Vol. 12　No. 6　p. 484-492　2012/12

Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells

Chun-Yao Huang, Chun-Ming Shih, Nai-Wen Tsao, Yi-Wen Lin, Po-Hsun Huang, Shinn-Chih Wu, Ai-Wei Lee, Yung-Ta Kao, Nen-Chung Chang, Hironori Nakagami, Ryuichi Morishita, Keng-Liang Ou, Wen-Chi Hou, Cheng-Yen Lin, Kuo-Gi Shyu, Feng-Yen Lin

BRITISH JOURNAL OF PHARMACOLOGY　Vol. 167　No. 7　p. 1506-1519　2012/12　Research paper (scientific journal)

Moderate to High Concentrations of High-Density Lipoprotein From Healthy Subjects Paradoxically Impair Human Endothelial Progenitor Cells and Related Angiogenesis by Activating Rho-Associated Kinase Pathways

Chun-Yao Huang, Feng-Yen Lin, Chun-Ming Shih, Heng-Kien Au, Yu-Jia Chang, Hironori Nakagami, Ryuichi Morishita, Nen-Chung Chang, Kou-Gi Shyu, Jaw-Wen Chen

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 32　No. 10　p. 2405-2417　2012/10　Research paper (scientific journal)

[Activation of osteoclasts by RAAS and strategy of target therapy on bone metabolic diseases].

Shimizu H, Nakagami H, Morishita R, Nihon rinsho, Japanese journal of clinical medicine

Vol. 70　No. 9　p. 1524-1529　2012/09

Nucleic Acid Drugs for Preventing Restenosis after Coronary Revascularization

Takashi Miyake, Hironori Nakagami, Ryuichi Morishita

CURRENT TOPICS IN MEDICINAL CHEMISTRY　Vol. 12　No. 15　p. 1613-1620　2012/08

Modification of Decoy Oligodeoxynucleotides to Achieve the Stability and Therapeutic Efficacy

Mariana Kiomy Osako, Hironori Nakagami, Ryuichi Morishita

CURRENT TOPICS IN MEDICINAL CHEMISTRY　Vol. 12　No. 15　p. 1603-1607　2012/08

Development of Nucleic Acid Drugs for Neurological Disorders

Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Yoshiaki Taniyama, Ryuichi Morishita

CURRENT TOPICS IN MEDICINAL CHEMISTRY　Vol. 12　No. 15　p. 1621-1629　2012/08

Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents

Hironori Nakagami, Tomoyuki Nishikawa, Nao Tamura, Akito Maeda, Hajime Hibino, Masayoshi Mochizuki, Takashi Shimosato, Toshinori Moriya, Ryuichi Morishita, Katsuto Tamai, Kazunori Tomono, Yasufumi Kaneda

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE　Vol. 16　No. 7　p. 1629-1639　2012/07　Research paper (scientific journal)

HIG1, a novel regulator of mitochondrial gamma-secretase, maintains normal mitochondrial function

Hiroki Hayashi, Hironori Nakagami, Makiko Takeichi, Munehisa Shimamura, Nobutaka Koibuchi, Eiji Oiki, Naoyuki Sato, Hiroshi Koriyama, Masaki Mori, Rodriguez Gerardo Araujo, Akito Maeda, Ryuichi Morishita, Katsuto Tamai, Yasufumi Kaneda

FASEB JOURNAL　Vol. 26　No. 6　p. 2306-2317　2012/06　Research paper (scientific journal)

パーキンソン病関連分子αシヌクレインの老化関連疾患における新規機能 メタボリック症候群及び血管内皮機能への関与

鷹見 洋一, 大石 充, 中神 啓徳, 神出 計, 山本 浩一, 金田 安史, 楽木 宏実

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　Vol. 1回　p. 139-139　2012/04

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

Masaki Mori, Hironori Nakagami, Gerardo Rodriguez-Araujo, Keisuke Nimura, Yasufumi Kaneda

PLOS BIOLOGY　Vol. 10　No. 4　2012/04　Research paper (scientific journal)

Role of Central Nervous System Periostin in Cerebral Ischemia

Munehisa Shimamura, Yoshiaki Taniyama, Naruto Katsuragi, Nobutaka Koibuchi, Mariko Kyutoku, Naoyuki Sato, Mohammad Allahtavakoli, Kouji Wakayama, Hironori Nakagami, Ryuichi Morishita

STROKE　Vol. 43　No. 4　p. 1108-U341　2012/04　Research paper (scientific journal)

Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application

Mariana Kiomy Osako, Hironori Nakagami, Ryuichi Morishita

NUCLEIC ACID DRUGS　Vol. 249　p. 49-59　2012　Part of collection (book)

Links Between Hypertension and Osteoporosis: Benidipine Ameliorates Osteoporosis in Ovariectomized Hypertensive Rats Through Promotion of Osteoblast Proliferation and Inhibition of Osteoclast Differentiation

Shimizu H, Nakagami H, Yasumasa N, Mariana O.K, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R

Current Cardiovascular Risk Reports　Vol. 6　No. 4　p. 274-280　2012　Research paper (scientific journal)

Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet

Hironori Nakagami, Munehisa Shimamura, Takashi Miyake, Takashi Shimosato, Noriko Minobe, Toshinori Moritani, Mariana Kiomy Osako, Futoshi Nakagami, Hiroshi Koriyama, Mariko Kyutoku, Hideo Shimizu, Tomohiro Katsuya, Ryuichi Morishita

MOLECULAR MEDICINE REPORTS　Vol. 5　No. 1　p. 37-40　2012/01　Research paper (scientific journal)

Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel

Hideo Shimizu, Hironori Nakagami, Natsuki Yasumasa, Osako Kiomy Mariana, Mariko Kyutoku, Hiroshi Koriyama, Futoshi Nakagami, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

HYPERTENSION RESEARCH　Vol. 35　No. 1　p. 77-81　2012/01　Research paper (scientific journal)

Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.

