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Hanashima Shinya

花島 慎弥

Associate Professor

keyword Organic synthesis,NMR,lipids, glycans

Education

  • 2000/04 - 2003/03, Tokyo University of Science, Graduate School of Science and Technology

Research History

  • 2020/10 - Present, Osaka University, Graduate School of Science Department of Chemistry
  • 2013/04 - 2020/09, Osaka University, Graduate School of Science Department of Chemistry
  • 2008/05 - 2013/03, 理化学研究所, 糖鎖構造生物学研究チーム, 研究員
  • 2007/04 - 2008/04, Kanagawa University, Faculty of Engineering, Department of Material and Life C
  • 2005/04 - 2007/03, スイス連邦大学(ETH), 学術振興会 海外特別研究員
  • 2003/04 - 2005/03, 理化学研究所, 基礎科学特別研究員

Research Areas

  • Life sciences, Biophysics
  • Life sciences, Bioorganic chemistry, lipids glycans
  • Nanotechnology/Materials, Molecular biochemistry

Professional Memberships

  • FCCA
  • THE CHEMICAL SOCIETY OF JAPAN
  • THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN
  • 日本糖質学会
  • 日本農芸化学会

Papers

  • FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers., Mikito Nakano,Shinya Hanashima,Toshiaki Hara,Kazuya Kabayama,Yuya Asahina,Hironobu Hojo,Naoko Komura,Hiromune Ando,Thomas K M Nyholm,J Peter Slotte,Michio Murata, Biochimica et biophysica acta. Biomembranes, Vol. 1863, No. 8, p. 183623-183623, 2021/08/01
  • Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with cholesterol., Joan Candice Ondevilla,Shinya Hanashima,Akane Mukogawa,Yuichi Umegawa,Michio Murata, Bioorganic & medicinal chemistry letters, Vol. 36, p. 127816-127816, 2021/03/15
  • Label‐Free Phase Change Detection of Lipid Bilayers Using Nanoscale Diamond Magnetometry, Hitoshi Ishiwata,Hiroshi C. Watanabe,Shinya Hanashima,Takayuki Iwasaki,Mutsuko Hatano, Advanced Quantum Technologies, Wiley, Vol. 4, No. 4, p. 2000106-2000106, 2021/02/19
  • β-Glucosylation of cholesterol reduces sterol-sphingomyelin interactions., Shinya Hanashima,Nanami Fukuda,Raymond Malabed,Michio Murata,Msanao Kinoshita,Peter Greimel,Yoshio Hirabayashi, Biochimica et biophysica acta. Biomembranes, p. 183496-183496, 2020/10/31
  • Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains., Yo Yano,Shinya Hanashima,Hiroshi Tsuchikawa,Tomokazu Yasuda,J Peter Slotte,Erwin London,Michio Murata, Biophysical journal, Vol. 119, No. 3, p. 539-552, 2020/08/04
  • Efficient preparation of human and mouse CD1d proteins using silkworm baculovirus expression system., Hiroki Kusaka,Shunsuke Kita,Takashi Tadokoro,Kouki Yoshida,Yoshiyuki Kasai,Harumi Niiyama,Yukari Fujimoto,Shinya Hanashima,Michio Murata,Shigeru Sugiyama,Toyoyuki Ose,Kimiko Kuroki,Katsumi Maenaka, Protein expression and purification, Vol. 172, p. 105631-105631, 2020/08
  • Discovery of a new sialic acid binding region that regulates Siglec-7., Nao Yamakawa,Yu Yasuda,Atsushi Yoshimura,Ami Goshima,Paul R Crocker,Gérard Vergoten,Yuji Nishiura,Takashi Takahashi,Shinya Hanashima,Kana Matsumoto,Yoshiki Yamaguchi,Hiroshi Tanaka,Ken Kitajima,Chihiro Sato, Scientific reports, Vol. 10, No. 1, p. 8647-8647, 2020/05/26
  • Efficient diversification of GM3 gangliosides via late-stage sialylation and dynamic glycan structural studies with 19F solid-state NMR., Maina Takahashi,Junya Shirasaki,Naoko Komura,Katsuaki Sasaki,Hide-Nori Tanaka,Akihiro Imamura,Hideharu Ishida,Shinya Hanashima,Michio Murata,Hiromune Ando, Organic & biomolecular chemistry, Vol. 18, No. 15, p. 2902-2913, 2020/04/15
  • Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin., Raymond Malabed,Shinya Hanashima,Michio Murata,Kaori Sakurai, Langmuir : the ACS journal of surfaces and colloids, 2020/03/30
