EN

基本情報

研究

社会活動

その他の活動

岡本 徹

Okamoto Tooru

高等共創研究院,教授

研究内容・専門分野

  • ライフサイエンス,ウイルス学

論文

  • Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.,Junki Hirano,Sachiyo Yoshio,Yusuke Sakai,Li Songling,Tatsuya Suzuki,Yumi Itoh,He Zhang,David Virya Chen,Saori Haga,Hiroko Oomori,Takahiro Kodama,Yusuke Maeda,Yoshihiro Ono,Yu Takahashi,Daron M Standley,Masahiro Yamamoto,Kohji Moriishi,Kyoji Moriya,Tatsuya Kanto,Tetsuo Takehara,Kazuhiko Koike,Yoshiharu Matsuura,Toru Okamoto,Proceedings of the National Academy of Sciences of the United States of America,Vol. 118,No. 22,2021年06月01日,研究論文(学術雑誌)
  • Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2.,Michael J Roy,Amelia Vom,Toru Okamoto,Brian J Smith,Richard W Birkinshaw,Hong Yang,Houda Abdo,Christine A White,David Segal,David C S Huang,Jonathan B Baell,Peter M Colman,Peter E Czabotar,Guillaume Lessene,Journal of medicinal chemistry,Vol. 64,No. 9,p. 5447-5469,2021年05月13日,研究論文(学術雑誌)
  • Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct-acting antivirals.,Satoru Joshita,Yuki Yamashita,Toru Okamoto,Yoko Usami,Ayumi Sugiura,Tomoo Yamazaki,Akemi Kakino,Masao Ota,Tatsuya Sawamura,Takeji Umemura,Hepatology research : the official journal of the Japan Society of Hepatology,2021年05月13日,研究論文(学術雑誌)
  • Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1.,Aya Nakae,Michiko Kodama,Toru Okamoto,Makoto Tokunaga,Hiroko Shimura,Kae Hashimoto,Kenjiro Sawada,Takahiro Kodama,Neal G Copeland,Nancy A Jenkins,Tadashi Kimura,Biochemical and biophysical research communications,Vol. 552,p. 120-127,2021年05月07日,研究論文(学術雑誌)
  • Deneddylation by SENP8 restricts hepatitis B virus propagation,David Virya Chen,Tatsuya Suzuki,Yumi Itoh,Yusuke Maeda,Junki Hirano,Saori Haga,He Zhang,Daiki Ito,Yoshiharu Matsuura,Toru Okamoto,Microbiology and Immunology,Vol. 65,No. 3,p. 125-135,2021年03月,研究論文(学術雑誌)
  • Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation,Yuzy Fauzyah,Chikako Ono,Shiho Torii,Itsuki Anzai,Rigel Suzuki,Takuma Izumi,Yuhei Morioka,Yusuke Maeda,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matsuura,Antiviral Research,Vol. 186,2021年02月,研究論文(学術雑誌)
  • MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex,Tirta Mario Djajawi,Lei Liu,Jia nan Gong,Allan Shuai Huang,Ming jie Luo,Zhen Xu,Toru Okamoto,Melissa J. Call,David C.S. Huang,Mark F. van Delft,Cell Death and Differentiation,Vol. 27,No. 8,p. 2484-2499,2020年08月01日,研究論文(学術雑誌)
  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis,Kiyoharu Fukushima,Takashi Satoh,Fuminori Sugihara,Yuki Sato,Toru Okamoto,Yuichi Mitsui,Sachiyo Yoshio,Songling Li,Satoshi Nojima,Daisuke Motooka,Shota Nakamura,Hiroshi Kida,Daron M. Standley,Eiichi Morii,Tatsuya Kanto,Motoko Yanagita,Yoshiharu Matsuura,Takashi Nagasawa,Atsushi Kumanogoh,Shizuo Akira,Immunity,Vol. 52,No. 3,p. 542-556.e13,2020年03月17日,研究論文(学術雑誌)
  • Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein,Makoto Tokunaga,Yoichi Miyamoto,Tatsuya Suzuki,Mayumi Otani,Shinsuke Inuki,Tsuyoshi Esaki,Chioko Nagao,Kenji Mizuguchi,Hiroaki Ohno,Yoshihiro Yoneda,Toru Okamoto,Masahiro Oka,Yoshiharu Matsuura,Virology,Vol. 541,p. 41-51,2020年02月,研究論文(学術雑誌)
  • Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma,Yohei Mano,Sachiyo Yoshio,Hirotaka Shoji,Shimagaki Tomonari,Yoshihiko Aoki,Nobuyoshi Aoyanagi,Toru Okamoto,Yoshiharu Matsuura,Yosuke Osawa,Kiminori Kimura,Kyohei Yugawa,Huanlin Wang,Yoshinao Oda,Tomoharu Yoshizumi,Yoshihiko Maehara,Tatsuya Kanto,Journal of Gastroenterology,Vol. 54,No. 11,p. 1007-1018,2019年11月01日,研究論文(学術雑誌)
  • In vivo dynamics of reporter flaviviridae viruses,Tomokazu Tamura,Manabu Igarashi,Bazarragchaa Enkhbold,Tatsuya Suzuki,Masatoshi Okamatsu,Chikako Ono,Hiroyuki Mori,Takuma Izumi,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Yoshihiro Sakoda,Takasuke Fukuhara,Yoshiharu Matsuura,Journal of Virology,Vol. 93,No. 22,2019年11月01日,研究論文(学術雑誌)
  • CXCR4 regulates Plasmodium development in mouse and human hepatocytes,Hironori Bando,Ariel Pradipta,Shiroh Iwanaga,Toru Okamoto,Daisuke Okuzaki,Shun Tanaka,Joel Vega-Rodríguez,Youngae Lee,Ji Su Ma,Naoya Sakaguchi,Akira Soga,Shinya Fukumoto,Miwa Sasai,Yoshiharu Matsuura,Masao Yuda,Marcelo Jacobs-Lorena,Masahiro Yamamoto,Journal of Experimental Medicine,Vol. 216,No. 8,p. 1733-1748,2019年08月01日,研究論文(学術雑誌)
  • Peroxiredoxin 1, a novel HBX-interacting protein, interacts with exosome component 5 and negatively regulates hepatitis B virus (HBV) propagation through degradation of HBV RNA,Lin Deng,Xiang Gan,Masahiko Ito,Ming Chen,Hussein H. Aly,Chieko Matsui,Takayuki Abe,Koichi Watashi,Takaji Wakita,Tetsuro Suzuki,Toru Okamoto,Yoshiharu Matsuura,Masashi Mizokami,Ikuo Shoji,Hak Hotta,Journal of Virology,Vol. 93,No. 6,2019年03月01日,研究論文(学術雑誌)
  • USP15 participates in hepatitis C virus propagation through regulation of viral RNA translation and lipid droplet formation,Shinji Kusakabe,Tatsuya Suzuki,Yukari Sugiyama,Saori Haga,Kanako Horike,Makoto Tokunaga,Junki Hirano,He Zhang,David Virya Chen,Hanako Ishiga,Yasumasa Komoda,Chikako Ono,Takasuke Fukuhara,Masahiro Yamamoto,Masahito Ikawa,Takashi Satoh,Shizuo Akira,Tomohisa Tanaka,Kohji Moriishi,Moto Fukai,Akinobu Taketomi,Sachiyo Yoshio,Tatsuya Kanto,Tetsuro Suzuki,Toru Okamoto,Yoshiharu Matsuura,Journal of Virology,Vol. 93,No. 6,2019年03月01日,研究論文(学術雑誌)
  • Induction of selective autophagy in cells replicating hepatitis C virus genome,Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Asuka Sato,Yuzy Fauzyah,Masami Wada,Toru Okamoto,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,Journal of General Virology,Vol. 99,No. 12,p. 1643-1657,2018年12月,研究論文(学術雑誌)
  • Baculovirus as a tool for gene delivery and gene therapy,Chikako Ono,Toru Okamoto,Takayuki Abe,Yoshiharu Matsuura,Viruses,Vol. 10,No. 9,2018年09月19日
  • St6gal1 knockdown alters HBV life cycle in HepAD38 cells,Surya Agung Priyambada,Ryo Misaki,Toru Okamoto,Takao Ohashi,Keiji Ueda,Yoshiharu Matsuura,Kazuhito Fujiyama,Biochemical and Biophysical Research Communications,Vol. 503,No. 3,p. 1841-1847,2018年09月10日,研究論文(学術雑誌)
