EN

基本情報

研究

社会活動

その他の活動

伊藤 幸裕

Itoh Yukihiro

産業科学研究所,准教授

keyword 生物有機化学,ケミカルバイオロジー,創薬化学,有機化学

経歴

  • 2020年06月 ~ 継続中,大阪大学,産業科学研究所,准教授
  • 2020年06月 ~ 継続中,京都府立医科大学,客員講師
  • 2019年04月 ~ 2020年05月,京都府立医科大学,医学(系)研究科(研究院),准教授

研究内容・専門分野

  • ライフサイエンス,薬系化学、創薬科学

論文

  • Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders,Tetsuya Iida,Yukihiro Itoh,Yukari Takahashi,Yasunobu Yamashita,Takashi Kurohara,Yuka Miyake,Makoto Oba,Takayoshi Suzuki,ChemMedChem,Wiley,2021年02月16日,研究論文(学術雑誌)
  • N<sup>+</sup>-C-H…O Hydrogen Bonds in Protein-Ligand Complexes and their Application to Drug Design,Yukihiro Itoh,Takashi Kurohara,Takayoshi Suzuki,Journal of Synthetic Organic Chemistry, Japan,The Society of Synthetic Organic Chemistry, Japan,Vol. 78,No. 12,p. 1151-1162,2020年12月01日,研究論文(学術雑誌)
  • Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor,Yuka Miyake,Yukihiro Itoh,Yoshinori Suzuma,Hidehiko Kodama,Takashi Kurohara,Yasunobu Yamashita,Remy Narozny,Yutaro Hanatani,Shusaku Uchida,Takayoshi Suzuki,ACS CATALYSIS,AMER CHEMICAL SOC,Vol. 10,No. 10,p. 5383-5392,2020年05月,研究論文(学術雑誌)
  • Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl- l -methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols,Shusuke Ogihara,Toru Komatsu,Yukihiro Itoh,Yuka Miyake,Takayoshi Suzuki,Kouichi Yanagi,Yusuke Kimura,Tasuku Ueno,Kenjiro Hanaoka,Hirotatsu Kojima,Takayoshi Okabe,Tetsuo Nagano,Yasuteru Urano,Journal of the American Chemical Society,Vol. 142,No. 1,p. 21-26,2020年,研究論文(学術雑誌)
  • Drug discovery researches on modulators of lysine-modifying enzymes based on strategic chemistry approaches,Yukihiro Itoh,Chemical and Pharmaceutical Bulletin,Vol. 68,No. 1,p. 34-45,2020年
  • Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.,Yeong KY,Khaw KY,Takahashi Y,Itoh Y,Murugaiyah V,Suzuki T,Bioorganic chemistry,Vol. 94,p. 103403-103403,2020年01月,研究論文(学術雑誌)
  • N<sup>+</sup>-C-H···O Hydrogen bonds in protein-ligand complexes.,Itoh Y,Nakashima Y,Tsukamoto S,Kurohara T,Suzuki M,Sakae Y,Oda M,Okamoto Y,Suzuki T,Scientific reports,Vol. 9,No. 1,2019年12月01日,研究論文(学術雑誌)
  • Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD<sup>+</sup>-Binding Site.,Mellini P,Itoh Y,Elboray EE,Tsumoto H,Li Y,Suzuki M,Takahashi Y,Tojo T,Kurohara T,Miyake Y,Miura Y,Kitao Y,Kotoku M,Iida T,Suzuki T,Journal of medicinal chemistry,Vol. 62,No. 12,p. 5844-5862,2019年06月27日,研究論文(学術雑誌)
  • Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.,Jaikhan P,Buranrat B,Itoh Y,Chotitumnavee J,Kurohara T,Suzuki T,Bioorganic & medicinal chemistry letters,Vol. 29,No. 10,p. 1173-1176,2019年05月15日,研究論文(学術雑誌)
  • Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.,Miyake Y,Itoh Y,Hatanaka A,Suzuma Y,Suzuki M,Kodama H,Arai Y,Suzuki T,Bioorganic & medicinal chemistry,Vol. 27,No. 6,p. 1119-1129,2019年03月15日,研究論文(学術雑誌)
  • Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor.,Ota Y,Nakamura A,Elboray EE,Itoh Y,Suzuki T,Chemical & pharmaceutical bulletin,Vol. 67,No. 3,p. 192-195,2019年,研究論文(学術雑誌)
