EN

基本情報

研究

社会活動

その他の活動

古賀 雄一

Koga Yuuichi

工学研究科 生物工学専攻,准教授

keyword 極限環境微微生物,進化,酵素,超好熱菌,古細菌(始原菌),タンパク質工学

研究内容・専門分野

  • ライフサイエンス,応用生物化学

所属学会

  • 日本生物工学会

論文

  • Insertion loop-mediated folding propagation governs efficient maturation of hyperthermophilic Tk-subtilisin at high temperatures.,Ryo Uehara,Nanako Dan,Hiroshi Amesaka,Takuya Yoshizawa,Yuichi Koga,Shigenori Kanaya,Kazufumi Takano,Hiroyoshi Matsumura,Shun-Ichi Tanaka,FEBS letters,Vol. 595,No. 4,p. 452-461,2021年02月,研究論文(学術雑誌)
  • Affinity shift of ATP upon glycerol binding to a glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1.,Ryuta Hokao,Hiroyoshi Matsumura,Ryota Katsumi,Clement Angkawidjaja,Kazufumi Takano,Shigenori Kanaya,Yuichi Koga,Journal of bioscience and bioengineering,Vol. 129,No. 6,p. 657-663,2020年06月,研究論文(学術雑誌)
  • Characterization of Chinese hamster lung (CHL) cell lines, focusing on gene expression analysis,Rintaro Arishima,Noriko Yamano-Adachi,Yuichi Koga,Takeshi Omasa,2019年11月
  • Anaerobic glycerol-3-phosphate dehydrogenase complex from hyperthermophilic archaeon Thermococcus kodakarensis KOD1.,Yuichi Koga,Kanako Konishi,Atsushi Kobayashi,Shigenori Kanaya,Kazufumi Takano,Journal of bioscience and bioengineering,Vol. 127,No. 6,p. 679-685,2019年06月,研究論文(学術雑誌)
  • Secretion analysis of intracellular “difficult-to-express” immunoglobulin G (IgG) in Chinese hamster ovary (CHO) cells,Kohei Kaneyoshi,Kouki Kuroda,Keiji Uchiyama,Masayoshi Onitsuka,Noriko Yamano-Adachi,Yuichi Koga,Takeshi Omasa,Cytotechnology,Vol. 71,No. 1,p. 305-316,2019年02月,研究論文(学術雑誌)
  • Analysis of the immunoglobulin G (IgG) secretion efficiency in recombinant Chinese hamster ovary (CHO) cells by using Citrine-fusion IgG,Kohei Kaneyoshi,Noriko Yamano-Adachi,Yuichi Koga,Keiji Uchiyama,Takeshi Omasa,Cytotechnology,Vol. 71,No. 1,p. 193-207,2019年02月,研究論文(学術雑誌)
  • Analysis of intracellular IgG secretion in Chinese hamster ovary cells to improve IgG production.,Kohei Kaneyoshi,Keiji Uchiyama,Masayoshi Onitsuka,Noriko Yamano,Yuichi Koga,Takeshi Omasa,Journal of Bioscience and Bioengineering,Vol. 127,No. 1,p. 107-113,2019年01月,研究論文(学術雑誌)
  • Quantitative analysis of intracellular secretion of recombinant antibodies in CHO cells for establishment of high producers,Kouki Kuroda,Kohei Kaneyoshi,Noriko Yamano,Yuichi Koga,Takeshi Omasa,2018年11月
  • Characterization of CHO cells with disparate chromosome numbers and induction of artificial aneuploidy cells,Noriko Yamano,Norichika Ogata,Yuan Shan Lai,Sho Tanaka,Wataru Tanaka,Yuichi Koga,Takeshi Omasa,2018年11月
  • Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain.,Daichi Murata,Hiroyuki Okano,Clement Angkawidjaja,Masato Akutsu,Shun-Ichi Tanaka,Kenyu Kitahara,Takuya Yoshizawa,Hiroyoshi Matsumura,Yuji Kado,Eiichi Mizohata,Tsuyoshi Inoue,Satoshi Sano,Yuichi Koga,Shigenori Kanaya,Kazufumi Takano,Biochemistry,AMER CHEMICAL SOC,Vol. 56,No. 47,p. 6281-6291,2017年11月28日,研究論文(学術雑誌)
  • Hyperthermophilic Subtilisin-Like Proteases From Thermococcus kodakarensis,Uehara R,Takano K,Kanaya S,Koga Y,Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications,p. 81-117,2016年
  • Effects of surfactant and a hyperthermostable protease on infectivity of Scrapie-infected mouse brain homogenate.,Hirata A,Sakudo A,Takano K,Kanaya S,Koga Y,Journal of Biotechnol and Biomater,2015年07月,研究論文(学術雑誌)
  • Proteolysis of Abnormal Prion Protein with a Thermostable Protease from a Hyper-Thermophilic Archaeon Thermococcus Kodakarensis Kod1,Koga Yuichi,Shimizu Nami,Sakudo Akikazu,Kanaya Shigenori,BIOPHYSICAL JOURNAL,Vol. 108,No. 2,2015年01月27日
  • Enzyme immobilization on gold/Fe-oxide composite nanoparticles using a methionine tag,Satoshi Seino,Kazuma Watanabe,Toshihiro Shikakura,Michika Abe,Takashi Nakagawa,Yuichi Koga,Takao A. Yamamoto,COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,ELSEVIER SCIENCE BV,Vol. 459,p. 298-301,2014年10月,研究論文(学術雑誌)
  • Structural basis for salt-dependent folding of ribonuclease H1 from halophilic archaeon Halobacterium sp. NRC-1.,Dong-Ju You,Nujarin Jongruja,Elias Tannous,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,Journal of structural biology,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 187,No. 2,p. 119-128,2014年08月,研究論文(学術雑誌)
  • Calcium-independent opening of lid1 of a family I.3 lipase by a single Asp to Arg mutation at the calcium-binding site.,M Cheng,C Angkawidjaja,Y Koga,S Kanaya,Protein engineering, design & selection : PEDS,OXFORD UNIV PRESS,Vol. 27,No. 5,p. 169-76,2014年05月,研究論文(学術雑誌)
  • Crystal structure and thermodynamic and kinetic stability of metagenome-derived LC-cutinase.,Sintawee Sulaiman,Dong-Ju You,Eiko Kanaya,Yuichi Koga,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 53,No. 11,p. 1858-69,2014年03月25日,研究論文(学術雑誌)
  • Proteolysis of abnormal prion protein with a thermostable protease from Thermococcus kodakarensis KOD1.,Yuichi Koga,Shun-ichi Tanaka,Akikazu Sakudo,Minoru Tobiume,Mutsuo Aranishi,Azumi Hirata,Kazufumi Takano,Kazuyoshi Ikuta,Shigenori Kanaya,Applied microbiology and biotechnology,SPRINGER,Vol. 98,No. 5,p. 2113-20,2014年03月,研究論文(学術雑誌)
  • Control the Functionality of Thermoresponsive Enzymes Immobilized onto Magnetic Nanoparticles by the Application of Alternating Magnetic Field.,Seino S,Yoshida K,Shikakura T,Watnabe K,Koga Y,Nakagawa T,Yamamoto T. A,J. Mag. Soc. J.,2014年03月,研究論文(学術雑誌)
  • Structural and mechanistic insights into the kynurenine aminotransferase-mediated excretion of kynurenic acid.,Ken Okada,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,Journal of structural biology,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 185,No. 3,p. 257-66,2014年03月,研究論文(学術雑誌)
