Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice.

Shota Shimizu, Tomohiro Iba, Hisamichi Naito, Fitriana Nur Rahmawati, Hirotaka Konishi, Weizhen Jia, Fumitaka Muramatsu, Nobuyuki Takakura

Angiogenesis　Vol. 26　No. 4　p. 567-580　2023/11　Research paper (scientific journal)

癌細胞由来のアペリンはEMTを調整することにより転移を促進する(Cancer cell-derived apelin promotes metastasis by regulating EMT)

犬飼 公一, 黄瀬 一慶, 林 弓美子, 村松 史隆, Jia Weizhen, 木戸屋 浩康, 高倉 伸幸

日本癌学会総会記事　Vol. 82回　p. 2045-2045　2023/09

Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver.

Fitriana N Rahmawati, Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Hirotaka Konishi, Weizhen Jia, Nobuyuki Takakura

Stem cell research & therapy　Vol. 14　No. 1　p. 227-227　2023/08/30　Research paper (scientific journal)

[Vascular biology and hemophilia].

Nobuyuki Takakura

[Rinsho ketsueki] The Japanese journal of clinical hematology　Vol. 64　No. 7　p. 661-664　2023/07/01　Research paper (scientific journal)

Cancer apelin receptor suppresses vascular mimicry in malignant melanoma.

Koichi Inukai, Kazuyoshi Kise, Yumiko Hayashi, Weizhen Jia, Fumitaka Muramatsu, Naoki Okamoto, Hirotaka Konishi, Keigo Akuta, Hiroyasu Kidoya, Nobuyuki Takakura

Pathology oncology research : POR　Vol. 29　p. 1610867-1610867　2023/01/27　Research paper (scientific journal)

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

Maaya Morita, Aki Yoneda, Nagisa Tokunoh, Tatsumi Masaki, Keisuke Shirakura, Mayumi Kinoshita, Rina Hashimoto, Naoya Shigesada, Junya Takahashi, Masashi Tachibana, Shota Tanaka, Masanori Obana, Nobumasa Hino, Masahito Ikawa, Kazutake Tsujikawa, Chikako Ono, Yoshiharu Matsuura, Hiroyasu Kidoya, Nobuyuki Takakura, Yoshiaki Kubota, Takefumi Doi, Kazuo Takayama, Yasuo Yoshioka, Yasushi Fujio, Yoshiaki Okada

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 3　2023/01/17　Research paper (scientific journal)

Blood vessels sense dermal stiffness via a novel mechanotransducer, APJ.

Mika Sawane, Yuki Ogura, Ayano Nakamura, Hitomi Otaka, Hiroyasu Kidoya, Katsujiro Sato, Nobuyuki Takakura, Kentaro Kajiya

Angiogenesis　Vol. 25　No. 2　p. 151-154　2022/05/01　Research paper (scientific journal)

Apelin Resistance Contributes to Muscle Loss during Cancer Cachexia in Mice.

Andrea David Re Cecconi, Mara Barone, Mara Forti, Martina Lunardi, Alfredo Cagnotto, Mario Salmona, Davide Olivari, Lorena Zentilin, Andrea Resovi, Perla Persichitti, Dorina Belotti, Federica Palo, Nobuyuki Takakura, Hiroyasu Kidoya, Rosanna Piccirillo

Cancers　Vol. 14　No. 7　2022/04/02　Research paper (scientific journal)

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis.

Taku Wakabayashi, Hisamichi Naito, Tomohiro Iba, Kohji Nishida, Nobuyuki Takakura

Investigative ophthalmology & visual science　Vol. 63　No. 4　p. 5-5　2022/04/01　Research paper (scientific journal)

Reduction in miR-219 expression underlies cellular pathogenesis of oligodendrocytes in a mouse model of Krabbe disease

Naoko Inamura, Shinji Go, Takashi Watanabe, Hiroshi Takase, Nobuyuki Takakura, Atsuo Nakayama, Hirohide Takebayashi, Junko Matsuda, Yasushi Enokido

Brain Pathology　Vol. 31　No. 5　2021/09/01　Research paper (scientific journal)

Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization

Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura

Scientific Reports　Vol. 11　No. 1　2021/07/01　Research paper (scientific journal)

Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells

Hisamichi Naito, Tomohiro Iba, Nobuyuki Takakura

International Immunology　Vol. 32　No. 5　p. 295-305　2021/05/01　Research paper (scientific journal)

Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells

Weizhen Jia, Lingyu Kong, Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Yumiko Hayashi, Han Yun Hsieh, Daishi Yamakawa, Daniel K. Hsu, Fu Tong Liu, Nobuyuki Takakura

Nature Communications　Vol. 12　No. 1　2021/04/01　Research paper (scientific journal)

Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling

Masumi Ito, Rieko Muramatsu, Yuki Kato, Bikram Sharma, Akiko Uyeda, Shogo Tanabe, Harutoshi Fujimura, Hiroyasu Kidoya, Nobuyuki Takakura, Yukio Kawahara, Masaki Takao, Hideki Mochizuki, Akiyoshi Fukamizu, Toshihide Yamashita

Nature Aging　Vol. 1　No. 3　p. 284-294　2021/03　Research paper (scientific journal)

An in vivo model allowing continuous observation of human vascular formation in the same animal over time

Yohei Tsukada, Fumitaka Muramatsu, Yumiko Hayashi, Chiaki Inagaki, Hang Su, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura

Scientific Reports　Vol. 11　No. 1　2020/12/01　Research paper (scientific journal)

The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis

Kentaro Tsukamoto, Naoaki Shinzawa, Akito Kawai, Masahiro Suzuki, Hiroyasu Kidoya, Nobuyuki Takakura, Hisateru Yamaguchi, Toshiki Kameyama, Hidehito Inagaki, Hiroki Kurahashi, Yasuhiko Horiguchi, Yohei Doi

Nature Communications　Vol. 11　No. 1　2020/12/01　Research paper (scientific journal)

Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages

Kenta Maruyama, Hiroyasu Kidoya, Naoki Takemura, Erika Sugisawa, Osamu Takeuchi, Takeshi Kondo, Mohammed Mansour Abbas Eid, Hiroki Tanaka, Mikaël M. Martino, Nobuyuki Takakura, Yasunori Takayama, Shizuo Akira, Alexis Vandenbon, Yutaro Kumagai

Cell Reports　Vol. 32　No. 2　p. 107906-107906　2020/07/14　Research paper (scientific journal)

High expression of PSF1 promotes drug resistance and cell cycle transit in leukemia cells

Han Yun Hsieh, Weizhen Jia, Ze cheng Jin, Hiroyasu Kidoya, Nobuyuki Takakura

Cancer Science　Vol. 111　No. 7　p. 2400-2412　2020/07/01　Research paper (scientific journal)

