Shiraishi Miyako

白石 都

Graduate School of Engineering Science Department of Materials Engineering Science, Assistant Professor

keyword DNA replication,thermophiles,Archaea,DNA repair


  • 2014/04 - 2017/03, Kyushu University, Ph.D. in Agricultural Science, Graduate School of Bioresource and Bioenvironmental Science
  • 2012/04 - 2014/03, Kyushu University, M.A. of Agricultural Science, Graduate School of Bioresource and Bioenvironmental Science
  • 2008/04 - 2012/03, Kyushu University, B.A. of Agricultural Science, School of Agriculture and Bioenvironmental Science

Research History

  • 2018/09 - Present, Osaka University, 大学院 基礎工学研究科, Assistant Professor
  • 2017/04 - 2017/08, 九州大学大学院, 農学研究院, 学術特定研究者
  • 2014/04 - 2017/03, 日本学術振興会 特別研究員 DC1
  • 2014/05 - 2016/12, University of Illinois at Urbana-Champaign, Visiting Scholar

Research Areas

  • Life sciences, Applied biochemistry, アーキア(古細菌)
  • Life sciences, Applied microbiology


  • Mutational analysis of Thermococcus kodakarensis endonuclease III reveals the roles of evolutionarily conserved residues, Miyako Shiraishi,Kento Mizutani,Junpei Yamamoto,Shigenori Iwai, DNA Repair, Vol. 90, 2020/06
  • Molecular Basis of Substrate Recognition of Endonuclease Q from the Euryarchaeon Pyrococcus furiosus., Shiraishi M,Iwai S, Journal of bacteriology, Vol. 202, No. 2, 2020/01
  • The mesophilic archaeon Methanosarcina acetivorans counteracts uracil in DNA with multiple enzymes: EndoQ, ExoIII, and UDG., Shiraishi M,Ishino S,Heffernan M,Cann I,Ishino Y, Scientific reports, Vol. 8, No. 1, 2018/10
  • Fluorescence detection of DNA mismatch repair in human cells., Ito S,Shiraishi M,Tsuchihashi K,Takatsuka R,Yamamoto J,Kuraoka I,Iwai S, Scientific reports, Vol. 8, No. 1, 2018/08
  • A functional endonuclease Q exists in the bacterial domain: identification and characterization of endonuclease Q from Bacillus pumilus, Miyako Shiraishi,Sonoko Ishino,Isaac Cann,Yoshizumi Ishino, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, TAYLOR & FRANCIS LTD, Vol. 81, No. 5, p. 931-937, 2017/05
  • PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales, Miyako Shiraishi,Sonoko Ishino,Kotaro Yoshida,Takeshi Yamagami,Isaac Cann,Yoshizumi Ishino, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 6, 2016/05
  • EndoQ and EndoV work individually for damaged DNA base repair in Pyrococcus furiosus, Sonoko Ishino,Naruto Makita,Miyako Shiraishi,Takeshi Yamagami,Yoshizumi Ishino, BIOCHIMIE, ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, Vol. 118, p. 264-269, 2015/11
  • A novel endonuclease that may be responsible for damaged DNA base repair in Pyrococcus furiosus, Miyako Shiraishi,Sonoko Ishino,Takeshi Yamagami,Yuriko Egashira,Shinichi Kiyonari,Yoshizumi Ishino, NUCLEIC ACIDS RESEARCH, OXFORD UNIV PRESS, Vol. 43, No. 5, p. 2853-2863, 2015/03

Industrial Property Rights

  • Novel DNA cleavage enzyme, Ishino, Y,Ishino, S,Shiraishi, M, 特願14/890,009


  • 平成28年度生物資源環境科学府賞, 白石 都, 2017/03
  • 九州大学学生表彰受賞, 白石 都, 2017/03
  • 平成28年度日本農芸化学会西日本支部奨励賞(学生), 白石 都, 2017/01
  • The International Society for Extremophiles Poster Award, Miyako Shiraishi, The International Society for Extremophiles, 2016/09
  • Poster Awards for Young Scientists, Miyako Shiraishi, Protein Science Society of Japan, 2013/06


  • Thermococcus kodakarensis由来エンドヌクレアーゼIIIとその変異体を用いた機能解析, 水谷謙斗,山元淳平,岩井成憲,白石都, 第42回日本分子生物学会年会, 2019/12
  • Substrate recognition mechanisms of Endonuclease Q from the euryarchaeon Pyrococcus furiosus, Miyako Shiraishi,Shigenori Iwai, The 42nd Annual Meeting of the Molecular Biology Society of Japan, 2019/12
  • Endonuclease Q Acts on Various Mutagenic Bases in Hyperthermophilic Archaea, Shiraishi, M,Ishino,S. Yamagami, T,Egashira, Y,Kiyonari, S,Iwai, S,Ishino, Y, Thermophiles2019 (15th International Congress), 2019/09
  • A Novel DNA Repair Pathway for Damaged Bases in Thermococcales, Shiraishi, M,Ishono, S,Egashira, Y,Kiyonari, S,Yamagami, T,Cann, I,Ishino, Y, Extremophiles2016 (11th International Congress), 2016/09
  • A novel DNA repair pathway found in achaeal order Thermococcales, Shiraishi, M,Ishono, S,Egashira, Y,Kiyonari, S,Yamagami, T,Cann, I,Ishino, Y, Molecular Biology of Archaea 5, 2016/08
  • A novel endonuclease responsible for damaged DNA repair in archaeal order Thermococcales, Shiraishi, M,Ishono, S,Egashira, Y,Kiyonari, S,Yamagami, T,Cann, I,Ishino, Y, The 2016 Annual Conference of the Japan Society for Bioscience, Biotechnology and Agrochemistry, 2016/03
  • アーキアに見出された損傷塩基修復酵素Endonuclease Qの特性, 白石 都,石野園子,牧田成人,江頭由里子,清成信一,山上 健,石野良純, 第26回日本Archaea研究会, 2013/07
  • Identification of a novel repair endonuclease from the hyperthermophilic archaeon Pyrococcus furiosus, Shiraishi, M,Ishono, S,Makita, N,Egashira, Y,Kiyonari, S,Yamagami, T,Ishino, Y, Annual Meeting of 13th PSSJ, 2013/06
  • アーキアの損傷塩基除去修復に関わる新規酵素の発見, 白石 都,石野園子,牧田成人,江頭由里子,清成信一,山上 健,石野良純, 日本生化学会 九州支部例会, 2013/05

Committee Memberships

  • Frontiers in Microbiology (Biology of Archaea), Review Editor, 2019/07 - Present