  • Structure and stability of metagenome-derived glycoside hydrolase family 12 cellulase (LC-CelA) a homolog of Cel12A from Rhodothermus marinus.,Hiroyuki Okano,Masashi Ozaki,Eiko Kanaya,Joong-Jae Kim,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,FEBS open bio,ELSEVIER SCIENCE LONDON,Vol. 4,p. 936-46,2014年,研究論文(学術雑誌)
  • Formation of the high-affinity calcium binding site in pro-subtilisin E with the insertion sequence IS1 of pro-Tk-subtilisin.,Ryo Uehara,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 52,No. 50,p. 9080-8,2013年12月17日,研究論文(学術雑誌)
  • Increase in activation rate of Pro-Tk-subtilisin by a single nonpolar-to-polar amino acid substitution at the hydrophobic core of the propeptide domain.,Kota Yuzaki,Yudai Sanda,Dong-Ju You,Ryo Uehara,Yuichi Koga,Shigenori Kanaya,Protein science : a publication of the Protein Society,WILEY-BLACKWELL,Vol. 22,No. 12,p. 1711-21,2013年12月,研究論文(学術雑誌)
  • Role of N-terminal extension of Bacillus stearothermophilus RNase H2 and C-terminal extension of Thermotoga maritima RNase H2.,Etin-Diah Permanasari,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,The FEBS journal,WILEY-BLACKWELL,Vol. 280,No. 20,p. 5065-79,2013年10月,研究論文(学術雑誌)
  • Evolvability of thermophilic proteins from archaea and bacteria.,Kazufumi Takano,Atsushi Aoi,Yuichi Koga,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 52,No. 28,p. 4774-80,2013年07月16日,研究論文(学術雑誌)
  • Crystal structure of metagenome-derived LC9-RNase H1 with atypical DEDN active site motif.,Tri-Nhan Nguyen,Dong-Ju You,Eiko Kanaya,Yuichi Koga,Shigenori Kanaya,FEBS letters,Vol. 587,No. 9,p. 1418-23,2013年05月02日,研究論文(学術雑誌)
  • Crystal structure of metagenome-derived LC11-RNase H1 in complex with RNA/DNA hybrid.,Tri-Nhan Nguyen,Dong-Ju You,Hiroyuki Matsumoto,Eiko Kanaya,Yuichi Koga,Shigenori Kanaya,Journal of structural biology,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 182,No. 2,p. 144-54,2013年05月,研究論文(学術雑誌)
  • Investigating the structural dependence of protein stabilization by amino acid substitution.,Takashi Tadokoro,Hirotaka Kazama,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 52,No. 16,p. 2839-47,2013年04月23日,研究論文(学術雑誌)
  • Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakarensis in detergents and its ability to degrade the abnormal prion protein.,Azumi Hirata,Yuki Hori,Yuichi Koga,Jun Okada,Akikazu Sakudo,Kazuyoshi Ikuta,Shigenori Kanaya,Kazufumi Takano,BMC biotechnology,Vol. 13,p. 19-19,2013年02月28日,研究論文(学術雑誌)
  • Accelerated maturation of Tk-subtilisin by a Leu→Pro mutation at the C-terminus of the propeptide, which reduces the binding of the propeptide to Tk-subtilisin.,Cheng M,Angkawidjaja C,Koga Y,Kanaya S,FEBS J.,,WILEY-BLACKWELL,Vol. 280,No. 4,p. 994-1006,2013年02月,研究論文(学術雑誌)
  • Heparanase localization during palatogenesis in mice,Hirata A,Katayama K,Tsuji T,Natsume N,Sugahara T,Koga Y,Takano K,Otsuki Y,Nakamura H,BioMed Research International,Vol. 2013,2013年
  • Slow unfolding pathway of hyperthermophilic Tk-RNase H2 examined by pulse proteolysis using the stable protease Tk-subtilisin.,Jun Okada,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,Vol. 51,No. 45,p. 9178-91,2012年11月13日,研究論文(学術雑誌)
  • Requirement of insertion sequence IS1 for thermal adaptation of Pro-Tk-subtilisin from hyperthermophilic archaeon.,Ryo Uehara,Shun-Ichi Tanaka,Kazufumi Takano,Yuichi Koga,Shigenori Kanaya,Extremophiles : life under extreme conditions,SPRINGER JAPAN KK,Vol. 16,No. 6,p. 841-51,2012年11月,研究論文(学術雑誌)
  • Requirement of lid2 for interfacial activation of a family I.3 lipase with unique two lid structures.,Maria Cheng,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,The FEBS journal,WILEY-BLACKWELL,Vol. 279,No. 19,p. 3727-3737,2012年10月,研究論文(学術雑誌)
  • Structure and stability of a thermostable carboxylesterase from the thermoacidophilic archaeon Sulfolobus tokodaii.,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,Vol. 279,No. 17,p. 3071-84,2012年09月,研究論文(学術雑誌)
  • Flavobacterium compostarboris sp. nov., isolated from leaf-and-branch compost, and emended descriptions of Flavobacterium hercynium, Flavobacterium resistens and Flavobacterium johnsoniae.,Joong-Jae Kim,Eiko Kanaya,Hang-Yeon Weon,Yuichi Koga,Kazufumi Takano,Peter F Dunfield,Soon-Wo Kwon,Shigenori Kanaya,International journal of systematic and evolutionary microbiology,Vol. 62,No. Pt 8,p. 2018-2024,2012年08月,研究論文(学術雑誌)
  • Structure and characterization of RNase H3 from Aquifex aeolicus.,Nujarin Jongruja,Dong-Ju You,Clement Angkawidjaja,Eiko Kanaya,Yuichi Koga,Shigenori Kanaya,The FEBS journal,WILEY-BLACKWELL,Vol. 279,No. 15,p. 2737-53,2012年08月,研究論文(学術雑誌)
  • Requirement of Ca(2+) ions for the hyperthermostability of Tk-subtilisin from Thermococcus kodakarensis.,Ryo Uehara,Yuki Takeuchi,Shun-ichi Tanaka,Kazufumi Takano,Yuichi Koga,Shigenori Kanaya,Biochemistry,Vol. 51,No. 26,p. 5369-78,2012年07月03日,研究論文(学術雑誌)
  • Degradation of abnormal prion protein by a hyper-stable protease,Kazufumi Takano,Yuki Hori,Azumi Hirata,Yuichi Koga,Akikazu Sakudo,Kazuyoshi Ikuta,Shigenori Kanaya,PRION,LANDES BIOSCIENCE,Vol. 6,p. 139-139,2012年04月
  • Activity, stability, and structure of metagenome-derived LC11-RNase H1, a homolog of Sulfolobus tokodaii RNase H1.,Tri-Nhan Nguyen,Clement Angkawidjaja,Eiko Kanaya,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Protein science : a publication of the Protein Society,Vol. 21,No. 4,p. 553-61,2012年04月,研究論文(学術雑誌)
  • Role of polar and nonpolar residues at the active site for PPIase activity of FKBP22 from Shewanella sp. SIB1.,Cahyo Budiman,Takashi Tadokoro,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,The FEBS journal,Vol. 279,No. 6,p. 976-86,2012年03月,研究論文(学術雑誌)