  • Chemical Protein Degradation Approach and its Application to Epigenetic Targets.,Itoh Y,Chemical record (New York, N.Y.),Vol. 18,No. 12,p. 1681-1700,2018年12月
  • Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors.,Itoh Y,Suzuki M,Bioorganic & medicinal chemistry letters,Vol. 28,No. 16,p. 2723-2727,2018年09月01日,研究論文(学術雑誌)
  • Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations.,Tsukamoto S,Sakae Y,Itoh Y,Suzuki T,Okamoto Y,The Journal of chemical physics,Vol. 148,No. 12,2018年03月28日,研究論文(学術雑誌)
  • Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors.,Ota Y,Miyamura S,Araki M,Itoh Y,Yasuda S,Masuda M,Taniguchi T,Sowa Y,Sakai T,Itami K,Yamaguchi J,Suzuki T,Bioorganic & medicinal chemistry,Vol. 26,No. 3,p. 775-785,2018年02月01日,研究論文(学術雑誌)
  • Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors.,Kakizawa T,Ota Y,Itoh Y,Suzuki T,Bioorganic & medicinal chemistry letters,Vol. 28,No. 2,p. 167-169,2018年01月15日,研究論文(学術雑誌)
  • Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures.,Ota Y,Kakizawa T,Itoh Y,Suzuki T,Molecules (Basel, Switzerland),Vol. 23,No. 5,2018年,研究論文(学術雑誌)
  • Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.,Okuhira K,Shoda T,Omura R,Ohoka N,Hattori T,Shibata N,Demizu Y,Sugihara R,Ichino A,Kawahara H,Itoh Y,Ishikawa M,Hashimoto Y,Kurihara M,Itoh S,Saito H,Naito M,Molecular pharmacology,Vol. 91,No. 3,p. 159-166,2017年03月,研究論文(学術雑誌)
  • Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors,Yukihiro Itoh,Keisuke Aihara,Paolo Mellini,Toshifumi Tojo,Yosuke Ota,Hiroki Tsumoto,Viswas Raja Solomon,Peng Zhan,Miki Suzuki,Daisuke Ogasawara,Akira Shigenaga,Tsubasa Inokuma,Hidehiko Nakagawa,Naoki Miyata,Tamio Mizukami,Akira Otaka,Takayoshi Suzuki,Peptide Science 2016,p. 165-166,2017年02月26日,研究論文(大学,研究機関等紀要)
  • "Drug" Discovery with the Help of Organic Chemistry.,Itoh Y,Suzuki T,Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,Vol. 137,No. 3,p. 283-292,2017年
  • Potent mechanism-based sirtuin-2-selective inhibition by an <i>in situ</i>-generated occupant of the substrate-binding site, "selectivity pocket" and NAD<sup>+</sup>-binding site.,Mellini P,Itoh Y,Tsumoto H,Li Y,Suzuki M,Tokuda N,Kakizawa T,Miura Y,Takeuchi J,Lahtela-Kakkonen M,Suzuki T,Chemical science,Vol. 8,No. 9,p. 6400-6408,2017年,研究論文(学術雑誌)
  • Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice.,Higuchi F,Uchida S,Yamagata H,Abe-Higuchi N,Hobara T,Hara K,Kobayashi A,Shintaku T,Itoh Y,Suzuki T,Watanabe Y,The Journal of neuroscience : the official journal of the Society for Neuroscience,Vol. 36,No. 27,p. 7253-7267,2016年07月06日,研究論文(学術雑誌)
  • Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.,Itoh Y,Aihara K,Mellini P,Tojo T,Ota Y,Tsumoto H,Solomon VR,Zhan P,Suzuki M,Ogasawara D,Shigenaga A,Inokuma T,Nakagawa H,Miyata N,Mizukami T,Otaka A,Suzuki T,Journal of medicinal chemistry,Vol. 59,No. 4,p. 1531-1544,2016年02月25日,研究論文(学術雑誌)
  • Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide.,Kakizawa T,Mizukami T,Itoh Y,Hasegawa M,Sasaki R,Suzuki T,Bioorganic & medicinal chemistry letters,Vol. 26,No. 4,p. 1193-1195,2016年02月15日,研究論文(学術雑誌)
  • Molecular technology for controlling epigenetics: Regulation of histone acetylation and methylation by small molecules,Yukihiro Itoh,Takayoshi Suzuki,Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry,Vol. 74,No. 5,p. 441-452,2016年
  • False HDAC Inhibition by Aurone Compound.,Itoh Y,Suzuki M,Matsui T,Ota Y,Hui Z,Tsubaki K,Suzuki T,Chemical & pharmaceutical bulletin,Vol. 64,No. 8,p. 1124-1128,2016年,研究論文(学術雑誌)
  • C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors.,Miyamura S,Araki M,Ota Y,Itoh Y,Yasuda S,Masuda M,Taniguchi T,Sowa Y,Sakai T,Suzuki T,Itami K,Yamaguchi J,Organic & biomolecular chemistry,Vol. 14,No. 36,p. 8576-8585,2016年,研究論文(学術雑誌)
  • Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen.,Ota Y,Itoh Y,Kaise A,Ohta K,Endo Y,Masuda M,Sowa Y,Sakai T,Suzuki T,Angewandte Chemie (International ed. in English),Vol. 55,No. 52,p. 16115-16118,2016年,研究論文(学術雑誌)
  • Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.,Zhan P,Itoh Y,Suzuki T,Liu X,Journal of medicinal chemistry,Vol. 58,No. 19,p. 7611-7633,2015年10月08日,研究論文(学術雑誌)
  • Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells.,Itoh Y,Sawada H,Suzuki M,Tojo T,Sasaki R,Hasegawa M,Mizukami T,Suzuki T,ACS medicinal chemistry letters,Vol. 6,No. 6,p. 665-670,2015年06月11日,研究論文(学術雑誌)
  • Histone H3 peptide based LSD1-selective inhibitors.,Kakizawa T,Ota Y,Itoh Y,Tsumoto H,Suzuki T,Bioorganic & medicinal chemistry letters,Vol. 25,No. 9,p. 1925-1928,2015年05月01日,研究論文(学術雑誌)
  • Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1,Mohammed Naseer Ahmed Khan,Hiroki Tsumoto,Yukihiro Itoh,Yosuke Ota,Miki Suzuki,Daisuke Ogasawara,Hidehiko Nakagawa,Tamio Mizukami,Naoki Miyata,Takayoshi Suzuki,MedChemComm,Vol. 6,No. 3,p. 407-412,2015年03月01日,研究論文(学術雑誌)
  • Recent advances in the structure-based rational design of TNKSIs.,Zhan P,Song Y,Itoh Y,Suzuki T,Liu X,Molecular bioSystems,Vol. 10,No. 11,p. 2783-2799,2014年11月01日
  • Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues.,Sekizawa H,Amaike K,Itoh Y,Suzuki T,Itami K,Yamaguchi J,ACS medicinal chemistry letters,Vol. 5,No. 5,p. 582-586,2014年05月08日,研究論文(学術雑誌)
  • Identification of novel SIRT2-selective inhibitors using a click chemistry approach.,Tatum PR,Sawada H,Ota Y,Itoh Y,Zhan P,Ieda N,Nakagawa H,Miyata N,Suzuki T,Bioorganic & medicinal chemistry letters,Vol. 24,No. 8,p. 1871-1874,2014年04月,研究論文(学術雑誌)
  • Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors.,Suzuki T,Muto N,Bando M,Itoh Y,Masaki A,Ri M,Ota Y,Nakagawa H,Iida S,Shirahige K,Miyata N,ChemMedChem,Vol. 9,No. 3,p. 657-664,2014年03月,研究論文(学術雑誌)