Popov S, Silveira A, Wågsäter D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, Metoki H, Kikuya M, Ohkubo T, Katsuya T, Rakugi H, Imai Y, Sanchez F, Leosdottir M, Syvänen AC, Hamsten A, Melander O, Bertorello AM

Journal of hypertension　Vol. 29　No. 12　p. 2395-2403　2011/12

Critical Roles of Cold Shock Domain Protein A as an Endogenous Angiogenesis Inhibitor in Skeletal Muscle

Yukihiro Saito, Hironori Nakagami, Nobuyoshi Azuma, Satoshi Hirata, Fumihiro Sanada, Yoshiaki Taniyama, Ryuichi Morishita, Yasufumi Kaneda, Tadahiro Sasajima

ANTIOXIDANTS & REDOX SIGNALING　Vol. 15　No. 8　p. 2109-2120　2011/10　Research paper (scientific journal)

Irbesartan improves endothelial dysfunction, abnormal lipid profile, proteinuria and liver dysfunction in Zucker diabetic fatty rats independent of glucose and insulin levels

Munehisa Shimamura, Hironori Nakagami, Takashi Shimosato, Toshinori Moritani, Futoshi Nakagami, Mariana Kiomy Osako, Takashi Miyake, Hiroshi Koriyama, Hideo Shimizu, Ryuichi Morishita

EXPERIMENTAL AND THERAPEUTIC MEDICINE　Vol. 2　No. 5　p. 957-961　2011/09　Research paper (scientific journal)

Can Forkhead Box P1 be a novel therapeutic target for atherosclerosis?

Hironori Nakagami, Ryuichi Morishita

ATHEROSCLEROSIS　Vol. 218　No. 1　p. 26-27　2011/09

[The cutting-edge of medicine; anti-aging and cardiovascular diseases].

Nakagami H, Morishita R, Nihon Naika, Gakkai, zasshi. The Journal of, the, Japanese, Society of Internal, Medicine

Nihon Naika Gakkai Kaishi　Vol. 100　No. 6　p. 1677-1682　2011/06

[Hypertension, CKD and bone metabolism].

Nakagami H, Morishita R, Clinical calcium

Vol. 21　No. 5　p. 685-689　2011/05

低用量の利尿剤とARB併用によるRAS活性の抑制と骨代謝改善効果

志水 秀郎, 安政 奈都記, 島村 宗尚, 楠 博, 中神 啓徳, 森下 竜一

日本抗加齢医学会総会プログラム・抄録集　Vol. 11回　p. 317-317　2011/04

Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study.

Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y

Hypertension research : official journal of the Japanese Society of Hypertension　Vol. 34　No. 4　p. 530-535　2011/04

Obesity and Gastrointestinal Hormones-Dual Effect of Angiotensin II Receptor Blockade and a Partial Agonist of PPAR-gamma

Hironori Nakagami, Ryuichi Morishita

CURRENT VASCULAR PHARMACOLOGY　Vol. 9　No. 2　p. 162-166　2011/03　Research paper (scientific journal)

Unexpected link between hypertension and osteoporosis

Hideo Shimizu, Hironori Nakagami, Yasushi Takeya, Hiromi Rakugi, Ryuichi Morishita

Hypertension and Bone Loss　p. 66-88　2011　Part of collection (book)

[Common molecular mechanism of osteoporosis and vascular diseases].

Hironori Nakagami, Mariana Kiomy Osako, Hideo Shimizu, Hiromi Rakugi, Ryuichi Morishita

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics　Vol. 48　No. 2　p. 146-8　2011

Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor kappa B and Ets Prevents Abdominal Aortic Aneurysm in Rat Model

Takashi Miyake, Motokuni Aoki, Mariana K. Osako, Munehisa Shimamura, Hironori Nakagami, Ryuichi Morishita

MOLECULAR THERAPY　Vol. 19　No. 1　p. 181-187　2011/01　Research paper (scientific journal)

New Concept of Vascular Calcification and Metabolism

Hironori Nakagami, Mariana K. Osako, Ryuichi Morishita

CURRENT VASCULAR PHARMACOLOGY　Vol. 9　No. 1　p. 124-127　2011/01　Research paper (scientific journal)

Cold shock domain protein A (CSDA) overexpression inhibits tumor growth and lymph node metastasis in a mouse model of squamous cell carcinoma

Goichi Matsumoto, Nobuyuki Yajima, Hiroyuki Saito, Hironori Nakagami, Yasushi Omi, Ushaku Lee, Yasufumi Kaneda

CLINICAL & EXPERIMENTAL METASTASIS　Vol. 27　No. 7　p. 539-547　2010/10　Research paper (scientific journal)

Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan

Hironori Nakagami, Mariana Kiomy Osako, Futoshi Nakagami, Takashi Shimosato, Noriko Minobe, Toshinori Moritani, Munehisa Shimamura, Takashi Miyake, Hideo Shimizu, Yasushi Takeya, Ryuichi Morishita

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 26　No. 4　p. 477-481　2010/10　Research paper (scientific journal)

Estrogen Inhibits Vascular Calcification via Vascular RANKL System Common Mechanism of Osteoporosis and Vascular Calcification

Mariana Kiomy Osako, Hironori Nakagami, Nobutaka Koibuchi, Hideo Shimizu, Futoshi Nakagami, Hiroshi Koriyama, Munehisa Shimamura, Takashi Miyake, Hiromi Rakugi, Ryuichi Morishita

CIRCULATION RESEARCH　Vol. 107　No. 4　p. 466-U57　2010/08　Research paper (scientific journal)

Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells

Daiki Morimoto, Tetsuya Tomita, Shoko Kuroda, Chikahisa Higuchi, Shinichi Kato, Toshikazu Shiba, Hironori Nakagami, Ryuichi Morishita, Hideki Yoshikawa

JOURNAL OF BONE AND MINERAL METABOLISM　Vol. 28　No. 4　p. 418-423　2010/07　Research paper (scientific journal)

Estrogen attenuates vascular remodeling in Lp(a) transgenic mice

Futoshi Nakagami, Hironori Nakagami, Mariana Kiomy Osako, Masaaki Iwabayashi, Yoshiaki Taniyama, Takefumi Doi, Hideo Shimizu, Munehisa Shimamura, Hiromi Rakugi, Ryuichi Morishita

