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Kashiwagi Hirokazu

柏木 浩和

Osaka University Hospital, Associate Professor

Education

  • - 1986/03, Osaka University, Faculty of Medicine

Research History

  • 2012/04/01 - Present, Osaka University Graduate School of Medicine Division of Medicine, Associate Professor
  • 2010/10/01 - 2012/03/31, Osaka University Graduate School of Medicine Division of Medicine, Assistant Professor
  • 2007/04/01 - 2010/09/30, Osaka University Division of Internal Medicine, Assistant Professor
  • 2006/04/01 - 2007/03/31, Osaka University Division of Internal Medicine, Research Assistant

Research Areas

  • Life sciences, Hematology and oncology

Professional Memberships

  • 日本輸血・細胞治療学会
  • 日本血栓止血学会
  • 日本血液学会
  • 日本内科学会

Papers

  • Reevaluation of platelet function in chronic immune thrombocytopenia: impacts of platelet size, platelet-associated anti-αIIbβ3 antibodies and thrombopoietin receptor agonists., Nobuko Nishiura,Hirokazu Kashiwagi,Keigo Akuta,Satoru Hayashi,Hisashi Kato,Yuzuru Kanakura,Yoshiaki Tomiyama, British journal of haematology, Vol. 189, No. 4, p. 760-771, 2020/05
  • Risk factors for skin, mucosal, and organ bleeding in adults with primary ITP: a nationwide study in Japan., Takaaki Hato,Naoki Shimada,Yoshiyuki Kurata,Masataka Kuwana,Kingo Fujimura,Hirokazu Kashiwagi,Toshiro Takafuta,Mitsuru Murata,Yoshiaki Tomiyama, Blood advances, Vol. 4, No. 8, p. 1648-1655, 2020/04/28
  • Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision., Hirokazu Kashiwagi,Masataka Kuwana,Takaaki Hato,Toshiro Takafuta,Kingo Fujimura,Yoshiyuki Kurata,Mitsuru Murata,Yoshiaki Tomiyama, International journal of hematology, Vol. 111, No. 3, p. 329-351, 2020/03
  • Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction., Keigo Akuta,Kazunobu Kiyomizu,Hirokazu Kashiwagi,Shinji Kunishima,Nobuko Nishiura,Fumiaki Banno,Koichi Kokame,Hisashi Kato,Yuzuru Kanakura,Toshiyuki Miyata,Yoshiaki Tomiyama, Journal of thrombosis and haemostasis : JTH, Vol. 18, No. 2, p. 497-509, 2020/02
  • Secondary immune thrombocytopenic purpura with renal cell carcinoma., Shigeaki Nakazawa,Masataka Kawamura,Kosuke Nakano,Norichika Ueda,Hidefumi Kishikawa,Hirokazu Kashiwagi,Motohide Uemura,Ryoichi Imamura,Kenji Nishimura,Norio Nonomura, IJU case reports, Vol. 2, No. 5, p. 250-252, 2019/09
  • Additional validation of Osaka method (0.01 mol/L dithiothreitol) for negating the daratumumab interference., Hosokawa M,Kashiwagi H,Nakayama K,Sakuragi M,Nakao M,Morikawa T,Kiyokawa T,Aochi H,Nagamine K,Shibayama H,Tomiyama Y, Transfusion, Vol. 59, No. 7, p. 2479-2480, 2019/07
  • Reference guide for management of adult idiopathic thrombocytopenic purpura (ITP): 2019 version, KASHIWAGI Hirokazu, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 60, No. 8, p. 877-896, 2019
  • Distinct effects of daratumumab on indirect and direct antiglobulin tests: a new method employing 0.01 mol/L dithiothreitol for negating the daratumumab interference with preserving K antigenicity (Osaka method)., Hosokawa M,Kashiwagi H,Nakayama K,Sakuragi M,Nakao M,Morikawa T,Kiyokawa T,Aochi H,Nagamine K,Shibayama H,Tomiyama Y, Transfusion, Vol. 58, No. 12, p. 3003-3013, 2018/12
  • FCMを用いた血小板減少患者における血小板機能~凝集能を含めた検討~, 2018/06
  • からだの質問箱「23歳娘、本態性血小板血小板血症」., 2018/06
  • A unique phenotype of acquired Glanzmann thrombasthenia due to non function-blocking anti-αIIbβ3 autoantibodies., Akuta K,Kashiwagi H,Yujiri T,Nishiura N,Morikawa Y,Kato H,Honda S,Kanakura Y,Tomiyama Y, Journal of thrombosis and haemostasis : JTH, 2018/06
  • Daratumumabによる不規則抗体検査偽陽性への改良対処法-0.01M DTTを用いた検討, 2018/05
  • Immature platelet fraction (IPF) as a predictive value for thrombopoietic recovery after allogeneic stem cell transplantation, Mikiko Sakuragi,Satoru Hayashi,Miho Maruyama,Tomoko Kiyokawa,Keisuke Nagamine,Jiro Fujita,Tetsuo Maeda,Hisashi Kato,Hirokazu Kashiwagi,Yuzuru Kanakura,Yoshiaki Tomiyama, International Journal of Hematology, Springer Tokyo, Vol. 107, No. 3, p. 320-326, 2018/03/01
  • Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects, Yoichiro Morikawa,Hisashi Kato,Hirokazu Kashiwagi,Nobuko Nishiura,Keigo Akuta,Shigenori Honda,Yuzuru Kanakura,Yoshiaki Tomiyama, Thrombosis Research, Elsevier Ltd, Vol. 162, p. 44-52, 2018/02/01
  • 出血症状が出たときどうする?, 2017/08
  • 血小板機能と抗血小板薬, 2017/07
  • Diagnosis in General., 2017/06
  • ITP in Adults., 2017/06
  • 自己免疫性水疱症および橋本病に合併した後天性血友病A, 2017/03
  • Platelet Adhesive Protein Defect Disorders., 2017/03
  • Autoimmune bullous disease and Hashimoto's disease complicated by acquired hemophilia A., Nishiura N,Ujimoto D,Fujita J,Maeda T,Nakagawa Y,Kashiwagi H,Oritani K,Tomiyama Y,Kanakura Y, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 58, No. 3, p. 233-238, 2017
  • Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation., Kato H,Nakazawa Y,Kurokawa Y,Kashiwagi H,Morikawa Y,Morita D,Banno F,Honda S,Kanakura Y,Tomiyama Y, Blood, AMER SOC HEMATOLOGY, Vol. 128, No. 23, p. 2729-2733, 2016/12
  • Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti-Jr(a)., Fujita S,Kashiwagi H,Tomimatsu T,Ito S,Mimura K,Kanagawa T,Endo M,Miyoshi T,Okamura Y,Tani Y,Tomiyama Y,Kimura T, Transfusion, WILEY-BLACKWELL, Vol. 56, No. 5, p. 1171-1181, 2016/05
  • Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders, Mikiko Sakuragi,Satoru Hayashi,Miho Maruyama,Osamu Kabutomori,Tomoko Kiyokawa,Keisuke Nagamine,Hisashi Kato,Hirokazu Kashiwagi,Yuzuru Kanakura,Yoshiaki Tomiyama, INTERNATIONAL JOURNAL OF HEMATOLOGY, SPRINGER JAPAN KK, Vol. 101, No. 4, p. 369-375, 2015/04
  • [Recent advances in pathophysiology and treatment of immune thrombocytopenia]., Kashiwagi H,Tomiyama Y, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 56, No. 2, p. 177-184, 2015/02
  • 特発性血小板減少性紫斑病(ITP)の治療, Vol. 55, p. 2087-2094, 2014/10
  • [Management of idiopathic thrombocytopenic purpura (primary immune thrombocytopenia, ITP)]., Kashiwagi H,Tomiyama Y, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 55, No. 10, p. 2087-2094, 2014/10
