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基本情報

研究

社会活動

その他の活動

森下 竜一

Morishita Ryuuichi

医学系研究科,寄附講座教授

keyword 分子生物学,循環器病学,老年病医学,内科学

学歴

  • ~ 1991年,大阪大学,医科学研究科,内科学
  • ~ 1991年,大阪大学
  • ~ 1987年,大阪大学,医学部,医学科
  • ~ 1987年,大阪大学

研究内容・専門分野

  • ライフサイエンス,循環器内科学
  • ライフサイエンス,内科学一般
  • ライフサイエンス,分子生物学

所属学会

  • アメリカ遺伝子治療学会
  • 循環器学会
  • 腎臓学会
  • 動脈硬化学会
  • アメリカ高血圧評議会
  • アメリカ循環器学会

論文

  • Upregulated expression of a subset of genes in APP ; ob / ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease,Mitsuru Shinohara,Masataka Kikuchi,Miyuki Onishi‐Takeya,Yoshitaka Tashiro,Kaoru Suzuki,Yasuhiro Noda,Shuko Takeda,Masahiro Mukouzono,Seiichi Nagano,Akio Fukumori,Ryuichi Morishita,Akihiro Nakaya,Naoyuki Sato,FASEB BioAdvances,Wiley,2021年03月02日,研究論文(学術雑誌)
  • A novel angiotensin II peptide vaccine without an adjuvant in mice.,Ryo Nakamaru,Hironori Nakagami,Hiroki Hayashi,Jiao Sun,Akiko Tenma,Koichi Yamamoto,Munehisa Shimamura,Ryuichi Morishita,Hiromi Rakugi,Journal of hypertension,Vol. 39,No. 1,p. 181-189,2021年01月,研究論文(学術雑誌)
  • Insight into the Role of Angiopoietins in Ageing-Associated Diseases.,Shin-Ichiro Hayashi,Hiromi Rakugi,Ryuichi Morishita,Cells,Vol. 9,No. 12,2020年12月08日,研究論文(学術雑誌)
  • Future Directions of Therapeutic Vaccines for Chronic Diseases.,Ryo Nakamaru,Hironori Nakagami,Hiromi Rakugi,Ryuichi Morishita,Circulation journal : official journal of the Japanese Circulation Society,Vol. 84,No. 11,p. 1895-1902,2020年10月23日,研究論文(学術雑誌)
  • 脊椎関節炎をターゲットとしたIL17Aワクチンの薬効の検討,林 宏樹,孫 嬌,柳田 結花,冨田 哲也,森下 竜一,中神 啓徳,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 20回,p. 240-240,2020年09月
  • 視線検出技術を用いたせん妄の定量的評価と発症予測,武田 朱公,大山 茜,中嶋 恒男,伊藤 祐規,鷹見 洋一,山本 浩一,杉本 研,竹屋 泰,樂木 宏実,森下 竜一,日本老年医学会雑誌,(一社)日本老年医学会,Vol. 57,No. Suppl.,p. 134-134,2020年07月
  • Therapeutic Angiogenesis Using HGF Plasmid,Fumihiro Sanada,Tatsuya Fujikawa,Kana Shibata,Yoshiaki Taniyama,Hiromi Rakugi,Ryuichi Morishita,Annals of Vascular Diseases,The Editorial Committee of Annals of Vascular Diseases,Vol. 13,No. 2,p. 109-115,2020年06月25日,研究論文(学術雑誌)
  • 覚醒・自由行動下におけるマウス脳脊髄液回収法の確立,武田 朱公,中嶋 恒男,大山 茜,伊藤 祐規,鷹見 洋一,竹屋 泰,山本 浩一,杉本 研,樂木 宏実,森下 竜一,日本老年医学会雑誌,(一社)日本老年医学会,Vol. 56,No. 4,p. 559-559,2019年10月
  • 高精度視線検出技術を用いた定量的認知機能評価法の開発,大山 茜,武田 朱公,伊藤 祐規,中嶋 恒男,鷹見 洋一,竹屋 泰,山本 浩一,杉本 研,樂木 宏実,森下 竜一,日本老年医学会雑誌,(一社)日本老年医学会,Vol. 56,No. 4,p. 563-563,2019年10月
  • 視線検出技術を用いた客観的かつ定量的なせん妄評価法の開発,武田 朱公,大山 茜,中嶋 恒男,伊藤 祐規,鷹見 洋一,山本 浩一,杉本 研,竹屋 泰,樂木 宏実,森下 竜一,Dementia Japan,(一社)日本認知症学会,Vol. 33,No. 4,p. 563-563,2019年10月
  • 【血管性認知症の新しい展開】血管性認知症と生活習慣病の病態新展開,武田 朱公,中嶋 恒男,森下 竜一,医学のあゆみ,医歯薬出版(株),Vol. 262,No. 3,p. 205-209,2017年07月
  • マウスにおける肝細胞増殖因子による肥満と糖代謝の恒常性障害からの保護(Protection from obesity and impaired glucose homeostasis by Hepatocyte growth factor in mice),岩林 正明,谷山 義明,東 純哉,家串 和真,眞田 文博,清水 一賢,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 13回,p. 199-199,2013年06月
  • ペリオスチン制御による急性心筋梗塞の治療法の開発,谷山 義明,葛城 鳴門,岡山 慶太,東 純哉,家串 和真,岩林 正明,清水 一賢,大津 礼,樂木 宏実,森下 竜一,Anti-aging Science,(株)メディカルレビュー社,Vol. 4,No. 3,p. 205-205,2012年11月
  • イルベサルタンの食塩感受性高血圧モデルに対する改善効果と肝細胞増殖因子(HGF)との関連,楠 博,谷山 義明,東 純哉,家串 和真,大津 礼,楽木 宏実,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 35回,p. 446-446,2012年09月
  • イルベサルタンの食塩感受性高血圧モデルに対する改善効果,楠 博,谷山 義明,東 純哉,家串 和真,岩林 正明,志水 秀郎,尾崎 和成,牧野 寛史,島村 宗尚,大津 礼,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 12回,p. 188-188,2012年06月
  • メタボリックシンドローム(MetS)病態モデルにおける肝細胞増殖因子(HGF),楠 博,谷山 義明,東 純哉,家串 和真,岩林 正明,志水 秀郎,尾崎 和成,大津 礼,牧野 寛史,島村 宗尚,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 12回,p. 189-189,2012年06月
  • 入院認知症患者における糖負荷後血中βアミロイド値測定,里 直行,武田 朱公,湯 久浩,守口 篤,楽木 宏実,森下 竜一,日本高血圧学会臨床高血圧フォーラムプログラム・抄録集,(NPO)日本高血圧学会,Vol. 1回,p. 147-147,2012年04月
  • 糖負荷後血中ベータ・アミロイド変動パターンのアルツハイマー病診断補助法としての有用性について,里 直行,武田 朱公,植田 茉莉,湯 久浩,守口 篤,樂木 宏実,森下 竜一,日本臨床分子医学会学術総会プログラム・抄録集,日本臨床分子医学会,Vol. 49回,p. 106-106,2012年04月
  • メタボリックシンドローム動物モデル(ApoEKO/HGF-Tg)における肝細胞増殖因子(HGF)による改善効果,楠 博,谷山 義明,東 純哉,大津 礼,家串 和真,楽木 宏実,森下 竜一,日本高血圧学会臨床高血圧フォーラムプログラム・抄録集,(NPO)日本高血圧学会,Vol. 1回,p. 123-123,2012年04月
  • イルベサルタンのPPARγ/HGF経路を介した腎保護効果-食塩感受性高血圧モデルによる検討,楠 博,谷山 義明,東 純哉,家串 和真,楽木 宏実,森下 竜一,日本高血圧学会臨床高血圧フォーラムプログラム・抄録集,(NPO)日本高血圧学会,Vol. 1回,p. 137-137,2012年04月
  • イルベサルタンのPPARγ/HGF経路によるメタボリックシンドローム病態の改善 ApoEKOマウスによる検討,楠 博,アマルナス・チャタジー,谷山 義明,東 純哉,家串 和真,楽木 宏実,森下 竜一,日本高血圧学会臨床高血圧フォーラムプログラム・抄録集,(NPO)日本高血圧学会,Vol. 1回,p. 137-137,2012年04月
  • テルミサルタンのPPARγ/HGF経路を介した腎保護作用,楠 博,谷山 義明,東 純哉,家串 和真,楽木 宏実,森下 竜一,日本高血圧学会臨床高血圧フォーラムプログラム・抄録集,(NPO)日本高血圧学会,Vol. 1回,p. 138-138,2012年04月
  • テルミサルタンの腎保護作用と肝細胞増殖因子(HGF)との関連,楠 博,谷山 義明,東 純哉,家串 和真,大津 礼,楽木 宏実,森下 竜一,日本臨床分子医学会学術総会プログラム・抄録集,日本臨床分子医学会,Vol. 49回,p. 99-99,2012年04月
  • 肝細胞増殖因子(HGF)のメタボリックシンドロームモデルでの抗炎症作用による改善効果,楠 博,谷山 義明,東 純哉,家串 和真,大津 礼,楽木 宏実,森下 竜一,日本臨床分子医学会学術総会プログラム・抄録集,日本臨床分子医学会,Vol. 49回,p. 109-109,2012年04月
  • The HGF/c-met receptor system under pathological conditions,Yoshiaki Taniyama,Junya Azuma,Kazuma Iekushi,Fumihiro Sanada,Masaaki Iwabayashi,Hiroshi Kusunoki,Keita Okayama,Rei Otsu,Hiromi Rakugi,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Bentham Science Publishers B.V.,Vol. 12,No. 2,p. 122-129,2012年,研究論文(学術雑誌)
  • 糖尿病がアルツハイマー病の後天的危険因子である機序,里 直行,武田 朱公,内尾 こずえ[山田],楽木 宏実,森下 竜一,臨床神経学,(一社)日本神経学会,Vol. 51,No. 12,p. 1324-1324,2011年12月
  • イルベサルタンの抗メタボリックシンドローム作用と肝細胞増殖因子との関連,アマルナス・チャタジー,谷山 義明,楠 博,東 純哉,家串 和真,眞田 文博,大津 礼,岩林 正明,岡山 慶太,楽木 宏実,森下 竜一,Anti-aging Science,(株)メディカルレビュー社,Vol. 3,No. Suppl.1,p. 322-322,2011年11月
  • 肝細胞増殖因子(HGF)の抗炎症効果によるメタボリックシンドローム病態への改善,楠 博,谷山 義明,東 純哉,大津 礼,岩林 正明,家串 和真,眞田 文博,アマルナス・チャタジー,岡山 慶太,楽木 宏実,森下 竜一,Anti-aging Science,(株)メディカルレビュー社,Vol. 3,No. Suppl.1,p. 322-322,2011年11月
  • イルベサルタンの臓器保護作用と肝細胞増殖因子(HGF) アルドステロン負荷モデルでの検討,大津 礼,谷山 義明,楠 博,東 純哉,家串 和真,眞田 文博,アマルナス・チャタジー,岩林 正明,岡山 慶太,楽木 宏実,森下 竜一,Anti-aging Science,(株)メディカルレビュー社,Vol. 3,No. Suppl.1,p. 328-328,2011年11月
  • 肝細胞増殖因子(HGF)によるPTEN/Akt経路抑制を介した腎保護作用,谷山 義明,家串 和真,東 純哉,楠 博,大津 礼,岩林 正明,清水 一賢,岡山 慶太,アマルナス・チャタジー,楽木 宏実,森下 竜一,Anti-aging Science,(株)メディカルレビュー社,Vol. 3,No. Suppl.1,p. 330-330,2011年11月
  • テルミサルタンのPPARγ/HGF経路を介した腎保護効果の検討,楠 博,谷山 義明,大津 礼,岩林 正明,東 純哉,家串 和真,眞田 文博,アマルナス・チャタジー,岡山 慶太,楽木 宏実,森下 竜一,Anti-aging Science,(株)メディカルレビュー社,Vol. 3,No. Suppl.1,p. 330-330,2011年11月
  • 肝細胞増殖因子(HGF)のメタボリックシンドローム(MetS)病態の改善効果,楠 博,谷山 義明,東 純哉,岩林 正明,アマルナット・チャッタッジー,大津 礼,家串 和真,真田 文博,岡山 慶太,楽木 宏実,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 34回,p. 419-419,2011年10月
  • 肝細胞増殖因子(HGF)はPTEN/Akt経路を介して腎臓線維化を抑制する,楠 博,谷山 義明,家串 和真,東 純哉,堂阪 宜雄,森下 竜一,楽木 宏実,日本老年医学会雑誌,(一社)日本老年医学会,Vol. 48,No. 4,p. 411-411,2011年07月
  • HGF(肝細胞増殖因子)はARBの腎保護作用のエフェクター分子である,楠 博,谷山 義明,家串 和真,真田 文博,東 純哉,岡山 慶太,岩林 正明,楽木 宏実,森下 竜一,日本腎臓学会誌,(一社)日本腎臓学会,Vol. 53,No. 3,p. 433-433,2011年05月
