Changes in gene expression in healthcare workers during night shifts: implications for immune response and health risks.

Ryota Nukiwa, Sayaka Oda, Hisatake Matsumoto, Mohamad Al Kadi, Shuhei Murao, Tsunehiro Matsubara, Shunichiro Nakao, Daisuke Okuzaki, Hiroshi Ogura, Jun Oda

Journal of intensive care　Vol. 13　No. 1　p. 14-14　2025年3月11日　研究論文（学術雑誌）

Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements

Tsuyoshi Takashima, Chao Zeng, Eitaro Murakami, Naoko Fujiwara, Masaharu Kohara, Hideki Nagata, Zhaozu Feng, Ayako Sugai, Yasue Harada, Rika Ichijo, Daisuke Okuzaki, Satoshi Nojima, Takahiro Matsui, Yasushi Shintani, Gota Kawai, Michiaki Hamada, Tetsuro Hirose, Kazuhiko Nakatani, Eiichi Morii

JCI Insight　Vol. 10　No. 5　2025年3月10日　研究論文（学術雑誌）

Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism

Mayu Yagita-Sakamaki, Takayoshi Ito, Taiki Sakaguchi, Shuichi Shimma, Bo Li, Daisuke Okuzaki, Daisuke Motooka, Shota Nakamura, Koji Hase, Eiichiro Fukusaki, Akira Kikuchi, Takashi Nagasawa, Atsushi Kumanogoh, Kiyoshi Takeda, Hisako Kayama

International Immunology　Vol. 37　No. 4　p. 235-250　2025年3月6日　研究論文（学術雑誌）

Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology

Yuki Nakayama, Miwa Sasai, Ayumi Kuratani, Masaaki Okamoto, Daisuke Okuzaki, Kentaro Yamamoto, Chikako Ono, Masaya Yamaguchi, Shigetada Kawabata, Noriko Shinjyo, Yasutaka Okabe, Yoshiharu Matsuura, Manabu Ato, Masahiro Yamamoto

iScience　Vol. 28　No. 3　p. 111975-111975　2025年2月　研究論文（学術雑誌）

HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells

Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

Cancer Immunology, Immunotherapy　Vol. 74　No. 3　2025年2月1日　研究論文（学術雑誌）

A nonactivating ITGB3 mutation in the β3 cytoplasmic region causes macrothrombocytopenia with an impaired αIIbβ3/RhoA pathway

Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Daisuke Motooka, Daisuke Okuzaki, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

Blood Vessels, Thrombosis & Hemostasis　2025年2月　研究論文（学術雑誌）

NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs

Nobuhiro Kobayashi, Saori Suzuki, Yuki Sakamoto, Rigel Suzuki, Kento Mori, Yume Kosugi, Tomoya Saito, Yuan Ma, Lihan Liang, Takuma Izumi, Kisho Noda, Daisuke Okuzaki, Yumi Kanegae, Sanae Hayashi, Yasuhito Tanaka, Atsuya Yamashita, Kohji Moriishi, Yoshiharu Matsuura, Osamu Takeuchi, Tomokazu Tamura, Akinobu Taketomi, Takasuke Fukuhara

Journal of General Virology　Vol. 106　No. 3　2025年　研究論文（学術雑誌）

mRNA-miRNA integration analysis of T-cell exhaustion in sepsis from community-acquired pneumonia.

Sayaka Oda, Hisatake Matsumoto, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito, Shinya Onishi, Arisa Muratsu, Yumi Mitsuyama, Daisuke Okuzaki, Hiroshi Ogura, Susumu Tanaka, Jun Oda

Acute medicine & surgery　Vol. 12　No. 1　2025年　研究論文（学術雑誌）

Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity.

Koto Ukon, Satoshi Nojima, Daisuke Motooka, Tsuyoshi Takashima, Masaharu Kohara, Hiroki Kiyokawa, Kenji Kimura, Eriko Fukui, Shinichiro Tahara, Kansuke Kido, Takahiro Matsui, Yasushi Shintani, Daisuke Okuzaki, Eiichi Morii

Pathology, research and practice　Vol. 266　p. 155805-155805　2024年12月31日　研究論文（学術雑誌）

Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α

Daisuke Umeda, Akikazu Harada, Daisuke Motooka, Shinichiro Tahara, Masako Kurashige, Kansuke Kido, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui, Shinji Matsumoto, Yasushi Shintani, Daisuke Okuzaki, Akira Kikuchi, Satoshi Nojima, Eiichi Morii

Scientific Reports　Vol. 14　No. 1　2024年12月30日　研究論文（学術雑誌）

CAR-NK cells derived from cord blood originate mainly from CD56⁻CD7⁺CD34⁻HLA-DR⁻Lin⁻ NK progenitor cells

Tansri Wibowo, Yosuke Kogue, Shunya Ikeda, Moto Yaga, Mana Tachikawa, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Yasutaka Ueda, Hisashi Kato, Kentaro Fukushima, Jiro Fujita, Tomoaki Ueda, Shinsuke Kusakabe, Akihisa Hino, Michiko Ichii, Chihaya Imai, Daisuke Okuzaki, Atsushi Kumanogoh, Naoki Hosen

Molecular Therapy Methods and Clinical Development　Vol. 32　No. 4　2024年12月12日　研究論文（学術雑誌）

Correction to: A newly identified gene Ahed plays essential roles in murine haematopoiesis (Nature Communications, (2024), 15, 1, (5090), 10.1038/s41467-024-49252-7)

Ritsuko Nakai, Takafumi Yokota, Masahiro Tokunaga, Mikiro Takaishi, Tomomasa Yokomizo, Takao Sudo, Henyun Shi, Yoshiaki Yasumizu, Daisuke Okuzaki, Chikara Kokubu, Sachiyo Tanaka, Katsuyoshi Takaoka, Ayako Yamanishi, Junko Yoshida, Hitomi Watanabe, Gen Kondoh, Kyoji Horie, Naoki Hosen, Shigetoshi Sano, Junji Takeda

Nature Communications　Vol. 15　No. 1　2024年12月　研究論文（学術雑誌）

Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice

Kenichi Nagata, Shoko Hashimoto, Daisuke Joho, Ryo Fujioka, Yukio Matsuba, Misaki Sekiguchi, Naomi Mihira, Daisuke Motooka, Yu-Chen Liu, Daisuke Okuzaki, Masataka Kikuchi, Shigeo Murayama, Takaomi C. Saido, Hiroshi Kiyama, Hiroki Sasaguri

eneuro　Vol. 11　No. 12　p. ENEURO.0260-24.2024　2024年11月26日　研究論文（学術雑誌）

IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis.

Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto

Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 48　2024年11月26日　研究論文（学術雑誌）

Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity.

Ayumi Kuratani, Masaaki Okamoto, Kazuki Kishida, Daisuke Okuzaki, Miwa Sasai, Shimon Sakaguchi, Hisashi Arase, Masahiro Yamamoto

Science (New York, N.Y.)　Vol. 386　No. 6724　2024年11月22日　研究論文（学術雑誌）

Serinc5 Regulates Sequential Chondrocyte Differentiation by Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes.

Kenji Hata, Kanta Wakamori, Akane Hirakawa-Yamamura, Sachi Ichiyama-Kobayashi, Masaya Yamaguchi, Daisuke Okuzaki, Yoshifumi Takahata, Tomohiko Murakami, Narikazu Uzawa, Takashi Yamashiro, Riko Nishimura

Journal of cellular physiology　Vol. 240　No. 1　2024年11月20日　研究論文（学術雑誌）

Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring.

Sang-Eun Kim, Ryota Noda, Yu-Chen Liu, Yukari Nakajima, Shoichiro Kameoka, Daisuke Motooka, Seiya Mizuno, Satoru Takahashi, Kento Takaya, Takehiko Murase, Kazuya Ikematsu, Katsiaryna Tratsiakova, Takahiro Motoyama, Masahiro Nakashima, Kazuo Kishi, Paul Martin, Shigeto Seno, Daisuke Okuzaki, Ryoichi Mori

EMBO reports　2024年11月18日　研究論文（学術雑誌）

Toxoplasma GRA15 expression on dendritic cells inhibits B cell differentiation and antibody production.

Yuki Nakayama, Fumiaki Ihara, Daisuke Okuzaki, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto

Parasitology international　p. 102995-102995　2024年11月16日　研究論文（学術雑誌）

The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells.

Eri Oguro-Igashira, Mari Murakami, Ryota Mori, Ryuichi Kuwahara, Takako Kihara, Masaharu Kohara, Makoto Fujiwara, Daisuke Motooka, Daisuke Okuzaki, Mitsuru Arase, Hironobu Toyota, Siyun Peng, Takayuki Ogino, Yasuji Kitabatake, Eiichi Morii, Seiichi Hirota, Hiroki Ikeuchi, Eiji Umemoto, Atsushi Kumanogoh, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 121　No. 44　2024年10月29日　研究論文（学術雑誌）

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions.

Tatsuya Yamazaki, Kenta Iwasaki, Susumu Tomono, Masaki Imai, Yuko Miwa, Masato Shizuku, Satoshi Ashimine, Kohei Ishiyama, Masanori Inui, Daisuke Okuzaki, Manabu Okada, Takaaki Kobayashi, Sachiko Akashi-Takamura

iScience　Vol. 27　No. 9　p. 110649-110649　2024年9月20日　研究論文（学術雑誌）

Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients

Shuhei Sakakibara, Yu-Chen Liu, Masakazu Ishikawa, Ryuya Edahiro, Yuya Shirai, Soichiro Haruna, Marwa Ali El Hussien, Zichang Xu, Songling Li, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Fuminori Sugihara, Yoko Naito, Daisuke Motooka, Chao-Yuan Tsai, Chikako Ono, Yoshiharu Matsuura, James B Wing, Hisatake Matsumoto, Hiroshi Ogura, Masato Okada, Atsushi Kumanogoh, Yukinari Okada, Daron M Standley, Hitoshi Kikutani, Daisuke Okuzaki

Life Science Alliance　Vol. 7　No. 12　p. e202402774-e202402774　2024年9月17日　研究論文（学術雑誌）

Neoself-antigens are the primary target for autoreactive T cells in human lupus.

Shunsuke Mori, Masako Kohyama, Yoshiaki Yasumizu, Asa Tada, Kaito Tanzawa, Tatsuya Shishido, Kazuki Kishida, Hui Jin, Masayuki Nishide, Shoji Kawada, Daisuke Motooka, Daisuke Okuzaki, Ryota Naito, Wataru Nakai, Teru Kanda, Takayuki Murata, Chikashi Terao, Koichiro Ohmura, Noriko Arase, Tomohiro Kurosaki, Manabu Fujimoto, Tadahiro Suenaga, Atsushi Kumanogoh, Shimon Sakaguchi, Yoshihiro Ogawa, Hisashi Arase

Cell　Vol. 187　No. 21　2024年9月11日　研究論文（学術雑誌）

Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern.

Shinichiro Tahara, Satoshi Nojima, Tsuyoshi Takashima, Daisuke Okuzaki, Eiichi Morii

Pathology, research and practice　Vol. 262　p. 155562-155562　2024年8月24日　研究論文（学術雑誌）

Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomes.

Arisa Muratsu, Sayaka Oda, Shinya Onishi, Jumpei Yoshimura, Hisatake Matsumoto, Yuki Togami, Yumi Mitsuyama, Hiroshi Ito, Daisuke Okuzaki, Hiroshi Ogura, Jun Oda

Virology journal　Vol. 21　No. 1　p. 190-190　2024年8月19日　研究論文（学術雑誌）

Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19.

David G Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas N Søndergaard, Shuhei Sakakibara, Fuminori Sugihara, Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito, Shinya Onishi, Arisa Muratsu, Yumi Mitsuyama, Hiroshi Ogura, Jun Oda, Daisuke Okuzaki, Hisatake Matsumoto, James B Wing

Nature communications　Vol. 15　No. 1　p. 6811-6811　2024年8月9日　研究論文（学術雑誌）

CD98 heavy chain protein is overexpressed in non-small cell lung cancer and is a potential target for CAR T-cell therapy.

Moto Yaga, Kana Hasegawa, Shunya Ikeda, Miwa Matsubara, Takashi Hiroshima, Toru Kimura, Yuya Shirai, Wibowo Tansri, Hirofumi Uehara, Mana Tachikawa, Yuzuru Okairi, Masayuki Sone, Hiromi Mori, Yosuke Kogue, Hiroki Akamine, Daisuke Okuzaki, Kotaro Kawagishi, Satoshi Kawanaka, Hiroyuki Yamato, Yukiyasu Takeuchi, Eiji Okura, Ryu Kanzaki, Jiro Okami, Itsuko Nakamichi, Shigeru Nakane, Aki Kobayashi, Takashi Iwazawa, Toshiteru Tokunaga, Hideoki Yokouchi, Yukihiro Yano, Junji Uchida, Masahide Mori, Kiyoshi Komuta, Tetsuro Tachi, Hideki Kuroda, Noriyuki Kijima, Haruhiko Kishima, Michiko Ichii, Shinji Futami, Yujiro Naito, Takayuki Shiroyama, Kotaro Miyake, Shohei Koyama, Haruhiko Hirata, Yoshito Takeda, Soichiro Funaki, Yasushi Shintani, Atsushi Kumanogoh, Naoki Hosen

Scientific reports　Vol. 14　No. 1　p. 17917-17917　2024年8月2日　研究論文（学術雑誌）

Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.

Yoshimitsu Nakanishi, Mayuko Izumi, Hiroaki Matsushita, Yoshihisa Koyama, Diego Diez, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Maiko Naito, Yumiko Mizuno, Yuta Yamaguchi, Tomoki Mae, Yu Noda, Kamon Nakaya, Satoshi Nojima, Fuminori Sugihara, Daisuke Okuzaki, Masahito Ikawa, Shoichi Shimada, Sujin Kang, Atsushi Kumanogoh

Neuron　2024年7月9日　研究論文（学術雑誌）

血管・脂肪組織由来分泌因子Favineの血管保護作用機序解明と治療応用

小林 祥子, 福原 充子, 山口 祐希, 加藤 恒, 喜多 俊文, 奥崎 大介, 藤島 裕也, 西澤 恭子, 大月 道夫, 宮下 かずや, 吉田 卓也, 福原 淳範, 森井 英一, 内山 進, 下村 伊一郎

日本内分泌学会雑誌　Vol. 100　No. 1　p. 428-428　2024年5月

Periportal macrophages protect against commensal-driven liver inflammation

Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii

Nature　Vol. 629　No. 8013　p. 901-909　2024年4月24日　研究論文（学術雑誌）

Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells

Lidan Zhang, Hayato Saito, Tatsuyoshi Higashimoto, Takayuki Kaji, Ayasa Nakamura, Kanako Iwamori, Ryoko Nagano, Daisuke Motooka, Daisuke Okuzaki, Akiyoshi Uezumi, Shigeto Seno, So ichiro Fukada

Cell Reports　Vol. 43　No. 4　p. 114052-114052　2024年4月23日　研究論文（学術雑誌）

The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases.

Leah Rie Varner, Taro Chaya, Yamato Maeda, Ryotaro Tsutsumi, Shanshan Zhou, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa

iScience　Vol. 27　No. 4　p. 109380-109380　2024年4月19日　研究論文（学術雑誌）

JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.

Hibiki Sakai, Hiroyasu Kamuro, Nagisa Tokunoh, Takeshi Izawa, Shigeyuki Tamiya, Ayaha Yamamoto, Shota Tanaka, Daisuke Okuzaki, Chikako Ono, Yoshiharu Matsuura, Yoshiaki Okada, Yasuo Yoshioka, Yasushi Fujio, Masanori Obana

American journal of physiology. Renal physiology　Vol. 326　No. 6　p. F931-F941-F941　2024年4月18日　研究論文（学術雑誌）

Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.

Lidan Zhang, Hayato Saito, Tatsuyoshi Higashimoto, Takayuki Kaji, Ayasa Nakamura, Kanako Iwamori, Ryoko Nagano, Daisuke Motooka, Daisuke Okuzaki, Akiyoshi Uezumi, Shigeto Seno, So-Ichiro Fukada

Cell reports　Vol. 43　No. 4　p. 114052-114052　2024年4月3日　研究論文（学術雑誌）

Longitudinal whole blood transcriptome analysis of a septic shock patient with secondary hemophagocytic syndrome.

Rio Fujimoto, Sayaka Oda, Hisatake Matsumoto, Shunichiro Nakao, Kentaro Shimizu, Daisuke Okuzaki, Jun Oda

QJM : monthly journal of the Association of Physicians　2024年3月9日　研究論文（学術雑誌）

Non-small cell lung cancer-specific CAR T cells targeting CD98hc

Moto Yaga, Kana Hasegawa, Shunya Ikeda, Miwa Matsubara, Takashi Hiroshima, Toru Kimura, Tansri Wibowo, Daisuke Okuzaki, Haruhiko Kishima, Yasushi Shintani, Atsushi Kumanogoh, Naoki Hosen

CANCER SCIENCE　Vol. 115　p. 1756-1756　2024年3月

ARF6-AMAP1 pathway is linked to induction of immunosuppressive chemokine expression for favor immune evasion

Ari Hashimoto, Haruka Handa, Soichiro Hata, Daisuke Okuzaki, Yoshizuki Fumoto, Akio Tsutaho, Yoshihiro Nishikawa, Yuzo Kodama, Satoshi Hirano, Shigeru Hashimoto, Hisataka Sabe

CANCER SCIENCE　Vol. 115　p. 1921-1921　2024年3月

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

Cell Reports　2024年2月8日

Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment

Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, Shuichiro Higo, Nagako Sougawa, Maki Takeda, Takuji Kawamura, Ryohei Matsuura, Daisuke Okuzaki, Toshihiko Toyofuku, Yoshiki Sawa, Li Liu, Shigeru Miyagawa

iScience　Vol. 27　No. 2　p. 108992-108992　2024年2月　研究論文（学術雑誌）

Impact of <scp>ACSL4</scp> on the prognosis of hepatocellular carcinoma: Association with cancer‐associated fibroblasts and the tumour immune microenvironment

Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Takahiro Tomiyama, Shohei Yoshiya, Takeo Toshima, Yu‐Chen Liu, Takeshi Iwasaki, Daisuke Okuzaki, Koji Taniguchi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

Liver International　Vol. 44　No. 4　p. 1011-1023　2024年1月31日　研究論文（学術雑誌）

Non-classical CD45RBlo memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection.

