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Okamoto Tooru

岡本 徹

Institute for Advanced Co-Creation Studies, Professor

Research Areas

  • Life sciences, Virology

Papers

  • Hepatitis C virus modulates signal peptide peptidase to alter host protein processing., Junki Hirano,Sachiyo Yoshio,Yusuke Sakai,Li Songling,Tatsuya Suzuki,Yumi Itoh,He Zhang,David Virya Chen,Saori Haga,Hiroko Oomori,Takahiro Kodama,Yusuke Maeda,Yoshihiro Ono,Yu Takahashi,Daron M Standley,Masahiro Yamamoto,Kohji Moriishi,Kyoji Moriya,Tatsuya Kanto,Tetsuo Takehara,Kazuhiko Koike,Yoshiharu Matsuura,Toru Okamoto, Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 22, 2021/06/01
  • Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2., Michael J Roy,Amelia Vom,Toru Okamoto,Brian J Smith,Richard W Birkinshaw,Hong Yang,Houda Abdo,Christine A White,David Segal,David C S Huang,Jonathan B Baell,Peter M Colman,Peter E Czabotar,Guillaume Lessene, Journal of medicinal chemistry, Vol. 64, No. 9, p. 5447-5469, 2021/05/13
  • Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct-acting antivirals., Satoru Joshita,Yuki Yamashita,Toru Okamoto,Yoko Usami,Ayumi Sugiura,Tomoo Yamazaki,Akemi Kakino,Masao Ota,Tatsuya Sawamura,Takeji Umemura, Hepatology research : the official journal of the Japan Society of Hepatology, 2021/05/13
  • Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1., Aya Nakae,Michiko Kodama,Toru Okamoto,Makoto Tokunaga,Hiroko Shimura,Kae Hashimoto,Kenjiro Sawada,Takahiro Kodama,Neal G Copeland,Nancy A Jenkins,Tadashi Kimura, Biochemical and biophysical research communications, Vol. 552, p. 120-127, 2021/05/07
  • Deneddylation by SENP8 restricts hepatitis B virus propagation, David Virya Chen,Tatsuya Suzuki,Yumi Itoh,Yusuke Maeda,Junki Hirano,Saori Haga,He Zhang,Daiki Ito,Yoshiharu Matsuura,Toru Okamoto, Microbiology and Immunology, Vol. 65, No. 3, p. 125-135, 2021/03
  • Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation, Yuzy Fauzyah,Chikako Ono,Shiho Torii,Itsuki Anzai,Rigel Suzuki,Takuma Izumi,Yuhei Morioka,Yusuke Maeda,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matsuura, Antiviral Research, Vol. 186, 2021/02
  • MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex, Tirta Mario Djajawi,Lei Liu,Jia nan Gong,Allan Shuai Huang,Ming jie Luo,Zhen Xu,Toru Okamoto,Melissa J. Call,David C.S. Huang,Mark F. van Delft, Cell Death and Differentiation, Vol. 27, No. 8, p. 2484-2499, 2020/08/01
  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis, Kiyoharu Fukushima,Takashi Satoh,Fuminori Sugihara,Yuki Sato,Toru Okamoto,Yuichi Mitsui,Sachiyo Yoshio,Songling Li,Satoshi Nojima,Daisuke Motooka,Shota Nakamura,Hiroshi Kida,Daron M. Standley,Eiichi Morii,Tatsuya Kanto,Motoko Yanagita,Yoshiharu Matsuura,Takashi Nagasawa,Atsushi Kumanogoh,Shizuo Akira, Immunity, Vol. 52, No. 3, p. 542-556.e13, 2020/03/17
  • Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein, Makoto Tokunaga,Yoichi Miyamoto,Tatsuya Suzuki,Mayumi Otani,Shinsuke Inuki,Tsuyoshi Esaki,Chioko Nagao,Kenji Mizuguchi,Hiroaki Ohno,Yoshihiro Yoneda,Toru Okamoto,Masahiro Oka,Yoshiharu Matsuura, Virology, Vol. 541, p. 41-51, 2020/02
  • Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma, Yohei Mano,Sachiyo Yoshio,Hirotaka Shoji,Shimagaki Tomonari,Yoshihiko Aoki,Nobuyoshi Aoyanagi,Toru Okamoto,Yoshiharu Matsuura,Yosuke Osawa,Kiminori Kimura,Kyohei Yugawa,Huanlin Wang,Yoshinao Oda,Tomoharu Yoshizumi,Yoshihiko Maehara,Tatsuya Kanto, Journal of Gastroenterology, Vol. 54, No. 11, p. 1007-1018, 2019/11/01
  • In vivo dynamics of reporter flaviviridae viruses, Tomokazu Tamura,Manabu Igarashi,Bazarragchaa Enkhbold,Tatsuya Suzuki,Masatoshi Okamatsu,Chikako Ono,Hiroyuki Mori,Takuma Izumi,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Yoshihiro Sakoda,Takasuke Fukuhara,Yoshiharu Matsuura, Journal of Virology, Vol. 93, No. 22, 2019/11/01
  • CXCR4 regulates Plasmodium development in mouse and human hepatocytes, Hironori Bando,Ariel Pradipta,Shiroh Iwanaga,Toru Okamoto,Daisuke Okuzaki,Shun Tanaka,Joel Vega-Rodríguez,Youngae Lee,Ji Su Ma,Naoya Sakaguchi,Akira Soga,Shinya Fukumoto,Miwa Sasai,Yoshiharu Matsuura,Masao Yuda,Marcelo Jacobs-Lorena,Masahiro Yamamoto, Journal of Experimental Medicine, Vol. 216, No. 8, p. 1733-1748, 2019/08/01
  • Peroxiredoxin 1, a novel HBX-interacting protein, interacts with exosome component 5 and negatively regulates hepatitis B virus (HBV) propagation through degradation of HBV RNA, Lin Deng,Xiang Gan,Masahiko Ito,Ming Chen,Hussein H. Aly,Chieko Matsui,Takayuki Abe,Koichi Watashi,Takaji Wakita,Tetsuro Suzuki,Toru Okamoto,Yoshiharu Matsuura,Masashi Mizokami,Ikuo Shoji,Hak Hotta, Journal of Virology, Vol. 93, No. 6, 2019/03/01
  • USP15 participates in hepatitis C virus propagation through regulation of viral RNA translation and lipid droplet formation, Shinji Kusakabe,Tatsuya Suzuki,Yukari Sugiyama,Saori Haga,Kanako Horike,Makoto Tokunaga,Junki Hirano,He Zhang,David Virya Chen,Hanako Ishiga,Yasumasa Komoda,Chikako Ono,Takasuke Fukuhara,Masahiro Yamamoto,Masahito Ikawa,Takashi Satoh,Shizuo Akira,Tomohisa Tanaka,Kohji Moriishi,Moto Fukai,Akinobu Taketomi,Sachiyo Yoshio,Tatsuya Kanto,Tetsuro Suzuki,Toru Okamoto,Yoshiharu Matsuura, Journal of Virology, Vol. 93, No. 6, 2019/03/01
  • Induction of selective autophagy in cells replicating hepatitis C virus genome, Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Asuka Sato,Yuzy Fauzyah,Masami Wada,Toru Okamoto,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, Journal of General Virology, Vol. 99, No. 12, p. 1643-1657, 2018/12