  • HGF(肝細胞増殖因子)はメタボサルタンの腎保護作用のエフェクター分子である,楠 博,谷山 義明,岩林 正明,家串 和真,大津 礼,清水 秀郎,島村 宗尚,尾崎 和成,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 11回,p. 259-259,2011年04月
  • ValsartanはAngiotensin II受容体非依存的にintegrin αVβ3を制御しLp(a)誘発性動脈硬化病変を抑制する,岩林 正明,谷山 義明,真田 文博,東 純哉,家串 和真,岡山 慶太,楠 博,清水 一賢,Chatterjee Amarnath,楽木 宏美,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 11回,p. 324-324,2011年04月
  • HGF(肝細胞増殖因子)はPPARγアゴニスト作用を持つARBの腎保護作用のエフェクター分子として発現する,楠 博,谷山 義明,家串 和真,眞田 文博,岡山 慶太,東 純哉,楽木 宏実,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 33回,p. 348-348,2010年10月
  • HGF(肝細胞増殖因子)はTGF-b1とアンジオテンシン2のクロストークをPTEN/Akt経路を介し、アンジオテンシン1型受容体(AT1R)の発現を抑制することで抑える,楠 博,谷山 義明,家串 和真,眞田 文博,東 純哉,岡山 慶太,楽木 宏実,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 33回,p. 348-348,2010年10月
  • 糖尿病合併アルツハイマー病モデルマウスにおける脳血管病態と脳内インスリンシグナルの変化,武田 朱公,里 直行,内尾 こずえ[山田],楽木 宏実,森下 竜一,Dementia Japan,(一社)日本認知症学会,Vol. 24,No. 3,p. 394-394,2010年09月
  • アミロイド・カスケード仮説を基に認知症は治るか? 認知症治療法開発の新機軸 アルツハイマー病と糖尿病の相互的病態修飾(Therapies based on the amyloid cascade hypothesis cure dementia? Innovation in dementia therapies Possible pathological interaction between diabetes mellitus and Alzheimer disease),里 直行,武田 朱公,内尾 こずえ[山田],楽木 宏実,森下 竜一,神経化学,日本神経化学会,Vol. 49,No. 2-3,p. 453-453,2010年08月
  • アルツハイマー病病態における血管性危険因子の役割 糖尿病合併アルツハイマー病モデルマウスの解析から(Role of vascular risk factors in the pathogenesis of Alzheimer disease: Analysis of novel mouse models of Alzheimer disease with diabetes),武田 朱公,里 直行,内尾 こずえ[山田],篠原 充,楽木 宏実,森下 竜一,神経化学,日本神経化学会,Vol. 49,No. 2-3,p. 486-486,2010年08月
  • 【認知症治療の今後を予測する】アルツハイマー病の遺伝子治療の今後,武田 朱公,里 直行,森下 竜一,医薬ジャーナル,(株)医薬ジャーナル社,Vol. 46,No. 5,p. 97-101,2010年05月
  • 糖尿病は脳血管障害と脳内インスリンシグナルの障害を介してアルツハイマー病脳内病態を修飾する,武田 朱公,里 直之,内尾 こずえ[山田],澤田 京子,國枝 孝典,篠原 充,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 10回,p. 161-161,2010年05月
  • 糖負荷による血中Aβの変動を利用した新たなアルツハイマー病診断指標の探索 全身糖代謝が血中Aβ濃度に与える影響の検討,武田 朱公,里 直之,内尾 こずえ[山田],澤田 京子,國枝 孝典,篠原 充,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 10回,p. 254-254,2010年05月
  • 肝細胞増殖因子(HGF)はPTEN/Akt経路を介し、腎臓線維化を抑制する,楠 博,谷山 義明,家串 和真,真田 文博,東 純哉,尾崎 和成,堂阪 宜雄,岡山 慶太,楽木 宏実,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 10回,p. 196-196,2010年05月
  • 【高血圧(第4版) 日本における最新の研究動向】基礎編 循環生理活性物質の最新知見 血管作動性物質 生合成、分泌、生理作用 肝細胞増殖因子(HGF)、血管内皮細胞増殖因子(VEGF),真田 文博,谷山 義明,家串 和真,森下 竜一,日本臨床,(株)日本臨床社,Vol. 67,No. 増刊6 高血圧(上),p. 283-287,2009年10月
  • HGFは筋線維芽細胞のアノイキスを誘発することで、腎臓における抗線維化作用を発揮する,楠 博,谷山 義明,家串 和真,東 純哉,堂阪 宜雄,真田 文博,鯉渕 信孝,楽木 宏実,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 32回,p. 274-274,2009年10月
  • アルツハイマー病と糖尿病の相互的な病態修飾機序の解明 新規病態合併モデル動物の作成とその解析,武田 朱公,里 直之,内尾 こずえ,澤田 京子,國枝 孝典,栗波 仁美,竹内 大亮,篠原 充,楽木 宏実,森下 竜一,Dementia Japan,(一社)日本認知症学会,Vol. 23,No. 2,p. 127-127,2009年08月
  • 血糖状態及び血中インスリン値は血中Aβ量を修飾する 血中Aβ値のアルツハイマー病バイオマーカーとしての最適化条件の検討,武田 朱公,里 直行,内尾 こずえ,澤田 京子,國枝 孝典,栗波 仁美,竹内 大亮,篠原 充,楽木 宏美,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 9回,p. 192-192,2009年04月
  • アルツハイマー病と糖尿病の相互的病態修飾機序の解明 新規病態合併モデル動物の作成とその解析,武田 朱公,里 直行,内尾 こずえ,澤田 京子,國枝 孝典,栗波 仁美,竹内 大亮,篠原 充,楽木 宏美,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 9回,p. 194-194,2009年04月
  • 【ACE阻害薬とARB どう使い分けるか】診る 循環系RASと組織RAS,谷山 義明,家串 和真,眞田 文博,武田 朱公,森下 竜一,Heart View,(株)メジカルビュー社,Vol. 13,No. 2,p. 132-139,2009年02月
  • EGFR degradationを介した肝細胞増殖因子(HGF)/c-Metシステムの抗老化、抗動脈硬化メカニズムの解明,眞田 文博,谷山 義明,家串 和真,森下 竜一,血管,日本心脈管作動物質学会,Vol. 32,No. 1,p. 15-15,2009年01月
  • 肝細胞増殖因子(HGF)による腎臓における筋線維芽細胞のアノイキスを介した直接的なTGF-β1抑制効果の解明,家串 和真,谷山 義明,東 純哉,真田 文博,堂阪 宣雄,楠 博,横井 豊彦,樂木 宏実,森下 竜一,日本高血圧学会総会プログラム・抄録集,(NPO)日本高血圧学会,Vol. 31回,p. 304-304,2008年10月
  • マウス圧負荷心肥大モデルを用いた肝細胞増殖因子の抗線維化作用の検討,堂阪 宜雄,谷山 義明,東 純哉,家串 和真,楽木 宏実,森下 竜一,Circulation Journal,(一社)日本循環器学会,Vol. 72,No. Suppl.III,p. 1111-1111,2008年10月
  • 【閉塞性動脈硬化症 治療戦略の変化と進歩】先進医療 末梢動脈閉塞性疾患に対する再生医療 遺伝子治療,谷山 義明,東 純哉,家串 和真,眞田 文博,堂阪 宜雄,楠 博,清水 一賢,森下 竜一,カレントテラピー,(株)ライフメディコム,Vol. 26,No. 9,p. 801-805,2008年09月
  • 血管内皮成長因子ではなく肝細胞成長因子はEPCのアンジオテンシンII誘発性老化を減弱化させる(Hepatocyte Growth Factor, but not Vascular Endothelial Growth Factor, Attenuated Ang II-induced Senescence in EPC),谷山 義明,眞田 文博,家串 和真,堂阪 宜雄,森下 竜一,日本抗加齢医学会総会プログラム・抄録集,(一社)日本抗加齢医学会,Vol. 8回,p. 203-203,2008年06月
  • 肝細胞増殖因子はrac1の活性化を抑制することによりアンジオテンシンIIによる血管内皮細胞の老化を抑制する,眞田 文博,谷山 義明,家串 和真,堂坂 宣夫,森下 竜一,脈管学,(一社)日本脈管学会,Vol. 47,No. Suppl.,p. S104-S104,2007年09月
  • 肝細胞増殖因子(HGF)と血管内皮細胞増殖因子(VEGF)による血管内皮前駆細胞(EPC)への抗酸化・抗老化作用の比較 GTP結合rac1への効果の相違,眞田 文博,谷山 義明,家串 和真,堂坂 宜雄,相澤 義房,森下 竜一,日本内分泌学会雑誌,(一社)日本内分泌学会,Vol. 83,No. 2,p. 590-590,2007年09月
  • [Therapeutic angiogenesis for ischemic heart disease induced by gene transfer].,Yoshiaki Taniyama,Ryuichi Morishita,Junya Azuma,Kazuma Iekushi,Nihon rinsho. Japanese journal of clinical medicine,Vol. 63 Suppl 12,p. 588-93,2005年12月,研究論文(学術雑誌)
  • [Gene therapy for diabetic microangiopathy].,Yoshiaki Taniyama,Ryuichi Morishita,Junya Azuma,Kazuma Iekushi,Toshio Ogihara,Nihon rinsho. Japanese journal of clinical medicine,Vol. 63 Suppl 6,p. 153-8,2005年06月,研究論文(学術雑誌)
  • Modification of plasmid DNA-based gene transfer into central nerve system,Yoshiaki Taniyama,Munehisa Shimamura,Naoyuki Sato,Naruya Tomita,Masayuki Endho,Junya Azuma,Kazuma Iekushi,Yasufumi Kaneda,Toshio Ogihara,Ryuichi Morishita,International Congress Series,Vol. 1274,No. C,p. 159-163,2004年10月01日,研究論文(学術雑誌)
  • 高齢者閉塞性動脈硬化症に対するHGF遺伝子プラスミドを用いた血管新生療法の検討,若山 幸示,森下 竜一,青木 元邦,山崎 慶太,牧野 寛史,橋弥 尚孝,東 純哉,村上 和司,金田 安史,荻原 俊男,日本老年医学会雑誌,(一社)日本老年医学会,Vol. 39,No. Suppl.,p. 89-89,2002年05月
  • Decoy oligodeoxynucleotides as novel cardiovascular drugs for cardiovascular disease,R Morishita,M Aoki,Y Kaneda,ATHEROSCLEROSIS VI,NEW YORK ACAD SCIENCES,Vol. 947,p. 294-302,2001年,研究論文(学術雑誌)
  • Transcription factor decoy for NF kappa B inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis,T Tomita,H Takano,H Tomita,R Morishita,M Kaneko,K Shi,K Takahi,T Nakase,Y Kaneda,H Yoshikawa,T Ochi,RHEUMATOLOGY,OXFORD UNIV PRESS,Vol. 39,No. 7,p. 749-757,2000年07月,研究論文(学術雑誌)
  • Contribution of a vascular modulator, hepatocyte growth factor (HGF), to the pathogenesis of cardiovascular disease.,R Morishita,S Nakamura,S Hayashi,M Aoki,H Matsushita,N Tomita,K Yamamoto,A Moriguchi,J Higaki,T Ogihara,Journal of atherosclerosis and thrombosis,Vol. 4,No. 3,p. 128-34,1998年,研究論文(学術雑誌)
  • Potential role of a novel vascular modulator, hepatocyte growth factor (HGF), in cardiovascular disease: characterization and regulation of local HGF system.,R Morishita,M Aoki,S Nakamura,H Matsushita,N Tomita,S Hayashi,A Moriguchi,K Matsumoto,T Nakamura,J Higaki,T Ogihara,Journal of atherosclerosis and thrombosis,Vol. 4,No. 1,p. 12-9,1997年,研究論文(学術雑誌)