ATHEROSCLEROSIS　Vol. 211　No. 1　p. 41-47　2010/07　Research paper (scientific journal)

Variation in OSBPL10 is associated with dyslipidemia

Hiroshi Koriyama, Hironori Nakagami, Tomohiro Katsuya, Hiroshi Akasaka, Shigeyuki Saitoh, Kazuaki Shimamoto, Toshio Ogihara, Yasufumi Kaneda, Ryuichi Morishita, Hiromi Rakugi

HYPERTENSION RESEARCH　Vol. 33　No. 5　p. 511-514　2010/05　Research paper (scientific journal)

Effect of an Antimicrobial Agent on Atherosclerotic Plaques Assessment of Metalloproteinase Activity by Molecular Imaging

Satoru Ohshima, Shinichiro Fujimoto, Artiom Petrov, Hironori Nakagami, Nezam Haider, Jun Zhou, Nobuhiro Tahara, Mariana Kiomy Osako, Ai Fujimoto, Jie Zhu, Toyoaki Murohara, D. Scott Edwards, Navneet Narula, Nathan D. Wong, Y. Chandrashekhar, Ryuichi Morishita, Jagat Narula

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　Vol. 55　No. 12　p. 1240-1249　2010/03　Research paper (scientific journal)

Accumulation of common polymorphisms is associated with development of hypertension:a 12-year follow-up from the Ohasama study.

Watanabe Y, Metoki H, Ohkubo T, Katsuya T, Tabara Y, Kikuya M, Hirose T, Sugimoto K, Asayama K, Inoue R, Hara A, Obara T, Nakura J, Kohara K, Totsune K, Ogihara T, Rakugi H, Miki T, Imai Y

Hypertension Research　Vol. 33　No. 2　p. 129-134　2010/02　Research paper (scientific journal)

Gene Therapy Toward Clinical Application in the Cardiovascular Field

Hironori Nakagami, Mariana Kiomy Osako, Ryuichi Morishita

Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging　2010/01/01　Part of collection (book)

Anti-Aging Medicine in Cardiovascular Disease

Morishita Ryuichi, Komuro Issei, Horiuchi Masatsugu, Nakagami Hironori, Minamino Toru, Higashi Yukihito

Anti-Aging Med　Vol. 7　No. 5　p. 45-49　2010　Research paper (scientific journal)

Identification of Evidence Suggestive of an Association with Peripheral Arterial Disease at the OSBPL10 Locus by Genome-Wide Investigation in the Japanese Population

Hiroshi Koriyama, Hironori Nakagami, Tomohiro Katsuya, Ken Sugimoto, Hidetoshi Yamashita, Yoichi Takami, Shiro Maeda, Michiaki Kubo, Atsushi Takahashi, Yusuke Nakamura, Toshio Ogihara, Hiromi Rakugi, Yasufumi Kaneda, Ryuichi Morishita

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　Vol. 17　No. 10　p. 1054-1062　2010　Research paper (scientific journal)

Priming With Angiopoietin-1 Augments the Vasculogenic Potential of the Peripheral Blood Stem Cells Mobilized With Granulocyte Colony-Stimulating Factor Through a Novel Tie2/Ets-1 Pathway

Min-Seok Kim, Choon-Soo Lee, Jin Hur, Hyun-Jai Cho, Soo-In Jun, Tae-Youn Kim, Sae-Won Lee, Jung-Won Suh, Kyung-Woo Park, Hae-Young Lee, Hyun-Jae Kang, Dong-Soo Lee, Gou-Young Koh, Hironori Nakagami, Ryuichi Morishita, Young-Bae Park, Hyo-Soo Kim

CIRCULATION　Vol. 120　No. 22　p. 2240-U150　2009/12　Research paper (scientific journal)

Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats

Hideo Shimizu, Hironori Nakagami, Mariana Kiomy Osako, Futoshi Nakagami, Yasuo Kunugiza, Tetsuya Tomita, Hideki Yoshikawa, Hiromi Rakugi, Toshio Ogihara, Ryuichi Morishita

HYPERTENSION RESEARCH　Vol. 32　No. 9　p. 786-790　2009/09　Research paper (scientific journal)

New Treatment of Periodontal Diseases by Using NF-kappa B Decoy Oligodeoxynucleotides via Prevention of Bone Resorption and Promotion of Wound Healing

Hideo Shimizu, Hironori Nakagami, Shosuke Morita, Ikuyo Tsukamoto, Mariana Kiomy Osako, Futoshi Nakagami, Takashi Shimosato, Noriko Minobe, Ryuichi Morishita

ANTIOXIDANTS & REDOX SIGNALING　Vol. 11　No. 9　p. 2065-2075　2009/09　Research paper (scientific journal)

[Hormones and osteoporosis update. Effect of angiotensin II on bone metabolism].

Nakagami H, Morishita R, Clinical calcium

Vol. 19　No. 7　p. 997-1002　2009/07

[Gene therapy for anti-aging medicine].

Nakagami H, Morishita R, Nihon rinsho, Japanese journal of clinical medicine

Vol. 67　No. 7　p. 1407-1411　2009/07

Zyxin Mediates Actin Fiber Reorganization in Epithelial-Mesenchymal Transition and Contributes to Endocardial Morphogenesis

Masaki Mori, Hironori Nakagami, Nobutaka Koibuchi, Koichi Miura, Yoichi Takami, Hiroshi Koriyama, Hiroki Hayashi, Hisataka Sabe, Naoki Mochizuki, Ryuichi Morishita, Yasufumi Kaneda

MOLECULAR BIOLOGY OF THE CELL　Vol. 20　No. 13　p. 3115-3124　2009/07　Research paper (scientific journal)

FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1

Hiroki Hayashi, Hironori Nakagami, Yoichi Takami, Hiroshi Koriyama, Masaki Mori, Katsuto Tamai, Jianxin Sun, Kaori Nagao, Ryuichi Morishita, Yasufumi Kaneda

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 29　No. 6　p. 909-U331　2009/06　Research paper (scientific journal)

Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action

Rie Hanayam, Hideo Shimizu, Hironori Nakagami, Mariana Kiomy Osako, Hirofumi Makino, Yasuo Kunugiza, Tetsuya Tomita, Ikuyo Tsukamoto, Hideki Yoshikawa, Hiromi Rakugi, Ryuchi Morishita

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 23　No. 5　p. 581-588　2009/05　Research paper (scientific journal)

Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men: the Ohasama study.

Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y

American journal of hypertension　Vol. 22　p. 294-299　2009/03

Vascular protective effects of ezetimibe in ApoE-deficient mice

Hironori Nakagami, Mariana Kiomy Osako, Yoichi Takami, Rie Hanayama, Hiroshi Koriyama, Masaki Mori, Hiroki Hayashi, Hideo Shimizu, Ryuichi Morishita

ATHEROSCLEROSIS　Vol. 203　No. 1　p. 51-58　2009/03　Research paper (scientific journal)

Development of a novel antimicrobial peptide, AG-30, with angiogenic properties

Tomoyuki Nishikawa, Hironori Nakagami, Akito Maeda, Ryuichi Morishita, Nobuhiko Miyazaki, Toshihiro Ogawa, Yasuhiko Tabata, Yasushi Kikuchi, Hiroki Hayashi, Yoshiro Tatsu, Noboru Yumoto, Katsuto Tamai, Kazunori Tomono, Yasufumi Kaneda

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE　Vol. 13　No. 3　p. 535-546　2009/03　Research paper (scientific journal)

PITAVASTATIN SUPPRESSES FORMATION AND PROGRESSION OF CEREBRAL ANEURYSMS THROUGH INHIBITION OF THE NUCLEAR FACTOR kappa B PATHWAY

Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Hironori Nakagami, Kazuhiko Nozaki, Ryuuichi Morishita, Nobuo Hashimoto

NEUROSURGERY　Vol. 64　No. 2　p. 357-365　2009/02　Research paper (scientific journal)

ゲノムワイド関連解析による閉塞性動脈硬化症感受性遺伝子座の同定

郡山 弘, 中神 啓徳, 勝谷 友宏, 杉本 研, 山下 英俊, 鷹見 洋一, 赤坂 憲, 斎藤 重幸, 前田 士朗, 中村 裕輔, 金田 安史, 樂木 宏実, 森下 竜一, 島本 和明, 荻原 俊男

日本高血圧学会総会プログラム・抄録集　Vol. 31回　p. 170-170　2008/10

テルミサルタンの抗動脈硬化作用の検討

中神 啓徳, 鷹見 洋一, 郡山 弘, 勝谷 友宏, 樂木 宏実, 森下 竜一

日本高血圧学会総会プログラム・抄録集　Vol. 31回　p. 175-175　2008/10

Cold shock domain protein A, novel endogenous regulator of angiogenesis in heart

Yukihiro Saito, Hironori Nakagami, Nobuyoshi Azuma, Ryuichi Morishita, Yasufumi Kaneda, Tadahiro Sasajima

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 45　No. 4　p. S7-S8　2008/10

Differential response of vascular hepatocyte growth factor concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice

Hironori Nakagami, Mariana Kiomy Osako, Yoichi Takami, Rie Hanayama, Hiroshi Koriyama, Masaki Mori, Hiroki Hayashi, Hideo Shimizu, Ryuichi Morishita

MOLECULAR MEDICINE REPORTS　Vol. 1　No. 5　p. 657-661　2008/09　Research paper (scientific journal)

Angiotensin II accelerates osteoporosis by activating osteoclasts

Hideo Shimizu, Hironori Nakagami, Mariana Kiomy Osako, Rie Hanayama, Yasuo Kunugiza, Takuji Kizawa, Tetsuya Tomita, Hideki Yoshikawa, Toshio Ogihara, Ryuichi Morishita

FASEB JOURNAL　Vol. 22　No. 7　p. 2465-2475　2008/07　Research paper (scientific journal)

Pleiotropic effect of statins as antioxidants on cardiac hypertrophy

Hironori Nakagami, Ryuichi Morishita

Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry　Vol. 8　No. 2　p. 167-171　2008/06　Research paper (scientific journal)

Identification of angiogenic and antimicrobial factor, AG-30, and analysis of its De Novo engineered variants

Tomoyuki Nishikawa, Hironori Nakagami, Akito Maeda, Nobuhiko Miyazaki, Yasuhiko Tabata, Ryuichi Morishita, Katsuto Tamai, Yasufumi Kaneda

JOURNAL OF GENE MEDICINE　Vol. 10　No. 4　p. 473-473　2008/04　Research paper (scientific journal)

Potential role of CYLD (cylindromatosis) as a deubiquitinating enzyme in vascular cells

Yoichi Takami, Hironori Nakagami, Ryuichi Morishita, Tomohiro Katsuya, Hiroki Hayashi, Masaki Mori, Hiroshi Koriyama, Yoshichika Baba, Osamu Yasuda, Hiromi Rakugi, Toshio Ogihara, Yasufumi Kaneda

AMERICAN JOURNAL OF PATHOLOGY　Vol. 172　No. 3　p. 818-829　2008/03　Research paper (scientific journal)

Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element

Y. Saito, H. Nakagami, M. Kurooka, Y. Takami, Y. Kikuchi, H. Hayashi, T. Nishikawa, K. Tamai, R. Morishita, N. Azuma, T. Sasajima, Y. Kaneda

ONCOGENE　Vol. 27　No. 13　p. 1821-1833　2008/03　Research paper (scientific journal)

Polymorphism of myospryn is associated with left ventricular diastolic dysfunction

Kikuchi Yasushi, Nakagami Hironori, Katsuya Tomohiro, Morishita Ryuichi, Horio Takeshi, Kamide Kei, Miyata Toshiyuki, Kawano Yuhei, Takami Yoichi, Rakugi Hiromi, Kaneda Yasufumi, Ogihara Toshio

