EN

基本情報

研究

社会活動

その他の活動

香山 尚子

Kayama Hisako

高等共創研究院,准教授

keyword 自然免疫,粘膜免疫

学歴

  • 2007年04月 ~ 2009年03月,大阪大学大学院,医学系研究科

経歴

  • ~ 継続中,大阪大学,高等共創研究院

研究内容・専門分野

  • ライフサイエンス,免疫学

所属学会

  • 日本免疫学会

論文

  • The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.,Haruka Tani,Bo Li,Takashi Kusu,Ryu Okumura,Junichi Nishimura,Daisuke Okuzaki,Daisuke Motooka,Shoya Arakawa,Asuka Mori,Terukazu Yoshihara,Takayuki Ogino,Shih-Han Tsai,Yoki Furuta,Masato Muneta,Shota Nakamura,Eiichiro Fukusaki,Kimiko Yamamoto,Hideo Yagita,Hisako Kayama,Kiyoshi Takeda,Proceedings of the National Academy of Sciences of the United States of America,Vol. 118,No. 39,2021年09月28日,研究論文(学術雑誌)
  • Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier,Sotaro Ozaka,Akira Sonoda,Shimpei Ariki,Naganori Kamiyama,Shinya Hidano,Nozomi Sachi,Kanako Ito,Yoko Kudo,Mizuki Minata,Benjawan Saechue,Astri Dewayani,Thanyakorn Chalalai,Yasuhiro Soga,Yuya Takahashi,Chiaki Fukuda,Kazuhiro Mizukami,Ryu Okumura,Hisako Kayama,Kazunari Murakami,Kiyoshi Takeda,Takashi Kobayashi,Genes to Cells,Wiley,2021年08月17日,研究論文(学術雑誌)
  • Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling.,Makoto Matsushita,Kazutoshi Fujita,Takuji Hayashi,Hisako Kayama,Daisuke Motooka,Hiroaki Hase,Kentaro Jingushi,Gaku Yamamichi,Satoru Yumiba,Eisuke Tomiyama,Yoko Koh,Yujiro Hayashi,Kosuke Nakano,Cong Wang,Yu Ishizuya,Taigo Kato,Koji Hatano,Atsunari Kawashima,Takeshi Ujike,Motohide Uemura,Ryoichi Imamura,Maria D C Rodriguez Pena,Jennifer B Gordetsky,George J Netto,Kazutake Tsujikawa,Shota Nakamura,Kiyoshi Takeda,Norio Nonomura,Cancer research,2021年05月26日,研究論文(学術雑誌)
  • Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis.,Naoko Okiyama,Yuki Ichimura,Miwako Shobo,Ryota Tanaka,Noriko Kubota,Akimasa Saito,Yosuke Ishitsuka,Rei Watanabe,Yasuhiro Fujisawa,Yoshiyuki Nakamura,Akihiro Murakami,Hisako Kayama,Kiyoshi Takeda,Manabu Fujimoto,Annals of the rheumatic diseases,2021年04月02日,研究論文(学術雑誌)
  • Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites.,Hisako Kayama,Kiyoshi Takeda,European journal of immunology,Vol. 50,No. 7,p. 921-931,2020年07月,研究論文(学術雑誌)
  • Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.,Asuka Yasueda,Hisako Kayama,Michiko Murohashi,Junichi Nishimura,Koji Wakame,Ken-Ichi Komatsu,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Toru Kitagawa,Kiyoshi Takeda,Toshinori Ito,Yuichiro Doki,Hidetoshi Eguchi,Shigeomi Shimizu,Tsunekazu Mizushima,Scientific reports,Vol. 10,No. 1,p. 9972-9972,2020年06月19日,研究論文(学術雑誌)
  • TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.,Taiki Sakaguchi,Ryu Okumura,Chisato Ono,Daisuke Okuzaki,Takafumi Kawai,Yoshifumi Okochi,Natsuko Tanimura,Mari Murakami,Hisako Kayama,Eiji Umemoto,Hidetaka Kioka,Tomohito Ohtani,Yasushi Sakata,Kensuke Miyake,Yasushi Okamura,Yoshihiro Baba,Kiyoshi Takeda,Cell reports,Vol. 31,No. 10,p. 107755-107755,2020年06月09日,研究論文(学術雑誌)
  • Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer.,Atsuyo Ikeda,Takayuki Ogino,Hisako Kayama,Daisuke Okuzaki,Junichi Nishimura,Shiki Fujino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hirofumi Yamamoto,Kiyoshi Takeda,Tsunekazu Mizushima,Masaki Mori,Yuichiro Doki,Cancer immunology research,Vol. 8,No. 6,p. 724-731,2020年06月,研究論文(学術雑誌)
  • Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine.,Hisako Kayama,Ryu Okumura,Kiyoshi Takeda,Annual review of immunology,Vol. 38,p. 23-48,2020年04月26日,研究論文(学術雑誌)
  • The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.,Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S Rangarajan,Kelly McKevitt,Amanda P Beck,Cody B Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious N Lacey,Gustavo J Martinez,Tina Izard,Robin G Lorenz,Alex Rodriguez-Palacios,Fabio Cominelli,Maria T Abreu,Daniel W Hommes,Sergei B Koralov,Kiyoshi Takeda,Mark S Sundrud,Immunity,Vol. 52,No. 3,p. 571-571,2020年03月17日
  • Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi.,Pareek S,Kurakawa T,Das B,Motooka D,Nakaya S,Rongsen-Chandola T,Goyal N,Kayama H,Dodd D,Okumura R,Maeda Y,Fujimoto K,Nii T,Ogawa T,Iida T,Bhandari N,Kida T,Nakamura S,Nair GB,Takeda K,NPJ biofilms and microbiomes,Vol. 5,p. 37-37,2019年12月,研究論文(学術雑誌)
  • BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway.,Hisako Kayama,Haruka Tani,Shoko Kitada,Anunya Opasawatchai,Ryu Okumura,Daisuke Motooka,Shota Nakamura,Kiyoshi Takeda,International immunology,Vol. 31,No. 6,p. 371-383,2019年05月21日,研究論文(学術雑誌)
  • Recasting the Tissue-Resident Lymphocyte in Celiac Disease.,Hisako Kayama,Kiyoshi Takeda,Immunity,Vol. 50,No. 3,p. 549-551,2019年03月19日,研究論文(学術雑誌)
  • GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.,Naoki Morita,Eiji Umemoto,Setsuko Fujita,Akio Hayashi,Junichi Kikuta,Ikuo Kimura,Takeshi Haneda,Toshio Imai,Asuka Inoue,Hitomi Mimuro,Yuichi Maeda,Hisako Kayama,Ryu Okumura,Junken Aoki,Nobuhiko Okada,Toshiyuki Kida,Masaru Ishii,Ryusuke Nabeshima,Kiyoshi Takeda,Nature,Vol. 566,No. 7742,p. 110-114,2019年02月,研究論文(学術雑誌)
  • Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients.,Yuki Sekido,Yoshiaki Yasumizu,Junichi Nishimura,Hisako Kayama,Hiroshi Matsuno,Takayuki Ogino,Norikatsu Miyoshi,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Yuichiro Doki,Masaki Mori,Kiyoshi Takeda,Naganari Ohkura,Shimon Sakaguchi,Tsunekazu Mizushima,Digestion,Vol. 99,No. 3,p. 194-204,2019年,研究論文(学術雑誌)
  • The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis.,Tadafumi Fukata,Tsunekazu Mizushima,Junichi Nishimura,Daisuke Okuzaki,Xin Wu,Haruka Hirose,Yuhki Yokoyama,Yui Kubota,Kazuya Nagata,Naoto Tsujimura,Akira Inoue,Norikatsu Miyoshi,Naotsugu Haraguchi,Hidekazu Takahashi,Taishi Hata,Chu Matsuda,Hisako Kayama,Kiyoshi Takeda,Yuichiro Doki,Masaki Mori,Hirofumi Yamamoto,Molecular therapy. Nucleic acids,Vol. 12,p. 658-671,2018年09月07日,研究論文(学術雑誌)
  • Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.,Hisako Kayama,Masako Kohyama,Daisuke Okuzaki,Daisuke Motooka,Soumik Barman,Ryu Okumura,Masato Muneta,Katsuaki Hoshino,Izumi Sasaki,Wataru Ise,Hiroshi Matsuno,Junichi Nishimura,Tomohiro Kurosaki,Shota Nakamura,Hisashi Arase,Tsuneyasu Kaisho,Kiyoshi Takeda,Proceedings of the National Academy of Sciences of the United States of America,Vol. 115,No. 33,p. 8418-8423,2018年08月14日,研究論文(学術雑誌)