  • Isolation of a novel cutinase homolog with polyethylene terephthalate-degrading activity from leaf-branch compost by using a metagenomic approach.,Sintawee Sulaiman,Saya Yamato,Eiko Kanaya,Joong-Jae Kim,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Applied and environmental microbiology,Vol. 78,No. 5,p. 1556-62,2012年03月,研究論文(学術雑誌)
  • A dual role of divalent metal ions in catalysis and folding of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1.,Elias Tannous,Koji Yokoyama,Dong-Ju You,Yuichi Koga,Shigenori Kanaya,FEBS open bio,ELSEVIER SCIENCE LONDON,Vol. 2,p. 345-52,2012年,研究論文(学術雑誌)
  • Characteristic features of kynurenine aminotransferase allosterically regulated by (alpha)-ketoglutarate in cooperation with kynurenine.,Ken Okada,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,PloS one,Vol. 7,No. 7,2012年,研究論文(学術雑誌)
  • Crystal structure of N-domain of FKBP22 from Shewanella sp. SIB1: dimer dissociation by disruption of Val-Leu knot.,Cahyo Budiman,Clement Angkawidjaja,Hideki Motoike,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Protein science : a publication of the Protein Society,Vol. 20,No. 10,p. 1755-64,2011年10月,研究論文(学術雑誌)
  • Identification of the substrate binding site in the N-terminal TBP-like domain of RNase H3.,Seiko Miyashita,Takashi Tadokoro,Clement Angkawidjaja,Dong-Ju You,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS letters,Vol. 585,No. 14,p. 2313-7,2011年07月21日,研究論文(学術雑誌)
  • Flavobacterium banpakuense sp. nov., isolated from leaf-and-branch compost.,Joong-Jae Kim,Hyun Mi Jin,Hyo Jung Lee,Che Ok Jeon,Eiko Kanaya,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,International journal of systematic and evolutionary microbiology,Vol. 61,No. Pt 7,p. 1595-1600,2011年07月,研究論文(学術雑誌)
  • An alternative mature form of subtilisin homologue, Tk-SP, from Thermococcus kodakaraensis identified in the presence of Ca2+.,Nitat Sinsereekul,Tita Foophow,Mai Yamanouchi,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,Vol. 278,No. 11,p. 1901-11,2011年06月,研究論文(学術雑誌)
  • Importance of an extreme C-terminal motif of a family I.3 lipase for stability.,K Kuwahara,C Angkawidjaja,Y Koga,K Takano,S Kanaya,Protein engineering, design & selection : PEDS,Vol. 24,No. 5,p. 411-8,2011年05月,研究論文(学術雑誌)
  • Laser-induced nucleation in protein crystallization: Local increase in protein concentration induced by femtosecond laser irradiation,Natsuko Iefuji,Ryota Murai,Mihoko Maruyama,Yoshinori Takahashi,Shigeru Sugiyama,Hiroaki Adachi,Hiroyoshi Matsumura,Satoshi Murakami,Tsuyoshi Inoue,Yusuke Mori,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF CRYSTAL GROWTH,ELSEVIER SCIENCE BV,Vol. 318,No. 1,p. 741-744,2011年03月,研究論文(学術雑誌)
  • Inhibition of chymotrypsin- and subtilisin-like serine proteases with Tk-serpin from hyperthermophilic archaeon Thermococcus kodakaraensis.,Shun-ichi Tanaka,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochimica et biophysica acta,Vol. 1814,No. 2,p. 299-307,2011年02月,研究論文(学術雑誌)
  • Stabilization by fusion to the C-terminus of hyperthermophile Sulfolobus tokodaii RNase HI: a possibility of protein stabilization tag.,Kazufumi Takano,Tomohiro Okamoto,Jun Okada,Shun-ichi Tanaka,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,PloS one,Vol. 6,No. 1,2011年01月19日,研究論文(学術雑誌)
  • FK506-Binding protein 22 from a psychrophilic bacterium, a cold shock-inducible peptidyl prolyl isomerase with the ability to assist in protein folding.,Cahyo Budiman,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,International journal of molecular sciences,Vol. 12,No. 8,p. 5261-84,2011年,研究論文(学術雑誌)
  • Crystal structure of stable protein CutA1 from psychrotrophic bacterium Shewanella sp. SIB1.,Aya Sato,Sonoko Yokotani,Takashi Tadokoro,Shun-ichi Tanaka,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of synchrotron radiation,WILEY-BLACKWELL PUBLISHING, INC,Vol. 18,No. 1,p. 6-10,2011年01月,研究論文(学術雑誌)
  • The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity.,Nujarin Jongruja,Dong-Ju You,Eiko Kanaya,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,Vol. 277,No. 21,p. 4474-89,2010年11月,研究論文(学術雑誌)
  • Protein core adaptability: crystal structures of the cavity-filling variants of Escherichia coli RNase HI.,Masaki Tanaka,Hyongi Chon,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Protein and peptide letters,Vol. 17,No. 9,p. 1163-9,2010年09月,研究論文(学術雑誌)
  • Cloning of the RNase H genes from a metagenomic DNA library: identification of a new type 1 RNase H without a typical active-site motif.,E Kanaya,T Sakabe,N T Nguyen,S Koikeda,Y Koga,K Takano,S Kanaya,Journal of applied microbiology,Vol. 109,No. 3,p. 974-83,2010年09月,研究論文(学術雑誌)
  • Crystal structure of a subtilisin homologue, Tk-SP, from thermococcus kodakaraensis: Requirement of a C-terminal β-Jelly Roll domain for hyperstability,Foophow T,Tanaka S.-I,Angkawidjaja C,Koga Y,Takano K,Kanaya S,Journal of Molecular Biology,Vol. 400,No. 4,p. 865-77,2010年07月23日,研究論文(学術雑誌)
  • Evolution and thermodynamics of the slow unfolding of hyperstable monomeric proteins.,Jun Okada,Tomohiro Okamoto,Atsushi Mukaiyama,Takashi Tadokoro,Dong-Ju You,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,BMC evolutionary biology,Vol. 10,No. 1,p. 207-207,2010年07月09日,研究論文(学術雑誌)
  • X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids.,Clement Angkawidjaja,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of molecular biology,Vol. 400,No. 1,p. 82-95,2010年07月02日,研究論文(学術雑誌)
  • Degradation of Abnormal Prion Protein by a New Protease from a Hyperthermophile,Koga Yuichi,Tanaka Shun-ichi,Sakudo Akikazu,Ikuta Kazuyoshi,Takano Kazufumi,Kanaya Shigenori,PRION,Vol. 4,No. 3,2010年07月
  • Subtilisin-like serine protease from hyperthermophilic archaeon Thermococcus kodakaraensis with N- and C-terminal propeptides.,T Foophow,S Tanaka,Y Koga,K Takano,S Kanaya,Protein engineering, design & selection : PEDS,Vol. 23,No. 5,p. 347-55,2010年05月,研究論文(学術雑誌)