  • Baculovirus as a tool for gene delivery and gene therapy, Chikako Ono,Toru Okamoto,Takayuki Abe,Yoshiharu Matsuura, Viruses, Vol. 10, No. 9, 2018/09/19
  • St6gal1 knockdown alters HBV life cycle in HepAD38 cells, Surya Agung Priyambada,Ryo Misaki,Toru Okamoto,Takao Ohashi,Keiji Ueda,Yoshiharu Matsuura,Kazuhito Fujiyama, Biochemical and Biophysical Research Communications, Vol. 503, No. 3, p. 1841-1847, 2018/09/10
  • Infection with flaviviruses requires BCLX<inf>L</inf> for cell survival, Tatsuya Suzuki,Toru Okamoto,Hiroshi Katoh,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Yuka Miyata,Takasuke Fukuhara,Masahito Ikawa,Takashi Satoh,Sachiyo Yoshio,Ryosuke Suzuki,Masayuki Saijo,David C.S. Huang,Tatsuya Kanto,Shizuo Akira,Yoshiharu Matsuura, PLoS Pathogens, Vol. 14, No. 9, 2018/09
  • Novel miRNA biomarkers for genotoxicity screening in mouse, Hiroyuki Oka,Koichi Masuno,Takeki Uehara,Toru Okamoto,Yoshiharu Matsuura,Toru Nakano,Shinpei Yamaguchi, Toxicology, Elsevier Ireland Ltd, Vol. 404-405, p. 68-75, 2018/07/01
  • Evaluation of viral contamination in a baculovirus expression system, Chikako Ono,Junki Hirano,Toru Okamoto,Yoshiharu Matsuura, Microbiology and Immunology, Blackwell Publishing Asia, Vol. 62, No. 3, p. 200-204, 2018/03
  • Characterization of recombinant Flaviviridae viruses possessing a small reporter Tag, Tomokazu Tamura,Takasuke Fukuhara,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Takeshi Kurosu,Yin Xiang Setoh,Michio Imamura,Norbert Tautz,Yoshihiro Sakoda,Alexander A. Khromykh,Kazuaki Chayama,Yoshiharu Matsuura, Journal of Virology, American Society for Microbiology, Vol. 92, No. 2, 2018/01/01
  • Characterization of SPP inhibitors suppressing propagation of HCV and protozoa, Junki Hirano,Toru Okamoto,Yukari Sugiyama,Tatsuya Suzuki,Shinji Kusakabe,Makoto Tokunaga,Takasuke Fukuhara,Miwa Sasai,Takahiro Tougan,Yasue Matsunaga,Kazuo Yamashita,Yusuke Sakai,Masahiro Yamamoto,Toshihiro Horii,Daron M. Standley,Kohji Moriishi,Kyoji Moriya,Kazuhiko Koike,Yoshiharu Matsuura, Proceedings of the National Academy of Sciences of the United States of America, NATL ACAD SCIENCES, Vol. 114, No. 50, p. E10782-E10791, 2017/12/12
  • Suppression of HBV replication by the expression of nickase-and nuclease dead-Cas9, Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masaya Sugiyama,Daisuke Motooka,Shota Nakamura,Masato Ikawa,Masashi Mizokami,Yoshihiko Maehara,Yoshiharu Matsuura, Scientific Reports, NATURE PUBLISHING GROUP, Vol. 7, No. 1, 2017/12/01
  • Semagacestat Is a Pseudo-Inhibitor of γ-Secretase, Shinji Tagami,Kanta Yanagida,Takashi S. Kodama,Mako Takami,Naoki Mizuta,Hiroshi Oyama,Kouhei Nishitomi,Yu wen Chiu,Toru Okamoto,Takeshi Ikeuchi,Gaku Sakaguchi,Takashi Kudo,Yoshiharu Matsuura,Akio Fukumori,Masatoshi Takeda,Yasuo Ihara,Masayasu Okochi, Cell Reports, CELL PRESS, Vol. 21, No. 1, p. 259-273, 2017/10/03
  • Semagacestat Is a Pseudo-Inhibitor of γ-Secretase, Shinji Tagami,Kanta Yanagida,Takashi S. Kodama,Mako Takami,Naoki Mizuta,Hiroshi Oyama,Kouhei Nishitomi,Yu wen Chiu,Toru Okamoto,Takeshi Ikeuchi,Gaku Sakaguchi,Takashi Kudo,Yoshiharu Matsuura,Akio Fukumori,Masatoshi Takeda,Yasuo Ihara,Masayasu Okochi, Cell Reports, CELL PRESS, Vol. 21, No. 1, p. 259-273, 2017/10/03
  • Importin-independent nuclear translocation of flavivirus core proteins, Makoto Tokunaga,Toru Okamoto,Yoichi Miyamoto,Takasuke Fukuhara,Yoshiharu Matsuura, 2017/10
  • A deubiquitinating enzyme USP15 participates in the propagation of HCV through the regulation of lipid metabolism, Shinji Kusakabe,Toru Okamoto,Yukari Sugiyama,Takasuke Fukuhara,Kazuhiko Koike,Yoshiharu Matsuura, 2017/10
  • Characterization of selective autophagy induced by HCV RNA replication, Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Asuka Sato,Yuzy Fauzyah,Shinya Yamada,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, 2017/10
  • BCLXL dependent survivals upon infection with Flaviviruses, Tatsuya Suzuki,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura, 2017/10
  • Engineering of small reporter-tagged Flaviviridae viruses applicable to antiviral screening and in vivo dynamics, Tomokazu Tamura,Takasuke Fukuhara,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Kazuaki Chayama,Yoshiharu Matsuura, 2017/10
  • Involvement of other miRNA on the propagation of HCV in miR-1-deficient cells, Chikako Ono,Takasuke Fukuhara,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Kazuaki Chayama,Kazuhiko Koike,Yoshiharu Matsuura, 2017/10
  • The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses, Michihiro Takahama,Mitsunori Fukuda,Norihiko Ohbayashi,Tatsuya Kozaki,Takuma Misawa,Toru Okamoto,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh, Cell Reports, CELL PRESS, Vol. 20, No. 12, p. 2944-2954, 2017/09/19
  • Engineering of Small Reporter-Tagged Flaviviridae Viruses Applicable to Antiviral Screening and in vivo Dynamics, Tomokazu Tamura,Takasuke Fukuhara,Akatuski Saito,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Tatuso Shioda,Kazuaki Chayama,Yoshiharu Matsuura, 2017/09
  • Viral secretory glycoproteins of Pestivirus and Flavivirus have similar roles with exchangeable apolipoproteins on the formation of infectious HCV particles, Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Asuka Sato,Shinya Yamada,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, 2017/09