  • Infection with flaviviruses requires BCLX<inf>L</inf> for cell survival,Tatsuya Suzuki,Toru Okamoto,Hiroshi Katoh,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Yuka Miyata,Takasuke Fukuhara,Masahito Ikawa,Takashi Satoh,Sachiyo Yoshio,Ryosuke Suzuki,Masayuki Saijo,David C.S. Huang,Tatsuya Kanto,Shizuo Akira,Yoshiharu Matsuura,PLoS Pathogens,Vol. 14,No. 9,2018年09月,研究論文(学術雑誌)
  • Novel miRNA biomarkers for genotoxicity screening in mouse,Hiroyuki Oka,Koichi Masuno,Takeki Uehara,Toru Okamoto,Yoshiharu Matsuura,Toru Nakano,Shinpei Yamaguchi,Toxicology,Elsevier Ireland Ltd,Vol. 404-405,p. 68-75,2018年07月01日,研究論文(学術雑誌)
  • Evaluation of viral contamination in a baculovirus expression system,Chikako Ono,Junki Hirano,Toru Okamoto,Yoshiharu Matsuura,Microbiology and Immunology,Blackwell Publishing Asia,Vol. 62,No. 3,p. 200-204,2018年03月,研究論文(学術雑誌)
  • Characterization of recombinant Flaviviridae viruses possessing a small reporter Tag,Tomokazu Tamura,Takasuke Fukuhara,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Takeshi Kurosu,Yin Xiang Setoh,Michio Imamura,Norbert Tautz,Yoshihiro Sakoda,Alexander A. Khromykh,Kazuaki Chayama,Yoshiharu Matsuura,Journal of Virology,American Society for Microbiology,Vol. 92,No. 2,2018年01月01日,研究論文(学術雑誌)
  • Characterization of SPP inhibitors suppressing propagation of HCV and protozoa,Junki Hirano,Toru Okamoto,Yukari Sugiyama,Tatsuya Suzuki,Shinji Kusakabe,Makoto Tokunaga,Takasuke Fukuhara,Miwa Sasai,Takahiro Tougan,Yasue Matsunaga,Kazuo Yamashita,Yusuke Sakai,Masahiro Yamamoto,Toshihiro Horii,Daron M. Standley,Kohji Moriishi,Kyoji Moriya,Kazuhiko Koike,Yoshiharu Matsuura,Proceedings of the National Academy of Sciences of the United States of America,NATL ACAD SCIENCES,Vol. 114,No. 50,p. E10782-E10791,2017年12月12日,研究論文(学術雑誌)
  • Suppression of HBV replication by the expression of nickase-and nuclease dead-Cas9,Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masaya Sugiyama,Daisuke Motooka,Shota Nakamura,Masato Ikawa,Masashi Mizokami,Yoshihiko Maehara,Yoshiharu Matsuura,Scientific Reports,NATURE PUBLISHING GROUP,Vol. 7,No. 1,2017年12月01日,研究論文(学術雑誌)
  • Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.,Tagami S,Yanagida K,Kodama TS,Takami M,Mizuta N,Oyama H,Nishitomi K,Chiu YW,Okamoto T,Ikeuchi T,Sakaguchi G,Kudo T,Matsuura Y,Fukumori A,Takeda M,Ihara Y,Okochi M,Cell Reports,Vol. 21,No. 1,p. 259-273,2017年10月03日,研究論文(学術雑誌)
  • Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.,Tagami S,Yanagida K,Kodama TS,Takami M,Mizuta N,Oyama H,Nishitomi K,Chiu YW,Okamoto T,Ikeuchi T,Sakaguchi G,Kudo T,Matsuura Y,Fukumori A,Takeda M,Ihara Y,Okochi M,Cell Rep.,Vol. 21,No. 1,p. 259-273,2017年10月03日,研究論文(学術雑誌)
  • Importin-independent nuclear translocation of flavivirus core proteins,Makoto Tokunaga,Toru Okamoto,Yoichi Miyamoto,Takasuke Fukuhara,Yoshiharu Matsuura,2017年10月,研究論文(その他学術会議資料等)
  • A deubiquitinating enzyme USP15 participates in the propagation of HCV through the regulation of lipid metabolism,Shinji Kusakabe,Toru Okamoto,Yukari Sugiyama,Takasuke Fukuhara,Kazuhiko Koike,Yoshiharu Matsuura,2017年10月,研究論文(その他学術会議資料等)
  • Characterization of selective autophagy induced by HCV RNA replication,Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Asuka Sato,Yuzy Fauzyah,Shinya Yamada,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,2017年10月,研究論文(その他学術会議資料等)
  • BCLXL dependent survivals upon infection with Flaviviruses,Tatsuya Suzuki,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura,2017年10月,研究論文(その他学術会議資料等)
  • Engineering of small reporter-tagged Flaviviridae viruses applicable to antiviral screening and in vivo dynamics,Tomokazu Tamura,Takasuke Fukuhara,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Kazuaki Chayama,Yoshiharu Matsuura,2017年10月,研究論文(その他学術会議資料等)
  • Involvement of other miRNA on the propagation of HCV in miR-1-deficient cells,Chikako Ono,Takasuke Fukuhara,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Kazuaki Chayama,Kazuhiko Koike,Yoshiharu Matsuura,2017年10月,研究論文(その他学術会議資料等)
  • The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses,Michihiro Takahama,Mitsunori Fukuda,Norihiko Ohbayashi,Tatsuya Kozaki,Takuma Misawa,Toru Okamoto,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh,Cell Reports,CELL PRESS,Vol. 20,No. 12,p. 2944-2954,2017年09月19日,研究論文(学術雑誌)
  • Engineering of Small Reporter-Tagged Flaviviridae Viruses Applicable to Antiviral Screening and in vivo Dynamics,Tomokazu Tamura,Takasuke Fukuhara,Akatuski Saito,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Tatuso Shioda,Kazuaki Chayama,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • Viral secretory glycoproteins of Pestivirus and Flavivirus have similar roles with exchangeable apolipoproteins on the formation of infectious HCV particles,Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Asuka Sato,Shinya Yamada,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • Selective TLR ligands stimulated pathogenicity of JEV infection in vivo,Yuka Miyata,Tatsuya Suzuki,Toru Okamoto,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • Importin-independent nuclear translocation of flavivirus core proteins,Makoto Tokunaga,Toru Okamoto,Yoichi Miyamoto,Takasuke Fukuhara,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • A deubiquitinating enzyme USP15 participates in the propagation of HCV through the regulation of lipid metabolism,Shinji Kusakabe,Toru Okamoto,Yukari Sugiyama,Takasuke Fukuhara,Kazuhiko Koike,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • cterization of selective autophagy induced by infection with hepatitis C virus,Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Asuka Sato,Yuzy Fauzyah,Masami Wada,Toru Okamoto,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • BCLXL participates in pathogenicity of flavivirus infection,Tatsuya Suzuki,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • Characterization of recombinant Flaviviridae viruses possessing a small reporter-tag,Tomokazu Tamura,Takasuke Fukuhara,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Kazuaki Chayama,Yoshiharu Matsuura,2017年09月,研究論文(国際会議プロシーディングス)
  • Regulation of apoptosis during flavivirus infection,Toru Okamoto,Tatsuya Suzuki,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Yuka Miyata,Yoshiharu Matsuura,Viruses,MDPI AG,Vol. 9,No. 9,2017年09月,研究論文(学術雑誌)
  • Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus,Surya Agung Priyambada,Ryo Misaki,Toru Okamoto,Yuta Okamoto,Takao Ohashi,Keiji Ueda,Yoshiharu Matsuura,Kazuhito Fujiyama,Virus Research,ELSEVIER SCIENCE BV,Vol. 238,p. 101-109,2017年06月15日,研究論文(学術雑誌)
  • Roles of miR-574-5p and miR-504-3p on the propagation of HCV in miR-122-deficient cells,Chikako Ono,Takasuke Fukuhara,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Kazuhiko Koike,Yoshiharu Matsuura,2017年06月,研究論文(国際会議プロシーディングス)
  • Characterization of Flaviviridae viruses possessing a reporter gene,Tomokazu Tamura,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Yoshiharu Matsuura,2017年06月,研究論文(国際会議プロシーディングス)
  • Characterization of selective autophagy induced by HCV RNA replication,Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Kentaro Uemura,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,2017年06月,研究論文(国際会議プロシーディングス)
  • BCLXL dependent survivals upon infection with Flaviviruses,Tatsuya Suzuki,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matsuura,2017年06月,研究論文(国際会議プロシーディングス)
  • Host-derived apolipoproteins play comparable roles with viral secretory proteins E-rns and NS1 in the infectious particle formation of Flaviviridae,Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Mai Shiokawa,Hiroyuki Mori,Kentaro Uemura,Satomi Yamamoto,Takeshi Kurihara,Toru Okamoto,Ryosuke Suzuki,Kentaro Yoshii,Takeshi Kurosu,Manabu Igarashi,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,PLOS PATHOGENS,PUBLIC LIBRARY SCIENCE,Vol. 13,No. 6,2017年06月,研究論文(学術雑誌)
  • Characterization of miR-122-independent propagation of HCV,Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Daisuke Okuzaki,Satomi Yamamoto,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Kentaro Uemura,Yuzy Fauzyah,Takeshi Kurihara,Takahiro Suda,Akira Nishio,Su Su Hmwe,Toru Okamoto,Tomohide Tatsumi,Tetsuo Takehara,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura,PLoS Pathogens,PUBLIC LIBRARY SCIENCE,Vol. 13,No. 5,2017年05月,研究論文(学術雑誌)
  • JMJD5 regulates HBV replication through interaction with HBx,Toru Okamoto,Kazuo Yamashita,Tatsuya Suzuki,Shinji Kusakabe,Junki Hirano,Takasuke Fukuhara,Atsuya Yamashita,Kazunobu Saito,Daisue Okuzaki,Daron M Stanley,Khoji Moriishi,Yoshiharu Matsuura,2017年04月,研究論文(国際会議プロシーディングス)
  • Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity,Takasuke Fukuhara,Satomi Yamamoto,Chikako Ono,Shota Nakamura,Daisuke Motooka,Hiroyuki Mori,Takeshi Kurihara,Asuka Sato,Tomokazu Tamura,Takashi Motomura,Toru Okamoto,Michio Imamura,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Yoshihiko Maehara,Kazuaki Chayama,Yoshiharu Matsuura,Scientific Reports,NATURE PUBLISHING GROUP,Vol. 7,2017年03月22日,研究論文(学術雑誌)
  • C型肝炎ウイルスの増殖と病原性に関与する宿主因子,Yoshiharu Matsuura,Takasuke Fukuhara,Toru Okamoto,2017年03月,研究論文(その他学術会議資料等)
  • Extensive Ca<sup>2+</sup> leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca<sup>2+</sup> hypersensitivity,Akira Uehara,Takashi Murayama,Midori Yasukochi,Michael Fill,Minoru Horie,Toru Okamoto,Yoshiharu Matsuura,Kiyoko Uehara,Takahiro Fujimoto,Takashi Sakurai,Nagomi Kurebayashi,Journal of General Physiology,ROCKEFELLER UNIV PRESS,Vol. 149,No. 2,p. 199-218,2017年,研究論文(学術雑誌)
  • Host-derived apolipoproteins play comparable roles with viral secretory proteins E<sup>rns</sup>and NS1 in the infectious particle formation of Flaviviridae,Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Mai Shiokawa,Hiroyuki Mori,Kentaro Uemura,Satomi Yamamoto,Takeshi Kurihara,Toru Okamoto,Ryosuke Suzuki,Kentaro Yoshii,Takeshi Kurosu,Manabu Igarashi,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,PLoS Pathogens,Public Library of Science,Vol. 13,No. 6,2017年,研究論文(学術雑誌)
  • Signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus,Yoshiharu Matsuura,Toru Okamoto,2016年10月,研究論文(その他学術会議資料等)
  • CDK9 inhibitor FIT-039 suppresses HBV propagation,Kohji Moriishi,Tomohisa Tanaka,Kaori Okuyama-obashi,Wenjia Chen,Toru Okamoto,Keiji Ueda,Takamitsu Hosoya,Yoshiharu Matsuura,Akihide Ryo,Yasuhito Tanaka,Masatoshi Hagiwara,2016年10月,研究論文(その他学術会議資料等)
  • Non-canonical LC3 lipidation induced by hepatitis C virus inhibits autophagic flux,Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,2016年10月,研究論文(国際会議プロシーディングス)
  • Human cathelicidin can compensate the role of apolipoproteins in the formation of infectious HCV particles,Tomokazu Tamura,Francesc Puig-Basagoiti,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Yoshiharu Matsuura,2016年10月,研究論文(国際会議プロシーディングス)
  • G28A mutation is necessary for an efficient propagation of HCV in miR-122 deficient condition,Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Satomi Yamamoto,Hiroyuki Mori,Kentaro Uemura,Toru Okamoto,Su Su Hmwe,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura,2016年10月,研究論文(国際会議プロシーディングス)
  • フラビウイルス科ウイルスの粒子産生における分泌性糖タンパク質の役割,Tomokazu Tamura,Takasuke Fukuhara,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Evaluation of γ-secretase inhibitors for HCV therapy,Junki Hirano,Yukari Sugiyama,Tatsuya Suzuki,Shinji Kusakabe,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Host factors participate in innate immune response upon infection with hepatitis B virus,Kentaro Uemura,Chikako Ono,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura,2016年10月
  • Glycine 135 of JMJD5 is involved in the interaction with HBx,Shinji Kusakabe,Takahisa Kouwaki,Yukari Sugiyama,Tatsuya Suzuki,Junki Hirano,Takasuke Fukuhara,Masaya Sugiyama,Masashi Mizokami,Toru Okamoto,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Non-canonical LC3 lipidation induced by HCV inhibits autophagic flux,Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Regulation of Bcl-2 family proteins in cells infected with Flaviviruses,Tatsuya Suzuki,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matusuura,2016年10月,研究論文(その他学術会議資料等)