  • The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.,Wei Cao,Hisako Kayama,Mei Lan Chen,Amber Delmas,Amy Sun,Sang Yong Kim,Erumbi S Rangarajan,Kelly McKevitt,Amanda P Beck,Cody B Jackson,Gogce Crynen,Angelos Oikonomopoulos,Precious N Lacey,Gustavo J Martinez,Tina Izard,Robin G Lorenz,Alex Rodriguez-Palacios,Fabio Cominelli,Maria T Abreu,Daniel W Hommes,Sergei B Koralov,Kiyoshi Takeda,Mark S Sundrud,Immunity,CELL PRESS,Vol. 47,No. 6,p. 1182-1196,2017年12月19日,研究論文(学術雑誌)
  • Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.,Kayo Ikeda,Makoto Kinoshita,Hisako Kayama,Shushi Nagamori,Pornparn Kongpracha,Eiji Umemoto,Ryu Okumura,Takashi Kurakawa,Mari Murakami,Norihisa Mikami,Yasunori Shintani,Satoko Ueno,Ayatoshi Andou,Morihiro Ito,Hideki Tsumura,Koji Yasutomo,Keiichi Ozono,Seiji Takashima,Shimon Sakaguchi,Yoshikatsu Kanai,Kiyoshi Takeda,Cell reports,CELL PRESS,Vol. 21,No. 7,p. 1824-1838,2017年11月14日,研究論文(学術雑誌)
  • CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis.,Hiroshi Matsuno,Hisako Kayama,Junichi Nishimura,Yuki Sekido,Hideki Osawa,Soumik Barman,Takayuki Ogino,Hidekazu Takahashi,Naotsugu Haraguchi,Taishi Hata,Chu Matsuda,Hirofumi Yamamoto,Motoi Uchino,Hiroki Ikeuchi,Yuichiro Doki,Masaki Mori,Kiyoshi Takeda,Tsunekazu Mizushima,Inflammatory bowel diseases,LIPPINCOTT WILLIAMS & WILKINS,Vol. 23,No. 9,p. 1524-1534,2017年09月,研究論文(学術雑誌)
  • BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.,Shoko Kitada,Hisako Kayama,Daisuke Okuzaki,Ritsuko Koga,Masao Kobayashi,Yasunobu Arima,Atsushi Kumanogoh,Masaaki Murakami,Masahito Ikawa,Kiyoshi Takeda,The Journal of experimental medicine,ROCKEFELLER UNIV PRESS,Vol. 214,No. 5,p. 1313-1331,2017年05月01日,研究論文(学術雑誌)
  • Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.,Kosuke Fujimoto,Makoto Kinoshita,Hiroo Tanaka,Daisuke Okuzaki,Yosuke Shimada,Hisako Kayama,Ryu Okumura,Yoki Furuta,Masashi Narazaki,Atsushi Tamura,Shigetsugu Hatakeyama,Masahito Ikawa,Kiichiro Tsuchiya,Mamoru Watanabe,Atsushi Kumanogoh,Sachiko Tsukita,Kiyoshi Takeda,Mucosal Immunol,Vol. 10,No. 2,p. 446-459,2017年03月,研究論文(学術雑誌)
  • Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186,Kosuke Fujimoto,Makoto Kinoshita,Hiroo Tanaka,Daisuke Okuzaki,Yosuke Shimada,Hisako Kayama,Ryu Okumura,Yoki Furuta,Masashi Narazaki,Atsushi Tamura,Shigetsugu Hatakeyama,Masahito Ikawa,Kiichiro Tsuchiya,Mamoru Watanabe,Atsushi Kumanogoh,Sachiko Tsukita,Kiyoshi Takeda,MUCOSAL IMMUNOLOGY,NATURE PUBLISHING GROUP,Vol. 10,No. 2,p. 446-459,2017年03月,研究論文(学術雑誌)
  • E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine,Yoki Furuta,Shih-Han Tsai,Makoto Kinoshita,Kosuke Fujimoto,Ryu Okumura,Eiji Umemoto,Yosuke Kurashima,Hiroshi Kiyono,Hisako Kayama,Kiyoshi Takeda,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 12,No. 2,2017年02月,研究論文(学術雑誌)
  • Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine,Yuichi Maeda,Takashi Kurakawa,Eiji Umemoto,Daisuke Motooka,Yoshinaga Ito,Kazuyoshi Gotoh,Keiji Hirota,Masato Matsushita,Yoki Furuta,Masashi Narazaki,Noriko Sakaguchi,Hisako Kayama,Shota Nakamura,Tetsuya Iida,Yukihiko Saeki,Atsushi Kumanogoh,Shimon Sakaguchi,Kiyoshi Takeda,ARTHRITIS & RHEUMATOLOGY,WILEY,Vol. 68,No. 11,p. 2646-2661,2016年11月,研究論文(学術雑誌)
  • Identification of a human intestinal myeloid cell subset that regulates gut homeostasis,Soumik Barman,Hisako Kayama,Daisuke Okuzaki,Takayuki Ogino,Hideki Osawa,Hiroshi Matsuno,Tsunekazu Mizushima,Masaki Mori,Junichi Nishimura,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 28,No. 11,p. 533-545,2016年11月,研究論文(学術雑誌)
  • IL-10-producing lung interstitial macrophages prevent neutrophilic asthma,Hideo Kawano,Hisako Kayama,Takekuni Nakama,Takashi Hashimoto,Eiji Umemoto,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 28,No. 10,p. 489-501,2016年10月,研究論文(学術雑誌)
  • Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia,Ryu Okumura,Takashi Kurakawa,Takashi Nakano,Hisako Kayama,Makoto Kinoshita,Daisuke Motooka,Kazuyoshi Gotoh,Taishi Kimura,Naganori Kamiyama,Takashi Kusu,Yoshiyasu Ueda,Hong Wu,Hideki Iijima,Soumik Barman,Hideki Osawa,Hiroshi Matsuno,Junichi Nishimura,Yusuke Ohba,Shota Nakamura,Tetsuya Iida,Masahiro Yamamoto,Eiji Umemoto,Koichi Sano,Kiyoshi Takeda,NATURE,NATURE PUBLISHING GROUP,Vol. 532,No. 7597,p. 117-+,2016年04月,研究論文(学術雑誌)
  • Functions of innate immune cells and commensal bacteria in gut homeostasis,Hisako Kayama,Kiyoshi Takeda,JOURNAL OF BIOCHEMISTRY,OXFORD UNIV PRESS,Vol. 159,No. 2,p. 141-149,2016年02月
  • Regulation of the human gut homeostasis by anti-inflammatory CD14+ CD163high CD160high myeloid cells,Hisako Kayama,Kiyoshi Takeda,Japanese Journal of Clinical Immunology,Japan Society for Clinical Immunology,Vol. 39,No. 5,p. 441-447,2016年,研究論文(学術雑誌)
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.,Kayama H,Ramirez-Carrozzi VR,Yamamoto M,Mizutani T,Kuwata H,Iba H,Matsumoto M,Honda K,Smale ST,Takeda K,The Journal of biological chemistry,Vol. 290,No. 37,p. 22446-22446,2015年09月
  • The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis,Ichino Chinen,Taisuke Nakahama,Akihiro Kimura,Nam T. Nguyen,Hiroshi Takemori,Ayako Kumagai,Hisako Kayama,Kiyoshi Takeda,Soyoung Lee,Hamza Hanieh,Barry Ripley,David Millrine,Praveen K. Dubey,Kishan K. Nyati,Yoshiaki Fujii-Kuriyama,Kamal Chowdhury,Tadamitsu Kishimoto,International Immunology,Oxford University Press,Vol. 27,No. 8,p. 405-415,2015年08月01日,研究論文(学術雑誌)
  • The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis,Ichino Chinen,Taisuke Nakahama,Akihiro Kimura,Nam T. Nguyen,Hiroshi Takemori,Ayako Kumagai,Hisako Kayama,Kiyoshi Takeda,Soyoung Lee,Hamza Hanieh,Barry Ripley,David Millrine,Praveen K. Dubey,Kishan K. Nyati,Yoshiaki Fujii-Kuriyama,Kamal Chowdhury,Tadamitsu Kishimoto,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 27,No. 8,p. 405-415,2015年08月,研究論文(学術雑誌)
  • The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.,Sato A,Kayama H,Shojima K,Matsumoto S,Koyama H,Minami Y,Nojima S,Morii E,Honda H,Takeda K,Kikuchi A,Scientific reports,Vol. 5,2015年06月,研究論文(学術雑誌)