  • Enantiomers of phospholipids and cholesterol: A key to decipher lipid-lipid interplay in membrane., Shinya Hanashima,Yo Yano,Michio Murata, Chirality, Vol. 32, No. 3, p. 282-298, 2020/03
  • The Amphotericin B–Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly, Tomoya Yamamoto,Yuichi Umegawa,Hiroshi Tsuchikawa,Shinya Hanashima,Nobuaki Matsumori,Kosuke Funahashi,Sangjae Seo,Wataru Shinoda,Michio Murata, Biochemistry, American Chemical Society ({ACS}), Vol. 58, No. 51, p. 5188-5196, 2019/12/24
  • The Core Fucose on an IgG Antibody is an Endogenous Ligand of Dectin-1, Yoshiyuki Manabe,Roberta Marchetti,Yohei Takakura,Masahiro Nagasaki,Wataru Nihei,Tomoyuki Takebe,Katsunori Tanaka,Kazuya Kabayama,Fabrizio Chiodo,Shinya Hanashima,Yoshihiro Kamada,Eiji Miyoshi,Hari Prasad Dulal,Yoshiki Yamaguchi,Yoshiyuki Adachi,Naohito Ohno,Hiroshi Tanaka,Alba Silipo,Koichi Fukase,Antonio Molinaro, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, Vol. 58, No. 51, p. 18697-18702, 2019/12
  • Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning, Hanashima Shinya,Ibata Yuki,Watanabe Hirofumi,Yasuda Tomokazu,Tsuchikawa Hiroshi,Murata Michio, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 17, No. 37, p. 8601-8610, 2019/10/07
  • 酸性糖脂質とインスリン受容体の膜貫通ペプチドの静電的相互作用の解析(Analysis of electrostatic interaction of acidic glycolipid with transmembrane peptide of insulin receptor), Nimura Yuka,Kabayama Kazuya,Asahina Yuya,Hanashima Shinya,Hojo Hironobu,Murata Michio,Fukase Koichi, 生物物理, (一社)日本生物物理学会, Vol. 59, No. Suppl.1-2, p. S411-S411, 2019/08
  • Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup, Shinya Hanashima,Kazuhiro Murakami,Michihiro Yura,Yo Yano,Yuichi Umegawa,Hiroshi Tsuchikawa,Nobuaki Matsumori,Sangjae Seo,Wataru Shinoda,Michio Murata, Biophysical Journal, Elsevier {BV}, Vol. 117, No. 2, p. 307-318, 2019/07
  • NMR Study of Glycan Interactions Using Synthetic Oligosaccharides, Hanashima Shinya, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, Vol. 31, No. 181, p. SE67-SE68, 2019/07
  • The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model., Yamamoto T,Umegawa Y,Yamagami M,Suzuki T,Tsuchikawa H,Hanashima S,Matsumori N,Murata M, Biochemistry, Vol. 58, No. 17, p. 2282-2291, 2019/04/30
  • Synthesis of Core Oligosaccharides of Lipooligosaccharides from Campylobacter jejuni, a Putative Cause of Guillain-Barré Syndrome., Yoshida F,Yoshinaka H,Tanaka H,Hanashima S,Yamaguchi Y,Ishihara M,Saburomaru M,Kato Y,Saito R,Ando H,Kiso M,Imamura A,Ishida H, Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 25, No. 3, p. 796-805, 2018/10
  • Sphingomyelin Stereoisomers Reveal That Homophilic Interactions Cause Nanodomain Formation., Yano Y,Hanashima S,Yasuda T,Tsuchikawa H,Matsumori N,Kinoshita M,Al Sazzad MA,Slotte JP,Murata M, Biophysical journal, Elsevier BV, Vol. 115, No. 8, p. 1530-1540, 2018/09
  • Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V., Masamichi Nagae,Yasuhiko Kizuka,Emiko Mihara,Yu Kitago,Shinya Hanashima,Yukishige Ito,Junichi Takagi,Naoyuki Taniguchi,Yoshiki Yamaguchi, Nature communications, Vol. 9, No. 1, p. 3380-3380, 2018/08/23
  • Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol., Cornelio K,Espiritu RA,Hanashima S,Todokoro Y,Malabed R,Kinoshita M,Matsumori N,Murata M,Nishimura S,Kakeya H,Yoshida M,Matsunaga S, Biochimica et biophysica acta. Biomembranes, Elsevier BV, Vol. 1861, No. 1, p. 228-235, 2018/07
  • Molecular basis for diversification of yeast prion strain conformation, Ohhashi, Yumiko,Yamaguchi, Yoshiki,Kurahashi, Hiroshi,Kamatari, Yuji O.,Sugiyama, Shinju,Uluca, Boran,Piechatzek, Timo,Komi, Yusuke,Shida, Toshinobu,Mueller, Henrik,Hanashima, Shinya,Heise, Henrike,Kuwata, Kazuo,Tanaka, Motomasa, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 115, No. 10, p. 2389-2394, 2018/03
