EN

基本情報

研究

社会活動

その他の活動

大竹 洋輔

Ootake Yousuke

医学系研究科,特任助教(常勤)

keyword パーキンソン病,バイオマーカー,神経変性,脊髄損傷,神経軸索再生

研究内容・専門分野

  • ライフサイエンス,分子生物学
  • ライフサイエンス,病態神経科学
  • ライフサイエンス,神経科学一般

所属学会

  • 日本神経化学会
  • 日本生化学会

論文

  • Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury.,Fatima M Nathan,Yosuke Ohtake,Shuo Wang,Xinpei Jiang,Armin Sami,Hua Guo,Feng-Quan Zhou,Shuxin Li,Molecular therapy : the journal of the American Society of Gene Therapy,Vol. 28,No. 8,p. 1902-1917,2020年08月05日,研究論文(学術雑誌)
  • Immunotherapies in Huntington's disease and α-Synucleinopathies.,Oluwaseun Fatoba,Yosuke Ohtake,Takahide Itokazu,Toshihide Yamashita,Frontiers in immunology,Vol. 11,p. 337-337,2020年,研究論文(学術雑誌)
  • Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1.,Yosuke Ohtake,Armin Sami,Xinpei Jiang,Makoto Horiuchi,Kieran Slattery,Lena Ma,George M Smith,Michael E Selzer,Shin-Ichi Muramatsu,Shuxin Li,Molecular therapy : the journal of the American Society of Gene Therapy,Vol. 27,No. 1,p. 102-117,2019年01月02日,研究論文(学術雑誌)
  • S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy.,Tomoki Chiku,Motoki Hayashishita,Taro Saito,Mikiko Oka,Kanako Shinno,Yosuke Ohtake,Sawako Shimizu,Akiko Asada,Shin-Ichi Hisanaga,Koichi M Iijima,Kanae Ando,Neurobiology of aging,Vol. 71,p. 255-264,2018年11月,研究論文(学術雑誌)
  • Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems.,Ohtake Y,Saito A,Li S,Experimental neurology,Vol. 302,p. 196-204,2018年04月,研究論文(学術雑誌)
  • Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury.,Yosuke Ohtake,Koji Matsuhisa,Masayuki Kaneko,Soshi Kanemoto,Rie Asada,Kazunori Imaizumi,Atsushi Saito,Neuroscience,Vol. 375,p. 34-48,2018年04月01日,研究論文(学術雑誌)
  • Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma.,Atsushi Saito,Longjie Cai,Koji Matsuhisa,Yosuke Ohtake,Masayuki Kaneko,Soshi Kanemoto,Rie Asada,Kazunori Imaizumi,Journal of neurochemistry,Vol. 144,No. 1,p. 35-49,2018年01月,研究論文(学術雑誌)
  • Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.,Yan Wu,Xiao Peng Guo,Soshi Kanemoto,Yujiro Maeoka,Atsushi Saito,Rie Asada,Koji Matsuhisa,Yosuke Ohtake,Kazunori Imaizumi,Masayuki Kaneko,PloS one,Vol. 13,No. 1,2018年,研究論文(学術雑誌)
  • Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy.,Mikiko Oka,Naoki Fujisaki,Akiko Maruko-Otake,Yosuke Ohtake,Sawako Shimizu,Taro Saito,Shin-Ichi Hisanaga,Koichi M Iijima,Kanae Ando,Journal of biochemistry,OXFORD UNIV PRESS,Vol. 162,No. 5,p. 335-342,2017年11月01日,研究論文(学術雑誌)
  • Protein tyrosine phosphatase σ regulates autoimmune encephalomyelitis development.,Ohtake Y,Kong W,Hussain R,Horiuchi M,Tremblay ML,Ganea D,Li S,Brain, behavior, and immunity,Vol. 65,p. 111-124,2017年10月,研究論文(学術雑誌)
  • ER Stress and Disease: Toward Prevention and Treatment.,Masayuki Kaneko,Kazunori Imaizumi,Atsushi Saito,Soshi Kanemoto,Rie Asada,Koji Matsuhisa,Yosuke Ohtake,Biological & pharmaceutical bulletin,PHARMACEUTICAL SOC JAPAN,Vol. 40,No. 9,p. 1337-1343,2017年,研究論文(学術雑誌)
  • Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons.,Yosuke Ohtake,Daniella Wong,P M Abdul-Muneer,Michael E Selzer,Shuxin Li,Scientific reports,NATURE PUBLISHING GROUP,Vol. 6,p. 37152-37152,2016年11月16日,研究論文(学術雑誌)
  • Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.,Kanae Ando,Mikiko Oka,Yosuke Ohtake,Motoki Hayashishita,Sawako Shimizu,Shin-Ichi Hisanaga,Koichi M Iijima,Biochemical and biophysical research communications,Vol. 478,No. 2,p. 929-34,2016年09月16日,研究論文(学術雑誌)
  • Reactive astrocyte scar and axon regeneration: suppressor or facilitator?,Yosuke Ohtake,George M Smith,Shuxin Li,Neural regeneration research,MEDKNOW PUBLICATIONS & MEDIA PVT LTD,Vol. 11,No. 7,p. 1050-1,2016年07月
  • Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration.,Dechun Feng,Shen Dai,Fengming Liu,Yosuke Ohtake,Zhou Zhou,Hua Wang,Yonggang Zhang,Alison Kearns,Xiao Peng,Faliang Zhu,Umar Hayat,Man Li,Yong He,Mingjiang Xu,Chunling Zhao,Min Cheng,Lining Zhang,Hong Wang,Xiaofeng Yang,Cynthia Ju,Elizabeth C Bryda,Jennifer Gordon,Kamel Khalili,Wenhui Hu,Shuxin Li,Xuebin Qin,Bin Gao,The Journal of clinical investigation,Vol. 126,No. 6,p. 2321-33,2016年06月01日,研究論文(学術雑誌)
  • Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and A beta 42-Induced Tau Toxicity,Kanae Ando,Akiko Maruko-Otake,Yosuke Ohtake,Motoki Hayashishita,Michiko Sekiya,Koichi M. Iijima,PLOS GENETICS,PUBLIC LIBRARY SCIENCE,Vol. 12,No. 3,2016年03月,研究論文(学術雑誌)
  • Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.,Ando K,Maruko-Otake A,Ohtake Y,Hayashishita M,Sekiya M,Iijima KM,PLoS genetics,Vol. 12,No. 3,2016年03月,研究論文(学術雑誌)
  • Molecular mechanisms of scar-sourced axon growth inhibitors.,Yosuke Ohtake,Shuxin Li,Brain research,ELSEVIER SCIENCE BV,Vol. 1619,p. 22-35,2015年09月04日,研究論文(学術雑誌)
  • PTEN inhibition and axon regeneration and neural repair.,Yosuke Ohtake,Umar Hayat,Shuxin Li,Neural regeneration research,MEDKNOW PUBLICATIONS & MEDIA PVT LTD,Vol. 10,No. 9,p. 1363-8,2015年09月,研究論文(学術雑誌)
  • Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells.,Tomofumi Fujino,Akiko Maruko-Ohtake,Yosuke Ohtake,Tomonori Kobayashi,Ken Ando,Airi Takeuchi,Yasuhito Ohkubo,Makio Hayakawa,The Journal of toxicological sciences,JAPANESE SOC TOXICOLOGICAL SCIENCES,Vol. 40,No. 4,p. 501-8,2015年08月,研究論文(学術雑誌)
  • Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.,Bin Xu,Dongsun Park,Yosuke Ohtake,Hui Li,Umar Hayat,Junjun Liu,Michael E Selzer,Frank M Longo,Shuxin Li,Neurobiology of disease,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 73,p. 36-48,2015年01月,研究論文(学術雑誌)
  • The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury.,Yosuke Ohtake,Dongsun Park,P M Abdul-Muneer,Hui Li,Bin Xu,Kartavya Sharma,George M Smith,Michael E Selzer,Shuxin Li,Biomaterials,ELSEVIER SCI LTD,Vol. 35,No. 16,p. 4610-26,2014年05月,研究論文(学術雑誌)
  • Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation.,Tomofumi Fujino,Airi Takeuchi,Akiko Maruko-Ohtake,Yosuke Ohtake,Junichi Satoh,Tomonori Kobayashi,Toshiaki Tanaka,Haruka Ito,Ryosuke Sakamaki,Ryo Kashimura,Ken Ando,Tomoko Nishimaki-Mogami,Yasuhito Ohkubo,Naomi Kitamura,Ryuichiro Sato,Kiyomi Kikugawa,Makio Hayakawa,Journal of biochemistry,OXFORD UNIV PRESS,Vol. 152,No. 6,p. 577-86,2012年12月,研究論文(学術雑誌)
  • Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes.,Tomonori Kobayashi,Yohei Saito,Yosuke Ohtake,Akiko Maruko,Yumi Yamamoto,Fumihiko Yamamoto,Yoshikazu Kuwahara,Motoi Fukumoto,Manabu Fukumoto,Yasuhito Ohkubo,American journal of physiology. Gastrointestinal and liver physiology,Vol. 303,No. 7,p. G861-9-G869,2012年10月,研究論文(学術雑誌)
  • Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease-Related Tau Phosphorylation Via PAR-1,Kanae Iijima-Ando,Michiko Sekiya,Akiko Maruko-Otake,Yosuke Ohtake,Emiko Suzuki,Bingwei Lu,Koichi M. Iijima,PLOS GENETICS,PUBLIC LIBRARY SCIENCE,Vol. 8,No. 8,2012年08月,研究論文(学術雑誌)
  • Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.,Kanae Iijima-Ando,Michiko Sekiya,Akiko Maruko-Otake,Yosuke Ohtake,Emiko Suzuki,Bingwei Lu,Koichi M Iijima,PLoS genetics,8,Vol. 8,No. 8,2012年,研究論文(学術雑誌)
