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Itoh Yukihiro

伊藤 幸裕

The Institute of Scientific and Industrial Research, Associate Professor

keyword Biological organic chemistry

Research History

  • 2020/06 - Present, Osaka University, The Institute of Scientific and Industrial Research, associate professor
  • 2020/06 - Present, Kyoto Prefectural University of Medicine
  • 2019/04 - 2020/05, Kyoto Prefectural University of Medicine

Research Areas

  • Life sciences, Pharmaceuticals - chemistry and drug development

Papers

  • Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders, Tetsuya Iida,Yukihiro Itoh,Yukari Takahashi,Yasunobu Yamashita,Takashi Kurohara,Yuka Miyake,Makoto Oba,Takayoshi Suzuki, ChemMedChem, Wiley, 2021/02/16
  • N<sup>+</sup>-C-H…O Hydrogen Bonds in Protein-Ligand Complexes and their Application to Drug Design, Yukihiro Itoh,Takashi Kurohara,Takayoshi Suzuki, Journal of Synthetic Organic Chemistry, Japan, The Society of Synthetic Organic Chemistry, Japan, Vol. 78, No. 12, p. 1151-1162, 2020/12/01
  • Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor, Yuka Miyake,Yukihiro Itoh,Yoshinori Suzuma,Hidehiko Kodama,Takashi Kurohara,Yasunobu Yamashita,Remy Narozny,Yutaro Hanatani,Shusaku Uchida,Takayoshi Suzuki, ACS CATALYSIS, AMER CHEMICAL SOC, Vol. 10, No. 10, p. 5383-5392, 2020/05
  • Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl- l -methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols, Shusuke Ogihara,Toru Komatsu,Yukihiro Itoh,Yuka Miyake,Takayoshi Suzuki,Kouichi Yanagi,Yusuke Kimura,Tasuku Ueno,Kenjiro Hanaoka,Hirotatsu Kojima,Takayoshi Okabe,Tetsuo Nagano,Yasuteru Urano, Journal of the American Chemical Society, Vol. 142, No. 1, p. 21-26, 2020
  • Drug discovery researches on modulators of lysine-modifying enzymes based on strategic chemistry approaches, Yukihiro Itoh, Chemical and Pharmaceutical Bulletin, Vol. 68, No. 1, p. 34-45, 2020
  • Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor, Keng Yoon Yeong,Kooi Yeong Khaw,Yukari Takahashi,Yukihiro Itoh,Vikneswaran Murugaiyah,Takayoshi Suzuki, Bioorganic Chemistry, Vol. 94, p. 103403-103403, 2020/01
  • N<sup>+</sup>-C-H···O Hydrogen bonds in protein-ligand complexes, Yukihiro Itoh,Yusuke Nakashima,Shuichiro Tsukamoto,Takashi Kurohara,Miki Suzuki,Yoshitake Sakae,Masayuki Oda,Yuko Okamoto,Takayoshi Suzuki, Scientific Reports, Vol. 9, No. 1, 2019/12/01
  • Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "selectivity Pocket", Substrate-Binding Site, and NAD<sup>+</sup>-Binding Site, Paolo Mellini,Yukihiro Itoh,Elghareeb E. Elboray,Hiroki Tsumoto,Ying Li,Miki Suzuki,Yukari Takahashi,Toshifumi Tojo,Takashi Kurohara,Yuka Miyake,Yuri Miura,Yuki Kitao,Masayuki Kotoku,Tetsuya Iida,Takayoshi Suzuki, Journal of Medicinal Chemistry, Vol. 62, No. 12, p. 5844-5862, 2019/06/27
  • Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors, Pattaporn Jaikhan,Benjaporn Buranrat,Yukihiro Itoh,Jiranan Chotitumnavee,Takashi Kurohara,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry Letters, Vol. 29, No. 10, p. 1173-1176, 2019/05/15
  • Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy, Yuka Miyake,Yukihiro Itoh,Atsushi Hatanaka,Yoshinori Suzuma,Miki Suzuki,Hidehiko Kodama,Yoshinobu Arai,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry, Vol. 27, No. 6, p. 1119-1129, 2019/03/15
