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研究

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豊福 利彦

Toyofuku Toshihiko

医学系研究科,特任教授(常勤)

論文

  • Laminin-221 Enhances Therapeutic Effects of Human-Induced Pluripotent Stem Cell-Derived 3-Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model.,Takaaki Samura,Shigeru Miyagawa,Takuji Kawamura,Satsuki Fukushima,Jun-Ya Yokoyama,Maki Takeda,Akima Harada,Fumiya Ohashi,Ryoko Sato-Nishiuchi,Toshihiko Toyofuku,Koichi Toda,Kiyotoshi Sekiguchi,Yoshiki Sawa,Journal of the American Heart Association,Vol. 9,No. 16,2020年08月18日,研究論文(学術雑誌)
  • Publisher Correction: Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.,Shohei Yoshida,Shigeru Miyagawa,Toshihiko Toyofuku,Satsuki Fukushima,Takuji Kawamura,Ai Kawamura,Noriyuki Kashiyama,Yuki Nakamura,Koichi Toda,Yoshiki Sawa,Scientific reports,Vol. 10,No. 1,p. 10058-10058,2020年06月17日
  • Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.,Shohei Yoshida,Shigeru Miyagawa,Toshihiko Toyofuku,Satsuki Fukushima,Takuji Kawamura,Ai Kawamura,Noriyuki Kashiyama,Yuki Nakamura,Koichi Toda,Yoshiki Sawa,Scientific reports,Vol. 10,No. 1,p. 4593-4593,2020年03月12日,研究論文(学術雑誌)
  • Blockade of N-Glycosylation Promotes Antitumor Immune Response of T Cells.,Shigemi Sasawatari,Yuki Okamoto,Atsushi Kumanogoh,Toshihiko Toyofuku,Journal of immunology (Baltimore, Md. : 1950),Vol. 204,No. 5,p. 1373-1385,2020年03月01日,研究論文(学術雑誌)
  • LRRK2 regulates endoplasmic reticulum-mitochondrial tethering through the PERK-mediated ubiquitination pathway.,Toshihiko Toyofuku,Yuki Okamoto,Takako Ishikawa,Shigemi Sasawatari,Atsushi Kumanogoh,The EMBO journal,Vol. 39,No. 2,2020年01月15日,研究論文(学術雑誌)
  • Natural killer cells impede the engraftment of cardiomyocytes derived from induced pluripotent stem cells in syngeneic mouse model.,Yuki Nakamura,Shigeru Miyagawa,Shohei Yoshida,Shigemi Sasawatari,Toshihiko Toyofuku,Koichi Toda,Yoshiki Sawa,Scientific reports,Vol. 9,No. 1,p. 10840-10840,2019年07月25日,研究論文(学術雑誌)
  • Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells.,Shohei Yoshida,Shigeru Miyagawa,Satsuki Fukushima,Takuji Kawamura,Noriyuki Kashiyama,Fumiya Ohashi,Toshihiko Toyofuku,Koichi Toda,Yoshiki Sawa,Molecular therapy : the journal of the American Society of Gene Therapy,Vol. 26,No. 11,p. 2681-2695,2018年11月07日,研究論文(学術雑誌)
  • Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.,Sujin Kang,Yoshimitsu Nakanishi,Yoshiyuki Kioi,Daisuke Okuzaki,Tetsuya Kimura,Hyota Takamatsu,Shohei Koyama,Satoshi Nojima,Masayuki Nishide,Yoshitomo Hayama,Yuhei Kinehara,Yasuhiro Kato,Takeshi Nakatani,Tomomi Shimogori,Junichi Takagi,Toshihiko Toyofuku,Atsushi Kumanogoh,Nature immunology,Vol. 19,No. 6,p. 561-570,2018年06月,研究論文(学術雑誌)
  • Correction for Toyofuku et al., "Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation".,Toshihiko Toyofuku,Keiko Morimoto,Shigemi Sasawatari,Atsusi Kumanogoh,Molecular and cellular biology,Vol. 38,No. 8,2018年04月15日,研究論文(学術雑誌)
  • LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.,Keiko Morimoto,Yoshihiro Baba,Hisaaki Shinohara,Sujin Kang,Satoshi Nojima,Tetsuya Kimura,Daisuke Ito,Yuji Yoshida,Yohei Maeda,Hana Sarashina-Kida,Masayuki Nishide,Takashi Hosokawa,Yasuhiro Kato,Yoshitomo Hayama,Yuhei Kinehara,Tatsusada Okuno,Hyota Takamatsu,Toru Hirano,Yoshihito Shima,Masashi Narazaki,Tomohiro Kurosaki,Toshihiko Toyofuku,Atsushi Kumanogoh,Scientific reports,Vol. 6,p. 25738-25738,2016年05月11日,研究論文(学術雑誌)
  • Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation.,Toshihiko Toyofuku,Keiko Morimoto,Shigemi Sasawatari,Atsushi Kumanogoh,Molecular and cellular biology,Vol. 35,No. 17,p. 3044-58,2015年09月01日,研究論文(学術雑誌)
  • mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.,Daisuke Ito,Satoshi Nojima,Masayuki Nishide,Tatsusada Okuno,Hyota Takamatsu,Sujin Kang,Tetsuya Kimura,Yuji Yoshida,Keiko Morimoto,Yohei Maeda,Takashi Hosokawa,Toshihiko Toyofuku,Jun Ohshima,Daisuke Kamimura,Masahiro Yamamoto,Masaaki Murakami,Eiichi Morii,Hiromi Rakugi,Yoshitaka Isaka,Atsushi Kumanogoh,Journal of immunology (Baltimore, Md. : 1950),Vol. 195,No. 3,p. 934-43,2015年08月01日,研究論文(学術雑誌)
  • A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration.,Satoshi Nojima,Toshihiko Toyofuku,Hiroyuki Kamao,Chie Ishigami,Jun Kaneko,Tatsusada Okuno,Hyota Takamatsu,Daisuke Ito,Sujin Kang,Tetsuya Kimura,Yuji Yoshida,Keiko Morimoto,Yohei Maeda,Atsushi Ogata,Masahito Ikawa,Eiichi Morii,Katsuyuki Aozasa,Junichi Takagi,Masayo Takahashi,Atsushi Kumanogoh,Nature communications,Vol. 4,p. 1406-1406,2013年,研究論文(学術雑誌)
  • DNA damage in rheumatoid arthritis: an age-dependent increase in the lipid peroxidation-derived DNA adduct, heptanone-etheno-2'-deoxycytidine.,Masako Ogawa,Tomonari Matsuda,Atsushi Ogata,Toshimitsu Hamasaki,Atsushi Kumanogoh,Toshihiko Toyofuku,Toshio Tanaka,Autoimmune diseases,Vol. 2013,p. 183487-183487,2013年,研究論文(学術雑誌)
  • Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis.,Yuji Nakatsuji,Tatsusada Okuno,Masayuki Moriya,Tomoyuki Sugimoto,Makoto Kinoshita,Hyota Takamatsu,Satoshi Nojima,Tetsuya Kimura,Sujin Kang,Daisuke Ito,Yukinobu Nakagawa,Toshihiko Toyofuku,Kazushiro Takata,Misa Nakano,Masato Kubo,Sinobu Suzuki,Akiko Matsui-Hasumi,Ayako Uto-Konomi,Atsushi Ogata,Hideki Mochizuki,Saburo Sakoda,Atsushi Kumanogoh,Journal of immunology (Baltimore, Md. : 1950),Vol. 188,No. 10,p. 4858-65,2012年05月15日,研究論文(学術雑誌)
  • Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.,Toshihiko Toyofuku,Satoshi Nojima,Takako Ishikawa,Hyota Takamatsu,Tohru Tsujimura,Akiyoshi Uemura,Junko Matsuda,Takaharu Seki,Atsushi Kumanogoh,Genes & development,Vol. 26,No. 8,p. 816-29,2012年04月15日,研究論文(学術雑誌)
  • Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.,Sujin Kang,Tatsusada Okuno,Noriko Takegahara,Hyota Takamatsu,Satoshi Nojima,Tetsuya Kimura,Yuji Yoshida,Daisuke Ito,Saori Ohmae,Dong-Ju You,Toshihiko Toyofuku,Myoung Ho Jang,Atsushi Kumanogoh,Journal of immunology (Baltimore, Md. : 1950),Vol. 188,No. 3,p. 1108-16,2012年02月01日,研究論文(学術雑誌)
  • Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.,Yukinobu Nakagawa,Hyota Takamatsu,Tatsusada Okuno,Sujin Kang,Satoshi Nojima,Tetsuya Kimura,Tatsuki R Kataoka,Masahito Ikawa,Toshihiko Toyofuku,Ichiro Katayama,Atsushi Kumanogoh,Journal of immunology (Baltimore, Md. : 1950),Vol. 186,No. 5,p. 2881-8,2011年03月01日,研究論文(学術雑誌)
  • Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements.,Noriko Takegahara,Sujin Kang,Satoshi Nojima,Hyota Takamatsu,Tatsusada Okuno,Hitoshi Kikutani,Toshihiko Toyofuku,Atsushi Kumanogoh,FASEB journal : official publication of the Federation of American Societies for Experimental Biology,Vol. 24,No. 12,p. 4782-92,2010年12月,研究論文(学術雑誌)
  • Structural basis for semaphorin signalling through the plexin receptor.,Terukazu Nogi,Norihisa Yasui,Emiko Mihara,Yukiko Matsunaga,Masanori Noda,Naoya Yamashita,Toshihiko Toyofuku,Susumu Uchiyama,Yoshio Goshima,Atsushi Kumanogoh,Junichi Takagi,Nature,Vol. 467,No. 7319,p. 1123-7,2010年10月28日,研究論文(学術雑誌)
  • Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.,Hyota Takamatsu,Noriko Takegahara,Yukinobu Nakagawa,Michio Tomura,Masahiko Taniguchi,Roland H Friedel,Helen Rayburn,Marc Tessier-Lavigne,Yutaka Yoshida,Tatsusada Okuno,Masayuki Mizui,Sujin Kang,Satoshi Nojima,Tohru Tsujimura,Yuji Nakatsuji,Ichiro Katayama,Toshihiko Toyofuku,Hitoshi Kikutani,Atsushi Kumanogoh,Nature immunology,Vol. 11,No. 7,p. 594-600,2010年07月,研究論文(学術雑誌)
  • Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis.,Tatsusada Okuno,Yuji Nakatsuji,Masayuki Moriya,Hyota Takamatsu,Satoshi Nojima,Noriko Takegahara,Toshihiko Toyofuku,Yukinobu Nakagawa,Sujin Kang,Roland H Friedel,Saburo Sakoda,Hitoshi Kikutani,Atsushi Kumanogoh,Journal of immunology (Baltimore, Md. : 1950),Vol. 184,No. 3,p. 1499-506,2010年02月01日,研究論文(学術雑誌)
  • Involvement of Sema4A in the progression of experimental autoimmune myocarditis.,Nobuhiko Makino,Toshihiko Toyofuku,Noriko Takegahara,Hyota Takamatsu,Tatsusada Okuno,Yukinobu Nakagawa,Sujin Kang,Satoshi Nojima,Masatsugu Hori,Hitoshi Kikutani,Atsushi Kumanogoh,FEBS letters,Vol. 582,No. 28,p. 3935-40,2008年11月26日,研究論文(学術雑誌)
  • Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.,Toshihiko Toyofuku,Junko Yoshida,Tamiko Sugimoto,Midori Yamamoto,Nobuhiko Makino,Hyota Takamatsu,Noriko Takegahara,Fumikazu Suto,Masatsugu Hori,Hajime Fujisawa,Atsushi Kumanogoh,Hitoshi Kikutani,Developmental biology,Vol. 321,No. 1,p. 251-62,2008年09月01日,研究論文(学術雑誌)
  • Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.,Toshihiko Toyofuku,Masanori Yabuki,Junko Kamei,Motohiro Kamei,Nobuhiko Makino,Atsushi Kumanogoh,Masatsugu Hori,The EMBO journal,Vol. 26,No. 5,p. 1373-84,2007年03月07日,研究論文(学術雑誌)
  • Semaphorin signaling during cardiac development.,Toshihiko Toyofuku,Hitoshi Kikutani,Advances in experimental medicine and biology,Vol. 600,p. 109-17,2007年,研究論文(学術雑誌)
  • Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.,Noriko Takegahara,Hyota Takamatsu,Toshihiko Toyofuku,Tohru Tsujimura,Tatsusada Okuno,Kazunori Yukawa,Masayuki Mizui,Midori Yamamoto,Durbaka V R Prasad,Kazuhiro Suzuki,Masaru Ishii,Kenta Terai,Masayuki Moriya,Yuji Nakatsuji,Saburo Sakoda,Shintaro Sato,Shizuo Akira,Kiyoshi Takeda,Masanori Inui,Toshiyuki Takai,Masahito Ikawa,Masaru Okabe,Atsushi Kumanogoh,Hitoshi Kikutani,Nature cell biology,Vol. 8,No. 6,p. 615-22,2006年06月,研究論文(学術雑誌)