  • The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells,Shih Han Tsai,Makoto Kinoshita,Takashi Kusu,Hisako Kayama,Ryu Okumura,Kayo Ikeda,Yosuke Shimada,Akira Takeda,Soichiro Yoshikawa,Kazushige Obata-Ninomiya,Yosuke Kurashima,Shintaro Sato,Eiji Umemoto,Hiroshi Kiyono,Hajime Karasuyama,Kiyoshi Takeda,Immunity,Cell Press,Vol. 42,No. 2,p. 279-293,2015年02月17日,研究論文(学術雑誌)
  • The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells,Shih Han Tsai,Makoto Kinoshita,Takashi Kusu,Hisako Kayama,Ryu Okumura,Kayo Ikeda,Yosuke Shimada,Akira Takeda,Soichiro Yoshikawa,Kazushige Obata-Ninomiya,Yosuke Kurashima,Shintaro Sato,Eiji Umemoto,Hiroshi Kiyono,Hajime Karasuyama,Kiyoshi Takeda,IMMUNITY,CELL PRESS,Vol. 42,No. 2,p. 279-293,2015年02月,研究論文(学術雑誌)
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.,Kayama H,Ramirez-Carrozzi VR,Yamamoto M,Mizutani T,Kuwata H,Iba H,Matsumoto M,Honda K,Smale ST,Takeda K,The Journal of biological chemistry,Vol. 290,No. 8,p. 4815-4815,2015年02月
  • Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation,Masanori Matsumoto,Akemi Baba,Takafumi Yokota,Hiroyoshi Nishikawa,Yasuyuki Ohkawa,Hisako Kayama,Axel Kallies,Stephen L. Nutt,Shimon Sakaguchi,Kiyoshi Takeda,Tomohiro Kurosaki,Yoshihiro Baba,IMMUNITY,CELL PRESS,Vol. 41,No. 6,p. 1040-1051,2014年12月,研究論文(学術雑誌)
  • Generation of colonic IgA-secreting cells in the caecal patch,Kazunori Masahata,Eiji Umemoto,Hisako Kayama,Manato Kotani,Shota Nakamura,Takashi Kurakawa,Junichi Kikuta,Kazuyoshi Gotoh,Daisuke Motooka,Shintaro Sato,Tomonori Higuchi,Yoshihiro Baba,Tomohiro Kurosaki,Makoto Kinoshita,Yosuke Shimada,Taishi Kimura,Ryu Okumura,Akira Takeda,Masaru Tajima,Osamu Yoshie,Masahiro Fukuzawa,Hiroshi Kiyono,Sidonia Fagarasan,Tetsuya Iida,Masaru Ishii,Kiyoshi Takeda,NATURE COMMUNICATIONS,NATURE PUBLISHING GROUP,Vol. 5,2014年04月,研究論文(学術雑誌)
  • Polysaccharide A of Bacteroides fragilis: Actions on Dendritic Cells and T Cells,Hisako Kayama,Kiyoshi Takeda,MOLECULAR CELL,CELL PRESS,Vol. 54,No. 2,p. 206-207,2014年04月
  • Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo.,Yokota K,Sato K,Miyazaki T,Kitaura H,Kayama H,Miyoshi F,Araki Y,Akiyama Y,Takeda K,Mimura T,Arthritis & rheumatology (Hoboken, N.J.),Vol. 66,No. 1,p. 121-129,2014年01月,研究論文(学術雑誌)
  • Increased Th17-Inducing Activity of CD14(+) CD163(low) Myeloid Cells in Intestinal Lamina Propria of Patients With Crohn's Disease,Takayuki Ogino,Junichi Nishimura,Soumik Barman,Hisako Kayama,Satoshi Uematsu,Daisuke Okuzaki,Hideki Osawa,Naotsugu Haraguchi,Mamoru Uemura,Taishi Hata,Ichiro Takemasa,Tsunekazu Mizushima,Hirofumi Yamamoto,Kiyoshi Takeda,Yuichiro Doki,Masaki Mori,GASTROENTEROLOGY,W B SAUNDERS CO-ELSEVIER INC,Vol. 145,No. 6,p. 1380-+,2013年12月,研究論文(学術雑誌)
  • Regulation of intestinal homeostasis by innate immune cells.,Kayama H,Nishimura J,Takeda K,Immune network,Vol. 13,No. 6,p. 227-234,2013年12月
  • Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon,Yosuke Shimada,Makoto Kinoshita,Kazuo Harada,Masafumi Mizutani,Kazunori Masahata,Hisako Kayama,Kiyoshi Takeda,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 8,No. 11,2013年11月,研究論文(学術雑誌)
  • Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5 ' Capped 2 '-O Unmethylated RNA,Taishi Kimura,Hiroshi Katoh,Hisako Kayama,Hiroyuki Saiga,Megumi Okuyama,Toru Okamoto,Eiji Umemoto,Yoshiharu Matsuura,Masahiro Yamamoto,Kiyoshi Takeda,JOURNAL OF VIROLOGY,AMER SOC MICROBIOLOGY,Vol. 87,No. 18,p. 9997-10003,2013年09月,研究論文(学術雑誌)
  • Recent advances in understanding the role of innate immunity in the pathogenesis of inflammatory bowel disease,Hisako Kayama,Kiyoshi Takeda,Journal of Japanese Society of Gastroenterology,Vol. 110,No. 5,p. 741-752,2013年05月
  • CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock,Naganori Kamiyama,Masahiro Yamamoto,Hiroyuki Saiga,Ji Su Ma,Jun Ohshima,Sakaaki Machimura,Miwa Sasai,Taishi Kimura,Yoshiyasu Ueda,Hisako Kayama,Kiyoshi Takeda,PLoS ONE,Vol. 8,No. 2,2013年02月07日,研究論文(学術雑誌)
  • Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine,Takashi Kusu,Hisako Kayama,Makoto Kinoshita,Seong Gyu Jeon,Yoshiyasu Ueda,Yoshiyuki Goto,Ryu Okumura,Hiroyuki Saiga,Takashi Kurakawa,Kayo Ikeda,Yuichi Maeda,Jun-ichi Nishimura,Yasunobu Arima,Koji Atarashi,Kenya Honda,Masaaki Murakami,Jun Kunisawa,Hiroshi Kiyono,Meinoshin Okumura,Masahiro Yamamoto,Kiyoshi Takeda,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 190,No. 2,p. 774-783,2013年01月,研究論文(学術雑誌)
  • Regulation of intestinal homeostasis by innate and adaptive immunity,Hisako Kayama,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 24,No. 11,p. 673-680,2012年11月
  • Dietary Folic Acid Promotes Survival of Foxp3(+) Regulatory T Cells in the Colon,Makoto Kinoshita,Hisako Kayama,Takashi Kusu,Tomoyuki Yamaguchi,Jun Kunisawa,Hiroshi Kiyono,Shimon Sakaguchi,Kiyoshi Takeda,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 189,No. 6,p. 2869-2878,2012年09月,研究論文(学術雑誌)
  • A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.,Yamamoto M,Okuyama M,Ma JS,Kimura T,Kamiyama N,Saiga H,Ohshima J,Sasai M,Kayama H,Okamoto T,Huang DC,Soldati-Favre D,Horie K,Takeda J,Takeda K,Immunity,Vol. 37,No. 2,p. 302-313,2012年08月,研究論文(学術雑誌)
  • Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon,Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda,PLOS PATHOGENS,PUBLIC LIBRARY SCIENCE,Vol. 8,No. 5,2012年05月,研究論文(学術雑誌)
  • Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon,Seong Gyu Jeon,Hisako Kayama,Yoshiyasu Ueda,Takuya Takahashi,Takashi Asahara,Hirokazu Tsuji,Noriko M. Tsuji,Hiroshi Kiyono,Ji Su Ma,Takashi Kusu,Ryu Okumura,Hiromitsu Hara,Hiroki Yoshida,Masahiro Yamamoto,Koji Nomoto,Kiyoshi Takeda,PLoS Pathogens,Vol. 8,No. 5,2012年05月,研究論文(学術雑誌)
  • Intestinal CX3C chemokine receptor 1(high) (CX(3)CR1(high)) myeloid cells prevent T-cell-dependent colitis,Hisako Kayama,Yoshiyasu Ueda,Yukihisa Sawa,Seong Gyu Jeon,Ji Su Ma,Ryu Okumura,Atsuko Kubo,Masaru Ishii,Taku Okazaki,Masaaki Murakami,Masahiro Yamamoto,Hideo Yagita,Kiyoshi Takeda,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,NATL ACAD SCIENCES,Vol. 109,No. 13,p. 5010-5015,2012年03月,研究論文(学術雑誌)
