Asakawa Haruhiko

淺川 東彦

Graduate School of Frontier Biosciences Department of Frontier Biosciences, Associate Professor

Research Areas

  • Life sciences, Genetics
  • Life sciences, Cell biology
  • Life sciences, Molecular biology

Professional Memberships



  • Transient Breakage of the Nucleocytoplasmic Barrier Controls Spore Maturation via Mobilizing the Proteasome Subunit Rpn11 in the Fission Yeast Schizosaccharomyces pombe., Hui-Ju Yang,Haruhiko Asakawa,Chizuru Ohtsuki,Tokuko Haraguchi,Yasushi Hiraoka, Journal of fungi (Basel, Switzerland), Vol. 6, No. 4, 2020/10/23
  • Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast., Yasuhiro Hirano,Haruhiko Asakawa,Takeshi Sakuno,Tokuko Haraguchi,Yasushi Hiraoka, Cells, {MDPI} {AG}, Vol. 9, No. 8, p. 1908-1908, 2020/08/16
  • Human Ebp1 rescues the synthetic lethal growth of fission yeast cells lacking Cdb4 and Nup184, Osaretin P. Osemwenkhae,Takeshi Sakuno,Yasuhiro Hirano,Haruhiko Asakawa,Yoko Hayashi‐Takanaka,Tokuko Haraguchi,Yasushi Hiraoka, Genes to Cells, Wiley, 2020/04
  • Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast, Haruhiko Asakawa,Tomoko Kojidani,Hui-Ju Yang,Chizuru Ohtsuki,Hiroko Osakada,Atsushi Matsuda,Masaaki Iwamoto,Yuji Chikashige,Koji Nagao,Chikashi Obuse,Yasushi Hiraoka,Tokuko Haraguchi, PLOS Genetics, 2019/06/06
  • The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells, Yasuha Kinugasa,Yasuhiro Hirano,Megumi Sawai,Yusuke Ohno,Tomoko Shindo,Haruhiko Asakawa,Yuji Chikashige,Shinsuke Shibata,Akio Kihara,Tokuko Haraguchi,Yasushi Hiraoka, Journal of Cell Science, The Company of Biologists, 2019/05/15
  • Visualization of secretory cargo transport within the Golgi apparatus, Kazuo Kurokawa,Hiroko Osakada,Tomoko Kojidani,Miho Waga,Yasuyuki Suda,Haruhiko Asakawa,Tokuko Haraguchi,Akihiko Nakano, The Journal of Cell Biology, Rockefeller University Press, Vol. 218, No. 5, p. 1602-1618, 2019/05/06
  • Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast, Yasuhiro Hirano,Yasuha Kinugasa,Haruhiko Asakawa,Yuji Chikashige,Chikashi Obuse,Tokuko Haraguchi,Yasushi Hiraoka, Genes to Cells, Wiley-Blackwell, Vol. 23, No. 3, p. 122-135, 2018/03/02
  • Estimation of GFP-nucleoporin amount based on fluorescence microscopy, Asakawa, H.,Hiraoka, Y.,Haraguchi, T., Methods in Molecular Biology, Methods in Molecular Biology, Vol. 1721, p. 105-115, 2018
  • Shelterin promotes tethering of late replication origins to telomeres for replication-timing control, Ogawa, S.,Kido, S.,Handa, T.,Ogawa, H.,Asakawa, H.,Takahashi, T.S.,Nakagawa, T.,Hiraoka, Y.,Masukata, H., EMBO Journal, Vol. 37, No. 15, 2018
  • Telomere-binding proteins and sheltering components regulate spatiotemporal chromosomal DNA replication programs in fission yeast, Shiho Ogawa,Tetsuya Handa,Sayuri Kido,Yuta Nakamura,Hidesato Ogawa,Haruhiko Asakawa,Tatsuro Takahashi,Takuro Nakagawa,Yasushi Hiraoka,Hisao Masukata, 2017/12
  • Microscopic Observation of Living Cells Stained with Fluorescent Probes., Asakawa H,Ding DQ,Haraguchi T,Hiraoka Y, Cold Spring Harbor protocols, Vol. 2017, No. 10, 2017/10
  • Spatial organization of the Schizosaccharomyces pombe genome within the nucleus., Matsuda A,Asakawa H,Haraguchi T,Hiraoka Y, Yeast (Chichester, England), Vol. 34, No. 2, p. 55-66, 2017/02