  • Identification of the interactions critical for propeptide-catalyzed folding of Tk-subtilisin.,Shun-ichi Tanaka,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of molecular biology,Vol. 394,No. 2,p. 306-19,2009年11月27日,研究論文(学術雑誌)
  • Requirement of a unique Ca(2+)-binding loop for folding of Tk-subtilisin from a hyperthermophilic archaeon.,Yuki Takeuchi,Shun-ichi Tanaka,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,Vol. 48,No. 44,p. 10637-43,2009年11月10日,研究論文(学術雑誌)
  • Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate.,Cahyo Budiman,Keisuke Bando,Clement Angkawidjaja,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,Vol. 276,No. 15,p. 4091-101,2009年08月,研究論文(学術雑誌)
  • Proline effect on the thermostability and slow unfolding of a hyperthermophilic protein.,Kazufumi Takano,Ryogo Higashi,Jun Okada,Atsushi Mukaiyama,Takashi Tadokoro,Yuichi Koga,Shigenori Kanaya,Journal of biochemistry,Vol. 145,No. 1,p. 79-85,2009年01月,研究論文(学術雑誌)
  • Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses.,Muhammad S Rohman,Takashi Tadokoro,Clement Angkawidjaja,Yumi Abe,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,Vol. 276,No. 2,p. 603-13,2009年01月,研究論文(学術雑誌)
  • Importance of the Ca2+-binding sites in the N-catalytic domain of a family I.3 lipase for activity and stability.,K Kuwahara,C Angkawidjaja,H Matsumura,Y Koga,K Takano,S Kanaya,Protein engineering, design & selection : PEDS,Vol. 21,No. 12,p. 737-44,2008年12月,研究論文(学術雑誌)
  • Crystal structure of Tk-subtilisin folded without propeptide: requirement of propeptide for acceleration of folding.,Shun-ichi Tanaka,Yuki Takeuchi,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS letters,Vol. 582,No. 28,p. 3875-8,2008年11月26日,研究論文(学術雑誌)
  • Osmolyte effect on the stability and folding of a hyperthermophilic protein,Atsushi Mukaiyama,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,WILEY-LISS,Vol. 71,No. 1,p. 110-118,2008年04月,研究論文(学術雑誌)
  • Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation.,Clement Angkawidjaja,Dong-ju You,Hiroyoshi Matsumura,Katsumasa Kuwahara,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS letters,ELSEVIER SCIENCE BV,Vol. 581,No. 26,p. 5060-4,2007年10月30日,研究論文(学術雑誌)
  • Crystallization and preliminary X-ray diffraction study of glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakaraensis.,Ryota Katsumi,Yuichi Koga,Dong-Ju You,Hiroyoshi Matsumura,Kazufumi Takano,Shigenori Kanaya,Acta crystallographica. Section F, Structural biology and crystallization communications,Vol. 63,No. Pt 2,p. 126-9,2007年02月01日,研究論文(学術雑誌)
  • A hyperthermophilic protein acquires function at the cost of stability,Atsushi Mukaiyama,Mitsuru Haruki,Motonori Ota,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,BIOCHEMISTRY,AMER CHEMICAL SOC,Vol. 45,No. 42,p. 12673-12679,2006年10月,研究論文(学術雑誌)
  • Crystallization and preliminary crystallographic analysis of type 1 RNase H from the hyperthermophilic archaeon Sulfolobus tokodaii 7.,Dong Ju You,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Acta crystallographica. Section F, Structural biology and crystallization communications,Vol. 62,No. Pt 8,p. 781-4,2006年08月01日,研究論文(学術雑誌)
  • Crystallization and preliminary X-ray diffraction study of active-site mutant of pro-Tk-subtilisin from a hyperthermophilic archaeon.,Tanaka S,Saito K,Chon H,Matsumura H,Koga Y,Takano K,Kanaya S,Acta. Cryst. F,2006年08月,研究論文(学術雑誌)
  • Extracellular secretion of Escherichia coli alkaline phosphatase with a C-terminal tag by type I secretion system: purification and biochemical characterization.,C Angkawidjaja,K Kuwahara,K Omori,Y Koga,K Takano,S Kanaya,Protein engineering, design & selection : PEDS,OXFORD UNIV PRESS,Vol. 19,No. 7,p. 337-43,2006年07月,研究論文(学術雑誌)
  • Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 angstrom resolution,H Chon,H Matsumura,Y Koga,K Takano,S Kanaya,PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,WILEY-LISS,Vol. 61,No. 3,p. 685-688,2005年11月,研究論文(学術雑誌)
  • Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3.,Hyongi Chon,Hiroyoshi Matsumura,Shoko Shimizu,Nao Maeda,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Acta crystallographica. Section F, Structural biology and crystallization communications,Vol. 61,No. Pt 3,p. 319-22,2005年03月01日,研究論文(学術雑誌)
  • Improvement in corrected QT dispersion by physical training and percutaneous transluminal coronary angioplasty in patients with recent myocardial infarction.,S Kanaya,Y Nishiyama,H Maeda,K Tokuda,M Tanaka,K Hirano,Y Koga,Japanese circulation journal,Vol. 64,No. 3,p. 165-9,2000年03月,研究論文(学術雑誌)
  • Cloning of a ribonuclease HII gene from a hyperthermophilic archaeon: Purification and characterization of a recombinant enzyme.,Haruki, M,Hayashi, K,Kouchi, T,Muroya, A,Koga, Y,Morikawa, M,Imanaka, T,Kanaya, S,J. Bacteriol.,1998年12月,研究論文(学術雑誌)
  • Thermostable glycerol kinase from a hyperthermophilic archaeon: gene cloning and characterization of the recombinant enzyme.,Y Koga,M Morikawa,M Haruki,H Nakamura,T Imanaka,S Kanaya,Protein engineering,OXFORD UNIV PRESS,Vol. 11,No. 12,p. 1219-27,1998年12月,研究論文(学術雑誌)
  • [Rare case of ulcerative colitis and ankylosing spondylitis associated with aortitis and severe aortic valve insufficiency].,S kanaya,K Tokuda,S Tanaka,K Hirano,Y Koga,T Imaizumi,S Suzuki,S Aoyagi,S Kato,A Koga,H Ajisaka,Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,Vol. 87,No. 11,p. 2316-8,1998年11月10日,研究論文(学術雑誌)
  • Aortic root replacement for Takayasu arteritis associated with ulcerative colitis and ankylosing spondylitis--report of a case.,S Aoyagi,H Akashi,T Kawara,K Ishihara,A Tanaka,S Kanaya,Y Koga,R Ishikawa,Japanese circulation journal,Vol. 62,No. 1,p. 64-8,1998年01月,研究論文(学術雑誌)