  • Design, synthesis, and biological evaluation of a conjugate of 5-fluorouracil and an LSD1 inhibitor, Yosuke Ota,Arisa Nakamura,Elghareeb E. Elboray,Yukihiro Itoh,Takayoshi Suzuki, Chemical and Pharmaceutical Bulletin, Vol. 67, No. 3, p. 192-195, 2019
  • Chemical Protein Degradation Approach and its Application to Epigenetic Targets, Yukihiro Itoh, Chemical Record, Vol. 18, No. 12, p. 1681-1700, 2018/12
  • Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors, Yukihiro Itoh,Miki Suzuki, Bioorganic and Medicinal Chemistry Letters, Vol. 28, No. 16, p. 2723-2727, 2018/09/01
  • Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations, Shuichiro Tsukamoto,Yoshitake Sakae,Yukihiro Itoh,Takayoshi Suzuki,Yuko Okamoto, Journal of Chemical Physics, Vol. 148, No. 12, 2018/03/28
  • Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors, Yosuke Ota,Shin Miyamura,Misaho Araki,Yukihiro Itoh,Shusuke Yasuda,Mitsuharu Masuda,Tomoyuki Taniguchi,Yoshihiro Sowa,Toshiyuki Sakai,Kenichiro Itami,Junichiro Yamaguchi,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry, Vol. 26, No. 3, p. 775-785, 2018/02/01
  • Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors, Taeko Kakizawa,Yosuke Ota,Yukihiro Itoh,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry Letters, Vol. 28, No. 2, p. 167-169, 2018/01/15
  • Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures, Yosuke Ota,Taeko Kakizawa,Yukihiro Itoh,Takayoshi Suzuki, Molecules, Vol. 23, No. 5, 2018
  • Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules, Keiichiro Okuhira,Takuji Shoda,Risa Omura,Nobumichi Ohoka,Takayuki Hattori,Norihito Shibata,Yosuke Demizu,Ryo Sugihara,Asato Ichino,Haruka Kawahara,Yukihiro Itoh,Minoru Ishikawa,Yuichi Hashimoto,Masaaki Kurihara,Susumu Itoh,Hiroyuki Saito,Mikihiko Naito, Molecular Pharmacology, Vol. 91, No. 3, p. 159-166, 2017/03
  • Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors, Yukihiro Itoh,Keisuke Aihara,Paolo Mellini,Toshifumi Tojo,Yosuke Ota,Hiroki Tsumoto,Viswas Raja Solomon,Peng Zhan,Miki Suzuki,Daisuke Ogasawara,Akira Shigenaga,Tsubasa Inokuma,Hidehiko Nakagawa,Naoki Miyata,Tamio Mizukami,Akira Otaka,Takayoshi Suzuki, Peptide Science 2016, p. 165-166, 2017/02/26
  • “Drug” discovery with the help of organic chemistry, Yukihiro Itoh,Takayoshi Suzuki, Yakugaku Zasshi, Vol. 137, No. 3, p. 283-292, 2017
  • Potent mechanism-based sirtuin-2-selective inhibition by an: In situ -generated occupant of the substrate-binding site, "selectivity pocket" and NAD<sup>+</sup>-binding site, Paolo Mellini,Yukihiro Itoh,Hiroki Tsumoto,Ying Li,Miki Suzuki,Natsuko Tokuda,Taeko Kakizawa,Yuri Miura,Jun Takeuchi,Maija Lahtela-Kakkonen,Takayoshi Suzuki, Chemical Science, Vol. 8, No. 9, p. 6400-6408, 2017
  • Hippocampal microRNA-124 enhances chronic stress resilience in mice, Fumihiro Higuchi,Shusaku Uchida,Hirotaka Yamagata,Naoko Abe-Higuchi,Teruyuki Hobara,Kumiko Hara,Ayumi Kobayashi,Tatsushi Shintaku,Yukihiro Itoh,Takayoshi Suzuki,Yoshifumi Watanabe, Journal of Neuroscience, Vol. 36, No. 27, p. 7253-7267, 2016/07/06
  • Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators, Yukihiro Itoh,Keisuke Aihara,Paolo Mellini,Toshifumi Tojo,Yosuke Ota,Hiroki Tsumoto,Viswas Raja Solomon,Peng Zhan,Miki Suzuki,Daisuke Ogasawara,Akira Shigenaga,Tsubasa Inokuma,Hidehiko Nakagawa,Naoki Miyata,Tamio Mizukami,Akira Otaka,Takayoshi Suzuki, Journal of Medicinal Chemistry, Vol. 59, No. 4, p. 1531-1544, 2016/02/25
  • Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide, Taeko Kakizawa,Tamio Mizukami,Yukihiro Itoh,Makoto Hasegawa,Ryuzo Sasaki,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry Letters, Vol. 26, No. 4, p. 1193-1195, 2016/02/15
  • Molecular technology for controlling epigenetics: Regulation of histone acetylation and methylation by small molecules, Yukihiro Itoh,Takayoshi Suzuki, Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Vol. 74, No. 5, p. 441-452, 2016
  • False HDAC inhibition by aurone compound, Yukihiro Itoh,Miki Suzuki,Taiji Matsui,Yosuke Ota,Zi Hui,Kazunori Tsubaki,Takayoshi Suzuki, Chemical and Pharmaceutical Bulletin, Vol. 64, No. 8, p. 1124-1128, 2016
  • C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors, Shin Miyamura,Misaho Araki,Yosuke Ota,Yukihiro Itoh,Shusuke Yasuda,Mitsuharu Masuda,Tomoyuki Taniguchi,Yoshihiro Sowa,Toshiyuki Sakai,Takayoshi Suzuki,Kenichiro Itami,Junichiro Yamaguchi, Organic and Biomolecular Chemistry, Vol. 14, No. 36, p. 8576-8585, 2016
  • Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen, Yosuke Ota,Yukihiro Itoh,Asako Kaise,Kiminori Ohta,Yasuyuki Endo,Mitsuharu Masuda,Yoshihiro Sowa,Toshiyuki Sakai,Takayoshi Suzuki, Angewandte Chemie - International Edition, Vol. 55, No. 52, p. 16115-16118, 2016
  • Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators, Peng Zhan,Yukihiro Itoh,Takayoshi Suzuki,Xinyong Liu, Journal of Medicinal Chemistry, Vol. 58, No. 19, p. 7611-7633, 2015/10/08
  • Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells, Yukihiro Itoh,Hideyuki Sawada,Miki Suzuki,Toshifumi Tojo,Ryuzo Sasaki,Makoto Hasegawa,Tamio Mizukami,Takayoshi Suzuki, ACS Medicinal Chemistry Letters, Vol. 6, No. 6, p. 665-670, 2015/06/11
  • Histone H3 peptide based LSD1-selective inhibitors, Taeko Kakizawa,Yosuke Ota,Yukihiro Itoh,Hiroki Tsumoto,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 9, p. 1925-1928, 2015/05/01
  • Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1, Mohammed Naseer Ahmed Khan,Hiroki Tsumoto,Yukihiro Itoh,Yosuke Ota,Miki Suzuki,Daisuke Ogasawara,Hidehiko Nakagawa,Tamio Mizukami,Naoki Miyata,Takayoshi Suzuki, MedChemComm, Vol. 6, No. 3, p. 407-412, 2015/03/01
  • Recent advances in the structure-based rational design of TNKSIs, Peng Zhan,Yu'Ning Song,Yukihiro Itoh,Takayoshi Suzuki,Xinyong Liu, Molecular BioSystems, Vol. 10, No. 11, p. 2783-2799, 2014/11/01
  • Late-stage C-H coupling enables rapid identification of HDAC inhibitors: Synthesis and evaluation of NCH-31 analogues, Hiromi Sekizawa,Kazuma Amaike,Yukihiro Itoh,Takayoshi Suzuki,Kenichiro Itami,Junichiro Yamaguchi, ACS Medicinal Chemistry Letters, Vol. 5, No. 5, p. 582-586, 2014/05/08
  • Identification of novel SIRT2-selective inhibitors using a click chemistry approach, Prima R. Tatum,Hideyuki Sawada,Yosuke Ota,Yukihiro Itoh,Peng Zhan,Naoya Ieda,Hidehiko Nakagawa,Naoki Miyata,Takayoshi Suzuki, Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 8, p. 1871-1874, 2014/04
  • Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors, Takayoshi Suzuki,Nobusuke Muto,Masashige Bando,Yukihiro Itoh,Ayako Masaki,Masaki Ri,Yosuke Ota,Hidehiko Nakagawa,Shinsuke Iida,Katsuhiko Shirahige,Naoki Miyata, ChemMedChem, Vol. 9, No. 3, p. 657-664, 2014/03
  • Target-guided synthesis: Medicinal chemistry strategy to allow target enzymes themselves to synthesize their own inhibitors, Yukihiro Itoh,Naoki Miyata,Takayoshi Suzuki, Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Vol. 72, No. 6, p. 702-716, 2014