David G. Priest, Takeshi Ebihara, Janyerkye Tulyeu, Jonas Søndergaard, Shuhei Sakakibara, Fuminori Sugihara, Shunichiro Nakao, Yuki Togami, Jumpei Yoshimura, Hiroshi Ito, Shinya Onishi, Arisa Muratsu, Yumi Mitsuyama, Hiroshi Ogura, Jun Oda, Daisuke Okuzaki, Hisatake Matsumoto, James B. Wing

Nature communications　Vol. 15　No. 1　p. 6811-6811　2024年1月25日　研究論文（学術雑誌）

Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation

K. Amano, D. Okuzaki, Y. Kitaoka, S. Kato, M. Fujiwara, S. Tanaka, S. Iida

Journal of Dental Research　2024年1月17日　研究論文（学術雑誌）

Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors

Ayana Suzuki, Satoshi Nojima, Shinichiro Tahara, Daisuke Motooka, Masaharu Kohara, Daisuke Okuzaki, Mitsuyoshi Hirokawa, Eiichi Morii

Journal of Pathology and Translational Medicine　Vol. 58　No. 1　p. 22-28　2024年1月15日　研究論文（学術雑誌）

Cancer-associated SNRPD3 mutation confers resistance to hypoxia, which is attenuated by DRP1 inhibition.

Shingo Satoh, Kotaro Miyake, Yuichi Adachi, Kentaro Masuhiro, Shinji Futami, Yujiro Naito, Takayuki Shiroyama, Shohei Koyama, Yuta Yamaguchi, Hachiro Konaka, Hyota Takamatsu, Daisuke Okuzaki, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh

Biochemical and biophysical research communications　Vol. 696　p. 149511-149511　2024年1月10日　研究論文（学術雑誌）

Gp130–HIF1α axis–induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling

Sujin Kang, Shinya Onishi, Zhenzhen Ling, Hitomi Inoue, Yingying Zhang, Hao Chang, Hui Zhao, Tong Wang, Daisuke Okuzaki, Hiroshi Matsuura, Hyota Takamatsu, Jun Oda, Tadamitsu Kishimoto

Proceedings of the National Academy of Sciences　Vol. 121　No. 2　2024年1月9日　研究論文（学術雑誌）

Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice

Tsutomu Endo, Kiyonori Kobayashi, Takafumi Matsumura, Chihiro Emori, Manabu Ozawa, Shimpei Kawamoto, Daisuke Okuzaki, Keisuke Shimada, Haruhiko Miyata, Kentaro Shimada, Mayo Kodani, Yu Ishikawa-Yamauchi, Daisuke Motooka, Eiji Hara, Masahito Ikawa

Communications Biology　Vol. 7　No. 1　p. 16-16　2024年1月4日　研究論文（学術雑誌）

Tff1-expressing Tregs in lung prevent exacerbation of Bleomycin-induced pulmonary fibrosis.

Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto

Frontiers in immunology　Vol. 15　p. 1440918-1440918　2024年　研究論文（学術雑誌）

Tofogliflozin attenuates renal lipid deposition and inflammation &lt;i&gt;via&lt;/i&gt; PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Endocrine Journal　2024年　研究論文（学術雑誌）

Full-Length Nanopore Sequencing of Circular Rna Landscape in Peripheral Blood Cells Following Sequential Bnt162b2 Mrna Vaccination

Yu-Chen Liu, Masakazu Ishikawa, Shuhei Sakakibara, Mohamad Al Kadi, D. Motooka, Yoko Naito, Shingo Ito, Yuko Imamura, Hisatake Matsumoto, Fuminori Sugihara, Haruhiko Hirata, Hiroshi Ogura, D. Okuzaki

2024年

T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis.

Yumi Mitsuyama, Hisatake Matsumoto, Yuki Togami, Sayaka Oda, Shinya Onishi, Jumpei Yoshimura, Arisa Murtatsu, Hiroshi Ito, Hiroshi Ogura, Daisuke Okuzaki, Jun Oda

Frontiers in immunology　Vol. 15　p. 1368446-1368446　2024年　研究論文（学術雑誌）

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases

Yoshiaki Yasumizu, Daiki Takeuchi, Reo Morimoto, Yusuke Takeshima, Tatsusada Okuno, Makoto Kinoshita, Takayoshi Morita, Yasuhiro Kato, Min Wang, Daisuke Motooka, Daisuke Okuzaki, Yamami Nakamura, Norihisa Mikami, Masaya Arai, Xuan Zhang, Atsushi Kumanogoh, Hideki Mochizuki, Naganari Ohkura, Shimon Sakaguchi

Cell Genomics　Vol. 4　No. 2　p. 100473-100473　2024年1月　研究論文（学術雑誌）

The UDP-glucose/P2Y14 receptor axis promotes eosinophil-dependent large intestinal inflammation

Li Liu, Takayoshi Ito, Bo Li, Haruka Tani, Daisuke Okuzaki, Daisuke Motooka, Hazuki Miyazaki, Takayuki Ogino, Shota Nakamura, Kiyoshi Takeda, Hisako Kayama

International Immunology　Vol. 36　No. 4　p. 155-166　2023年12月18日　研究論文（学術雑誌）

d-Alanine Affects the Circadian Clock to Regulate Glucose Metabolism in Kidney.

Shinsuke Sakai, Youichi Tanaka, Yusuke Tsukamoto, Shihoko Kimura-Ohba, Atsushi Hesaka, Kenji Hamase, Chin-Ling Hsieh, Eiryo Kawakami, Hiraku Ono, Kotaro Yokote, Mitsuaki Yoshino, Daisuke Okuzaki, Hiroyo Matsumura, Atsuko Fukushima, Masashi Mita, Maiko Nakane, Masao Doi, Yoshitaka Isaka, Tomonori Kimura

Kidney360　Vol. 5　No. 2　p. 237-251　2023年12月15日　研究論文（学術雑誌）

Classification of patients with COVID-19 by blood RNA endotype: a prospective cohort study.

Jumpei Yoshimura, Yuki Togami, Takeshi Ebihara, Hisatake Matsumoto, Yumi Mitsuyama, Fuminori Sugihara, Haruhiko Hirata, Daisuke Okuzaki, Hiroshi Ogura

Microbiology spectrum　Vol. 11　No. 6　2023年11月15日　研究論文（学術雑誌）

Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice.

Hiroshi Tsuneki, Masanori Sugiyama, Kiyofumi Sato, Hisakatsu Ito, Sanaka Nagai, Kanta Kon, Tsutomu Wada, Nao Kobayashi, Takuya Okada, Naoki Toyooka, Masashi Kawasaki, Toshihiro Ito, Ryota Otsubo, Daisuke Okuzaki, Teruhito Yasui, Toshiyasu Sasaoka

European journal of pharmacology　Vol. 961　p. 176190-176190　2023年11月11日　研究論文（学術雑誌）

Dengue virus infection induces selective expansion of Vγ4 and Vγ6TCR γδ T cells in the small intestine and a cytokine storm driving vascular leakage in mice.

Takeshi Kurosu, Daisuke Okuzaki, Yusuke Sakai, Mohamad Al Kadi, Supranee Phanthanawiboon, Yasusi Ami, Masayuki Shimojima, Tomoki Yoshikawa, Shuetsu Fukushi, Noriyo Nagata, Tadaki Suzuki, Daisuke Kamimura, Masaaki Murakami, Hideki Ebihara, Masayuki Saijo

PLoS neglected tropical diseases　Vol. 17　No. 11　2023年11月8日　研究論文（学術雑誌）

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

Eri Kawakami, Norikazu Saiki, Yosuke Yoneyama, Chiharu Moriya, Mari Maezawa, Shuntaro Kawamura, Akiko Kinebuchi, Tamaki Kono, Masaaki Funata, Ayaka Sakoda, Shigeru Kondo, Takeshi Ebihara, Hisatake Matsumoto, Yuki Togami, Hiroshi Ogura, Fuminori Sugihara, Daisuke Okuzaki, Takashi Kojima, Sayaka Deguchi, Sebastien Vallee, Susan McQuade, Rizwana Islam, Madhusudan Natarajan, Hirohito Ishigaki, Misako Nakayama, Cong Thanh Nguyen, Yoshinori Kitagawa, Yunheng Wu, Kensaku Mori, Takayuki Hishiki, Tomohiko Takasaki, Yasushi Itoh, Kazuo Takayama, Yasunori Nio, Takanori Takebe

Cell stem cell　Vol. 30　No. 10　p. 1315-1330　2023年10月5日　研究論文（学術雑誌）

Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base Synchondrosis

K. Amano, Y. Kitaoka, S. Kato, M. Fujiwara, D. Okuzaki, T. Aikawa, M. Kogo, S. Iida

Journal of Dental Research　Vol. 102　No. 11　p. 1241-1251　2023年10月　研究論文（学術雑誌）

Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon.

Mugen Taniguchi, Ryu Okumura, Takahisa Matsuzaki, Ayaka Nakatani, Kei Sakaki, Shota Okamoto, Airi Ishibashi, Haruka Tani, Momoka Horikiri, Naritaka Kobayashi, Hiroshi Y Yoshikawa, Daisuke Motooka, Daisuke Okuzaki, Shota Nakamura, Toshiyuki Kida, Akihiko Kameyama, Kiyoshi Takeda

Mucosal immunology　Vol. 16　No. 5　p. 624-641　2023年10月　研究論文（学術雑誌）

Opposing roles of RUBCN isoforms in autophagy and memory B cell generation.

Chao-Yuan Tsai, Shuhei Sakakibara, Yu-Diao Kuan, Hiroko Omori, Maruwa Ali El Hussien, Daisuke Okuzaki, Shiou-Ling Lu, Takeshi Noda, Keisuke Tabata, Shuhei Nakamura, Tamotsu Yoshimori, Hitoshi Kikutani

Science signaling　Vol. 16　No. 803　2023年9月19日　研究論文（学術雑誌）

Differential dependence on microbiota of IL-23/IL-22-dependent gene expression between the small- and large-intestinal epithelia.

Ayaka Nakatani, Ryu Okumura, Airi Ishibashi, Shota Okamoto, Kei Sakaki, Yuki Ito, Daisuke Okuzaki, Hidenori Inohara, Kiyoshi Takeda

Genes to cells : devoted to molecular & cellular mechanisms　2023年9月7日　研究論文（学術雑誌）

ARF6-AMAP1経路は免疫抑制性ケモカインの発現を誘導し、免疫回避に有利に機能する(ARF6-AMAP1 pathway is linked to induction of immunosuppressive chemokine expression for favor immune evasion)

橋本 あり, 半田 悠, 畑 宗一郎, 奥崎 大介, 麓 佳月, 蔦保 暁生, 西川 義浩, 児玉 裕三, 平野 聡, 橋本 茂, 佐邊 壽孝

日本癌学会総会記事　Vol. 82回　p. 1922-1922　2023年9月

Importance of microRNAs by mRNA-microRNA integration analysis in acute ischemic stroke patients.

Hideaki Kanki, Hisatake Matsumoto, Yuki Togami, Daisuke Okuzaki, Hiroshi Ogura, Tsutomu Sasaki, Hideki Mochizuki

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　Vol. 32　No. 9　p. 107277-107277　2023年9月　研究論文（学術雑誌）

Increased anti-oxidative action compensates for collagen tissue degeneration in vitiligo dermis.

Kazunori Yokoi, Yoshiaki Yasumizu, Naganari Ohkura, Koei Shinzawa, Daisuke Okuzaki, Nene Shimoda, Hideya Ando, Nanako Yamada, Manabu Fujimoto, Atsushi Tanemura

Pigment cell & melanoma research　Vol. 36　No. 5　p. 355-364　2023年9月　研究論文（学術雑誌）

Combination of HBA1, TTR, and SERPINF2 in plasma defines phenotype correlated with severe burn outcome

Shinya Onishi, Hisatake Matsumoto, Fuminori Sugihara, Takeshi Ebihara, Hiroshi Matsuura, Akinori Osuka, Daisuke Okuzaki, Hiroshi Ogura, Jun Oda

iScience　Vol. 26　No. 8　2023年8月18日　研究論文（学術雑誌）

A newly identified gene Ahed plays essential roles in haematopoiesis through RNA splicing

Takafumi Yokota, Ritsuko Nakai, Masahiro Tokunaga, Mikiro Takaishi, Takao Sudo, Henyun Shi, Yoshiaki Yasumizu, Daisuke Okuzaki, Chikara Kokubu, Sachiyo Tanaka, Katsuyoshi Takaoka, Ayako Yamanishi, Junko Yoshida, Hitomi Watanabe, Gen Kondoh, Kyoji Horie, Naoki Hosen, Shigetoshi Sano, Junji Takeda

Nature communications　Vol. 15　No. 1　p. 5090-5090　2023年8月16日　研究論文（学術雑誌）

Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction.

Kotaro Shimizu, Junichi Kikuta, Yumi Ohta, Yutaka Uchida, Yu Miyamoto, Akito Morimoto, Shinya Yari, Takashi Sato, Takefumi Kamakura, Kazuo Oshima, Ryusuke Imai, Yu-Chen Liu, Daisuke Okuzaki, Tetsuya Hara, Daisuke Motooka, Noriaki Emoto, Hidenori Inohara, Masaru Ishii

Nature communications　Vol. 14　No. 1　p. 4417-4417　2023年8月3日　研究論文（学術雑誌）

A TGF-β-responsive enhancer regulates SRC expression and epithelial-mesenchymal transition-associated cell migration.

Soshi Noshita, Yuki Kubo, Kentaro Kajiwara, Daisuke Okuzaki, Shigeyuki Nada, Masato Okada

Journal of cell science　Vol. 136　No. 15　2023年8月1日　研究論文（学術雑誌）

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto

Cell Reports　Vol. 42　No. 7　2023年7月25日　研究論文（学術雑誌）

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Takashi Orimo, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho

Cell Reports　Vol. 43　No. 4　p. 113981-113981　2023年7月7日　研究論文（学術雑誌）

Whole-blood ribonucleic acid sequencing analysis in methemoglobinemia: a case report.

Chikai Mitsuhara, Yuki Togami, Tomoya Hirose, Shunichiro Nakao, Hiroshi Ito, Hisatake Matsumoto, Hiroshi Ogura, Daisuke Okuzaki, Jun Oda

Journal of medical case reports　Vol. 17　No. 1　p. 238-238　2023年6月10日　研究論文（学術雑誌）

機械学習による新規外傷フェノタイプの同定とプロテオーム解析を用いた病態考察

舘野 丈太郎, 松本 寿健, 杉原 文徳, 瀬尾 茂人, 奥崎 大介, 北村 哲久, 小向 翔, 木戸 善之, 兒嶋 嵩, 戸上 由貴, 片山 祐介, 中川 雄公, 小倉 裕司, 織田 順

日本集中治療医学会雑誌　Vol. 30　No. Suppl.1　p. S456-S456　2023年6月

機械学習による新規外傷フェノタイプの同定とプロテオーム解析を用いた病態考察

舘野 丈太郎, 松本 寿健, 杉原 文徳, 瀬尾 茂人, 奥崎 大介, 北村 哲久, 小向 翔, 木戸 善之, 兒嶋 嵩, 戸上 由貴, 片山 祐介, 中川 雄公, 小倉 裕司, 織田 順

日本集中治療医学会雑誌　Vol. 30　No. Suppl.1　p. S456-S456　2023年6月

Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload

Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Issei Komuro, Akira Kikuchi, Ichiro Shiojima

iScience　p. 107146-107146　2023年6月　研究論文（学術雑誌）

Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation.

Yujiro Naito, Shohei Koyama, Kentaro Masuhiro, Takashi Hirai, Takeshi Uenami, Takako Inoue, Akio Osa, Hirotomo Machiyama, Go Watanabe, Nicolas Sax, Jordan Villa, Yumi Kinugasa-Katayama, Satoshi Nojima, Moto Yaga, Yuki Hosono, Daisuke Okuzaki, Shingo Satoh, Takeshi Tsuda, Yoshimitsu Nakanishi, Yasuhiko Suga, Takayoshi Morita, Kiyoharu Fukushima, Masayuki Nishide, Takayuki Shiroyama, Kotaro Miyake, Kota Iwahori, Haruhiko Hirata, Izumi Nagatomo, Yukihiro Yano, Motohiro Tamiya, Toru Kumagai, Norihiko Takemoto, Hidenori Inohara, Sho Yamasaki, Kazuo Yamashita, Taiki Aoshi, Esra A Akbay, Naoki Hosen, Yasushi Shintani, Hyota Takamatsu, Masahide Mori, Yoshito Takeda, Atsushi Kumanogoh

Science advances　Vol. 9　No. 20　2023年5月19日　研究論文（学術雑誌）

COVID-19 relapse associated with SARS-CoV-2 evasion from CD4+ T-cell recognition in an agammaglobulinemia patient.