  • Temporal and spatial regulation of replication by telomere binding proteins in fission yeast, Shiho Ogawa,Tetsuya Handa,Yuta Nakamura,Tatsuro Takahashi,Takuro Nakagawa,Hidesato Ogawa,Haruhiko Asakawa,Yasushi Hiraoka,Hisao Masukata, 2016/11
  • A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation., Sato Y,Kujirai T,Arai R,Asakawa H,Ohtsuki C,Horikoshi N,Yamagata K,Ueda J,Nagase T,Haraguchi T,Hiraoka Y,Kimura A,Kurumizaka H,Kimura H, Journal of molecular biology, Vol. 428, No. 20, p. 3885-3902, 2016/10
  • A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation, Sato, Yuko,Kujirai, Tomoya,Arai, Ritsuko,Asakawa, Haruhiko,Ohtsuki, Chizuru,Horikoshi, Naoki,Yamagata, Kazuo,Ueda, Jun,Nagase, Takahiro,Haraguchi, Tokuko,Hiraoka, Yasushi,Kimura, Akatsuki,Kurumizaka, Hitoshi,Kimura, Hiroshi, Journal of molecular biology, Vol. 428, No. 20, p. 3885-3902, 2016/04
  • Virtual Nuclear Envelope Breakdown and Its Regulators in Fission Yeast Meiosis., Asakawa H,Yang HJ,Hiraoka Y,Haraguchi T, Frontiers in cell and developmental biology, Vol. 4, 2016
  • Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions, Tange, Y.,Chikashige, Y.,Takahata, S.,Kawakami, K.,Higashi, M.,Mori, C.,Kojidani, T.,Hirano, Y.,Asakawa, H.,Murakami, Y.,Haraguchi, T.,Hiraoka, Y., Genes to Cells, Vol. 21, No. 8, p. 812-832, 2016
  • Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly., Yang HJ,Asakawa H,Haraguchi T,Hiraoka Y, The Journal of cell biology, Vol. 211, No. 2, p. 295-308, 2015/10
  • Biased assembly of the nuclear pore complex is required for somatic and germline nuclear differentiation in Tetrahymena., Iwamoto M,Koujin T,Osakada H,Mori C,Kojidani T,Matsuda A,Asakawa H,Hiraoka Y,Haraguchi T, Journal of cell science, Vol. 128, No. 9, p. 1812-1823, 2015/05
  • Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway., Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Masukata H,Haraguchi T,Hiraoka Y, Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, No. 3, p. 160-172, 2015/03
  • Uncleavable Nup98-Nup96 is functional in the fission yeast Schizosaccharomyces pombe., Asakawa H,Mori C,Ohtsuki C,Iwamoto M,Hiraoka Y,Haraguchi T, FEBS open bio, Vol. 5, p. 508-514, 2015
  • Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast., Matsuda A,Chikashige Y,Ding DQ,Ohtsuki C,Mori C,Asakawa H,Kimura H,Haraguchi T,Hiraoka Y, Nature communications, Vol. 6, 2015
  • Histone H4 acetylation required for chromatin decompaction during DNA replication., Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y, Scientific Reports, Vol. 5, 2015
  • A method of correlative light and electron microscopy for yeast cells, Haruhiko Asakawa,Yasushi Hiraoka,Tokuko Haraguchi, Micron, Vol. 61, p. 53-61, 2014/06
  • Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe, Haruhiko Asakawa,Hui-Ju Yang,Takaharu G. Yamamoto,Chizuru Ohtsuki,Yyuji Chikashige,Kumiko Sakata-Sogawa,Makio Tokunaga,Masaaki Iwamoto,Yyasushi Hiraoka,Tokuko Haraguchi, Nucleus (United States), Landes Bioscience, Vol. 5, No. 2, p. 149-162, 2014/03/12
  • Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe., Asakawa H,Yang HJ,Yamamoto TG,Ohtsuki C,Chikashige Y,Sakata-Sogawa K,Tokunaga M,Iwamoto M,Hiraoka Y,Haraguchi T, Nucleus (Austin, Tex.), Vol. 5, No. 2, p. 149-162, 2014