  • 妊娠合併特発性血小板減少性紫斑病診療の参照ガイド, Vol. 55, No. 8, p. 934-947, 2014/08
  • [Consensus report for the management of pregnancy with primary immune thrombocytopenia]., Miyakawa Y,Kashiwagi H,Takafuta T,Fujimura K,Kurata Y,Kobayashi T,Kimura T,Adachi T,Watanabe T,Imaizumi M,Takahashi Y,Matsubara K,Terui K,Kuwana M,Kanagawa T,Murata M,Tomiyama Y,Committee for clinical,practice guide of,primary immune,thrombocytopenia in pregnancy, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 55, No. 8, p. 934-947, 2014/08
  • 止血異常の診断のすすめかた-病歴聴取、診察、止血スクリーニング検査とその読みかたの重要性-, Vol. 31, No. 1, p. 14-22, 2014/01
  • Pathophysiology and management of primary immune thrombocytopenia, Hirokazu Kashiwagi,Yoshiaki Tomiyama, INTERNATIONAL JOURNAL OF HEMATOLOGY, SPRINGER JAPAN KK, Vol. 98, No. 1, p. 24-33, 2013/07
  • Demonstration of novel gain-of-function mutations of αIIbβ3: association with macrothrombocytopenia and glanzmann thrombasthenia-like phenotype., Kashiwagi H,Kunishima S,Kiyomizu K,Amano Y,Shimada H,Morishita M,Kanakura Y,Tomiyama Y, Molecular genetics & genomic medicine, Vol. 1, No. 2, p. 77-86, 2013/07
  • [Pathophysiology and diagnosis of primary immune thrombocytopenia]., Tomiyama Y,Kiyomizu K,Kashiwagi H, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 54, No. 4, p. 343-349, 2013/04
  • Agonist stimulation, talin-1, and kindlin-3 are crucial for alpha(IIb)beta(3) activation in a human megakaryoblastic cell line, CMK, Tsuyoshi Nakazawa,Seiji Tadokoro,Tsuyoshi Kamae,Kazunobu Kiyomizu,Hirokazu Kashiwagi,Shigenori Honda,Yuzuru Kanakura,Yoshiaki Tomiyama, EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vol. 41, No. 1, p. 79-90, 2013/01
  • [Molecular targets of anti-platelet and anti-coagulant drugs]., Tomiyama Y,Kashiwagi H, Nihon rinsho. Japanese journal of clinical medicine, Vol. 70 Suppl 8, p. 263-267, 2012/11
  • Recognition of highly restricted regions in the beta-propeller domain of alpha IIb by platelet-associated anti-alpha IIb beta 3 autoantibodies in primary immune thrombocytopenia, Kazunobu Kiyomizu,Hirokazu Kashiwagi,Tsuyoshi Nakazawa,Seiji Tadokoro,Shigenori Honda,Yuzuru Kanakura,Yoshiaki Tomiyama, BLOOD, AMER SOC HEMATOLOGY, Vol. 120, No. 7, p. 1499-1509, 2012/08
  • 血栓形成の分子機構;血小板機能異常症の解析からみた最近の進歩, 2012/03
  • [Idiopathic thrombocytopenic purpura (ITP)]., Kashiwagi H,Tomiyama Y, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 53, No. 2, p. 178-184, 2012/02
  • Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab, Sumiyuki Nishida,Tomio Kawasaki,Hirokazu Kashiwagi,Atsuyoshi Morishima,Yoshihiro Hishitani,Mari Kawai,Toru Hirano,Taeko Ishii,Keisuke Hagihara,Yoshihito Shima,Masashi Narazaki,Atsushi Ogata,Yoshihiro Oka,Tadamitsu Kishimoto,Toshio Tanaka, MODERN RHEUMATOLOGY, SPRINGER, Vol. 21, No. 4, p. 420-422, 2011/08
  • Fetal and neonatal anemia associated with anti-Jr(a): A case report showing a poorly hemolytic mechanism, Naoko Sasamoto,Takuji Tomimatsu,Keisuke Nagamine,Machiko Oshida,Hirokazu Kashiwagi,Shinsuke Koyama,Takeshi Kanagawa,Hitomi Arahori,Yoshiaki Tomiyama,Tadashi Kimura, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, WILEY-BLACKWELL, Vol. 37, No. 8, p. 1132-1136, 2011/08
  • Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor., Kamae T,Kiyomizu K,Nakazawa T,Tadokoro S,Kashiwagi H,Honda S,Kanakura Y,Tomiyama Y, J Thromb Haemost, WILEY-BLACKWELL, Vol. 9, No. 5, p. 1040-1048, 2011/05
  • Heterozygous ITGA2B R995W mutation inducing constitutive activation of the alpha IIb beta 3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia, Shinji Kunishima,Hirokazu Kashiwagi,Makoto Otsu,Naoya Takayama,Koji Eto,Masafumi Onodera,Yuji Miyajima,Yasushi Takamatsu,Junji Suzumiya,Kousaku Matsubara,Yoshiaki Tomiyama,Hidehiko Saito, BLOOD, AMER SOC HEMATOLOGY, Vol. 117, No. 20, p. 5479-5484, 2011/05
  • [Effects of anticoagulants and storage temperature on immature platelet fraction % (IPF%) values in stored samples measured by the automated hematology analyzer, XE-5000--utility of CTAD-anticoagulation and room temperature storage]., Nishiyama M,Hayashi S,Kabutomori O,Yamanishi H,Suehisa E,Kurata Y,Kashiwagi H,Tomiyama Y, Rinsho byori. The Japanese journal of clinical pathology, Vol. 59, No. 5, p. 452-458, 2011/05
  • GPVI(Glycoprotein VI), 2011/01
  • A potential role for α-actinin in inside-out αIIbβ3 signaling., Tadokoro S,Nakazawa T,Kamae T,Kiyomizu K,Kashiwagi H,Honda S,Kanakura Y,Tomiyama Y, Blood, AMER SOC HEMATOLOGY, Vol. 117, No. 1, p. 250-258, 2011/01
  • Molecular analysis of a patient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies., Kashiwagi H,Kiyomizu K,Kamae T,Nakazawa T,Tadokoro S,Takiguchi S,Doki Y,Kanakura Y,Tomiyama Y, Int J Hematol, SPRINGER TOKYO, Vol. 93, No. 1, p. 106-111, 2011/01
  • [Therapeutic choice for the chronic myeloid leukemia patients in chronic phase showing late suboptimal response to imatinib]., Matsumura I,Nannya Y,Nagai T,Tanimoto K,Fujikawa K,Kasai M,Inaguma Y,Takeuchi M,Niimi H,Kashiwagi H,Imamura Y,Yagi T,Sakamoto E,Okabe M,Aoki G,Katayama T,Okada M,Adachi Y,Saburi Y,Kizaki M, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 51, No. 12, p. 1762-1768, 2010/12
  • Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2 EMBRYONIC/NEONATAL LETHALITY OF CLEC-2-DEFICIENT MICE BY BLOOD/LYMPHATIC MISCONNECTIONS AND IMPAIRED THROMBUS FORMATION OF CLEC-2-DEFICIENT PLATELETS, Katsue Suzuki-Inoue,Osamu Inoue,Guo Ding,Satoshi Nishimura,Kazuya Hokamura,Koji Eto,Hirokazu Kashiwagi,Yoshiaki Tomiyama,Yutaka Yatomi,Kazuo Umemura,Yonchol Shin,Masanori Hirashima,Yukio Ozaki, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 285, No. 32, p. 24494-24507, 2010/08
  • [Comparison between two methods for the measurement reticulated platelet and their clinical significance--flow cytometry (FCM) method and IPF method Using automated hematology analyzer (XE-2000)]., Hayashi S,Nishiyama M,Suehisa E,Kashiwagi H,Kurata Y,Tomiyama Y, Rinsho byori. The Japanese journal of clinical pathology, Vol. 57, No. 11, p. 1039-1044, 2009/11
  • Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency, M. Akiyama,H. Kashiwagi,K. Todo,M. Moroi,M. C. Berndt,H. Kojima,Y. Kanakura,Yoshi Tomiyama, Journal of Thrombosis and Haemostasis, Vol. 7, No. 8, p. 1373-1383, 2009
  • 抗血小板抗体出現により水頭症と尿路結石の管理に難渋した血小板無力症の1例, Vol. 49, No. 9, p. 1129-1129, 2008/09
  • 知っておきたい血管医学用語「セマフォリン」, 2008/04
  • カンナビノイド-1受容体拮抗薬リモナバン(ト)の過体重患者における体重減少および心血管危険因子に対する効果, 2007/12
  • 特発性血小板減少性紫斑病の妊娠、分娩に対する治療はどのようにすればよいのか?, 2007/10
  • 血小板寒冷凝集素により偽性血小板減少症を呈した4例, 2006/08
  • [Four cases of pseudothrombocytopenia due to platelet cold agglutinins]., Kurata Y,Hayashi S,Jouzaki K,Konishi I,Kashiwagi H,Tomiyama Y, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 47, No. 8, p. 781-786, 2006/08
  • Critical role of ADP interaction with P2Y12 receptor in the maintenance of αIIbβ3 activation: Association with Rap1B activation, T. Kamae,M. Shiraga,H. Kashiwagi,H. Kato,S. Tadokoro,Y. Kurata,Yoshi Tomiyama,Y. Kanakura, Journal of Thrombosis and Haemostasis, Vol. 4, No. 6, p. 1379-1387, 2006/06
  • Adiponectin acts as an endogenous antithrombotic factor, H Kato,H Kashiwagi,M Shiraga,S Tadokoro,T Kamae,H Ujiie,S Honda,S Miyata,Y Ijiri,J Yamamoto,N Maeda,T Funahashi,Y Kurata,Shimomura, I,Y Tomiyama,Y Kanakura, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, Vol. 26, No. 1, p. 224-230, 2006/01
  • Impaired platelet function in a patient with P2Y(12) deficiency caused by a mutation in the translation initiation codon, M Shiraga,S Miyata,H Kato,H Kashiwagi,S Honda,Y Kurata,Y Tomiyama,Y Kanakura, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, Vol. 3, No. 10, p. 2315-2323, 2005/10
  • Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A, H Kashiwagi,M Shiraga,H Kato,T Kamae,N Yamamoto,S Tadokoro,Y Kurata,Y Tomiyama,Y Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 106, No. 3, p. 913-921, 2005/08
  • SHPS-1 negatively regulates integrin alpha(IIb)beta(3) function through CD47 without disturbing FAK phosphorylation, H Kato,S Honda,H Yoshida,H Kashiwagi,M Shiraga,N Honma,Y Kuratai,A Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBL LTD, Vol. 3, No. 4, p. 763-774, 2005/04
  • Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage, H. Kashiwagi,M. Shiraga,H. Kato,S. Honda,M. Sako,Y. Kurata,Y. Kanakura,Y. Tomiyama, Journal of Thrombosis and Haemostasis, Vol. 3, No. 2, p. 361-368, 2005/02
  • Amino acid mutagenesis within ligand-binding loops in alpha(v), confers loss-of-function or gain-of-function phenotype on integrin alpha(v)beta(3), S Honda,H Kashiwagi,T Kiyoi,H Kato,S Kosugi,M Shiraga,Y Kurata,Y Tomiyama, THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN, Vol. 92, No. 5, p. 1092-1098, 2004/11
  • [Thrombogenesis and activation of beta 3 integrins]., Kashiwagi H,Toyama Y, [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 45, No. 5, p. 341-346, 2004/05
  • Activation of integrin aIIbb3 in the glycoprotein Ib-high population of a megakaryocytic cell line, CMK, by inside-out signaling., Kashiwagi H,Shiraga M,Honda S,Kosugi S,Kamae T,Kato H,Kurata Y,Tomiyama Y, J Thromb Haemost, BLACKWELL PUBL LTD, Vol. 2, No. 1, p. 177-186, 2004/01
  • Localized relapse in bone marrow in a posttransplantation patient with t(6;9) acute myeloid leukemia, T Maeda,S Kosugi,H Ujiie,K Osumi,T Fukui,H Yoshida,H Kashiwagi,J Ishikawa,Y Tomiyama,Y Matsuzawa, INTERNATIONAL JOURNAL OF HEMATOLOGY, CARDEN JENNINGS PUBL CO LTD, Vol. 77, No. 5, p. 522-525, 2003/06
  • A naturally occurring Tyr143Mis alpha(IIb) mutation abolishes 04 alpha(IIb)beta(3) function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects, T Kiyoi,Y Tomiyama,S Honda,S Tadokoro,M Arai,H Kashiwagi,S Kosugi,H Kato,Y Kurata,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 101, No. 9, p. 3485-3491, 2003/05
  • Successful second allogeneic peripheral blood stem cell transplantation and donor lymphocyte infusion in patients with relapsed acute leukemia using the same donors as for the initial allogeneic bone marrow transplantation, J. Ishikawa,T. Maeda,H. Kashiwagi,H. Yoshida,I. Takahashi,S. I. Kawamoto,M. Yamada,H. Kato,T. Nishiura,Y. Tomiyama,Y. Matsuzawa, Bone Marrow Transplantation, Vol. 31, No. 11, p. 1057-1059, 2003
  • Missense mutations in the beta(3) subunit have a different impact on the expression and function between alpha(IIb)beta(3) and alpha(v)beta(3), S Tadokoro,Y Tomiyama,S Honda,H Kashiwagi,S Kosugi,M Shiraga,T Kiyoi,Y Kurata,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 99, No. 3, p. 931-938, 2002/02
  • Missense mutations in the beta(3) subunit have a different impact on the expression and function between alpha(IIb)beta(3) and alpha(v)beta(3), S Tadokoro,Y Tomiyama,S Honda,H Kashiwagi,S Kosugi,M Shiraga,T Kiyoi,Y Kurata,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 99, No. 3, p. 931-938, 2002/02
  • Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb, S Kosugi,Y Tomiyama,S Honda,H Kato,T Kiyoi,H Kashiwagi,Y Kurata,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 98, No. 6, p. 1819-1827, 2001/09
  • Analyses of genetic abnormalities in type ICD36 deficiency in Japan: identification and cell biological characterization of two novel mutations that cause CD36 deficiency in man, H Kashiwagi,Y Tomiyama,S Nozaki,T Kiyoi,S Tadokoro,K Matsumoto,S Honda,S Kosugi,Y Kurata,Y Matsuzawa, HUMAN GENETICS, SPRINGER-VERLAG, Vol. 108, No. 6, p. 459-466, 2001/06
  • Diagnostic value of tests for reticulated platelets, plasma glycocalicin, and thrombopoietin levels for discriminating between hyperdestructive and hypoplastic thrombocytopenia, Y Kurata,S Hayashi,T Kiyoi,S Kosugi,H Kashiwagi,S Honda,Y Tomiyama, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, AMER SOC CLIN PATHOLOGISTS, Vol. 115, No. 5, p. 656-664, 2001/05
  • Reduced adhesion of monocyte-derived macrophages from CD36-deficient patients to type I collagen, M Janabi,S Yamashita,K Hirano,K Matsumoto,N Sakai,H Hiraoka,H Kashiwagi,Y Tomiyama,S Nozaki,Y Matsuzawa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 283, No. 1, p. 26-30, 2001/04