MISC

  • Crystal Structure of Glycoside Hydrolase Family 9 Endoglucanase with an N-Terminal Ig-Like Domain Isolated from Leaf-Branch Compost,Hiroyuki Okano,Eiko Kanaya,Masashi Ozaki,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,BIOPHYSICAL JOURNAL,CELL PRESS,Vol. 108,No. 2,p. 226A-226A,2015年01月,研究発表ペーパー・要旨(国際会議)
  • 超好熱菌由来プロテアーゼによるプリオン蛋白質分解の評価,清水 七海,古賀 雄一,作道 章一,原 英之,坂口 末廣,金谷 茂則,日本生化学会大会プログラム・講演要旨集,(公社)日本生化学会,Vol. 87回,p. [4P-149],2014年10月
  • 超好熱菌由来プロテアーゼによるプリオンタンパク質分解物の評価,古賀 雄一,清水 七海,作道 章一,原 英之,坂口 末廣,金谷 茂則,日本生物工学会大会講演要旨集,(公社)日本生物工学会,Vol. 平成26年度,p. 124-124,2014年08月
  • ナノバイオ応用に適した金/酸化鉄複合ナノ粒子の合成とその評価,清野智史,古賀雄一,土井健史,中川晋作,中川貴,山本孝夫,電気学会全国大会講演論文集(CD-ROM),Vol. 2014,2014年03月05日
  • プリオン病のサーベイランスと感染予防に関する調査研究 耐熱性プロテアーゼによる異常プリオン蛋白質の分解,古賀雄一,作道章一,平田あずみ,プリオン病のサーベイランスと感染予防に関する調査研究 平成25年度 総括・分担研究報告書,p. 88-89,2014年
  • プリオン病のサーベイランスと感染予防に関する調査研究 耐熱性プロテアーゼによるPrP<sup>Sc</sup>分解物の感染性の評価,古賀雄一,作道章一,平田あずみ,高野和文,プリオン病のサーベイランスと感染予防に関する調査研究 平成22-24年度 総合研究報告書,p. 61-63,2013年
  • プリオン病のサーベイランスと感染予防に関する調査研究 耐熱性プロテアーゼによるプリオン分解,古賀雄一,作道章一,高野和文,平田あずみ,プリオン病のサーベイランスと感染予防に関する調査研究 平成24年度 総括・分担研究報告書,p. 78-80,2013年
  • Rational Design of a Family I.3 Lipase Possessing Calcium-independent Activities,Maria Cheng,Clement Angkawidjaja,Yuichi Koga,Shigenori Kanaya,PROTEIN SCIENCE,WILEY-BLACKWELL,Vol. 21,p. 80-81,2012年08月,研究発表ペーパー・要旨(国際会議)
  • プリオン病のサーベイランスと感染予防に関する調査研究 耐熱性プロテアーゼによるプリオン分解,古賀雄一,作道章一,高野和文,平田あずみ,プリオン病のサーベイランスと感染予防に関する調査研究 平成23年度 総括・分担研究報告書,p. 73-75,2012年
  • Tk‐subtilisinによる異常型プリオンタンパク質分解効果の生物学的検討,平田あずみ,古賀雄一,田中俊一,作道章一,生田和良,金谷茂則,高野和文,日本生体防御学会学術総会講演抄録集,Vol. 23rd,2012年
  • 異常プリオン蛋白質(PrP<sup>Sc</sup>)の超好熱菌由来プロテアーゼによる分解,古賀雄一,田中俊一,作道章一,高野和文,金谷茂則,日本防菌防ばい学会年次大会要旨集,Vol. 38th,2011年08月30日
  • 金/酸化鉄磁性複合ナノ粒子を用いたタンパク質の精製,清野智史,澤祐司,中川貴,古賀雄一,岡田欣晃,土井健史,中川晋作,山本孝夫,日本磁気学会学術講演概要集,Vol. 34th,2010年09月04日
  • 超好熱菌由来プロテアーゼによる異常プリオン蛋白質分解,古賀 雄一,田中 俊一,作道 章一,高野 和文,金谷 茂則,日本生物工学会大会講演要旨集,(公社)日本生物工学会,Vol. 平成22年度,p. 25-25,2010年09月
  • 金/酸化鉄複合ナノ粒子のタンパク質吸着性能の評価,清野智史,澤祐司,舛賀康祐,中川貴,古賀雄一,小林望,岡田欣晃,土井健史,山本孝夫,ナノ学会大会講演予稿集,Vol. 8th,2010年05月13日
  • タンパク質立体構造の安定性に関与する「部位とアミノ酸残基」の関係,風間洋隆,田所高志,古賀雄一,高野和文,金谷茂則,生化学,2010年
  • 高度好塩菌由来RNase HIの高塩環境適応機構に関する研究,横山光士,田所高志,金谷栄子,古賀雄一,高野和文,金谷茂則,生化学,2010年
  • 低温菌Shewanella oneidensis MR‐1由来CutA1の安定性解析,佐藤彩,田所高志,古賀雄一,高野和文,金谷茂則,生化学,2010年
  • Structural and functional characterization of glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1,Ryuta Hokao,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF BIOSCIENCE AND BIOENGINEERING,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 108,p. S111-S111,2009年11月,研究発表ペーパー・要旨(国際会議)
  • 大腸菌リボヌクレアーゼHI5重置換熱安定化変異体の立体構造および熱力学的解析,春木満,田中雅紀,茂木毅彦,田所高志,古賀雄一,高野和文,金谷茂則,化学系学協会東北大会プログラムおよび講演予稿集,Vol. 2009,2009年09月19日
  • Arg142とPhe197はシュワネラ種SIB1由来FKBP22のプロリルイソメラーゼ活性に重要である(Importance of Arg142 and Phe197 for Prolyl Isomerase Activity of FKBP22 from Shewanella sp. SIB1),ブディマン・チャヒヨ,田所 高志,アンカウィジャヤ・クレメン,古賀 雄一,高野 和文,金谷 茂則,日本生化学会大会プログラム・講演要旨集,(公社)日本生化学会,Vol. 82回,p. 2P-417,2009年09月
  • Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII,Muhammad S. Rohman,Yuichi Koga,Kazufumi Takano,Hyongi Chon,Robert J. Crouch,Shigenori Kanaya,FEBS JOURNAL,WILEY-BLACKWELL,Vol. 275,No. 19,p. 4836-4849,2008年10月
  • Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII.,Muhammad S Rohman,Yuichi Koga,Kazufumi Takano,Hyongi Chon,Robert J Crouch,Shigenori Kanaya,The FEBS journal,WILEY-BLACKWELL,Vol. 275,No. 19,p. 4836-49,2008年10月
  • Remarkable stabilization of a psychrotrophic RNase HI by a combination of thermostabilizing mutations identified by the suppressor mutation method.,Takashi Tadokoro,Kyoko Matsushita,Yumi Abe,Muhammad Saifur Rohman,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 47,No. 31,p. 8040-7,2008年08月05日
  • Remarkable stabilization of a psychrotrophic RNase HI by a combination of thermostabilizing mutations identified by the suppressor mutation method,Takashi Tadokoro,Kyoko Matsushita,Yumi Abe,Muhammad Saifur Rohman,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,BIOCHEMISTRY,AMER CHEMICAL SOC,Vol. 47,No. 31,p. 8040-8047,2008年08月
  • Crystal structure of highly thermostable glycerol kinase from a hyperthermophilic archaeon in a dimeric form,Yuichi Koga,Ryota Katsumi,Dong-Ju You,Hiroyoshi Matsumura,Kazufumi Takano,Shigenori Kanaya,FEBS JOURNAL,WILEY-BLACKWELL,Vol. 275,No. 10,p. 2632-2643,2008年05月
  • Crystal structure of highly thermostable glycerol kinase from a hyperthermophilic archaeon in a dimeric form.,Yuichi Koga,Ryota Katsumi,Dong-Ju You,Hiroyoshi Matsumura,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,WILEY-BLACKWELL,Vol. 275,No. 10,p. 2632-43,2008年05月
  • Hydrophobic effect on the stability and folding of a hyperthermophilic protein.,Hongju Dong,Atsushi Mukaiyama,Takashi Tadokoro,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of molecular biology,Vol. 378,No. 1,p. 264-72,2008年04月18日
  • Hydrophobic effect on the stability and folding of a hyperthermophilic protein,Hongju Dong,Atsushi Mukaiyama,Takashi Tadokoro,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 378,No. 1,p. 264-272,2008年04月
  • Osmolyte effect on the stability and folding of a hyperthermophilic protein,Atsushi Mukaiyama,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,WILEY-LISS,Vol. 71,No. 1,p. 110-118,2008年04月
  • Osmolyte effect on the stability and folding of a hyperthermophilic protein.,Atsushi Mukaiyama,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Proteins,Vol. 71,No. 1,p. 110-8,2008年04月
  • 「酵素の機能改変における結晶構造の役割」、タンパク質結晶の新展開、,シーエムシー出版,2008年
  • Requirement of left-handed glycine residue for high stability of the Tk-subtilisin propeptide as revealed by mutational and crystallographic analyses.,Marian A Pulido,Shun-ichi Tanaka,Chutima Sringiew,Dong-Ju You,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of molecular biology,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 374,No. 5,p. 1359-73,2007年12月14日
  • Requirement of left-handed glycine residue for high stability of the Tk-subtilisin propeptide as revealed by mutational and crystallographic analyses,Marian A. Pulido,Shun-ichi Tanaka,Chutima Sringiew,Dong-Ju You,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 374,No. 5,p. 1359-1373,2007年12月
  • Structural and thermodynamic analyses of Escherichia coli RNase HI variant with quintuple thermostabilizing mutations,Mitsuru Haruki,Masaki Tanaka,Takehiko Motegi,Takashi Tadokoro,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS JOURNAL,BLACKWELL PUBLISHING,Vol. 274,No. 22,p. 5815-5825,2007年11月
  • Structural and thermodynamic analyses of Escherichia coli RNase HI variant with quintuple thermostabilizing mutations.,Mitsuru Haruki,Masaki Tanaka,Takehiko Motegi,Takashi Tadokoro,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,BLACKWELL PUBLISHING,Vol. 274,No. 22,p. 5815-25,2007年11月
  • Crystal structure of type 1 ribonuclease H from hyperthermophilic archaeon Sulfolobus tokodaii: role of arginine 118 and C-terminal anchoring.,Dong-Ju You,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 46,No. 41,p. 11494-503,2007年10月16日
  • Protein thermostabilization requires a fine-tuned placement of surface-charged residues.,Dong-Ju You,Satoshi Fukuchi,Ken Nishikawa,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of biochemistry,OXFORD UNIV PRESS,Vol. 142,No. 4,p. 507-16,2007年10月