  • The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells,Kazushiro Takata,Makoto Kinoshita,Tatsusada Okuno,Masayuki Moriya,Tohru Kohda,Josephe A. Honorat,Tomoyuki Sugimoto,Atsushi Kumanogoh,Hisako Kayama,Kiyoshi Takeda,Saburo Sakoda,Yuji Nakatsuji,PLOS ONE,PUBLIC LIBRARY SCIENCE,Vol. 6,No. 11,2011年11月,研究論文(学術雑誌)
  • ATF6 beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18,Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda,JOURNAL OF EXPERIMENTAL MEDICINE,ROCKEFELLER UNIV PRESS,Vol. 208,No. 7,p. 1533-1546,2011年07月,研究論文(学術雑誌)
  • Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10,Yoshiyasu Ueda,Hisako Kayama,Seong Gyu Jeon,Takashi Kusu,Yoshitaka Isaka,Hiromi Rakugi,Masahiro Yamamoto,Kiyoshi Takeda,INTERNATIONAL IMMUNOLOGY,OXFORD UNIV PRESS,Vol. 22,No. 12,p. 953-962,2010年12月,研究論文(学術雑誌)
  • The innate immune response to Trypanosoma cruzi infection,Hisako Kayama,Kiyoshi Takeda,MICROBES AND INFECTION,ELSEVIER SCIENCE BV,Vol. 12,No. 7,p. 511-517,2010年07月
  • A novel in vivo inducible dendritic cell ablation model in mice,Megumi Okuyama,Hisako Kayama,Koji Atarashi,Hiroyuki Saiga,Taishi Kimura,Ari Waisman,Masahiro Yamamoto,Kiyoshi Takeda,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 397,No. 3,p. 559-563,2010年07月,研究論文(学術雑誌)
  • A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3,Masahiro Yamamoto,Daron M. Standley,Seiji Takashima,Hiroyuki Saiga,Megumi Okuyama,Hisako Kayama,Emi Kubo,Hiroshi Ito,Mutsumi Takaura,Tadashi Matsuda,Dominique Soldati-Favre,Kiyoshi Takeda,JOURNAL OF EXPERIMENTAL MEDICINE,ROCKEFELLER UNIV PRESS,Vol. 206,No. 12,p. 2747-2760,2009年11月,研究論文(学術雑誌)
  • NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Infection,Hisako Kayama,Ritsuko Koga,Koji Atarashi,Megumi Okuyama,Taishi Kimura,Tak W. Mak,Satoshi Uematsu,Shizuo Akira,Hiroshi Takayanagi,Kenya Honda,Masahiro Yamamoto,Kiyoshi Takeda,PLOS PATHOGENS,PUBLIC LIBRARY SCIENCE,Vol. 5,No. 7,2009年07月,研究論文(学術雑誌)
  • Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses.,Hideaki Morishita,Fumiji Saito,Hisako Kayama,Koji Atarashi,Hirotaka Kuwata,Masahiro Yamamoto,Kiyoshi Takeda,International immunology,Vol. 21,No. 4,p. 457-65,2009年04月,研究論文(学術雑誌)
  • Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I kappa B zeta,Hisako Kayama,Vladimir R. Ramirez-Carrozzi,Masahiro Yamamoto,Taketoshi Mizutani,Hirotaka Kuwata,Hideo Iba,Makoto Matsumoto,Kenya Honda,Stephen T. Smale,Kiyoshi Takeda,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 283,No. 18,p. 12468-12477,2008年05月,研究論文(学術雑誌)
  • Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor,Junichi Nishimura,Hiroyuki Saiga,Shintaro Sato,Megumi Okuyama,Hisako Kayama,Hirotaka Kuwata,Sohkichi Matsumoto,Toshirou Nishida,Yoshiki Sawa,Shizuo Akira,Yasunobu Yoshikai,Masahiro Yamamoto,Kiyoshi Takeda,JOURNAL OF IMMUNOLOGY,AMER ASSOC IMMUNOLOGISTS,Vol. 180,No. 6,p. 4032-4039,2008年03月,研究論文(学術雑誌)

