Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

Ryoji Kawakami, Yohko Kitagawa, Kelvin Y. Chen, Masaya Arai, Daiya Ohara, Yamami Nakamura, Keiko Yasuda, Motonao Osaki, Norihisa Mikami, Caleb A. Lareau, Hitomi Watanabe, Gen Kondoh, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi

Immunity　Vol. 54　No. 5　p. 947-961.e8　2021/05　Research paper (scientific journal)

Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander

Masaki Inoue, Kanako Yamashita, Yuta Tsuji, Midori Miki, Shota Amano, Taichi Okumura, Koki Kuge, Takao Tone, Shota Enomoto, Chinatsu Yoshimine, Yuki Morita, Daisuke Ando, Haruhiko Kamada, Norihisa Mikami, Yasuo Tsutsumi, Shin-ichi Tsunoda

The Journal of Immunology　Vol. 206　No. 8　p. 1740-1751　2021/04/15　Research paper (scientific journal)

Characterization of an Expanded IL-10-Producing-Suppressive T Cell Population Associated with Immune Tolerance.

Yuya Yoshida, Norihisa Mikami, Yusuke Nakanishi, Maya Saimoto, Arata Nagaike, Haruka Shimono, Shohei Nakano, Takumi Tsuji, Takeyuki Kohno

Biological & pharmaceutical bulletin　Vol. 44　No. 4　p. 585-589　2021/04/01　Research paper (scientific journal)

New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression

Norihisa Mikami, Ryoji Kawakami, Shimon Sakaguchi

Current Opinion in Immunology　Vol. 67　p. 36-41　2020/12　Research paper (scientific journal)

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Norihisa Mikami, Ryoji Kawakami, Kelvin Y. Chen, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi

Proceedings of the National Academy of Sciences　Vol. 117　No. 22　p. 12258-12268　2020/06/02　Research paper (scientific journal)

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19.

Masahiko Akamatsu, Norihisa Mikami, Naganari Ohkura, Ryoji Kawakami, Yohko Kitagawa, Atsushi Sugimoto, Keiji Hirota, Naoto Nakamura, Satoru Ujihara, Toshio Kurosaki, Hisao Hamaguchi, Hironori Harada, Guliang Xia, Yoshiaki Morita, Ichiro Aramori, Shuh Narumiya, Shimon Sakaguchi

Science immunology　Vol. 4　No. 40　2019/10/25　Research paper (scientific journal)

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda

CELL REPORTS　Vol. 21　No. 7　p. 1824-1838　2017/11　Research paper (scientific journal)

Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function

Takashi Hosokawa, Tetsuya Kimura, Shigeyuki Nada, Tatsusada Okuno, Daisuke Ito, Sujin Kang, Satoshi Nojima, Kazuya Yamashita, Takeshi Nakatani, Yoshitomo Hayama, Yasuhiro Kato, Yuhei Kinehara, Masayuki Nishide, Norihisa Mikami, Syohei Koyama, Hyota Takamatsu, Daisuke Okuzaki, Naganari Ohkura, Shimon Sakaguchi, Masato Okada, Atsushi Kumanogoh

JOURNAL OF IMMUNOLOGY　Vol. 199　No. 6　p. 2008-2019　2017/09　Research paper (scientific journal)

Transcription factors downstream of IL-4 and TGF-β signals: Analysis by quantitative PCR, Western blot, and flow cytometry

Atsushi Sugimoto, Ryoji Kawakami, Norihisa Mikami

Methods in Molecular Biology　Vol. 1585　p. 141-153　2017　Part of collection (book)

Combination treatment with fingolimod and a pathogenic antigen prevents relapse of glucose-6-phosphate isomerase peptide-induced arthritis.

Yoshida Y, Mikami N, Matsushima Y, Miyawaki M, Endo H, Banno R, Tsuji T, Fujita T, Kohno T

Immunity, inflammation and disease　Vol. 4　No. 3　p. 263-273　2016/09　Research paper (scientific journal)

Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system

Alexis Vandenbon, Viet H. Dinh, Norihisa Mikami, Yohko Kitagawa, Shunsuke Teraguchi, Naganari Ohkura, Shimon Sakaguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　Vol. 113　No. 17　p. E2393-E2402　2016/04　Research paper (scientific journal)

Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche

Masahiko Yamaguchi, Yoko Watanabe, Takuji Ohtani, Akiyoshi Uezumi, Norihisa Mikami, Miki Nakamura, Takahiko Sato, Masahito Ikawa, Mikio Hoshino, Kunihiro Tsuchida, Yuko Miyagoe-Suzuki, Kazutake Tsujikawa, Shin'ichi Takeda, Hiroshi Yamamoto, So-ichiro Fukada