  • Target-guided synthesis: Medicinal chemistry strategy to allow target enzymes themselves to synthesize their own inhibitors,Yukihiro Itoh,Naoki Miyata,Takayoshi Suzuki,Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry,Vol. 72,No. 6,p. 702-716,2014年
  • Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates.,Itoh Y,Ogasawara D,Ota Y,Mizukami T,Suzuki T,Computational and structural biotechnology journal,Vol. 9,No. 14,2014年,研究論文(学術雑誌)
  • Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.,Suzuki T,Ozasa H,Itoh Y,Zhan P,Sawada H,Mino K,Walport L,Ohkubo R,Kawamura A,Yonezawa M,Tsukada Y,Tumber A,Nakagawa H,Hasegawa M,Sasaki R,Mizukami T,Schofield CJ,Miyata N,Journal of medicinal chemistry,Vol. 56,No. 18,p. 7222-7231,2013年09月26日,研究論文(学術雑誌)
  • Search for a novel SIRT1 activator: structural modification of SRT1720 and biological evaluation.,Matsuya Y,Kobayashi Y,Uchida S,Itoh Y,Sawada H,Suzuki T,Miyata N,Sugimoto K,Toyooka N,Bioorganic & medicinal chemistry letters,Vol. 23,No. 17,p. 4907-4910,2013年09月01日,研究論文(学術雑誌)
  • Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.,Ogasawara D,Itoh Y,Tsumoto H,Kakizawa T,Mino K,Fukuhara K,Nakagawa H,Hasegawa M,Sasaki R,Mizukami T,Miyata N,Suzuki T,Angewandte Chemie (International ed. in English),Vol. 52,No. 33,p. 8620-8624,2013年08月12日,研究論文(学術雑誌)
  • Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.,Suzuki T,Kasuya Y,Itoh Y,Ota Y,Zhan P,Asamitsu K,Nakagawa H,Okamoto T,Miyata N,PloS one,Vol. 8,No. 7,2013年07月23日,研究論文(学術雑誌)
  • Small-molecular modulators of cancer-associated epigenetic mechanisms.,Itoh Y,Suzuki T,Miyata N,Molecular bioSystems,Vol. 9,No. 5,p. 873-896,2013年05月
  • Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.,Suzuki T,Ota Y,Ri M,Bando M,Gotoh A,Itoh Y,Tsumoto H,Tatum PR,Mizukami T,Nakagawa H,Iida S,Ueda R,Shirahige K,Miyata N,Journal of medicinal chemistry,Vol. 55,No. 22,p. 9562-9575,2012年11月26日,研究論文(学術雑誌)
  • Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist.,Itoh Y,Ishikawa M,Kitaguchi R,Okuhira K,Naito M,Hashimoto Y,Bioorganic & medicinal chemistry letters,Vol. 22,No. 13,p. 4453-4457,2012年07月01日,研究論文(学術雑誌)
  • Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.,Suzuki T,Khan MN,Sawada H,Imai E,Itoh Y,Yamatsuta K,Tokuda N,Takeuchi J,Seko T,Nakagawa H,Miyata N,Journal of medicinal chemistry,Vol. 55,No. 12,p. 5760-5773,2012年06月28日,研究論文(学術雑誌)
  • Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.,Itoh Y,Kitaguchi R,Ishikawa M,Naito M,Hashimoto Y,Bioorganic & medicinal chemistry,Vol. 19,No. 22,p. 6768-6778,2011年11月15日,研究論文(国際会議プロシーディングス)
  • Development of target protein-selective degradation inducer for protein knockdown.,Itoh Y,Ishikawa M,Kitaguchi R,Sato S,Naito M,Hashimoto Y,Bioorganic & medicinal chemistry,Vol. 19,No. 10,p. 3229-3241,2011年05月15日,研究論文(学術雑誌)
  • Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.,Okuhira K,Ohoka N,Sai K,Nishimaki-Mogami T,Itoh Y,Ishikawa M,Hashimoto Y,Naito M,FEBS letters,Vol. 585,No. 8,p. 1147-1152,2011年04月,研究論文(学術雑誌)
  • Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.,Hamada S,Suzuki T,Mino K,Koseki K,Oehme F,Flamme I,Ozasa H,Itoh Y,Ogasawara D,Komaarashi H,Kato A,Tsumoto H,Nakagawa H,Hasegawa M,Sasaki R,Mizukami T,Miyata N,Journal of medicinal chemistry,Vol. 53,No. 15,p. 5629-5638,2010年08月12日,研究論文(学術雑誌)
  • Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.,Itoh Y,Ishikawa M,Naito M,Hashimoto Y,Journal of the American Chemical Society,Vol. 132,No. 16,p. 5820-5826,2010年04月,研究論文(学術雑誌)
  • Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.,Hamada S,Kim TD,Suzuki T,Itoh Y,Tsumoto H,Nakagawa H,Janknecht R,Miyata N,Bioorganic & medicinal chemistry letters,Vol. 19,No. 10,p. 2852-2855,2009年05月15日,研究論文(学術雑誌)
  • Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.,Suzuki T,Igari S,Hirasawa A,Hata M,Ishiguro M,Fujieda H,Itoh Y,Hirano T,Nakagawa H,Ogura M,Makishima M,Tsujimoto G,Miyata N,Journal of medicinal chemistry,Vol. 51,No. 23,p. 7640-7644,2008年12月11日,研究論文(学術雑誌)
  • Isoform-selective histone deacetylase inhibitors.,Itoh Y,Suzuki T,Miyata N,Current pharmaceutical design,Vol. 14,No. 6,p. 529-544,2008年02月
  • Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.,Itoh Y,Suzuki T,Kouketsu A,Suzuki N,Maeda S,Yoshida M,Nakagawa H,Miyata N,Journal of medicinal chemistry,Vol. 50,No. 22,p. 5425-5438,2007年11月01日,研究論文(学術雑誌)
  • Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.,Suzuki T,Hisakawa S,Itoh Y,Suzuki N,Takahashi K,Kawahata M,Yamaguchi K,Nakagawa H,Miyata N,Bioorganic & medicinal chemistry letters,Vol. 17,No. 15,p. 4208-4212,2007年08月01日,研究論文(学術雑誌)
  • Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.,Suzuki T,Hisakawa S,Itoh Y,Maruyama S,Kurotaki M,Nakagawa H,Miyata N,Bioorganic & medicinal chemistry letters,Vol. 17,No. 6,p. 1558-1561,2007年03月15日,研究論文(学術雑誌)
  • Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.,Suzuki T,Kouketsu A,Itoh Y,Hisakawa S,Maeda S,Yoshida M,Nakagawa H,Miyata N,Journal of medicinal chemistry,Vol. 49,No. 16,p. 4809-4812,2006年08月10日,研究論文(学術雑誌)

MISC

  • Challenges of young chemists to be global,Toru Komatsu,Yukihiro Itoh,Yakugaku Zasshi,Vol. 139,No. 2,p. 185-186,2019年
  • Chemical biology for pharmaceutical sciences (novel ideas for “drug” discovery),Youhei Sohma,Yukihiro Itoh,Yakugaku Zasshi,Vol. 137,No. 3,p. 281-282,2017年
  • Study of Ligand Binding Selectivity of Histone Deacetylases by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations,Shuichiro Tsukamoto,Yoshitake Sakae,Yukihiro Itoh,Takayoshi Suzuki,Yuko Okamoto,BIOPHYSICAL JOURNAL,CELL PRESS,Vol. 110,No. 3,p. 544A-545A,2016年02月,研究発表ペーパー・要旨(国際会議)
  • MEDI 150-Design and synthesis of histone deacetylase 6 selective inhibitors,Takayoshi Suzuki,Akiyasu Kouketsu,Yukihiro Itoh,Shinya Hisakawa,Satoko Maeda,Minoru Yoshida,Hidehiko Nakagawa,Naoki Miyata,ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,AMER CHEMICAL SOC,Vol. 232,2006年09月,研究発表ペーパー・要旨(国際会議)