MISC

  • 血管性認知症と生活習慣病の病態新展開 (特集 血管性認知症の新しい展開),武田 朱公,中嶋 恒男,森下 竜一,医学のあゆみ,医歯薬出版,Vol. 262,No. 3,p. 205-209,2017年07月15日
  • S100A9タンパク質を標的とした新規抗血栓ワクチンによる脳梗塞予防法の開発,河野友裕,島村宗尚,中神啓徳,郡山弘,佐々木勉,森下竜一,望月秀樹,Anti-Aging Science,Vol. 9,No. 2,2017年
  • Therapeutic Application of an Angiotensin II Peptide Vaccine in a Middle Cerebral Artery Occlusion Model in Rats,Kouji Wakayama,Munehisa Shimamura,Jun-ichi Suzuki,Mitsuaki Isobe,Hironori Nakagami,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 47,2016年02月,研究発表ペーパー・要旨(国際会議)
  • PDE3 Inhibitor, Cilostazol, Ameliorates Ischemic Hindlimb Through cAMP and PPAR gamma Activation,Fumihiro Sanada,Yoshiaki Taniyama,Jyun Muratsu,Yuka Ikeda-Iwabu,Rei Otsu,Hiromi Rakugi,Ryuichi Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 132,2015年11月,研究発表ペーパー・要旨(国際会議)
  • DEVELOPMENT OF DNA VACCINE FOR HIGH BLOOD PRESSURE - IMMUNOTHERPY FOR ANGIOTENSIN II.,Hironori Nakagami,Ryuichi Morishita,Yasufumi Kaneda,JOURNAL OF GENE MEDICINE,WILEY-BLACKWELL,Vol. 16,No. 7-8,p. 255-255,2014年07月,研究発表ペーパー・要旨(国際会議)
  • Potential Contribution of RANKL System in Adipose Tissue Inflammation and Insulin Resistance,Mariana K. Osako,Futoshi Nakagami,Hironori Nakagami,Ryuichi Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 126,No. 21,2012年11月,研究発表ペーパー・要旨(国際会議)
  • Role of Serotonin in Angiogenesis: Induction of Angiogenesis by Sarpogrelate via Endothelial 5-HT1B/Akt/eNOS Pathway in Diabetic Mice,Masaaki Iwabayashi,Yoshiaki Taniyama,Fumihiro Sanada,Junya Azuma,Kazuma Iekushi,Hiroshi Kusunoki,Amarnath Chatterjee,Keita Okayama,Hiromi Rakugi,Ryuichi Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 124,No. 21,2011年11月,研究発表ペーパー・要旨(国際会議)
  • HGF as Angiogenic Factor and Therapeutic Approach,Yoshiaki Taniyama,Yasushi Takeya,Junya Azuma,Kazuma Iekushi,Fumihiro Sanada,Hiroshi Kusunoki,Keita Okayama,Nobutaka Koibuchi,Hiromi Rakugi,Ryuichi Morishita,CURRENT SIGNAL TRANSDUCTION THERAPY,BENTHAM SCIENCE PUBL LTD,Vol. 6,No. 2,p. 221-227,2011年05月,書評論文,書評,文献紹介等
  • NEUTRALIZED ANTIBODY AGAINST PERIOSTIN 1 IMPROVED CARDIAC DYSFUNCTION IN RAT ACUTE MYOCARDIAL INFARCTION MODEL: PERIOSTIN-1 AS A NOVEL THERAPEUTIC TARGET FOR HEART FAILURE,Yoshiaki Taniyama,Junya Azuma,Kazuma Iekushi,Fumihiro Sanada,Norio Dosaka,Hiroshi Kusunoki,Keita Okayama,Hiromi Rakugi,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 12,No. 12,p. 1050-1050,2010年12月,研究発表ペーパー・要旨(国際会議)
  • HEPATOCYTE GROWTH FACTOR ATTENUATES TGF-beta 1 ANGIOTENSIN II CROSSTALK BY DOWN REGULATION OF ANGIOTENSIN II TYPE 1 RECEPTOR THROUGH PTEN UPREGULATION,Hiroshi Kusunoki,Yoshiaki Taniyama,Kazuma Iekushi,Junya Azuma,Fumihiro Sanada,Norio Dosaka,Toyohiko Yokoi,Nobutaka Koibuchi,Mariko Kyutoku,Hiromi Rakugi,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 12,No. 12,p. 1026-1026,2010年12月,研究発表ペーパー・要旨(国際会議)
  • ULTRASOUND-MEDIATED GENE TRANSFER OF HGF IMPROVED ABETA-INDUCED COGNITIVE IMPAIRMENT IN MICE ASSOCIATED WITH UPREGULATION OF BDNF, AND DOWNREGULATION OF OXIDATIVE STRESS.,Daisuke Takeuchi,Naoyuki Sato,Hitomi Kurinami,Munehisa Shimamura,Shuko Takeda,Mitsuru Shinohara,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 12,No. 12,p. 1048-1049,2010年12月,研究発表ペーパー・要旨(国際会議)
  • "Estrogen Prevents Aortic Calcification by inducing MGP Expression and Inhibiting BMP Expression in an Estrogen Receptor alpha Dependent Way,Mariana K. Osako,Hironori Nakagami,Hiromi Rakugi,Ryuichi Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 122,No. 21,2010年11月,研究発表ペーパー・要旨(国際会議)
  • アルツハイマー病の遺伝子治療の今後 (特集 認知症治療の今後を予測する),武田 朱公,里 直行,森下 竜一,医薬ジャ-ナル,医薬ジャ-ナル社,Vol. 46,No. 5,p. 97-101,2010年05月
  • Role of vascular risk factors in the pathogenesis of Alzheimer disease: Analysis of novel mouse models of Alzheimer disease with diabetes,Shuko Takeda,Naoyuki Sato,Kozue Uchio-Yamada,Mitsuru Shinohara,Hiromi Rakugi,Ryuichi Morishita,NEUROSCIENCE RESEARCH,ELSEVIER IRELAND LTD,Vol. 68,p. E68-E68,2010年,研究発表ペーパー・要旨(国際会議)
  • ANALYSIS OF DE NOVO ENGINEERED VARIANTS OF AG-30 FOR THE TREATMENT OF ISCHEMIC DISEASES AND INFECTIOUS DISEASES,Tomoyuki Nishikawa,Hironori Nakagami,Ryuichi Morishita,Akito Maeda,Katsuto Tamai,Kazunori Tomono,Yasufumi Kaneda,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 11,No. 12,p. 1166-1167,2009年12月,研究発表ペーパー・要旨(国際会議)
  • Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Futoshi Nakagami,Yasuo Kunugiza,Tetsuya Tomita,Hideki Yoshikawa,Hiromi Rakugi,Toshio Ogihara,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 32,No. 9,p. 786-790,2009年09月
  • Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Futoshi Nakagami,Yasuo Kunugiza,Tetsuya Tomita,Hideki Yoshikawa,Hiromi Rakugi,Toshio Ogihara,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 32,No. 9,p. 786-790,2009年09月
  • Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Futoshi Nakagami,Yasuo Kunugiza,Tetsuya Tomita,Hideki Yoshikawa,Hiromi Rakugi,Toshio Ogihara,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 32,No. 9,p. 786-790,2009年09月
  • Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Futoshi Nakagami,Yasuo Kunugiza,Tetsuya Tomita,Hideki Yoshikawa,Hiromi Rakugi,Toshio Ogihara,Ryuichi Morishita,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 32,No. 9,p. 786-790,2009年09月
  • Pharmacological treatment of abdominal aortic aneurysm,Takashi Miyake,Ryuichi Morishita,CARDIOVASCULAR RESEARCH,OXFORD UNIV PRESS,Vol. 83,No. 3,p. 436-443,2009年08月,書評論文,書評,文献紹介等
  • Genetic basis of hypertension for the development of tailored medicine,Tomohiro Katsuya,Ryuichi Morishita,Hiromi Rakugi,Toshio Ogihrara,HYPERTENSION RESEARCH,NATURE PUBLISHING GROUP,Vol. 32,No. 8,p. 643-648,2009年08月,書評論文,書評,文献紹介等
  • Validation of A beta 1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease,Shuko Takeda,Naoyuki Sato,Kazue Niisato,Daisuke Takeuchi,Hitomi Kurinami,Mitsuru Shinohara,Hiromi Rakugi,Masanobu Kano,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1280,p. 137-147,2009年07月
  • Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models,Shuko Takeda,Naoyuki Sato,Kozue Uchio-Yamada,Kyoko Sawada,Takanori Kunieda,Daisuke Takeuchi,Hitomi Kurinami,Mitsuru Shinohara,Hiromi Rakugi,Ryuichi Morishita,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 385,No. 2,p. 193-197,2009年07月
  • Validation of A beta 1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease,Shuko Takeda,Naoyuki Sato,Kazue Niisato,Daisuke Takeuchi,Hitomi Kurinami,Mitsuru Shinohara,Hiromi Rakugi,Masanobu Kano,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1280,p. 137-147,2009年07月
  • Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models,Shuko Takeda,Naoyuki Sato,Kozue Uchio-Yamada,Kyoko Sawada,Takanori Kunieda,Daisuke Takeuchi,Hitomi Kurinami,Mitsuru Shinohara,Hiromi Rakugi,Ryuichi Morishita,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 385,No. 2,p. 193-197,2009年07月
  • Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action,Rie Hanayam,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Hirofumi Makino,Yasuo Kunugiza,Tetsuya Tomita,Ikuyo Tsukamoto,Hideki Yoshikawa,Hiromi Rakugi,Ryuchi Morishita,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,SPANDIDOS PUBL LTD,Vol. 23,No. 5,p. 581-588,2009年05月
  • Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action,Rie Hanayam,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Hirofumi Makino,Yasuo Kunugiza,Tetsuya Tomita,Ikuyo Tsukamoto,Hideki Yoshikawa,Hiromi Rakugi,Ryuchi Morishita,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,SPANDIDOS PUBL LTD,Vol. 23,No. 5,p. 581-588,2009年05月
  • Vascular protective effects of ezetimibe in ApoE-deficient mice,Hironori Nakagami,Mariana Kiomy Osako,Yoichi Takami,Rie Hanayama,Hiroshi Koriyama,Masaki Mori,Hiroki Hayashi,Hideo Shimizu,Ryuichi Morishita,ATHEROSCLEROSIS,ELSEVIER IRELAND LTD,Vol. 203,No. 1,p. 51-58,2009年03月
  • Vascular protective effects of ezetimibe in ApoE-deficient mice,Hironori Nakagami,Mariana Kiomy Osako,Yoichi Takami,Rie Hanayama,Hiroshi Koriyama,Masaki Mori,Hiroki Hayashi,Hideo Shimizu,Ryuichi Morishita,ATHEROSCLEROSIS,ELSEVIER IRELAND LTD,Vol. 203,No. 1,p. 51-58,2009年03月
  • Hepatocyte Growth Factor, but not Vascular Endothelial Growth Factor, Attenuates Angiotensin II-Induced Endothelial Progenitor Cell Senescence,Fumihiro Sanada,Yoshiaki Taniyama,Junya Azuma,Kazuma Iekushi,Norio Dosaka,Toyohiko Yokoi,Nobutaka Koibuchi,Hiroshi Kusunoki,Yoshifusa Aizawa,Ryuichi Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 53,No. 1,p. 77-U137,2009年01月
  • Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration,Suguru Shiraya,Takashi Miyake,Motokum Aoki,Fujiwara Yoshikazu,Shigetsugu Ohgi,Motonobu Nishimura,Toshio Ogihara,Ryuichi Morishita,ATHEROSCLEROSIS,ELSEVIER IRELAND LTD,Vol. 202,No. 1,p. 34-40,2009年01月
  • Injection of HGF plasmid cDNA to prevent manifestation of Parkinson disease: A preclinical study using a primate model,Hiromi Koike,Akihiko Ishida,Takuya Hayashi,Munehisa Shimamura,Shinya Mizuno,Toshikazu Nakamura,Hidehiro Iida,Toshio Ogihara,Yasufumi Kaneda,Ryuichi Morishita,Open Gene Therapy Journal,Vol. 2,p. 38-44,2009年
  • Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin II-induced,Vol. 53(1);77-82,2009年
  • Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin,Vol. 202(1);34-40,2009年
  • Genetic basis of hypertension for the development of tailored medicine.,Hypertens Res,Vol. 32(8): 643-648,2009年
  • Injection of HGF plasmid cDNA to prevent manifestation of Parkinson disease: A preclinical study using a primate model,Hiromi Koike,Akihiko Ishida,Takuya Hayashi,Munehisa Shimamura,Shinya Mizuno,Toshikazu Nakamura,Hidehiro Iida,Toshio Ogihara,Yasufumi Kaneda,Ryuichi Morishita,Open Gene Therapy Journal,Vol. 2,p. 38-44,2009年
  • Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan,Yoshikazu Fujiwara,Suguru Shiraya,Takashi Miyake,Satoshi Yamakawa,Motokuni Aoki,Hirofumi Makino,Motonobu Nishimura,Ryuichi Morishita,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,SPANDIDOS PUBL LTD,Vol. 22,No. 6,p. 703-708,2008年12月
  • Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan,Yoshikazu Fujiwara,Suguru Shiraya,Takashi Miyake,Satoshi Yamakawa,Motokuni Aoki,Hirofumi Makino,Motonobu Nishimura,Ryuichi Morishita,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,SPANDIDOS PUBL LTD,Vol. 22,No. 6,p. 703-708,2008年12月
  • Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NF kappa B and E2F in a rabbit model,Takashi Miyake,Motokuni Aoki,Ryuichi Morishita,CARDIOVASCULAR RESEARCH,OXFORD UNIV PRESS,Vol. 79,No. 4,p. 706-714,2008年09月