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Hidefumi Mimura, Sadanori Akita, Akihiro Fujino, Masatoshi Jinnin, Mine Ozaki, Keigo Osuga, Hiroki Nakaoka, Eiichi Morii, Akira Kuramochi, Yoko Aoki, Yasunori Arai, Noriko Aramaki, Masanori Inoue, Yuki Iwashina, Tadashi Iwanaka, Shigeru Ueno, Akihiro Umezawa, Michio Ozeki, Junko Ochi, Yoshiaki Kinoshita, Masakazu Kurita, Shien Seike, Nobuyuki Takakura, Masataka Takahashi, Takao Tachibana, Kumiko Chuman, Shuji Nagata, Mitsunaga Narushima, Yasunari Niimi, Shunsuke Nosaka, Taiki Nozaki, Kazuki Hashimoto, Ayato Hayashi, Satoshi Hirakawa, Atsuko Fujikawa, Yumiko Hori, Kentaro Matsuoka, Hideki Mori, Yuki Yamamoto, Shunsuke Yuzuriha, Naoaki Rikihisa, Shoji Watanabe, Shinichi Watanabe, Tatsuo Kuroda, Shunsuke Sugawara, Kosuke Ishikawa, Satoru Sasaki

Journal of Dermatology　Vol. 47　No. 5　p. e138-e183　2020/05/01　Research paper (scientific journal)

Japanese clinical practice guidelines for vascular anomalies 2017

Hidefumi Mimura, Sadanori Akita, Akihiro Fujino, Masatoshi Jinnin, Mine Ozaki, Keigo Osuga, Hiroki Nakaoka, Eiichi Morii, Akira Kuramochi, Yoko Aoki, Yasunori Arai, Noriko Aramaki, Masanori Inoue, Yuki Iwashina, Tadashi Iwanaka, Shigeru Ueno, Akihiro Umezawa, Michio Ozeki, Junko Ochi, Yoshiaki Kinoshita, Masakazu Kurita, Shien Seike, Nobuyuki Takakura, Masataka Takahashi, Takao Tachibana, Kumiko Chuman, Shuji Nagata, Mitsunaga Narushima, Yasunari Niimi, Shunsuke Nosaka, Taiki Nozaki, Kazuki Hashimoto, Ayato Hayashi, Satoshi Hirakawa, Atsuko Fujikawa, Yumiko Hori, Kentaro Matsuoka, Hideki Mori, Yuki Yamamoto, Shunsuke Yuzuriha, Naoaki Rikihisa, Shoji Watanabe, Shinichi Watanabe, Tatsuo Kuroda, Shunsuke Sugawara, Kosuke Ishikawa, Satoru Sasaki

Japanese Journal of Radiology　Vol. 38　No. 4　p. 287-342　2020/04/01　Research paper (scientific journal)

Japanese clinical practice guidelines for vascular anomalies 2017

Hidefumi Mimura, Sadanori Akita, Akihiro Fujino, Masatoshi Jinnin, Mine Ozaki, Keigo Osuga, Hiroki Nakaoka, Eiichi Morii, Akira Kuramochi, Yoko Aoki, Yasunori Arai, Noriko Aramaki, Masanori Inoue, Yuki Iwashina, Tadashi Iwanaka, Shigeru Ueno, Akihiro Umezawa, Michio Ozeki, Junko Ochi, Yoshiaki Kinoshita, Masakazu Kurita, Shien Seike, Nobuyuki Takakura, Masataka Takahashi, Takao Tachibana, Kumiko Chuman, Shuji Nagata, Mitsunaga Narushima, Yasunari Niimi, Shunsuke Nosaka, Taiki Nozaki, Kazuki Hashimoto, Ayato Hayashi, Satoshi Hirakawa, Atsuko Fujikawa, Yumiko Hori, Kentaro Matsuoka, Hideki Mori, Yuki Yamamoto, Shunsuke Yuzuriha, Naoaki Rikihisa, Shoji Watanabe, Shinichi Watanabe, Tatsuo Kuroda, Shunsuke Sugawara, Kosuke Ishikawa, Satoru Sasaki

Pediatrics International　Vol. 62　No. 3　p. 257-304　2020/03/01

Isolation of tissue-resident vascular endothelial stem cells from mouse liver

Hisamichi Naito, Taku Wakabayashi, Masako Ishida, Chang Hyun Gil, Tomohiro Iba, Fitriana Nur Rahmawati, Shota Shimizu, Mervin C. Yoder, Nobuyuki Takakura

Nature Protocols　Vol. 15　No. 3　p. 1066-1081　2020/03/01　Research paper (scientific journal)

Loss of down syndrome critical region-1 mediated-hypercholesterolemia accelerates corneal opacity via pathological neovessel formation

Masashi Muramatsu, Suguru Nakagawa, Tsuyoshi Osawa, Tetsuya Toyono, Akiyoshi Uemura, Hiroyasu Kidoya, Nobuyuki Takakura, Tomohiko Usui, Sandra Ryeom, Takashi Minami

Arteriosclerosis, Thrombosis, and Vascular Biology　Vol. 40　No. 10　p. 2425-2439　2020　Research paper (scientific journal)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Hiroyasu Kidoya, Fumitaka Muramatsu, Teppei Shimamura, Weizhen Jia, Takashi Satoh, Yumiko Hayashi, Hisamichi Naito, Yuya Kunisaki, Fumio Arai, Masahide Seki, Yutaka Suzuki, Tsuyoshi Osawa, Shizuo Akira, Nobuyuki Takakura

Nature Communications　Vol. 10　No. 1　p. 1072-1072　2019/12/01　Research paper (scientific journal)

Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development

Mariko Komabayashi-Suzuki, Emiko Yamanishi, Chisato Watanabe, Megumi Okamura, Hidenori Tabata, Ryota Iwai, Itsuki Ajioka, Jun Matsushita, Hiroyasu Kidoya, Nobuyuki Takakura, Tadashi Okamoto, Kazuo Kinoshita, Masamitsu Ichihashi, Koh ichi Nagata, Masatsugu Ema, Ken ichi Mizutani

Cell Reports　Vol. 29　No. 5　p. 1113-1129.e5　2019/10/29　Research paper (scientific journal)

Embryonic expression of GINS members in the development of the mammalian nervous system

Weizhen Jia, Han Yun Hsieh, Hiroyasu Kidoya, Nobuyuki Takakura

Neurochemistry International　Vol. 129　2019/10　Research paper (scientific journal)

Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling

Riikka Kivelä, Karthik Amudhala Hemanthakumar, Katri Vaparanta, Marius Robciuc, Yasuhiro Izumiya, Hiroyasu Kidoya, Nobuyuki Takakura, Xuyang Peng, Douglas B. Sawyer, Klaus Elenius, Kenneth Walsh, Kari Alitalo

Circulation　Vol. 139　No. 22　p. 2570-2584　2019/05/28　Research paper (scientific journal)

Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine

Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi, Nobuyuki Takakura

Inflammation and Regeneration　Vol. 39　No. 1　2019/05/08　Research paper (scientific journal)