Anti-Aging Med　Vol. 5　No. 4　p. 49-52　2008

Aging of Blood Vessels

Nakagami Hironori, Morishita Ryuichi

Anti-Aging Med　Vol. 5　No. 7　p. 73-77　2008

NFκB decoy oligodeoxynucleotide-based therapy in cardiovascular diseases

H. Nakagami, M. K. Osako, N. Tomita, R. Morishita

RNA Technologies in Cardiovascular Medicine and Research　p. 299-309　2008　Part of collection (book)

NF-kappa B is a key mediator of cerebral aneurysm formation

Tomohiro Aoki, Hiroharu Kataoka, Munehisa Shimamura, Hironori Nakagami, Kouji Wakayama, Takuya Moriwaki, Ryota Ishibashi, Kazuhiko Nozaki, Ryuichi Morishita, Nobuo Hashimoto

CIRCULATION　Vol. 116　No. 24　p. 2830-2840　2007/12　Research paper (scientific journal)

Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension

Hironori Nakagami, Yasushi Kikuchi, Tomohiro Katsuya, Ryuichi Morishita, Hiroshi Akasaka, Shigeyuki Saitoh, Hiromi Rakugi, Yasufumi Kaneda, Kazuaki Shimamoto, Toshio Ogihara

HYPERTENSION RESEARCH　Vol. 30　No. 12　p. 1239-1246　2007/12　Research paper (scientific journal)

Involvement of gamma-secretase in postnatal angiogenesis

Hiroki Hayashi, Hironori Nakagami, Yoichi Takami, Naoyuki Sato, Yukihiro Saito, Tomoyuki Nishikawa, Masaki Mori, Hiroshi Koriyama, Katsuto Tamai, Ryuichi Morishita, Yasufumi Kaneda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 363　No. 3　p. 584-590　2007/11　Research paper (scientific journal)

脱ユビキチン化酵素CYLD(cylindromatosis)の血管における機能

鷹見 洋一, 中神 啓徳, 森下 竜一, 勝谷 友宏, 楽木 宏実, 金田 安史, 荻原 俊男

日本高血圧学会総会プログラム・抄録集　Vol. 30回　p. 160-160　2007/10

Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappa B activation

Yoichi Takami, Hironori Nakagami, Ryuichi Morishita, Tomohiro Katsuya, Tai-Xing Cui, Tomonaga Ichikawa, Yukihiro Saito, Hiroki Hayashi, Yasushi Kikuchi, Tomoyuki Nishikawa, Yoshichika Baba, Osamu Yasuda, Hiromi Rakugi, Toshio Ogihara, Yasufumi Kaneda

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 27　No. 10　p. 2184-2190　2007/10　Research paper (scientific journal)

Recent progress in therapeutic angiogenesis.

Nakagami H, Morishita R, International journal of, biomedical science, IJBS, v

Vol. 3　No. 3　p. 153-158　2007/09

Increase in nuclease resistance and incorporation of NF-kappa B decoy oligodeoxynucteotides by modification of the 3 '-terminus

Mariana Kiomy Osako, Naruya Abstract Tomita, Hironori Nakagami, Yasuo Kunugiza, Masafumi Yoshino, Kazuhiko Yuyama, Tetsuya Tomita, Hideki Be Specific To The Target Transcription Fac, Toshio Ogihara, Ryuichi Morishita

JOURNAL OF GENE MEDICINE　Vol. 9　No. 9　p. 812-819　2007/09　Research paper (scientific journal)

Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis

Yukihiro Saito, Hironori Nakagami, Ryuichi Morishita, Yoichi Takami, Yasushi Kikuchi, Hiroki Hayashi, Tomoyuki Nishikawa, Katsuto Tamai, Nobuyoshi Azuma, Tadahiro Sasajima, Yasufumi Kaneda

CIRCULATION　Vol. 114　No. 11　p. 1177-1184　2006/09　Research paper (scientific journal)

Novel drug delivery system by surface modified magnetic nanoparticles

Shin-ichi Takeda, Bungo Terazono, Fumihito Mishima, Hironori Nakagami, Shigehiro Nishijima, Yasufumi Kaneda

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　Vol. 6　No. 9-10　p. 3269-3276　2006/09　Research paper (scientific journal)

[Endothelial cell growth inhibitory gene].

Nakagami H, Kaneda T, Nihon rinsho, Japanese journal of clinical medicine, Suppl

Vol. 64 Suppl 5　p. 428-431　2006/07

Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine

Hironori Nakagami, Namika Nakagawa, Yasushi Takeya, Katsunobu Kashiwagi, Chisato Ishida, Shin-ichiro Hayashi, Motokuni Aoki, Kunio Matsumoto, Toshikazu Nakamura, Toshio Ogihara, Ryuichi Morishita

HYPERTENSION　Vol. 48　No. 1　p. 112-119　2006/07　Research paper (scientific journal)

NF kappa B decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts

H Shimizu, H Nakagami, Tsukamoto, I, S Morita, Y Kunugiza, T Tomita, H Yoshikawa, Y Kaneda, T Ogihara, R Morishita

GENE THERAPY　Vol. 13　No. 12　p. 933-941　2006/06　Research paper (scientific journal)

Translational research in gene therapy

Hironori Nakagami, Ryuichi Morishita

Biotherapy　Vol. 20　No. 3　p. 305-309　2006/05　Research paper (scientific journal)

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4

F Xiang, Y Sakata, L Cui, JM Youngblood, H Nakagami, JK Liao, RL Liao, MT Chin

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY　Vol. 290　No. 5　p. H1997-H2006　2006/05　Research paper (scientific journal)

Development of high-throughput functional screening of therapeutic genes, using a hemagglutinating virus of Japan envelope vector

T Nishikawa, H Nakagami, A Matsuki, A Maeda, CY Yo, T Harada, R Morishita, K Tamai, Y Kaneda

HUMAN GENE THERAPY　Vol. 17　No. 4　p. 470-475　2006/04　Research paper (scientific journal)

Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide

Hironori Nakagami, Naruya Tomita, Yasufumi Kaneda, Toshio Ogihara, Ryuichi Morishita