  • Long-term follow up of initial clinical cases with NFκB decoy oligodeoxynucleotide transfection at the site of coronary stenting,THE JOURNAL OF GENE MEDICINE,Vol. 10,No. 7,p. 805-809,2008年07月
  • Angiotensin II accelerates osteoporosis by activating osteoclasts,Hideo Shimizu,Hironori Nakagami,Mariana Kiomy Osako,Rie Hanayama,Yasuo Kunugiza,Takuji Kizawa,Tetsuya Tomita,Hideki Yoshikawa,Toshio Ogihara,Ryuichi Morishita,FASEB JOURNAL,FEDERATION AMER SOC EXP BIOL,Vol. 22,No. 7,p. 2465-2475,2008年07月
  • Pleiotropic effect of statins as antioxidants on cardiac hypertrophy,Hironori Nakagami,Ryuichi Morishita,Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry,Vol. 8,No. 2,p. 167-171,2008年06月
  • Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model.,Gene Therapy,Vol. 15,No. 8,p. 561-571,2008年04月
  • Potential role of CYLD (cylindromatosis) as a deubiquitinating enzyme in vascular cells,Yoichi Takami,Hironori Nakagami,Ryuichi Morishita,Tomohiro Katsuya,Hiroki Hayashi,Masaki Mori,Hiroshi Koriyama,Yoshichika Baba,Osamu Yasuda,Hiromi Rakugi,Toshio Ogihara,Yasufumi Kaneda,AMERICAN JOURNAL OF PATHOLOGY,AMER SOC INVESTIGATIVE PATHOLOGY, INC,Vol. 172,No. 3,p. 818-829,2008年03月
  • Potential role of CYLD (cylindromatosis) as a deubiquitinating enzyme in vascular cells,Yoichi Takami,Hironori Nakagami,Ryuichi Morishita,Tomohiro Katsuya,Hiroki Hayashi,Masaki Mori,Hiroshi Koriyama,Yoshichika Baba,Osamu Yasuda,Hiromi Rakugi,Toshio Ogihara,Yasufumi Kaneda,AMERICAN JOURNAL OF PATHOLOGY,AMER SOC INVESTIGATIVE PATHOLOGY, INC,Vol. 172,No. 3,p. 818-829,2008年03月
  • Therapeutic potential of ribbon type oligodeoxynucleotide decoy NF-kappa B in cardiovascular diseases,Mariana K. Osako,Naruya Tomita,Hironori Nakagami,Ryuichi Morishita,JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,Vol. 44,No. 2,p. 443-443,2008年02月,研究発表ペーパー・要旨(国際会議)
  • Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stress in amyloid β injection mouse model.,International Journal of Molecular Medicine,Vol. 21,2008年
  • Differential response of vascular hepatocyte growth factor concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice,Molecular Medicine Reports,Vol. 1,2008年
  • E2F as therapeutic target using decoy strategy,Control of cellular Physiology,2008年
  • A model of cerebrovascular injury in rats.,J Neurosci Methods,Vol. 175(2),2008年
  • The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new thrapeutic potential.,Frontiers in Bioscience,Vol. 13:2253-2265,2008年
  • The renin-angiotensin system, hypertension and cognitive dysfunction in Alzheimer's disease: new thrapeutic potential.,Frontiers in Bioscience,Vol. 13:2253-2265,2008年
  • Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase,Aya Nakagawa,Hirofumi Makino,Motokuni Aoki,Takashi Miyake,Suguru Shiraya,Toshikazu Nakamura,Toshio Ogihara,Yoshihiro Kimata,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 9,No. 12,p. 1087-1094,2007年12月
  • Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats,Munehisa Shimamura,Naoyuki Sato,Masataka Sata,Hitomi Kurinami,Daisuke Takeuchi,Kouji Wakayama,Takuya Hayashi,Hidehiro Iida,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 38,No. 12,p. 3251-3258,2007年12月
  • Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats,Munehisa Shimamura,Naoyuki Sato,Masataka Sata,Hitomi Kurinami,Daisuke Takeuchi,Kouji Wakayama,Takuya Hayashi,Hidehiro Iida,Ryuichi Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 38,No. 12,p. 3251-3258,2007年12月
  • Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase,Aya Nakagawa,Hirofumi Makino,Motokuni Aoki,Takashi Miyake,Suguru Shiraya,Toshikazu Nakamura,Toshio Ogihara,Yoshihiro Kimata,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 9,No. 12,p. 1087-1094,2007年12月
  • Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappa B and ets in a rabbit model,Takashi Miyake,Motokuni Aoki,Hisao Masaki,Tomio Kawasaki,Masako Oishi,Kazusaburo Kataoka,Toshio Ogihara,Yasufumi Kaneda,Ryuichi Morishita,CIRCULATION RESEARCH,LIPPINCOTT WILLIAMS & WILKINS,Vol. 101,No. 11,p. 1175-1184,2007年11月
  • Involvement of γ-secretase in postnatal angiogenesis.,Biochemical and Biophysical Research Communications,Vol. 363,No. 3,p. 584-590,2007年11月
  • Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappa B and ets in a rabbit model,Takashi Miyake,Motokuni Aoki,Hisao Masaki,Tomio Kawasaki,Masako Oishi,Kazusaburo Kataoka,Toshio Ogihara,Yasufumi Kaneda,Ryuichi Morishita,CIRCULATION RESEARCH,LIPPINCOTT WILLIAMS & WILKINS,Vol. 101,No. 11,p. 1175-1184,2007年11月
  • Involvement of gamma-secretase in postnatal angiogenesis,Hiroki Hayashi,Hironori Nakagami,Yoichi Takami,Naoyuki Sato,Yukihiro Saito,Tomoyuki Nishikawa,Masaki Mori,Hiroshi Koriyama,Katsuto Tamai,Ryuichi Morishita,Yasufumi Kaneda,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 363,No. 3,p. 584-590,2007年11月
  • Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappa B activation,Yoichi Takami,Hironori Nakagami,Ryuichi Morishita,Tomohiro Katsuya,Tai-Xing Cui,Tomonaga Ichikawa,Yukihiro Saito,Hiroki Hayashi,Yasushi Kikuchi,Tomoyuki Nishikawa,Yoshichika Baba,Osamu Yasuda,Hiromi Rakugi,Toshio Ogihara,Yasufumi Kaneda,ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 27,No. 10,p. 2184-2190,2007年10月
  • Increase in nuclease resistance and incorporation of NF-κB decoy oligodeoxynucleotides by modification of the 3'-terminus.,The Journal of Gene Medicine,Vol. 9,No. 9,p. 812-819,2007年09月
  • Increase in nuclease resistance and incorporation of NF-kappa B decoy oligodeoxynucteotides by modification of the 3 '-terminus,Mariana Kiomy Osako,Naruya Abstract Tomita,Hironori Nakagami,Yasuo Kunugiza,Masafumi Yoshino,Kazuhiko Yuyama,Tetsuya Tomita,Hideki Be Specific To The Target Transcription Fac,Toshio Ogihara,Ryuichi Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 9,No. 9,p. 812-819,2007年09月
  • Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus,Kaori Nagao,Yoshiaki Taniyama,Nobutaka Koibuchi,Ryuichi Morishita,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 359,No. 3,p. 431-437,2007年08月
  • Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus,Kaori Nagao,Yoshiaki Taniyama,Nobutaka Koibuchi,Ryuichi Morishita,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 359,No. 3,p. 431-437,2007年08月
  • Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats,Munehisa Shimamura,Naoyuki Sato,Masataka Sata,Kouji Wakayama,Toshio Ogihara,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1151,p. 188-194,2007年06月
  • Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats,Munehisa Shimamura,Naoyuki Sato,Masataka Sata,Kouji Wakayama,Toshio Ogihara,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1151,p. 188-194,2007年06月
  • Potential contribution of action of renin angiotensin system to bone metabolism,Hironori Nakagami,Mariana Kiomy Osaka,Hideo Shimizu,Rie Hanayama,Ryuichi Morishita,Current Hypertension Reviews,Vol. 3,No. 2,p. 129-132,2007年05月,書評論文,書評,文献紹介等
  • Potential contribution of action of renin angiotensin system to bone metabolism,Hironori Nakagami,Mariana Kiomy Osaka,Hideo Shimizu,Rie Hanayama,Ryuichi Morishita,Current Hypertension Reviews,Vol. 3,No. 2,p. 129-132,2007年05月,書評論文,書評,文献紹介等
  • Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats,Kouji Wakayama,Munehisa Shimamura,Masataka Sata,Naoyuki Sato,Koji Kawakami,Hirotsugu Fukuda,Takuji Tomimatsu,Toshio Ogihara,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1130,No. 1,p. 181-187,2007年01月
  • Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats.,Int J Mol Med.,Vol. 19(4);571-9,2007年
  • Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin.,Hypertension,Vol. 49(6);1409-14.,2007年
  • Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.,Arterioscler Thromb Vasc Biol.,Vol. 27(10):2184-90.,2007年
  • Gene Polymorphism of Myospryn (Coardiomyopathy-Associated 5) Is Associated with Left Ventricular Wall Thickness in Patients with Hypertension.,Hypertension Research,Vol. 30(12):1239-1246,2007年
  • Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats,Kouji Wakayama,Munehisa Shimamura,Masataka Sata,Naoyuki Sato,Koji Kawakami,Hirotsugu Fukuda,Takuji Tomimatsu,Toshio Ogihara,Ryuichi Morishita,BRAIN RESEARCH,ELSEVIER SCIENCE BV,Vol. 1130,No. 1,p. 181-187,2007年01月
  • Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats.,Int J Mol Med.,Vol. 19(4);571-9,2007年
  • Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin.,Hypertension,Vol. 49(6);1409-14.,2007年
  • Gene Polymorphism of Myospryn (Coardiomyopathy-Associated 5) Is Associated with Left Ventricular Wall Thickness in Patients with Hypertension.,Hypertension Research,Vol. 30(12):1239-1246,2007年
  • New mechanisms of an angiotensin receptor blocker, valsartan, on the heart failure through the inhibition of novel anti-adhesion molecule, periostin,Kazuma Iekushi,Yoshiaki Taniyama,Junya Azuma,Norio Dosaka,Toshio Ogihara,Ryuichi Morishita,JOURNAL OF HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 24,p. 374-374,2006年12月,研究発表ペーパー・要旨(国際会議)
  • Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease,H. Koike,A. Ishida,M. Shimamura,S. Mizuno,T. Nakamura,T. Ogihara,Y. Kaneda,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 23,p. 1639-1644,2006年12月
  • Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease,H. Koike,A. Ishida,M. Shimamura,S. Mizuno,T. Nakamura,T. Ogihara,Y. Kaneda,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 23,p. 1639-1644,2006年12月
  • Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappa B and ets,Suguru Shiraya,Ken Miwa,Motokuni Aoki,Takashi Miyake,Masako Oishi,Kazusaburo Kataoka,Shigetsup Ohgi,Toshio Ogihara,Yasufutni Kaneda,Ryuichi Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 48,No. 4,p. 628-636,2006年10月
  • Hypertension accelerated experimental abdominal aortic aneurysm through upregulation of nuclear factor kappa B and ets,Suguru Shiraya,Ken Miwa,Motokuni Aoki,Takashi Miyake,Masako Oishi,Kazusaburo Kataoka,Shigetsup Ohgi,Toshio Ogihara,Yasufutni Kaneda,Ryuichi Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 48,No. 4,p. 628-636,2006年10月
  • Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy,J. Azuma,Y. Taniyama,Y. Takeya,K. Iekushi,M. Aoki,N. Dosaka,K. Matsumoto,T. Nakamura,T. Ogihara,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 16,p. 1206-1213,2006年08月
  • Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet,Y. Kunugiza,N. Tomita,Y. Taniyama,T. Tomita,M. K. Osako,K. Tamai,T. Tanabe,Y. Kaneda,H. Yoshikawa,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 15,p. 1143-1152,2006年08月
  • Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet,Y. Kunugiza,N. Tomita,Y. Taniyama,T. Tomita,M. K. Osako,K. Tamai,T. Tanabe,Y. Kaneda,H. Yoshikawa,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 15,p. 1143-1152,2006年08月
  • Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy,J. Azuma,Y. Taniyama,Y. Takeya,K. Iekushi,M. Aoki,N. Dosaka,K. Matsumoto,T. Nakamura,T. Ogihara,R. Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 16,p. 1206-1213,2006年08月
  • Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine,Hironori Nakagami,Namika Nakagawa,Yasushi Takeya,Katsunobu Kashiwagi,Chisato Ishida,Shin-ichiro Hayashi,Motokuni Aoki,Kunio Matsumoto,Toshikazu Nakamura,Toshio Ogihara,Ryuichi Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 48,No. 1,p. 112-119,2006年07月
  • Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine,Hironori Nakagami,Namika Nakagawa,Yasushi Takeya,Katsunobu Kashiwagi,Chisato Ishida,Shin-ichiro Hayashi,Motokuni Aoki,Kunio Matsumoto,Toshikazu Nakamura,Toshio Ogihara,Ryuichi Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 48,No. 1,p. 112-119,2006年07月
  • NF kappa B decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts,H Shimizu,H Nakagami,Tsukamoto, I,S Morita,Y Kunugiza,T Tomita,H Yoshikawa,Y Kaneda,T Ogihara,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 12,p. 933-941,2006年06月
  • Development of new screening system for Alzheimer disease, in vitro Aβsink assay, to identify the dissociation of soluble Aβfrom fibrils,Neurobiology of Disease,Vol. 22,No. 3,p. 487-495,2006年06月
  • Development of new screening system for Alzheimer disease, in vitro A beta sink assay, to identify the dissociation of soluble A beta from fibrils,N Sato,M Okochi,Y Taniyama,H Kurinami,M Shimamura,D Takeuchi,H Hamada,A Fukumori,K Kiyosue,T Taguchi,T Tanaka,M Miyasaka,M Takeda,T Ogihara,R Morishita,NEUROBIOLOGY OF DISEASE,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 22,No. 3,p. 487-495,2006年06月
  • NF kappa B decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts,H Shimizu,H Nakagami,Tsukamoto, I,S Morita,Y Kunugiza,T Tomita,H Yoshikawa,Y Kaneda,T Ogihara,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 12,p. 933-941,2006年06月
  • Development of High Throughput Functional Screening of Cardiovascular Therapeutic Genes Using the HVJ-E Vector,Tomoyuki Nishikawa,Hironori Nakagami,Atsuhi Matsuki,Yukihiro Saito,Ryuichi Morishita,Katsuto Tamai,Yasufumi Kaneda,MOLECULAR THERAPY,NATURE PUBLISHING GROUP,Vol. 13,p. S336-S336,2006年05月,研究発表ペーパー・要旨(国際会議)
  • The effect of VEGF on blood vessels and blood cells during Xenopus development,N Koibuchi,Y Taniyama,K Nagao,T Ogihara,Y Kaneda,R Morishita,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 344,No. 1,p. 339-345,2006年05月
  • The effect of VEGF on blood vessels and blood cells during Xenopus development,N Koibuchi,Y Taniyama,K Nagao,T Ogihara,Y Kaneda,R Morishita,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 344,No. 1,p. 339-345,2006年05月
  • Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide,Hironori Nakagami,Naruya Tomita,Yasufumi Kaneda,Toshio Ogihara,Ryuichi Morishita,CURRENT PHARMACEUTICAL BIOTECHNOLOGY,BENTHAM SCIENCE PUBL LTD,Vol. 7,No. 2,p. 95-100,2006年04月,書評論文,書評,文献紹介等
  • Prevention of abdominal aortic aneurysms by simultaneous inhibition of NF kappa B and ets using chimeric decoy oligonucleotides in a rabbit model,T Miyake,M Aoki,H Nakashima,T Kawasaki,M Oishi,K Kataoka,K Tanemoto,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 8,p. 695-704,2006年04月
  • Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction,M Shimamura,N Sato,S Waguri,Y Uchiyama,T Hayashi,H Iida,T Nakamura,T Ogihara,Y Kaneda,R Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 47,No. 4,p. 742-751,2006年04月
  • Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction,M Shimamura,N Sato,S Waguri,Y Uchiyama,T Hayashi,H Iida,T Nakamura,T Ogihara,Y Kaneda,R Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 47,No. 4,p. 742-751,2006年04月
  • Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide,Hironori Nakagami,Naruya Tomita,Yasufumi Kaneda,Toshio Ogihara,Ryuichi Morishita,CURRENT PHARMACEUTICAL BIOTECHNOLOGY,BENTHAM SCIENCE PUBL LTD,Vol. 7,No. 2,p. 95-100,2006年04月,書評論文,書評,文献紹介等
  • Prevention of abdominal aortic aneurysms by simultaneous inhibition of NF kappa B and ets using chimeric decoy oligonucleotides in a rabbit model,T Miyake,M Aoki,H Nakashima,T Kawasaki,M Oishi,K Kataoka,K Tanemoto,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 13,No. 8,p. 695-704,2006年04月
  • HVJ-based non-viral gene transfer method:successful gene therapy using HGF and VEGF genes in experimental ischemia.,Frontiers in Bioscience,Vol. 11:753-759,2006年
  • Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy,Jounal of Atherosclerosis and Thrombosis,2006年
  • Inhibitory effects of NFkB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein gragt model,Jounal of Molecular and Cellular Cardiology,Vol. 41:431-40,2006年
  • Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis.,Circulation,Vol. 12;114(11) 1177-84,2006年
  • HVJ-based non-viral gene transfer method:successful gene therapy using HGF and VEGF genes in experimental ischemia.,Frontiers in Bioscience,Vol. 11:753-759,2006年
  • Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy,Jounal of Atherosclerosis and Thrombosis,2006年
  • Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis.,Circulation,Vol. 12;114(11) 1177-84,2006年
  • Inhibitory effects of NFkB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein gragt model,Jounal of Molecular and Cellular Cardiology,Vol. 41:431-40,2006年
  • A scientific rationale for the CREST trial results: Evidence for the mechanism of action of cilostazol in restenosis,Ryuichi Morishita,Atherosclerosis Supplements,Vol. 6,No. 4,p. 41-46,2005年12月15日,書評論文,書評,文献紹介等
  • A scientific rationale for the CREST trial results: Evidence for the mechanism of action of cilostazol in restenosis,Ryuichi Morishita,ATHEROSCLEROSIS SUPPLEMENTS,ELSEVIER IRELAND LTD,Vol. 6,No. 4,p. 41-46,2005年12月
  • Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles,M Shimamura,N Sato,Y Taniyama,H Kurinami,H Tanaka,T Takami,T Ogihara,M Tohyama,Y Kaneda,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 11,p. 1468-1474,2005年11月
  • Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles,M Shimamura,N Sato,Y Taniyama,H Kurinami,H Tanaka,T Takami,T Ogihara,M Tohyama,Y Kaneda,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 11,p. 1468-1474,2005年11月
  • Inhibitory effect of ribbon (circular) type NF kappa B decoyoligodeoxynucleotides on induction and activity of osteoclasts.,Y Kunugiza,T Tomita,N Tomita,R Morishita,H Yoshikawa,ARTHRITIS AND RHEUMATISM,WILEY-BLACKWELL,Vol. 52,No. 9,p. S494-S494,2005年09月,研究発表ペーパー・要旨(国際会議)
  • Development of novel method of non-viral efficient gene transfer into neonatal cardiac myocytes,H Tashiro,M Aoki,M Isobe,N Hashiya,H Makino,Y Kaneda,T Ogihara,R Morishita,JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,Vol. 39,No. 3,p. 503-509,2005年09月
  • Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector,N Morishita,H Nakagami,R Morishita,S Takeda,F Mishima,B Terazono,S Nishijima,Y Kaneda,N Tanaka,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 334,No. 4,p. 1121-1126,2005年09月
  • Development of novel method of non-viral efficient gene transfer into neonatal cardiac myocytes,H Tashiro,M Aoki,M Isobe,N Hashiya,H Makino,Y Kaneda,T Ogihara,R Morishita,JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,Vol. 39,No. 3,p. 503-509,2005年09月
  • Recent progress in cerebrovascular gene therapy,Naoyuki Sato,Munehisa Shimamura,Ryuichi Morishita,Current Neurovascular Research,Vol. 2,No. 3,p. 235-247,2005年07月,書評論文,書評,文献紹介等
  • Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model,K Miwa,H Nakashima,M Aoki,T Miyake,T Kawasaki,M Iwai,M Oishi,K Kataoka,S Ohgi,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 12,No. 14,p. 1109-1118,2005年07月
  • Inhibition of ets, an essential transcription factor for angiogenesis, to prevent the development of abdominal aortic aneurysm in a rat model,K Miwa,H Nakashima,M Aoki,T Miyake,T Kawasaki,M Iwai,M Oishi,K Kataoka,S Ohgi,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 12,No. 14,p. 1109-1118,2005年07月
  • Does gene therapy become pharmacotherapy?,R Morishita,M Aoki,T Ogihara,EXPERIMENTAL PHYSIOLOGY,WILEY-BLACKWELL PUBLISHING, INC,Vol. 90,No. 3,p. 307-313,2005年05月
  • Does gene therapy become pharmacotherapy?,R Morishita,M Aoki,T Ogihara,EXPERIMENTAL PHYSIOLOGY,WILEY-BLACKWELL PUBLISHING, INC,Vol. 90,No. 3,p. 307-313,2005年05月
  • An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney,H Koike,N Tomita,H Azuma,Y Taniyama,K Yamasaki,Y Kunugiza,K Tachibana,T Ogihara,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 1,p. 108-116,2005年01月
  • Endothelial Dysfunction in Hyperglycemia as a Trigger of Atherosclerosis.,Current Diabetes Reviews,2005年
  • An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney,H Koike,N Tomita,H Azuma,Y Taniyama,K Yamasaki,Y Kunugiza,K Tachibana,T Ogihara,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 1,p. 108-116,2005年01月
  • Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis.,Current Diabetes Reviews,2005年
  • Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells.,Arterioscler Thromb Vasc Biol.,Vol. 25(12):2542-2547.,2005年
  • An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney,H Koike,N Tomita,H Azuma,Y Taniyama,K Yamasaki,Y Kunugiza,K Tachibana,T Ogihara,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 1,p. 108-116,2005年01月
  • An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney,H Koike,N Tomita,H Azuma,Y Taniyama,K Yamasaki,Y Kunugiza,K Tachibana,T Ogihara,R Morishita,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 7,No. 1,p. 108-116,2005年01月
  • Endothelial Dysfunction in Hyperglycemia as a Trigger of Atherosclerosis.,Current Diabetes Reviews,2005年
  • Recent Progress in Cerebrovasculare Gene Therapy,Current Neurovascular Research,Vol. Vol.2 No3:235-247,2005年
  • Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector,Biochem Biophys Res Commun.,Vol. 9;334(4):1121-6.,2005年
  • Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis.,Current Diabetes Reviews,2005年
  • Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells.,Arterioscler Thromb Vasc Biol.,Vol. 25(12):2542-2547.,2005年
  • VEGF isoforms differently contribute to development of blood vessels and blood cells in Xenopus,N Koibuchi,Y Taniyama,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 110,No. 17,p. 32-32,2004年10月,研究発表ペーパー・要旨(国際会議)
  • Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound,M Shimamura,N Sato,Y Taniyama,S Yamamoto,M Endoh,H Kurinami,M Aoki,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 11,No. 20,p. 1532-1539,2004年10月
  • Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor,K Yamasaki,M Aoki,H Makino,N Hashiya,H Shimizu,M Ohishi,T Ogihara,R Morishita,JOURNAL OF HUMAN HYPERTENSION,NATURE PUBLISHING GROUP,Vol. 18,No. 10,p. 701-705,2004年10月
  • Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor,K Yamasaki,M Aoki,H Makino,N Hashiya,H Shimizu,M Ohishi,T Ogihara,R Morishita,JOURNAL OF HUMAN HYPERTENSION,NATURE PUBLISHING GROUP,Vol. 18,No. 10,p. 701-705,2004年10月
  • Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound,M Shimamura,N Sato,Y Taniyama,S Yamamoto,M Endoh,H Kurinami,M Aoki,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 11,No. 20,p. 1532-1539,2004年10月
  • Is vascular endothelial growth factor a missing link between hypertension and inflammation?,Ryuichi Morishita,Hypertension,Vol. 44,No. 3,p. 253-254,2004年09月
  • Is vascular endothelial growth factor a missing link between hypertension and inflammation?,R Morishita,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 44,No. 3,p. 253-254,2004年09月
  • Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease,R Morishita,M Aoki,N Hashiya,H Makino,K Yamasaki,J Azuma,Y Sawa,H Matsuda,Y Kaneda,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 44,No. 2,p. 203-209,2004年08月
  • Safety evaluation of clinical gene therapy using hepatocyte growth factor to treat peripheral arterial disease,R Morishita,M Aoki,N Hashiya,H Makino,K Yamasaki,J Azuma,Y Sawa,H Matsuda,Y Kaneda,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 44,No. 2,p. 203-209,2004年08月
  • In vivo evidence of angiogenesis induced by transcription factor ets-1 - Ets-1 is located upstream of angiogenesis cascade,N Hashiya,N Jo,M Aoki,K Matsumoto,T Nakamura,Y Sato,N Ogata,T Ogihara,Y Kaneda,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 109,No. 24,p. 3035-3041,2004年06月
  • In vivo evidence of angiogenesis induced by transcription factor ets-1 - Ets-1 is located upstream of angiogenesis cascade,N Hashiya,N Jo,M Aoki,K Matsumoto,T Nakamura,Y Sato,N Ogata,T Ogihara,Y Kaneda,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 109,No. 24,p. 3035-3041,2004年06月
  • Effective acceleration of wound healing by simultaneous transfestion of hepatocyte growth factor gene and Prostacyclin synthase gene using Shima Jet,Y Kunugiza,N Tomita,T Tomita,H Hashimoto,K Yamasaki,H Koike,H Yoshikawa,R Morishita,MOLECULAR THERAPY,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 9,p. S397-S397,2004年05月,研究発表ペーパー・要旨(国際会議)
  • Perspective in progress of cardiovascular gene therapy,Ryuichi Morishita,Journal of Pharmacological Sciences,Vol. 95,No. 1,p. 1-8,2004年05月,書評論文,書評,文献紹介等
  • Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus,N Koibuchi,Y Kaneda,Y Taniyama,K Matsumoto,T Nakamura,T Ogihara,R Morishita,BLOOD,AMER SOC HEMATOLOGY,Vol. 103,No. 9,p. 3320-3325,2004年05月
  • Molecular therapy to inhibit NF kappa B activation by transcription factor decoy oligonucleotides,R Morishita,N Tomita,Y Kaneda,T Ogihara,CURRENT OPINION IN PHARMACOLOGY,ELSEVIER SCI LTD,Vol. 4,No. 2,p. 139-146,2004年04月,書評論文,書評,文献紹介等
  • Molecular therapy to inhibit NF kappa B activation by transcription factor decoy oligonucleotides,R Morishita,N Tomita,Y Kaneda,T Ogihara,CURRENT OPINION IN PHARMACOLOGY,ELSEVIER SCI LTD,Vol. 4,No. 2,p. 139-146,2004年04月,書評論文,書評,文献紹介等
  • A novel therapeutic strategy to treat brain ischemia: over-expression of hepatocyte growth factor gene reduced ischemic injury without brain edema in rat model.,M Shimamura,N Sato,M Aoki,S Waguri,Y Uchiyama,T Ogihara,Y Kaneda,R Morishita,STROKE,LIPPINCOTT WILLIAMS & WILKINS,Vol. 35,No. 1,p. 282-282,2004年01月,研究発表ペーパー・要旨(国際会議)
  • Perspective in progress of cardiovascular gene therapy.,Vol. 95(1)1-8,2004年
  • Gene Therapy vs Pharmacotherapy,2004年
  • Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: Role of Bcl-2, Bcl-xL, and Bax in tubular injury.,International fournal of molecular medicine,2004年
  • Enhanced tumor-specific long-term immunity of HVJ-mediated DC-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides.,J. Immunology,2004年
  • Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease accompanied by up-regulation of hepatocyte growth factor.,Hypertension Research,2004年
  • Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.,Hypertension Research,2004年
  • NF-KBと心血管疾患,心臓病診断と治療の最前線,Vol. 28,No. 93,2004年
  • Gene Therapy vs Pharmacotherapy,2004年
  • Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: Role of Bcl-2, Bcl-xL, and Bax in tubular injury.,International fournal of molecular medicine,2004年
  • Enhanced tumor-specific long-term immunity of HVJ-mediated DC-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides.,J. Immunology,2004年
  • Increase in peripheral blood flow by intravenous administration of prostaglandin E1 in patients with peripheral arterial disease accompanied by up-regulation of hepatocyte growth factor.,Hypertension Research,2004年
  • Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.,Hypertension Research,2004年
  • Periostin as a novel factor responsible for ventricular dilation,Circulation,Vol. 110,No. 13/ 1806,2004年
  • In vivo evidence of engiogenesis induced by transcription factor Ets-1:Ets-1 is located upstream of angiogenesis cascade,Circulation,No. 3035,2004年
  • Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model,T Namba,H Koike,K Murakami,M Aoki,H Makino,N Hashiya,T Ogihara,Y Kaneda,M Kohno,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 108,No. 18,p. 2250-2257,2003年11月
  • Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA,K Hiraoka,H Koike,S Yamamoto,N Tomita,C Yokoyama,T Tanabe,T Aikou,T Ogihara,Y Kaneda,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 108,No. 21,p. 2689-2696,2003年11月
  • Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model,T Namba,H Koike,K Murakami,M Aoki,H Makino,N Hashiya,T Ogihara,Y Kaneda,M Kohno,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 108,No. 18,p. 2250-2257,2003年11月
  • Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA,K Hiraoka,H Koike,S Yamamoto,N Tomita,C Yokoyama,T Tanabe,T Aikou,T Ogihara,Y Kaneda,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 108,No. 21,p. 2689-2696,2003年11月
  • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model,HY Lan,W Mu,N Tomita,XR Huang,JH Li,HJ Zhu,R Morishita,RJ Johnson,JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 14,No. 6,p. 1535-1548,2003年06月
  • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model,HY Lan,W Mu,N Tomita,XR Huang,JH Li,HJ Zhu,R Morishita,RJ Johnson,JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,LIPPINCOTT WILLIAMS & WILKINS,Vol. 14,No. 6,p. 1535-1548,2003年06月
  • HVJ-envelope vector for gene transfer into central nervous system,M Shimamura,R Morishita,M Endoh,K Oshima,M Aoki,S Waguri,Y Uchiyama,Y Kaneda,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 300,No. 2,p. 464-471,2003年01月
  • Oligonucleotide-based molecular therapy for restenosis after angioplasty.,Current Drug Targets,2003年
  • Oligonucleotide-based molecular therapy for restenosis after angioplasty.,Current Drug Targets,2003年
  • Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats.,Heart and Vessels,2003年
  • Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene,The FASEB Journal,2003年
  • Transfectio of NFkB decoy oligodeoxynucleotides using high efficient ultrasound-mediated gene transfer into the donor kidney prolonged survival of rat renal allograft.,Gene Therapy,2003年
  • HVJ-envelope vector for gene transfer into central nervous system,M Shimamura,R Morishita,M Endoh,K Oshima,M Aoki,S Waguri,Y Uchiyama,Y Kaneda,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 300,No. 2,p. 464-471,2003年01月
  • Oligonucleotide-based molecular therapy for restenosis after angioplasty.,Current Drug Targets,2003年
  • Oligonucleotide-based molecular therapy for restenosis after angioplasty.,Current Drug Targets,2003年
  • Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats.,Heart and Vessels,2003年
  • Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene,The FASEB Journal,2003年
  • Transfectio of NFkB decoy oligodeoxynucleotides using high efficient ultrasound-mediated gene transfer into the donor kidney prolonged survival of rat renal allograft.,Gene Therapy,2003年
  • Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue,K. Matsumoto,R. Morishita,N. Tomita,A. Moriguchi,K. Yamasaki,M. Aoki,K. Matsumoto,T. Nakamura,J. Higaki,T. Ogihara,Journal of Endocrinology,Vol. 175,No. 1,p. 217-223,2002年10月01日
  • Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue,K. Matsumoto,R. Morishita,N. Tomita,A. Moriguchi,K. Yamasaki,M. Aoki,K. Matsumoto,T. Nakamura,J. Higaki,T. Ogihara,Journal of Endocrinology,Vol. 175,No. 1,p. 217-223,2002年10月01日
  • Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells,N Komai,R Morishita,S Yamada,M Oishi,S Iguchi,M Aoki,M Sasaki,Sakurabayashi, I,J Higaki,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 40,No. 3,p. 310-314,2002年09月
  • Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes,N Tomita,R Morishita,K Yamamoto,J Higaki,VJ Dzau,T Ogihara,Y Kaneda,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 4,No. 5,p. 527-535,2002年09月
  • Mitogenic activity of oxidized lipoprotein (a) on human vascular smooth muscle cells,N Komai,R Morishita,S Yamada,M Oishi,S Iguchi,M Aoki,M Sasaki,Sakurabayashi, I,J Higaki,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 40,No. 3,p. 310-314,2002年09月
  • Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes,N Tomita,R Morishita,K Yamamoto,J Higaki,VJ Dzau,T Ogihara,Y Kaneda,JOURNAL OF GENE MEDICINE,JOHN WILEY & SONS LTD,Vol. 4,No. 5,p. 527-535,2002年09月
  • Nifedipine indirectly upregulates superoxide dismutase expression in endothelial cells via vascular smooth muscle cell-dependent pathways,K Fukuo,J Yang,O Yasuda,M Mogi,T Suhara,N Sato,T Suzuki,S Morimoto,T Ogihara,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 106,No. 3,p. 356-361,2002年07月
  • Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy,Y Taniyama,R Morishita,M Aoki,K Hiraoka,K Yamasaki,N Hashiya,K Matsumoto,T Nakamura,Y Kaneda,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 40,No. 1,p. 47-53,2002年07月