TAK1 safeguards endothelial cells from gut microbes and inflammation

Hisamichi Naito, Nobuyuki Takakura

Molecular and Cellular Oncology　Vol. 6　No. 3　2019/05/04　Research paper (scientific journal)

Galectin-3 Inhibits Cancer Metastasis by Negatively Regulating Integrin β3 Expression

Yumiko Hayashi, Weizhen Jia, Hiroyasu Kidoya, Fumitaka Muramatsu, Yohei Tsukada, Nobuyuki Takakura

American Journal of Pathology　Vol. 189　No. 4　p. 900-910　2019/04　Research paper (scientific journal)

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain

Thành Chung Đặng, Yoko Ishii, Van De Nguyen, Seiji Yamamoto, Takeru Hamashima, Noriko Okuno, Quang Linh Nguyen, Yang Sang, Noriaki Ohkawa, Yoshito Saitoh, Mohammad Shehata, Nobuyuki Takakura, Toshihiko Fujimori, Kaoru Inokuchi, Hisashi Mori, Johanna Andrae, Christer Betsholtz, Masakiyo Sasahara

Cell Reports　Vol. 27　No. 4　p. 1073-1089.e5　2019/04　Research paper (scientific journal)

Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma

Tokuhiro Kimura, Dan Cui, Hiroo Kawano, Chihiro Yoshitomi-Sakamoto, Nobuyuki Takakura, Eiji Ikeda

Journal of Cancer Research and Clinical Oncology　Vol. 145　No. 2　p. 363-371　2019/02/13　Research paper (scientific journal)

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Hisamichi Naito, Tomohiro Iba, Taku Wakabayashi, Ikue Tai-Nagara, Jun ichi Suehiro, Weizhen Jia, Daisuke Eino, Susumu Sakimoto, Fumitaka Muramatsu, Hiroyasu Kidoya, Hiroyuki Sakurai, Takashi Satoh, Shizuo Akira, Yoshiaki Kubota, Nobuyuki Takakura

Developmental Cell　Vol. 48　No. 2　p. 151-166.e7　2019/01/28　Research paper (scientific journal)

LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti–PD-1 Therapy against Brain Tumors

Daisuke Eino, Yohei Tsukada, Hisamichi Naito, Yonehiro Kanemura, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Hideyuki Arita, Naoki Kagawa, Yasunori Fujimoto, Kazuhiro Takara, Haruhiko Kishima, Nobuyuki Takakura

Cancer Research　Vol. 78　No. 23　p. 6607-6620　2018/12　Research paper (scientific journal)

Discovery of a Vascular Endothelial Stem Cell (VESC) Population Required for Vascular Regeneration and Tissue Maintenance.

Takakura N

Circulation journal : official journal of the Japanese Circulation Society　Vol. 83　No. 1　p. 12-17　2018/12　Research paper (scientific journal)

Developmental defects and aberrant accumulation of endogenous psychosine in oligodendrocytes in a murine model of Krabbe disease.

Inamura N, Kito M, Go S, Kishi S, Hosokawa M, Asai K, Takakura N, Takebayashi H, Matsuda J, Enokido Y

Neurobiology of disease　Vol. 120　p. 51-62　2018/12　Research paper (scientific journal)

Stromal PDGFR-β Expression is Associated with Postoperative Survival of Non-Small Cell Lung Cancer Patients Receiving Preoperative Chemo- or Chemoradiotherapy Followed by Surgery.

Ryu Kanzaki, Naoko Ose, Tomohiro Kawamura, Soichiro Funaki, Yasushi Shintani, Masato Minami, Nobuyuki Takakura, Meinoshin Okumura

World journal of surgery　Vol. 42　No. 9　p. 2879-2886　2018/09　Research paper (scientific journal)

Visualization of Proliferative Vascular Endothelial Cells in Tumors in Vivo by Imaging Their Partner of Sld5-1 Promoter Activity

Daishi Yamakawa, Weizhen Jia, Hiroyasu Kidoya, Shoko Hosojima, Miku Torigata, Li Zhang, Nobuyuki Takakura

American Journal of Pathology　Vol. 188　No. 5　p. 1300-1314　2018/05/01　Research paper (scientific journal)

Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.

Nakagawa K, Matsuki T, Zhao L, Kuniyoshi K, Tanaka H, Ebina I, Yoshida KJ, Nabeshima H, Fukushima K, Kanemaru H, Yamane F, Kawasaki T, Machida T, Naito H, Takakura N, Satoh T, Akira S

Int Immunol.　2018/03　Research paper (scientific journal)

CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties

Taku Wakabayashi, Hisamichi Naito, Jun-ichi Suehiro, Yang Lin, Hideya Kawaji, Tomohiro Iba, Tsukasa Kouno, Sachi Ishikawa-Kato, Masaaki Furuno, Kazuhiro Takara, Fumitaka Muramatsu, Jia Weizhen, Hiroyasu Kidoya, Katsuhiko Ishihara, Yoshihide Hayashizaki, Kohji Nishida, Mervin C. Yoder, Nobuyuki Takakura

Cell Stem Cell　Vol. 22　No. 3　p. 384-397.e6　2018/03/01　Research paper (scientific journal)

Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy

Ryu Kanzaki, Hisamichi Naito, Kazuyoshi Kise, Kazuhiro Takara, Daisuke Eino, Masato Minami, Yasushi Shintani, Soichiro Funaki, Tomohiro Kawamura, Toru Kimura, Meinoshin Okumura, Nobuyuki Takakura

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/09　Research paper (scientific journal)

Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency

Mari Yoshida, Yukichi Ishioka, Takamasa Ozawa, Hirohisa Okuyama, Motofumi Iguchi, Takeshi Ota, Takaomi Ito, Morio Nagira, Atsushi Morita, Hidekazu Tanaka, Hisamichi Naito, Hiroyasu Kidoya, Nobuyuki Takakura

SCIENTIFIC REPORTS　Vol. 7　No. 1　2017/09　Research paper (scientific journal)

Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats

Masafumi Hiramatsu, Tomohito Hishikawa, Koji Tokunaga, Hiroyasu Kidoya, Shingo Nishihiro, Jun Haruma, Tomohisa Shimizu, Yuji Takasugi, Yukei Shinji, Kenji Sugiu, Nobuyuki Takakura, Isao Date

JOURNAL OF NEUROSURGERY　Vol. 127　No. 3　p. 679-686　2017/09　Research paper (scientific journal)

Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact

Kazuhiro Takara, Daisuke Eino, Koji Ando, Daisuke Yasuda, Hisamichi Naito, Yohei Tsukada, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Shigetomo Fukuhara, Naoki Mochizuki, Satoshi Ishii, Haruhiko Kishima, Nobuyuki Takakura

CELL REPORTS　Vol. 20　No. 9　p. 2072-2086　2017/08　Research paper (scientific journal)

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Ikue Tai-Nagara, Yusuke Yoshikawa, Naoko Numata, Tomofumi Ando, Keisuke Okabe, Yuki Sugiura, Masaki Ieda, Nobuyuki Takakura, Osamu Nakagawa, Bin Zhou, Koji Okabayashi, Makoto Suematsu, Yuko Kitagawa, Martin Bastmeyer, Kohji Sato, Ruediger Klein, Sutip Navankasattusas, Dean Y. Li, Satoru Yamagishi, Yoshiaki Kubota

DEVELOPMENT　Vol. 144　No. 13　p. 2392-2401　2017/07　Research paper (scientific journal)

Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin

Fumitaka Muramatsu, Hiroyasu Kidoya, Hisamichi Naito, Yumiko Hayashi, Tomohiro Iba, Nobuyuki Takakura

JOURNAL OF BIOCHEMISTRY　Vol. 162　No. 1　p. 55-62　2017/07　Research paper (scientific journal)

Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer

Miku Torigata, Daishi Yamakawa, Nobuyuki Takakura

CANCER MEDICINE　Vol. 6　No. 6　p. 1378-1388　2017/06　Research paper (scientific journal)

Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.