Ryo Morita, Ritsuko Kubota-Koketsu, Xiuyuan Lu, Tadahiro Sasaki, Emi E Nakayama, Yu-Chen Liu, Daisuke Okuzaki, Daisuke Motooka, James Badger Wing, Yasunori Fujikawa, Yuji Ichida, Kiyoko Amo, Tetsushi Goto, Junichi Hara, Michinori Shirano, Sho Yamasaki, Tatsuo Shioda

iScience　Vol. 26　No. 5　p. 106685-106685　2023年5月19日　研究論文（学術雑誌）

Long noncoding RNA 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer

Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, George Adrian Calin, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto

Annals of Gastroenterological Surgery　Vol. 7　No. 3　p. 458-470　2023年5月　研究論文（学術雑誌）

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu-Chen Liu, Daisuke Motooka, Yoko Naito, Ayako Takuwa, Fuminori Sugihara, Kentaro Tanaka, James B Wing, Kyuto Sonehara, Yoshihiko Tomofuji, Ho Namkoong, Hiromu Tanaka, Ho Lee, Koichi Fukunaga, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Atsushi Kumanogoh, Yukinori Okada

Nature genetics　Vol. 55　No. 5　p. 753-767　2023年4月24日　研究論文（学術雑誌）

GCN2 kinase-mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln (CUG) charging under amino acid starvation.

Yusuke Tsukamoto, Yumi Nakamura, Makoto Hirata, Daisuke Okuzaki, Ryuichi Sakate, Tomonori Kimura

FEBS letters　Vol. 597　No. 12　p. 1638-1650　2023年4月20日　研究論文（学術雑誌）

Supplementary Table S1 from Human NKp44⁺ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer

Atsuyo Ikeda, Takayuki Ogino, Hisako Kayama, Daisuke Okuzaki, Junichi Nishimura, Shiki Fujino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Kiyoshi Takeda, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

2023年4月4日

Supplementary Figures from Human NKp44⁺ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer

Atsuyo Ikeda, Takayuki Ogino, Hisako Kayama, Daisuke Okuzaki, Junichi Nishimura, Shiki Fujino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Kiyoshi Takeda, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

2023年4月4日

Data from Human NKp44⁺ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer

Atsuyo Ikeda, Takayuki Ogino, Hisako Kayama, Daisuke Okuzaki, Junichi Nishimura, Shiki Fujino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Kiyoshi Takeda, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

2023年4月4日

Tumor-suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer

Hiroaki Itakura, Tsuyoshi Hata, Daisuke Okuzaki, Koki Takeda, Kenji Iso, Yamin Qian, Yoshihiro Morimoto, Tomohiro Adachi, Haruka Hirose, Yuhki Yokoyama, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Takao Hinoi, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto

iScience　Vol. 26　No. 4　p. 106478-106478　2023年4月　研究論文（学術雑誌）

Peripheral-dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy.

Hironari Kawai, Yosuke Osawa, Tomoyuki Tsunoda, Michitaka Matsuda, Miku Okawara, Yuzuru Sakamoto, Tomonari Shimagaki, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Hiroyoshi Doi, Taizo Mori, Taiji Yamazoe, Sachiyo Yoshio, Tadashi Okamura, Masaya Sugiyama, Daisuke Okuzaki, Haruki Komatsu, Ayano Inui, Katsuhiko Yanaga, Toru Ikegami, Tatsuya Kanto

Hepatology research : the official journal of the Japan Society of Hepatology　Vol. 53　No. 4　p. 370-376　2023年4月　研究論文（学術雑誌）

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex

Taiichiro Shirai, Akiko Nakai, Emiko Ando, Jun Fujimoto, Sarah Leach, Takao Arimori, Daisuke Higo, Floris J. van Eerden, Janyerkye Tulyeu, Yu-Chen Liu, Daisuke Okuzaki, Masanori A. Murayama, Haruhiko Miyata, Kazuto Nunomura, Bangzhong Lin, Akiyoshi Tani, Atsushi Kumanogoh, Masahito Ikawa, James B. Wing, Daron M. Standley, Junichi Takagi, Kazuhiro Suzuki

Science Immunology　Vol. 8　No. 81　2023年3月31日　研究論文（学術雑誌）

Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.

Masatoshi Kitakaze, Mamoru Uemura, Tomoaki Hara, Ryota Chijimatsu, Daisuke Motooka, Toshiro Hirai, Masamitsu Konno, Daisuke Okuzaki, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Ken Ofusa, Tsunekazu Mizushima, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii

British journal of cancer　Vol. 128　No. 10　p. 1828-1837　2023年3月3日　研究論文（学術雑誌）

JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors.

Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii

Inflammation and regeneration　Vol. 43　No. 1　p. 18-18　2023年3月3日　研究論文（学術雑誌）

Correction: Multiple knockout mouse and embryonic stem cell models reveal the role of miR-124a in neuronal maturation.

Taro Chaya, Yamato Maeda, Ryo Sugimura, Daisuke Okuzaki, Satoshi Watanabe, Leah R Varner, Daisuke Motooka, Daichi Gyoten, Haruka Yamamoto, Hidemasa Kato, Takahisa Furukawa

The Journal of biological chemistry　Vol. 299　No. 3　p. 103066-103066　2023年3月1日　研究論文（学術雑誌）

Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism.

Haoyang Zhou, Zhiqi Xie, Naosuke Morikawa, Fuminori Sakurai, Hiroyuki Mizuguchi, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

Biochemistry and biophysics reports　Vol. 33　p. 101416-101416　2023年3月　研究論文（学術雑誌）

Single-cell RNA-seq analysis identifies distinct myeloid cells in a case with encephalitis temporally associated with COVID-19 vaccination

Masakazu Ishikawa, Yuki Shimada, Tatsuhiko Ozono, Hisatake Matsumoto, Hiroshi Ogura, Keigo Kihara, Hideki Mochizuki, Tatsusada Okuno, Shuhei Sakakibara, Makoto Kinoshita, Daisuke Okuzaki

Frontiers in Immunology　Vol. 14　2023年2月23日　研究論文（学術雑誌）

ONO-1301 enhances post-transplantation survival of human induced pluripotent stem cell-derived cardiac tissue sheet by promoting angiogenesis.

Xiang Qu, Junjun Li, Li Liu, Jingbo Zhang, Ying Hua, Kota Suzuki, Akima Harada, Masako Ishida, Noriko Yoshida, Daisuke Okuzaki, Yoshiki Sakai, Yoshiki Sawa, Shigeru Miyagawa

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation　Vol. 42　No. 6　p. 716-729　2023年2月10日　研究論文（学術雑誌）

Ovarian high-grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance.

Kansuke Kido, Satoshi Nojima, Daisuke Motooka, Yusuke Nomura, Masaharu Kohara, Kazuaki Sato, Kenji Ohshima, Shinichiro Tahara, Masako Kurashige, Daisuke Umeda, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui, Daisuke Okuzaki, Eiichi Morii

The Journal of pathology　Vol. 260　No. 1　p. 56-70　2023年2月10日　研究論文（学術雑誌）

ASO Visual Abstract: Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.

Takahiro Tomiyama, Shinji Itoh, Norifumi Iseda, Katsuya Toshida, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Yoshihiro Nagao, Kazutoyo Morita, Noboru Harada, Yu-Chen Liu, Daisuke Okuzaki, Kenichi Kohashi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

Annals of surgical oncology　Vol. 30　No. 6　p. 3390-3391　2023年2月10日　研究論文（学術雑誌）

XCR1+ conventional dendritic cell-induced CD4+ T helper 1 cell activation exacerbates cardiac remodeling after ischemic myocardial injury.

Hiroyasu Inui, Makoto Nishida, Michiko Ichii, Hajime Nakaoka, Masumi Asaji, Seiko Ide, Shigeyoshi Saito, Ayami Saga, Takashi Omatsu, Katsunao Tanaka, Kotaro Kanno, Jiuyang Chang, Yinghong Zhu, Takeshi Okada, Daisuke Okuzaki, Takahiro Matsui, Tohru Ohama, Masahiro Koseki, Eiichi Morii, Naoki Hosen, Shizuya Yamashita, Yasushi Sakata

Journal of molecular and cellular cardiology　Vol. 176　p. 68-83　2023年2月3日　研究論文（学術雑誌）

Tumor cell plasticity in endometrioid carcinoma is regulated by neuronal membrane glycoprotein M6-b

Shinya Kusumoto, Jun Ichiro Ikeda, Masako Kurashige, Etsuko Maeno-Fujinami, Shinichiro Tahara, Takahiro Matsui, Satoshi Nojima, Daisuke Okuzaki, Eiichi Morii

Oncology Letters　Vol. 25　No. 2　p. 45-45　2023年2月　研究論文（学術雑誌）

Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

Emi Hashizaki, Miwa Sasai, Daisuke Okuzaki, Tsubasa Nishi, Takashi Kobayashi, Shiroh Iwanaga, Masahiro Yamamoto

mBio　Vol. 14　No. 1　2023年1月30日　研究論文（学術雑誌）

A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Shimon Sakaguchi, Atsushi Kumanogoh, Yukinori Okada, James Badger Wing

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 4　2023年1月24日　研究論文（学術雑誌）

In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma.

Seiji Taniguchi, Takahiro Matsui, Kenji Kimura, Soichiro Funaki, Yu Miyamoto, Yutaka Uchida, Takao Sudo, Junichi Kikuta, Tetsuya Hara, Daisuke Motooka, Yu-Chen Liu, Daisuke Okuzaki, Eiichi Morii, Noriaki Emoto, Yasushi Shintani, Masaru Ishii

Nature communications　Vol. 14　No. 1　p. 143-143　2023年1月17日　研究論文（学術雑誌）

Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.

Takahiro Tomiyama, Shinji Itoh, Norifumi Iseda, Katsuya Toshida, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Yoshihiro Nagao, Kazutoyo Morita, Noboru Harada, Yu-Chen Liu, Daisuke Ozaki, Kenichi Kohashi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

Annals of surgical oncology　Vol. 30　No. 6　p. 3378-3389　2023年1月15日　研究論文（学術雑誌）

Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn's disease.

Takehito Yokoi, Mari Murakami, Takako Kihara, Shigeto Seno, Mitsuru Arase, James Badger Wing, Jonas Nørskov Søndergaard, Ryuichi Kuwahara, Tomohiro Minagawa, Eri Oguro-Igashira, Daisuke Motooka, Daisuke Okuzaki, Ryota Mori, Atsuyo Ikeda, Yuki Sekido, Takahiro Amano, Hideki Iijima, Keiichi Ozono, Tsunekazu Mizushima, Seiichi Hirota, Hiroki Ikeuchi, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 120　No. 1　2023年1月3日　研究論文（学術雑誌）

Transcriptome profiling of anhidrotic eccrine sweat glands reveals that olfactory receptors on eccrine sweat glands regulate perspiration in a ligand-dependent manner

Naoya Murayama, Takafumi Miyaki, Daisuke Okuzaki, Yasuaki Shibata, Takehiko Koji, Asuka Inoue, Junken Aoki, Hideki Hayashi, Yoshimasa Tanaka, Hiroyuki Murota

JID Innovations　Vol. 3　No. 4　p. in press-100196　2023年　研究論文（学術雑誌）

Circulating miR-20b-5p and miR-330-3p are novel biomarkers for progression of atrial fibrillation: Intracardiac/extracardiac plasma sample analysis by small RNA sequencing.

Masahide Harada, Daisuke Okuzaki, Akemi Yamauchi, Shiho Ishikawa, Yoshihiro Nomura, Asuka Nishimura, Yuji Motoike, Masayuki Koshikawa, Keisuke Hitachi, Kunihiro Tsuchida, Kentaro Amano, Atsuo Maekawa, Yasushi Takagi, Eiichi Watanabe, Yukio Ozaki, Hideo Izawa

PloS one　Vol. 18　No. 4　2023年　研究論文（学術雑誌）

Unfolding the Bacterial Transcriptome Landscape Using Oxford Nanopore Technology Direct RNA Sequencing.

Mohamad Al Kadi, Daisuke Okuzaki

Methods in molecular biology (Clifton, N.J.)　Vol. 2632　p. 269-279　2023年　研究論文（学術雑誌）

Single-cell analysis for identification of T-cell clonotypes associated with IgG4 production of autoimmune pancreatitis

Kensuke Shibata, Nao Fujimori, Takamasa Oono, Daisuke Motooka, Daisuke Okuzaki, Koh-Hei Sonoda, Yoshihiro Ogawa, Sho Yamasaki

Gastroenterology Report　Vol. 11　2022年12月30日　研究論文（学術雑誌）

A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis inSteatohepatitic Mice

Ayami Saga, Masahiro Koseki, Kotaro Kanno, Jiuyang Chang, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Masumi Asaji, Katsunao Tanaka, Takashi Omatsu, Sae Nishihara, Yinghong Zhu, Kaori Ito, Hiroaki Hattori, Ikuyo Ichi, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Tohru Ohama, Shungo Hikoso, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata

International Journal of Molecular Sciences　Vol. 23　No. 24　p. 15855-15855　2022年12月13日　研究論文（学術雑誌）

Stimulation of IFN-β responses by aberrant SARS-CoV-2 small viral RNAs acting as RIG-I agonists.

Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tatsuya Suzuki, Tomo Daidoji, Takao Ono, Takaaki Nakaya, Kazuhiko Matsumoto, Daisuke Okuzaki, Yohei Watanabe

iScience　Vol. 26　No. 1　p. 105742-105742　2022年12月7日　研究論文（学術雑誌）

Cell response analysis in SARS-CoV-2 infected bronchial organoids

Emi Sano, Tatsuya Suzuki, Rina Hashimoto, Yumi Itoh, Ayaka Sakamoto, Yusuke Sakai, Akatsuki Saito, Daisuke Okuzaki, Daisuke Motooka, Yukiko Muramoto, Takeshi Noda, Tomohiko Takasaki, Jun-Ichi Sakuragi, Shohei Minami, Takeshi Kobayashi, Takuya Yamamoto, Yasufumi Matsumura, Miki Nagao, Toru Okamoto, Kazuo Takayama

Communications Biology　Vol. 5　No. 1　p. 516-516　2022年12月　研究論文（学術雑誌）

Transcriptional differences between coronavirus disease 2019 and bacterial sepsis.

Hiroshi Ito, Masakazu Ishikawa, Hisatake Matsumoto, Fuminori Sugihara, Daisuke Okuzaki, Haruhiko Hirata, Hiroshi Ogura

Virology journal　Vol. 19　No. 1　p. 198-198　2022年11月28日　研究論文（学術雑誌）

Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b.

Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki

Nature communications　Vol. 13　No. 1　p. 6948-6948　2022年11月14日　研究論文（学術雑誌）

Food odor perception promotes systemic lipid utilization.

Hiroshi Tsuneki, Masanori Sugiyama, Toshihiro Ito, Kiyofumi Sato, Hiroki Matsuda, Kengo Onishi, Koharu Yubune, Yukina Matsuoka, Sanaka Nagai, Towa Yamagishi, Takahiro Maeda, Kosuke Honda, Akira Okekawa, Shiro Watanabe, Keisuke Yaku, Daisuke Okuzaki, Ryota Otsubo, Masanori Nomoto, Kaoru Inokuchi, Takashi Nakagawa, Tsutomu Wada, Teruhito Yasui, Toshiyasu Sasaoka

Nature metabolism　Vol. 4　No. 11　p. 1514-1531　2022年11月14日　研究論文（学術雑誌）

Combination of WFDC2, CHI3L1, and KRT19 in Plasma Defines a Clinically Useful Molecular Phenotype Associated with Prognosis in Critically Ill COVID-19 Patients.

Takeshi Ebihara, Tsunehiro Matsubara, Yuki Togami, Hisatake Matsumoto, Jotaro Tachino, Hiroshi Matsuura, Takashi Kojima, Fuminori Sugihara, Shigeto Seno, Daisuke Okuzaki, Haruhiko Hirata, Hiroshi Ogura

Journal of clinical immunology　Vol. 43　No. 2　p. 1-13　2022年11月4日　研究論文（学術雑誌）

Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway

Sachiko Kobayashi, Shunbun Kita, Daisuke Okuzaki, Yuya Fujishima, Michio Otsuki, Hisashi Kato, Yasuko Nishizawa, Kazuya Miyashita, Chieko Yokoyama, Atsunori Fukuhara, Eiichi Morii, Iichiro Shimomura

iScience　Vol. 25　No. 11　p. 105252-105252　2022年11月　研究論文（学術雑誌）

Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung.

Maiko Naito, Yoshimitsu Nakanishi, Yasutaka Motomura, Hyota Takamatsu, Shohei Koyama, Masayuki Nishide, Yujiro Naito, Mayuko Izumi, Yumiko Mizuno, Yuta Yamaguchi, Satoshi Nojima, Daisuke Okuzaki, Atsushi Kumanogoh

Life science alliance　Vol. 5　No. 11　2022年11月　研究論文（学術雑誌）

Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells.

Yuta Yamaguchi, Yasuhiro Kato, Ryuya Edahiro, Jonas N Søndergaard, Teruaki Murakami, Saori Amiya, Shinichiro Nameki, Yuko Yoshimine, Takayoshi Morita, Yusuke Takeshima, Shuhei Sakakibara, Yoko Naito, Daisuke Motooka, Yu-Chen Liu, Yuya Shirai, Yasutaka Okita, Jun Fujimoto, Haruhiko Hirata, Yoshito Takeda, James B Wing, Daisuke Okuzaki, Yukinori Okada, Atsushi Kumanogoh

JCI insight　Vol. 7　No. 22　2022年10月25日　研究論文（学術雑誌）

Smoking Enhances the Expression of Angiotensin-Converting Enzyme 2 Involved in the Efficiency of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Rigel Suzuki, Yuki Ono, Koji Noshita, Kwang Su Kim, Hayato Ito, Yuhei Morioka, Tomokazu Tamura, Daisuke Okuzaki, Tetsuzo Tagawa, Tomoyoshi Takenaka, Tomoharu Yoshizumi, Teppei Shimamura, Shingo Iwami, Takasuke Fukuhara

Microbiology and immunology　Vol. 67　No. 1　p. 22-31　2022年10月18日　研究論文（学術雑誌）

Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling.

Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio

Scientific reports　Vol. 12　No. 1　p. 16656-16656　2022年10月5日　研究論文（学術雑誌）

Interleukin-17A released from intestinal γδT cells induces cytokine storm in mice with severe dengue

Takeshi Kurosu, Daisuke Okuzaki, Yusuke Sakai, Mohamad Al Kadi, Supranee Phanthanawiboon, Yasusi Ami, Masayuki Shimojima, Tomoki Yoshikawa, Shuetsu Fukushi, Noriyo Nagata, Tadaki Suzuki, Daisuke Kamimura, Masaaki Murakami, Hideki Ebihara, Masayuki Saijo

2022年9月16日

S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis.

Ayaka Nakatani, Takeshi Tsuda, Yohei Maeda, Masaki Hayama, Daisuke Okuzaki, Sho Obata, Toshihiro Kishikawa, Kazuya Takeda, Hidenori Inohara

Allergology international : official journal of the Japanese Society of Allergology　Vol. 72　No. 1　p. 143-150　2022年9月15日　研究論文（学術雑誌）

Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma.

Ryota Chijimatsu, Shogo Kobayashi, Yu Takeda, Masatoshi Kitakaze, Shotaro Tatekawa, Yasuko Arao, Mika Nakayama, Naohiro Tachibana, Taku Saito, Daisuke Ennishi, Shuta Tomida, Kazuki Sasaki, Daisaku Yamada, Yoshito Tomimaru, Hidenori Takahashi, Daisuke Okuzaki, Daisuke Motooka, Takahito Ohshiro, Masateru Taniguchi, Yutaka Suzuki, Kazuhiko Ogawa, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii

iScience　Vol. 25　No. 8　p. 104659-104659　2022年8月19日　研究論文（学術雑誌）

DOCK2 is involved in the host genetics and biology of severe COVID-19.

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu-Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Masatoshi Takagaki, Noah Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Haruhiko Kishima, Hidenori Inohara, Kazunori Tomono, Kazuto Kato, Meiko Takahashi, Fumihiko Matsuda, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-O, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Kazuhiko Katayama, Masumi Ai, Yoshinori Fukui, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada

Nature　Vol. 609　No. 7928　p. 754-760　2022年8月8日　研究論文（学術雑誌）

Development of clinical phenotypes and biological profiles via proteomic analysis of trauma patients

Jotaro Tachino, Hisatake Matsumoto, Fuminori Sugihara, Shigeto Seno, Daisuke Okuzaki, Tetsuhisa Kitamura, Sho Komukai, Yoshiyuki Kido, Takashi Kojima, Yuki Togami, Yusuke Katayama, Yuko Nakagawa, Hiroshi Ogura

Critical Care　Vol. 26　No. 1　p. 241-241　2022年8月6日　研究論文（学術雑誌）

Impact of JMJD6 on intrahepatic cholangiocarcinoma.

Yukiko Kosai-Fujimoto, Shinji Itoh, Kyohei Yugawa, Takasuke Fukuhara, Daisuke Okuzaki, Takeo Toshima, Noboru Harada, Yoshinao Oda, Tomoharu Yoshizumi, Masaki Mori

Molecular and clinical oncology　Vol. 17　No. 2　p. 131-131　2022年8月　研究論文（学術雑誌）

Up-regulated LRRN2 expression as a marker for graft quality in living donor liver transplantation.

Takahiro Tomiyama, Takuya Yamamoto, Shokichi Takahama, Takeo Toshima, Shinji Itoh, Noboru Harada, Mototsugu Shimokawa, Daisuke Okuzaki, Masaki Mori, Tomoharu Yoshizumi

Hepatology communications　Vol. 6　No. 10　p. 2836-2849　2022年7月27日　研究論文（学術雑誌）

Multiple knockout mouse and embryonic stem cell models reveal the role of miR-124a in neuronal maturation.

Taro Chaya, Maeda Yamato, Ryo Sugimura, Daisuke Okuzaki, Satoshi Watanabe, Leah R Varner, Daisuke Motooka, Daichi Gyoten, Haruka Yamamoto, Hidemasa Kato, Takahisa Furukawa

The Journal of biological chemistry　Vol. 298　No. 9　p. 102293-102293　2022年7月19日　研究論文（学術雑誌）

Clinical Significance of Interferon Signaling Based on mRNA-microRNA Integration and Plasma Protein Analyses in Critically Ill COVID-19 Patients.

Yuki Togami, Hisatake Matsumoto, Jumpei Yoshimura, Tsunehiro Matsubara, Takeshi Ebihara, Hiroshi Matsuura, Yumi Mitsuyama, Takashi Kojima, Masakazu Ishikawa, Fuminori Sugihara, Haruhiko Hirata, Daisuke Okuzaki, Hiroshi Ogura

Molecular therapy. Nucleic acids　Vol. 29　p. 343-353　2022年7月13日　研究論文（学術雑誌）

Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response.

Yuriko Otake-Kasamoto, Hisako Kayama, Toshihiro Kishikawa, Shinichiro Shinzaki, Taku Tashiro, Takahiro Amano, Mizuki Tani, Takeo Yoshihara, Bo Li, Haruka Tani, Li Liu, Akio Hayashi, Daisuke Okuzaki, Daisuke Motooka, Shota Nakamura, Yukinori Okada, Hideki Iijima, Kiyoshi Takeda, Tetsuo Takehara

The Journal of experimental medicine　Vol. 219　No. 7　2022年7月4日　研究論文（学術雑誌）

Impaired differentiation potential of CD34-positive cells derived from mouse hair follicles after long-term culture.

Yukiteru Ouji, Masayasu Misu, Tomotaka Kitamura, Daisuke Okuzaki, Masahide Yoshikawa

Scientific reports　Vol. 12　No. 1　p. 11011-11011　2022年6月30日　研究論文（学術雑誌）

Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.

Kentaro Masuhiro, Motohiro Tamiya, Kosuke Fujimoto, Shohei Koyama, Yujiro Naito, Akio Osa, Takashi Hirai, Hidekazu Suzuki, Norio Okamoto, Takayuki Shiroyama, Kazumi Nishino, Yuichi Adachi, Takuro Nii, Yumi Kinugasa-Katayama, Akiko Kajihara, Takayoshi Morita, Seiya Imoto, Satoshi Uematsu, Takuma Irie, Daisuke Okuzaki, Taiki Aoshi, Yoshito Takeda, Toru Kumagai, Tomonori Hirashima, Atsushi Kumanogoh

JCI insight　Vol. 7　No. 9　2022年4月7日　研究論文（学術雑誌）

血管・脂肪由来分泌因子Favineの機能解析

小林 祥子, 加藤 恒, 喜多 俊文, 奥崎 大介, 藤島 裕也, 西澤 恭子, 大月 道夫, 福原 淳範, 森井 英一, 下村 伊一郎

日本内分泌学会雑誌　Vol. 98　No. 1　p. 393-393　2022年4月

Corrigendum to: Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice.

Marwa Ali El Hussien, Chao-Yuan Tsai, Yuhkoh Satouh, Daisuke Motooka, Daisuke Okuzaki, Masahito Ikawa, Hitoshi Kikutani, Shuhei Sakakibara

International immunology　Vol. 34　No. 4　p. 225-225　2022年3月25日　研究論文（学術雑誌）

Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice

Marwa Ali El Hussien, Chao-Yuan Tsai, Yuhkoh Satouh, Daisuke Motooka, Daisuke Okuzaki, Masahito Ikawa, Hitoshi Kikutani, Shuhei Sakakibara

International Immunology　Vol. 34　No. 4　p. 207-223　2022年3月25日　研究論文（学術雑誌）

XCR1陽性樹状細胞によるCD4 T Helper-1の活性化は心筋梗塞後のリモデリングを悪化させる(XCR1+ Dendritic Cell-Induced CD4 T Helper-1 Activation Leads to Exacerbation of Remodeling after Myocardial Infarction)

Inui Hiroyasu, Nishida Makoto, Asaji Masumi, Ide Seiko, Saito Shigeyoshi, Okuzaki Daisuke, Matsui Takahiro, Ichii Michiko, Saga Ayami, Kanno Kotaro, Okada Takeshi, Koseki Masahiro, Ohama Tohru, Yamashita Shizuya, Sakata Yasushi

日本循環器学会学術集会抄録集　Vol. 86回　p. YIA-2　2022年3月

ペマフィブラートは脂肪肝炎関連心筋症モデルにおいてNLRP3インフラマソームの活性化を抑制する(Pemafibrate Suppresses NLRP3 Inflammasome Activation in a Novel Model of Cholesterol-induced, Steatohepatitis-related Cardiomyopathy)

冠野 昂太郎, 小関 正博, 常 久洋, 嵯峨 礼美, 乾 洋勉, 岡田 健志, 田中 克尚, 朝治 真澄, 朱 穎こう, 井手 盛子, 肥後 友彰, 齋藤 茂芳, 奥崎 大介, 大濱 透, 西田 誠, 鎌田 佳宏, 小野 正文, 西原 利治, 山下 静也, 坂田 泰史

日本循環器学会学術集会抄録集　Vol. 86回　p. PJ03-1　2022年3月

Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo.

Maki Uenaka, Erika Yamashita, Junichi Kikuta, Akito Morimoto, Tomoka Ao, Hiroki Mizuno, Masayuki Furuya, Tetsuo Hasegawa, Hiroyuki Tsukazaki, Takao Sudo, Keizo Nishikawa, Daisuke Okuzaki, Daisuke Motooka, Nobuyoshi Kosaka, Fuminori Sugihara, Thomas Boettger, Thomas Braun, Takahiro Ochiya, Masaru Ishii

Nature communications　Vol. 13　No. 1　p. 1066-1066　2022年2月24日　研究論文（学術雑誌）

Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy.

Kotaro Kanno, Masahiro Koseki, Jiuyang Chang, Ayami Saga, Hiroyasu Inui, Takeshi Okada, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Seiko Ide, Shigeyoshi Saito, Tomoaki Higo, Daisuke Okuzaki, Tohru Ohama, Makoto Nishida, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Shizuya Yamashita, Yasushi Sakata

Scientific reports　Vol. 12　No. 1　p. 2996-2996　2022年2月22日　研究論文（学術雑誌）

The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB.

Tetsuya Kimura, Yoshitomo Hayama, Daisuke Okuzaki, Shigeyuki Nada, Masato Okada

The Journal of biological chemistry　Vol. 298　No. 3　p. 101744-101744　2022年2月17日　研究論文（学術雑誌）

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.

Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, Shimon Sakaguchi

Proceedings of the National Academy of Sciences of the United States of America　Vol. 119　No. 7　2022年2月15日　研究論文（学術雑誌）

Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine.

Siddhika Pareek, Xenia Sanchenkova, Taiki Sakaguchi, Mari Murakami, Ryu Okumura, Hisako Kayama, Saya Kawauchi, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, Tadamitsu Kishimoto, Kiyoshi Takeda

Genes to cells : devoted to molecular & cellular mechanisms　Vol. 27　No. 4　p. 243-253　2022年1月25日　研究論文（学術雑誌）

Resistin Associated With Cytokines and Endothelial Cell Adhesion Molecules Is Related to Worse Outcome in COVID-19.

Takeshi Ebihara, Hisatake Matsumoto, Tsunehiro Matsubara, Yuki Togami, Shunichiro Nakao, Hiroshi Matsuura, Shinya Onishi, Takashi Kojima, Fuminori Sugihara, Daisuke Okuzaki, Haruhiko Hirata, Hitoshi Yamamura, Hiroshi Ogura

Frontiers in immunology　Vol. 13　p. 830061-830061　2022年　研究論文（学術雑誌）

Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model.

Moe Takemura, Masaya Yamaguchi, Momoko Kobayashi, Tomoko Sumitomo, Yujiro Hirose, Daisuke Okuzaki, Masayuki Ono, Daisuke Motooka, Kana Goto, Masanobu Nakata, Narikazu Uzawa, Shigetada Kawabata

Frontiers in cellular and infection microbiology　Vol. 12　p. 844000-844000　2022年　研究論文（学術雑誌）

UNAGI: Yeast Transcriptome Reconstruction and Gene Discovery Using Nanopore Sequencing.

Mohamad Al Kadi, Nicolas Jung, Daisuke Okuzaki

Methods in molecular biology (Clifton, N.J.)　Vol. 2477　p. 79-89　2022年　研究論文（学術雑誌）

Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF.

Zhiqi Xie, Takahiro Kawasaki, Haoyang Zhou, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

Frontiers in pharmacology　Vol. 13　p. 873792-873792　2022年　研究論文（学術雑誌）

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki

Nature communications　Vol. 13　No. 1　p. 4230-4230　2021年12月21日　研究論文（学術雑誌）

Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy.

Hironari Kawai, Yosuke Osawa, Michitaka Matsuda, Tomoyuki Tsunoda, Keisuke Yanagida, Daisuke Hishikawa, Miku Okawara, Yuzuru Sakamoto, Tomonari Shimagaki, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Kana Hashi, Hiroyoshi Doi, Taizo Mori, Taiji Yamazoe, Sachiyo Yoshio, Masaya Sugiyama, Daisuke Okuzaki, Haruki Komatsu, Ayano Inui, Miwa Tamura-Nakano, Chinatsu Oyama, Hideo Shindou, Hironori Kusano, Masayoshi Kage, Toru Ikegami, Katsuhiko Yanaga, Tatsuya Kanto

Hepatology (Baltimore, Md.)　Vol. 76　No. 1　p. 112-125　2021年12月2日　研究論文（学術雑誌）

Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression.

Yuichiro Tsuji, Naosuke Nonoguchi, Daisuke Okuzaki, Yusuke Wada, Daisuke Motooka, Yuki Hirota, Taichiro Toho, Nobuhiko Yoshikawa, Motomasa Furuse, Shinji Kawabata, Shin-Ichi Miyatake, Hiroyuki Nakamura, Ryohei Yamamoto, Shota Nakamura, Toshihiko Kuroiwa, Masahiko Wanibuchi

Scientific reports　Vol. 11　No. 1　p. 22110-22110　2021年11月11日　研究論文（学術雑誌）

Direct RNA Sequencing Unfolds the Complex Transcriptome of Vibrio parahaemolyticus.

Mohamad Al Kadi, Eiji Ishii, Dang Tat Truong, Daisuke Motooka, Shigeaki Matsuda, Tetsuya Iida, Toshio Kodama, Daisuke Okuzaki

mSystems　Vol. 6　No. 6　2021年11月9日　研究論文（学術雑誌）

Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy.

Haruki Shinomiya, Hisakazu Kato, Yuki Kuramoto, Nozomi Watanabe, Toshihiro Tsuruda, Tadaaki Arimura, Yohei Miyashita, Yoshiki Miyasaka, Tomoji Mashimo, Ayako Takuwa, Daisuke Motooka, Daisuke Okuzaki, Ken Matsuoka, Osamu Tsukamoto, Hideyuki Hakui, Noriaki Yamada, Jong-Kook Lee, Hidetaka Kioka, Masafumi Kitakaze, Seiji Takashima, Yasushi Sakata, Yoshihiro Asano

FASEB journal : official publication of the Federation of American Societies for Experimental Biology　Vol. 35　No. 11　2021年11月　研究論文（学術雑誌）

The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.

Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, Murat Tekguc, Hozaifa Metwally, Yu-Chen Liu, Daisuke Okuzaki, Yohannes Gemechu, Sujin Kang, Tadamitsu Kishimoto

Cancer letters　Vol. 520　p. 295-306　2021年11月1日　研究論文（学術雑誌）

A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells.

Takashi Takeda, Yuhki Yokoyama, Hidekazu Takahashi, Daisuke Okuzaki, Kaho Asai, Hiroaki Itakura, Norikatsu Miyoshi, Shogo Kobayashi, Mamoru Uemura, Toshitsugu Fujita, Hiroo Ueno, Masaki Mori, Yuichiro Doki, Hodaka Fujii, Hidetoshi Eguchi, Hirofumi Yamamoto

British journal of cancer　Vol. 126　No. 1　p. 109-119　2021年10月27日　研究論文（学術雑誌）

Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling.

Kenji Ohshima, Ryo Oi, Daisuke Okuzaki, Daisuke Motooka, Masakazu Shinohara, Satoshi Nojima, Eiichi Morii

British journal of cancer　Vol. 125　No. 12　p. 1699-1711　2021年10月23日　研究論文（学術雑誌）

Osteoclasts adapt to physioxia perturbation through DNA demethylation.

Keizo Nishikawa, Shigeto Seno, Toshitada Yoshihara, Ayako Narazaki, Yuki Sugiura, Reito Shimizu, Junichi Kikuta, Reiko Sakaguchi, Norio Suzuki, Norihiko Takeda, Hiroaki Semba, Masamichi Yamamoto, Daisuke Okuzaki, Daisuke Motooka, Yasuhiro Kobayashi, Makoto Suematsu, Haruhiko Koseki, Hideo Matsuda, Masayuki Yamamoto, Seiji Tobita, Yasuo Mori, Masaru Ishii

EMBO reports　Vol. 22　No. 12　2021年10月18日　研究論文（学術雑誌）

Nicotinamide N-methyltransferase is related to MELF pattern invasion in endometrioid carcinoma.