  • Double nicking by Cas9-Nickase with pair sgRNAs cleaves HBV genome,Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Tomokazu Tamura,Toru Okamoto,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • The roles of secretory glycoproteins in viral particle formation in family Flaviviridae,Tomokazu Tamura,Takasuke Fukuhara,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • G28A mutation facilitates an efficient propagation of HCV in miR-122-independent manner,Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Satomi Yamamoto,Hiroyuki Mori,Kentaro Uemura,Toru Okamoto,Su Su Hmwe,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Regulation of Bcl-2 family proteins in cells infected with Flaviviruses,Toru Okamoto,Tatsuya Suzuki,Shinji Kusakabe,Junki Hirano,Makoto Tokunaga,Takasuke Fukuhara,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Single peptide peptidase a target for anti-HCV drug,Toru Okamoto,Junki Hirano,Tatsuya Suzuki,Shinji Kusakabe,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Viral secretory glycoproteins of Flaviviridae virus have similar roles with apolipoproteins on the formation of infectious HCV particles,Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Kentaro Uemura,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,2016年10月,研究論文(その他学術会議資料等)
  • Analysis of the HBV life cycle in a HepG2 expressing human NTCP,Retno Rahayu,Eriko Ohsaki,Toru Okamoto,Koichi Watash,Keiji Ueda,2016年10月
  • Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation,Tomohisa Tanaka,Kaori Okuyama-Dobashi,Shuko Murakami,Wenjia Chen,Toru Okamoto,Keiji Ueda,Takamitsu Hosoya,Yoshiharu Matsuura,Akihide Ryo,Yasuhito Tanaka,Masatoshi Hagiwara,Kohji Moriishi,Antiviral Research,ELSEVIER SCIENCE BV,Vol. 133,p. 156-164,2016年09月01日,研究論文(学術雑誌)
  • CHARACTERIZATION OF MIR-122-INDEPENDENT PROPAGATION OF HCV,Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Hiroyuki Mori,Kentaro Uemura,Yukako Kawachi,Toru Okamoto,Su Su Hmwe,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura,2016年06月,研究論文(国際会議プロシーディングス)
  • REGULATION OF BCL-2 FAMILY PROTEINS IN CELLS INFECTED WITH VIRUSES OF THE FAMILY FLAVIVIRIDAE,Tatsuya Suzuki,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matsuura,2016年06月,研究論文(国際会議プロシーディングス)
  • HUMAN CATHELICIDIN CAN COMPENSATE THE ROLE OF APOLIPOPROTEINS IN THE FORMATION OF INFECTIOUS HCV PARTICLES,Tomokazu Tamura,Francesc Puig-Basagoiti,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Yoshiharu Matsuura,2016年06月,研究論文(国際会議プロシーディングス)
  • VLDLR HAS A REDUNDANT ROLE WITH SR-B1 AND LDLR IN THE ENTRY OF LIPIDASSOCIATED HCV,Takasuke Fukuhara,Satomi Yamamoto,Chikako Ono,Tomokazu Tamura,Hiroyuki Mori,Yukako Kawachi,Kentaro Uemura,Toru Okamoto,Yoshiharu Matsuura,2016年06月,研究論文(国際会議プロシーディングス)
  • TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis,Sayaka Aizawa,Toru Okamoto,Yukari Sugiyama,Takahisa Kouwaki,Ayano Ito,Tatsuya Suzuki,Chikako Ono,Takasuke Fukuhara,Masahiro Yamamoto,Masayasu Okochi,Nobuhiko Hiraga,Michio Imamura,Kazuaki Chayama,Ryosuke Suzuki,Ikuo Shoji,Kohji Moriishi,Kyoji Moriya,Kazuhiko Koike,Yoshiharu Matsuura,Nature Communications,NATURE PUBLISHING GROUP,Vol. 7,2016年05月04日,研究論文(学術雑誌)
  • Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus,Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Kentaro Uemura,Yukako Kawachi,Mai Shiokawa,Hiroyuki Mori,Masami Wada,Ryoichi Shima,Toru Okamoto,Nobuhiko Hiraga,Ryosuke Suzuki,Kazuaki Chayama,Takaji Wakita,Yoshiharu Matsuura,PLoS Pathogens,PUBLIC LIBRARY SCIENCE,Vol. 12,No. 5,2016年05月,研究論文(学術雑誌)
  • Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA,Masuda, K,Ripley, B,Nyati, K,Dubey, P,Zaman, M,Hanieh, H,Hoga, M,Yamashita, K,Standley, D,Mashima, T,Katahira, M,Okamoto, T,Matsuura, Y,Takeuchi, O,Kishimoto, T,The Journal of experimental medicine,Vol. 213,No. 4,p. 605-619,2016年04月04日
  • Arid5a regulates naïve CD4+ T-cell fate through selective stabilization of Stat3 mRNA,Masuda K,Ripley B,Nyati KK,Dubey PK,Zaman NN,Hanieh H,Higa M,Yamashita K,Standley DM,Mashima T,Katahira M,Okamoto T,Matsuura Y,Takeuchi O,Kishimoto T,J Exp Med,Vol. 213,No. 4,p. 605-619,2016年04月,研究論文(学術雑誌)
  • Production of hepatitis E virus-like particles presenting multiple foreign epitopes by co-infection of recombinant baculoviruses,Ryoichi Shima,Tian Cheng Li,Yutaka Sendai,Chikako Kataoka,Yoshio Mori,Takayuki Abe,Naokazu Takeda,Toru Okamoto,Yoshiharu Matsuura,Scientific Reports,NATURE PUBLISHING GROUP,Vol. 6,2016年02月24日,研究論文(学術雑誌)
  • Human cathelicidin compensates for the role of apolipoproteins in hepatitis C virus infectious particle formation,Francesc Puig-Basagoiti,Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Kentaro Uemura,Yukako Kawachi,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hideki Aizaki,Yoshiharu Matsuura,Journal of Virology,AMER SOC MICROBIOLOGY,Vol. 90,No. 19,p. 8464-8477,2016年,研究論文(学術雑誌)
  • Roles of lipoprotein receptors in the entry of hepatitis C virus,Takasuke Fukuhara,Satomi Yamamoto,Chikako Ono,Hiroyuki Mori,Francesc Puig-Basagoiti,Toru Okamoto,Yoshiharu Matsuura,2016年01月,研究論文(国際会議プロシーディングス)
  • Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B,Sachiyo Yoshio,Masaya Sugiyama,Hirotaka Shoji,Yohei Mano,Eiji Mita,Toru Okamoto,Yoshiharu Matsuura,Alato Okuno,Osamu Takikawa,Masashi Mizokami,Tatsuya Kanto,Hepatology,WILEY-BLACKWELL,Vol. 63,No. 1,p. 83-94,2016年01月01日,研究論文(学術雑誌)
  • Hepatocyte factor JMJD5 regulates hepatitis B virus replication through interaction with HBx,Takahisa Kouwaki,Toru Okamoto,Ayano Ito,Yukari Sugiyama,Kazuo Yamashita,Tatsuya Suzuki,Shinji Kusakabe,Junki Hirano,Takasuke Fukuhara,Atsuya Yamashita,Kazunobu Saito,Daisuke Okuzaki,Koichi Watashi,Masaya Sugiyama,Sachiyo Yoshio,Daron M. Standley,Tatsuya Kanto,Masashi Mizokami,Kohji Moriishi,Yoshiharu Matsuura,Journal of Virology,AMER SOC MICROBIOLOGY,Vol. 90,No. 7,p. 3530-3542,2016年,研究論文(学術雑誌)
  • Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide,Kaori Okuyama-Dobashi,Hirotake Kasai,Tomohisa Tanaka,Atsuya Yamashita,Jun Yasumoto,Wenjia Chen,Toru Okamoto,Shinya Maekawa,Koichi Watashi,Takaji Wakita,Akihide Ryo,Tetsuro Suzuki,Yoshiharu Matsuura,Nobuyuki Enomoto,Kohji Moriishi,Scientific Reports,NATURE PUBLISHING GROUP,Vol. 5,2015年11月23日,研究論文(学術雑誌)