Jun Matsushita, Shigenori Inagaki, Tomomi Nishie, Tomoki Sakasai, Junko Tanaka, Chisato Watanabe, Ken-Ichi Mizutani, Yoshihiro Miwa, Ken Matsumoto, Kazuhiro Takara, Hisamichi Naito, Hiroyasu Kidoya, Nobuyuki Takakura, Takeharu Nagai, Satoru Takahashi, Masatsugu Ema

Scientific reports　Vol. 7　p. 46597-46597　2017/04/20　Research paper (scientific journal)

Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.

Shuntaro Ogura, Kaori Kurata, Yuki Hattori, Hiroshi Takase, Toshina Ishiguro-Oonuma, Yoonha Hwang, Soyeon Ahn, Inwon Park, Wataru Ikeda, Sentaro Kusuhara, Yoko Fukushima, Hiromi Nara, Hideto Sakai, Takashi Fujiwara, Jun Matsushita, Masatsugu Ema, Masanori Hirashima, Takashi Minami, Masabumi Shibuya, Nobuyuki Takakura, Pilhan Kim, Takaki Miyata, Yuichiro Ogura, Akiyoshi Uemura

JCI insight　Vol. 2　No. 3　2017/02/09　Research paper (scientific journal)

PSF1 (Partner of SLD Five 1) is a Prognostic Biomarker in Patients with Non-small Cell Lung Cancer Treated with Surgery Following Preoperative Chemotherapy or Chemoradiotherapy

Ryu Kanzaki, Hisamichi Naito, Kazuyoshi Kise, Kazuhiro Takara, Daisuke Eino, Masato Minami, Yasushi Shintani, Soichiro Funaki, Tomohiro Kawamura, Toru Kimura, Meinoshin Okumura, Nobuyuki Takakura

ANNALS OF SURGICAL ONCOLOGY　Vol. 23　No. 12　p. 4093-4100　2016/11　Research paper (scientific journal)

Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells

Keitaro Yamane, Hisamichi Naito, Taku Wakabayashi, Hironori Yoshida, Fumitaka Muramatsu, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura

SCIENTIFIC REPORTS　Vol. 6　2016/08　Research paper (scientific journal)

APCA発現モデルラットにおける分子生物学的手法を用いた新生血管発生機序の解明

伊藤 怜司, 浦島 崇, 糸久 美紀, 河内 文江, 藤本 義隆, 森 琢磨, 藤原 優子, 小川 潔, 南沢 享, 内藤 尚道, 高倉 伸幸

日本小児循環器学会雑誌　Vol. 32　No. Suppl.1　p. s1-227　2016/07

Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance

Hisamichi Naito, Taku Wakabayashi, Hiroyasu Kidoya, Fumitaka Muramatsu, Kazuhiro Takara, Daisuke Eino, Keitaro Yamane, Tomohiro Iba, Nobuyuki Takakura

CANCER RESEARCH　Vol. 76　No. 11　p. 3200-3210　2016/06　Research paper (scientific journal)

Tumor microenvironment for cancer stem cells

Kazuyoshi Kise, Yumi Kinugasa-Katayama, Nobuyuki Takakura

ADVANCED DRUG DELIVERY REVIEWS　Vol. 99　No. Pt B　p. 197-205　2016/04

Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-alpha and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors

Supranee Phanthanawiboon, Kriengsak Limkittikul, Yusuke Sakai, Nobuyuki Takakura, Masayuki Saijo, Takeshi Kurosu

PLOS ONE　Vol. 11　No. 2　2016/02　Research paper (scientific journal)

Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy

Li Zhang, Kazuhiro Takara, Daishi Yamakawa, Hiroyasu Kidoya, Nobuyuki Takakura

CANCER SCIENCE　Vol. 107　No. 1　p. 36-44　2016/01　Research paper (scientific journal)

Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial beta 1 integrin recycling

Tsunaki Hongu, Yuji Funakoshi, Shigetomo Fukuhara, Teruhiko Suzuki, Susumu Sakimoto, Nobuyuki Takakura, Masatsugu Ema, Satoru Takahashi, Susumu Itoh, Mitsuyasu Kato, Hiroshi Hasegawa, Naoki Mochizuki, Yasunori Kanaho

NATURE COMMUNICATIONS　Vol. 6　2015/08　Research paper (scientific journal)

Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors

Yinglu Han, Zhi-Yuan Gong, Nobuyuki Takakura

EXPERIMENTAL CELL RESEARCH　Vol. 334　No. 2　p. 183-193　2015/06　Research paper (scientific journal)

APJ Regulates Parallel Alignment of Arteries and Veins in the Skin

Hiroyasu Kidoya, Hisamichi Naito, Fumitaka Muramatsu, Daishi Yamakawa, Weizhen Jia, Masahito Ikawa, Takashi Sonobe, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Ralf H. Adams, Akiyoshi Fukamizu, Nobuyuki Takakura

DEVELOPMENTAL CELL　Vol. 33　No. 3　p. 247-259　2015/05　Research paper (scientific journal)

Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells

Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome, Koichi Miura, Shin Ishikane, Kentaro Otani, Ichiro Kishimoto, Yasushi Shintani, Masayoshi Inoue, Toru Kimura, Noriyoshi Sawabata, Masato Minami, Tomoyuki Nakagiri, Soichiro Funaki, Yukiyasu Takeuchi, Hajime Maeda, Hiroyasu Kidoya, Hiroshi Kiyonari, Go Shioi, Yuji Arai, Takeshi Hasegawa, Nobuyuki Takakura, Megumi Hori, Yuko Ohno, Mikiya Miyazato, Naoki Mochizuki, Meinoshin Okumura, Kenji Kangawa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 112　No. 13　p. 4086-4091　2015/03　Research paper (scientific journal)

Evaluation of PSF1 as a prognostic biomarker for prostate cancer

H. Tahara, H. Naito, K. Kise, T. Wakabayashi, K. Kamoi, K. Okihara, A. Yanagisawa, Y. Nakai, N. Nonomura, E. Morii, T. Miki, N. Takakura

PROSTATE CANCER AND PROSTATIC DISEASES　Vol. 18　No. 1　p. 56-62　2015/03　Research paper (scientific journal)

Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart.