  • Protein thermostabilization requires a fine-tuned placement of surface-charged residues,Dong-Ju You,Satoshi Fukuchi,Ken Nishikawa,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF BIOCHEMISTRY,OXFORD UNIV PRESS,Vol. 142,No. 4,p. 507-516,2007年10月
  • Crystal structure of type 1 ribonuclease H from hyperthermophilic Archaeon Sulfolobus tokodaii: Role of arginine 118 and C-terminal anchoring,Dong-Ju You,Hyongi Chons,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,BIOCHEMISTRY,AMER CHEMICAL SOC,Vol. 46,No. 41,p. 11494-11503,2007年10月
  • Four new crystal structures of Tk-subtilisin in unautoprocessed, autoprocessed and mature forms: insight into structural changes during maturation.,Shun-Ichi Tanaka,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of molecular biology,Vol. 372,No. 4,p. 1055-1069,2007年09月28日
  • Four new crystal structures of Tk-subtilisin in unautoprocessed, autoprocessed and mature forms: Insight into structural changes during maturation,Shun-ichi Tanaka,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,Vol. 372,No. 4,p. 1055-1069,2007年09月
  • Conformational contagion in a protein: structural properties of a chameleon sequence.,Kazufumi Takano,Yoshiaki Katagiri,Atsushi Mukaiyama,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Shigenori Kanaya,Proteins,WILEY-LISS,Vol. 68,No. 3,p. 617-25,2007年08月15日
  • 低温菌由来シャペロンを利用した蛋白質の可溶化発現,西尾明夏,古賀雄一,田所高志,大谷直人,高野和文,金谷茂則,日本生物工学会大会講演要旨集,Vol. 59th,2007年08月02日
  • RNase HIIIの基質結合に関与するアミノ酸残基の同定,宮下聖子,田所高志,古賀雄一,高野和文,金谷茂則,日本生物工学会大会講演要旨集,Vol. 59th,2007年08月02日
  • Conformational contagion in a protein: Structural properties of a chameleon sequence,Kazufumi Takano,Yoshiaki Katagiri,Atsushi Mukaiyama,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Shigenori Kanaya,PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,WILEY-LISS,Vol. 68,No. 3,p. 617-625,2007年08月
  • Identification of the gene encoding a type 1 RNase H with an N-terminal double-stranded RNA binding domain from a psychrotrophic bacterium,Takashi Tadokoro,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS JOURNAL,WILEY-BLACKWELL,Vol. 274,No. 14,p. 3715-3727,2007年07月
  • Identification of the gene encoding a type 1 RNase H with an N-terminal double-stranded RNA binding domain from a psychrotrophic bacterium.,Takashi Tadokoro,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,Vol. 274,No. 14,p. 3715-3727,2007年07月
  • Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI.,Takashi Tadokoro,Dong-Ju You,Yumi Abe,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,AMER CHEMICAL SOC,Vol. 46,No. 25,p. 7460-8,2007年06月26日
  • Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI,Takashi Tadokoro,Dong-Ju You,Yumi Abe,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,BIOCHEMISTRY,AMER CHEMICAL SOC,Vol. 46,No. 25,p. 7460-7468,2007年06月
  • サプレッサー変異法による低温蛋白質の安定化,田所高志,松下恭子,古賀雄一,高野和文,金谷茂則,日本蛋白質科学会年会プログラム・要旨集,Vol. 7th,2007年05月07日
  • Crystal structure of unautoprocessed precursor of subtilisin from a hyperthermophilic archaeon: evidence for Ca2+-induced folding.,Shun-ichi Tanaka,Kenji Saito,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The Journal of biological chemistry,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 282,No. 11,p. 8246-55,2007年03月16日
  • Extracellular overproduction and preliminary crystallographic analysis of a family I.3 lipase.,Clement Angkawidjaja,Dong-Ju You,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Acta crystallographica. Section F, Structural biology and crystallization communications,INT UNION CRYSTALLOGRAPHY,Vol. 63,No. Pt 3,p. 187-9,2007年03月01日
  • Crystal structure of unautoprocessed precursor of subtilisin from a hyperthermophilic Archaeon - Evidence for Ca2+-induced folding,Shun-ichi Tanaka,Kenji Saito,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF BIOLOGICAL CHEMISTRY,AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,Vol. 282,No. 11,p. 8246-8255,2007年03月
  • Directed evolution of Tk-subtilisin from a hyperthermophilic archaeon: identification of a single amino acid substitution responsible for low-temperature adaptation.,M A Pulido,Y Koga,K Takano,S Kanaya,Protein engineering, design & selection : PEDS,OXFORD UNIV PRESS,Vol. 20,No. 3,p. 143-53,2007年03月
  • Directed evolution of Tk-subtilisin from a hyperthermophilic archaeon: identification of a single amino acid substitution responsible for low-temperature adaptation,M. A. Pulido,Y. Koga,K. Takano,S. Kanaya,PROTEIN ENGINEERING DESIGN & SELECTION,OXFORD UNIV PRESS,Vol. 20,No. 3,p. 143-153,2007年03月
  • Extracellular overproduction and preliminary crystallographic analysis of a family I.3 lipase,Clement Angkawidjaja,Dong-Ju You,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Acta Crystallographica Section F: Structural Biology and Crystallization Communications,Vol. 63,No. 3,p. 187-189,2007年02月13日
  • Crystallization and preliminary X-ray diffraction study of glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakaraensis,Ryota Katsumi,Yuichi Koga,Dong-Ju You,Hiroyoshi Matsumura,Kazufumi Takano,Shigenori Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 63,p. 126-129,2007年02月
  • Crystallization and preliminary X-ray diffraction study of glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakaraensis,Ryota Katsumi,Yuichi Koga,Dong-Ju You,Hiroyoshi Matsumura,Kazufumi Takano,Shigenori Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 63,p. 126-129,2007年02月
  • “Creation of novel enantioselective lipases by SIMPLEX”In vitro transcription and translatio protocols, 2nd edition, Methods in molecular biology,Humana Press,2007年
  • Crystal structure of amyloid beta fragment,K. Takano,Y. Takeda,D. -J. You,A. Mukaiyama,H. Matsumura,Y. Koga,S. Kanaya,NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2007,MEDIMOND S R L,p. 153-156,2007年
  • Extracellular overproduction and preliminary crystallographic analysis of family I.3 lipase,Acta Crysatallographica Section F,Vol. 63, 187-189,2007年
  • "Creation of novel enantioselective lipases by SIMPLEX" In vitro transcription and translatio protocols, 2nd edition, Methods in molecular biology,Humana Press,2007年
  • Crystal structure of amyloid beta fragment,K. Takano,Y. Takeda,D. -J. You,A. Mukaiyama,H. Matsumura,Y. Koga,S. Kanaya,NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2007,MEDIMOND S R L,p. 153-156,2007年
  • Extracellular overproduction and preliminary crystallographic analysis of family I.3 lipase,Acta Crysatallographica Section F,Vol. 63, 187-189,2007年
  • A hyperthermophilic protein acquires function at the cost of stability.,Atsushi Mukaiyama,Mitsuru Haruki,Motonori Ota,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Biochemistry,Vol. 45,No. 42,p. 12673-9,2006年10月24日
  • Application of femtosecond laser ablation for detaching grown protein crystals from glass capillary tube,Masafumi Kashii,Ryo Fujisawa,Hiroaki Adachi,Yusuke Mori,Takatomo Sasaki,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Hiroyoshi Matsumura,Tsuyoshi Inoue,Satoshi Murakami,Kazuomi Sugamoto,Hideki Yoshikawa,JOURNAL OF BIOSCIENCE AND BIOENGINEERING,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 102,No. 4,p. 372-374,2006年10月