  • Nifedipine indirectly upregulates superoxide dismutase expression in endothelial cells via vascular smooth muscle cell-dependent pathways,K Fukuo,J Yang,O Yasuda,M Mogi,T Suhara,N Sato,T Suzuki,S Morimoto,T Ogihara,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 106,No. 3,p. 356-361,2002年07月
  • Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy,Y Taniyama,R Morishita,M Aoki,K Hiraoka,K Yamasaki,N Hashiya,K Matsumoto,T Nakamura,Y Kaneda,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 40,No. 1,p. 47-53,2002年07月
  • N141I mutant Presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression,Masaki Mori,Hironori Nakagami,Ryuichi Morishita,Noriaki Mitsuda,Kei Yamamoto,Shin-Ichi Yoshimura,Nobutaka Ohkubo,Naoyuki Sato,Toshio Ogihara,Yasufumi Kaneda,Life Sciences,Vol. 70,No. 21,p. 2567-2580,2002年04月12日
  • N141I mutant Presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression,Masaki Mori,Hironori Nakagami,Ryuichi Morishita,Noriaki Mitsuda,Kei Yamamoto,Shin-Ichi Yoshimura,Nobutaka Ohkubo,Naoyuki Sato,Toshio Ogihara,Yasufumi Kaneda,Life Sciences,Vol. 70,No. 21,p. 2567-2580,2002年04月12日
  • Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle,Y Taniyama,K Tachibana,K Hiraoka,M Aoki,S Yamamoto,K Matsumoto,T Nakamura,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 9,No. 6,p. 372-380,2002年03月
  • Local delivery of plasmid DNA into rat carotid artery using ultrasound,Y Taniyama,K Tachibana,K Hiraoka,T Namba,K Yamasaki,N Hashiya,M Aoki,T Ogihara,K Yasufumi,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 105,No. 10,p. 1233-1239,2002年03月
  • Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle,Y Taniyama,K Tachibana,K Hiraoka,M Aoki,S Yamamoto,K Matsumoto,T Nakamura,T Ogihara,Y Kaneda,R Morishita,GENE THERAPY,NATURE PUBLISHING GROUP,Vol. 9,No. 6,p. 372-380,2002年03月
  • Local delivery of plasmid DNA into rat carotid artery using ultrasound,Y Taniyama,K Tachibana,K Hiraoka,T Namba,K Yamasaki,N Hashiya,M Aoki,T Ogihara,K Yasufumi,R Morishita,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 105,No. 10,p. 1233-1239,2002年03月
  • Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients,Norio Komai,Mitsuru Ohishi,Ryuichi Morishita,Atsushi Moriguchi,Masaharu Kaibe,Keiko Matsumoto,Hiromi Rakugi,Jitsuo Higaki,Toshio Ogihara,American Journal of Hypertension,Vol. 15,No. 6,p. 499-506,2002年
  • Potential therapeutic applications of decoy oligonucleotides.,Current Opinion in Molecular Therapeutics,2002年
  • Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane.,Diabetes,2002年
  • Therapeutic approach to familial hypercholeserolemia by HVJ-liposomes in LDL receptor knockout mouse.,International Journal of Molecular Medicine,2002年
  • Hepatocyte growth factor (HGF) angiogenic gene therapy: promises for cardiocascular diseases,Gene Therapy and Reguration,Vol. 1,2002年
  • Potential therapeutic applications of decoy oligonucleotides.,Current Opinion in Molecular Therapeutics,2002年
  • Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane.,Diabetes,2002年
  • Therapeutic approach to familial hypercholeserolemia by HVJ-liposomes in LDL receptor knockout mouse.,International Journal of Molecular Medicine,2002年
  • Hepatocyte growth factor (HGF) angiogenic gene therapy: promises for cardiocascular diseases,Gene Therapy and Reguration,Vol. 1,2002年
  • Nuclear factor-kB decoy attenuates neuronal damage after global brain ischemia: A future strategy for brain protection during circulatory arrest,JTCS,2001年
  • Novel molecular therapeutic approach to cardiovascular disease based on hepatocyte growth factor.,Journal of Atherosclerosis and Thrombosis,2001年
  • Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons.,Gene Therapy,2001年
  • Therapeutic angiogenesis induced by hepatocyte growth factor: Potential gene therapy for ischemic diseases.,Journal of Atherosclerosis and Thrombosis,2001年
  • Additive effects of nicorandil on coronary blood flow during continuous adiministratiion of nitroglycerin.,Journal of the American College of Cardiology,2001年
  • Hypertension and genes.,Internal Medicine,2001年
  • Mitogenic and anti-apoptotic actions of hepatocyte growth factor through ERK, STAT3, and Akt in endothelial cells.,Hypertension,2001年
  • Therapeutic angioenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models: preslinical study for treatment of peripheral arterial disease.,Gene therapy,2001年
  • Inhibition of TNF-α-induced cytokine and adhesion molecule.,Experimental Nephrology,2001年
  • Contribution of bcl-2, but not bcl-xl and bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells.,Hypertention,2001年
  • Phosphorylation of p38MAP kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells.,Diabetes,2001年
  • Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice.,Gene therapy,2001年
  • Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model.,Circulation,2001年
  • Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model.,Diabetologia,2001年
  • Nuclear factor-kB decoy attenuates neuronal damage after global brain ischemia: A future strategy for brain protection during circulatory arrest,2001年
  • Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.,American Journal of Hypertension,2001年
  • Novel molecular therapeutic approach to cardiovascular disease based on hepatocyte growth factor.,Journal of Atherosclerosis and Thrombosis,2001年
  • Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons.,Gene Therapy,2001年
  • Hypertension and genes.,Internal Medicine,2001年
  • Mitogenic and anti-apoptotic actions of hepatocyte growth factor through ERK, STAT3, and Akt in endothelial cells.,Hypertension,2001年
  • Therapeutic angioenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models: preslinical study for treatment of peripheral arterial disease.,Gene therapy,2001年
  • Therapeutic angiogenesis induced by hepatocyte growth factor: Potential gene therapy for ischemic diseases.,Journal of Atherosclerosis and Thrombosis,2001年
  • Additive effects of nicorandil on coronary blood flow during continuous adiministratiion of nitroglycerin.,Journal of the American College of Cardiology,2001年
  • Inhibition of TNF-α-induced cytokine and adhesion molecule.,Experimental Nephrology,2001年
  • Contribution of bcl-2, but not bcl-xl and bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells.,Hypertention,2001年
  • Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model.,Circulation,2001年
  • Phosphorylation of p38MAP kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells.,Diabetes,2001年
  • Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice.,Gene therapy,2001年
  • Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction and induction of hepatocyte growth factor in rat diabetes model.,Diabetologia,2001年
  • Novel therapeutic strategy for restenosis using ribozyme oligonucleotides against transforming growth factor-beta,K Yamamoto,R Morishita,N Tomita,H Nakagami,M Aoki,J Higaki,Y Kaneda,T Ogihara,HYPERTENSION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 36,No. 4,p. 728-729,2000年10月,研究発表ペーパー・要旨(国際会議)
  • Hypoxia induced renal epithelial cell death through caspase-dependent pathway: Role of bcl-2, bcl-xL and bax in tubular injury,K Yamamoto,R Morishita,N Tomita,Y Taniyama,M Aoki,H Nakagami,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 102,No. 18,p. 517-517,2000年10月,研究発表ペーパー・要旨(国際会議)
  • Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.,Circulation,2000年
  • Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population,Clinical Genetics,2000年
  • In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy.,Arteriosclerosis, Thrombosis and Vascular Biology,2000年
  • Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infacted myocardium: up-regulation of essential trancription factor for angiogenesis, ets,Gene Therapy,2000年
  • Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smoth muscle cells,Circulation,2000年
  • Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters.,Circulation,2000年
  • In vivo administration of a nuclear transcription factor-κB decoy suppresses experimental crescentic glomerulonephritis,Journal of the American Society of Nephrology,2000年
  • Trancription factor decoy for NFκB inhibitis TNF-α-induced cytokine and adhesion molecule expression in vivo,Gene Therapy,2000年
  • Ribozyme oligonucleotides against transforming growth factor-β inhibited neointimal formation after vascular injury in rat model,Circulation,2000年
  • Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population,Clinical Genetics,2000年
  • Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.,Circulation,2000年
  • In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy.,Arteriosclerosis, Thrombosis and Vascular Biology,2000年
  • Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smoth muscle cells,Circulation,2000年
  • Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infacted myocardium: up-regulation of essential trancription factor for angiogenesis, ets,Gene Therapy,2000年
  • Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters.,Circulation,2000年
  • In vivo administration of a nuclear transcription factor-κB decoy suppresses experimental crescentic glomerulonephritis,Journal of the American Society of Nephrology,2000年
  • Trancription factor decoy for NFκB inhibitis TNF-α-induced cytokine and adhesion molecule expression in vivo,Gene Therapy,2000年
  • Ribozyme oligonucleotides against transforming growth factor-β inhibited neointimal formation after vascular injury in rat model,Circulation,2000年
  • Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: down-regulation of HGF in response to hypoxia in vascular cells.,Circulation,1999年
  • Supressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor [kappa]B decoy oligodeoxynucleotides as a gene therapy,Arthritis & Rheumatism,1999年
  • Prevention of cardiac allograft arteriopathy by antisense Cdc2 kinase oligonucleotide.,Transplant Proc,1999年
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo.,Circulation Research,1999年
  • Activation of the brain angiotensin system by in vivo human angiotensin-converting enzyme gene transfer in rats.,Hypertension,1999年
  • Angiotensinogen gene-activating elements regulate blood pressure in the brain,Circulation Research,1999年
  • Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats,Hypertension,1999年
  • Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells: potential role of p53 in regulation of vascular smooth muscle,Hypertension,1999年
  • Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: down-regulation of HGF in response to hypoxia in vascular cells.,Circulation,1999年
  • Supressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor [kappa]B decoy oligodeoxynucleotides as a gene therapy,Arthritis & Rheumatism,1999年
  • Prevention of cardiac allograft arteriopathy by antisense Cdc2 kinase oligonucleotide.,Transplant Proc,1999年
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo.,Circulation Research,1999年
  • Activation of the brain angiotensin system by in vivo human angiotensin-converting enzyme gene transfer in rats.,Hypertension,1999年
  • Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells: potential role of p53 in regulation of vascular smooth muscle,Hypertension,1999年
  • Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats,Hypertension,1999年
  • Angiotensinogen gene-activating elements regulate blood pressure in the brain,Circulation Research,1999年
  • Transfection of antisense p53 oligonucleotides into rat carotid artery resulted in an abnormal growth of vascular smooth muscle cells (VSMC), but not neovascularization: In vivo evidence of importance of p53 in the regulation of VSMC,H Matsushita,R Morishita,M Aoki,Y Kaneda,T Ogihara,CIRCULATION,LIPPINCOTT WILLIAMS & WILKINS,Vol. 98,No. 17,p. 797-798,1998年10月,研究発表ペーパー・要旨(国際会議)
  • Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease,R Morishita,J Higaki,N Tomita,T Ogihara,CIRCULATION RESEARCH,LIPPINCOTT WILLIAMS & WILKINS,Vol. 82,No. 10,p. 1023-1028,1998年06月,書評論文,書評,文献紹介等
  • Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease,R Morishita,J Higaki,N Tomita,T Ogihara,CIRCULATION RESEARCH,LIPPINCOTT WILLIAMS & WILKINS,Vol. 82,No. 10,p. 1023-1028,1998年06月,書評論文,書評,文献紹介等
  • Decoy administration of NF-kappa B into the subarachnoid space for cerebral angiopathy,S Ono,Date, I,K Onoda,T Shiota,T Ohmoto,Y Ninomiya,S Asari,R Morishita,HUMAN GENE THERAPY,MARY ANN LIEBERT INC PUBL,Vol. 9,No. 7,p. 1003-1011,1998年05月
  • 循環器疾患における転写因子「デコイ」の遺伝子治療及び研究への応用,82/,1023,Vol. 82,1998年
  • Decoy administration of NFkB into the subarachnoid space for cerebral angiopathy,ONO S,DATE I,ONODA K,SHIOTA T,OHMOTO T,NINOMIYA Y,ASARI S,MORISHITA R,9/,1003,Vol. 9,No. 7,p. 1003-1011,1998年
  • Oligonucleotide-based gene therapy for cardiovascular disease.,Clinical Chemistry and Laboratory Medicine,1998年
  • Potentila role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells.,Kidney International,1998年
  • Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery.,Gene Therapy,1998年
  • Hepatocyte growth factor as a potential index of complication in deabetes mellitus.,Journal of Hypertension,1998年
  • Gene transfer to vein graft wall by HVJ-liposome method: time course and localization of gene expression.,Ann Thorac Surg,1998年
  • Negative regulation of local hepatocyte growth factor (HGF) expression by angiotensin II and transforming growth factor-βin blood vessels: potential role of HGF in cardiovascular disease.,Hypertension,1998年
  • 循環器疾患における転写因子「デコイ」の遺伝子治療及び研究への応用,Vol. 82,1998年
  • Decoy administration of NFkB into the subarachnoid space for cerebral angiopathy,9/,1003,Vol. 9,No. 7,p. 1003-1011,1998年
  • Oligonucleotide-based gene therapy for cardiovascular disease.,Clinical Chemistry and Laboratory Medicine,1998年
  • Potentila role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells.,Kidney International,1998年
  • Efficient transfer of oligonucleotides and plasmid DNA into the whole heart through the coronary artery.,Gene Therapy,1998年
  • Hepatocyte growth factor as a potential index of complication in deabetes mellitus.,Journal of Hypertension,1998年
  • Negative regulation of local hepatocyte growth factor (HGF) expression by angiotensin II and transforming growth factor-βin blood vessels: potential role of HGF in cardiovascular disease.,Hypertension,1998年
  • Gene transfer to vein graft wall by HVJ-liposome method: time course and localization of gene expression.,Ann Thorac Surg,1998年
  • In vivo transfection of cis element clecoyagainst NFKB binding site prevented myocardial infarction as gene therapy.,3/,894,Vol. 3,1997年
  • Prevention of graft coronary arteriosclerosis by antisense cdk 2 kinase oligonrecleotile.,SUZUKI J,ISOBE M,AOKI M,HORIE S,OKUBO Y,KANEDA Y,SAWA Y,OGIHARA T,SEKIGUCHI M,3/,900,Vol. 3,No. 8,p. 900-903,1997年
  • Potential role of endothelimn-specific growth factor, hepertocyte growth factor, on endothelial damage in diabeter mallitus,46/,138,Vol. 46,1997年
  • Potential role of endothelimn-specific growth factor, hepertocyte growth factor, on endothelial damage in diabeter mallitus,Vol. 46,1997年
  • In vivo transfection of cis element clecoyagainst NFKB binding site prevented myocardial infarction as gene therapy.,Vol. 3,1997年
  • Prevention of graft coronary arteriosclerosis by antisense cdk 2 kinase oligonrecleotile.,Nature Medicine,Vol. 3,No. 8,p. 900-903,1997年
  • Prevention of graft coronary arteriosclerosis by antisense cdk 2 kinase oligonrecleotile.,Nature Medicine,Vol. 3,No. 8,p. 900-903,1997年
  • In vivo transfection of cis element "clecoy"against NFKB binding site prevented myocardial infarction as gene therapy.,Nature Medicine,Vol. 3,No. 8,p. 894-899,1997年
  • Potential role of endothelimn-specific growth factor, hepertocyte growth factor, on endothelial damage in diabeter mallitus,Diabetes,Vol. 46,1997年
  • Transcription factor decoy for NF kappa B inhibits TNF-alpha induced expressions of cytokine and adhesion molecule in mesangial cells.,N Tomita,R Morishita,GH Gibbons,S Tomita,Y Kaneda,T Ogihara,VJ Dzau,JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,AMER SOC NEPHROLOGY,Vol. 7,No. 9,p. A2382-A2382,1996年09月,研究発表ペーパー・要旨(国際会議)
  • Transfer of gene and oligodeoxynneleotides into skin of fetal rats by incubation in amniotic fluid,3/,878,Vol. 3,1996年
  • Role of transcriptional Cis-elements, angiotensinogh gene-activatiy element, of angiotensinogen gene in blood pressure regulation,27/,502,Vol. 27,1996年
  • Transfer of gene and oligodeoxynneleotides into skin of fetal rats by incubation in amniotic fluid,Vol. 3,1996年
  • Role of transcriptional Cis-elements, angiotensinogh gene-activatiy element, of angiotensinogen gene in blood pressure regulation,27/,502,Vol. 27,1996年
  • Transfer of gene and oligodeoxynneleotides into skin of fetal rats by incubation in amniotic fluid,Gene Therapy,Vol. 3,1996年
  • Role of transcriptional Cis-elements, angiotensinogh gene-activatiy element, of angiotensinogen gene in blood pressure regulation,Hypertension,Vol. 27,1996年
  • A GENE-THERAPY STRATEGY USING A TRANSCRIPTION FACTOR DECOY OF THE E2F BINDING-SITE INHIBITS SMOOTH-MUSCLE PROLIFERATION IN-VIVO,R MORISHITA,GH GIBBONS,M HORIUCHI,KE ELLISON,M NAKAJIMA,L ZHANG,Y KANEDA,T OGIHARA,VJ DZAU,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 92,No. 13,p. 5855-5859,1995年06月
  • A gene therapy strategy using a transcriptional factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo,MORISHITA R,GIBBONS G H,HORIUCHI M,ELLISON K E,NAKAJIMA M,ZHANG L,KANEDA Y,OGIHARA T,DZAU V J,92/,5855,Vol. 92,No. 13,p. 5855-5859,1995年
  • A gene therapy strategy using a transcriptional factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo,92/,5855,Vol. 92,No. 13,p. 5855-5859,1995年
  • INTIMAL HYPERPLASIA AFTER VASCULAR INJURY IS INHIBITED BY ANTISENSE CDK-2 KINASE OLIGONUCLEOTIDES,R MORISHITA,GH GIBBONS,KE ELLISON,M NAKAJIMA,H VONDERLEYEN,LN ZHANG,Y KANEDA,T OGIHARA,VJ DZAU,JOURNAL OF CLINICAL INVESTIGATION,ROCKEFELLER UNIV PRESS,Vol. 93,No. 4,p. 1458-1464,1994年04月
  • Intimal hyperplasia after vascular injuy is inhibited by antisense cdlc2 kinase oligonrcleotides,93/,1458,Vol. 93,1994年
  • Autocreie and paracrire effects of atrial natrmetic peptide gene transfer on vasurlar smooth muscle and endothelul cellwar growth.,94/,824,Vol. 94,1994年
  • Evidence for direct local effect of angiotersin in vaswlar hypertrophy : in viro gene transfer of angiotensin convertig engyme.,94/,978,Vol. 94,1994年
  • Intimal hyperplasia after vascular injuy is inhibited by antisense cdlc2 kinase oligonrcleotides,93/,1458,Vol. 93,1994年
  • Autocreie and paracrire effects of atrial natrmetic peptide gene transfer on vasurlar smooth muscle and endothelul cellwar growth.,94/,824,Vol. 94,1994年
  • Evidence for direct local effect of angiotersin in vaswlar hypertrophy : in viro gene transfer of angiotensin convertig engyme.,94/,978,Vol. 94,1994年
  • Evidence for direct local effect of angiotersin in vaswlar hypertrophy : in viro gene transfer of angiotensin convertig engyme.,Journal of Clinical Inverstigation,Vol. 94,1994年
  • Autocreie and paracrire effects of atrial natrmetic peptide gene transfer on vasurlar smooth muscle and endothelul cellwar growth.,Journal of Clinical Investigation,Vol. 94,1994年
  • ATRIAL-NATRIURETIC-PEPTIDE (ANP) GENE-TRANSFER ON CULTURED VASCULAR SMOOTH-MUSCLE CELLS (VSMC) AND ENDOTHELIAL-CELL GROWTH,R MORISHITA,GH GIBBONS,RE PRATT,N TOMITA,Y KANEDA,VJ DZAU,CIRCULATION,AMER HEART ASSOC,Vol. 88,No. 4,p. 181-181,1993年10月,研究発表ペーパー・要旨(国際会議)
  • A VIRAL-MEDIATED ANTISENSE OLIGONUCLEOTIDE DELIVERY SYSTEM TO PREVENT RESTENOSIS,R MORISHITA,GH GIBBONS,KE ELLISON,H VONDERLEYEN,L ZHANG,Y KANEDA,VJ DZAU,CIRCULATION,AMER HEART ASSOC,Vol. 88,No. 4,p. 371-371,1993年10月,研究発表ペーパー・要旨(国際会議)
  • AUTOCRINE PARACRINE RENIN-ANGIOTENSIN AS A DETERMINANT OF VASCULAR STRUCTURE - A GENE-TRANSFER APPROACH EXPERIMENT,R MORISHITA,GH GIBBONS,KE ELLISON,LN ZHANG,Y KANEDA,T OGIHARA,VJ DZAU,HYPERTENSION,AMER HEART ASSOC,Vol. 22,No. 3,p. 423-423,1993年09月,研究発表ペーパー・要旨(国際会議)
  • Single intralnmirel delivery of antisense cdc2 kinase and PCNA oligonncleotides results in chronic inhibition of reointil plasia.,90/,8474,Vol. 90,1993年
  • Single intralnmirel delivery of antisense cdc2 kinase and PCNA oligonncleotides results in chronic inhibition of reointil plasia.,90/,8474,Vol. 90,1993年
  • Single intralnmirel delivery of antisense cdc2 kinase and PCNA oligonncleotides results in chronic inhibition of reointil plasia.,Proceeding of National Academy of Sciences, USA,Vol. 90,No. 18,p. 8474-8478,1993年
  • 心筋梗塞の遺伝子治療,臨床と研究,Vol. 81

受賞

  • 第1回日本イノベーター大賞・優秀賞,2003年
  • 日本心血管内分泌学会高峰譲吉研究奨励賞,2001年
  • 日本高血圧学会若手研究奨励賞,2001年
  • 日本医師会研究奨励賞,1999年
  • 日本薬理学会第14回学術奨励賞,1999年
  • 日本内分泌学会若手研究奨励賞,1998年
  • 日本動脈硬化学会若手研究奨励賞,1996年
  • 日本循環器学会若手研究奨励賞最優秀賞,1996年
  • アメリカ高血圧評議会Harry Goldblatt Award,1996年
  • 成人病研究賞若手研究者研究奨励賞,1994年
  • 国際高血圧学会デムス若手奨励賞,1994年

委員歴

  • 学協会,アメリカ遺伝子治療学会,会長,1997年 ~
  • 学協会,循環器学会,会員,1997年 ~
  • 学協会,腎臓学会,評議員,1997年 ~
  • 学協会,動脈硬化学会,評議員,1997年 ~
  • 学協会,アメリカ高血圧評議会,評議員,1997年 ~
  • 学協会,アメリカ循環器学会,評議員,1997年 ~