Satoshi Kainuma, Shigeru Miyagawa, Satsuki Fukushima, James Pearson, Yi Ching Chen, Atsuhiro Saito, Akima Harada, Motoko Shiozaki, Hiroko Iseoka, Tadashi Watabe, Hiroshi Watabe, Genki Horitsugi, Mana Ishibashi, Hayato Ikeda, Hirotsugu Tsuchimochi, Takashi Sonobe, Yutaka Fujii, Hisamichi Naito, Keiji Umetani, Tatsuya Shimizu, Teruo Okano, Eiji Kobayashi, Takashi Daimon, Takayoshi Ueno, Toru Kuratani, Koichi Toda, Nobuyuki Takakura, Jun Hatazawa, Mikiyasu Shirai, Yoshiki Sawa

Molecular therapy : the journal of the American Society of Gene Therapy　Vol. 23　No. 2　p. 374-86　2015/02　Research paper (scientific journal)

DNA Damage Enhanced by the Attenuation of SLD5 Delays Cell Cycle Restoration in Normal Cells but Not in Cancer Cells

Zhi-Yuan Gong, Hiroyasu Kidoya, Tomomi Mohri, Yinglu Han, Nobuyuki Takakura

PLOS ONE　Vol. 9　No. 10　2014/10　Research paper (scientific journal)

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity

Shinichiro Yamamoto, Tetsuo Yamazaki, Shinji Komazaki, Takeshi Yamashita, Masako Osaki, Masaya Matsubayashi, Hiroyasu Kidoyaa, Nobuyuki Takakura, Daiju Yamazaki, Sho Kakizawa

DEVELOPMENTAL BIOLOGY　Vol. 393　No. 1　p. 33-43　2014/09　Research paper (scientific journal)

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

Kazuhide Ishikura, Hirofumi Misu, Masafumi Kumazaki, Hiroaki Takayama, Naoto Matsuzawa-Nagata, Natsumi Tajima, Keita Chikamoto, Fei Lan, Hitoshi Ando, Tsuguhito Ota, Masaru Sakurai, Yumie Takeshita, Kenichiro Kato, Akio Fujimura, Ken-ichi Miyamoto, Yoshiro Saito, Satomi Kameo, Yasuo Okamoto, Yoh Takuwa, Kazuhiko Takahashi, Hiroyasu Kidoya, Nobuyuki Takakura, Shuichi Kaneko, Toshinari Takamura

DIABETOLOGIA　Vol. 57　No. 9　p. 1968-1976　2014/09　Research paper (scientific journal)

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart

Yoh Arita, Yoshikazu Nakaoka, Taichi Matsunaga, Hiroyasu Kidoya, Kohei Yamamizu, Yuichiro Arima, Takahiro Kataoka-Hashimoto, Kuniyasu Ikeoka, Taku Yasui, Takeshi Masaki, Kaori Yamamoto, Kaori Higuchi, Jin-Sung Park, Manabu Shirai, Koichi Nishiyama, Hiroyuki Yamagishi, Kinya Otsu, Hiroki Kurihara, Takashi Minami, Keiko Yamauchi-Takihara, Gou Y. Koh, Naoki Mochizuki, Nobuyuki Takakura, Yasushi Sakata, Jun K. Yamashita, Issei Komuro

NATURE COMMUNICATIONS　Vol. 5　No. 4552　2014/07　Research paper (scientific journal)

Discovery of vascular resident endothelial stem/progenitor cell population

TAKAKURA Nobuyuki

Blood & Vessel　Vol. 25　No. 5　p. 603-608　2014

CD44 Expressed on Cancer-Associated Fibroblasts Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment

Yumi Kinugasa, Takahiro Matsui, Nobuyuki Takakura

STEM CELLS　Vol. 32　No. 1　p. 145-156　2014/01　Research paper (scientific journal)

Heregulin Induces Resistance to Lapatinib-mediated Growth Inhibition of HER2-Amplified Cancer Cells

Y. Sato, M. Yashiro, N. Takakura

Cell Cycle　2013/12　Research paper (scientific journal)

Vascular-resident endothelial side population cells

Hisamichi Naito, Nobuyuki Takakura

Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases　p. 67-84　2013/12/01　Part of collection (book)

Requirement of SLD5 for early embryogenesis

Tomomi Mohri, Masaya Ueno, Yumi Nagahama, Zhi-Yuan Gong, Masahide Asano, Hiroko Oshima, Masanobu Oshima, Yasushi Fujio, Nobuyuki Takakura

PLoS ONE　Vol. 8　No. 11　2013/11/11　Research paper (scientific journal)

Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity

Mika Sawane, Kentaro Kajiya, Hiroyasu Kidoya, Masaya Takagi, Fumitaka Muramatsu, Nobuyuki Takakura

Diabetes　Vol. 62　No. 6　p. 1970-1980　2013/06　Research paper (scientific journal)

Tumor Endothelial Cell-Specific Drug Delivery System Using Apelin-Conjugated Liposomes

Hiroki Kawahara, Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroyasu Kidoya, Nobuyuki Takakura

PLOS ONE　Vol. 8　No. 6　2013/06　Research paper (scientific journal)

Possible Role of Mural Cell-Covered Mature Blood Vessels in Inducing Drug Resistance in Cancer-Initiating Cells

Takahiro Matsui, Yumi Kinugasa, Hidekazu Tahara, Yuzuru Kanakura, Nobuyuki Takakura

AMERICAN JOURNAL OF PATHOLOGY　Vol. 182　No. 5　p. 1790-1799　2013/05　Research paper (scientific journal)

Ligand-independent Tie2 Dimers Mediate Kinase Activity Stimulated by High Dose Angiopoietin-1

Daishi Yamakawa, Hiroyasu Kidoya, Susumu Sakimoto, Weizhen Jia, Hisamichi Naito, Nobuyuki Takakura

JOURNAL OF BIOLOGICAL CHEMISTRY　Vol. 288　No. 18　p. 12469-12477　2013/05　Research paper (scientific journal)

Galectin-3 Accelerates M2 Macrophage Infiltration and Angiogenesis in Tumors

Weizhen Jia, Hiroyasu Kidoya, Daishi Yamakawa, Hisamichi Naito, Nobuyuki Takakura

AMERICAN JOURNAL OF PATHOLOGY　Vol. 182　No. 5　p. 1821-1831　2013/05　Research paper (scientific journal)

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Takashi Satoh, Hiroyasu Kidoya, Hisamichi Naito, Masahiro Yamamoto, Naoki Takemura, Katsuhiro Nakagawa, Yoshichika Yoshioka, Eiichi Morii, Nobuyuki Takakura, Osamu Takeuchi, Shizuo Akira