  • Bisecting GlcNAc restricts conformations of branches in model N-glycans with GlcNAc termini, Shinya Hanashima,Akitsugu Suga,Yoshiki Yamaguchi, Carbohydrate Research, Elsevier Ltd, Vol. 456, p. 53-60, 2018/02/01
  • Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins, Raymond Malabed,Shinya Hanashima,Michio Murata,Kaori Sakurai, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, ELSEVIER SCIENCE BV, Vol. 1859, No. 12, p. 2516-2525, 2017/12
  • Distinct roles for each N-glycan branch interacting with mannose-binding type Jacalin-related lectins Orysata and Calsepa., Masamichi Nagae,Sushil K Mishra,Shinya Hanashima,Hiroaki Tateno,Yoshiki Yamaguchi, Glycobiology, Vol. 27, No. 12, p. 1120-1133, 2017/12/01
  • Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure-Activity Relationships, Masayuki Satake,Kimberly Cornelio,Shinya Hanashima,Raymond Malabed,Michio Murata,Nobuaki Matsumori,Huiping Zhang,Fumiaki Hayashi,Shoko Mori,Jong Souk Kim,Chang-Hoon Kim,Jong-Soo Lee, JOURNAL OF NATURAL PRODUCTS, AMER CHEMICAL SOC, Vol. 80, No. 11, p. 2883-2888, 2017/11
  • Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent, Takanori Nakane,Shinya Hanashima,Mamoru Suzuki,Haruka Saiki,Taichi Hayashi,Keisuke Kakinouchi,Shigeru Sugiyama,Satoshi Kawatake,Shigeru Matsuoka,Nobuaki Matsumori,Eriko Nango,Jun Kobayashi,Tatsuro Shimamura,Kanako Kimura,Chihiro Mori,Naoki Kunishima,Michihiro Sugahara,Yoko Takakyu,Shigeyuki Inoue,Tetsuya Masuda,Toshiaki Hosaka,Kensuke Tono,Yasumasa Joti,Takashi Kameshima,Takaki Hatsui,Makina Yabashi,Tsuyoshi Inoue,Osamu Nureki,So Iwata,Michio Murata,Eiichi Mizohata, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, No. 46, p. 13039-13044, 2016/11
  • Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by H-1 NMR, Kimberly Cornelio,Rafael Atillo Espiritu,Yasuto Todokoro,Shinya Hanashima,Masanao Kinoshita,Nobuaki Matsumori,Michio Murata,Shinichi Nishimura,Hideaki Kakeya,Minoru Yoshida,Shigeki Matsunaga, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 24, No. 21, p. 5235-5242, 2016/11
  • Synthesis and Th1-immunostimulatory activity of alpha-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain, Md. Imran Hossain,Shinya Hanashima,Takuto Nomura,Sebastien Lethu,Hiroshi Tsuchikawa,Michio Murata,Hiroki Kusaka,Shunsuke Kita,Katsumi Maenaka, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 24, No. 16, p. 3687-3695, 2016/08
  • The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores, Yasuo Nakagawa,Yuichi Umegawa,Naohiro Matsushita,Tomoya Yamamoto,Hiroshi Tsuchikawa,Shinya Hanashima,Tohru Oishi,Nobuaki Matsumori,Michio Murata, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 55, No. 24, p. 3392-3402, 2016/06
  • Crystal structure of human dendritic cell inhibitory receptor C-type lectin domain reveals the binding mode with N-glycan (vol 590, pg 1280, 2016), Masamichi Nagae,Akemi Ikeda,Shinya Hanashima,Takumi Kojima,Naoki Matsumoto,Kazuo Yamamoto,Yoshiki Yamaguchi, FEBS LETTERS, WILEY-BLACKWELL, Vol. 590, No. 10, p. 1552-1552, 2016/05
  • Crystal structure of human dendritic cell inhibitory receptor C-type lectin domain reveals the binding mode with N-glycan, Masamichi Nagae,Akemi Ikeda,Shinya Hanashima,Takumi Kojima,Naoki Matsumoto,Kazuo Yamamoto,Yoshiki Yamaguchi, FEBS LETTERS, WILEY-BLACKWELL, Vol. 590, No. 8, p. 1280-1288, 2016/04
  • Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins, Masamichi Nagae,Mayumi Kanagawa,Kana Morita-Matsumoto,Shinya Hanashima,Yasuhiko Kizuka,Naoyuki Taniguchi,Yoshiki Yamaguchi, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 6, 2016/03
  • Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane, Tomoya Yamamoto,Yuichi Umegawa,Hiroshi Tsuchikawa,Nobuaki Matsumori,Shinya Hanashima,Michio Murata,Resul Haser,Bernard J. Rawlings,Patrick Caffrey, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 23, No. 17, p. 5782-5788, 2015/09
  • Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides, Shinya Hanashima,Sebastian Goetze,Yan Liu,Akemi Ikeda,Kyoko Kojima-Aikawa,Naoyuki Taniguchi,Daniel Varon Silva,Ten Feizi,Peter H. Seeberger,Yoshiki Yamaguchi, CHEMBIOCHEM, WILEY-V C H VERLAG GMBH, Vol. 16, No. 10, p. 1502-1511, 2015/07
  • Axial Hydrogen at C7 Position and Bumpy Tetracyclic Core Markedly Reduce Sterol's Affinity to Amphotericin B in Membrane, Yasuo Nakagawa,Yuichi Umegawa,Kenichi Nonomura,Naohiro Matsushita,Tetsuro Takano,Hiroshi Tsuchikawa,Shinya Hanashima,Tohru Oishi,Nobuaki Matsumori,Michio Murata, BIOCHEMISTRY, AMER CHEMICAL SOC, Vol. 54, No. 2, p. 303-312, 2015/01
  • NMR interaction analysis of intestinal soluble lectin ZG16p with mycobacterium phosphatidylinositol mannosides, Shinya Hanashima,Mayumi Kanagawa,Sebastian Goetze,Yan Liu,Akemi Ikeda,Daniel Varon Silva,Ten Feizi,Peter Seeberger,Yoshiki Yamaguchi, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 24, No. 11, p. 1133-1134, 2014/11
  • Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel, Ambara R. Pradipta,Ayumi Tsutsui,Akihiro Ogura,Shinya Hanashima,Yoshiki Yamaguchi,Almira Kurbangalieva,Katsunori Tanaka, SYNLETT, GEORG THIEME VERLAG KG, Vol. 25, No. 17, p. 2442-2446, 2014/10
  • Stabilization of beta-peptide helices by direct attachment of trifluoromethyl groups to peptide backbones, Joonil Cho,Kyohei Sawaki,Shinya Hanashima,Yoshiki Yamaguchi,Motoo Shiro,Kazuhiko Saigo,Yasuhiro Ishida, CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, Vol. 50, No. 69, p. 9855-9858, 2014/09
  • Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III, Shinya Hanashima,Hiroaki Korekane,Naoyuki Taniguchi,Yoshiki Yamaguchi, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 24, No. 18, p. 4533-4537, 2014/09
  • Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin, Mayumi Kanagawa,Yan Liu,Shinya Hanashima,Akemi Ikeda,Wengang Chai,Yukiko Nakano,Kyoko Kojima-Aikawa,Ten Feizi,Yoshiki Yamaguchi, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 289, No. 24, p. 16954-16965, 2014/06
  • Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold, Masamichi Nagae,Keisuke Soga,Kana Morita-Matsumoto,Shinya Hanashima,Akemi Ikeda,Kazuo Yamamoto,Yoshiki Yamaguchi, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 24, No. 4, p. 368-378, 2014/04
  • NMR study of short β(1-3)-glucans provides insights into the structure and interaction with Dectin-1., Shinya Hanashima,Akemi Ikeda,Hiroshi Tanaka,Yoshiyuki Adachi,Naohito Ohno,Takashi Takahashi,Yoshiki Yamaguchi, Glycoconjugate journal, Vol. 31, No. 3, p. 199-207, 2014/04
  • ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein ( HOP)*, Soh Yamamoto,Ganesh Prasad Subedi,Shinya Hanashima,Tadashi Satoh,Michiro Otaka,Hideki Wakui,Ken-ichi Sawada,Shin-ichi Yokota,Yoshiki Yamaguchi,Hiroshi Kubota,Hideaki Itoh, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 289, No. 14, p. 9880-9886, 2014/04
  • Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress, Ayumi Tsutsui,Rie Imamaki,Shinobu Kitazume,Shinya Hanashima,Yoshiki Yamaguchi,Masato Kaneda,Shinya Oishi,Nobutaka Fujii,Almira Kurbangalieva,Naoyuki Taniguchi,Katsunori Tanaka, ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOC CHEMISTRY, Vol. 12, No. 28, p. 5151-5157, 2014
  • Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: insight into the binding preference for polysialic acid., Masamichi Nagae,Akemi Ikeda,Masaya Hane,Shinya Hanashima,Ken Kitajima,Chihiro Sato,Yoshiki Yamaguchi, The Journal of biological chemistry, Vol. 288, No. 47, p. 33784-96, 2013/11/22
  • Recognition of Bisecting N-Acetylglucosamine STRUCTURAL BASIS FOR ASYMMETRIC INTERACTION WITH THE MOUSE LECTIN DENDRITIC CELL INHIBITORY RECEPTOR 2, Masamichi Nagae,Kousuke Yamanaka,Shinya Hanashima,Akemi Ikeda,Kana Morita-Matsumoto,Tadashi Satoh,Naoki Matsumoto,Kazuo Yamamoto,Yoshiki Yamaguchi, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 288, No. 47, p. 33598-33610, 2013/11
  • Difucosylation of chitooligosaccharides by eukaryote and prokaryote α1,6-fucosyltransferases., Ihara H,Hanashima S,Tsukamoto H,Yamaguchi Y,Taniguchi N,Ikeda Y, Biochimica et biophysica acta, Vol. 1830, No. 10, p. 4482-4490, 2013/10
  • Difucosylation of chitooligosaccharides by eukaryote and prokaryote alpha 1,6-fucosyltransferases, Ihara Hideyuki,Hanashima Shinya,Tsukamoto Hiroki,Yamaguchi Yoshiki,Taniguchi Naoyuki,Ikeda Yoshitaka, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Vol. 1830, No. 10, p. 4482-4490, 2013/10
  • NMR study into the mechanism of recognition of the degree of polymerization by oligo/polysialic acid antibodies, Shinya Hanashima,Chihiro Sato,Hiroshi Tanaka,Takashi Takahashi,Ken Kitajima,Yoshiki Yamaguchi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 21, No. 19, p. 6069-6076, 2013/10
  • 溶液酸素NMRによる酸化修飾タンパク質の新規検出方法, 藤原 範子,花島 慎弥,山口 芳樹,鄭 国慶,鳥越 秀峰,谷口 直之,鈴木 敬一郎, 日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, Vol. 86回, p. 1P-104, 2013/09
  • Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb), Hiroaki Korekane,Jong Yi Park,Akio Matsumoto,Kazuki Nakajima,Shinji Takamatsu,Kazuaki Ohtsubo,Yasuhide Miyamoto,Shinya Hanashima,Kenji Kanekiyo,Shinobu Kitazume,Yoshiki Yamaguchi,Ichiro Matsuo,Naoyuki Taniguchi, JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Vol. 288, No. 39, p. 27912-27926, 2013/09
  • Applications of NMR to Biomolecular Systems of Interactions: An Overview, Shinya Hanashima,Yoshiki Yamaguchi, Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences, Blackwell Publishing Ltd., Vol. PART6, No. Chapter 34, p. 573-591, 2013/01/04
  • Structural property of β-glucans and the recognition by β-glucan binding proteins, Kanagawa, M,Hanashima, S,Yamaguchi, Y, 実験医学, Vol. 31, No. 10, 2013
  • A solution O-17-NMR approach for observing an oxidized cysteine residue in Cu,Zn-superoxide dismutase, Shinya Hanashima,Noriko Fujiwara,Kana Matsumoto,Noriyuki Iwasaki,Guo-qing Zheng,Hidetaka Torigoe,Keiichiro Suzuki,Naoyuki Taniguchi,Yoshiki Yamaguchi, CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, Vol. 49, No. 14, p. 1449-1451, 2013
  • NMR Conformational Analysis of alpha(2-8)Oligo- and Polysialic Acids, Shinya Hanashima, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, GAKUSHIN PUBL CO, Vol. 24, No. 139, p. 228-230, 2012/09
  • Synthesis of β(1,3) oligoglucans exhibiting a Dectin-1 binding affinity and their biological evaluation., Hiroshi Tanaka,Tetsuya Kawai,Yoshiyuki Adachi,Shinya Hanashima,Yoshiki Yamaguchi,Naohito Ohno,Takashi Takahashi, Bioorganic & medicinal chemistry, Vol. 20, No. 12, p. 3898-914, 2012/06/15
  • Overproduction of anti-Tn antibody MLS128 single-chain Fv fragment in Escherichia coli cytoplasm using a novel pCold-PDI vector, Ganesh P. Subedi,Tadashi Satoh,Shinya Hanashima,Akemi Ikeda,Hiroshi Nakada,Reiko Sato,Mamoru Mizuno,Noriyuki Yuasa,Yoko Fujita-Yamaguchi,Yoshiki Yamaguchi, PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 82, No. 1, p. 197-204, 2012/03