  • Selective TLR ligands stimulated pathogenicity of JEV infection in vivo, Yuka Miyata,Tatsuya Suzuki,Toru Okamoto,Yoshiharu Matsuura, 2017/09
  • Importin-independent nuclear translocation of flavivirus core proteins, Makoto Tokunaga,Toru Okamoto,Yoichi Miyamoto,Takasuke Fukuhara,Yoshiharu Matsuura, 2017/09
  • A deubiquitinating enzyme USP15 participates in the propagation of HCV through the regulation of lipid metabolism, Shinji Kusakabe,Toru Okamoto,Yukari Sugiyama,Takasuke Fukuhara,Kazuhiko Koike,Yoshiharu Matsuura, 2017/09
  • cterization of selective autophagy induced by infection with hepatitis C virus, Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Asuka Sato,Yuzy Fauzyah,Masami Wada,Toru Okamoto,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, 2017/09
  • BCLXL participates in pathogenicity of flavivirus infection, Tatsuya Suzuki,Yukari Sugiyama,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura, 2017/09
  • Characterization of recombinant Flaviviridae viruses possessing a small reporter-tag, Tomokazu Tamura,Takasuke Fukuhara,Takuro Uchida,Chikako Ono,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Kazuaki Chayama,Yoshiharu Matsuura, 2017/09
  • Regulation of apoptosis during flavivirus infection, Toru Okamoto,Tatsuya Suzuki,Shinji Kusakabe,Makoto Tokunaga,Junki Hirano,Yuka Miyata,Yoshiharu Matsuura, Viruses, MDPI AG, Vol. 9, No. 9, 2017/09
  • Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus, Surya Agung Priyambada,Ryo Misaki,Toru Okamoto,Yuta Okamoto,Takao Ohashi,Keiji Ueda,Yoshiharu Matsuura,Kazuhito Fujiyama, Virus Research, ELSEVIER SCIENCE BV, Vol. 238, p. 101-109, 2017/06/15
  • Roles of miR-574-5p and miR-504-3p on the propagation of HCV in miR-122-deficient cells, Chikako Ono,Takasuke Fukuhara,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Yuzy Fauzyah,Toru Okamoto,Kazuhiko Koike,Yoshiharu Matsuura, 2017/06
  • Characterization of Flaviviridae viruses possessing a reporter gene, Tomokazu Tamura,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Takeshi Kurosu,Norbert Tautz,Yoshihiro Sakoda,Yoshiharu Matsuura, 2017/06
  • Characterization of selective autophagy induced by HCV RNA replication, Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Kentaro Uemura,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, 2017/06
  • BCLXL dependent survivals upon infection with Flaviviruses, Tatsuya Suzuki,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matsuura, 2017/06
  • Host-derived apolipoproteins play comparable roles with viral secretory proteins E-rns and NS1 in the infectious particle formation of Flaviviridae, Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Mai Shiokawa,Hiroyuki Mori,Kentaro Uemura,Satomi Yamamoto,Takeshi Kurihara,Toru Okamoto,Ryosuke Suzuki,Kentaro Yoshii,Takeshi Kurosu,Manabu Igarashi,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 13, No. 6, 2017/06
  • Characterization of miR-122-independent propagation of HCV, Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Daisuke Okuzaki,Satomi Yamamoto,Tomokazu Tamura,Hiroyuki Mori,Asuka Sato,Kentaro Uemura,Yuzy Fauzyah,Takeshi Kurihara,Takahiro Suda,Akira Nishio,Su Su Hmwe,Toru Okamoto,Tomohide Tatsumi,Tetsuo Takehara,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, PLoS Pathogens, PUBLIC LIBRARY SCIENCE, Vol. 13, No. 5, 2017/05
  • JMJD5 regulates HBV replication through interaction with HBx, Toru Okamoto,Kazuo Yamashita,Tatsuya Suzuki,Shinji Kusakabe,Junki Hirano,Takasuke Fukuhara,Atsuya Yamashita,Kazunobu Saito,Daisue Okuzaki,Daron M Stanley,Khoji Moriishi,Yoshiharu Matsuura, 2017/04
  • Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity, Takasuke Fukuhara,Satomi Yamamoto,Chikako Ono,Shota Nakamura,Daisuke Motooka,Hiroyuki Mori,Takeshi Kurihara,Asuka Sato,Tomokazu Tamura,Takashi Motomura,Toru Okamoto,Michio Imamura,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Yoshihiko Maehara,Kazuaki Chayama,Yoshiharu Matsuura, Scientific Reports, NATURE PUBLISHING GROUP, Vol. 7, 2017/03/22
  • C型肝炎ウイルスの増殖と病原性に関与する宿主因子, Yoshiharu Matsuura,Takasuke Fukuhara,Toru Okamoto, 2017/03
  • Extensive Ca<sup>2+</sup> leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca<sup>2+</sup> hypersensitivity, Akira Uehara,Takashi Murayama,Midori Yasukochi,Michael Fill,Minoru Horie,Toru Okamoto,Yoshiharu Matsuura,Kiyoko Uehara,Takahiro Fujimoto,Takashi Sakurai,Nagomi Kurebayashi, Journal of General Physiology, ROCKEFELLER UNIV PRESS, Vol. 149, No. 2, p. 199-218, 2017
  • Host-derived apolipoproteins play comparable roles with viral secretory proteins E<sup>rns</sup>and NS1 in the infectious particle formation of Flaviviridae, Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Mai Shiokawa,Hiroyuki Mori,Kentaro Uemura,Satomi Yamamoto,Takeshi Kurihara,Toru Okamoto,Ryosuke Suzuki,Kentaro Yoshii,Takeshi Kurosu,Manabu Igarashi,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, PLoS Pathogens, Public Library of Science, Vol. 13, No. 6, 2017
  • Signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus, Yoshiharu Matsuura,Toru Okamoto, 2016/10
  • CDK9 inhibitor FIT-039 suppresses HBV propagation, Kohji Moriishi,Tomohisa Tanaka,Kaori Okuyama-obashi,Wenjia Chen,Toru Okamoto,Keiji Ueda,Takamitsu Hosoya,Yoshiharu Matsuura,Akihide Ryo,Yasuhito Tanaka,Masatoshi Hagiwara, 2016/10
  • Non-canonical LC3 lipidation induced by hepatitis C virus inhibits autophagic flux, Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, 2016/10