Nature　Vol. 495　No. 7442　p. 524-528　2013/03/28　Research paper (scientific journal)

An Angiogenic Role for Adrenomedullin in Choroidal Neovascularization

Susumu Sakimoto, Hiroyasu Kidoya, Motohiro Kamei, Hisamichi Naito, Daishi Yamakawa, Hirokazu Sakaguchi, Taku Wakabayashi, Kohji Nishida, Nobuyuki Takakura

PLOS ONE　Vol. 8　No. 3　2013/03　Research paper (scientific journal)

Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age- related macular degeneration

Taku Wakabayashi, Hisamichi Naito, Kazuhiro Takara, Hiroyasu Kidoya, Susumu Sakimoto, Yusuke Oshima, Kohji Nishida, Nobuyuki Takakura

Investigative Ophthalmology and Visual Science　Vol. 54　No. 10　p. 6686-6693　2013　Research paper (scientific journal)

microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin

F. Muramatsu, H. Kidoya, H. Naito, S. Sakimoto, N. Takakura

ONCOGENE　Vol. 32　No. 4　p. 414-421　2013/01　Research paper (scientific journal)

The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation

Kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, Tatsuya Saitoh, Takumi Kawasaki, Takeshi Kondo, Kazunari K. Yokoyama, Hiroyasu Kidoya, Nobuyuki Takakura, Daron Standley, Osamu Takeuchi, Shizuo Akira

Immunity　Vol. 37　No. 6　p. 1024-1036　2012/12/14　Research paper (scientific journal)

Origins and Properties of Dental, Thymic, and Bone Marrow Mesenchymal Cells and Their Stem Cells

Yukiya Komada, Toshiyuki Yamane, Daiji Kadota, Kana Isono, Nobuyuki Takakura, Shin-Ichi Hayashi, Hidetoshi Yamazaki

PLOS ONE　Vol. 7　No. 11　2012/11　Research paper (scientific journal)

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J. Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H. Adams, Nobuyuki Takakura, Yoh Takuwa

Nature Medicine　Vol. 18　No. 10　p. 1560-1569　2012/10　Research paper (scientific journal)

Monoclonal Antibody MS44 Against Mouse CD44

Nobuyuki Takakura

Hybridoma　Vol. 31　No. 4　2012/08/01　Research paper (scientific journal)

Monoclonal antibody selectively recognizing murine but not human CD44

Yumi Kinugasa, Nobuyuki Takakura

Hybridoma　Vol. 31　No. 4　p. 262-266　2012/08/01　Research paper (scientific journal)

Biology of the apelin-APJ axis in vascular formation

Hiroyasu Kidoya, Nobuyuki Takakura

JOURNAL OF BIOCHEMISTRY　Vol. 152　No. 2　p. 125-131　2012/08

The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy

H. Kidoya, N. Kunii, H. Naito, F. Muramatsu, Y. Okamoto, T. Nakayama, N. Takakura

Oncogene　Vol. 31　No. 27　p. 3254-3264　2012/07/05　Research paper (scientific journal)

A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice

Susumu Sakimoto, Hiroyasu Kidoya, Hisamichi Naito, Motohiro Kamei, Hirokazu Sakaguchi, Nobuhito Goda, Akiyoshi Fukamizu, Kohji Nishida, Nobuyuki Takakura

Development　Vol. 139　No. 7　p. 1327-1335　2012/04/01　Research paper (scientific journal)

Changes in blood vessel maturation in the fibrous cap of the tumor rim

Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroki Kawahara, Hiroyasu Kidoya, Nobuyuki Takakura

CANCER SCIENCE　Vol. 103　No. 3　p. 433-438　2012/03　Research paper (scientific journal)

Promotion of lymphatic integrity by angiopoietin-1/Tie2 signaling during inflammation

Kentaro Kajiya, Hiroyasu Kidoya, Mika Sawane, Yuuko Matsumoto-Okazaki, Haruyo Yamanishi, Mikio Furuse, Nobuyuki Takakura

American Journal of Pathology　Vol. 180　No. 3　p. 1273-1282　2012/03　Research paper (scientific journal)

Guest editorial: Mutual relationship between vascular biology and hematology

Nobuyuki Takakura

International Journal of Hematology　Vol. 95　No. 2　p. 117-118　2012/02　Research paper (scientific journal)

Involvement of non-vascular stem cells in blood vessel formation

Nobuyuki Takakura

INTERNATIONAL JOURNAL OF HEMATOLOGY　Vol. 95　No. 2　p. 138-142　2012/02　Research paper (scientific journal)

Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels

Hisamichi Naito, Hiroyasu Kidoya, Susumu Sakimoto, Taku Wakabayashi, Nobuyuki Takakura

EMBO JOURNAL　Vol. 31　No. 4　p. 842-855　2012/02　Research paper (scientific journal)

Formation and Regulation of niche for cancer stem cells

Takakura Nobuyuki

Drug Delivery System　Vol. 27　No. 1　p. 28-33　2012

Molecular analysis of Blood Vessel Maturation

TAKAKURA Nobuyuki

Blood & Vessel　Vol. 22　No. 6　p. 343-347　2011/12/01

Apelin Attenuates UVB-Induced Edema and Inflammation by Promoting Vessel Function

Mika Sawane, Hiroyasu Kidoya, Fumitaka Muramatsu, Nobuyuki Takakura, Kentaro Kajiya

AMERICAN JOURNAL OF PATHOLOGY　Vol. 179　No. 6　p. 2691-2697　2011/12　Research paper (scientific journal)

2-Methoxycinnamaldehyde inhibits tumor angiogenesis by suppressing Tie2 activation

Daishi Yamakawa, Hiroyasu Kidoya, Susumu Sakimoto, Weizhen Jia, Nobuyuki Takakura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 415　No. 1　p. 174-180　2011/11　Research paper (scientific journal)

Docking protein gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling

Wataru Shioyama, Yoshikazu Nakaoka, Kaori Higuchi, Takashi Minami, Yoshiaki Taniyama, Keigo Nishida, Hiroyasu Kidoya, Takashi Sonobe, Hisamichi Naito, Yoh Arita, Takahiro Hashimoto, Tadashi Kuroda, Yasushi Fujio, Mikiyasu Shirai, Nobuyuki Takakura, Ryuichi Morishita, Keiko Yamauchi-Takihara, Tatsuhiko Kodama, Toshio Hirano, Naoki Mochizuki, Issei Komuro

Circulation Research　Vol. 108　No. 6　p. 664-675　2011/03/18　Research paper (scientific journal)

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Keiichi Kumasawa, Masahito Ikawa, Hiroyasu Kidoya, Hidetoshi Hasuwa, Tomoko Saito-Fujita, Yuka Morioka, Nobuyuki Takakura, Tadashi Kimura, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America　Vol. 108　No. 4　p. 1451-1455　2011/01/25　Research paper (scientific journal)