CURRENT PHARMACEUTICAL BIOTECHNOLOGY　Vol. 7　No. 2　p. 95-100　2006/04

Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy

H Nakagami, R Morishita, K Maeda, Y Kikuchi, T Ogihara, Y Kaneda

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　Vol. 13　No. 2　p. 77-81　2006/04

Application of NFkB decoy oligonucleotides to bone metabolic diseases - in vitro and in vivo studies

H. Shimizu, H. Nakagami, S. Morita, N. Yasumasa, R. Hanayama, T. Ogihara, R. Morishita

PROCEEDINGS OF THE XVIII CONGRESS OF THE EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO FACIAL SURGERY　p. 165-+　2006　Research paper (international conference proceedings)

Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells

H Nakagami, K Maeda, R Morishita, S Iguchi, T Nishikawa, Y Takami, Y Kikuchi, Y Saito, K Tamai, T Ogihara, Y Kaneda

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 25　No. 12　p. 2542-2547　2005/12　Research paper (scientific journal)

HVJ-Eベクターを用いたHigh Throughput Screeningによる新規遺伝子機能スクリーニング 血管リモデリング抑制遺伝子の検索

鷹見 洋一, 中神 啓徳, 勝谷 友宏, 楽木 宏実, 森下 竜一, 金田 安史, 荻原 俊男

日本高血圧学会総会プログラム・抄録集　Vol. 28回　p. 84-84　2005/09

Hepatocyte growth factor(HGF)によるリンパ管新生作用

斉藤 幸裕, 中神 啓徳, 鷹見 洋一, 森下 竜一, 金田 安史, 東 信良, 笹嶋 唯博

日本高血圧学会総会プログラム・抄録集　Vol. 28回　p. 87-87　2005/09

Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector

N Morishita, H Nakagami, R Morishita, S Takeda, F Mishima, B Terazono, S Nishijima, Y Kaneda, N Tanaka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 334　No. 4　p. 1121-1126　2005/09　Research paper (scientific journal)

Hepatocyte growth factor as potential cardiovascular therapy

Hironori Nakagami, Yasufumi Kaneda, Toshio Ogihara, Ryuichi Morishita

Expert Review of Cardiovascular Therapy　Vol. 3　No. 3　p. 513-519　2005/05

Fundamental Study on Gene Therapy Utilizing Ferromagnetic Nanoparticles

Yoko Akiyama, Bungo Terazono, Fumihito Mishima, Shin-ichi Takeda, Yoshinobu Izumi, Kimiko Ema, Hironori Nakagami, Yasushi Kaneda, Shigehiro Nishijima

Abstract Book of 3rd International Symposium of 21stCentury COE "Towards Creating New Industries Based on Inter-Nanoscience"2005,p.107-108.　2005/03　Research paper (other academic)

Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis.

Nakagami H, Kaneda Y, Ogihara T, Morishita R, Current diabetes reviews

CURRENT DIABETES REVIEWS　Vol. 1　No. 1　p. 59-63　2005/02　Research paper (scientific journal)

Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: Role of Bcl-2, Bcl-xL and Bax in tubular injury

K Yamamoto, N Tomita, S Yoshimura, H Nakagami, Y Taniyama, K Yamasaki, T Ogihara, R Morishita

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE　Vol. 14　No. 4　p. 633-640　2004/10　Research paper (scientific journal)

Statins and myocardial hypertrophy

H Nakagami, JK Liao

CORONARY ARTERY DISEASE　Vol. 15　No. 5　p. 247-250　2004/08

Pharmacogenomics and Translational Research

NAKAGAMI Hironori

Jpn. J. Clin. Pharmacol. Ther.　Vol. 35　No. 3　p. 124-128　2004/05/31

Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells

H Nakagami, R Morishita, T Nishikawa, H Shimizu, S Iguchi, K Matsumoto, T Nakamura, Y Kaneda, T Ogihara

HYPERTENSION RESEARCH　Vol. 27　No. 5　p. 359-365　2004/05　Research paper (scientific journal)

No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice

A Matsuki, S Yamamoto, H Nakagami, M Aoki, K Tamai, K Matsumoto, T Nakamura, T Ogihara, Y Kaneda, R Morishita

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 315　No. 1　p. 59-65　2004/02　Research paper (scientific journal)

NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy

H Nakagami, M Takemoto, JK Liao

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY　Vol. 35　No. 7　p. 851-859　2003/07　Research paper (scientific journal)

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms

H Nakagami, KS Jensen, JK Liao

ANNALS OF MEDICINE　Vol. 35　No. 6　p. 398-403　2003

HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model

M Nakabayashi, R Morishita, H Nakagami, K Kuba, K Matsumoto, T Nakamura, Y Tano, Y Kaneda

DIABETOLOGIA　Vol. 46　No. 1　p. 115-123　2003/01　Research paper (scientific journal)

Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation

M Horiuchi, TX Cui, Z Li, JM Li, H Nakagami, M Iwai

CIRCULATION　Vol. 107　No. 1　p. 106-112　2003/01　Research paper (scientific journal)

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2

Y Sakata, CN Kamei, H Nakagami, R Bronson, JK Liao, MT Chin

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 99　No. 25　p. 16197-16202　2002/12　Research paper (scientific journal)

Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells

TX Cui, H Nakagami, C Nahmias, T Shiuchi, Y Takeda-Matsubara, JM Li, L Wu, M Iwai, M Horiuchi

MOLECULAR ENDOCRINOLOGY　Vol. 16　No. 9　p. 2113-2123　2002/09　Research paper (scientific journal)

ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO

T Shiuchi, TX Cui, L Wu, H Nakagami, Y Takeda-Matsubara, M Iwai, M Horiuchi

HYPERTENSION　Vol. 40　No. 3　p. 329-334　2002/09　Research paper (scientific journal)

Role of angiotensin II-regulated apoptosis through distinct AT(1) and AT(2) receptors in neointimal formation

J Suzuki, M Iwai, H Nakagami, L Wu, R Chen, T Sugaya, M Hamada, K Hiwada, M Horiuchi

CIRCULATION　Vol. 106　No. 7　p. 847-853　2002/08　Research paper (scientific journal)

Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane

H Nakagami, R Morishita, K Yamamoto, Y Taniyama, M Aoki, K Yamasaki, K Matsumoto, T Nakamura, Y Kaneda, T Ogihara

DIABETES　Vol. 51　No. 8　p. 2604-2611　2002/08　Research paper (scientific journal)

N141I mutant Presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression

M Mori, H Nakagami, R Morishita, N Mitsuda, K Yamamoto, S Yoshimura, N Ohkubo, N Sato, T Ogihara, Y Kaneda

LIFE SCIENCES　Vol. 70　No. 21　p. 2567-2580　2002/04　Research paper (scientific journal)

Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells

H Nakagami, TX Cui, M Iwai, T Shiuchi, Y Takeda-Matsubara, L Wu, M Horiuchi

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 22　No. 2　p. 238-242　2002/02　Research paper (scientific journal)

Estrogen activates phosphatases and antagonizes growth-promoting effect of angiotensin II

Y Takeda-Matsubara, H Nakagami, M Iwai, TX Cui, T Shiuchi, M Akishita, C Nahmias, M Ito, M Horiuchi

HYPERTENSION　Vol. 39　No. 1　p. 41-45　2002/01　Research paper (scientific journal)

Effect of angiotensin II type 1 receptor blockade on cardiac remodeling in angiotensin II type 2 receptor null mice

L Wu, M Iwai, H Nakagami, R Chen, J Suzuki, M Akishita, M de Gasparo, M Horiuchi

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 22　No. 1　p. 49-54　2002/01　Research paper (scientific journal)

Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model - Molecular mechanisms of delayed angiogenesis in diabetes

Y Taniyama, R Morishita, K Hiraoka, M Aoki, H Nakagami, K Yamasaki, K Matsumoto, T Nakamura, Y Kaneda, T Ogihara

CIRCULATION　Vol. 104　No. 19　p. 2344-2350　2001/11　Research paper (scientific journal)

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

M Takemoto, K Node, H Nakagami, YL Liao, M Grimm, Y Takemoto, M Kitakaze, JK Liao

JOURNAL OF CLINICAL INVESTIGATION　Vol. 108　No. 10　p. 1429-1437　2001/11　Research paper (scientific journal)

Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury

L Wu, M Iwai, H Nakagami, Z Li, R Chen, J Suzuki, M Akishita, M de Gasparo, M Horiuchi

CIRCULATION　Vol. 104　No. 22　p. 2716-2721　2001/11　Research paper (scientific journal)

Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element "decoy' of nuclear factor-kB binding site as a novel molecular strategy

S Yoshimura, R Morishita, K Hayashi, K Yamamoto, H Nakagami, Y Kaneda, N Sakai, T Ogihara

GENE THERAPY　Vol. 8　No. 21　p. 1635-1642　2001/11　Research paper (scientific journal)

Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons

K Hayashi, R Morishita, H Nakagami, S Yoshimura, A Hara, K Matsumoto, T Nakamura, T Ogihara, Y Kaneda, N Sakai

GENE THERAPY　Vol. 8　No. 15　p. 1167-1173　2001/08　Research paper (scientific journal)

Endothelial apoptosis induced by oxidative stress through activation of NF-kappa B - Antiapoptotic effect of antioxidant agents on endothelial cells

M Aoki, T Nata, R Morishita, H Matsushita, H Nakagami, K Yamamoto, K Yamazaki, M Nakabayashi, T Ogihara, Y Kaneda

HYPERTENSION　Vol. 38　No. 1　p. 48-55　2001/07　Research paper (scientific journal)

Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells

H Nakagami, R Morishita, K Yamamoto, S Yoshimura, Y Taniyama, M Aoki, H Matsubara, S Kim, Y Kaneda, T Ogihara

DIABETES　Vol. 50　No. 6　p. 1472-1481　2001/06　Research paper (scientific journal)

Contribution of Bcl-2, but not Bcl-xL and Bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells

K Yamamoto, R Morishita, S Hayashi, H Matsushita, H Nakagami, A Moriguchi, K Matsumoto, T Nakamura, Y Kaneda, T Ogihara

HYPERTENSION　Vol. 37　No. 5　p. 1341-1348　2001/05　Research paper (scientific journal)

Pivotal role of tyrosine phosphatase SHP-1 in AT2 receptor-mediated apoptosis in rat fetal vascular smooth muscle cell

TX Cui, H Nakagami, M Iwai, Y Takeda, T Shiuchi, L Daviet, C Nahmias, M Horiuchi

CARDIOVASCULAR RESEARCH　Vol. 49　No. 4　p. 863-871　2001/03　Research paper (scientific journal)

Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease

Y Taniyama, R Morishita, M Aoki, H Nakagami, K Yamamoto, K Yamazaki, K Matsumoto, T Nakamura, Y Kaneda, T Ogihara

GENE THERAPY　Vol. 8　No. 3　p. 181-189　2001/02　Research paper (scientific journal)

Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and Akt in endothelial cells

H Nakagami, R Morishita, K Yamamoto, Y Taniyama, M Aoki, K Matsumoto, T Nakamura, Y Kaneda, M Horiuchi, T Ogihara

HYPERTENSION　Vol. 37　No. 2　p. 581-586　2001/02　Research paper (scientific journal)

Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle

T Shiuchi, H Nakagami, M Iwai, Y Takeda, TX Cui, R Chen, Y Minokoshi, M Horiuchi

ENDOCRINOLOGY　Vol. 142　No. 2　p. 608-612　2001/02　Research paper (scientific journal)

ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth

TX Cui, H Nakagami, M Iwai, Y Takeda, T Shiuchi, K Tamura, L Daviet, M Horiuchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 279　No. 3　p. 938-941　2000/12　Research paper (scientific journal)

Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells

H Nakagami, R Morishita, K Yamamoto, Y Taniyama, M Aoki, S Kim, K Matsumoto, T Nakamura, J Higaki, T Ogihara

JOURNAL OF HYPERTENSION　Vol. 18　No. 10　p. 1411-1420　2000/10　Research paper (scientific journal)

Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model - Potential application of ribozyme strategy to treat cardiovascular disease

