小沼 健

Takeshi Onuma

理学研究科 生物科学専攻,助教

keyword ハウス,3D形成,左右非対称形成,DNA interference,オタマジャクシ型の発生,発生生物学,脊索動物,オタマボヤ,遺伝子スクリーニング,ライブイメージング


  • ライフサイエンス,細胞生物学
  • ライフサイエンス,発生生物学


  • Mouth opening is mediated by separation of dorsal and ventral daughter cells of the lip precursor cells in the larvacean, Oikopleura dioica.,2020年08月15日,研究論文(学術雑誌)
  • A genome database for a Japanese population of the larvacean Oikopleura dioica.,Vol. 62,No. 6,p. 450-461,2020年08月,研究論文(学術雑誌)
  • Protein phosphatase 2A is essential to maintain meiotic arrest, and to prevent Ca2+ burst at spawning and eventual parthenogenesis in the larvacean Oikopleura dioica.,Vol. 460,No. 2,p. 155-163,2020年04月15日
  • A chordate species lacking Nodal utilizes calcium oscillation and Bmp for left-right patterning.,Vol. 117,No. 8,p. 4188-4198,2020年02月25日
  • ANISEED 2019: 4D exploration of genetic data for an extended range of tunicates.,Vol. 48,No. D1,2020年01月08日
  • Mother-to-embryo vitellogenin transport in a viviparous teleost Xenotoca eiseni.,Vol. 116,No. 44,p. 22359-22365,2019年10月29日
  • Wavy movements of epidermis monocilia drive the neurula rotation that determines left-right asymmetry in ascidian embryos.,Vol. 448,No. 2,p. 173-182,2019年04月15日
  • Modified whole-mount in situ hybridisation and immunohistochemistry protocols without removal of the vitelline membrane in the appendicularian Oikopleura dioica.,Vol. 227,No. 5,p. 367-374,2017年09月,研究論文(学術雑誌)
  • Patterning and morphogenesis of the intricate but stereotyped oikoplastic epidermis of the appendicularian, Oikopleura dioica.,Vol. 428,No. 1,p. 245-257,2017年08月01日,研究論文(学術雑誌)
  • Genome-wide survey of miRNAs and their evolutionary history in the ascidian, Halocynthia roretzi.,Vol. 18,No. 1,p. 314-314,2017年04月20日,研究論文(学術雑誌)
  • DNA interference-mediated screening of maternal factors in the chordate Oikopleura dioica.,Vol. 7,p. 44226-44226,2017年03月10日,研究論文(学術雑誌)
  • Internal and external morphology of adults of the appendicularian, Oikopleura dioica: an SEM study.,Vol. 367,No. 2,p. 213-227,2017年02月,研究論文(学術雑誌)
  • Redundant mechanisms are involved in suppression of default cell fates during embryonic mesenchyme and notochord induction in ascidians.,Vol. 416,No. 1,p. 162-172,2016年08月01日,研究論文(学術雑誌)
  • Maternal and zygotic transcriptomes in the appendicularian, Oikopleura dioica: novel protein-encoding genes, intra-species sequence variations, and trans-spliced RNA leader.,Vol. 225,No. 3,p. 149-59,2015年06月
  • DNA interference: DNA-induced gene silencing in the appendicularian Oikopleura dioica.,Vol. 282,No. 1807,p. 20150435-20150435,2015年05月22日
  • Long-distance cell migration during larval development in the appendicularian, Oikopleura dioica.,Vol. 395,No. 2,p. 299-306,2014年11月15日,研究論文(学術雑誌)
  • RNA interference in the appendicularian Oikopleura dioica reveals the function of the Brachyury gene.,Vol. 223,No. 4,p. 261-7,2013年07月
  • Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity.,Vol. 26,No. 7,p. 2941-50,2012年07月,研究論文(学術雑誌)
  • Regulation of temporal and spatial organization of newborn GnRH neurons by IGF signaling in zebrafish.,Vol. 31,No. 33,p. 11814-24,2011年08月17日,研究論文(学術雑誌)