  • Norepinephrine modulates the zonally different hepatocyte proliferation through the regulation of transglutaminase activity.,Yosuke Ohtake,Tomonori Kobayashi,Akiko Maruko,Nao Oh-Ishi,Fumihiko Yamamoto,Shinsuke Katoh,Yasuhito Ohkubo,American journal of physiology. Gastrointestinal and liver physiology,AMER PHYSIOLOGICAL SOC,Vol. 299,No. 1,p. G106-14-G114,2010年07月,研究論文(学術雑誌)
  • X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes.,Akiko Maruko,Yosuke Ohtake,Masasumi Kawaguchi,Tomonori Kobayashi,Taisuke Baba,Yoshikazu Kuwahara,Hironobu Nakagawa,Tsutomu Shimura,Manabu Fukumoto,Yasuhito Ohkubo,Radiation research,Vol. 173,No. 5,p. 620-8,2010年05月,研究論文(学術雑誌)
  • The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure.,Yoshikazu Kuwahara,Miyuki Mori,Toshiyuki Oikawa,Tsutomu Shimura,Yosuke Ohtake,Shiro Mori,Yasuhito Ohkubo,Manabu Fukumoto,Journal of radiation research,Vol. 51,No. 3,p. 297-302,2010年,研究論文(学術雑誌)
  • Transglutaminase down‐regulates the dimerization of epidermal growth factor receptor in rat perivenous and periportal hepatocytes down‐regulates the dimerization of epidermal growth factor receptor in rat perivenous and periportal hepatocytes,Maruko A,Ohtake Y,Katoh S,Ohkubo Y,Cell Proliferation,Vol. 42,No. 5,p. 647-656,2009年10月
  • Stabilities of 67ga- and 111In-labeled transferrin in vitro.,Yosuke Ohtake,Akiko Maruko,Yoshikazu Kuwahara,Manabu Fukumoto,Yasuhito Ohkubo,Protein and peptide letters,Vol. 16,No. 2,p. 138-42,2009年,研究論文(学術雑誌)
  • The uptake of 111In in the liver and bone marrow of partially hepatectomized and venesectioned rats.,Yosuke Ohtake,Akiko Maruko,Satoko Satoh,Yasuhito Ohkubo,Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,Vol. 66,No. 9,p. 1245-9,2008年09月,研究論文(学術雑誌)
  • Effect of retinoic acid on transglutaminase and ornithine decarboxylase activities during liver regeneration.,Yosuke Ohtake,Akiko Maruko,Nao Ohishi,Masasumi Kawaguchi,Tetsuharu Satoh,Yasuhito Ohkubo,Cell biochemistry and function,Vol. 26,No. 3,p. 359-65,2008年04月,研究論文(学術雑誌)
  • Effect of aging on EGF-induced proliferative response in primary cultured periportal and perivenous hepatocytes.,Yosuke Ohtake,Akiko Maruko,Nao Ohishi,Manabu Fukumoto,Yasuhito Ohkubo,Journal of hepatology,ELSEVIER SCIENCE BV,Vol. 48,No. 2,p. 246-54,2008年02月,研究論文(学術雑誌)
  • Transglutaminase catalyzed dissociation and association of protein-polyamine complex.,Yosuke Ohtake,Tomomi Nagashima,Satoko Suyama-Satoh,Akiko Maruko,Noriko Shimura,Yasuhito Ohkubo,Life sciences,PERGAMON-ELSEVIER SCIENCE LTD,Vol. 81,No. 7,p. 577-84,2007年07月26日,研究論文(学術雑誌)
  • The effect of blood decrease on (67)Ga uptake by the liver in partially hepatectomized rats.,Yosuke Ohtake,Akiko Maruko,Satoko Satoh,Masasumi Kawaguchi,Yasuhito Ohkubo,Biological & pharmaceutical bulletin,Vol. 30,No. 5,p. 1011-4,2007年05月,研究論文(学術雑誌)
  • The uptake mechanism of gallium-67 into hepatocytes treated with carbon tetrachloride.,Shinya Abe,Satoko Suyama,Seiko Chiba,Hajime Nakao,Yosuke Ohtake,Yasuhito Ohkubo,Biological & pharmaceutical bulletin,PHARMACEUTICAL SOC JAPAN,Vol. 30,No. 2,p. 224-9,2007年02月,研究論文(学術雑誌)
  • Involvement of retinoic acid-induced transglutaminase activity in zonal differences of hepatocyte proliferation after partial hepatectomy.,Yosuke Ohtake,Akiko Maruko,Shinya Abe,Tomomi Nagashima,Manabu Fukumoto,Yasuhito Ohkubo,Journal of gastroenterology and hepatology,BLACKWELL PUBLISHING,Vol. 21,No. 11,p. 1726-30,2006年11月,研究論文(学術雑誌)