  • FARP2 triggers signals for Sema3A-mediated axonal repulsion.,Toshihiko Toyofuku,Junko Yoshida,Tamiko Sugimoto,Hong Zhang,Atsushi Kumanogoh,Masatsugu Hori,Hitoshi Kikutani,Nature neuroscience,Vol. 8,No. 12,p. 1712-9,2005年12月,研究論文(学術雑誌)
  • Semaphorins in the immune system,A. Kumanogoh,T. Shikina,K. Suzuki,M. Yamamoto,H. Takamatsu,N. Takegahara,S. Marukawa,I. Ishida,D. V.R. Prasad,T. Toyofuku,H. Kikutani,International Congress Series,Vol. 1285,p. 202-206,2005年11月,研究論文(学術雑誌)
  • Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.,Atsushi Kumanogoh,Takashi Shikina,Chie Watanabe,Noriko Takegahara,Kazuhiro Suzuki,Midori Yamamoto,Hyota Takamatsu,Durbaka V R Prasad,Masayuki Mizui,Toshihiko Toyofuku,Manabu Tamura,Dai Watanabe,Jane R Parnes,Hitoshi Kikutani,International immunology,Vol. 17,No. 10,p. 1277-82,2005年10月,研究論文(学術雑誌)
  • Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.,Atsushi Kumanogoh,Takashi Shikina,Kazuhiro Suzuki,Satoshi Uematsu,Kazunori Yukawa,Shin-Ichiro Kashiwamura,Hiroko Tsutsui,Midori Yamamoto,Hyota Takamatsu,Elizabeth P Ko-Mitamura,Noriko Takegahara,Satoko Marukawa,Isao Ishida,Hiroshi Morishita,Durbaka V R Prasad,Manabu Tamura,Masayuki Mizui,Toshihiko Toyofuku,Shizuo Akira,Kiyoshi Takeda,Masaru Okabe,Hitoshi Kikutani,Immunity,Vol. 22,No. 3,p. 305-16,2005年03月,研究論文(学術雑誌)
  • Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling.,Toshihiko Toyofuku,Hong Zhang,Atsushi Kumanogoh,Noriko Takegahara,Masanori Yabuki,Koichiro Harada,Masatsugu Hori,Hitoshi Kikutani,Nature cell biology,Vol. 6,No. 12,p. 1204-11,2004年12月,研究論文(学術雑誌)
  • Down-regulation of connexin43 in early myocardial ischemia and protective effect by ischemic preconditioning in rat hearts in vivo.,Kazuhito Hatanaka,Hiroyuki Kawata,Toshihiko Toyofuku,Ken-ichi Yoshida,Japanese heart journal,Vol. 45,No. 6,p. 1007-19,2004年11月,研究論文(学術雑誌)
  • Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.,Toshihiko Toyofuku,Hong Zhang,Atsushi Kumanogoh,Noriko Takegahara,Fumikazu Suto,Junko Kamei,Kazuhiro Aoki,Masanori Yabuki,Masatsugu Hori,Hajime Fujisawa,Hitoshi Kikutani,Genes & development,Vol. 18,No. 4,p. 435-47,2004年02月15日,研究論文(学術雑誌)
  • GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin gene.,Hong Zhang,Toshihiko Toyofuku,Junko Kamei,Masatsugu Hori,Biochemical and biophysical research communications,Vol. 312,No. 4,p. 1033-8,2003年12月26日,研究論文(学術雑誌)
  • Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation.,Junko Kamei,Toshihiko Toyofuku,Masatsugu Hori,Biochemical and biophysical research communications,Vol. 312,No. 2,p. 380-7,2003年12月12日,研究論文(学術雑誌)
  • Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy.,Hiroyuki Nakayama,Kinya Otsu,Osamu Yamaguchi,Kazuhiko Nishida,Moto-o Date,Kenichi Hongo,Yoichiro Kusakari,Toshihiko Toyofuku,Shungo Hikoso,Kazunori Kashiwase,Toshihiro Takeda,Yasushi Matsumura,Satoshi Kurihara,Masatsugu Hori,Michihiko Tada,FASEB journal : official publication of the Federation of American Societies for Experimental Biology,Vol. 17,No. 1,p. 61-3,2003年01月,研究論文(学術雑誌)

MISC

  • 関節リウマチ患者における過酸化脂質由来DNA付加体HεdCの年齢依存的増加,小川真佐子,松田知成,緒方篤,緒方篤,濱崎俊光,熊ノ郷淳,熊ノ郷淳,豊福利彦,田中敏朗,田中敏朗,日本分子生物学会年会プログラム・要旨集(Web),Vol. 35th,2012年