  • Surface plasmon resonance and NMR analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three consecutive Tn-antigen clusters, Ayano Matsumoto-Takasaki,Shinya Hanashima,Ami Aoki,Noriyuki Yuasa,Haruhiko Ogawa,Reiko Sato,Hiroko Kawakami,Mamoru Mizuno,Hiroshi Nakada,Yoshiki Yamaguchi,Yoko Fujita-Yamaguchi, JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, Vol. 151, No. 3, p. 273-282, 2012/03
  • NMR Analysis of an Anti-Carbohydrate Antibody MLS128 Single-Chain Fv Fragment toward Elucidation of the Multivalent Recognition Mechanism, Ganesh Prasad Subedi,Tadashi Satoh,Shinya Hanashima,Akemi Ikeda,Hiroshi Nakada,Reiko Sato,Mamoru Mizuno,Noriyuki Yuasa,Yoko Fujita-Yamaguchi,Yoshiki Yamaguchi, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 21, No. 11, p. 1480-1480, 2011/11
  • Recent Strategies for Stereoselective Sialylation and Their Application to the Synthesis of Oligosialosides, Shinya Hanashima, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, GAKUSHIN PUBL CO, Vol. 23, No. 131, p. 111-121, 2011/05
  • C-13-NMR quantification of proton exchange at LewisX hydroxyl groups in water, Shinya Hanashima,Koichi Kato,Yoshiki Yamaguchi, CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, Vol. 47, No. 38, p. 10800-10802, 2011
  • Structural Basis for Oligosaccharide Recognition of Misfolded Glycoproteins by OS-9 in ER-Associated Degradation, Tadashi Satoh,Yang Chen,Dan Hu,Shinya Hanashima,Kazuo Yamamoto,Yoshiki Yamaguchi, MOLECULAR CELL, CELL PRESS, Vol. 40, No. 6, p. 905-916, 2010/12
  • Fucosylation of chitooligosaccharides by human alpha 1,6-fucosyltransferase requires a nonreducing terminal chitotriose unit as a minimal structure, Hideyuki Ihara,Shinya Hanashima,Takahiro Okada,Ritsu Ito,Yoshiki Yamaguchi,Naoyuki Taniguchi,Yoshitaka Ikeda, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 20, No. 8, p. 1021-1033, 2010/08
  • Analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three consecutive Tn-antigen clusters by surface plasmon resonance (SPR) and NMR, Ayano Takasaki-Matsumoto,Shinya Hanashima,Ami Aoki,Yoshiki Yamaguchi,Reiko Sato,Hiroko Kawakami,Mamoru Mizuno,Yoko Fujita-Yamaguchi, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, Vol. 240, 2010/08
  • Chemoselective Ligation of the Glycosylphosphatidylinositol-Anchor with the Target Protein: Toward Total Synthesis of the Glycosylphosphatidylinositol-Anchored Protein, Shinya Hanashima, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, GAKUSHIN PUBL CO, Vol. 22, No. 126-28, p. 308-310, 2010/07
  • Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques, Shinya Hanashima,Ken-ichi Sato,Yuko Naito,Hiromu Takematsu,Yasunori Kozutsumi,Yukishige Ito,Yoshiki Yamaguchi, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 18, No. 11, p. 3720-3725, 2010/06
  • NMR characterization of intramolecular interaction of osteopontin, an intrinsically disordered protein with cryptic integrin-binding motifs., Yoshiki Yamaguchi,Shinya Hanashima,Hirokazu Yagi,Yutaka Takahashi,Hiroaki Sasakawa,Eiji Kurimoto,Takeshi Iguchi,Shigeyuki Kon,Toshimitsu Uede,Koichi Kato, Biochemical and biophysical research communications, Vol. 393, No. 3, p. 487-91, 2010/03/12
  • NMR characterization of intramolecular interaction of osteopontin, an intrinsically disordered protein with cryptic integrin-binding motifs, Yoshiki Yamaguchi,Shinya Hanashima,Hirokazu Yagi,Yutaka Takahashi,Hiroaki Sasakawa,Eiji Kurimoto,Takeshi Iguchi,Shigeyuki Kon,Toshimitsu Uede,Koichi Kato, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 393, No. 3, p. 487-491, 2010/03
  • Characterization of Inhibitor-Bound alpha-Synuclein Dimer: Role of alpha-Synuclein N-Terminal Region in Dimerization and Inhibitor Binding, Yoshiki Yamaguchi,Masami Masuda,Hiroaki Sasakawa,Takashi Nonaka,Shinya Hanashima,Shin-ichi Hisanaga,Koichi Kato,Masato Hasegawa, JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, Vol. 395, No. 3, p. 445-456, 2010/01