K Yamamoto, R Morishita, N Tomita, T Shimozato, H Nakagami, A Kikuchi, M Aoki, J Higaki, Y Kaneda, T Ogihara

CIRCULATION　Vol. 102　No. 11　p. 1308-1314　2000/09　Research paper (scientific journal)

Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters

Y Taniyama, R Morishita, H Nakagami, A Moriguchi, H Sakonjo, Shokei-Kim, K Matsumoto, T Nakamura, J Higaki, T Ogihara

CIRCULATION　Vol. 102　No. 2　p. 246-+　2000/07　Research paper (scientific journal)

Hypoxia-induced endothelial apoptosis through nuclear factor-kappa B (NF-kappa B)-mediated bcl-2 suppression - In vivo evidence of the importance of NF-kappa B in endothelial cell regulation

H Matsushita, R Morishita, T Nata, M Aoki, H Nakagami, Y Taniyama, K Yamamoto, J Higaki, K Yasufumi, T Ogihara

CIRCULATION RESEARCH　Vol. 86　No. 9　p. 974-981　2000/05　Research paper (scientific journal)

Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smooth muscle cells

H Matsushita, R Morishita, M Aoki, N Tomita, Y Taniyama, H Nakagami, T Shimozato, J Higaki, Y Kaneda, T Ogihara

CIRCULATION　Vol. 101　No. 12　p. 1447-1452　2000/03　Research paper (scientific journal)

Contribution of cardiovascular hypersensitivity to orthostatic hypertension and the extreme dipper phenomenon

A Moriguchi, H Nakagami, N Kotani, J Higaki, T Ogihara

HYPERTENSION RESEARCH　Vol. 23　No. 2　p. 119-123　2000/03　Research paper (scientific journal)

Gene therapy for myocardial infarction: A real medicine in the next millenium?

R Morishita, M Aoki, H Nakagami, Y Taniyama, K Yamamoto, H Matsushita, K Matsumoto, J Higaki, Y Kaneda, T Ogihara

HEART FAILURE　p. 219-226　2000　Research paper (international conference proceedings)

Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21

S Hayashi, R Morishita, H Matsushita, H Nakagami, Y Taniyama, T Nakamura, M Aoki, K Yamamoto, J Higaki, T Ogihara

HYPERTENSION　Vol. 35　No. 1　p. 237-243　2000/01　Research paper (scientific journal)

Isolation and characterization of the E2F-like gene in plants

M Sekine, M Ito, K Uemukai, Y Maeda, H Nakagami, A Shinmyo

FEBS LETTERS　Vol. 460　No. 1　p. 117-122　1999/10　Research paper (scientific journal)

Coronary artery disease and endothelial nitric oxide synthase and angiotensin-converting enzyme gene polymorphisms

H Nakagami, U Ikeda, Y Maeda, K Yamamoto, Y Hojo, K Kario, S Kuroki, K Shimada

JOURNAL OF THROMBOSIS AND THROMBOLYSIS　Vol. 8　No. 3　p. 191-195　1999/10　Research paper (scientific journal)

Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells - Potential role of p53 in regulation of vascular smooth muscle cell growth

M Aoki, R Morishita, H Matsushita, S Hayashi, H Nakagami, K Yamamoto, A Moriguchi, Y Kaneda, J Higaki, T Ogihara

HYPERTENSION　Vol. 34　No. 2　p. 192-200　1999/08　Research paper (scientific journal)

Relative localization of angiotensin-converting enzyme, chymase and angiotensin II in human coronary atherosclerotic lesions

OHISHI M, UEDA M, RAKUGI H, NARUKO T, KOJIMA A, OKAMURA A, HIGAKI J, OGIHARA T

Journal of Hypertension　Vol. 17　No. 4　p. 547-553　1999　Research paper (scientific journal)

血管内皮細胞における肝細胞増殖因子(HGF)の役割

中神 啓徳, 森下 竜一, 林 真一郎, 松下 英嗣, 山本 圭, 冨田 奈留也, 守口 篤, 檜垣 実男, 荻原 俊男

動脈硬化　Vol. 26　No. Suppl.1　p. 139-139　1998/11

Recurrent arterial thrombotic disease on young onset and protein S deficiency

H Nakagami, K Kario, T Mitsuhashi, H Fujikawa, U Ikeda, K Shimada

BLOOD COAGULATION & FIBRINOLYSIS　Vol. 9　No. 7　p. 667-668　1998/10

Mitral regurgitation reduces the risk of stroke in patients with nonrheumatic atrial fibrillation

H Nakagami, K Yamamoto, U Ikeda, T Mitsuhashi, T Goto, K Shimada

AMERICAN HEART JOURNAL　Vol. 136　No. 3　p. 528-532　1998/09　Research paper (scientific journal)

Oligonucleotide-based gene therapy for cardiovascular disease

R Morishita, H Nakagami, Y Taniyama, H Matsushita, K Yamamoto, N Tomita, A Moriguchi, K Matsumoto, J Higaki, T Ogihara

CLINICAL CHEMISTRY AND LABORATORY MEDICINE　Vol. 36　No. 8　p. 529-534　1998/08　Research paper (scientific journal)

Angiotensin converting enzyme gene polymorphism in essential hypertension based on ambulatory blood pressure monitoring

Y Maeda, U Ikeda, H Ebata, Y Hojo, Y Seino, H Nakagami, K Shimada

AMERICAN JOURNAL OF HYPERTENSION　Vol. 10　No. 7　p. 786-789　1997/07　Research paper (scientific journal)

Diurnal blood pressure rhythm in hypertensives with parental history of stroke

Y Maeda, U Ikeda, H Ebata, Y Hojo, H Nakagami, K Shimada

AMERICAN JOURNAL OF HYPERTENSION　Vol. 10　No. 5　p. 562-564　1997/05　Research paper (scientific journal)

Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans

OHISHI M, UEDA M, RAKUGI H, NARUKO T, KOJIMA A, OKAMURA A, HIGAKI J, OGIHARA T

Journal of Hypertension　Vol. 15　No. 11　p. 1295-1302　1997　Research paper (scientific journal)