  • Involvement of FKBP6 in hepatitis C virus replication,Hirotake Kasai,Kunihiro Kawakami,Hiromasa Yokoe,Kentaro Yoshimura,Masanori Matsuda,Jun Yasumoto,Shinya Maekawa,Atsuya Yamashita,Tomohisa Tanaka,Masanori Ikeda,Nobuyuki Kato,Toru Okamoto,Yoshiharu Matsuura,Naoya Sakamoto,Nobuyuki Enomoto,Sen Takeda,Hideki Fujii,Masayoshi Tsubuki,Masami Kusunoki,Kohji Moriishi,Scientific Reports,NATURE PUBLISHING GROUP,Vol. 5,2015年11月16日,研究論文(学術雑誌)
  • TRC8-dependent proteasome degradation of immature core protein participates in pathogenesis of HCV,Toru Okamoto,Yukari Sugiyama,Takahisa Kouwaki,Ayano Ito,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura,2015年11月,研究論文(その他学術会議資料等)
  • Human cathelicidin (hCAP18/LL37) can compensate the role of apolipoproteins in the formation of infectious HCV particles,Puig-Basagoiti Francesc,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takshi Kurihara,Toru Okamoto,Yoshiharu Matsuura,2015年11月
  • Apolipoproteins and viral secretory glycoproteins participate in the infectious particle formation of Flaviviridae,Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,2015年11月,研究論文(その他学術会議資料等)
  • Roles of lipoprotein receptors in the lifecycle of HCV,Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Takeshi Kurihara,Francesc Puig-Basagoiti,Toru Okamoto,Yoshiharu Matsuura,2015年11月,研究論文(その他学術会議資料等)
  • Suppression of hepatitis B virus replication by CRISPR/Cas9 system,Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Satomi Yamamoto,Takahisa Kohwaki,Toru Okamoto,Yoshiharu Matsuura,2015年11月
  • Characterization of miR-122-independent propagation of HCV,Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Hiroyuki Mori,Toru Okamoto,Su Su Hmwe,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura,2015年11月
  • フラビウイルス科に共通した小胞体膜結合因子を介した粒子産生機構の解析,福原 崇介,田村 友和,塩川 舞,小野 慎子,山本 聡美,森 寛行,栗原 健,岡本 徹,青木 博史,迫田 義博,松浦 善治,2015年11月,研究論文(その他学術会議資料等)
  • Host or virus derived secretory membrane binding proteins are involved in formation of infectious Flavivirus particles,Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Puig-Basagoiti Francesc,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura,2015年11月,研究論文(その他学術会議資料等)
  • Regulation of Bcl-2 family proteins in cells infected with Flaviviruses,Tatsuya Suzuki,Toru Okamoto,Hiroshi Katoh,Takasuke Fukuhara,Yoshiharu Matsuura,2015年11月
  • Characterization of miR-122-independent propagation of HCV,Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Hiroyuki Mori,Toru Okamoto,Su Su Hmwe,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura,2015年10月,研究論文(国際会議プロシーディングス)
  • TRC8-dependent proteasome degradation of immature core protein participates in pathogenesis of HCV,Toru Okamoto,Yukari Sugiyama,Takahisa Kouwaki,Ayano Ito,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura,2015年10月,研究論文(国際会議プロシーディングス)
  • Signal peptide peptidase regulates propagation and pathogenesis of Hepatitis C Virus,Toru Okamoto,Yukari Sugiyama,Ayano Ito,Takasuke Fukuhara,Yoshiharu Matusuura,2015年09月,研究論文(国際会議プロシーディングス)
  • HCV Infection Inhibits Autophagy through Lipidation of LC3,Takasuke Fukuhara,Masami Wada,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Toru Okamoto,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura,2015年07月,研究論文(国際会議プロシーディングス)
  • Roles of Lipoprotein Receptors in the Lifecycle of Hepatitis C Virus,Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Mai Shiokawa,Masami Wada,Toru Okamoto,Yoshiharu Matsuura,2015年07月,研究論文(国際会議プロシーディングス)
  • JMJD5 regulates HBV replication through the interaction with HBx.,Takahisa Kouwaki,Toru Okamoto,Ayano Ito,Takasuke Fukuhara,Masaya Sugiyama,Masashi Mizokami,Yoshiharu Matsuura,2015年07月,研究論文(国際会議プロシーディングス)
  • Processing of core protein by signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus,Toru Okamoto,Sayaka Aizawa,Yukari Sugiyama,Takahisa Kouwaki,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura,2015年07月,研究論文(国際会議プロシーディングス)
  • Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin,Koji Matsuhisa,Seiji Yamane,Toru Okamoto,Akihiro Watari,Masuo Kondoh,Yoshiharu Matsuura,Kiyohito Yagi,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 462,No. 1,p. 52-57,2015年06月,研究論文(学術雑誌)
  • Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin,Koji Matsuhisa,Seiji Yamane,Toru Okamoto,Akihiro Watari,Masuo Kondoh,Yoshiharu Matsuura,Kiyohito Yagi,Biochemical and Biophysical Research Communications,ACADEMIC PRESS INC ELSEVIER SCIENCE,Vol. 462,No. 1,p. 52-57,2015年05月28日,研究論文(学術雑誌)
  • ゲノム編集技術を用いたHCVコアタンパク質の機能解析,岡本徹,相澤清香,杉山由加理,幸脇貴久,伊藤彩乃,鈴木達也,福原崇介,森石恆司,小池和彦,松浦善治,2015年05月,研究論文(その他学術会議資料等)
  • Processing of core protein by signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus,Toru Okamoto,Sayaka Aizawa,Takahisa Kouwaki,Tatsuya Suzuki,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura,2015年04月,研究論文(国際会議プロシーディングス)
  • Host factors involved in the propagation and pathogenesis of hepatitis C Virus,Toru Okamoto,Yoshiharu Matsuura,Inflammation and Immunity in Cancer,p. 103-108,2015年01月01日,論文集(書籍)内論文
  • Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles,Takasuke Fukuhara,Masami Wada,Chikako Ono,Toru Okamoto,Yoshiharu Matsuura,Vol. 10,No. 12,2014年12月01日,研究論文(学術雑誌)
  • Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.,Fukuhara T,Wada M,Nakamura S,Ono C,Shiokawa M,Yamamoto S,Motomura T,Okamoto T,Okuzaki D,Yamamoto M,Saito I,Wakita T,Koike K,Matsuura Y,PLoS pathogens,Vol. 10,No. 12,2014年12月,研究論文(学術雑誌)
  • HBx結合タンパク質JMJD5の同定と機能解析,幸脇貴久,岡本徹,相澤清香,杉山由加理,福原崇介,杉山真也,溝上雅史,松浦善治,2014年11月,研究論文(その他学術会議資料等)
  • Processing of core protein by signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus,Sayaka Aizawa,Toru Okamoto,Takahisa Kouwaki,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura,2014年11月
  • Host factors involved in HBV propagation and pathogenesis,Toru Okamoto,Takahisa Kouwaki,Ayano Ito,Takasuke Fukuhara,Yoshiharu Matsuura,2014年11月,研究論文(その他学術会議資料等)
  • バキュロウイルスによる哺乳動物細胞での遺伝子発現は自然免疫応答によって抑制される,小野慎子,山本聡美,二宮彰紀,阿部隆之,福原崇介,岡本徹,松浦善治,2014年11月
  • 遺伝子組換え酵母由来B型肝炎ウイルス様粒子の細胞表面への結合に関与する宿主因子の解析,松田麻未,鈴木亮介,嵯峨涼平,藤本陽,渡士幸一,相崎英樹,森石恆司,岡本徹,松浦善治,黒田俊一,脇田隆字,2014年11月,研究論文(その他学術会議資料等)
  • トリプシン・EDTAによるNTCP依存HBV感染の増強,土橋香織,葛西宏威,田中智久,陳文家,渡士幸一,脇田隆字,山下篤哉,梁明秀,岡本徹,松浦善治,森石恆司,2014年11月,研究論文(その他学術会議資料等)