  • Human cathelicidin can compensate the role of apolipoproteins in the formation of infectious HCV particles, Tomokazu Tamura,Francesc Puig-Basagoiti,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Yoshiharu Matsuura, 2016/10
  • G28A mutation is necessary for an efficient propagation of HCV in miR-122 deficient condition, Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Satomi Yamamoto,Hiroyuki Mori,Kentaro Uemura,Toru Okamoto,Su Su Hmwe,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, 2016/10
  • フラビウイルス科ウイルスの粒子産生における分泌性糖タンパク質の役割, Tomokazu Tamura,Takasuke Fukuhara,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, 2016/10
  • Evaluation of γ-secretase inhibitors for HCV therapy, Junki Hirano,Yukari Sugiyama,Tatsuya Suzuki,Shinji Kusakabe,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura, 2016/10
  • Host factors participate in innate immune response upon infection with hepatitis B virus, Kentaro Uemura,Chikako Ono,Takasuke Fukuhara,Toru Okamoto,Yoshiharu Matsuura, 2016/10
  • Glycine 135 of JMJD5 is involved in the interaction with HBx, Shinji Kusakabe,Takahisa Kouwaki,Yukari Sugiyama,Tatsuya Suzuki,Junki Hirano,Takasuke Fukuhara,Masaya Sugiyama,Masashi Mizokami,Toru Okamoto,Yoshiharu Matsuura, 2016/10
  • Non-canonical LC3 lipidation induced by HCV inhibits autophagic flux, Hiroyuki Mori,Takasuke Fukuhara,Chikako Ono,Tomokazu Tamura,Satomi Yamamoto,Kentaro Uemura,Toru Okamoto,Masami Wada,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, 2016/10
  • Regulation of Bcl-2 family proteins in cells infected with Flaviviruses, Tatsuya Suzuki,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matusuura, 2016/10
  • Double nicking by Cas9-Nickase with pair sgRNAs cleaves HBV genome, Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Tomokazu Tamura,Toru Okamoto,Yoshiharu Matsuura, 2016/10
  • The roles of secretory glycoproteins in viral particle formation in family Flaviviridae, Tomokazu Tamura,Takasuke Fukuhara,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, 2016/10
  • G28A mutation facilitates an efficient propagation of HCV in miR-122-independent manner, Chikako Ono,Takasuke Fukuhara,Daisuke Motooka,Shota Nakamura,Satomi Yamamoto,Hiroyuki Mori,Kentaro Uemura,Toru Okamoto,Su Su Hmwe,Kazuaki Chayama,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, 2016/10
  • Regulation of Bcl-2 family proteins in cells infected with Flaviviruses, Toru Okamoto,Tatsuya Suzuki,Shinji Kusakabe,Junki Hirano,Makoto Tokunaga,Takasuke Fukuhara,Yoshiharu Matsuura, 2016/10
  • Single peptide peptidase a target for anti-HCV drug, Toru Okamoto,Junki Hirano,Tatsuya Suzuki,Shinji Kusakabe,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matsuura, 2016/10
  • Viral secretory glycoproteins of Flaviviridae virus have similar roles with apolipoproteins on the formation of infectious HCV particles, Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Kentaro Uemura,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, 2016/10
  • Analysis of the HBV life cycle in a HepG2 expressing human NTCP, Retno Rahayu,Eriko Ohsaki,Toru Okamoto,Koichi Watash,Keiji Ueda, 2016/10
  • Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation, Tomohisa Tanaka,Kaori Okuyama-Dobashi,Shuko Murakami,Wenjia Chen,Toru Okamoto,Keiji Ueda,Takamitsu Hosoya,Yoshiharu Matsuura,Akihide Ryo,Yasuhito Tanaka,Masatoshi Hagiwara,Kohji Moriishi, Antiviral Research, ELSEVIER SCIENCE BV, Vol. 133, p. 156-164, 2016/09/01
  • CHARACTERIZATION OF MIR-122-INDEPENDENT PROPAGATION OF HCV, Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Hiroyuki Mori,Kentaro Uemura,Yukako Kawachi,Toru Okamoto,Su Su Hmwe,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, 2016/06
  • REGULATION OF BCL-2 FAMILY PROTEINS IN CELLS INFECTED WITH VIRUSES OF THE FAMILY FLAVIVIRIDAE, Tatsuya Suzuki,Toru Okamoto,Takasuke Fukuhara,Yoshiharu Matsuura, 2016/06
  • HUMAN CATHELICIDIN CAN COMPENSATE THE ROLE OF APOLIPOPROTEINS IN THE FORMATION OF INFECTIOUS HCV PARTICLES, Tomokazu Tamura,Francesc Puig-Basagoiti,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Yoshiharu Matsuura, 2016/06
  • VLDLR HAS A REDUNDANT ROLE WITH SR-B1 AND LDLR IN THE ENTRY OF LIPIDASSOCIATED HCV, Takasuke Fukuhara,Satomi Yamamoto,Chikako Ono,Tomokazu Tamura,Hiroyuki Mori,Yukako Kawachi,Kentaro Uemura,Toru Okamoto,Yoshiharu Matsuura, 2016/06
  • TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis, Sayaka Aizawa,Toru Okamoto,Yukari Sugiyama,Takahisa Kouwaki,Ayano Ito,Tatsuya Suzuki,Chikako Ono,Takasuke Fukuhara,Masahiro Yamamoto,Masayasu Okochi,Nobuhiko Hiraga,Michio Imamura,Kazuaki Chayama,Ryosuke Suzuki,Ikuo Shoji,Kohji Moriishi,Kyoji Moriya,Kazuhiko Koike,Yoshiharu Matsuura, Nature Communications, NATURE PUBLISHING GROUP, Vol. 7, 2016/05/04
  • Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus, Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Kentaro Uemura,Yukako Kawachi,Mai Shiokawa,Hiroyuki Mori,Masami Wada,Ryoichi Shima,Toru Okamoto,Nobuhiko Hiraga,Ryosuke Suzuki,Kazuaki Chayama,Takaji Wakita,Yoshiharu Matsuura, PLoS Pathogens, PUBLIC LIBRARY SCIENCE, Vol. 12, No. 5, 2016/05
  • Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA, Masuda, K,Ripley, B,Nyati, K,Dubey, P,Zaman, M,Hanieh, H,Hoga, M,Yamashita, K,Standley, D,Mashima, T,Katahira, M,Okamoto, T,Matsuura, Y,Takeuchi, O,Kishimoto, T, The Journal of experimental medicine, Vol. 213, No. 4, p. 605-619, 2016/04/04