  • Meiotic nuclear movement in fission yeast is prolonged by stalled DNA replication through a Cds1-dependent checkpoint pathway, Kun Ruan,Takaharu G Yamamoto,Haruhiko Asakawa,Yuji Chikashige,Tokuko Haraguchi,Hisao Masukata,Yasushi Hiraoka, 2013/06
  • Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans., Iwamoto M,Asakawa H,Ohtsuki C,Osakada H,Koujin T,Hiraoka Y,Haraguchi T, Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, No. 2, p. 81-90, 2013/04
  • Live CLEM imaging: an application for yeast cells., Asakawa H,Hiraoka Y,Haraguchi T, Current microscopy contributions to advances in science and technology, Vol. 1, p. 478-485, 2012/12
  • Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres., Hiraoka Y,Maekawa H,Asakawa H,Chikashige Y,Kojidani T,Osakada H,Matsuda A,Haraguchi T, Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, No. 10, p. 1000-1011, 2011/10
  • Nuclear translocation of RanGAP1 coincides with virtual nuclear envelope breakdown in fission yeast meiosis., Asakawa H,Hiraoka Y,Haraguchi T, Communicative & integrative biology, Vol. 4, No. 3, p. 312-314, 2011/05
  • Physical breakdown of the nuclear envelope is not necessary for breaking its barrier function., Asakawa H,Hiraoka Y,Haraguchi T, Nucleus (Austin, Tex.), Vol. 2, No. 6, p. 523-526, 2011
  • Virtual breakdown of the nuclear envelope in fission yeast meiosis., Asakawa H,Kojidani T,Mori C,Osakada H,Sato M,Ding DQ,Hiraoka Y,Haraguchi T, Current biology : CB, Vol. 20, No. 21, p. 1919-1925, 2010/11
  • Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms., Iwamoto M,Asakawa H,Hiraoka Y,Haraguchi T, Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, No. 7, p. 661-669, 2010/06
  • Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast, Onishi, M.,Koga, T.,Hirata, A.,Nakamura, T.,Asakawa, H.,Shimoda, C.,Bähler, J.,Wu, J.-Q.,Takegawa, K.,Tachikawa, H.,Pringle, J.R.,Fukui, Y., Molecular and Cellular Biology, Vol. 30, No. 8, p. 2057-2074, 2010
  • In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells, Kawai-Noma, S.,Pack, C.-G.,Kojidani, T.,Asakawa, H.,Hiraoka, Y.,Kinjo, M.,Haraguchi, T.,Taguchi, H.,Hirata, A., Journal of Cell Biology, Vol. 190, No. 2, p. 223-231, 2010
  • Live-cell fluorescence imaging of meiotic chromosome dynamics in Schizosaccharomyces pombe., Asakawa H,Hiraoka Y, Methods in molecular biology (Clifton, N.J.), Vol. 558, p. 53-64, 2009
  • Live observation of forespore membrane formation in fission yeast, Nakamura, T.,Asakawa, H.,Nakase, Y.,Kashiwazaki, J.,Hiraoka, Y.,Shimoda, C., Molecular Biology of the Cell, Vol. 19, No. 8, p. 3544-3553, 2008
  • Reconstruction of the kinetochore: a prelude to meiosis., Asakawa H,Haraguchi T,Hiraoka Y, Cell division, Vol. 2, 2007
  • 減数分裂と染色体動態, 淺川 東彦,平岡 泰, 蛋白質・核酸・酵素, Vol. 51, No. 14, p. 2159-2164, 2006/04
  • Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe, Hayashi, A.,Asakawa, H.,Haraguchi, T.,Hiraoka, Y., Molecular Biology of the Cell, Vol. 17, No. 12, p. 5173-5184, 2006
  • Dissociation of the Nuf2-Ndc80 complex releases centromeres from the spindle-pole body during meiotic prophase in fission yeast, Asakawa, H.,Hayashi, A.,Haraguchi, T.,Hiraoka, Y., Molecular Biology of the Cell, Vol. 16, No. 5, p. 2325-2338, 2005
  • セントロメアとテロメアの分子イメージング, 平岡 泰,淺川 東彦,近重 裕次, 細胞核のダイナミクス, シュプリンガー・フェアラーク東京, 2004/04
  • A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe., Molecular genetics and genomics : MGG, 2001/05