  • HCVのQuasispeciesは増殖性に関与する,福原崇介,山本聡美,小野慎子,和田真実,岡本徹,茶山一彰,松浦善治,2014年11月,研究論文(その他学術会議資料等)
  • C型肝炎ウイルスの病原性発現におけるシグナルペプチドペプチダーゼの役割,岡本徹,相澤清香,杉山由加理,幸脇貴久,福原崇介,森石恆司,小池和彦,松浦善治,2014年11月,研究論文(その他学術会議資料等)
  • アポリポ蛋白質の両親媒性αヘリックスはHCVの感染性粒子産生に寄与する,和田真実,福原崇介,中村昇太,小野慎子,山本聡美,塩川舞,岡本徹,小池和彦,松浦善治,2014年11月,研究論文(その他学術会議資料等)
  • C型肝炎ウイルスの感染におけるアポリポタンパク質受容体の役割,山本聡美,福原崇介,小野慎子,和田真実,塩川舞,岡本徹,松浦善治,2014年11月,研究論文(その他学術会議資料等)
  • Amphipathic α-helices of Exchangeable Apolipoproteins Paticipate in the Particle Formation of Hepatitis C Virus,Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Satomi Yamamoto,Mai Shiokawa,Toru Okamoto,Kazuhiko Koike,Yoshiharu Matsuura,2014年09月,研究論文(国際会議プロシーディングス)
  • Characterization of HCV propagation in miR-122 knockout cells,Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Masami Wada,Toru Okamoto,Daisuke Okuzaki,Yoshiharu Matsuura,2014年09月,研究論文(国際会議プロシーディングス)
  • Amphipathic α-helices of Exchangeable Apolipoproteins Paticipate in the Particle Formation of HCV,Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Satomi Yamamoto,Mai Shiokawa,Toru Okamoto,Kazuhiko Koike,Yoshiharu Matsuura,2014年09月,研究論文(国際会議プロシーディングス)
  • Processing of Core Protein by Signal Peptide Peptidase Participates in Propagation and Pathogenesis of Hepatitis C Virus,Toru Okamoto,Sayaka Aizawa,Takahisa Kouwaki,Tatsuya Suzuki,Francesc Puig-Basagoiti,Shinya Watanabe,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matsuura,2014年09月,研究論文(その他学術会議資料等)
  • Processing of Core Protein by Signal Peptide Peptidase Participates in Propagation and Pathogenesis of Hepatitis C Virus,Toru Okamoto,Sayaka Aizawa,Takahisa Kouwaki,Tatsuya Suzuki,Francesc Puig-Basagoiti,Shinya Watanabe,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matsuura,2014年09月,研究論文(国際会議プロシーディングス)
  • miR-122遺伝子欠損Huh7細胞株におけるC型肝炎ウイルス(HCV)の増殖,福原 崇介,小野 慎子,塩川 舞,山本 聡美,和田 真実,奥崎 大介,岡本 徹,松浦 善治,2014年08月,研究論文(その他学術会議資料等)
  • Exchageable apolipoproteins participate in the particle formation of hepatitis C virus,Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Satomi Yamamoto,Mai Shiokawa,Toru Okamoto,Yoshiharu Matsuura,2014年06月,研究論文(国際会議プロシーディングス)
  • Characterization of HCV Propagation in miR-122 Knockout Cells,Chikako Ono,Takasuke Fukuhara,Mai Shiokawa,Satomi Yamamoto,Masami Wada,Toru Okamoto,Daisuke Okuzaki,Yoshiharu Matsuura,2014年06月,研究論文(国際会議プロシーディングス)
  • Further insights into the effects of pre-organizing the BimBH3 Helix,Toru Okamoto,David Segal,Kerry Zobel,Anna Fedorova,Hong Yang,Wayne J. Fairbrother,David C.S. Huang,Brian J. Smith,Kurt Deshayes,Peter E. Czabotar,ACS Chemical Biology,Vol. 9,No. 3,p. 838-839,2014年02月18日
  • Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells,Chikako Ono,Akinori Ninomiya,Satomi Yamamoto,Takayuki Abe,Xiauyu Wen,Takasuke Fukuhara,Miwa Sasai,Masahiro Yamamoto,Tatsuya Saitoh,Takashi Satoh,Taro Kawai,Ken J. Ishii,Shizuo Akira,Toru Okamoto,Yoshiharu Matsuura,Journal of Virology,Vol. 88,No. 4,p. 2157-2167,2014年02月,研究論文(学術雑誌)
  • Hallmarks of hepatitis C virus in equine hepacivirus,Tomohisa Tanaka,Hirotake Kasai,Atsuya Yamashita,Kaori Okuyama-Dobashi,Jun Yasumoto,Shinya Maekawa,Nobuyuki Enomoto,Toru Okamoto,Yoshiharu Matsuura,Masami Morimatsu,Noboru Manabe,Kazuhiko Ochiai,Kazuto Yamashita,Kohji Moriishi,Journal of Virology,AMER SOC MICROBIOLOGY,Vol. 88,No. 22,p. 13352-13366,2014年,研究論文(学術雑誌)
  • Novel permissive cell lines for complete propagation of hepatitis C virus,Mai Shiokawa,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Toru Okamoto,Noriyuki Watanabe,Takaji Wakita,Yoshiharu Matsuura,Journal of Virology,AMER SOC MICROBIOLOGY,Vol. 88,No. 10,p. 5578-5594,2014年,研究論文(学術雑誌)
  • Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53,Gemma L. Kelly,Stephanie Grabow,Stefan P. Glaser,Leah Fitzsimmons,Brandon J. Aubrey,Toru Okamoto,Liz J. Valente,Mikara Robati,Lin Tai,W. Douglas Fairlie,Erinna F. Lee,Mikael S. Lindstrom,Klas G. Wiman,David C.S. Huang,Philippe Bouillet,Martin Rowe,Alan B. Rickinson,Marco J. Herold,Andreas Strasser,Genes and Development,COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT,Vol. 28,No. 1,p. 58-70,2014年01月01日,研究論文(学術雑誌)
  • Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis,Toru Okamoto,Leigh Coultas,Donald Metcalf,Mark F. Van Delft,Stefan P. Glaser,Megumi Takiguchi,Andreas Strasser,Philippe Bouillet,Jerry M. Adams,David C.S. Huang,Proceedings of the National Academy of Sciences of the United States of America,NATL ACAD SCIENCES,Vol. 111,No. 1,p. 261-266,2014年,研究論文(学術雑誌)
  • HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia,Gabriela Brumatti,Marika Salmanidis,Chung H. Kok,Rebecca A. Bilardi,Jarrod J. Sandow,Natasha Silke,Kylie Mason,Jolanda Visser,Anissa M. Jabbour,Stefan P. Glaser,Toru Okamoto,Philippe Bouillet,Richard J. D'Andrea,Paul G. Ekert,Oncotarget,Impact Journals LLC,Vol. 4,No. 11,p. 1933-1947,2013年11月,研究論文(学術雑誌)
  • Hoxb8 regulates expression of microRNAs to control cell death and differentiation,M. Salmanidis,G. Brumatti,N. Narayan,B. D. Green,J. A. Van Den Bergen,J. J. Sandow,A. G. Bert,N. Silke,R. Sladic,H. Puthalakath,L. Rohrbeck,T. Okamoto,P. Bouillet,M. J. Herold,G. J. Goodall,A. M. Jabbour,P. G. Ekert,Cell Death and Differentiation,Vol. 20,No. 10,p. 1370-1380,2013年10月,研究論文(学術雑誌)
  • The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism,James M. Murphy,Peter E. Czabotar,Joanne M. Hildebrand,Isabelle S. Lucet,Jian Guo Zhang,Silvia Alvarez-Diaz,Rowena Lewis,Najoua Lalaoui,Donald Metcalf,Andrew I. Webb,Samuel N. Young,Leila N. Varghese,Gillian M. Tannahill,Esme C. Hatchell,Ian J. Majewski,Toru Okamoto,Renwick C.J. Dobson,Douglas J. Hilton,Jeffrey J. Babon,Nicos A. Nicola,Andreas Strasser,John Silke,Warren S. Alexander,Immunity,Vol. 39,No. 3,p. 443-453,2013年09月19日,研究論文(学術雑誌)
  • Understanding the biological context of NS5A-host interactions in HCV infection: A network-based approach,Lokesh P. Tripathi,Hiroto Kambara,Yi An Chen,Yorihiro Nishimura,Kohji Moriishi,Toru Okamoto,Eiji Morita,Takayuki Abe,Yoshio Mori,Yoshiharu Matsuura,Kenji Mizuguchi,Journal of Proteome Research,Vol. 12,No. 6,p. 2537-2551,2013年06月07日,研究論文(学術雑誌)
  • Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity,Toru Okamoto,Kerry Zobel,Anna Fedorova,Clifford Quan,Hong Yang,Wayne J. Fairbrother,David C.S. Huang,Brian J. Smith,Kurt Deshayes,Peter E. Czabotar,ACS Chemical Biology,Vol. 8,No. 2,p. 297-302,2013年02月15日,研究論文(学術雑誌)
  • Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation,Hiroshi Katoh,Toru Okamoto,Takasuke Fukuhara,Hiroto Kambara,Eiji Morita,Yoshio Mori,Wataru Kamitani,Yoshiharu Matsuura,Journal of Virology,Vol. 87,No. 1,p. 489-502,2013年01月,研究論文(学術雑誌)
  • Ifit1 inhibits japanese encephalitis virus replication through binding to 5= capped 2'-o unmethylated RNA,Taishi Kimura,Hiroshi Katoh,Hisako Kayama,Hiroyuki Saiga,Megumi Okuyama,Toru Okamoto,Eiji Umemoto,Yoshiharu Matsuur,Masahiro Yamamoto,Kiyoshi Takeda,Journal of Virology,Vol. 87,No. 18,p. 9997-10003,2013年,研究論文(学術雑誌)
  • Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins,Toru Okamoto,Stephanie Campbell,Ninad Mehta,John Thibault,Peter M. Colman,Michele Barry,David C.S. Huang,Marc Kvansakul,Journal of Virology,Vol. 86,No. 21,p. 11501-11511,2012年11月,研究論文(学術雑誌)
  • Bcl-2 family member Bcl-G is not a proapoptotic protein,M. Giam,T. Okamoto,J. D. Mintern,A. Strasser,P. Bouillet,Cell Death and Disease,Vol. 3,No. 10,2012年10月,研究論文(学術雑誌)
  • A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.,Yamamoto M,Okuyama M,Ma JS,Kimura T,Kamiyama N,Saiga H,Ohshima J,Sasai M,Kayama H,Okamoto T,Huang DC,Soldati-Favre D,Horie K,Takeda J,Takeda K,Immunity,Vol. 37,No. 2,p. 302-313,2012年08月24日,研究論文(学術雑誌)
  • Arabidopsis β1,2-xylosyltransferase: Substrate specificity and participation in the plant-specific N-glycosylation pathway,Hiroyuki Kajiura,Toru Okamoto,Ryo Misaki,Yoshiharu Matsuura,Kazuhito Fujiyama,Journal of Bioscience and Bioengineering,SOC BIOSCIENCE BIOENGINEERING JAPAN,Vol. 113,No. 1,p. 48-54,2012年01月,研究論文(学術雑誌)
  • ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18,Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda,Journal of Experimental Medicine,Vol. 208,No. 7,p. 1533-1546,2011年07月04日,研究論文(学術雑誌)
  • Deerpox virus encodes an inhibitor of apoptosis that regulates bak and bax,Logan Banadyga,Sing Chi Lam,Toru Okamoto,Marc Kvansakul,David C. Huang,Michele Barry,Journal of Virology,Vol. 85,No. 5,p. 1922-1934,2011年03月,研究論文(学術雑誌)
  • Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation,Kiyoko Okamoto,Yoshio Mori,Yasumasa Komoda,Toru Okamoto,Masayasu Okochi,Masatoshi Takeda,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura,Journal of Virology,Vol. 82,No. 17,p. 8349-8361,2008年09月,研究論文(学術雑誌)
  • A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication,Toru Okamoto,Hiroko Omori,Yuuki Kaname,Takayuki Abe,Yorihiro Nishimura,Tetsuro Suzuki,Tatsuo Miyamura,Tamotsu Yoshimori,Kohji Moriishi,Yoshiharu Matsuura,Journal of Virology,Vol. 82,No. 7,p. 3480-3489,2008年04月,研究論文(学術雑誌)
  • Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication,Shuhei Taguwa,Toru Okamoto,Takayuki Abe,Yoshio Mori,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura,Journal of Virology,Vol. 82,No. 6,p. 2631-2641,2008年03月,研究論文(学術雑誌)
  • Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice,Takashi Kimura,Michio Imamura,Nobuhiko Hiraga,Tsuyoshi Hatakeyama,Daiki Miki,Chiemi Noguchi,Nami Mori,Masataka Tsuge,Shoichi Takahashi,Yoshifumi Fujimoto,Eiji Iwao,Hidenori Ochi,Hiromi Abe,Toshiro Maekawa,Keiko Arataki,Chise Tateno,Katsutoshi Yoshizato,Takaji Wakita,Toru Okamoto,Yoshiharu Matsuura,Kazuaki Chayama,Journal of General Virology,Vol. 89,No. 9,p. 2108-2113,2008年,研究論文(学術雑誌)
  • Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency,Masahiro Yamamoto,Satoshi Uematsu,Toru Okamoto,Yoshiharu Matsuura,Shintaro Sato,Himanshu Kumar,Takashi Satoh,Tatsuya Saitoh,Kiyoshi Takeda,Ken J. Ishii,Osamu Takeuchi,Taro Kawai,Shizuo Akira,Journal of Experimental Medicine,Vol. 204,No. 9,p. 2233-2239,2007年09月03日,研究論文(学術雑誌)
  • Oligomerization of hepatitis C virus core protein is crucial for interaction with the cytoplasmic domain of E1 envelope protein,Kousuke Nakai,Toru Okamoto,Tomomi Kimura-Someya,Koji Ishii,Chang Kweng Lim,Hideki Tani,Eiko Matsuo,Takayuki Abe,Yoshio Mori,Tetsuro Suzuki,Tatsuo Miyamura,Jack H. Nunberg,Kohji Moriishi,Yoshiharu Matsuura,Journal of Virology,Vol. 80,No. 22,p. 11265-11273,2006年11月,研究論文(学術雑誌)
  • Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90,Toru Okamoto,Yorihiro Nishimura,Tohru Ichimura,Kensuke Suzuki,Tatsuo Miyamura,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura,EMBO Journal,Vol. 25,No. 20,p. 5015-5025,2006年10月18日,研究論文(学術雑誌)
  • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling,Masahiro Yamamoto,Toru Okamoto,Kiyoshi Takeda,Shintaro Sato,Hideki Sanjo,Satoshi Uematsu,Tatsuya Saitoh,Naoki Yamamoto,Hiroaki Sakurai,Ken J. Ishii,Shoji Yamaoka,Taro Kawai,Yoshiharu Matsuura,Osamu Takeuchi,Shizuo Akira,Nature Immunology,Vol. 7,No. 9,p. 962-970,2006年09月,研究論文(学術雑誌)
  • Characterization of HCV-like particles produced in a human hepatoma cell line by a recombinant baculovirus,Eiko Matsuo,Hideki Tani,Chang Kweng Lim,Yasumasa Komoda,Toru Okamoto,Hironobu Miyamoto,Kohji Moriishi,Shintaro Yagi,Arvind H. Patel,Tatsuo Miyamura,Yoshiharu Matsuura,Biochemical and Biophysical Research Communications,Vol. 340,No. 1,p. 200-208,2006年02月03日,研究論文(学術雑誌)
  • Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication,Yoshimi Tsuda,Yoshio Mori,Takayuki Abe,Tetsuo Yamashita,Toru Okamoto,Tohru Ichimura,Kohji Moriishi,Yoshiharu Matsuura,Microbiology and Immunology,Center for Academic Publications Japan,Vol. 50,No. 3,p. 225-234,2006年,研究論文(学術雑誌)
  • Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B,Itsuki Hamamoto,Yorihiro Nishimura,Toru Okamoto,Hideki Aizaki,Minyi Liu,Yoshio Mori,Takayuki Abe,Tetsuro Suzuki,Michael M.C. Lai,Tatsuo Miyamura,Kohji Moriishi,Yoshiharu Matsuura,Journal of Virology,Vol. 79,No. 21,p. 13473-13482,2005年11月,研究論文(学術雑誌)
  • Effect of heparin addition on expansion of cord blood hematopoietic progenitor cells in three-dimensional coculture with stromal cells in nonwoven fabrics,Toru Okamoto,Mutsumi Takagi,Toshihiro Soma,Hiroyasu Ogawa,Manabu Kawakami,Masaaki Mukubo,Kazusuke Kubo,Reiko Sato,Kazunori Toma,Toshiomi Yoshida,Journal of Artificial Organs,Vol. 7,No. 4,p. 194-202,2004年12月,研究論文(学術雑誌)