  • Anti-alpha(v)beta(3) antibodies in chronic immune thrombocytopenic purpura, S Kosugi,Y Tomiyama,S Honda,H Kashiwagi,M Shiraga,S Tadokoro,T Kiyoi,Y Kurata,Y Matsuzawa, THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN, Vol. 85, No. 1, p. 36-41, 2001/01
  • Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit, S Honda,Y Tomiyama,N Pampori,H Kashiwagi,T Kiyoi,S Kosugi,S Tadokoro,Y Kurata,SJ Shattil,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 97, No. 1, p. 175-182, 2001/01
  • A single nucleotide insertion in codon 317 of the CD36 gene leads to CD36 deficiency, H Kashiwagi,Y Tomiyama,S Nozaki,S Honda,S Kosugi,M Shiraga,T Nakagawa,N Nagao,Y Kanakura,Y Kurata,Y Matsuzawa, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, AMER HEART ASSOC, Vol. 16, No. 8, p. 1026-1032, 1996/08
  • Platelet-associated anti-glycoprotein (GP) IIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura mainly recognize cation-dependent conformations: Comparison with the epitopes of serum autoantibodies, S Kosugi,Y Tomiyama,M Shiraga,H Kashiwagi,H Mizutani,Y Kanakura,Y Kurata,Y Matsuzawa, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 75, No. 2, p. 339-345, 1996/02
  • MONOCLONAL ANTICARDIOLIPIN AUTOANTIBODIES ESTABLISHED FROM THE (NEW-ZEALAND WHITE X BXSB)F-1 MOUSE MODEL OF ANTIPHOSPHOLIPID SYNDROME CROSS-REACT WITH OXIDIZED LOW-DENSITY-LIPOPROTEIN, H MIZUTANI,Y KURATA,S KOSUGI,M SHIRAGA,H KASHIWAGI,Y TOMIYAMA,Y KANAKURA,RA GOOD,Y MATSUZAWA, ARTHRITIS AND RHEUMATISM, LIPPINCOTT-RAVEN PUBL, Vol. 38, No. 10, p. 1382-1388, 1995/10
  • FAMILY STUDIES OF TYPE-II CD36 DEFICIENT SUBJECTS - LINKAGE OF A CD36 ALLELE TO A PLATELET-SPECIFIC MESSENGER-RNA EXPRESSION DEFECT(S) CAUSING TYPE-II CD36 DEFICIENCY, H KASHIWAGI,Y TOMIYAMA,S KOSUGI,M SHIRAGA,RH LIPSKY,N NAGAO,Y KANAKURA,Y KURATA,Y MATSUZAWA, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 74, No. 2, p. 758-763, 1995/08
  • ABNORMAL PROCESSING OF THE GLYCOPROTEIN IIB TRANSCRIPT DUE TO A NONSENSE MUTATION IN EXON-17 ASSOCIATED WITH GLANZMANNS-THROMBASTHENIA, Y TOMIYAMA,H KASHIWAGI,S KOSUGI,M SHIRAGA,Y KANAYAMA,Y KURATA,Y MATSUZAWA, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 73, No. 5, p. 756-762, 1995/05
  • MOLECULAR-BASIS OF CD36 DEFICIENCY - EVIDENCE THAT A C-478-]T SUBSTITUTION (PROLINE90-]SERINE) IN CD36 CDNA ACCOUNTS FOR CD36 DEFICIENCY, H KASHIWAGI,Y TOMIYAMA,S HONDA,S KOSUGI,M SHIRAGA,N NAGAO,S SEKIGUCHI,Y KANAYAMA,Y KURATA,Y MATSUZAWA, JOURNAL OF CLINICAL INVESTIGATION, ROCKEFELLER UNIV PRESS, Vol. 95, No. 3, p. 1040-1046, 1995/03
  • CYCLIC THROMBOCYTOPENIA ASSOCIATED WITH IGM ANTI-GPIIB-IIIA AUTOANTIBODIES, S KOSUGI,Y TOMIYAMA,M SHIRAGA,H KASHIWAGI,H NAKAO,Y KANAYAMA,Y KURATA,Y MATSUZAWA, BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, Vol. 88, No. 4, p. 809-815, 1994/12
  • IDENTIFICATION OF MOLECULAR DEFECTS IN A SUBJECT WITH TYPE-I CD36 DEFICIENCY, H KASHIWAGI,Y TOMIYAMA,S KOSUGI,M SHIRAGA,RH LIPSKY,Y KANAYAMA,Y KURATA,Y MATSUZAWA, BLOOD, W B SAUNDERS CO, Vol. 83, No. 12, p. 3545-3552, 1994/06
  • DEMONSTRATION OF A MARKED REDUCTION IN THE AMOUNT OF GPIIB IN MOST TYPE-II PATIENTS WITH GLANZMANNS-THROMBASTHENIA, Y TOMIYAMA,H KASHIWAGI,S KOSUGI,M SHIRAGA,S KINOSHITA,Y KANAYAMA,Y KURATA,Y MATSUZAWA, BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, Vol. 87, No. 1, p. 119-124, 1994/05
  • HIGH-TITER ANTINUCLEAR ANTIBODIES, ANTI-SSA/RO ANTIBODIES AND ANTINUCLEAR RNP ANTIBODIES IN PATIENTS WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA, Y KURATA,S MIYAGAWA,S KOSUGI,H KASHIWAGI,S HONDA,H MIZUTANI,Y TOMIYAMA,Y KANAYAMA,Y MATSUZAWA, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 71, No. 2, p. 184-187, 1994/02
  • ELEVATED PLATELET-ASSOCIATED IGG IN SLE PATIENTS DUE TO ANTIPLATETLET AUTOANTIBODY - DIFFERENTIATION BETWEEN AUTOANTIBODIES AND IMMUNE-COMPLEXES BY ETHER ELUTION, Y KURATA,S HAYASHI,S KOSUGI,H KASHIWAGI,Y TOMIYAMA,Y KANAYAMA,Y MATSUZAWA, BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, Vol. 85, No. 4, p. 723-728, 1993/12
  • EXPRESSION OF GPIV AND NAK(A) ANTIGEN ON MONOCYTES IN NAK(A)-NEGATIVE SUBJECTS WHOSE PLATELETS LACK GPIV, H TAKE,H KASHIWAGI,Y TOMIYAMA,S HONDA,Y HONDA,H MIZUTANI,T FURUBAYASHI,T KARASUNO,T NISHIURA,Y KANAYAMA,Y KURATA,Y MATSUZAWA, BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, Vol. 84, No. 3, p. 387-391, 1993/07
  • A NOVEL POLYMORPHISM IN GLYCOPROTEIN-IV (REPLACEMENT OF PROLINE-90 BY SERINE) PREDOMINATES IN SUBJECTS WITH PLATELET GPIV DEFICIENCY, H KASHIWAGI,S HONDA,Y TOMIYAMA,H MIZUTANI,H TAKE,Y HONDA,S KOSUGI,Y KANAYAMA,Y KURATA,Y MATSUZAWA, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 69, No. 5, p. 481-484, 1993/05
  • PRESENCE OF THE ENTIRE CODING REGION OF GP-IV MESSENGER-RNA IN NAKA-NEGATIVE PLATELETS, H KASHIWAGI,S HONDA,H TAKE,H MIZUTANI,Y IMAI,T FURUBAYASHI,Y TOMIYAMA,Y KURATA,T YONEZAWA, INTERNATIONAL JOURNAL OF HEMATOLOGY, ELSEVIER SCI IRELAND LTD, Vol. 57, No. 2, p. 153-161, 1993/04
  • Mechanisms of corticosteroid action in immune thrombocytopenic purpura (ITP): Experimental studies using ITP-prone mice, (NZW x BXSB) F1, H. Mizutani,T. Furubayashi,Y. Imai,H. Kashiwagi,S. Honda,H. Take,Y. Kurata,T. Yonezawa,S. Tarui,S. Ikehara, Blood, Vol. 79, No. 4, p. 942-947, 1992
  • Effects of splenectomy on immune thrombocytopenic purpura in (NZW x BXSB) F1 mice: Analyses of platelet kinetics and anti-platelet antibody production, H. Mizutani,T. Furubayashi,H. Kashiwagi,S. Honda,H. Take,Y. Kurata,T. Yonezawa,S. Tarui,S. Ikehara, Thrombosis and Haemostasis, Vol. 67, No. 5, p. 563-566, 1992
  • B cells expressing CD5 antigen are markedly increased in peripheral blood and spleen lymphocytes from patients with immune thrombocytopenic purpura, Hajime Mizutani,Takayasu Furubayashi,Hirokazu Kashiwagi,Shigenori Honda,Hironori Take,Yoshiyuki Kurata,Takeshi Yonezawa,Seiichiro Tarui, British Journal of Haematology, Vol. 78, No. 4, p. 474-479, 1991