Identification and functional analysis of endothelial tip cell-enriched genes

Raquel Del Toro, Claudia Prahst, Thomas Mathivet, Geraldine Siegfried, Joshua S. Kaminker, Bruno Larrivee, Christiane Breant, Antonio Duarte, Nobuyuki Takakura, Akiyoshi Fukamizu, Josef Penninger, Anne Eichmann

Blood　Vol. 116　No. 19　p. 4025-4033　2010/11/11　Research paper (scientific journal)

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-Ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-Kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura, Shuichi Kaneko

Cell Metabolism　Vol. 12　No. 5　p. 483-495　2010/11/03　Research paper (scientific journal)

Up-regulation of PSF1 promotes the growth of breast cancer cells

Izumi Nakahara, Mamiko Miyamoto, Tatsuhiro Shibata, Sadako Akashi-Tanaka, Takayuki Kinoshita, Kaoru Mogushi, Kohtaro Oda, Masaya Ueno, Nobuyuki Takakura, Hiroshi Mizushima, Hiroshi Tanaka, Tsutomu Ohta

Genes to Cells　Vol. 15　No. 10　p. 1015-1024　2010/10　Research paper (scientific journal)

Tumor and angiogenesis

TAKAKURA Nobuyuki

Blood & Vessel　Vol. 21　No. 3　p. 283-290　2010/06/01

Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia

Hiroyasu Kidoya, Hisamichi Naito, Nobuyuki Takakura

BLOOD　Vol. 115　No. 15　p. 3166-3174　2010/04　Research paper (scientific journal)

PSF3 marks malignant colon cancer and has a role in cancer cell proliferation

Yumi Nagahama, Masaya Ueno, Naotsugu Haraguchi, Masaki Mori, Nobuyuki Takakura

Biochemical and Biophysical Research Communications　Vol. 392　No. 2　p. 150-154　2010/02/05　Research paper (scientific journal)

PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties

Yumi Nagahama, Masaya Ueno, Satoru Miyamoto, Eiichi Morii, Takashi Minami, Naoki Mochizuki, Hideyuki Saya, Nobuyuki Takakura

Cancer Research　Vol. 70　No. 3　p. 1215-1224　2010/02/01　Research paper (scientific journal)

Lipid rafts serve as signaling platforms for Tie2 receptor tyrosine kinase in vascular endothelial cells

Shin-Ya Katoh, Takahiro Kamimoto, Daishi Yamakawa, Nobuyuki Takakura

EXPERIMENTAL CELL RESEARCH　Vol. 315　No. 16　p. 2818-2823　2009/10　Research paper (scientific journal)

Maturation of blood vessels by haematopoietic stem cells and progenitor cells: Involvement of apelin/APJ and angiopoietin/Tie2 interactions in vessel caliber size regulation

Nobuyuki Takakura, Hiroyasu Kidoya

THROMBOSIS AND HAEMOSTASIS　Vol. 101　No. 6　p. 999-1005　2009/06　Research paper (scientific journal)

Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population

Hisamichi Naito, Hiroyasu Kidoya, Yasufumi Sato, Nobuyuki Takakura

Journal of Biochemistry　Vol. 145　No. 5　p. 653-659　2009/05　Research paper (scientific journal)

Identification and characterization of stem cell-specific transcription of PSF1 in spermatogenesis

Yinglu Han, Masaya Ueno, Yumi Nagahama, Nobuyuki Takakura

Biochemical and Biophysical Research Communications　Vol. 380　No. 3　p. 609-613　2009/03/13　Research paper (scientific journal)

Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration

Masaya Ueno, Machiko Itoh, Kazushi Sugihara, Masahide Asano, Nobuyuki Takakura

Blood　Vol. 113　No. 3　p. 555-562　2009/01/15　Research paper (scientific journal)

Basic science of angiogenesis and its progress in clinical application

TAKAKURA Nobuyuki

Rinsho Ketsueki　Vol. 49　No. 10　p. 1451-1459　2008/10/30

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

Shigetomo Fukuhara, Keisuke Sako, Takashi Minami, Kazuomi Noda, Hak Zoo Kim, Tatsuhiko Kodama, Masabumi Shibuya, Nobuyuki Takakura, Gou Young Koh, Naoki Mochizuki

Nature Cell Biology　Vol. 10　No. 5　p. 513-526　2008/05　Research paper (scientific journal)

Involvement of MDR1 function in proliferation of tumour cells

Shin-Ya Katoh, Masaya Ueno, Nobuyuki Takakura

Journal of Biochemistry　Vol. 143　No. 4　p. 517-524　2008/04　Research paper (scientific journal)

Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis

Hiroyasu Kidoya, Masaya Ueno, Yoshihiro Yamada, Naoki Mochizuki, Mitsugu Nakata, Takashi Yano, Ryo Fujii, Nobuyuki Takakura

EMBO Journal　Vol. 27　No. 3　p. 522-534　2008/02/06　Research paper (scientific journal)

Angiopoietin-1 alters tumor growth by stabilizing blood vessels or by promoting angiogenesis

Naoyuki Satoh, Yoshihiro Yamada, Yumi Kinugasa, Nobuyuki Takakura

Cancer Science　Vol. 99　No. 12　p. 2373-2379　2008　Research paper (scientific journal)

Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death

Asuka Iwanaga, Tokiharu Sato, Kazushi Sugihara, Atsushi Hirao, Nobuyuki Takakura, Hiroshi Okamoto, Masahide Asano, Katsuji Yoshioka

NEUROSCIENCE LETTERS　Vol. 429　No. 1　p. 43-48　2007/12　Research paper (scientific journal)

EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis

Xiaoyong Huang, Yoshihiro Yamada, Hiroyasu Kidoya, Hisamichi Naito, Yumi Nagahama, Lingyu Kong, Shin-Ya Katoh, Weng-Lin Li, Masaya Ueno, Nobuyuki Takakura

Cancer Research　Vol. 67　No. 20　p. 9800-9808　2007/10/15　Research paper (scientific journal)

A novel approach for myocardial regeneration with educated cord blood cells cocultured with cells from brown adipose tissue

Yoshihiro Yamada, Shin-ichiro Yokoyama, Noboru Fukuda, Hiroyasu Kidoya, Xiao-Yong Huang, Hisamichi Naitoh, Naoyuki Satoh, Nobuyuki Takakura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 353　No. 1　p. 182-188　2007/02　Research paper (scientific journal)

Cardiac stem cells in brown adipose tissue express CD133 and induce bone marrow nonhematopoietic cells to differentiate into cardiomyocytes

Yoshihiro Yamada, Shin-Ichiro Yokoyama, Xiang-Di Wang, Noboru Fukuda, Nobuyuki Takakura

STEM CELLS　Vol. 25　No. 5　p. 1326-1333　2007　Research paper (scientific journal)

Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration

Yuko Ishida, Akihiko Kimura, Toshikazu Kondo, Takahito Hayashi, Masaya Ueno, Nobuyuki Takakura, Kouji Matsushima, Naofumi Mukaida