  • Zonal differences in gallium-67 uptakes between perivenous versus periportal regions of rat liver following carbon tetrachloride treatment.,Shinya Abe,Hajime Nakao,Kana Hatakeyama,Yosuke Ohtake,Soichi Kojima,Manabu Fukumoto,Yasuhito Ohkubo,Hepatology research : the official journal of the Japan Society of Hepatology,Vol. 36,No. 2,p. 78-85,2006年10月,研究論文(学術雑誌)
  • The involvement of transferrin in the uptake of iron-59 by hepatocytes of carbon tetrachloride-damaged rats.,Satoko Suyama,Shinya Abe,Yoshihiro Inoue,Ai Toukairin,Yosuke Ohtake,Yasuhito Ohkubo,Biological & pharmaceutical bulletin,PHARMACEUTICAL SOC JAPAN,Vol. 29,No. 7,p. 1387-90,2006年07月,研究論文(学術雑誌)
  • Transglutaminase differentially regulates growth signalling in rat perivenous and periportal hepatocytes,A Maruko,Y Ohtake,K Konno,S Abe,Y Ohkubo,CELL PROLIFERATION,BLACKWELL PUBLISHING,Vol. 39,No. 3,p. 183-193,2006年06月,研究論文(学術雑誌)
  • Effect of retinoic acid-induced transglutaminase on cell growth in regenerating liver.,Yosuke Ohtake,Akiko Maruko,Shinya Abe,Manabu Fukumoto,Yasuhito Ohkubo,Biomedical research (Tokyo, Japan),Vol. 27,No. 2,p. 75-80,2006年04月,研究論文(学術雑誌)
  • Photodegradation products of propranolol: the structures and pharmacological studies.,Koji Uwai,Marie Tani,Yosuke Ohtake,Shinya Abe,Akiko Maruko,Takashi Chiba,Yoshiro Hamaya,Yasuhito Ohkubo,Mitsuhiro Takeshita,Life sciences,PERGAMON-ELSEVIER SCIENCE LTD,Vol. 78,No. 4,p. 357-65,2005年12月12日,研究論文(学術雑誌)
  • The involvement of polyamines as substrates of transglutaminase in zonal different hepatocyte proliferation after partial hepatectomy.,Yosuke Ohtake,Satoko Suyama,Shinya Abe,Naoko Sato,Soichi Kojima,Manabu Fukumoto,Yasuhito Ohkubo,Biological & pharmaceutical bulletin,PHARMACEUTICAL SOC JAPAN,Vol. 28,No. 2,p. 349-52,2005年02月,研究論文(学術雑誌)
  • Uptake of Gallium-67 by the hepatocytes during liver regeneration in carbon tetrachloride-treated mice,S Abe,S Suyama,H Shishido,M Sato,Y Ohtake,N Sato,Y Ohkubo,BIOLOGICAL & PHARMACEUTICAL BULLETIN,PHARMACEUTICAL SOC JAPAN,Vol. 27,No. 12,p. 1913-1915,2004年12月,研究論文(学術雑誌)
  • Zonal differences in DNA synthesis and in transglutaminase activity between perivenous versus periportal regions of regenerating rat liver,Y Ohtake,A Maruko,S Kojima,T Ono,T Nagashima,M Fukumoto,S Suyama,S Abe,N Sato,Y Ohkubo,BIOLOGICAL & PHARMACEUTICAL BULLETIN,PHARMACEUTICAL SOC JAPAN,Vol. 27,No. 11,p. 1758-1762,2004年11月,研究論文(学術雑誌)
  • The entering of indium-111 and iron-59 into the hepatocytes from partially hepatectomized rats differ from that of gallium-67,R Sato,S Abe,Y Yamada,D Toyama,Y Ohtake,N Sato,Y Ohkubo,BIOLOGICAL & PHARMACEUTICAL BULLETIN,PHARMACEUTICAL SOC JAPAN,Vol. 27,No. 8,p. 1193-1196,2004年08月,研究論文(学術雑誌)
  • Development of an experimental system for evaluation of stress effect on ethyl alcohol metabolism using radiorespirometric analysis in rat,A Maruko,Y Ohtake,A Suzuki,N Sato,Y Ohkubo,BIOLOGICAL & PHARMACEUTICAL BULLETIN,PHARMACEUTICAL SOC JAPAN,Vol. 27,No. 4,p. 567-569,2004年04月,研究論文(学術雑誌)
  • Relationship between liver injury and transglutaminase activities in guinea pigs and rats,N Sato,S Abe,T Yamada,K Iwasaki,Y Ohtake,Y Ohkubo,BIOLOGICAL & PHARMACEUTICAL BULLETIN,PHARMACEUTICAL SOC JAPAN,Vol. 27,No. 2,p. 236-238,2004年02月,研究論文(学術雑誌)
  • Inhibitory and promotive effects of polyamines on transglutaminase-induced protein polymerization,N Sato,Y Ohtake,H Kohno,S Abe,Y Ohkubo,PROTEIN AND PEPTIDE LETTERS,BENTHAM SCIENCE PUBL LTD,Vol. 10,No. 4,p. 396-403,2003年08月,研究論文(学術雑誌)
  • Effects of polyamines on histone polymerization,N Sato,Y Ohtake,H Kato,S Abe,H Kohno,Y Ohkubo,JOURNAL OF PROTEIN CHEMISTRY,KLUWER ACADEMIC/PLENUM PUBL,Vol. 22,No. 3,p. 303-307,2003年04月,研究論文(学術雑誌)