Misc.

  • 成人特発性血小板減少性紫斑病治療の参照ガイド 2019改訂版, Vol. 60, No. 8, p. 877-896, 2019/08
  • 後天性血小板機能異常症, 柏木浩和, 日本血栓止血学会誌, Vol. 29, No. 6, 2018/12
  • 患者さんからよく尋ねられる内科診療のFAQ 第8章 血液 どれくらいまでなら運動してもいいですか?[28歳 女性,慢性特発性血小板減少性紫斑病], 柏木浩和, 内科, Vol. 120, No. 3, 2017/09
  • やさしく考える抗血栓薬・止血薬 こんなとき,どうする?2)出血症状が出たときはどうする?, 柏木浩和, レジデントノート, Vol. 19, No. 7, 2017/08/01
  • 出血症状が出たときはどうする? (特集 やさしく考える抗血栓薬・止血薬 : 凝固・線溶の基本から、病態ごとの使い分けまで) -- (こんなとき,どうする?), Vol. 19, No. 7, p. 1212-1218, 2017/08
  • 動脈・静脈疾患の基礎研究動向 血小板機能と抗血小板薬, 柏木浩和, 日本臨床, Vol. 75, 2017/07/20
  • 中鎖脂肪酸療法により心不全症状が改善したCD36欠損症の一例, 平野賢一,長井直子,橋本千佳子,鈴木朗,山口知是,李銘,原康洋,柏木浩和,冨山佳昭,長坂博範, 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), Vol. 49th, 2017/06/25
  • The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese, Yoichiro Morikawa,Hisashi Kato,Keigo Akuta,Hirokazu Kashiwagi,Shigenori Honda,Yuzuru Kanakura,Yoshiaki Tomiyama, BLOOD, AMER SOC HEMATOLOGY, Vol. 128, No. 22, 2016/12
  • 後天性フォン・ヴィレブランド症候群に併発した小脳出血の1例, 尾崎友彦,中村元,横田千里,角野喜則,村上知義,浅井克則,西田武生,倉重隆明,柏木浩和,吉峰俊樹, Neurosurgical Emergency, (NPO)日本脳神経外科救急学会, Vol. 20, No. 3, p. 456-456, 2016/01
  • Efficacy and safety of anagrelide for essential thrombocythemia, 柏木 浩和, 血液内科 = Hematology, 科学評論社, Vol. 71, No. 4, p. 523-528, 2015/10
  • Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders, M. Sakuragi,S. Hayashi,M. Maruyama,O. Kabutomori,T. Kiyokawa,K. Nagamine,H. Kato,H. Kashiwagi,Y. Kanakura,Y. Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 13, p. 868-869, 2015/06
  • Severe bleeding tendency and impaired platelet function in a patient with CalDAG-GEFI deficiency, H. Kato,Y. Nakazawa,H. Kashiwagi,S. Tadokoro,Y. Morikawa,D. Morita,Y. Kurokawa,Y. Kanakura,Y. Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 13, p. 225-225, 2015/06
  • alpha IIb( R990W), a Constitutive Activating Mutation of Integrin alpha IIb beta 3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function, Kazunobu Kiyomizu,Hirokazu Kashiwagi,Shinji Kunishima,Fumiaki Banno,Hisashi Kato,Youichiro Morikawa,Seiji Tadokoro,Koichi Kokame,Shigenori Honda,Toshiyuki Miyata,Yuzuru Kanakura,Yoshiaki Tomiyama, BLOOD, AMER SOC HEMATOLOGY, Vol. 124, No. 21, 2014/12
  • Demonstration of novel gain-of-function mutations of aIIb beta 3: association with macrothrombocytopenia and Glanzmann thrombasthenia-like phenotype, H. Kashiwagi,S. Kunishima,K. Kiyomizu,Y. Amano,H. Shimada,M. Morishita,Y. Kanakura,Y. Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 11, p. 455-455, 2013/07
  • Pathophysiology of primary ITP, 冨山 佳昭,清水 一亘,柏木 浩和, 臨床免疫・アレルギー科, 科学評論社, Vol. 59, No. 6, p. 649-657, 2013/06
  • Epitope analysis of anti-αIIbβ3 autoantibodies in primary ITP:Recognition of highly restricted regions in the β-propeller domain by platelet-associated anti-αIIbβ3 autoantibodies, KIYOMIZU Kazunobu,KASHIWAGI Hirokazu,TOMIYAMA Yoshiaki, Nihon Kessen Shiketsu Gakkaishi, The Japanese Society on Thrombosis and Hemostasis, Vol. 24, No. 4, p. 392-395, 2013
  • ORAL ABSTRACT: NOVEL FORM OF CONGENITAL MACROTHROMBOCYTOPENIA CAUSED BY MUTATIONS IN ITGB2A AND ITGB3, Shinji Kunishima,Hirokazu Kashiwagi,Yoshiaki Tomiyama,Hidehiko Saito, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, WILEY-BLACKWELL, Vol. 34, p. 30-31, 2012/06
  • Idiopathic thrombocytopenic pupura (ITP), KASHIWAGI Hirokazu, 臨床血液, 「臨床血液」編集部, Vol. 53, No. 2, p. 178-184, 2012/02/28
  • Idiopathic thrombocytopenic pupura (ITP), 柏木 浩和,冨山 佳昭, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 53, No. 2, p. 178-184, 2012/02
  • Agonist Stimulation, Talin-1, and Kindlin-3 Are Crucial for alpha(Ib)beta(3) activation in a Human Megakaryoblastic Cell Line, CMK, Tsuyoshi Nakazawa,Seiji Tadokoro,Kazunobu Kiyomizu,Hirokazu Kashiwagi,Shigenori Honda,Yoshiaki Tomiyama,Yuzuru Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 118, No. 21, p. 516-517, 2011/11
  • Identification of epitopes and critical residues for binding of platelet-associated anti-GPIIbIIIa autoantibodies in patients with chronic immune thrombocytopenia, K. Kiyomizu,H. Kashiwagi,T. Nakazawa,T. Kamae,S. Tadokoro,S. Honda,Y. Kanakura,Y. Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 9, p. 329-329, 2011/07
  • alpha-Actinin stabilizes integrins to a low-affinity ligand-binding state in resting platelets, S. Tadokoro,T. Nakazawa,T. Kamae,K. Kiyomizu,H. Kashiwagi,S. Honda,Y. Kanakura,Y. Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 9, p. 261-261, 2011/07
  • Agonist induced alpha(IIB)beta(3) activation in genetically engineered human megakaryoblastic cell line, CMK, T. Nakazawa,T. Kamae,K. Kiyomizu,S. Tadokoro,S. Honda,H. Kashiwagi,Y. Kanakura,Y. Tomiyama, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, WILEY-BLACKWELL, Vol. 9, p. 61-61, 2011/07
  • 知っておきたい血管医学用語(43)GPVI(Glycoprotein VI), Vol. 7, No. 1, p. 67-71, 2011/04
  • Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor., Tsuyoshi Kamae,Kazunobu Kiyomizu,Tsuyoshi Nakazawa,Seiji Tadokoro,Shigenori Honda,Hirokazu Kashiwagi,Yuzuru Kanakura,Yoshiaki Tomiyama, BLOOD, AMER SOC HEMATOLOGY, Vol. 116, No. 21, p. 1046-1046, 2010/11
  • Editorial, KASHIWAGI Hirokazu, 日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis, Vol. 21, No. 3, p. 253-254, 2010/06/01
  • Autoantibodies and Platelet Dysfunction, KASHIWAGI Hirokazu,AKIYAMA Masao,TOMIYAMA Yoshiaki, Japanese Journal of Thrombosis and Hemostasis, The Japanese Society on Thrombosis and Hemostasis, Vol. 21, No. 3, p. 271-277, 2010/06
  • 1. Hemostatic Mechanism and Breakthrough Bleeding, Kashiwagi Hirokazu, J. Jpn. Soc. Intern. Med., The Japanese Society of Internal Medicine, Vol. 98, No. 7, p. 1554-1561, 2009/07
  • A Role for alpha-Actinin in Inside-out alpha IIb beta 3 Signaling, Seiji Tadokoro,Masamichi Shiraga,Hirokazu Kashiwagi,Tsuyoshi Kamae,Masao Akiyama,Tsuyoshi Nakazawa,Yuzuru Kanakura,Yoshiaki Tomiyarria, BLOOD, AMER SOC HEMATOLOGY, Vol. 112, No. 11, p. 650-650, 2008/11
  • 知っておきたい血管医学用語(25)Semaphorin, Vol. 4, No. 4, p. 368-371, 2008/10
  • Diagnosis and treatment of essential thrombocythemia, KASHIWAGI Hirokazu, Nihon Kessen Shiketsu Gakkaishi, The Japanese Society on Thrombosis and Hemostasis, Vol. 19, No. 2, p. 206-209, 2008/04
  • Editorial, KASHIWAGI Hirokazu, 日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis, Vol. 18, No. 6, p. 547-548, 2007/12/01
  • P2Y(12)-independent transient activation and P2Y(12)-dependent prolonged activation of platelet integrin alpha(IIb)beta(3)., Masamichi Shiraga,Tsuyoshi Kamae,Masao Akiyama,Seiji Tadokoro,Hirokazu Kashiwagi,Kenji Oritani,Yoshiyuki Kurata,Yoshiaki Tomiyama,Tuzuru Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 108, No. 11, p. 435A-435A, 2006/11
  • Negative regulation of platelet function by semaphorin 3A, KASHIWAGI Hirokazu,TOMIYAMA Yoshiaki, Nihon Kessen Shiketsu Gakkaishi, The Japanese Society on Thrombosis and Hemostasis, Vol. 16, No. 6, p. 674-677, 2005/12/01
  • Critical role of endogenous ADP via P2Y(12) receptor in maintenance of alpha(Iib)beta(3) activation., T Kamae,M Shiraga,H Kashiwagi,H Kato,S Tadokoro,Y Kurata,Y Tomiyama,Y Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 106, No. 11, p. 472A-473A, 2005/11
  • 新規血小板機能抑制分子としての Semaphorin 3A, Vol. 16, No. 5, 2005/10/01
  • Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A, Kashiwagi H,Shiraga M,Kato H,Kamae T,Yamamoto N,Tadokoro S,Kurata Y,Tomiyama Y,Kanakura Y, Blood, AMER SOC HEMATOLOGY, Vol. 104, No. 11, p. 432A-432A, 2005/08
  • Impaired platelet function in a P2Y(12)-deficient patient caused by a mutation in the translation initiation codon., M Shiraga,S Miyata,T Kamae,H Kato,T Kiyoi,H Kashiwagi,S Honda,Y Kurata,Y Tomiyama,Y Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 104, No. 11, p. 212A-212A, 2004/11
  • Enhanced platelet aggregation and thrombogenic tendency in adiponectin-deficient mice, H Kato,H Kashiwagi,M Shiraga,S Honda,S Miyat,J Yamamoto,Y Kurata,T Funahashi,L Shimomura,Y Tomiyama,Y Kanakura, BLOOD, AMER SOC HEMATOLOGY, Vol. 104, No. 11, p. 228A-229A, 2004/11
  • Thrombogenesis and activation of β3 integrins, KASHIWAGI Hirokazu, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 45, No. 5, p. 341-346, 2004/05/30
  • Interaction of CD47 with SHPS-1 negatively regulates platelet function, H Kato,Y Tomiyama,S Honda,H Yoshida,H Kashiwagi,S Kosugi,M Shiraga,T Kiyoi,N Honma,Y Kurata,Y Matsuzawa, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER SCI IRELAND LTD, Vol. 4, No. 2, p. 145-145, 2003/09
  • Analysis of Arg-Gly-Asp-contact sites in the alpha v subunit of integrin alpha v beta 3 employing single amino acid mutations, S Honda,Y Tomiyama,H Kashiwagi,T Kiyoi,H Kato,S Kosugi,M Shiraga,Y Kurata,Y Matsuzawa, ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER SCI IRELAND LTD, Vol. 4, No. 2, p. 144-145, 2003/09
  • Structure and Functions of CD 36, and Pathophysiology and Genetics of CD 36 Deficiency, KASHIWAGI Hirokazu,TOMIYAMA Yoshiaki, Nihon Kessen Shiketsu Gakkaishi, The Japanese Society on Thrombosis and Hemostasis, Vol. 14, No. 4, p. 295-303, 2003/08/01
  • Interaction of CD47 with SHPS-1 negatively regulates platelet function., H Kato,Y Tomiyama,S Honda,H Yoshida,H Kashiwagi,S Kosugi,M Shiraga,T Kiyoi,N Honma,Y Kurata,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 100, No. 11, p. 473A-473A, 2002/11
  • Analyses of genetic abnormalities in type I CD36 deficiency in Japan: Identification and cell biological characterization of two novel mutations that cause CD36 deficiency in man., Kashiwagi H,Tomiyama Y,Nozaki S,Kiyoi T,Tadokoro S,Matsumoto K,Honda S,Kosugi S,Kurata Y,Matsuzawa Y, Human Genet, AMER SOC HEMATOLOGY, Vol. 96, No. 11, p. 254A-254A, 2001/06
  • β3インテグリン受容体を標的とした血管病変制御薬の開発 (平成12年度研究奨励金受領報告) -- (研究課題 オーファン受容体と創薬), Vol. 16, p. 105-108, 2001
  • Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic autoimmune thrombocytopenic purpura recognizing epitopes in very close proximity to the ligand-binding site of GPIIb., S Kosugi,Y Tomiyama,S Honda,H Kashiwagi,H Kato,T Kiyoi,Y Kurata,Y Matsuzawa, BLOOD, AMER SOC HEMATOLOGY, Vol. 96, No. 11, p. 248A-248A, 2000/11
  • Comparison of reticulated platelet count with plasma glycocalicin concentration as a marker of platelet turnover in patients with thrombocytopenic disorders, HAYASHI Satoru,OSHIDA Machiko,KIYOI Teruo,TADOKORO Seiji,KASHIWAGI Hirokazu,HONDA Shigenori,TOMIYAMA Yoshiaki,KURATA Yoshiyuki, 臨床血液, 日本臨床血液学会, Vol. 41, No. 9, p. 705-711, 2000/09/30
  • Comparison of reticulated platelet count with plasma glycocalicin concentration as a marker of platelet turnover in patients with thrombocytopenic disorders, HAYASHI Satoru,OSHIDA Machiko,KIYOI Teruo,TADOKORO Seiji,KASHIWAGI Hirokazu,HONDA Shigenori,TOMIYAMA Yoshiaki,KURATA Yoshiyuki, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 41, No. 9, p. 705-711, 2000
  • The Sensitivity, Specificity and Predictive Value of PAIgG, Reticulated Platelets, Thrombopoietin Levels, and Platelet Size for the Differential Diagnosis of Thrombocytopenia, KURATA Yohiyuki,HAYASHI Satoru,OSHIDA Machiko,KIYOI Teruo,TADOKORO Seiji,KASHIWAGI Hirokazu,HONDA Shigenori,TOMIYAMA Yoshiaki, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 40, No. 11, p. 1152-1159, 1999/11/30
  • Different effects on expression and ligand binding function between alpha(iib)beta(3) and alpha v beta(3) by missense mutations in the beta 3 subunit in Glanzmann thrombasthenia, S Tadokoro,Y Tomiyama,S Honda,H Kashiwagi,T Kiyoi,Y Kurata,Y Matsuzawa, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, p. 250-250, 1999/08
  • Ligand-binding sites on the alpha V subunit of integrin alpha v beta 3, S Honda,Y Tomiyama,H Kashiwagi,S Tadokoro,T Kiyoi,Y Kurata,Y Matsuzawa, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, p. 250-250, 1999/08
  • A mutation in the extracellular cysteine-rich repeat region of the b3 subunit activates integrins aIIbb3 and aVb3., Kashiwagi H,Tomiyama Y,Tadokoro S,Honda S,Shiraga M,Mizutani H,Handa M,Kurata Y,Matsuzawa Y,Shattil SJ, Blood, AMER SOC HEMATOLOGY, Vol. 93, No. 8, p. 2559-2568, 1999/08
  • Reticulated Platelet Determination: Methodologies and Applications for the Evaluation of Thrombocytopenic Disorders, HAYASHI Satoru,OSHIDA Machiko,KIYOI Teruo,TADOKORO Seiji,KASHIWAGI Hirokazu,HONDA Shigenori,TOMIYAMA Yoshiaki,KURATA Yoshiyuki, 臨床血液, 日本臨床血液学会, Vol. 40, No. 3, p. 205-212, 1999/03/30
  • Reticulated Platelet Determination: Methodologies and Applications for the Evaluation of Thrombocytopenic Disorders, HAYASHI Satoru,OSHIDA Machiko,KIYOI Teruo,TADOKORO Seiji,KASHIWAGI Hirokazu,HONDA Shigenori,TOMIYAMA Yoshiaki,KURATA Yoshiyuki, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 40, No. 3, p. 205-212, 1999
  • Effect of a His280Pro substitution in integrin beta 3 subunit on alpha IIb beta 3 and alpha v beta 3 expression., S Tadokoro,Y Tomiyama,S Honda,H Kashiwagi,M Shiraga,T Kiyoi,Y Kurata,Y Matsuzawa, BLOOD, W B SAUNDERS CO, Vol. 92, No. 10, p. 344A-344A, 1998/11
  • A mutation in the extracelullar cysteine-rich repeat region of the beta(3) subunit activates integrins alpha(IIb)beta(3) and alpha(v)beta(3)., H Kashiwagi,Y Tomiyama,S Tadokoro,S Honda,M Shiraga,T Kiyoi,Y Kurata,Y Matsuzawa,SJ Shattil, BLOOD, W B SAUNDERS CO, Vol. 92, No. 10, p. 304A-304A, 1998/11
  • Integrin Cytoplasmic Region-binding Proteins, KASHIWAGI Hirokazu, Jpn J Thromb Hemost, The Japanese Society on Thrombosis and Hemostasis, Vol. 9, No. 5, p. 375-377, 1998/10/01
  • Affinity modulation of the platelet integrin alpha(IIb)beta(3) by alpha-chymotrypsin: A possible role for Na+/Ca2+ exchanger, M Shiraga,Y Tomiyama,S Honda,H Kashiwagi,S Kosugi,M Handa,Y Ikeda,Y Kanakura,Y Kurata,Y Matsuzawa, BLOOD, W B SAUNDERS CO, Vol. 88, No. 7, p. 2594-2602, 1996/10
  • CD36 as an Oxidized LDL Receptor - Insight from CD36 Deficient Subjects, NOZAKI Shuichi,KASHIWAGI Hirokazu,MATSUZAWA Yuji, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 24, No. 4, p. 181-185, 1996/08/31
  • Molecular Basis of CD36 Deficiency, KASHIWAGI Hirokazu, 日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis, Vol. 7, No. 2, p. 85-92, 1996/04/01
  • CD36 as an Oxidized LDL Receptor-Insight from CD36 Deficient Subjects, NOZAKI Shuichi,KASHIWAGI Hirokazu,MATSUZAWA Yuji, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 24, No. 4, p. 181-185, 1996
  • CD36 as an Oxidized LDL Receptor-Insight from CD36 Deficient Subjects, NOZAKI Shuichi,KASHIWAGI Hirokazu,MATSUZAWA Yuji, The Journal of Japan Atherosclerosis Society, Japan Atherosclerosis Society, Vol. 24, No. 4, p. 181-185, 1996
  • Molecular Basis of CD36 Deficiency, KASHIWAGI Hirokazu, Nihon Kessen Shiketsu Gakkaishi, The Japanese Society on Thrombosis and Hemostasis, Vol. 7, No. 2, p. 85-92, 1996