  • Synthesis, LSD1 inhibitory activity, and LSD1 Binding model of optically pure lysine-PCPA conjugates, Yukihiro Itoh,Daisuke Ogasawara,Yosuke Ota,Tamio Mizukami,Takayoshi Suzuki, Computational and Structural Biotechnology Journal, Vol. 9, No. 14, 2014
  • Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity, Takayoshi Suzuki,Hiroki Ozasa,Yukihiro Itoh,Peng Zhan,Hideyuki Sawada,Koshiki Mino,Louise Walport,Rei Ohkubo,Akane Kawamura,Masato Yonezawa,Yuichi Tsukada,Anthony Tumber,Hidehiko Nakagawa,Makoto Hasegawa,Ryuzo Sasaki,Tamio Mizukami,Christopher J. Schofield,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 56, No. 18, p. 7222-7231, 2013/09/26
  • Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation, Yuji Matsuya,Yuta Kobayashi,Sayumi Uchida,Yukihiro Itoh,Hideyuki Sawada,Takayoshi Suzuki,Naoki Miyata,Kenji Sugimoto,Naoki Toyooka, Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 17, p. 4907-4910, 2013/09/01
  • Lysine-specific demethylase 1-selective inactivators: Protein-targeted drug delivery mechanism, Daisuke Ogasawara,Yukihiro Itoh,Hiroki Tsumoto,Taeko Kakizawa,Koshiki Mino,Kiyoshi Fukuhara,Hidehiko Nakagawa,Makoto Hasegawa,Ryuzo Sasaki,Tamio Mizukami,Naoki Miyata,Takayoshi Suzuki, Angewandte Chemie - International Edition, Vol. 52, No. 33, p. 8620-8624, 2013/08/12
  • Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly, Takayoshi Suzuki,Yuki Kasuya,Yukihiro Itoh,Yosuke Ota,Peng Zhan,Kaori Asamitsu,Hidehiko Nakagawa,Takashi Okamoto,Naoki Miyata, PLoS ONE, Vol. 8, No. 7, 2013/07/23
  • Small-molecular modulators of cancer-associated epigenetic mechanisms, Yukihiro Itoh,Takayoshi Suzuki,Naoki Miyata, Molecular BioSystems, Vol. 9, No. 5, p. 873-896, 2013/05
  • Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries, Takayoshi Suzuki,Yosuke Ota,Masaki Ri,Masashige Bando,Aogu Gotoh,Yukihiro Itoh,Hiroki Tsumoto,Prima R. Tatum,Tamio Mizukami,Hidehiko Nakagawa,Shinsuke Iida,Ryuzo Ueda,Katsuhiko Shirahige,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 55, No. 22, p. 9562-9575, 2012/11/26
  • Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist, Yukihiro Itoh,Minoru Ishikawa,Risa Kitaguchi,Keiichiro Okuhira,Mikihiko Naito,Yuichi Hashimoto, Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 13, p. 4453-4457, 2012/07/01
  • Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors, Takayoshi Suzuki,Mohammed Naseer Ahmed Khan,Hideyuki Sawada,Erika Imai,Yukihiro Itoh,Katsura Yamatsuta,Natsuko Tokuda,Jun Takeuchi,Takuya Seko,Hidehiko Nakagawa,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 55, No. 12, p. 5760-5773, 2012/06/28
  • Design, synthesis and biological evaluation of nuclear receptor-degradation inducers, Yukihiro Itoh,Risa Kitaguchi,Minoru Ishikawa,Mikihiko Naito,Yuichi Hashimoto, Bioorganic and Medicinal Chemistry, Vol. 19, No. 22, p. 6768-6778, 2011/11/15
  • Development of target protein-selective degradation inducer for protein knockdown, Yukihiro Itoh,Minoru Ishikawa,Risa Kitaguchi,Shinichi Sato,Mikihiko Naito,Yuichi Hashimoto, Bioorganic and Medicinal Chemistry, Vol. 19, No. 10, p. 3229-3241, 2011/05/15
  • Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein, Keiichiro Okuhira,Nobumichi Ohoka,Kimie Sai,Tomoko Nishimaki-Mogami,Yukihiro Itoh,Minoru Ishikawa,Yuichi Hashimoto,Mikihiko Naito, FEBS Letters, Vol. 585, No. 8, p. 1147-1152, 2011/04
  • Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors, Shohei Hamada,Takayoshi Suzuki,Koshiki Mino,Koichi Koseki,Felix Oehme,Ingo Flamme,Hiroki Ozasa,Yukihiro Itoh,Daisuke Ogasawara,Haruka Komaarashi,Aiko Kato,Hiroki Tsumoto,Hidehiko Nakagawa,Makoto Hasegawa,Ryuzo Sasaki,Tamio Mizukami,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 53, No. 15, p. 5629-5638, 2010/08/12
  • Protein knockdown using methyl bestatin-ligand hybrid molecules: Design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins, Yukihiro Itoh,Minoru Ishikawa,Mikihiko Naito,Yuichi Hashimoto, Journal of the American Chemical Society, Vol. 132, No. 16, p. 5820-5826, 2010/04
  • Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors, Shohei Hamada,Tae Dong Kim,Takayoshi Suzuki,Yukihiro Itoh,Hiroki Tsumoto,Hidehiko Nakagawa,Ralf Janknecht,Naoki Miyata, Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 10, p. 2852-2855, 2009/05/15
  • Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists, Takayoshi Suzuki,Sou Ichi Igari,Akira Hirasawa,Mie Hata,Masaji Ishiguro,Hiroki Fujieda,Yukihiro Itoh,Tatsuya Hirano,Hidehiko Nakagawa,Michitaka Ogura,Makoto Makishima,Gozoh Tsujimoto,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 51, No. 23, p. 7640-7644, 2008/12/11
  • Isoform-selective histone deacetylase inhibitors, Yukihiro Itoh,Takayoshi Suzuki,Naoki Miyata, Current Pharmaceutical Design, Vol. 14, No. 6, p. 529-544, 2008/02
  • Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors, Yukihiro Itoh,Takayoshi Suzuki,Akiyasu Kouketsu,Nobuaki Suzuki,Satoko Maeda,Minoru Yoshida,Hidehiko Nakagawa,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 50, No. 22, p. 5425-5438, 2007/11/01
  • Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors, Takayoshi Suzuki,Shinya Hisakawa,Yukihiro Itoh,Nobuaki Suzuki,Katsumasa Takahashi,Masatoshi Kawahata,Kentaro Yamaguchi,Hidehiko Nakagawa,Naoki Miyata, Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 15, p. 4208-4212, 2007/08/01
  • Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor, Takayoshi Suzuki,Shinya Hisakawa,Yukihiro Itoh,Sakiko Maruyama,Mineko Kurotaki,Hidehiko Nakagawa,Naoki Miyata, Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 6, p. 1558-1561, 2007/03/15
  • Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate, Takayoshi Suzuki,Akiyasu Kouketsu,Yukihiro Itoh,Shinya Hisakawa,Satoko Maeda,Minoru Yoshida,Hidehiko Nakagawa,Naoki Miyata, Journal of Medicinal Chemistry, Vol. 49, No. 16, p. 4809-4812, 2006/08/10

Misc.

  • Challenges of young chemists to be global, Toru Komatsu,Yukihiro Itoh, Yakugaku Zasshi, Vol. 139, No. 2, p. 185-186, 2019
  • Chemical biology for pharmaceutical sciences (novel ideas for “drug” discovery), Youhei Sohma,Yukihiro Itoh, Yakugaku Zasshi, Vol. 137, No. 3, p. 281-282, 2017
  • Study of Ligand Binding Selectivity of Histone Deacetylases by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations, Shuichiro Tsukamoto,Yoshitake Sakae,Yukihiro Itoh,Takayoshi Suzuki,Yuko Okamoto, BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 110, No. 3, p. 544A-545A, 2016/02
  • MEDI 150-Design and synthesis of histone deacetylase 6 selective inhibitors, Takayoshi Suzuki,Akiyasu Kouketsu,Yukihiro Itoh,Shinya Hisakawa,Satoko Maeda,Minoru Yoshida,Hidehiko Nakagawa,Naoki Miyata, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, Vol. 232, 2006/09