Shinichiro Tahara, Satoshi Nojima, Kenji Ohshima, Yumiko Hori, Kazuaki Sato, Masako Kurashige, Takahiro Matsui, Daisuke Okuzaki, Eiichi Morii

Cancer medicine　Vol. 10　No. 23　p. 8630-8640　2021年10月16日　研究論文（学術雑誌）

The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells.

Haruka Tani, Bo Li, Takashi Kusu, Ryu Okumura, Junichi Nishimura, Daisuke Okuzaki, Daisuke Motooka, Shoya Arakawa, Asuka Mori, Terukazu Yoshihara, Takayuki Ogino, Shih-Han Tsai, Yoki Furuta, Masato Muneta, Shota Nakamura, Eiichiro Fukusaki, Kimiko Yamamoto, Hideo Yagita, Hisako Kayama, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America　Vol. 118　No. 39　2021年9月28日　研究論文（学術雑誌）

Repetitive spikes of glucose and lipid induce senescence-like phenotypes of bone marrow stem cells through H3K27me3 demethylase-mediated epigenetic regulation.

Keita Horitani, Masayoshi Iwasaki, Hiroshi Kishimoto, Kensaku Wada, Miyuki Nakano, Haengnam Park, Yasushi Adachi, Daisuke Motooka, Daisuke Okuzaki, Ichiro Shiojima

American journal of physiology. Heart and circulatory physiology　Vol. 321　No. 5　p. H920-H932-H932　2021年9月17日　研究論文（学術雑誌）

Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity.

Taro Chaya, Hiroshi Ishikane, Leah R Varner, Yuko Sugita, Yamato Maeda, Ryotaro Tsutsumi, Daisuke Motooka, Daisuke Okuzaki, Takahisa Furukawa

Human molecular genetics　Vol. 31　No. 4　p. 535-547　2021年9月11日　研究論文（学術雑誌）

Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats.

Teruyuki Ishikura, Makoto Kinoshita, Mikito Shimizu, Yoshiaki Yasumizu, Daisuke Motooka, Daisuke Okuzaki, Kazuya Yamashita, Hisashi Murata, Shohei Beppu, Toru Koda, Satoru Tada, Naoyuki Shiraishi, Yasuko Sugiyama, Katsuichi Miyamoto, Susumu Kusunoki, Tomoyuki Sugimoto, Atsushi Kumanogoh, Tatsusada Okuno, Hideki Mochizuki

Journal of neuroinflammation　Vol. 18　No. 1　p. 181-181　2021年8月21日　研究論文（学術雑誌）

D-Serine mediates cellular proliferation for kidney remodeling

Atsushi Hesaka, Yusuke Tsukamoto, Shigeyuki Nada, Masataka Kawamura, Naotsugu Ichimaru, Shinsuke Sakai, Maiko Nakane, Masashi Mita, Daisuke Okuzaki, Masato Okada, Yoshitaka Isaka, Tomonori Kimura

Kidney360　Vol. 2　No. 10　p. 10.34067/KID.0000832021-10.34067/KID.0000832021　2021年8月16日　研究論文（学術雑誌）

IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity.

Yasuhiko Suga, Izumi Nagatomo, Yuhei Kinehara, Shohei Koyama, Daisuke Okuzaki, Akio Osa, Yujiro Naito, Hyota Takamatsu, Masayuki Nishide, Satoshi Nojima, Daisuke Ito, Takeshi Tsuda, Takeshi Nakatani, Yoshimitsu Nakanishi, Yu Futami, Taro Koba, Shingo Satoh, Yuki Hosono, Kotaro Miyake, Kiyoharu Fukushima, Takayuki Shiroyama, Kota Iwahori, Haruhiko Hirata, Yoshito Takeda, Atsushi Kumanogoh

Journal of immunology (Baltimore, Md. : 1950)　Vol. 207　No. 5　p. 1456-1467　2021年8月11日　研究論文（学術雑誌）

Diet-induced hepatic steatosis and fibrosis were improved by a selective ppara modulator, pemafibrate, in STZ -induced diabetic mice

J. Chang, M. Koseki, K. Kanno, A. Saga, T. Okada, K. Tanaka, Y. Kamada, T. Higo, D. Okuzaki, H. Inui, M. Asaji, Y. Zhu, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata

Atherosclerosis　Vol. 331　p. e173-e173　2021年8月　研究論文（学術雑誌）

Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.

Gyanu Parajuli, Murat Tekguc, James B Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, Yoshihiro Nishikawa, Hozaifa Metwally, Yuzo Kodama, Shinya Tanaka, Hisataka Sabe, Toshihide Yamashita, Shimon Sakaguchi, Tadamitsu Kishimoto, Shigeru Hashimoto

Cancer immunology research　Vol. 9　No. 8　p. 862-876　2021年8月　研究論文（学術雑誌）

Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.

Yosuke Funato, Daisuke Yamazaki, Daisuke Okuzaki, Nobuhiko Yamamoto, Hiroaki Miki

Nature communications　Vol. 12　No. 1　p. 3683-3683　2021年6月17日　研究論文（学術雑誌）

Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.

Takanori Adachi, Wantong Zhao, Kazumasa Minami, Yuhki Yokoyama, Daisuke Okuzaki, Rika Kondo, Yutaka Takahashi, Keisuke Tamari, Yuji Seo, Fumiaki Isohashi, Hirofumi Yamamoto, Masahiko Koizumi, Kazuhiko Ogawa

Journal of radiation research　Vol. 62　No. 5　p. 764-772　2021年6月14日　研究論文（学術雑誌）

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions.

Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, Ryosuke Yoshizawa, Takashi Nagasawa, Yuzuru Kanakura, Kazuyo Moro, Masaru Ishii

The Journal of experimental medicine　Vol. 218　No. 5　2021年5月3日　研究論文（学術雑誌）

SLPI is a critical mediator that controls PTH-induced bone formation.

Akito Morimoto, Junichi Kikuta, Keizo Nishikawa, Takao Sudo, Maki Uenaka, Masayuki Furuya, Tetsuo Hasegawa, Kunihiko Hashimoto, Hiroyuki Tsukazaki, Shigeto Seno, Akira Nakamura, Daisuke Okuzaki, Fuminori Sugihara, Akinori Ninomiya, Takeshi Yoshimura, Ryoko Takao-Kawabata, Hideo Matsuda, Masaru Ishii

Nature communications　Vol. 12　No. 1　p. 2136-2136　2021年4月9日　研究論文（学術雑誌）

Hypoxia transactivates cholecystokinin gene expression in 3D-engineered muscle.

Tomohiro Nakamura, Shunya Takagi, Daisuke Okuzaki, Seika Matsui, Toshia Fujisato

Journal of bioscience and bioengineering　Vol. 132　No. 1　p. 64-70　2021年4月8日　研究論文（学術雑誌）

The Up-Regulation of CXCL12-CXCR4 Axis By Radiotherapy Could Accelerate Glioma Progression

Tsuji Y, Nonoguchi N, Okuzaki D, Wada Y, Motooka D, Hirota Y, Toho T, Yoshikawa N, Furuse M, Kawabata S, Miyatake S, Nakamura H, Yamamato R, Wanibuchi M

2021年4月　研究論文（学術雑誌）

CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.

Kentaro Kajiwara, Shotaro Yamano, Kazuhiro Aoki, Daisuke Okuzaki, Kunio Matsumoto, Masato Okada

Life science alliance　Vol. 4　No. 4　p. e202000832-e202000832　2021年4月　研究論文（学術雑誌）

Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface.

Yujiro Hirose, Masaya Yamaguchi, Tomoko Sumitomo, Masanobu Nakata, Tomoki Hanada, Daisuke Okuzaki, Daisuke Motooka, Yasushi Mori, Hiroshi Kawasaki, Alison Coady, Satoshi Uchiyama, Masanobu Hiraoka, Raymond H Zurich, Masayuki Amagai, Victor Nizet, Shigetada Kawabata

Cell reports　Vol. 34　No. 13　p. 108924-108924　2021年3月30日　研究論文（学術雑誌）

β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells.

Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada

Communications biology　Vol. 4　No. 1　p. 357-357　2021年3月19日　研究論文（学術雑誌）

Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.

Hiroshi Matsuura, Hisatake Matsumoto, Daisuke Okuzaki, Kentaro Shimizu, Hiroshi Ogura, Takeshi Ebihara, Tsunehiro Matsubara, Shin-Ichi Hirano, Takeshi Shimazu

The Journal of surgical research　Vol. 263　p. 63-70　2021年2月24日　研究論文（学術雑誌）

Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.

Yasuhiro Shingai, Takafumi Yokota, Daisuke Okuzaki, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Tomoaki Ueda, Takayuki Ozawa, Ritsuko Nakai, Akira Tanimura, Michiko Ichii, Hirohiko Shibayama, Yuzuru Kanakura, Naoki Hosen

Stem cells (Dayton, Ohio)　Vol. 39　No. 6　p. 723-736　2021年2月4日　研究論文（学術雑誌）

Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.

Masaya Yamaguchi, Hpoo Pwint Myo Win, Kotaro Higashi, Masayuki Ono, Yujiro Hirose, Daisuke Motooka, Daisuke Okuzaki, Mya Mya Aye, Moh Moh Htun, Hlaing Myat Thu, Shigetada Kawabata

Microbial genomics　Vol. 7　No. 2　p. 1-14　2021年2月　研究論文（学術雑誌）

Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function

Yasuhiro Nagate, Sachiko Ezoe, Jiro Fujita, Daisuke Okuzaki, Daisuke Motooka, Tomohiko Ishibashi, Michiko Ichii, Akira Tanimura, Masako Kurashige, Eiichi Morii, Takuya Fukushima, Youko Suehiro, Takafumi Yokota, Hirohiko Shibayama, Kenji Oritani, Yuzuru Kanakura

Leukemia　Vol. 35　No. 1　p. 107-118　2021年1月20日　研究論文（学術雑誌）

Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis.

Takeshi Ebihara, Hisatake Matsumoto, Tsunehiro Matsubara, Yuki Togami, Shunichiro Nakao, Hiroshi Matsuura, Takashi Kojima, Fuminori Sugihara, Daisuke Okuzaki, Haruhiko Hirata, Hitoshi Yamamura, Hiroshi Ogura

Frontiers in immunology　Vol. 12　p. 798338-798338　2021年　研究論文（学術雑誌）

Oligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in ulcerative colitis.

Shuko Iwatani, Shinichiro Shinzaki, Takahiro Amano, Yuriko Otake, Mizuki Tani, Takeo Yoshihara, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Daisuke Okuzaki, Tsunekazu Mizushima, Eiji Miyoshi, Hideki Iijima, Tetsuo Takehara

Journal of gastroenterology and hepatology　Vol. 35　No. 12　p. 2158-2169　2020年12月　研究論文（学術雑誌）

HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma.

Mitsuyo Tone, Shinichiro Tahara, Satoshi Nojima, Daisuke Motooka, Daisuke Okuzaki, Eiichi Morii

Cancer science　Vol. 111　No. 10　p. 3953-3961　2020年10月　研究論文（学術雑誌）

Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes.

Yasuaki Kohama, Shuichiro Higo, Yuki Masumura, Mikio Shiba, Takumi Kondo, Takamaru Ishizu, Tomoaki Higo, Satoki Nakamura, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata

Scientific reports　Vol. 10　No. 1　p. 15348-15348　2020年9月18日　研究論文（学術雑誌）

Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor.

Kazuya Iwamoto, Hidekazu Takahashi, Daisuke Okuzaki, Hideo Osawa, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi

British journal of cancer　Vol. 123　No. 6　p. 955-964　2020年9月　研究論文（学術雑誌）

総説 エクソソームmicroRNAと乳癌

柴田 雅朗, 谷口 高平, 奥崎 大介, 近藤 洋一

乳癌基礎研究　Vol. 28　p. 63-69　2020年8月

Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.

Jun Toda, Michiko Ichii, Kenji Oritani, Hirohiko Shibayama, Akira Tanimura, Hideaki Saito, Takafumi Yokota, Daisuke Motooka, Daisuke Okuzaki, Yuichi Kitai, Ryuta Muromoto, Jun-Ichi Kashiwakura, Tadashi Matsuda, Naoki Hosen, Yuzuru Kanakura

Oncogene　Vol. 39　No. 34　p. 5601-5615　2020年8月　研究論文（学術雑誌）

FAM111B enhances proliferation of KRAS-driven lung adenocarcinoma by degrading p16.

Keisuke Kawasaki, Satoshi Nojima, Sachiko Hijiki, Shinichiro Tahara, Kenji Ohshima, Takahiro Matsui, Yumiko Hori, Masako Kurashige, Daisuke Umeda, Hiroki Kiyokawa, Kansuke Kido, Daisuke Okuzaki, Eiichi Morii

Cancer science　Vol. 111　No. 7　p. 2635-2646　2020年7月　研究論文（学術雑誌）

TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.

Taiki Sakaguchi, Ryu Okumura, Chisato Ono, Daisuke Okuzaki, Takafumi Kawai, Yoshifumi Okochi, Natsuko Tanimura, Mari Murakami, Hisako Kayama, Eiji Umemoto, Hidetaka Kioka, Tomohito Ohtani, Yasushi Sakata, Kensuke Miyake, Yasushi Okamura, Yoshihiro Baba, Kiyoshi Takeda

Cell reports　Vol. 31　No. 10　p. 107755-107755　2020年6月9日　研究論文（学術雑誌）

Generation of human bronchial organoids for SARS-CoV-2 research

Tatsuya Suzuki, Yumi Itoh, Yusuke Sakai, Akatsuki Saito, Daisuke Okuzaki, Daisuke Motooka, Shohei Minami, Takeshi Kobayashi, Takuya Yamamoto, Toru Okamoto, Kazuo Takayama

2020年5月26日

miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells

Yoshihiro Morimoto, Tsunekazu Mizushima, Xin Wu, Daisuke Okuzaki, Yuhki Yokoyama, Akira Inoue, Tsuyoshi Hata, Haruka Hirose, Yamin Qian, Jiaqi Wang, Norikatsu Miyoshi, Hidekazu Takahashi, Naotsugu Haraguchi, Chu Matsuda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto

British Journal of Cancer　Vol. 122　No. 7　p. 1037-1049　2020年3月31日　研究論文（学術雑誌）

DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer (vol 41, pg 303, 2020)

Shunichiro Makino, Hidekazu Takahashi, Daisuke Okuzaki, Norikatsu Miyoshi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

CARCINOGENESIS　Vol. 41　No. 3　p. 394-396　2020年3月

Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis

Takeshi Tsuda, Masayuki Nishide, Yohei Maeda, Yoshitomo Hayama, Shohei Koyama, Satoshi Nojima, Hyota Takamatsu, Daisuke Okuzaki, Takayoshi Morita, Takeshi Nakatani, Yasuhiro Kato, Yoshimitsu Nakanishi, Yu Futami, Yasuhiko Suga, Yujiro Naito, Hachiro Konaka, Shingo Satoh, Maiko Naito, Mayuko Izumi, Sho Obata, Ayaka Nakatani, Takashi Shikina, Kazuya Takeda, Masaki Hayama, Hidenori Inohara, Atsushi Kumanogoh

Journal of Allergy and Clinical Immunology　Vol. 145　No. 3　p. 843-854.e4　2020年3月　研究論文（学術雑誌）

c-Src promotes tumor progression through downregulation of microRNA-129-1-3p

Daisuke Okuzaki, Tomoe Yamauchi, Fumie Mitani, Mamiko Miyata, Yuichi Ninomiya, Risayo Watanabe, Hiroki Akamatsu, Chitose Oneyama

CANCER SCIENCE　Vol. 111　No. 2　p. 418-428　2020年2月　研究論文（学術雑誌）

大腸癌における三次元ゲノム構造を介したKLF5遺伝子発現制御メカニズム

横山雄起, 武田和, 藤田敏次, 奥崎大介, 杉山真美, 浅井香穂, 高橋秀和, 藤井穂高, 森正樹, 山本浩文, 山本浩文

日本癌学会学術総会抄録集(Web)　Vol. 79th　p. 338-338　2020年

Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice.

Jiuyang Chang, Masahiro Koseki, Ayami Saga, Kotaro Kanno, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Ikuyo Ichi, Tohru Ohama, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata

Frontiers in endocrinology　Vol. 11　p. 614692-614692　2020年　研究論文（学術雑誌）

Erratum: DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer (Carcinogenesis (bgz157) DOI: 10.1093/carcin/bgz157)

Makino, S., Takahashi, H., Okuzaki, D., Miyoshi, N., Haraguchi, N., Hata, T., Matsuda, C., Yamamoto, H., Mizushima, T., Mori, M., Doki, Y.

Carcinogenesis　Vol. 41　No. 3　p. 394-396　2020年　研究論文（学術雑誌）

Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway.

Maho Morimatsu, Erika Yamashita, Shigeto Seno, Takao Sudo, Junichi Kikuta, Hiroki Mizuno, Daisuke Okuzaki, Daisuke Motooka, Masaru Ishii

Inflammation and regeneration　Vol. 40　No. 1　p. 15-15　2020年　研究論文（学術雑誌）

Human NKp44⁺ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer

Ikeda, A., Ogino, T., Kayama, H., Okuzaki, D., Nishimura, J., Fujino, S., Miyoshi, N., Takahashi, H., Uemura, M., Matsuda, C., Yamamoto, H., Takeda, K., Mizushima, T., Mori, M., Doki, Y.

Cancer immunology research　Vol. 8　No. 6　p. 724-731　2020年　研究論文（学術雑誌）

Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.

Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Keisuke Kawasaki, Yumiko Hori, Moyu Taniguchi, Yutaka Umakoshi, Daisuke Okuzaki, Naoki Wada, Jun-Ichiro Ikeda, Eiichiro Fukusaki, Eiichi Morii

Nature metabolism　Vol. 2　No. 1　p. 81-96　2020年1月　研究論文（学術雑誌）

Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer

Nagasawa, M., Tomimatsu, K., Terada, K., Kondo, K., Miyazaki, K., Miyazaki, M., Motooka, D., Okuzaki, D., Yoshida, T., Kageyama, S., Kawamoto, H., Kawauchi, A., Agata, Y.

Biochemical and Biophysical Research Communications　Vol. 526　No. 1　p. 128-134　2020年　研究論文（学術雑誌）

Analysis of genes linked to depressive-like behaviors in interleukin-18-deficient mice: Gene expression profiles in the brain

Yamanishi, K., Hashimoto, T., Miyauchi, M., Mukai, K., Ikubo, K., Uwa, N., Watanabe, Y., Ikawa, T., Okuzaki, D., Okamura, H., Yamanishi, H., Matsunaga, H.

Biomedical Reports　Vol. 12　No. 1　p. 3-10　2020年　研究論文（学術雑誌）

UNAGI: an automated pipeline for nanopore full-length cDNA sequencing uncovers novel transcripts and isoforms in yeast

Al kadi, M., Jung, N., Ito, S., Kameoka, S., Hishida, T., Motooka, D., Nakamura, S., Iida, T., Okuzaki, D.

Functional and Integrative Genomics　Vol. 20　No. 4　p. 523-536　2020年　研究論文（学術雑誌）

Indian hedgehog in craniofacial neural crest cells links to skeletal malocclusion by regulating associated cartilage formation and gene expression

Amano, K., Okuzaki, D., Aikawa, T., Kogo, M.

FASEB Journal　Vol. 34　No. 5　p. 6791-6807　2020年　研究論文（学術雑誌）

c-Src promotes tumor progression through downregulation of microRNA-129-1-3p

Okuzaki, D., Yamauchi, T., Mitani, F., Miyata, M., Ninomiya, Y., Watanabe, R., Akamatsu, H., Oneyama, C.

Cancer Science　Vol. 111　No. 2　p. 418-428　2020年　研究論文（学術雑誌）

Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells

Yoshimura, Y., Okuzaki, D.

Data in Brief　Vol. 29　p. 105228-105228　2020年　研究論文（学術雑誌）

In vivo dynamic analysis of BMP-2-induced ectopic bone formation

Hashimoto, K., Kaito, T., Furuya, M., Seno, S., Okuzaki, D., Kikuta, J., Tsukazaki, H., Matsuda, H., Yoshikawa, H., Ishii, M.

Scientific Reports　Vol. 10　No. 1　p. 4751-4751　2020年　研究論文（学術雑誌）

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Ichii, M., Oritani, K., Toda, J., Saito, H., Shi, H., Shibayama, H., Motooka, D., Kitai, Y., Muromoto, R., Kashiwakura, J.-I., Saitoh, K., Okuzaki, D., Matsuda, T., Kanakura, Y.

Haematologica　Vol. 105　No. 5　p. 424-436　2020年　研究論文（学術雑誌）

SDPRは子宮体部類内膜癌においてILKを介してALDH1を制御する

田原紳一郎, 野島聡, 大島健司, 堀由美子, 倉重真沙子, 和田直樹, 本山雄一, 奥崎大介, 池田純一郎, 森井英一

日本癌学会学術総会抄録集(Web)　Vol. 79th　2020年

DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer

Makino, S., Takahashi, H., Okuzaki, D., Miyoshi, N., Haraguchi, N., Hata, T., Matsuda, C., Yamamoto, H., Mizushima, T., Mori, M., Doki, Y.

Carcinogenesis　Vol. 41　No. 3　p. 303-312　2020年　研究論文（学術雑誌）

c-Src promotes tumor progression via donwregulation of miR-129-1-3p

Okuzaki D, Yamauchi T, Mitani F, Miyata M, Ninomiya Y, Watanabe R, Akamatsu H, Oneyama C

Cancer Science　Vol. in press　2019年12月　研究論文（学術雑誌）

Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen's disease

Tomo Kamitani, Hiroyuki Murota, Noriko Arase, Mari Wataya-Kaneda, Ryoko Sato-Nishiuchi, Kiyotoshi Sekiguchi, Daisuke Okuzaki, Daisuke Motooka, Ichiro Katayama

Journal of Dermatological Science　Vol. 96　No. 2　p. 73-80　2019年11月　研究論文（学術雑誌）

E-cadherin-Fc chimera protein matrix enhances cancer stem-like properties and induces mesenchymal features in colon cancer cells

Yamin Qian, Xin Wu, Yuhki Yokoyama, Daisuke Okuzaki, Mai Taguchi, Haruka Hirose, Jiaqi Wang, Tsuyoshi Hata, Akira Inoue, Masayuki Hiraki, Masahisa Ohtsuka, Hidekazu Takahashi, Naotsugu Haraguchi, Tsunekazu Mizushima, Shinji Tanaka, Masaki Mori, Hirofumi Yamamoto

Cancer Science　Vol. 110　No. 11　p. 3520-3532　2019年11月1日　研究論文（学術雑誌）

CDCP1 controls compensatory renal growth by integrating Src and Met signaling

Kajiwara K, Aoki K, Okuzaki D, Matsumoto K, Okada M

bioRxiv　2019年10月

Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement.

Motoki Okamoto, Manahil Ali, Shungo Komichi, Masakatsu Watanabe, Hailing Huang, Yuki Ito, Jiro Miura, Yujiro Hirose, Manabu Mizuhira, Yusuke Takahashi, Daisuke Okuzaki, Shigetada Kawabata, Satoshi Imazato, Mikako Hayashi

Journal of clinical medicine　Vol. 8　No. 9　2019年9月11日　研究論文（学術雑誌）

Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection

Mayuko Osada-Oka, Nobuhito Goda, Hiroyuki Saiga, Masahiro Yamamoto, Kiyoshi Takeda, Yuriko Ozeki, Takehiro Yamaguchi, Tomoyoshi Soga, Yu Tateishi, Katsuyuki Miura, Daisuke Okuzaki, Kazuo Kobayashi, Sohkichi Matsumoto

International Immunology　Vol. 31　No. 12　p. 781-793　2019年8月1日　研究論文（学術雑誌）

Polydomはフォン・レックリングハウゼン病の皮膚型神経線維腫形成メカニズムに関与する

神谷 智, 室田 浩之, 荒瀬 規子, 金田 眞理, 佐藤 涼子, 関口 清俊, 奥崎 大介, 元岡 大祐, 片山 一朗

日本レックリングハウゼン病学会雑誌　Vol. 10　No. 1　p. 41-42　2019年7月

KLF5とTFDP1をターゲットとした大腸癌に対する新規核酸治療としてのmiR-4711-5p

森本祥悠, 高橋秀和, 呉しん, 奥崎大介, 横山雄起, 荻野崇之, 三吉範克, 植村守, 松田宙, 永島恒和, 森正樹, 土岐祐一郎, 山本浩文, 山本浩文

日本癌学会学術総会抄録集(Web)　Vol. 78th　p. E-1101　2019年

Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver

Ueda, T., Yokota, T., Okuzaki, D., Uno, Y., Mashimo, T., Kubota, Y., Sudo, T., Ishibashi, T., Shingai, Y., Doi, Y., Ozawa, T., Nakai, R., Tanimura, A., Ichii, M., Ezoe, S., Shibayama, H., Oritani, K., Kanakura, Y.

Stem Cell Reports　Vol. 13　No. 6　p. 992-1005　2019年　研究論文（学術雑誌）

Serum deprivation-response protein regulates aldehyde dehydrogenase 1 through integrin-linked kinase signaling in endometrioid carcinoma cells

Tahara, S., Nojima, S., Ohshima, K., Hori, Y., Kurashige, M., Wada, N., Motoyama, Y., Okuzaki, D., Ikeda, J.-I., Morii, E.

Cancer Science　Vol. 110　No. 5　p. 1804-1813　2019年　研究論文（学術雑誌）

Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1

Hasegawa, T., Kikuta, J., Sudo, T., Matsuura, Y., Matsui, T., Simmons, S., Ebina, K., Hirao, M., Okuzaki, D., Yoshida, Y., Hirao, A., Kalinichenko, V.V., Yamaoka, K., Takeuchi, T., Ishii, M.

Nature Immunology　Vol. 20　No. 12　p. 1631-1643　2019年　研究論文（学術雑誌）

A new approach to identifying hypertension-associated genes in the mesenteric artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

Ikawa, T., Watanabe, Y., Okuzaki, D., Goto, N., Okamura, N., Yamanishi, K., Higashino, T., Yamanishi, H., Okamura, H., Higashino, H.

Journal of Hypertension　Vol. 37　No. 8　p. 1644-1656　2019年　研究論文（学術雑誌）

DMPK is a new candidate mediator of tumor suppressor p53-dependent cell death

Itoh, K., Ebata, T., Hirata, H., Torii, T., Sugimoto, W., Onodera, K., Nakajima, W., Uehara, I., Okuzaki, D., Yamauchi, S., Budirahardja, Y., Nishikata, T., Tanaka, N., Kawauchi, K.

Molecules　Vol. 24　No. 17　p. 3175-3175　2019年　研究論文（学術雑誌）

Distinct methylation levels of mature microRNAs in gastrointestinal cancers

Konno, M., Koseki, J., Asai, A., Yamagata, A., Shimamura, T., Motooka, D., Okuzaki, D., Kawamoto, K., Mizushima, T., Eguchi, H., Takiguchi, S., Satoh, T., Mimori, K., Ochiya, T., Doki, Y., Ofusa, K., Mori, M., Ishii, H.

Nature Communications　Vol. 10　No. 1　p. 3888-3888　2019年　研究論文（学術雑誌）

Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis

Hirose, Y., Yamaguchi, M., Okuzaki, D., Motooka, D., Hamamoto, H., Hanada, T., Sumitomo, T., Nakata, M., Kawabata, S.

Applied and Environmental Microbiology　Vol. 85　No. 21　2019年　研究論文（学術雑誌）

CXCR4 regulates Plasmodium development in mouse and human hepatocytes

Bando, H., Pradipta, A., Iwanaga, S., Okamoto, T., Okuzaki, D., Tanaka, S., Vega-Rodríguez, J., Lee, Y., Ma, J.S., Sakaguchi, N., Soga, A., Fukumoto, S., Sasai, M., Matsuura, Y., Yuda, M., Jacobs-Lorena, M., Yamamoto, M.

The Journal of experimental medicine　Vol. 216　No. 8　p. 1733-1748　2019年　研究論文（学術雑誌）

Characterization of human pegivirus infection in liver transplantation recipients

Izumi, T., Sakata, K., Okuzaki, D., Inokuchi, S., Tamura, T., Motooka, D., Nakamura, S., Ono, C., Shimokawa, M., Matsuura, Y., Mori, M., Fukuhara, T., Yoshizumi, T.

Journal of Medical Virology　Vol. 91　No. 12　p. 2093-2100　2019年　研究論文（学術雑誌）

Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling

Imai, R., Sato, T., Iwamoto, Y., Hanada, Y., Terao, M., Ohta, Y., Osaki, Y., Imai, T., Morihana, T., Okazaki, S., Oshima, K., Okuzaki, D., Katayama, I., Inohara, H.

JARO - Journal of the Association for Research in Otolaryngology　Vol. 20　No. 5　p. 449-459　2019年　研究論文（学術雑誌）

Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

Nawa, N., Hirata, K., Kawatani, K., Nambara, T., Omori, S., Banno, K., Kokubu, C., Takeda, J., Nishimura, K., Ohtaka, M., Nakanishi, M., Okuzaki, D., Taniguchi, H., Arahori, H., Wada, K., Kitabatake, Y., Ozono, K.

PLoS ONE　Vol. 14　No. 7　2019年　研究論文（学術雑誌）

Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP1

Tsai CY, Sakakibara S, Yasui T, Minamitani T, Okuzaki D, Kikutani H

International Immunology　Vol. 30　No. 12　p. 579-590　2018年12月　研究論文（学術雑誌）

A convolutional neural network uses microscopic images to differentiate between mouse and human cell lines and their radioresistant clones

Masayasu Toratani, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Keisuke Tamari, Zhihao Li, Daisuke Sakai, Toshihiro Kudo, Taroh Satoh, Katsutoshi Sato, Daisuke Motooka, Daisuke Okuzaki, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

Cancer Research　Vol. 78　No. 23　p. 6703-6707　2018年12月1日　研究論文（学術雑誌）

Next Generation Sequencing Reveals Intra-Cardiac/Extra-Cardiac Circulating MicroRNA Transcriptomes in Atrial Fibrillation

Masahide Harada, Daisuke Okuzaki, Jun Takeda, Yuji Motoike, Masayuki Koshikawa, Eiichi Watanabe, Yukio Ozaki

CIRCULATION　Vol. 138　2018年11月

Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients

Akio Osa, Takeshi Uenami, Shohei Koyama, Kosuke Fujimoto, Daisuke Okuzaki, Takayuki Takimoto, Haruhiko Hirata, Yukihiro Yano, Soichiro Yokota, Yuhei Kinehara, Yujiro Naito, Tomoyuki Otsuka, Masaki Kanazu, Muneyoshi Kuroyama, Masanari Hamaguchi, Taro Koba, Yu Futami, Mikako Ishijima, Yasuhiko Suga, Yuki Akazawa, Hirotomo Machiyama, Kota Iwahori, Hyota Takamatsu, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida, Esra A. Akbay, Peter S. Hammerman, Kwok Kin Wong, Glenn Dranoff, Masahide Mori, Takashi Kijima, Atsushi Kumanogoh

JCI insight　Vol. 3　No. 19　2018年10月4日　研究論文（学術雑誌）

A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells.

Inoue A, Mizushima T, Wu X, Okuzaki D, Kambara N, Ishikawa S, Wang J, Qian Y, Hirose H, Yokoyama Y, Ikeshima R, Hiraki M, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Yamamoto H

Vol. 17　No. 5　p. 977-987　2018年5月　研究論文（学術雑誌）

A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells.

Inoue A, Mizushima T, Wu X, Okuzaki D, Kambara N, Ishikawa S, Wang J, Qian Y, Hirose H, Yokoyama Y, Ikeshima R, Hiraki M, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Yamamoto H

Molecular cancer therapeutics　Vol. 17　No. 5　p. 977-987　2018年5月　研究論文（学術雑誌）

Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

Yamanishi, K., Maeda, S., Kuwahara-Otani, S., Hashimoto, T., Ikubo, K., Mukai, K., Nakasho, K., Gamachi, N., El-Darawish, Y., Li, W., Okuzaki, D., Watanabe, Y., Yamanishi, H., Okamura, H., Matsunaga, H.

Journal of translational medicine　Vol. 16　No. 1　p. 314-314　2018年　研究論文（学術雑誌）

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides

Nakata, J., Nakajima, H., Hayashibara, H., Imafuku, K., Morimoto, S., Fujiki, F., Motooka, D., Okuzaki, D., Hasegawa, K., Hosen, N., Tsuboi, A., Oka, Y., Kumanogoh, A., Oji, Y., Sugiyama, H.

Oncotarget　Vol. 9　No. 89　p. 36029-36038　2018年　研究論文（学術雑誌）

Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5

Yabuta, N., Ota, C., Sasakura, T., Naito, Y., Okuzaki, D., Fukushima, K., Nojima, H.

Scientific Reports　Vol. 8　No. 1　p. 4892-4892　2018年　研究論文（学術雑誌）

Physiological and molecular effects of interleukin-18 administration on the mouse kidney

Yamanishi, K., Mukai, K., Hashimoto, T., Ikubo, K., Nakasho, K., El-Darawish, Y., Li, W., Okuzaki, D., Watanabe, Y., Hayakawa, T., Nojima, H., Yamanishi, H., Okamura, H., Matsunaga, H.

Journal of Translational Medicine　Vol. 16　No. 1　p. 51-51　2018年　研究論文（学術雑誌）

Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity

Tsuda, T., Maeda, Y., Nishide, M., Koyama, S., Hayama, Y., Nojima, S., Takamatsu, H., Okuzaki, D., Kinehara, Y., Kato, Y., Nakatani, T., Obata, S., Akazawa, H., Shikina, T., Takeda, K., Hayama, M., Inohara, H., Kumanogoh, A.

International Immunology　Vol. 31　No. 1　p. 33-40　2018年　研究論文（学術雑誌）

The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis

Fukata, T., Mizushima, T., Nishimura, J., Okuzaki, D., Wu, X., Hirose, H., Yokoyama, Y., Kubota, Y., Nagata, K., Tsujimura, N., Inoue, A., Miyoshi, N., Haraguchi, N., Takahashi, H., Hata, T., Matsuda, C., Kayama, H., Takeda, K., Doki, Y., Mori, M., Yamamoto, H.

Molecular Therapy - Nucleic Acids　Vol. 12　p. 658-671　2018年　研究論文（学術雑誌）

In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption

Matsuura, Y., Kikuta, J., Kishi, Y., Hasegawa, T., Okuzaki, D., Hirano, T., Minoshima, M., Kikuchi, K., Kumanogoh, A., Ishii, M.

Annals of the Rheumatic Diseases　Vol. 77　No. 8　p. 1220-1226　2018年　研究論文（学術雑誌）

Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP1

Tsai, C.-Y., Sakakibara, S., Yasui, T., Minamitani, T., Okuzaki, D., Kikutani, H.