American Journal of Pathology　Vol. 170　No. 3　p. 843-854　2007　Research paper (scientific journal)

Negative regulation of VEGF-induced vascular leakage by blockade of angiotensin II type 1 receptor

Hideto Sano, Kohei Hosokawa, Hiroyasu Kidoya, Nobuyuki Takakura

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY　Vol. 26　No. 12　p. 2673-2680　2006/12　Research paper (scientific journal)

Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors

Yuka Sugimoto, Naoyuki Katayama, Masahiro Masuya, Eri Miyata, Masaya Ueno, Kohshi Ohishi, Kazuhiro Nishii, Nobuyuki Takakura, Hiroshi Shiku

British Journal of Haematology　Vol. 135　No. 5　p. 725-731　2006/12　Research paper (scientific journal)

Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation

Daisuke Nanba, Yumi Kinugasa, Chie Morimoto, Michiko Koizumi, Hisako Yamamura, Katsuhito Takahashi, Nobuyuki Takakura, Eisuke Mekada, Koji Hashimoto, Shigeki Higashiyama

Biochemical and Biophysical Research Communications　Vol. 350　No. 2　p. 315-321　2006/11/17　Research paper (scientific journal)

Roles of HIPK1 and HIPK2 in AML1-and p300-dependent transcription, hematopoiesis and blood vessel formation

Yukiko Aikawa, Lan Anh Nguyen, Kyoichi Isono, Nobuyuki Takakura, Yusuke Tagata, M. Lienhard Schmitz, Haruhiko Koseki, Issay Kitabayashi

EMBO JOURNAL　Vol. 25　No. 17　p. 3955-3965　2006/09　Research paper (scientific journal)

Platelet derived growth factor receptor alpha is essential for establishing a microenvironment that supports definitive erythropoiesis

Wen-Ling Li, Yoshihiro Yamada, Masaya Ueno, Satomi Nishikawa, Shin-Ichi Nishikawa, Nobuyuki Takakura

Journal of Biochemistry　Vol. 140　No. 2　p. 267-273　2006/08　Research paper (scientific journal)

Cardiac progenitor cells in brown adipose tissue repaired damaged myocardium

Y Yamada, XD Wang, SI Yokoyama, N Fukuda, N Takakura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 342　No. 2　p. 662-670　2006/04　Research paper (scientific journal)

Physiological pathway of differentiation of hematopoietic stem cell population into mural cells

Y Yamada, N Takakura

JOURNAL OF EXPERIMENTAL MEDICINE　Vol. 203　No. 4　p. 1055-1065　2006/04　Research paper (scientific journal)

Identification and characterization of mouse PSF1-binding protein, SLD5

Lingyu Kong, Masaya Ueno, Machiko Itoh, Katsuji Yoshioka, Nobuyuki Takakura

Biochemical and Biophysical Research Communications　Vol. 339　No. 4　p. 1204-1207　2006/01/27　Research paper (scientific journal)

PSF1 is essential for early embryogenesis in mice

Masaya Ueno, Machiko Itoh, Lingyu Kong, Kazushi Sugihara, Masahide Asano, Nobuyuki Takakura

Molecular and Cellular Biology　Vol. 25　No. 23　p. 10528-10532　2005/12　Research paper (scientific journal)

Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an epac-rap1 signaling pathway

S Fukuhara, A Sakurai, H Sano, A Yamagishi, S Somekawa, N Takakura, Y Saito, K Kangawa, N Mochizuki

MOLECULAR AND CELLULAR BIOLOGY　Vol. 25　No. 1　p. 136-146　2005/01　Research paper (scientific journal)

Angiogenesis : Regulation of angiogenesis by hematopoietic cells

TAKAKURA Nobuyuki

Ensho　Vol. 24　No. 5　p. 553-561　2004/09/25

NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors.

Sugita Y, Wada H, Fujita S, Nakata T, Sato S, Noguchi Y, Jungbluth AA, Yamaguchi M, Chen YT, Stockert E, Gnjatic S, Williamson B, Scanlan MJ, Ono T, Sakita I, Yasui M, Miyoshi Y, Tamaki Y, Matsuura N, Noguchi S, Old LJ, Nakayama E, Monden M

Cancer Res.　Vol. 64　No. 6　p. 2199-2204　2004/03　Research paper (scientific journal)

Defective smooth muscle development in qkl-deficient mice

ZH Li, N Takakura, Y Oike, T Imanaka, K Araki, T Suda, T Kaname, T Kondo, K Abel, K Yamamura

DEVELOPMENT GROWTH & DIFFERENTIATION　Vol. 45　No. 5-6　p. 449-462　2003/10　Research paper (scientific journal)

Roles of angiopoietin and TIE2 receptor angiogenesis

TAKAKURA Nobuyuki

Ensho　Vol. 21　No. 6　p. 615-623　2001/11/20

マウス網膜血管発生における血管壁細胞の役割

植村 明嘉, 平島 正則, 西川 伸一, 本田 孔士, 藤原 隆, 高倉 伸幸

日本眼科学会雑誌　Vol. 105　No. 臨増　p. 259-259　2001/03

Study on PDGF receptor beta pathway in glomerular formation in neonate mice

H Sano, M Yokode, N Takakura, G Takemura, T Doi, H Kataoka, T Sudo, S Nishikawa, H Fujiwara, SI Nishikawa, T Kita

ATHEROSCLEROSIS VI　Vol. 947　p. 303-305　2001　Research paper (scientific journal)

VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis

K Hamada, Y Oike, N Takakura, Y Ito, L Jussila, DJ Dumont, K Alitalo, T Suda

BLOOD　Vol. 96　No. 12　p. 3793-3800　2000/12　Research paper (scientific journal)

マウス網膜血管発生における血小板由来増殖因子の役割

植村 明嘉, 高木 均, 大谷 篤史, 王 英泰, 剣持 誠司, 小山 真治, 本田 孔士, 平島 正則, 西川 伸一, 高倉 伸幸

日本眼科学会雑誌　Vol. 104　No. 臨増　p. 237-237　2000/03

Distinct roles of platelet-derived growth factor receptors alpha and beta in atherogenesis in vivo: A study with antagonistic antibodies in apolipoprotein E deficient mice

Sano, H, Yokode, M, Sudo, T, Murayama, T, Kataoka, H, Takakura, N, Nishikawa, S, Nishikawa, SI, Kita, T

CIRCULATION　Vol. 100　No. 18　p. 742-742　1999/11/02

EXPRESSION OF MDR1 GENE IN CD7(+) ACUTE LYMPHOBLASTIC-LEUKEMIA CELLS

H MIWA, K KITA, K NISHII, N MORITA, N TAKAKURA, M FUKUMOTO, S SHIRAKAWA

MECHANISM AND NEW APPROACH ON DRUG RESISTANCE OF CANCER CELLS　Vol. 1026　p. 33-36　1993　Research paper (international conference proceedings)