  • Expression of GnRH genes is elevated in discrete brain loci of chum salmon before initiation of homing behavior and during spawning migration.,Vol. 168,No. 3,p. 356-68,2010年09月15日
  • Changes in gene expression for GH/PRL/SL family hormones in the pituitaries of homing chum salmon during ocean migration through upstream migration.,Vol. 166,No. 3,p. 537-48,2010年05月01日
  • Changes in the plasma levels of insulin-like growth factor-I from the onset of spawning migration through upstream migration in chum salmon.,Vol. 165,No. 2,p. 237-43,2010年01月15日
  • Elevation of the plasma level of insulin-like growth factor-I with reproductive maturation prior to initiation of spawning migration of chum salmon.,Vol. 1163,p. 497-500,2009年04月
  • Activity of the pituitary-gonadal axis is increased prior to the onset of spawning migration of chum salmon.,Vol. 212,No. Pt 1,p. 56-70,2009年01月
  • Change of morphology and cytoskeletal protein gene expression during dibutyryl cAMP-induced differentiation in C6 glioma cells.,Vol. 28,No. 4,p. 519-28,2008年06月
  • Stimulatory effects of insulin-like growth factor 1 on expression of gonadotropin subunit genes and release of follicle-stimulating hormone and luteinizing hormone in masu salmon pituitary cells early in gametogenesis.,Vol. 25,No. 1,p. 88-98,2008年01月
  • Expression of hormone genes and osmoregulation in homing chum salmon: A minireview,Vol. 152,No. 2-3,p. 304-309,2007年06月,研究論文(学術雑誌)
  • Reproductive stage-related effects of salmon GnRH and sex steroid hormones on expression of genes encoding fushi tarazu factor 1 homolog and estrogen receptor alpha in masu salmon pituitary cells in vitro.,Vol. 152,No. 1,p. 64-72,2007年05月15日
  • Effects of salmon GnRH and sex steroid hormones on expression of genes encoding growth hormone/prolactin/somatolactin family hormones and a pituitary-specific transcription factor in masu salmon pituitary cells in vitro.,Vol. 143,No. 2,p. 129-41,2005年09月01日
  • Elevation of gene expression for salmon gonadotropin-releasing hormone in discrete brain loci of prespawning chum salmon during upstream migration.,Vol. 63,No. 2,p. 126-45,2005年05月
  • Year-to-year differences in plasma levels of steroid hormones in pre-spawning chum salmon.,Vol. 133,No. 2,p. 199-215,2003年09月,研究論文(学術雑誌)
  • Changes in expression of genes encoding gonadotropin subunits and growth hormone/prolactin/somatolactin family hormones during final maturation and freshwater adaptation in prespawning chum salmon,Vol. 20,No. 1-2,p. 23-33,2003年02月,研究論文(学術雑誌)


  • 若手研究者最優秀賞 (The Jimmie Dodd Memorial Prize),小沼健,15th International Congress of Comparative Endocrinology,2005年05月
  • 第31回日本比較内分泌学会 最優秀発表賞 (共著者),古熊俊治,小沼健,浦野明央,安東宏徳,2006年11月
  • 日本動物学会論文賞 (共著者),Furukuma S,Onuma T,Swanson P,Luo Q,Koide N,Okada H,Urano A,Ando H,2009年06月
  • The Endocrine Society Outstanding Abstract Award,小沼健,米国内分泌学会,2010年06月
  • The 3rd Annual Meeting of Whole-Organism Science Society Joint meeting with The 12th Annual Meeting of Structural-Biological Whole Cell Project 優秀発表賞,Onuma TA,Kishi K,Omotezako T,Nishida H,2013年09月
  • 2020 日本動物学会奨励賞,小沼健,2020年09月