International immunology　Vol. 30　No. 12　p. 579-590　2018年　研究論文（学術雑誌）

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Kayama, H., Kohyama, M., Okuzaki, D., Motooka, D., Barman, S., Okumura, R., Muneta, M., Hoshino, K., Sasaki, I., Ise, W., Matsuno, H., Nishimura, J., Kurosaki, T., Nakamura, S., Arase, H., Kaisho, T., Takeda, K.

Proceedings of the National Academy of Sciences of the United States of America　Vol. 115　No. 33　p. 8418-8423　2018年　研究論文（学術雑誌）

MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression

Kokuda, R., Watanabe, R., Okuzaki, D., Akamatsu, H., Oneyama, C.

Genes to Cells　Vol. 23　No. 8　p. 688-701　2018年　研究論文（学術雑誌）

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization

Kang, S., Nakanishi, Y., Kioi, Y., Okuzaki, D., Kimura, T., Takamatsu, H., Koyama, S., Nojima, S., Nishide, M., Hayama, Y., Kinehara, Y., Kato, Y., Nakatani, T., Shimogori, T., Takagi, J., Toyofuku, T., Kumanogoh, A.

Nature Immunology　Vol. 19　No. 6　p. 561-570　2018年　研究論文（学術雑誌）

Variable SATB1 Levels Regulate Hematopoietic Stem Cell Heterogeneity with Distinct Lineage Fate

Doi, Y., Yokota, T., Satoh, Y., Okuzaki, D., Tokunaga, M., Ishibashi, T., Sudo, T., Ueda, T., Shingai, Y., Ichii, M., Tanimura, A., Ezoe, S., Shibayama, H., Kohwi-Shigematsu, T., Takeda, J., Oritani, K., Kanakura, Y.

Cell Reports　Vol. 23　No. 11　p. 3223-3235　2018年　研究論文（学術雑誌）

Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate

Park, H., Ohshima, K., Nojima, S., Tahara, S., Kurashige, M., Hori, Y., Okuzaki, D., Wada, N., Ikeda, J.-I., Morii, E.

Laboratory Investigation　Vol. 98　No. 4　p. 449-461　2018年　研究論文（学術雑誌）

Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease

Takeharu Minamitani, Yijie Ma, Hufeng Zhou, Hiroshi Kida, Chao Yuan Tsai, Masanori Obana, Daisuke Okuzaki, Yasushi Fujio, Atsushi Kumanogoh, Bo Zhao, Hitoshi Kikutani, Elliott Kieff, Benjamin E. Gewurz, Teruhito Yasui

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 18　p. 4751-4756　2017年5月2日　研究論文（学術雑誌）

Mouse model of Epstein–Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease

Takeharu Minamitani, Yijie Ma, Hufeng Zhou, Hiroshi Kida, Chao-Yuan Tsai, Masanori Obana, Daisuke Okuzaki, Yasushi Fujio, Atsushi Kumanogoh, Bo Zhao, Hitoshi Kikutani, Elliott Kieff, Benjamin E. Gewurz, Teruhito Yasui

Proceedings of the National Academy of Sciences of the United States of America　Vol. 114　No. 18　p. 4751-4756　2017年5月　研究論文（学術雑誌）

JMJD5 regulates HBV replication through interaction with HBx

Toru Okamoto, Kazuo Yamashita, Tatsuya Suzuki, Shinji Kusakabe, Junki Hirano, Takasuke Fukuhara, Atsuya Yamashita, Kazunobu Saito, Daisue Okuzaki, Daron M Stanley, Khoji Moriishi, Yoshiharu Matsuura

2017年4月　研究論文（国際会議プロシーディングス）

Erratum: Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

Kimura, T., Nada, S., Takegahara, N., Okuno, T., Nojima, S., Kang, S., Ito, D., Morimoto, K., Hosokawa, T., Hayama, Y., Mitsui, Y., Sakurai, N., Sarashina-Kida, H., Nishide, M., Maeda, Y., Takamatsu, H., Okuzaki, D., Yamada, M., Okada, M., Kumanogoh, A.

Nature communications　Vol. 8　p. 14711-14711　2017年　研究論文（学術雑誌）

Modest static pressure suppresses columnar epithelial cell growth in association with cell shape and cytoskeletal Modifications

Hagiyama, M., Yabuta, N., Okuzaki, D., Inoue, T., Takashima, Y., Kimura, R., Ri, A., Ito, A.

Frontiers in Physiology　Vol. 8　No. DEC　p. 997-997　2017年　研究論文（学術雑誌）

FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease

Okuzaki, D., Ota, K., Takatsuki, S.-I., Akiyoshi, Y., Naoi, K., Yabuta, N., Saji, T., Nojima, H.

Scientific Reports　Vol. 7　No. 1　p. 11334-11334　2017年　研究論文（学術雑誌）

Lamtor1 is critically required for CD4⁺ T cell proliferation and regulatory T Cell suppressive function

Hosokawa, T., Kimura, T., Nada, S., Okuno, T., Ito, D., Kang, S., Nojima, S., Yamashita, K., Nakatani, T., Hayama, Y., Kato, Y., Kinehara, Y., Nishide, M., Mikami, N., Koyama, S., Takamatsu, H., Okuzaki, D., Ohkura, N., Sakaguchi, S., Okada, M., Kumanogoh, A.

Journal of Immunology　Vol. 199　No. 6　p. 2008-2019　2017年　研究論文（学術雑誌）

BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection

Kitada, S., Kayama, H., Okuzaki, D., Koga, R., Kobayashi, M., Arima, Y., Kumanogoh, A., Murakami, M., Ikawa, M., Takeda, K.

Journal of Experimental Medicine　Vol. 214　No. 5　p. 1313-1331　2017年　研究論文（学術雑誌）

Characterization of miR-122-independent propagation of HCV

Ono, C., Fukuhara, T., Motooka, D., Nakamura, S., Okuzaki, D., Yamamoto, S., Tamura, T., Mori, H., Sato, A., Uemura, K., Fauzyah, Y., Kurihara, T., Suda, T., Nishio, A., Hmwe, S.S., Okamoto, T., Tatsumi, T., Takehara, T., Chayama, K., Wakita, T., Koike, K., Matsuura, Y.

PLoS Pathogens　Vol. 13　No. 5　2017年　研究論文（学術雑誌）

Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer

Ohshima, K., Nojima, S., Tahara, S., Kurashige, M., Hori, Y., Hagiwara, K., Okuzaki, D., Oki, S., Wada, N., Ikeda, J.-I., Kanai, Y., Morii, E.

Scientific Reports　Vol. 7　p. 45504-45504　2017年　研究論文（学術雑誌）

Regulation of intestinal homeostasis by the ulcerative colitis-Associated gene RNF186

Fujimoto, K., Kinoshita, M., Tanaka, H., Okuzaki, D., Shimada, Y., Kayama, H., Okumura, R., Furuta, Y., Narazaki, M., Tamura, A., Hatakeyama, S., Ikawa, M., Tsuchiya, K., Watanabe, M., Kumanogoh, A., Tsukita, S., Takeda, K.

Mucosal Immunology　Vol. 10　No. 2　p. 446-459　2017年　研究論文（学術雑誌）

CD14⁺ monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C

Nishio, A., Tatsumi, T., Nawa, T., Suda, T., Yoshioka, T., Onishi, Y., Aono, S., Shigekawa, M., Hikita, H., Sakamori, R., Okuzaki, D., Fukuhara, T., Matsuura, Y., Hiramatsu, N., Takehara, T.

Hepatology　Vol. 65　No. 1　p. 18-31　2017年　研究論文（学術雑誌）

Identification of a human intestinal myeloid cell subset that regulates gut homeostasis.

Barman S, Kayama H, Okuzaki D, Ogino T, Osawa H, Matsuno H, Mizushima T, Mori M, Nishimura J, Takeda K

International Immunology　Vol. 28　No. 11　p. 533-545　2016年11月　研究論文（学術雑誌）

Poster Abstract: Significance of CXCL12-CXCR7 Signaling for CD20(-)CD138(-) Subpopulation in Lymphoplasmacytic Lymphoma. Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016

Wada N, Ikeda J, Nojima S, Tahara S, Ohshima K, Okuzaki D, Morii E

The Journal of Pathology　Vol. 240　No. S1　p. S44-S44　2016年10月　研究論文（国際会議プロシーディングス）

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K

Mucosal Immunol.　2016年7月　研究論文（学術雑誌）

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K

Mucosal Immunol.　2016年7月　研究論文（学術雑誌）

Transcriptional profile during deoxycholate-induced sporulation in a Clostridium perfringens isolate causing foodborne illness

Mayo Yasugi, Daisuke Okuzaki, Ritsuko Kuwana, Hiromu Takamatsu, Masaya Fujita, Mahfuzur R. Sarker, Masami Miyake

Applied and Environmental Microbiology　Vol. 82　No. 10　p. 2929-2942　2016年5月1日　研究論文（学術雑誌）

Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2

Makoto Fujiwara, Takuo Kubota, Wei Wang, Yasuhisa Ohata, Kohji Miura, Taichi Kitaoka, Daisuke Okuzaki, Noriyuki Namba, Toshimi Michigami, Yasuji Kitabatake, Keiichi Ozono

Bone　Vol. 85　p. 91-98　2016年4月　研究論文（学術雑誌）

Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2

Ohno, S., Ikeda, J.-I., Naito, Y., Okuzaki, D., Sasakura, T., Fukushima, K., Nishikawa, Y., Ota, K., Kato, Y., Wang, M., Torigata, K., Kasama, T., Uchihashi, T., Miura, D., Yabuta, N., Morii, E., Nojima, H.

Scientific reports　Vol. 6　No. 1　p. 39091-39091　2016年　研究論文（学術雑誌）

Down-Regulation of microRNA-132 is Associated with Poor Prognosis of Colorectal Cancer

Mokutani, Y., Uemura, M., Munakata, K., Okuzaki, D., Haraguchi, N., Takahashi, H., Nishimura, J., Hata, T., Murata, K., Takemasa, I., Mizushima, T., Doki, Y., Mori, M., Yamamoto, H.

Annals of Surgical Oncology　Vol. 23　No. Suppl 5　p. 599-608　2016年　研究論文（学術雑誌）

GAKがリン酸化したTAp63はLCE1C遺伝子を特異的に転写誘導する。

太田知絵, 篠倉悠久, 奥崎大介, 福島孝士朗, 向井智美, 藪田紀一, 野島博

日本分子生物学会年会プログラム・要旨集(Web)　Vol. 39th　2016年

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

Kimura, T., Nada, S., Takegahara, N., Okuno, T., Nojima, S., Kang, S., Ito, D., Morimoto, K., Hosokawa, T., Hayama, Y., Mitsui, Y., Sakurai, N., Sarashina-Kida, H., Nishide, M., Maeda, Y., Takamatsu, H., Okuzaki, D., Yamada, M., Okada, M., Kumanogoh, A.

Nature Communications　Vol. 7　p. 13130-13130　2016年　研究論文（学術雑誌）

Identification of a human intestinal myeloid cell subset that regulates gut homeostasis

Barman, S., Kayama, H., Okuzaki, D., Ogino, T., Osawa, H., Matsuno, H., Mizushima, T., Mori, M., Nishimura, J., Takeda, K.

International Immunology　Vol. 28　No. 11　p. 533-545　2016年　研究論文（学術雑誌）

Interleukin-18–deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis

Yamanishi, K., Maeda, S., Kuwahara-Otani, S., Watanabe, Y., Yoshida, M., Ikubo, K., Okuzaki, D., El-Darawish, Y., Li, W., Nakasho, K., Nojima, H., Yamanishi, H., Hayakawa, T., Okamura, H., Matsunaga, H.

Translational Research　Vol. 173　p. 101-114.e7　2016年　研究論文（学術雑誌）

LATS2 positively regulates polycomb repressive complex 2

Torigata, K., Daisuke, O., Mukai, S., Hatanaka, A., Ohka, F., Motooka, D., Nakamura, S., Ohkawa, Y., Yabuta, N., Kondo, Y., Nojima, H.

PLoS ONE　Vol. 11　No. 7　2016年　研究論文（学術雑誌）

Requirement of CXCL12-CXCR7 signaling for CD20 - CD138 - double-negative population in lymphoplasmacytic lymphoma

Wada, N., Ikeda, J.-I., Nojima, S., Tahara, S.-I., Ohshima, K., Okuzaki, D., Morii, E.

Laboratory Investigation　Vol. 96　No. 5　p. 517-525　2016年　研究論文（学術雑誌）

Endothelial cell-selective adhesion molecule expression in hematopoietic stem/progenitor cells is essential for erythropoiesis recovery after bone marrow injury

Sudo, T., Yokota, T., Okuzaki, D., Ueda, T., Ichii, M., Ishibashi, T., Isono, T., Habuchi, Y., Oritani, K., Kanakura, Y.

PLoS ONE　Vol. 11　No. 4　2016年　研究論文（学術雑誌）

IFI27 is a useful genetic marker for diagnosis of immunoglobulin A nephropathy and membranous nephropathy using peripheral blood

Nagasawa, Y., Okuzaki, D., Muso, E., Yamamoto, R., Shinzawa, M., Iwasaki, Y., Iwatani, H., Nakanishi, T., Isaka, Y., Nojima, H.

PLoS ONE　Vol. 11　No. 4　2016年　研究論文（学術雑誌）

Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2

Fujiwara, M., Kubota, T., Wang, W., Ohata, Y., Miura, K., Kitaoka, T., Okuzaki, D., Namba, N., Michigami, T., Kitabatake, Y., Ozono, K.

Bone　Vol. 85　p. 91-98　2016年　研究論文（学術雑誌）

Microarray and whole-exome sequencing analysis of familial Behçet's disease patients

Okuzaki D, Yoshizaki K, Tanaka T, Hirano T, Fukushima K, Washio T, Nojima H

Sci Rep.　Vol. 6　No. 6　p. 19456-19456　2016年　研究論文（学術雑誌）

Hepatocyte factor JMJD5 regulates hepatitis B virus replication through interaction with HBx

Takahisa Kouwaki, Toru Okamoto, Ayano Ito, Yukari Sugiyama, Kazuo Yamashita, Tatsuya Suzuki, Shinji Kusakabe, Junki Hirano, Takasuke Fukuhara, Atsuya Yamashita, Kazunobu Saito, Daisuke Okuzaki, Koichi Watashi, Masaya Sugiyama, Sachiyo Yoshio, Daron M. Standley, Tatsuya Kanto, Masashi Mizokami, Kohji Moriishi, Yoshiharu Matsuura

Journal of Virology　Vol. 90　No. 7　p. 3530-3542　2016年　研究論文（学術雑誌）

MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling

Matsuyama, R., Okuzaki, D., Okada, M., Oneyama, C.

Cancer Science　Vol. 107　No. 1　p. 28-35　2016年　研究論文（学術雑誌）

Influenza a virus-induced expression of a galnac transferase, GALNT3, via micrornas is required for enhanced viral replication

Shoko Nakamura, Masayuki Horie, Tomo Daidoji, Tomoyuki Honda, Mayo Yasugi, Atsushi Kuno, Toshihisa Komori, Daisuke Okuzaki, Hisashi Narimatsu, Takaaki Nakaya, Keizo Tomonaga

Journal of Virology　Vol. 90　No. 4　p. 1788-1801　2016年　研究論文（学術雑誌）

LATS2 Positively Regulates Polycomb Repressive Complex 2.

Torigata K, Daisuke O, Mukai S, Hatanaka A, Ohka F, Motooka D, Nakamura S, Ohkawa Y, Yabuta N, Kondo Y, Nojima H

PLoS ONE　Vol. 11　No. 7　2016年　研究論文（学術雑誌）

Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A

Takeharu Minamitani, Teruhito Yasui, Yijie Ma, Hufeng Zhou, Daisuke Okuzaki, Chiau Yuang Tsai, Shuhei Sakakibara, Benjamin E. Gewurz, Elliott Kieff, Hitoshi Kikutani

Proceedings of the National Academy of Sciences of the United States of America　Vol. 112　No. 37　p. 11612-11617　2015年9月15日　研究論文（学術雑誌）

Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy

Takafumi Yokota, Kenji Oritani, Takao Sudo, Tomohiko Ishibashi, Yukiko Doi, Yoko Habuchi, Michiko Ichii, Kentaro Fukushima, Daisuke Okuzaki, Kazuma Tomizuka, Kengo Yamawaki, Makoto Kakitani, Akihiko Shimono, Eiichi Morii, Paul W. Kincade, Yuzuru Kanakura

European Journal of Immunology　Vol. 45　No. 5　p. 1390-1401　2015年5月1日　研究論文（学術雑誌）

Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer

Nonaka, R., Miyake, Y., Hata, T., Kagawa, Y., Kato, T., Osawa, H., Nishimura, J., Ikenaga, M., Murata, K., Uemura, M., Okuzaki, D., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M.

International Journal of Oncology　Vol. 47　No. 3　p. 1097-1102　2015年　研究論文（学術雑誌）

Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys

Watanabe, Y., Yoshida, M., Yamanishi, K., Yamamoto, H., Okuzaki, D., Nojima, H., Yasunaga, T., Okamura, H., Matsunaga, H., Yamanishi, H.

International Journal of Molecular Medicine　Vol. 36　No. 3　p. 712-724　2015年　研究論文（学術雑誌）

γ-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.

Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D, Yamamoto A, Tani K, Tagaya M

J Cell Sci　Vol. 128　No. 15　p. 2781-2794　2015年　研究論文（学術雑誌）

Withaferin A induces cell death selectively in androgen-independent prostate cancer cells but not in normal fibroblast cells

Nishikawa, Y., Okuzaki, D., Fukushima, K., Mukai, S., Ohno, S., Ozaki, Y., Yabuta, N., Nojima, H.