  • Arid5a regulates naive CD4<sup>+</sup> T cell fate through selective stabilization of Stat3 mRNA, Kazuya Masuda,Barry Ripley,Kishan Kumar Nyati,Praveen Kumar Dubey,Mohammad Mahabub Uz Zaman,Hamza Hanieh,Mitsuru Higa,Kazuo Yamashita,Daron M. Standley,Tsukasa Mashima,Masato Katahira,Toru Okamoto,Yoshiharu Matsuura,Osamu Takeuchi,Tadamitsu Kishimoto, Journal of Experimental Medicine, ROCKEFELLER UNIV PRESS, Vol. 213, No. 4, p. 605-619, 2016/04
  • Production of hepatitis E virus-like particles presenting multiple foreign epitopes by co-infection of recombinant baculoviruses, Ryoichi Shima,Tian Cheng Li,Yutaka Sendai,Chikako Kataoka,Yoshio Mori,Takayuki Abe,Naokazu Takeda,Toru Okamoto,Yoshiharu Matsuura, Scientific Reports, NATURE PUBLISHING GROUP, Vol. 6, 2016/02/24
  • Human cathelicidin compensates for the role of apolipoproteins in hepatitis C virus infectious particle formation, Francesc Puig-Basagoiti,Takasuke Fukuhara,Tomokazu Tamura,Chikako Ono,Kentaro Uemura,Yukako Kawachi,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hideki Aizaki,Yoshiharu Matsuura, Journal of Virology, AMER SOC MICROBIOLOGY, Vol. 90, No. 19, p. 8464-8477, 2016
  • Roles of lipoprotein receptors in the entry of hepatitis C virus, Takasuke Fukuhara,Satomi Yamamoto,Chikako Ono,Hiroyuki Mori,Francesc Puig-Basagoiti,Toru Okamoto,Yoshiharu Matsuura, 2016/01
  • Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B, Sachiyo Yoshio,Masaya Sugiyama,Hirotaka Shoji,Yohei Mano,Eiji Mita,Toru Okamoto,Yoshiharu Matsuura,Alato Okuno,Osamu Takikawa,Masashi Mizokami,Tatsuya Kanto, Hepatology, WILEY-BLACKWELL, Vol. 63, No. 1, p. 83-94, 2016/01/01
  • Hepatocyte factor JMJD5 regulates hepatitis B virus replication through interaction with HBx, Takahisa Kouwaki,Toru Okamoto,Ayano Ito,Yukari Sugiyama,Kazuo Yamashita,Tatsuya Suzuki,Shinji Kusakabe,Junki Hirano,Takasuke Fukuhara,Atsuya Yamashita,Kazunobu Saito,Daisuke Okuzaki,Koichi Watashi,Masaya Sugiyama,Sachiyo Yoshio,Daron M. Standley,Tatsuya Kanto,Masashi Mizokami,Kohji Moriishi,Yoshiharu Matsuura, Journal of Virology, AMER SOC MICROBIOLOGY, Vol. 90, No. 7, p. 3530-3542, 2016
  • Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide, Kaori Okuyama-Dobashi,Hirotake Kasai,Tomohisa Tanaka,Atsuya Yamashita,Jun Yasumoto,Wenjia Chen,Toru Okamoto,Shinya Maekawa,Koichi Watashi,Takaji Wakita,Akihide Ryo,Tetsuro Suzuki,Yoshiharu Matsuura,Nobuyuki Enomoto,Kohji Moriishi, Scientific Reports, NATURE PUBLISHING GROUP, Vol. 5, 2015/11/23
  • Involvement of FKBP6 in hepatitis C virus replication, Hirotake Kasai,Kunihiro Kawakami,Hiromasa Yokoe,Kentaro Yoshimura,Masanori Matsuda,Jun Yasumoto,Shinya Maekawa,Atsuya Yamashita,Tomohisa Tanaka,Masanori Ikeda,Nobuyuki Kato,Toru Okamoto,Yoshiharu Matsuura,Naoya Sakamoto,Nobuyuki Enomoto,Sen Takeda,Hideki Fujii,Masayoshi Tsubuki,Masami Kusunoki,Kohji Moriishi, Scientific Reports, NATURE PUBLISHING GROUP, Vol. 5, 2015/11/16
  • TRC8-dependent proteasome degradation of immature core protein participates in pathogenesis of HCV, Toru Okamoto,Yukari Sugiyama,Takahisa Kouwaki,Ayano Ito,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura, 2015/11
  • Human cathelicidin (hCAP18/LL37) can compensate the role of apolipoproteins in the formation of infectious HCV particles, Puig-Basagoiti Francesc,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takshi Kurihara,Toru Okamoto,Yoshiharu Matsuura, 2015/11
  • Apolipoproteins and viral secretory glycoproteins participate in the infectious particle formation of Flaviviridae, Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, 2015/11
  • Roles of lipoprotein receptors in the lifecycle of HCV, Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Takeshi Kurihara,Francesc Puig-Basagoiti,Toru Okamoto,Yoshiharu Matsuura, 2015/11
  • Suppression of hepatitis B virus replication by CRISPR/Cas9 system, Takeshi Kurihara,Takasuke Fukuhara,Chikako Ono,Hiroyuki Mori,Satomi Yamamoto,Takahisa Kohwaki,Toru Okamoto,Yoshiharu Matsuura, 2015/11
  • Characterization of miR-122-independent propagation of HCV, Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Hiroyuki Mori,Toru Okamoto,Su Su Hmwe,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, 2015/11
  • フラビウイルス科に共通した小胞体膜結合因子を介した粒子産生機構の解析, 福原 崇介,田村 友和,塩川 舞,小野 慎子,山本 聡美,森 寛行,栗原 健,岡本 徹,青木 博史,迫田 義博,松浦 善治, 2015/11
  • Host or virus derived secretory membrane binding proteins are involved in formation of infectious Flavivirus particles, Takasuke Fukuhara,Tomokazu Tamura,Mai Shiokawa,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Takeshi Kurihara,Puig-Basagoiti Francesc,Toru Okamoto,Hiroshi Aoki,Yoshihiro Sakoda,Yoshiharu Matsuura, 2015/11
  • Regulation of Bcl-2 family proteins in cells infected with Flaviviruses, Tatsuya Suzuki,Toru Okamoto,Hiroshi Katoh,Takasuke Fukuhara,Yoshiharu Matsuura, 2015/11
  • Characterization of miR-122-independent propagation of HCV, Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Hiroyuki Mori,Toru Okamoto,Su Su Hmwe,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, 2015/10
  • TRC8-dependent proteasome degradation of immature core protein participates in pathogenesis of HCV, Toru Okamoto,Yukari Sugiyama,Takahisa Kouwaki,Ayano Ito,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura, 2015/10
  • Signal peptide peptidase regulates propagation and pathogenesis of Hepatitis C Virus, Toru Okamoto,Yukari Sugiyama,Ayano Ito,Takasuke Fukuhara,Yoshiharu Matusuura, 2015/09
  • HCV Infection Inhibits Autophagy through Lipidation of LC3, Takasuke Fukuhara,Masami Wada,Chikako Ono,Satomi Yamamoto,Hiroyuki Mori,Toru Okamoto,Takeshi Noda,Tamotsu Yoshimori,Yoshiharu Matsuura, 2015/07