MISC

  • Indoleamine-2, 3-dioxygenase as the intrinsic anti-HBV effector that leads to durable immune responses in patients with acute hepatitis B: A comparative analysis with the sequence in hepatic flare,Sachiyo Yoshio,Masaya Sugiyama,Hirotaka Shoji,Yohei Mano,Yoshihiko Aoki,Toru Okamoto,Yoshiharu Matsuura,Masashi Mizokami,Tatsuya Kanto,HEPATOLOGY,WILEY-BLACKWELL,Vol. 62,p. 1010A-1010A,2015年10月,研究発表ペーパー・要旨(国際会議)
  • CRISPR/CAS9法によるPresenilin1/Presenilin2ダブルノックアウト細胞の作製,柳田 寛太,田上 真次,児玉 高志,岡本 徹,松浦 善治,武田 雅俊,大河内 正康,Dementia Japan,(一社)日本認知症学会,Vol. 29,No. 3,p. 421-421,2015年09月
  • Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90 (vol 25, pg 5015, 2006),Toru Okamoto,Yorihiro Nishimura,Tohru Ichimura,Kensuke Suzuki,Tatsuo Miyamura,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura,EMBO JOURNAL,NATURE PUBLISHING GROUP,Vol. 25,No. 23,p. 5634-5634,2006年11月

講演・口頭発表等

  • ウイルスによる宿主への感染戦略,岡本徹,宮崎大学医学獣医学総合研究科 大学院特別セミナー,2021年01月
  • ウイルス感染における細胞死の制御,岡本徹、鈴木達也、伊東祐美、平野順紀,第 93 回日本生化学会大会,2020年09月
  • ウイルスによる宿主への感染戦略,岡本徹,公益財団法人 川崎市産業振興財団 第28回 Tonomachi cafe,2020年08月

学術貢献

  • 1S10e デスシステムが紡ぎ出す命の物語,第 93 回日本生化学会大会シンポジウム,2020年09月14日 ~