  • A hyperthermophilic protein acquires function at the cost of stability,Atsushi Mukaiyama,Mitsuru Haruki,Motonori Ota,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,BIOCHEMISTRY,AMER CHEMICAL SOC,Vol. 45,No. 42,p. 12673-12679,2006年10月
  • Application of femtosecond laser ablation for detaching grown protein crystals from glass capillary tube.,Masafumi Kashii,Ryo Fujisawa,Hiroaki Adachi,Yusuke Mori,Takatomo Sasaki,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Hiroyoshi Matsumura,Tsuyoshi Inoue,Satoshi Murakami,Kazuomi Sugamoto,Hideki Yoshikawa,Journal of bioscience and bioengineering,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 102,No. 4,p. 372-4,2006年10月
  • Crystallization and preliminary X-ray diffraction study of an active-site mutant of pro-Tk-subtilisin from a hyperthermophilic archaeon.,Shun-ichi Tanaka,Kenji Saito,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Acta crystallographica. Section F, Structural biology and crystallization communications,INT UNION CRYSTALLOGRAPHY,Vol. 62,No. Pt 9,p. 902-5,2006年09月01日
  • Crystallization and preliminary X-ray diffraction study of an active-site mutant of pro-Tk-subtilisin from a hyperthermophilic archaeon,Shun-ichi Tanaka,Kenji Saito,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 62,p. 902-905,2006年09月
  • 蛋白質の構造‐配列‐安定性相関に関する研究,松下恭子,田所高志,古賀雄一,高野和文,金谷茂則,日本生物工学会大会講演要旨集,Vol. 58th,2006年08月03日
  • Crystallization and preliminary crystallographic analysis of type 1 RNase H from the hyperthermophilic archaeon Sulfolobus tokodaii 7,Dong-Ju You,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 62,p. 781-784,2006年08月
  • Crystallization and preliminary crystallographic analysis of type 1 RNase H from the hyperthermophilic archaeon Sulfolobus tokodaii 7,Dong-Ju You,Hyongi Chon,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 62,p. 781-784,2006年08月
  • Effect of ultrasonic irradiation on protein crystallization,Keisuke Kakinouchi,Hiroaki Adachi,Hiroyoshi Matsumura,Tsuyoshi Inoue,Satoshi Murakami,Yusuke Mori,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF CRYSTAL GROWTH,ELSEVIER SCIENCE BV,Vol. 292,No. 2,p. 437-440,2006年07月
  • Extracellular secretion of Escherichia coli alkaline phosphatase with a C-terminal tag by type I secretion system: purification and biochemical characterization,C. Angkawidjaja,K. Kuwahara,K. Omori,Y. Koga,K. Takano,S. Kanaya,PROTEIN ENGINEERING DESIGN & SELECTION,OXFORD UNIV PRESS,Vol. 19,No. 7,p. 337-343,2006年07月
  • Effect of ultrasonic irradiation on protein crystallization,Keisuke Kakinouchi,Hiroaki Adachi,Hiroyoshi Matsumura,Tsuyoshi Inoue,Satoshi Murakami,Yusuke Mori,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,JOURNAL OF CRYSTAL GROWTH,ELSEVIER SCIENCE BV,Vol. 292,No. 2,p. 437-440,2006年07月
  • Extracellular secretion of Escherichia coli alkaline phosphatase with a C-terminal tag by type I secretion system: purification and biochemical characterization,C. Angkawidjaja,K. Kuwahara,K. Omori,Y. Koga,K. Takano,S. Kanaya,PROTEIN ENGINEERING DESIGN & SELECTION,OXFORD UNIV PRESS,Vol. 19,No. 7,p. 337-343,2006年07月
  • Ca2+-dependent maturation of subtilisin from a hyperthermophilic archaeon, Thermococcus kodakaraensis: the propeptide is a potent inhibitor of the mature domain but is not required for its folding.,Marian Pulido,Kenji Saito,Shun-Ichi Tanaka,Yuichi Koga,Masaaki Morikawa,Kazufumi Takano,Shigenori Kanaya,Applied and environmental microbiology,AMER SOC MICROBIOLOGY,Vol. 72,No. 6,p. 4154-62,2006年06月
  • Ca2+-dependent maturation of subtilisin from a hyperthermophilic archaeon, Thermococcus kodakaraensis: the propeptide is a potent inhibitor of the mature domain but is not required for its folding,M Pulido,K Saito,SI Tanaka,Y Koga,M Morikawa,K Takano,S Kanaya,APPLIED AND ENVIRONMENTAL MICROBIOLOGY,AMER SOC MICROBIOLOGY,Vol. 72,No. 6,p. 4154-4162,2006年06月
  • Identification of RNase HII from psychrotrophic bacterium, Shewanella sp SIB1 as a high-activity type RNase H,H Chon,T Tadokoro,N Ohtani,Y Koga,K Takano,S Kanaya,FEBS JOURNAL,BLACKWELL PUBLISHING,Vol. 273,No. 10,p. 2264-2275,2006年05月
  • Identification of RNase HII from psychrotrophic bacterium, Shewanella sp. SIB1 as a high-activity type RNase H.,Hyongi Chon,Takashi Tadokoro,Naoto Ohtani,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,The FEBS journal,BLACKWELL PUBLISHING,Vol. 273,No. 10,p. 2264-75,2006年05月
  • Amyloidogenecity and pitrilysin sensitivity of a lysine-free derivative of amyloid beta-peptide cleaved from a recombinant fusion protein.,Joel C Cornista,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of biotechnology,ELSEVIER SCIENCE BV,Vol. 122,No. 2,p. 186-97,2006年03月23日
  • Amyloidogenecity and pitrilysin sensitivity of a lysine-free derivative of amyloid beta-peptide cleaved from a recombinant fusion protein,JC Cornista,Y Koga,K Takano,S Kanaya,JOURNAL OF BIOTECHNOLOGY,ELSEVIER SCIENCE BV,Vol. 122,No. 2,p. 186-197,2006年03月
  • Crystal structure and structure-based mutational analyses of RNase HIII from Bacillus stearothermophilus: A new type 2 RNase H with TBP-like substrate-binding domain at the N terminus,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of Molecular Biology,Vol. 356,No. 1,p. 165-178,2006年02月10日
  • Crystal structure and structure-based mutational analyses of RNase HIII from Bacillus stearothermophilus: a new type 2 RNase H with TBP-like substrate-binding domain at the N terminus.,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Journal of molecular biology,Vol. 356,No. 1,p. 165-78,2006年02月10日
  • Structure of amyloid beta fragments in aqueous environments.,Kazufumi Takano,Shuji Endo,Atsushi Mukaiyama,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Shigenori Kanaya,The FEBS journal,BLACKWELL PUBLISHING,Vol. 273,No. 1,p. 150-8,2006年01月
  • 低温菌由来タンパク質の利用,実用産業情報,Vol. 39, 20-23,2006年
  • Structure of amyloid beta fragments in aqueous environments,K Takano,S Endo,A Mukaiyama,H Chon,H Matsumura,Y Koga,S Kanaya,FEBS JOURNAL,BLACKWELL PUBLISHING,Vol. 273,No. 1,p. 150-158,2006年01月
  • Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 Å resolution,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Proteins: Structure, Function and Genetics,Vol. 61,No. 3,p. 685-688,2005年11月15日
  • Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 A resolution.,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Proteins,Vol. 61,No. 3,p. 685-8,2005年11月15日
  • Binding analysis of a psychrotrophic FKBP22 to a folding intermediate of protein using surface plasmon resonance.,Yutaka Suzuki,Ohnmar Ye Win,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS letters,Vol. 579,No. 25,p. 5781-4,2005年10月24日
  • Importance of a repetitive nine-residue sequence motif for intracellular stability and functional structure of a family I.3 lipase.,Clement Angkawidjaja,Aditya Paul,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,FEBS letters,ELSEVIER SCIENCE BV,Vol. 579,No. 21,p. 4707-12,2005年08月29日