PLoS ONE　Vol. 10　No. 7　2015年　研究論文（学術雑誌）

Identification of non-coding RNAs associated with telomeres using a combination of enChIP and RNA sequencing

Fujita, T., Yuno, M., Okuzaki, D., Ohki, R., Fujii, H.

PLoS ONE　Vol. 10　No. 4　2015年　研究論文（学術雑誌）

RFPL4A increases the G<inf>1</inf> population and decreases sensitivity to chemotherapy in human colorectal cancer cells

Naito, A., Yamamoto, H., Kagawa, Y., Naito, Y., Okuzaki, D., Otani, K., Iwamoto, Y., Maeda, S., Kikuta, J., Nishikawa, K., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Ishii, H., Doki, Y., Mori, M., Ishii, M.

Journal of Biological Chemistry　Vol. 290　No. 10　p. 6326-6337　2015年　研究論文（学術雑誌）

Partial maintenance and long-term expansion of murine skin epithelial stem cells by wnt-3a in vitro

Ouji, Y., Ishizaka, S., Nakamura-Uchiyama, F., Okuzaki, D., Yoshikawa, M.

Journal of Investigative Dermatology　Vol. 135　No. 6　p. 1598-1608　2015年　研究論文（学術雑誌）

Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer

Ryoji Nonaka, Junichi Nishimura, Yoshinori Kagawa, Hideki Osawa, Junichi Hasegawa, Kohei Murata, Shu Okamura, Hirofumi Ota, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Daisuke Okuzaki, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

Oncology Reports　Vol. 32　No. 6　p. 2354-2358　2014年12月1日　研究論文（学術雑誌）

ウィザフェリンAはc-Fos誘導を介してスフェロイド形成能を持つ前立腺がん細胞の選択的な細胞死を引き起こす(Withaferin A selectively causes cell death in spheroid forming prostate cancer cells through induction of c-Fos)

福島 孝士朗, 奥崎 大介, 大野 将一, 野崎 正美, 藪田 紀一, 野島 博

日本癌学会総会記事　Vol. 73回　p. P-2405　2014年9月

ゲフィチニブとルテオリンの同時投与はヒト前立腺がん細胞株PC-3細胞の効果的な細胞死を誘導する(Co-administration of gefitinib and luteolin induced efficient cell death of human prostate cancer PC-3 cells)

篠倉 悠久, 奥崎 大介, 内藤 陽子, 藪田 紀一, 野島 博

日本癌学会総会記事　Vol. 73回　p. P-1388　2014年9月

Characterization of HCV propagation in miR-122 knockout cells

Chikako Ono, Takasuke Fukuhara, Satomi Yamamoto, Masami Wada, Toru Okamoto, Daisuke Okuzaki, Yoshiharu Matsuura

2014年9月　研究論文（国際会議プロシーディングス）

Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis

Natsuko Fujita, Kenji Oritani, Michiko Ichii, Takafumi Yokota, Norimitsu Saitoh, Daisuke Okuzaki, Yuichi Sekine, Shigeyuki Kon, Ryuta Muromoto, Kodai Saitoh, Akihiko Yoshimura, Tadashi Matsuda, Yuzuru Kanakura

European Journal of Immunology　Vol. 44　No. 6　p. 1791-1801　2014年6月　研究論文（学術雑誌）

Characterization of HCV Propagation in miR-122 Knockout Cells

Chikako Ono, Takasuke Fukuhara, Mai Shiokawa, Satomi Yamamoto, Masami Wada, Toru Okamoto, Daisuke Okuzaki, Yoshiharu Matsuura

2014年6月　研究論文（国際会議プロシーディングス）

エピゲノムの多様性・特異性を生み出す新規上流シグナルの探索

鳥形 康輔, 奥崎 大介, 畑中 彬良, 大岡 史治, 大川 恭行, 小根山 千歳, 近藤 豊, 藪田 紀一, 野島 博

2014年5月

Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.

Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y

PLoS pathogens　Vol. 10　No. 12　2014年　研究論文（学術雑誌）

ゴルジ装置の酸性環境と膜接触場を介した細胞内コレステロールの生合成・輸送の調節

前田裕輔, 前田裕輔, 木下タロウ, 木下タロウ, 奥崎大介

日本生化学会大会(Web)　Vol. 87th　p. [1S04-5]　2014年

Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630

Sakurai, M.A., Ozaki, Y., Okuzaki, D., Naito, Y., Sasakura, T., Okamoto, A., Tabara, H., Inoue, T., Hagiyama, M., Ito, A., Yabuta, N., Nojima, H.

PLoS ONE　Vol. 9　No. 6　2014年　研究論文（学術雑誌）

Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the brain

Yoshida, M., Watanabe, Y., Yamanishi, K., Yamashita, A., Yamamoto, H., Okuzaki, D., Shimada, K., Nojima, H., Yasunaga, T., Okamura, H., Matsunaga, H., Yamanishi, H.

International Journal of Molecular Medicine　Vol. 33　No. 4　p. 887-896　2014年　研究論文（学術雑誌）

Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo

Yoshinori Kagawa, Shinji Matsumoto, Yuji Kamioka, Koshi Mimori, Yoko Naito, Taeko Ishii, Daisuke Okuzaki, Naohiro Nishida, Sakae Maeda, Atsushi Naito, Junichi Kikuta, Keizo Nishikawa, Junichi Nishimura, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hirofumi Yamamoto, Mitsugu Sekimoto, Hideshi Ishii, Yuichiro Doki, Michiyuki Matsuda, Akira Kikuchi, Masaki Mori, Masaru Ishii

PLoS ONE　Vol. 8　No. 12　2013年12月30日　研究論文（学術雑誌）

Increased Th17-inducing activity of CD14⁺ CD163^low myeloid cells in intestinal lamina propria of patients with Crohn's disease

Takayuki Ogino, Junichi Nishimura, Soumik Barman, Hisako Kayama, Satoshi Uematsu, Daisuke Okuzaki, Hideki Osawa, Naotsugu Haraguchi, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori

Gastroenterology　Vol. 145　No. 6　p. 1380-91　2013年12月　研究論文（学術雑誌）

Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats

Yamamoto, H., Okuzaki, D., Yamanishi, K., Xu, Y., Watanabe, Y., Yoshida, M., Yamashita, A., Goto, N., Nishiguchi, S., Shimada, K., Nojima, H., Yasunaga, T., Okamura, H., Matsunaga, H., Yamanishi, H.

International Journal of Molecular Medicine　Vol. 31　No. 5　p. 1057-1065　2013年　研究論文（学術雑誌）

Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients

Muso, E., Okuzaki, D., Kobayashi, S., Iwasaki, Y., Sakurai, M.A., Ito, A., Nojima, H.

Autoimmunity　Vol. 46　No. 8　p. 513-524　2013年　研究論文（学術雑誌）

CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice.

Nagi-Miura N, Okuzaki D, Torigata K, Sakurai MA, Ito A, Ohno N, Nojima H

BMC immunology　Vol. 14　No. 1　p. 44-44　2013年　研究論文（学術雑誌）

MiR-424/503-Mediated rictor upregulation promotes tumor progression

Oneyama, C., Kito, Y., Asai, R., Ikeda, J.-I., Yoshida, T., Okuzaki, D., Kokuda, R., Kakumoto, K., Takayama, K.-I., Inoue, S., Morii, E., Okada, M.

PLoS ONE　Vol. 8　No. 11　2013年　研究論文（学術雑誌）

N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability

Norikazu Yabuta, Satomi Mukai, Ayumi Okamoto, Daisuke Okuzaki, Hirokazu Suzuki, Kosuke Torigata, Kaori Yoshida, Nobuhiro Okada, Daisaku Miura, Akihiko Ito, Masahito Ikawa, Masaru Okabe, Hiroshi Nojima

Journal of Cell Science　Vol. 126　No. 2　p. 508-519　2013年1月　研究論文（学術雑誌）

Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I

Katahira, J., Okuzaki, D., Inoue, H., Yoneda, Y., Maehara, K., Ohkawa, Y.

Nucleic Acids Research　Vol. 41　No. 14　p. 7060-7072　2013年　研究論文（学術雑誌）

miR-122遺伝子欠損Huh7細胞株におけるC型肝炎ウイルスの増殖

小野慎子, 福原崇介, 塩川舞, 山本聡美, 和田真実, 岡本徹, 奥崎大介, 松浦善治

日本ウイルス学会学術集会プログラム・抄録集　Vol. 61st　2013年

MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

C. Oneyama, E. Morii, D. Okuzaki, Y. Takahashi, J. Ikeda, N. Wakabayashi, H. Akamatsu, M. Tsujimoto, T. Nishida, K. Aozasa, M. Okada

Oncogene　Vol. 31　No. 13　p. 1623-1635　2012年3月29日　研究論文（学術雑誌）

Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus

Takasuke Fukuhara, Hiroto Kambara, Mai Shiokawa, Chikako Ono, Hiroshi Katoh, Eiji Morita, Daisuke Okuzaki, Yoshihiko Maehara, Kazuhiko Koike, Yoshiharu Matsuura

Journal of Virology　Vol. 86　No. 15　p. 7918-7933　2012年　研究論文（学術雑誌）

Ficolin 1 Expression is Elevated in the Peripheral Blood Mononuclear Cells of Takayasu’s Vasculitis Patients

Okuzaki D, Kobayashi S, Sakurai MA, Torigata K, Okamoto A, Matsumoto T, Daida H, Ito A, Nojima H

J Mol Biomark Diagn　Vol. 2　p. 125-125　2012年

LeukoCatch, a quick and efficient tool for the preparation of leukocyte extracts from blood

Okuzaki, D., Kimura, S., Yabuta, N., Ohmine, T., Nojima, H.

BMC Clinical Pathology　Vol. 11　p. 9-9　2011年　研究論文（学術雑誌）

Microarray analysis of tonsils of IgA nephropathy patients

Iwatani, H., Iio, K., Nagasawa, Y., Yamamoto, R., Horii, A., Okuzaki, D., Inohara, H., Nojima, H., Imai, E., Rakugi, H., Isaka, Y.

Advances in Oto-Rhino-Laryngology　Vol. 72　p. 75-78　2011年　研究論文（学術雑誌）

MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways

Oneyama, C., Ikeda, J., Okuzaki, D., Suzuki, K., Kanou, T., Shintani, Y., Morii, E., Okumura, M., Aozasa, K., Okada, M.

Oncogene　Vol. 30　No. 32　p. 3489-3501　2011年　研究論文（学術雑誌）

Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein

Honda, T., Fujino, K., Okuzaki, D., Ohtaki, N., Matsumoto, Y., Horie, M., Daito, T., Itoh, M., Tomonaga, K.

Journal of Virology　Vol. 85　No. 9　p. 4567-4571　2011年　研究論文（学術雑誌）

The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe

Takahiro Tougan, Takashi Kasama, Ayami Ohtaka, Daisuke Okuzaki, Takamune T. Saito, Paul Russell, Hiroshi Nojima

Cell Cycle　Vol. 9　No. 23　p. 4688-4702　2010年12月1日　研究論文（学術雑誌）

Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe

Daisuke Okuzaki, Takashi Kasama, Aiko Hirata, Ayami Ohtaka, Reiko Kakegawa, Hiroshi Nojima

Cell Cycle　Vol. 9　No. 18　p. 3775-3784　2010年9月15日　研究論文（学術雑誌）

Genopal™: A novel hollow fibre array for focused microarray analysis

Okuzaki, D., Fukushima, T., Tougan, T., Ishii, T., Kobayashi, S., Yoshizaki, K., Akita, T., Nojima, H.

DNA Research　Vol. 17　No. 6　p. 369-379　2010年　研究論文（学術雑誌）

Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.

Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H

Curr Biol.　Vol. 20　No. 21　p. 1945-1952　2010年　研究論文（学術雑誌）

Mug28, a meiosis-specific protein of Schizosaccharomyces pombe, regulates spore wall formation

Shigehisa, A., Okuzaki, D., Kasama, T., Tohda, H., Hirata, A., Nojima, H.

Molecular Biology of the Cell　Vol. 21　No. 12　p. 1955-1967　2010年　研究論文（学術雑誌）

Microarray analysis of tonsils in immunoglobulin A nephropathy patients

Iio, K., Nagasawa, Y., Iwatani, H., Yamamoto, R., Horii, A., Okuzaki, D., Furumatsu, Y., Inohara, H., Nojima, H., Imai, E., Isaka, Y., Rakugi, H.

Biochemical and Biophysical Research Communications　Vol. 393　No. 4　p. 565-570　2010年　研究論文（学術雑誌）

Chum-RNA allows preparation of a high-quality cDNA library from a single-cell quantity of mRNA without PCR amplification.

Tougan T, Okuzaki D, Nojima H

Nucleic Acids Research　Vol. 36　No. 15　2008年9月　研究論文（学術雑誌）

Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients.

Kobayashi S, Ito A, Okuzaki D, Onda H, Yabuta N, Nagamori I, Suzuki K, Hashimoto H, Nojima H

DNA Research　Vol. 15　No. 4　p. 253-265　2008年8月　研究論文（学術雑誌）

Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation.

Ohtaka A, Okuzaki D, Nojima H

Journal of cell science　Vol. 121　No. Pt 9　p. 1547-58　2008年5月　研究論文（学術雑誌）

Focused microarray analysis of peripheral mononuclear blood cells from Churg-Strauss syndrome patients.

Tougan T, Onda H, Okuzaki D, Kobayashi S, Hashimoto H, Nojima H

DNA Research　Vol. 15　No. 2　p. 103-114　2008年4月　研究論文（学術雑誌）

Lats2 is an essential mitotic regulator required for the coordination of cell division

Norikazu Yabuta, Nobuhiro Okada, Akihiko Ito, Toshiya Hosomi, Souichi Nishihara, Yuya Sasayama, Azumi Fujimori, Daisuke Okuzaki, Hanjun Zhao, Masahito Ikawa, Masaru Okabe, Hiroshi Nojima

Journal of Biological Chemistry　Vol. 282　No. 26　p. 19259-19271　2007年6月29日　研究論文（学術雑誌）

Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe.

Ohtaka A, Saito TT, Okuzaki D, Nojima H

Cell division　Vol. 2　p. 14-14　2007年　研究論文（学術雑誌）

Mcp4, a meiotic coiled-coil protein, plays a role in F-actin positioning during Schizosaccharomyces pombe meiosis

Ohtaka, A., Okuzaki, D., Saito, T.T., Nojima, H.

Eukaryotic Cell　Vol. 6　No. 6　p. 971-83　2007年　研究論文（学術雑誌）

Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients

Nobuo Nakamura, Yasunori Shimaoka, Takahiro Tougan, Hiroaki Onda, Daisuke Okuzaki, Hanjun Zhao, Azumi Fujimori, Norikazu Yabuta, Ippei Nagamori, Akie Tanigawa, Jun Sato, Takenori Oda, Kenji Hayashida, Ryuji Suzuki, Masao Yukioka, Hiroshi Nojima, Takahiro Ochi

DNA Research　Vol. 13　No. 4　p. 169-183　2006年8月　研究論文（学術雑誌）

Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast.

Saito TT, Okuzaki D, Nojima H

J Cell Biol.　2006年8月　研究論文（学術雑誌）

Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci

Takashi Kasama, Akira Shigehisa, Aiko Hirata, Takamune T. Saito, Takahiro Tougan, Daisuke Okuzaki, Hiroshi Nojima

Eukaryotic Cell　Vol. 5　No. 8　p. 1301-1313　2006年8月　研究論文（学術雑誌）

Mcp6, a meiosis-specific coiled-coil protein of Schizosaccharomyces pombe, localizes to the spindle pole body and is required for horsetail movement and recombination.

Saito TT, Tougan T, Okuzaki D, Kasama T, Nojima H

J Cell Sci.　2005年1月　研究論文（学術雑誌）

Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination.

Saito TT, Tougan T, Kasama T, Okuzaki D, Nojima H

Nucleic Acids Research　Vol. 32　No. 11　p. 3325-3339　2004年　研究論文（学術雑誌）

The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions

Okuzakil, D., Watanabe, T., Tanaka, S., Nojima, H.

Genes and Genetic Systems　Vol. 78　No. 2　p. 113-26　2003年　研究論文（学術雑誌）

Fission yeast meu14⁺ is required for proper nuclear division and accurate forespore membrane formation during meiosis II

Okuzaki, D., Satake, W., Hirata, A., Nojima, H.

Journal of Cell Science　Vol. 116　No. 13　p. 2721-2735　2003年　研究論文（学術雑誌）

Kcc4 associates with septin proteins of Saccharomyces cerevisiae

Daisuke Okuzaki, Hiroshi Nojima

FEBS Letters　Vol. 489　No. 2-3　p. 197-201　2001年2月2日　研究論文（学術雑誌）

Rad24 is essential for proliferation of diploid cells in fission yeast

Yoshimi Tanaka, Daisuke Okuzaki, Norikazu Yabuta, Takahiro Yoneki, Hiroshi Nojima

FEBS Letters　Vol. 472　No. 2-3　p. 254-258　2000年4月　研究論文（学術雑誌）

Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints

Midori Shimada, Daisuke Okuzaki, Seiji Tanaka, Takahiro Tougan, Katsuyuki K. Tamai, Chikashi Shimoda, Hiroshi Nojima

Molecular Biology of the Cell　Vol. 10　No. 12　p. 3991-4003　1999年12月　研究論文（学術雑誌）

Gin4 of 5. cerevisiae is a bud neck protein that interacts with the Cdc28 complex

Daisuke Okuzaki, Seiji Tanaka, Hiroshi Kanazawa, Hiroshi Nojima

Genes to Cells　Vol. 2　No. 12　p. 753-770　1997年　研究論文（学術雑誌）