  • Synthesis of the starfish ganglioside AG2 pentasaccharide, Shinya Hanashima,Yoshiki Yamaguchi,Yukishige Ito,Ken-ichi Sato, TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 50, No. 45, p. 6150-6153, 2009/11
  • Crystallographic Study of Human OS-9 Involved in ER-Associated Degradation, Tadashi Satoh,Shinya Hanashima,Kazuo Yamamoto,Yoshiki Yamaguchi, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 19, No. 11, p. 1372-1372, 2009/11
  • Silyiene/Oxazolidinone Double-Locked Sialic Acid Building Blocks for Efficient Sialylation Reactions in Dichloromethane, Shinya Hanashima,Ken-ichi Sato,Yukishige Ito,Yoshiki Yamaguchi, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, No. 25, p. 4215-4220, 2009/09
  • Homogeneous glycoprotein synthesis using bacterial oligosaccharyltransferase, Shinya Hanashima, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, GAKUSHIN PUBL CO, Vol. 21, No. 121, p. 302-304, 2009/09
  • Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans, Shinya Hanashima,Taku Tomiya,Daichi Ishikawa,Shoji Akai,Ken-ichi Sato, CARBOHYDRATE RESEARCH, ELSEVIER SCI LTD, Vol. 344, No. 8, p. 959-965, 2009/05
  • Synthesis of the starfish ganglioside LLG-3 tetrasaccharide, Shinya Hanashima,Daichi Ishikawa,Shoji Akai,Ken-ichi Sato, CARBOHYDRATE RESEARCH, ELSEVIER SCI LTD, Vol. 344, No. 6, p. 747-752, 2009/04
  • Development of an NMR Method for Structural Analysis of Oligosaccharides, Yoshiki Yamaguchi,Shinya Hanashima,Masaki Kato,Koichi Kato, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 18, No. 11, p. 971-971, 2008/11
  • Thioester-assisted alpha-sialylation reaction, Shinya Hanashima,Shoji Akai,Ken-ichi Sato, TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 49, No. 34, p. 5111-5114, 2008/08
  • Synthesis of a sialic acid alpha(2-3) galactose building block and its use in a linear synthesis of sialyl Lewis X, Shinya Hanashima,Bastien Castagner,Davide Esposito,Toshiki Nokami,Peter H. Seeberger, ORGANIC LETTERS, AMER CHEMICAL SOC, Vol. 9, No. 9, p. 1777-1779, 2007/04
  • Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53, Hiroshi Iijima,Nobuyuki Kasai,Hiroyuki Chiku,Toshifumi Takeuchi,Kouji Kuramochi,Shinya Hanashima,Susumu Kobayashi,Fumio Sugawara,Kengo Sakaguchi,Hiromi Yoshida,Yoshiyuki Mizushina, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, PROFESSOR D A SPANDIDOS, Vol. 19, No. 1, p. 41-48, 2007/01
  • Total synthesis of sialylated Glycans related to avian and human influenza virus infection, Shinya Hanashima,Peter H. Seeberger, CHEMISTRY-AN ASIAN JOURNAL, WILEY-V C H VERLAG GMBH, Vol. 2, No. 11, p. 1447-1459, 2007
  • Systematic synthesis of bisubstrate-type inhibitors of N-acetylglucosaminyltransferases, S Hanashima,KI Inamori,S Manabe,N Taniguchi,Y Ito, CHEMISTRY-A EUROPEAN JOURNAL, WILEY-V C H VERLAG GMBH, Vol. 12, No. 13, p. 3449-3462, 2006/04
  • Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies, S Hanashima,S Manabe,Y Ito, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, Vol. 44, No. 27, p. 4218-4224, 2005
  • Synthesis of a bisubstrate-type inhibitor of N-acetylglucosaminyltransferases, S Hanashima,S Manabe,K Inamori,N Taniguchi,Y Ito, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, Vol. 43, No. 42, p. 5674-5677, 2004
  • Polymer-resin hybrid capture-release strategy for rapid oligosaccharide construction, S Hanashima,S Manabe,Y Ito, SYNLETT, GEORG THIEME VERLAG KG, No. 7, p. 979-982, 2003/06