MISC

  • Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn's disease patients versus mucus.,Yuki Sekido,Junichi Nishimura,Kazuhiro Nakano,Takeaki Osu,Cheryl-Emiliane T Chow,Hiroshi Matsuno,Takayuki Ogino,Shiki Fujino,Norikatsu Miyoshi,Hidekazu Takahashi,Mamoru Uemura,Chu Matsuda,Hisako Kayama,Masaki Mori,Yuichiro Doki,Kiyoshi Takeda,Motoi Uchino,Hiroki Ikeuchi,Tsunekazu Mizushima,Scientific reports,Vol. 10,No. 1,p. 2988-2988,2020年02月19日
  • Dietary iron and transcription factor Spi-C regulate gut homeostasis through maintenance of CX(3)CR1(high) CD11b(+) CD11c(+) cells,H. Kayama,M. Kohyama,H. Arase,K. Takeda,EUROPEAN JOURNAL OF IMMUNOLOGY,WILEY-BLACKWELL,Vol. 46,p. 470-470,2016年08月,研究発表ペーパー・要旨(国際会議)
  • がん微小環境における代謝と免疫応答 (第5土曜特集 がん標的分子と治療開発 : 現状と将来) -- (がん免疫研究をめぐる最新の動向),香山 尚子,竹田 潔,医学のあゆみ,医歯薬出版,Vol. 258,No. 5,p. 451-454,2016年07月30日
  • Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析,佐藤 朗,香山 尚子,庄嶋 健作,松本 真司,小山 浩史,南 康博,野島 聡,森井 英一,本田 浩章,竹田 潔,菊池 章,日本生化学会大会・日本分子生物学会年会合同大会講演要旨集,(公社)日本生化学会,Vol. 88回・38回,p. [1P0170]-[1P0170],2015年12月
  • Wnt5a-Ror2シグナルによる腸管炎症の増悪機構の解析,佐藤 朗,香山 尚子,庄嶋 健作,松本 真司,小山 浩史,南 康博,野島 聡,森井 英一,本田 浩章,竹田 潔,菊池 章,日本生化学会大会プログラム・講演要旨集,(公社)日本生化学会,Vol. 87回,p. [2T09p-07],2014年10月
  • 免疫応答の負の制御:免疫恒常性の維持と疾患治療への応用 自然免疫細胞による腸管免疫制御,香山尚子,西村潤一,竹田潔,細胞工学,Vol. 32,No. 12,p. 1205-1210,2013年11月22日
  • 自然免疫細胞による腸管粘膜免疫系の制御 (AYUMI 生活習慣病におけるマクロファージ),香山 尚子,竹田 潔,医学のあゆみ,医歯薬出版,Vol. 246,No. 11,p. 954-959,2013年09月14日
  • 自然免疫系を標的とした炎症性腸疾患の制御 (特集 最新の免疫学 : 自然免疫・獲得免疫),梅本 英司,香山 尚子,竹田 潔,医薬ジャーナル,医薬ジャーナル社,Vol. 49,No. 2,p. 79-84,2013年02月
  • Wnt5aノックアウトマウスにおける腸管炎症の抑制,佐藤朗,庄嶋健作,香山尚子,小山浩史,竹田潔,菊池章,日本分子生物学会年会プログラム・要旨集(Web),Vol. 36th,2013年

特許・実用新案・意匠

  • 腸内細菌数低減剤,特願2021-50445
  • 炎症性腸疾患を検査する方法,特願2021-48492
  • 炎症性腸疾患治療用組成物,特願2021-48468

受賞

  • 第15回日本免疫学会研究研究奨励賞,2020年12月
  • 令和2年度大阪大学賞若手研究員部門,2020年12月