  • Novel strategy for protein exploration: High-throughput screening. assisted with fuzzy neural network,R Kato,H Nakano,H Konishi,K Kato,Y Koga,T Yamane,T Kobayashi,H Honda,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 351,No. 3,p. 683-692,2005年08月
  • Novel strategy for protein exploration: High-throughput screening. assisted with fuzzy neural network,R Kato,H Nakano,H Konishi,K Kato,Y Koga,T Yamane,T Kobayashi,H Honda,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 351,No. 3,p. 683-692,2005年08月
  • Mutational and crystallographic studies of RNase HIII from Bacillus stearothermophilus: importance of N-terminal domain on substrate binding,H Chon,K Takano,H Matsumura,Y Koga,S Kanaya,FEBS JOURNAL,WILEY-BLACKWELL PUBLISHING, INC,Vol. 272,p. 83-83,2005年07月,研究発表ペーパー・要旨(国際会議)
  • Protein crystal growth using laser-processed seed crystals,K Takeuchi,H Kitano,H Adachi,Y Mori,T Sasaki,H Matsumura,T Inoue,S Murakami,M Doi,Y Koga,K Takano,S Kanaya,JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS,JAPAN SOC APPLIED PHYSICS,Vol. 44,No. 5A,p. 3177-3179,2005年05月
  • Protein crystal growth using laser-processed seed crystals,K Takeuchi,H Kitano,H Adachi,Y Mori,T Sasaki,H Matsumura,T Inoue,S Murakami,M Doi,Y Koga,K Takano,S Kanaya,JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS,JAPAN SOC APPLIED PHYSICS,Vol. 44,No. 5A,p. 3177-3179,2005年05月
  • Crystallization and preliminary X-ray diffraction study of thermostable RNase HIII from Bacillus stearothermophilus,H Chon,H Matsumura,Y Koga,K Takano,S Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,BLACKWELL PUBLISHING,Vol. 61,p. 293-295,2005年03月
  • Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3,H Chon,H Matsumura,S Shimizu,N Maeda,Y Koga,K Takano,S Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 61,p. 319-322,2005年03月
  • Crystallization and preliminary X-ray diffraction study of thermostable RNase HIII from Bacillus stearothermophilus.,Hyongi Chon,Hiroyoshi Matsumura,Yuichi Koga,Kazufumi Takano,Shigenori Kanaya,Acta crystallographica. Section F, Structural biology and crystallization communications,Vol. 61,No. Pt 3,p. 293-5,2005年03月01日
  • Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3,H Chon,H Matsumura,S Shimizu,N Maeda,Y Koga,K Takano,S Kanaya,ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS,INT UNION CRYSTALLOGRAPHY,Vol. 61,p. 319-322,2005年03月
  • Binding analysis of a psychrotrophic FKBP22 to a folding intermediate of protein using surface plasmon resonance,FEBS Let.,Vol. 579, 5781-5784,2005年
  • Importance of a repetitive nine-residue sequence motif for intracellular stability and functional structure of a family I.3 lipase,FEBS Letters,Vol. 579, 21, 4707-4712,2005年
  • Inverting enantioselectivity of Burkholderia cepacia KWI-56 lipase by combinatorial mutation and high-throughput screening using single-molecule PCR and in vitro expression,Y Koga,K Kato,H Nakano,T Yamane,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 331,No. 3,p. 585-592,2003年08月
  • Inverting enantioselectivity of Burkholderia cepacia KWI-56 lipase by combinatorial mutation and high-throughput screening using single-molecule PCR and in vitro expression,Y Koga,K Kato,H Nakano,T Yamane,JOURNAL OF MOLECULAR BIOLOGY,ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD,Vol. 331,No. 3,p. 585-592,2003年08月
  • コンビナトリアルバイオエンジニアリング(第20章 無細胞タンパク質合成系によるタンパク質工学),化学同人,Vol. 第20章 無細胞タンパク質合成系によるタンパク質工学,2003年
  • In vitro construction and screening of a Burkholderia cepacia lipase library using single-molecule PCR and cell-free protein synthesis,Y Koga,K Kobayashi,JH Yang,H Nakano,T Yamane,JOURNAL OF BIOSCIENCE AND BIOENGINEERING,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 94,No. 1,p. 84-86,2002年07月
  • In vitro construction and screening of a Burkholderia cepacia lipase library using single-molecule PCR and cell-free protein synthesis,Y Koga,K Kobayashi,JH Yang,H Nakano,T Yamane,JOURNAL OF BIOSCIENCE AND BIOENGINEERING,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 94,No. 1,p. 84-86,2002年07月
  • Modifying the chain-length selectivity of the lipase from Burkholderia cepacia KWI-56 through in vitro combinatorial mutagenesis in the substrate-binding site,J Yang,Y Koga,H Nakano,T Yamane,PROTEIN ENGINEERING,OXFORD UNIV PRESS,Vol. 15,No. 2,p. 147-152,2002年02月
  • Modifying the chain-length selectivity of the lipase from Burkholderia cepacia KWI-56 through in vitro combinatorial mutagenesis in the substrate-binding site,J Yang,Y Koga,H Nakano,T Yamane,PROTEIN ENGINEERING,OXFORD UNIV PRESS,Vol. 15,No. 2,p. 147-152,2002年02月
  • Active subtilisin-like protease from a hyperthermophilic archaeon in a form with a putative prosequence.,Y Kannan,Y Koga,Y Inoue,M Haruki,M Takagi,T Imanaka,M Morikawa,S Kanaya,Applied and environmental microbiology,AMER SOC MICROBIOLOGY,Vol. 67,No. 6,p. 2445-52,2001年06月
  • Stabilities of chimeras of hyperthermophilic and mesophilic glycerol kinases constructed by DNA shuffling,Y Koga,M Haruki,M Morikawa,S Kanaya,JOURNAL OF BIOSCIENCE AND BIOENGINEERING,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 91,No. 6,p. 551-556,2001年06月
  • Active subtilisin-like protease from a hyperthermophilic archaeon in a form with a putative prosequence,Y Kannan,Y Koga,Y Inoue,M Haruki,M Takagi,T Imanaka,M Morikawa,S Kanaya,APPLIED AND ENVIRONMENTAL MICROBIOLOGY,AMER SOC MICROBIOLOGY,Vol. 67,No. 6,p. 2445-2452,2001年06月
  • Subtilisin-like protease from a hyperthermophilic archaeon,Bio Thailand 2001,2001年
  • Stabilities of chimeras of hyperthermophilic and mesophilic glycerol kinases constructed by DNA shuffling.,Y Koga,M Haruki,M Morikawa,S Kanaya,Journal of bioscience and bioengineering,Society of Fermentation and Bioengineering,Vol. 91,No. 6,p. 551-6,2001年
  • Subtilisin-like protease from a hyperthermophilic archaeon,Bio Thailand 2001,2001年
  • Gene cloning and characterization of recombinant RNase HII from a hyperthermophilic archaeon.,M Haruki,K Hayashi,T Kochi,A Muroya,Y Koga,M Morikawa,T Imanaka,S Kanaya,Journal of bacteriology,AMER SOC MICROBIOLOGY,Vol. 180,No. 23,p. 6207-14,1998年12月
  • Thermostable glycerol kinase from a hyperthermophilic archaeon: gene cloning and characterization of the recombinant enzyme,Protein Eng. 11, 1219-1227,Vol. 11, 1219-1227,1998年
  • Gene cloning and characterization of recombinant ribonuclease HII from a hyperthermophilic archaeon,J. Bacteriol. 180, 6207-6214,Vol. 180, 6207-6214,1998年
  • Thermostable glycerol kinase from a hyperthermophilic archaeon: gene cloning and characterization of the recombinant enzyme,Protein Eng. 11, 1219-1227,Vol. 11, 1219-1227,1998年

著書

  • 学術書,“Hyperthermophilic subtilisin-like protease from Themococcus kodakarensis.” (分担執筆)“Biotechnology of Microbial Enzymes, production, biocatalysis and industrial applications”,Uehara R,Takano K,Kanaya S,Koga Y,Academic Press,ISBN:9784864875868,2017年07月
  • 「地方創生に関わる生物工学のとりくみ地域生物資源産業化事例集」,古賀雄一,櫻谷英治,大政健史,三恵社,2016年11月

作品

  • 酵素のキラル分子認識機構の熱力学的解析,2008年 ~
  • 金磁性ナノ粒子をコア技術とする医療・診断・分析ツールの実用化,2008年 ~
  • 酵素のキラル分子認識機構の熱力学的解析,2007年 ~
  • 金磁性ナノ粒子をコア技術とする医療・診断・分析ツールの実用化,2007年 ~
  • 金磁性ナノ粒子をコア技術とする医療・診断・分析ツールの実用化,2006年 ~
  • 海外先進教育研究推進プログラム,2004年 ~

委員歴

  • 学協会,日本生物工学会,電子情報編集委員,2007年 ~