CELL REPORTS　Vol. 13　No. 2　p. 302-314　2015/10　Research paper (scientific journal)

Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod Plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Modelle

Yuya Yoshida, Norihisa Mikami, Yuki Matsushima, Fumiya Otani, Mai Miyawaki, Miku Takatsuji, Rie Banno, Takumi Tsuji, Tetsuro Fujita, Kazutake Tsujikawa, Takeyuki Kohno

BIOLOGICAL & PHARMACEUTICAL BULLETIN　Vol. 38　No. 8　p. 1120-1125　2015/08　Research paper (scientific journal)

Mechanism of induction of immune tolerance in experimental autoimmune encephalomyelitis by combination treatment with fingolimod plus pathogenic autoantigen

Yuya Yoshida, Norihisa Mikami, Takumi Tsuji, Yuki Takada, Yuka Nakazawa, Rie Dan, Miku Takatsuji, Tetsuro Fujita, Kazutake Tsujikawa, Takeyuki Kohno

Clinical and Experimental Neuroimmunology　Vol. 6　No. 1　p. 49-56　2015/02/01　Research paper (scientific journal)

CD28 signals the differential control of regulatory T cells and effector T cells

Norihisa Mikami, Shimon Sakaguchi

EUROPEAN JOURNAL OF IMMUNOLOGY　Vol. 44　No. 4　p. 955-957　2014/04

Calcitonin Gene-Related Peptide Regulates Type IV Hypersensitivity through Dendritic Cell Functions

Norihisa Mikami, Kaori Sueda, Yusuke Ogitani, Ippei Otani, Miku Takatsuji, Yasuko Wada, Keiko Watanabe, Rintaro Yoshikawa, Satoshi Nishioka, Nagisa Hashimoto, Yayoi Miyagi, Soichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

PLOS ONE　Vol. 9　No. 1　2014/01　Research paper (scientific journal)

Calcitonin Gene-Related Peptide and Cyclic Adenosine 5 '-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 Differentiation Process

Norihisa Mikami, Yayoi Miyagi, Kaori Sueda, Miku Takatsuji, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

JOURNAL OF IMMUNOLOGY　Vol. 190　No. 8　p. 4046-4055　2013/04　Research paper (scientific journal)

Calcitonin gene-related peptide enhances experimental autoimmune encephalomyelitis by promoting T(h)17-cell functions

Norihisa Mikami, Keiko Watanabe, Nagisa Hashimoto, Yayoi Miyagi, Kaori Sueda, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

INTERNATIONAL IMMUNOLOGY　Vol. 24　No. 11　p. 681-691　2012/11　Research paper (scientific journal)

The Regulatory Mechanisms of Calcitonin Gene-related Peptide (CGRP) in Skin Inflammation

Norihisa Mikami, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　Vol. 132　No. 11　p. 1211-1215　2012/11

Calcitonin gene-related peptide is an important regulator of cutaneous immunity

MIKAMI Norihisa, FUKADA So-ichiro, YAMAMOTO Hiroshi, TSUJIKAWA Kazutake

Annual Meeting of the Japanese Society of Toxicology　Vol. 39　p. MS2-3　2012

Neuronal Derivative Mediators That Regulate Cutaneous Inflammations

Norihisa Mikami, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

CRITICAL REVIEWS IN IMMUNOLOGY　Vol. 32　No. 4　p. 307-320　2012　Research paper (scientific journal)

Suppression of ovalbumin-induced allergic diarrhea by diminished intestinal peristalsis in RAMP1-deficient mice

Rintaro Yoshikawa, Norihisa Mikami, Ippei Otani, Taeko Kishimoto, Satoshi Nishioka, Nagisa Hashimoto, Yayoi Miyagi, Yutaro Takuma, Kaori Sueda, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　Vol. 410　No. 3　p. 389-393　2011/07　Research paper (scientific journal)

Calcitonin Gene-Related Peptide Is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions

Norihisa Mikami, Hiroaki Matsushita, Tetsuya Kato, Rumi Kawasaki, Taichi Sawazaki, Taeko Kishimoto, Yusuke Ogitani, Keiko Watanabe, Yayoi Miyagi, Kaori Sueda, So-ichiro Fukada, Hiroshi Yamamoto, Kazutake Tsujikawa

JOURNAL OF IMMUNOLOGY　Vol. 186　No. 12　p. 6886-6893　2011/06　Research paper (scientific journal)