  • Roles of Lipoprotein Receptors in the Lifecycle of Hepatitis C Virus, Satomi Yamamoto,Takasuke Fukuhara,Chikako Ono,Mai Shiokawa,Masami Wada,Toru Okamoto,Yoshiharu Matsuura, 2015/07
  • JMJD5 regulates HBV replication through the interaction with HBx., Takahisa Kouwaki,Toru Okamoto,Ayano Ito,Takasuke Fukuhara,Masaya Sugiyama,Masashi Mizokami,Yoshiharu Matsuura, 2015/07
  • Processing of core protein by signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus, Toru Okamoto,Sayaka Aizawa,Yukari Sugiyama,Takahisa Kouwaki,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura, 2015/07
  • Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin, Koji Matsuhisa,Seiji Yamane,Toru Okamoto,Akihiro Watari,Masuo Kondoh,Yoshiharu Matsuura,Kiyohito Yagi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 462, No. 1, p. 52-57, 2015/06
  • Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin, Koji Matsuhisa,Seiji Yamane,Toru Okamoto,Akihiro Watari,Masuo Kondoh,Yoshiharu Matsuura,Kiyohito Yagi, Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 462, No. 1, p. 52-57, 2015/05/28
  • ゲノム編集技術を用いたHCVコアタンパク質の機能解析, 岡本徹,相澤清香,杉山由加理,幸脇貴久,伊藤彩乃,鈴木達也,福原崇介,森石恆司,小池和彦,松浦善治, 2015/05
  • Processing of core protein by signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus, Toru Okamoto,Sayaka Aizawa,Takahisa Kouwaki,Tatsuya Suzuki,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura, 2015/04
  • Host factors involved in the propagation and pathogenesis of hepatitis C Virus, Toru Okamoto,Yoshiharu Matsuura, Inflammation and Immunity in Cancer, p. 103-108, 2015/01/01
  • Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles, Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Mai Shiokawa,Satomi Yamamoto,Takashi Motomura,Toru Okamoto,Daisuke Okuzaki,Masahiro Yamamoto,Izumu Saito,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, PLoS Pathogens, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 12, 2014/12/01
  • Amphipathic alpha-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles, Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Mai Shiokawa,Satomi Yamamoto,Takashi Motomura,Toru Okamoto,Daisuke Okuzaki,Masahiro Yamamoto,Izumu Saito,Takaji Wakita,Kazuhiko Koike,Yoshiharu Matsuura, PLOS PATHOGENS, PUBLIC LIBRARY SCIENCE, Vol. 10, No. 12, 2014/12
  • HBx結合タンパク質JMJD5の同定と機能解析, 幸脇貴久,岡本徹,相澤清香,杉山由加理,福原崇介,杉山真也,溝上雅史,松浦善治, 2014/11
  • Processing of core protein by signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus, Sayaka Aizawa,Toru Okamoto,Takahisa Kouwaki,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matusuura, 2014/11
  • Host factors involved in HBV propagation and pathogenesis, Toru Okamoto,Takahisa Kouwaki,Ayano Ito,Takasuke Fukuhara,Yoshiharu Matsuura, 2014/11
  • バキュロウイルスによる哺乳動物細胞での遺伝子発現は自然免疫応答によって抑制される, 小野慎子,山本聡美,二宮彰紀,阿部隆之,福原崇介,岡本徹,松浦善治, 2014/11
  • 遺伝子組換え酵母由来B型肝炎ウイルス様粒子の細胞表面への結合に関与する宿主因子の解析, 松田麻未,鈴木亮介,嵯峨涼平,藤本陽,渡士幸一,相崎英樹,森石恆司,岡本徹,松浦善治,黒田俊一,脇田隆字, 2014/11
  • トリプシン・EDTAによるNTCP依存HBV感染の増強, 土橋香織,葛西宏威,田中智久,陳文家,渡士幸一,脇田隆字,山下篤哉,梁明秀,岡本徹,松浦善治,森石恆司, 2014/11
  • HCVのQuasispeciesは増殖性に関与する, 福原崇介,山本聡美,小野慎子,和田真実,岡本徹,茶山一彰,松浦善治, 2014/11
  • C型肝炎ウイルスの病原性発現におけるシグナルペプチドペプチダーゼの役割, 岡本徹,相澤清香,杉山由加理,幸脇貴久,福原崇介,森石恆司,小池和彦,松浦善治, 2014/11
  • アポリポ蛋白質の両親媒性αヘリックスはHCVの感染性粒子産生に寄与する, 和田真実,福原崇介,中村昇太,小野慎子,山本聡美,塩川舞,岡本徹,小池和彦,松浦善治, 2014/11
  • C型肝炎ウイルスの感染におけるアポリポタンパク質受容体の役割, 山本聡美,福原崇介,小野慎子,和田真実,塩川舞,岡本徹,松浦善治, 2014/11
  • Amphipathic α-helices of Exchangeable Apolipoproteins Paticipate in the Particle Formation of Hepatitis C Virus, Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Satomi Yamamoto,Mai Shiokawa,Toru Okamoto,Kazuhiko Koike,Yoshiharu Matsuura, 2014/09
  • Characterization of HCV propagation in miR-122 knockout cells, Chikako Ono,Takasuke Fukuhara,Satomi Yamamoto,Masami Wada,Toru Okamoto,Daisuke Okuzaki,Yoshiharu Matsuura, 2014/09
  • Amphipathic α-helices of Exchangeable Apolipoproteins Paticipate in the Particle Formation of HCV, Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Satomi Yamamoto,Mai Shiokawa,Toru Okamoto,Kazuhiko Koike,Yoshiharu Matsuura, 2014/09
  • Processing of Core Protein by Signal Peptide Peptidase Participates in Propagation and Pathogenesis of Hepatitis C Virus, Toru Okamoto,Sayaka Aizawa,Takahisa Kouwaki,Tatsuya Suzuki,Francesc Puig-Basagoiti,Shinya Watanabe,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matsuura, 2014/09
  • Processing of Core Protein by Signal Peptide Peptidase Participates in Propagation and Pathogenesis of Hepatitis C Virus, Toru Okamoto,Sayaka Aizawa,Takahisa Kouwaki,Tatsuya Suzuki,Francesc Puig-Basagoiti,Shinya Watanabe,Takasuke Fukuhara,Kohji Moriishi,Kazuhiko Koike,Yoshiharu Matsuura, 2014/09
  • miR-122遺伝子欠損Huh7細胞株におけるC型肝炎ウイルス(HCV)の増殖, 福原 崇介,小野 慎子,塩川 舞,山本 聡美,和田 真実,奥崎 大介,岡本 徹,松浦 善治, 2014/08
  • Exchageable apolipoproteins participate in the particle formation of hepatitis C virus, Takasuke Fukuhara,Masami Wada,Shota Nakamura,Chikako Ono,Satomi Yamamoto,Mai Shiokawa,Toru Okamoto,Yoshiharu Matsuura, 2014/06
  • Characterization of HCV Propagation in miR-122 Knockout Cells, Chikako Ono,Takasuke Fukuhara,Mai Shiokawa,Satomi Yamamoto,Masami Wada,Toru Okamoto,Daisuke Okuzaki,Yoshiharu Matsuura, 2014/06
  • Further insights into the effects of pre-organizing the BimBH3 Helix, Toru Okamoto,David Segal,Kerry Zobel,Anna Fedorova,Hong Yang,Wayne J. Fairbrother,David C.S. Huang,Brian J. Smith,Kurt Deshayes,Peter E. Czabotar, ACS Chemical Biology, Vol. 9, No. 3, p. 838-839, 2014/02/18
  • Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells, Chikako Ono,Akinori Ninomiya,Satomi Yamamoto,Takayuki Abe,Xiauyu Wen,Takasuke Fukuhara,Miwa Sasai,Masahiro Yamamoto,Tatsuya Saitoh,Takashi Satoh,Taro Kawai,Ken J. Ishii,Shizuo Akira,Toru Okamoto,Yoshiharu Matsuura, Journal of Virology, Vol. 88, No. 4, p. 2157-2167, 2014/02
  • Hallmarks of hepatitis C virus in equine hepacivirus, Tomohisa Tanaka,Hirotake Kasai,Atsuya Yamashita,Kaori Okuyama-Dobashi,Jun Yasumoto,Shinya Maekawa,Nobuyuki Enomoto,Toru Okamoto,Yoshiharu Matsuura,Masami Morimatsu,Noboru Manabe,Kazuhiko Ochiai,Kazuto Yamashita,Kohji Moriishi, Journal of Virology, AMER SOC MICROBIOLOGY, Vol. 88, No. 22, p. 13352-13366, 2014
  • Novel permissive cell lines for complete propagation of hepatitis C virus, Mai Shiokawa,Takasuke Fukuhara,Chikako Ono,Satomi Yamamoto,Toru Okamoto,Noriyuki Watanabe,Takaji Wakita,Yoshiharu Matsuura, Journal of Virology, AMER SOC MICROBIOLOGY, Vol. 88, No. 10, p. 5578-5594, 2014
  • Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53, Gemma L. Kelly,Stephanie Grabow,Stefan P. Glaser,Leah Fitzsimmons,Brandon J. Aubrey,Toru Okamoto,Liz J. Valente,Mikara Robati,Lin Tai,W. Douglas Fairlie,Erinna F. Lee,Mikael S. Lindstrom,Klas G. Wiman,David C.S. Huang,Philippe Bouillet,Martin Rowe,Alan B. Rickinson,Marco J. Herold,Andreas Strasser, Genes and Development, COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, Vol. 28, No. 1, p. 58-70, 2014/01/01
  • Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis, Toru Okamoto,Leigh Coultas,Donald Metcalf,Mark F. Van Delft,Stefan P. Glaser,Megumi Takiguchi,Andreas Strasser,Philippe Bouillet,Jerry M. Adams,David C.S. Huang, Proceedings of the National Academy of Sciences of the United States of America, NATL ACAD SCIENCES, Vol. 111, No. 1, p. 261-266, 2014
  • HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia, Gabriela Brumatti,Marika Salmanidis,Chung H. Kok,Rebecca A. Bilardi,Jarrod J. Sandow,Natasha Silke,Kylie Mason,Jolanda Visser,Anissa M. Jabbour,Stefan P. Glaser,Toru Okamoto,Philippe Bouillet,Richard J. D'Andrea,Paul G. Ekert, Oncotarget, Impact Journals LLC, Vol. 4, No. 11, p. 1933-1947, 2013/11
  • Hoxb8 regulates expression of microRNAs to control cell death and differentiation, M. Salmanidis,G. Brumatti,N. Narayan,B. D. Green,J. A. Van Den Bergen,J. J. Sandow,A. G. Bert,N. Silke,R. Sladic,H. Puthalakath,L. Rohrbeck,T. Okamoto,P. Bouillet,M. J. Herold,G. J. Goodall,A. M. Jabbour,P. G. Ekert, Cell Death and Differentiation, Vol. 20, No. 10, p. 1370-1380, 2013/10
  • The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism, James M. Murphy,Peter E. Czabotar,Joanne M. Hildebrand,Isabelle S. Lucet,Jian Guo Zhang,Silvia Alvarez-Diaz,Rowena Lewis,Najoua Lalaoui,Donald Metcalf,Andrew I. Webb,Samuel N. Young,Leila N. Varghese,Gillian M. Tannahill,Esme C. Hatchell,Ian J. Majewski,Toru Okamoto,Renwick C.J. Dobson,Douglas J. Hilton,Jeffrey J. Babon,Nicos A. Nicola,Andreas Strasser,John Silke,Warren S. Alexander, Immunity, Vol. 39, No. 3, p. 443-453, 2013/09/19
  • Understanding the biological context of NS5A-host interactions in HCV infection: A network-based approach, Lokesh P. Tripathi,Hiroto Kambara,Yi An Chen,Yorihiro Nishimura,Kohji Moriishi,Toru Okamoto,Eiji Morita,Takayuki Abe,Yoshio Mori,Yoshiharu Matsuura,Kenji Mizuguchi, Journal of Proteome Research, Vol. 12, No. 6, p. 2537-2551, 2013/06/07
  • Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity, Toru Okamoto,Kerry Zobel,Anna Fedorova,Clifford Quan,Hong Yang,Wayne J. Fairbrother,David C.S. Huang,Brian J. Smith,Kurt Deshayes,Peter E. Czabotar, ACS Chemical Biology, Vol. 8, No. 2, p. 297-302, 2013/02/15
  • Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation, Hiroshi Katoh,Toru Okamoto,Takasuke Fukuhara,Hiroto Kambara,Eiji Morita,Yoshio Mori,Wataru Kamitani,Yoshiharu Matsuura, Journal of Virology, Vol. 87, No. 1, p. 489-502, 2013/01
  • Ifit1 inhibits japanese encephalitis virus replication through binding to 5= capped 2'-o unmethylated RNA, Taishi Kimura,Hiroshi Katoh,Hisako Kayama,Hiroyuki Saiga,Megumi Okuyama,Toru Okamoto,Eiji Umemoto,Yoshiharu Matsuur,Masahiro Yamamoto,Kiyoshi Takeda, Journal of Virology, Vol. 87, No. 18, p. 9997-10003, 2013
  • Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins, Toru Okamoto,Stephanie Campbell,Ninad Mehta,John Thibault,Peter M. Colman,Michele Barry,David C.S. Huang,Marc Kvansakul, Journal of Virology, Vol. 86, No. 21, p. 11501-11511, 2012/11
  • Bcl-2 family member Bcl-G is not a proapoptotic protein, M. Giam,T. Okamoto,J. D. Mintern,A. Strasser,P. Bouillet, Cell Death and Disease, Vol. 3, No. 10, 2012/10
  • A cluster of interferon-γ-inducible p65 gtpases plays a critical role in host defense against toxoplasma gondii, Masahiro Yamamoto,Megumi Okuyama,Ji Su Ma,Taishi Kimura,Naganori Kamiyama,Hiroyuki Saiga,Jun Ohshima,Miwa Sasai,Hisako Kayama,Toru Okamoto,David C.S. Huang,Dominique Soldati-Favre,Kyoji Horie,Junji Takeda,Kiyoshi Takeda, Immunity, Vol. 37, No. 2, p. 302-313, 2012/08/24
  • Arabidopsis β1,2-xylosyltransferase: Substrate specificity and participation in the plant-specific N-glycosylation pathway, Hiroyuki Kajiura,Toru Okamoto,Ryo Misaki,Yoshiharu Matsuura,Kazuhito Fujiyama, Journal of Bioscience and Bioengineering, SOC BIOSCIENCE BIOENGINEERING JAPAN, Vol. 113, No. 1, p. 48-54, 2012/01
  • ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18, Masahiro Yamamoto,Ji Su Ma,Christina Mueller,Naganori Kamiyama,Hiroyuki Saiga,Emi Kubo,Taishi Kimura,Toru Okamoto,Megumi Okuyama,Hisako Kayama,Kisaburo Nagamune,Seiji Takashima,Yoshiharu Matsuura,Dominique Soldati-Favre,Kiyoshi Takeda, Journal of Experimental Medicine, Vol. 208, No. 7, p. 1533-1546, 2011/07/04
  • Deerpox virus encodes an inhibitor of apoptosis that regulates bak and bax, Logan Banadyga,Sing Chi Lam,Toru Okamoto,Marc Kvansakul,David C. Huang,Michele Barry, Journal of Virology, Vol. 85, No. 5, p. 1922-1934, 2011/03
  • Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation, Kiyoko Okamoto,Yoshio Mori,Yasumasa Komoda,Toru Okamoto,Masayasu Okochi,Masatoshi Takeda,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura, Journal of Virology, Vol. 82, No. 17, p. 8349-8361, 2008/09
  • A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication, Toru Okamoto,Hiroko Omori,Yuuki Kaname,Takayuki Abe,Yorihiro Nishimura,Tetsuro Suzuki,Tatsuo Miyamura,Tamotsu Yoshimori,Kohji Moriishi,Yoshiharu Matsuura, Journal of Virology, Vol. 82, No. 7, p. 3480-3489, 2008/04
  • Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication, Shuhei Taguwa,Toru Okamoto,Takayuki Abe,Yoshio Mori,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura, Journal of Virology, Vol. 82, No. 6, p. 2631-2641, 2008/03
  • Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice, Takashi Kimura,Michio Imamura,Nobuhiko Hiraga,Tsuyoshi Hatakeyama,Daiki Miki,Chiemi Noguchi,Nami Mori,Masataka Tsuge,Shoichi Takahashi,Yoshifumi Fujimoto,Eiji Iwao,Hidenori Ochi,Hiromi Abe,Toshiro Maekawa,Keiko Arataki,Chise Tateno,Katsutoshi Yoshizato,Takaji Wakita,Toru Okamoto,Yoshiharu Matsuura,Kazuaki Chayama, Journal of General Virology, Vol. 89, No. 9, p. 2108-2113, 2008
  • Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency, Masahiro Yamamoto,Satoshi Uematsu,Toru Okamoto,Yoshiharu Matsuura,Shintaro Sato,Himanshu Kumar,Takashi Satoh,Tatsuya Saitoh,Kiyoshi Takeda,Ken J. Ishii,Osamu Takeuchi,Taro Kawai,Shizuo Akira, Journal of Experimental Medicine, Vol. 204, No. 9, p. 2233-2239, 2007/09/03
  • Oligomerization of hepatitis C virus core protein is crucial for interaction with the cytoplasmic domain of E1 envelope protein, Kousuke Nakai,Toru Okamoto,Tomomi Kimura-Someya,Koji Ishii,Chang Kweng Lim,Hideki Tani,Eiko Matsuo,Takayuki Abe,Yoshio Mori,Tetsuro Suzuki,Tatsuo Miyamura,Jack H. Nunberg,Kohji Moriishi,Yoshiharu Matsuura, Journal of Virology, Vol. 80, No. 22, p. 11265-11273, 2006/11
  • Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90, Toru Okamoto,Yorihiro Nishimura,Tohru Ichimura,Kensuke Suzuki,Tatsuo Miyamura,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura, EMBO Journal, Vol. 25, No. 20, p. 5015-5025, 2006/10/18
  • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Masahiro Yamamoto,Toru Okamoto,Kiyoshi Takeda,Shintaro Sato,Hideki Sanjo,Satoshi Uematsu,Tatsuya Saitoh,Naoki Yamamoto,Hiroaki Sakurai,Ken J. Ishii,Shoji Yamaoka,Taro Kawai,Yoshiharu Matsuura,Osamu Takeuchi,Shizuo Akira, Nature Immunology, Vol. 7, No. 9, p. 962-970, 2006/09
  • Characterization of HCV-like particles produced in a human hepatoma cell line by a recombinant baculovirus, Eiko Matsuo,Hideki Tani,Chang Kweng Lim,Yasumasa Komoda,Toru Okamoto,Hironobu Miyamoto,Kohji Moriishi,Shintaro Yagi,Arvind H. Patel,Tatsuo Miyamura,Yoshiharu Matsuura, Biochemical and Biophysical Research Communications, Vol. 340, No. 1, p. 200-208, 2006/02/03
  • Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication, Yoshimi Tsuda,Yoshio Mori,Takayuki Abe,Tetsuo Yamashita,Toru Okamoto,Tohru Ichimura,Kohji Moriishi,Yoshiharu Matsuura, Microbiology and Immunology, Center for Academic Publications Japan, Vol. 50, No. 3, p. 225-234, 2006
  • Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B, Itsuki Hamamoto,Yorihiro Nishimura,Toru Okamoto,Hideki Aizaki,Minyi Liu,Yoshio Mori,Takayuki Abe,Tetsuro Suzuki,Michael M.C. Lai,Tatsuo Miyamura,Kohji Moriishi,Yoshiharu Matsuura, Journal of Virology, Vol. 79, No. 21, p. 13473-13482, 2005/11
  • Effect of heparin addition on expansion of cord blood hematopoietic progenitor cells in three-dimensional coculture with stromal cells in nonwoven fabrics, Toru Okamoto,Mutsumi Takagi,Toshihiro Soma,Hiroyasu Ogawa,Manabu Kawakami,Masaaki Mukubo,Kazusuke Kubo,Reiko Sato,Kazunori Toma,Toshiomi Yoshida, Journal of Artificial Organs, Vol. 7, No. 4, p. 194-202, 2004/12

Misc.

  • Indoleamine-2, 3-dioxygenase as the intrinsic anti-HBV effector that leads to durable immune responses in patients with acute hepatitis B: A comparative analysis with the sequence in hepatic flare, Sachiyo Yoshio,Masaya Sugiyama,Hirotaka Shoji,Yohei Mano,Yoshihiko Aoki,Toru Okamoto,Yoshiharu Matsuura,Masashi Mizokami,Tatsuya Kanto, HEPATOLOGY, WILEY-BLACKWELL, Vol. 62, p. 1010A-1010A, 2015/10
  • CRISPR/CAS9法によるPresenilin1/Presenilin2ダブルノックアウト細胞の作製, 柳田 寛太,田上 真次,児玉 高志,岡本 徹,松浦 善治,武田 雅俊,大河内 正康, Dementia Japan, (一社)日本認知症学会, Vol. 29, No. 3, p. 421-421, 2015/09
  • Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90 (vol 25, pg 5015, 2006), Toru Okamoto,Yorihiro Nishimura,Tohru Ichimura,Kensuke Suzuki,Tatsuo Miyamura,Tetsuro Suzuki,Kohji Moriishi,Yoshiharu Matsuura, EMBO JOURNAL, NATURE PUBLISHING GROUP, Vol. 25, No. 23, p. 5634-5634, 2006/11

Presentations

  • ウイルスによる宿主への感染戦略, 岡本徹, 宮崎大学医学獣医学総合研究科 大学院特別セミナー, 2021/01
  • ウイルス感染における細胞死の制御, 岡本徹、鈴木達也、伊東祐美、平野順紀, 第 93 回日本生化学会大会, 2020/09
  • ウイルスによる宿主への感染戦略, 岡本徹, 公益財団法人 川崎市産業振興財団 第28回 Tonomachi cafe, 2020/08