  • Fission yeast meets a legend in Kobe: report of the Eighth International Fission Yeast Meeting., Asakawa H,Yamamoto TG,Hiraoka Y, Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, No. 12, p. 967-971, 2015/12
  • 蛍光・電子顕微鏡両用プローブを用いた分子特異的ナノイメージング法の開発, 原口徳子,原口徳子,糀谷知子,淺川東彦,森知栄,小坂田裕子,小林昇平,平岡泰,平岡泰, 医学生物学電子顕微鏡技術学会誌, Vol. 25, No. 2, 2011/09
  • 酵母細胞内でSup35プリオンタンパク質が線維状構造を形成している証拠, 河合(野間)繁子,PACK Changi,平田愛子,糀谷知子,淺川東彦,平岡泰,平岡泰,金城政孝,原口徳子,原口徳子,田口英樹, 日本蛋白質科学会年会プログラム・要旨集, Vol. 11th, 2011/05/27
  • Expression mechanism of a nucleoporin gene encoding Nup98-Nup96 homologue in fission yeast., ASAKAWA HARUHIKO,MORI CHIE,HIRAOKA YASUSHI,HIRAOKA YASUSHI,HARAGUCHI TOKUKO,HARAGUCHI TOKUKO, 生化学, 2010
  • 酵母細胞内でSup35プリオンタンパク質が線維状構造を形成している証拠, 田口英樹,河合(野間)繁子,PACK C‐G,糀谷知子,淺川東彦,平岡泰,金城政孝,原口徳子,平田愛子, 日本生体エネルギー研究会討論会講演要旨集, Vol. 36th, 2010
  • 核膜孔蛋白質Nup98は核移行のバリアとして働く, 原口徳子,岩本政明,森千栄,小坂田裕子,荒神尚子,武内史英,小林昇平,淺川東彦,淺川東彦,平岡泰,平岡泰,平岡泰, 生化学, 2009/09/25
  • 分裂酵母における核膜孔複合体蛋白質の生細胞観察, 淺川東彦,淺川東彦,林亜紀,平岡泰,平岡泰,原口徳子,原口徳子, 生化学, 2008
  • 増殖分裂と生殖分裂における核膜と核膜孔複合体ダイナミクス, 原口徳子,淺川東彦,近重裕次,岩本政明,武内史英,糀谷知子,小坂田裕子,荒神尚子,山本章嗣,平岡泰,平岡泰, 生化学, 2007
  • Chromosome dynamics during meiosis, Asakawa, H.,Hiraoka, Y., Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 51, No. 14 Suppl, p. 2159-2164, 2006
  • 減数分裂前期でセントロメア局在減少を示す分裂酵母キネトコア蛋白質群の解析, 林亜紀,林亜紀,浅川東彦,浅川東彦,原口徳子,原口徳子,平岡泰,平岡泰, 日本分子生物学会年会講演要旨集, Vol. 28th, 2005/11/25
  • Biotechnology and Neurotechnology-Biological and Neurological Information in Telecommunications Technology-Genome-wide Analysis of Gene Functions, CHIKASHIGE YUJI,DING D-Q,YAMAMOTO AYUMU,HAYASHI AKI,ASAKAWA HARUHIKO,MASUDA HIROHISA,HARAGUCHI TOKUKO,HIRAOKA YASUSHI, 情報通信研究機構季報, Vol. 50, No. 3/4, 2005/03/14
  • Nuf2セントロメアタンパク質の消失は減数分裂前期におけるセントロメアの核内配置変化に関与する, 浅川東彦,平岡泰, 日本分子生物学会年会プログラム・講演要旨集, Vol. 27th, 2004/11/25
  • Genome-wide analysis of gene function, Yuji Chikashige,Da Qiao Ding,Ayumu Yamamoto,Aki Hayashi,Haruhiko Asakawa,Hirohisa Masuda,Tokuko Haraguchi,Yasushi Hiraoka, Journal of the National Institute of Information and Communications Technology, Vol. 51, No. 3-4, p. 35-38, 2004/09
  • 減数分裂前期にセントロメア‐SPBの解離に伴って消失する分裂酵母セントロメアタンパク質群, 浅川東彦,平岡泰, 日本分子生物学会年会プログラム・講演要旨集, Vol. 26th, 2003/11/25
  • 分裂酵母セントロメアタンパク質による減数分裂の制御, 淺川東彦,平岡泰, 日本細胞生物学会大会講演要旨集, Vol. 56th, 2003
  • 分裂酵母のセントロメアタンパク質Nuf2,Ndc80,Spc24の減数分裂時の挙動, 淺川東彦,鍋谷彰,平岡泰, 日本細胞生物学会大会講演要旨集, Vol. 55th, 2002

Media Coverage

  • 真核生物の解明につながる発見 分裂酵母が核膜孔複合体アウターリング構造を保持, 2019/06/14
  • Nuclear pore complex outer rings: No longer 'one size fits all', 2019/06/07
  • Nuclear pore complex outer rings: No longer 'one size fits all', 2019/06/07
  • Nuclear pore complex outer rings: No longer 'one size fits all, 2019/06/07
  • 分裂酵母が独特の核膜孔複合体アウターリング構造をもつことを解明, 2019/06/07
  • Nuclear pore complex outer rings: No longer 'one size fits all', 2019/06/07
  • 単細胞生物にサバイバルの知恵 栄養不足なら省エネ分裂, 2010/12/27
  • 酵母菌の細胞核分裂 新プロセス発見 「分子通信」実現へ, 2010/10/22
  • 酵母、核膜破れず 生物進化過程解明へ, 2010/10/22