MISC

  • DEVELOP A NOVEL STRATEGY TO ENHANCE AXON REGENERATION AND NEUROPLASTICITY AFTER CNS INJURY,Shuxin Li,Yosuke Ohtake,Lena Ma,Makoto Horiuchi,Jason Berke,Shin-Ichi Muramatsu,JOURNAL OF NEUROTRAUMA,MARY ANN LIEBERT, INC,Vol. 34,No. 13,p. A142-A143,2017年07月,研究発表ペーパー・要旨(国際会議)
  • DEVELOP A NOVEL STRATEGY TO ENHANCE AXON REGENERATION AND NEUROPLASTICITY AFTER CNS INJURY,Shuxin Li,Yosuke Ohtake,Lena Ma,Makoto Horiuchi,Jason Berke,Shin-Ichi Muramatsu,JOURNAL OF NEUROTRAUMA,MARY ANN LIEBERT, INC,Vol. 34,No. 13,p. A158-A158,2017年07月,研究発表ペーパー・要旨(国際会議)
  • Deficiency of protein tyrosine phosphatase sigma abolishes resistance of BALB/c mice to EAE by modulating dendritic cell function,Weimin Kong,Yosuke Ohtake,Shuxin Li,Doina Ganea,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 196,2016年05月,研究発表ペーパー・要旨(国際会議)