  • A polyadenylation signal mutation in the GPIIb gene associated with Glanzmann's thrombasthenia., Y Tomiyama,S Honda,S Tadokoro,H Kashiwagi,M Shiraga,S Kosugi,Y Kanakura,Y Kurata,Y Matsuzawa, BLOOD, W B SAUNDERS CO, Vol. 86, No. 10, p. 313-313, 1995/11
  • Affinity modulation of the integrin alpha IIb beta 3 in human platelets by alpha-chymotrypsin: A possible role for Na+/Ca2+ exchanger., M Shiraga,Y Tomiyama,S Honda,H Kashiwagi,S Kosugi,M Handa,Y Ikeda,Y Kanakura,Y Kurata,Y Matsuzawa, BLOOD, W B SAUNDERS CO, Vol. 86, No. 10, p. 1792-1792, 1995/11
  • Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic ITP mainly recognize cation-dependent conformations: Comparison with the epitopes of serum autoantibodies., S Kosugi,Y Tomiyama,M Shiraga,H Kashiwagi,S Honda,S Tadokoro,Y Kanakura,Y Kurata,Y Matsuzawa, BLOOD, W B SAUNDERS CO, Vol. 86, No. 10, p. 2146-2146, 1995/11
  • REDUCED UPTAKE OF OXIDIZED LOW-DENSITY LIPOPROTEINS IN MONOCYTE-DERIVED MACROPHAGES FROM CD36-DEFICIENT SUBJECTS, S NOZAKI,H KASHIWAGI,S YAMASHITA,T NAKAGAWA,B KOSTNER,Y TOMIYAMA,A NAKATA,M ISHIGAMI,JI MIYAGAWA,K KAMEDATAKEMURA,Y KURATA,Y MATSUZAWA, JOURNAL OF CLINICAL INVESTIGATION, ROCKEFELLER UNIV PRESS, Vol. 96, No. 4, p. 1859-1865, 1995/10
  • Blood type antigen and genetic analysis.2.Blood platelets.Genetic analysis of GPIV defect ( Naka negative ) cases., 柏木 浩和,冨山 佳昭,倉田 義之, Journal of the Japan Society of Blood Transfusion, The Japan Society of Transfusion Medicine and Cell Therapy, Vol. 40, No. 1, p. 126-128, 1994
  • Pathogenic Relavance of Platelet-Associated Autoantibodies in Chronic ITP. Studies before and after Splenectomy in Three Patients with Chronic ITP by Direct Immunoprecipitation Procedure., TOMIYAMA Yoshiaki,TAKE Hironori,KOSUGI Satoru,KASHIWAGI Hirokazu,KANAYAMA Yoshio,KURATA Yoshiyuki,MATSUZAWA Yuji, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 34, No. 1, p. 21-27, 1993
  • Comparison of the sensitivity of ABC MACE, MACE, MAIPA and FCM for the detection of anti-platelet alloantibodies., Kosugi Satoru,Tomiyama Yoshiaki,Kashiwagi Hirokazu,Kanayama Yoshio,Kurata Yoshiyuki,Matsuzawa Yuji, Journal of the Japan Society of Blood Transfusion, The Japan Society of Transfusion Medicine and Cell Therapy, Vol. 39, No. 4, p. 720-725, 1993
  • DETECTION OF NAK(A) ANTIGEN AND GP-IV (CD36) MESSENGER-RNA IN MONOCYTES OF NAK(A)-NEGATIVE SUBJECTS, H KASHIWAGI,S HONDA,H TAKE,H MIZUTANI,Y IMAI,Y TOMIYAMA,Y KURATA,T YONEZAWA, THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, Vol. 67, No. 3, p. 384-385, 1992/03
  • Clinical Significance of Antinuclear Antibody in Patients with Idiopathic Thrombocytopenic Purpura, KURATA Yoshiyuki,MIYAGAWA Sachiko,KOSUGI Satoru,KASHIWAGI Hirokazu,HONDA Shigenori,MIZUTANI Hajime,TOMIYAMA Yoshiaki,KANAYAMA Yoshio,MATSUZAWA Yuji, Rinsho Ketsueki, The Japanese Society of Hematology, Vol. 33, No. 9, p. 1178-1182, 1992
  • Gene analysis of platelet-Naka antigen expression on monocytes in platelet-Naka- subjects., Honda Shigenori,Kashiwagi Hirokazu,Take Hironori,Imai Yumiko,Tomiyama Yoshiaki,Furubayashi Takayasu,Mizutani Hajime,Kurata Yoshiyuki,Yonezawa Takeshi, Journal of the Japan Society of Blood Transfusion, The Japan Society of Transfusion Medicine and Cell Therapy, Vol. 37, No. 6, p. 817-821, 1991
  • Cerebrovascular Incidents in Diabetes Mellitus and Catecholamines, KASHIWAGI Hirokazu,FUSHIMI Hisako,HORIE Hiroaki,KISHINO Bunichiro,INOUE Toru,KAMEYAMA Masakuni, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 17, No. 5, p. 695-698, 1989
  • Cerebrovascular Incidents in Diabetes Mellitus and Catecholamines, KASHIWAGI Hirokazu,FUSHIMI Hisako,HORIE Hiroaki,KISHINO Bunichiro,INOUE Toru,KAMEYAMA Masakuni, The Journal of Japan Atherosclerosis Society, Japan Atherosclerosis Society, Vol. 17, No. 5, p. 695-698, 1989
  • Cerebrovascular Incidents in Diabetes Mellitus and Catecholamines, KASHIWAGI Hirokazu,FUSHIMI Hisako,HORIE Hiroaki,KISHINO Bunichiro,INOUE Toru,KAMEYAMA Masakuni, Journal of Atherosclerosis and Thrombosis, Japan Atherosclerosis Society, Vol. 17, No. 5, p. 695-698, 1989
  • A case of renal hypouricemia associated with increased plasma oxypurine concentration due to its decreased excretion, KAWACHI Masanori,KONO Norio,KIYOKAWA Hiroaki,KASHIWAGI Hirokazu,MINEO Ikuo,TAJIMA Koji,YAMADA Yuya,HARA Naoko,NAKAJIMA Hiromu,YAMASAKI Tomoyuki,WANG Yan Lin,YORIFUJI Shiro,TARUI Seiichiro, Purine and pyrimidine metabolism, Japanese Society of Gout and Nucleic Acid Metabolism, Vol. 13, No. 1, p. 1-6, 1989

Publications

  • 血小板機能異常症の診断と治療: EBM血液疾患の治療2015-2016(金倉譲、木崎昌弘、鈴木律朗、神田善伸編), 中外医学社, 2014/11
  • Clinical practice for thrombosis and hemostasis abnormality, Yoshiaki Tomiyama, Nakayama Publisher, 2014/11
  • ITPの病態解析: Annual Review血液2014(高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編), 中外医学社, 2014/01
  • 特発性血小板減少性紫斑病(ITP);専門医のための薬物療法Q&A (小松則夫,片山直之,冨山佳昭編), 中外医学社, 2011/10
  • 造血器腫瘍治療 これは困ったぞ、どうしよう?第2版(押味和夫監修, 木崎昌弘, 松村 到編, 中外医学社, 2010/10