  • A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid, C Murakami,T Yamazaki,S Hanashima,S Takahashi,M Takemura,S Yoshida,K Ohta,H Yoshida,F Sugawara,K Sakaguchi,Y Mizushina, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, ELSEVIER SCIENCE BV, Vol. 1645, No. 1, p. 72-80, 2003/01
  • An immunosuppressive effect by synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin, Y Matsumoto,H Sahara,T Fujita,K Shimozawa,M Takenouchi,T Torigoe,S Hanashima,T Yamazaki,S Takahashi,F Sugawara,Y Mizushina,K Ohta,N Takahashi,S Gasa,K Jimbow,K Sakaguchi,N Sato, TRANSPLANTATION, LIPPINCOTT WILLIAMS & WILKINS, Vol. 74, No. 2, p. 261-267, 2002/07
  • Structure-function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors, C Murakami,T Yamazaki,S Hanashima,S Takahashi,K Ohta,H Yoshida,F Sugawara,K Sakaguchi,Y Mizushina, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 403, No. 2, p. 229-236, 2002/07
  • Biotinylated lithocholic acids for affinity chromatography of mammalian DNA polymerases alpha and beta, M Watanabe,S Hanashima,Y Mizushina,H Yoshida,M Oshige,K Sakaguchi,F Sugawara, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 12, No. 3, p. 287-290, 2002/02
  • Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols, H Sahara,S Hanashima,T Yamazaki,S Takahashi,F Sugawara,S Ohtani,M Ishikawa,Y Mizushina,K Ohta,K Shimozawa,S Gasa,K Jimbow,K Sakaguchi,N Sato,N Takahashi, JAPANESE JOURNAL OF CANCER RESEARCH, BUSINESS CENTER ACADEMIC SOCIETIES JAPAN, Vol. 93, No. 1, p. 85-92, 2002/01
  • Specific interaction between an oligosaccharide on the tumor cell surface and the novel antitumor agents, sulfoquinovosylacylglycerols, K Ohta,Y Mizushina,T Yamazaki,S Hanashima,F Sugawara,K Sakaguchi, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, Vol. 288, No. 4, p. 893-900, 2001/11
  • Galactosyldiacylglycerol, a mammalian DNA polymerase alpha-specific inhibitor from a sea alga, Petalonia bingbamiae, Y Mizushina,Y Sugiyama,H Yoshida,S Hanashima,T Yamazaki,S Kamisuki,K Ohta,M Takemura,T Yamaguchi,A Matsukage,S Yoshida,M Saneyoshi,F Sugawara,K Sakagauchi, BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, Vol. 24, No. 9, p. 982-987, 2001/09
  • Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta, S Hanashima,Y Mizushima,T Yamazaki,K Ohta,S Takahashi,H Sahara,K Sakaguchi,F Sugawara, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 9, No. 2, p. 367-376, 2001/02
  • A novel immunosuppressive agent, SQDG, derived from sea urchin, Y Matsumoto,H Sahara,T Fujita,S Hanashima,T Yamazaki,S Takahashi,F Sugawara,Y Mizushina,K Ohta,N Takahashi,K Jimbow,K Sakaguchi,N Sato, TRANSPLANTATION PROCEEDINGS, ELSEVIER SCIENCE INC, Vol. 32, No. 7, p. 2051-2053, 2000/11
  • Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols, S Hanashima,Y Mizushina,K Ohta,T Yamazaki,F Sugawara,K Sakaguchi, JAPANESE JOURNAL OF CANCER RESEARCH, BUSINESS CENTER ACADEMIC SOCIETIES JAPAN, Vol. 91, No. 10, p. 1073-1083, 2000/10
  • Structural determination of sulfoquinovosyldiacylglycerol by chiral syntheses, S Hanashima,Y Mizushina,T Yamazaki,K Ohta,S Takahashi,H Koshino,H Sahara,K Sakaguchi,F Sugawara, TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, Vol. 41, No. 22, p. 4403-4407, 2000/06
  • Studies on a novel DNA polymerase inhibitor group, synthetic sulfoquinovosylacylglycerols: inhibitory action on cell proliferation, K Ohta,S Hanashima,Y Mizushina,T Yamazaki,M Saneyoshi,F Sugawara,K Sakaguchi, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, ELSEVIER SCIENCE BV, Vol. 467, No. 2, p. 139-152, 2000/05

Misc.

  • FRET analysis for the sphingolipid domains in model bilayer membranes using the fluorescent sphingolipid probes, 友田千尋,矢野陽,花島慎弥,河村奈緒子,安藤弘宗,村田道雄,LONDON Erwin, 日本化学会春季年会講演予稿集(Web), Vol. 101st, 2021
  • Quantitative Analysis of Lipid Composition of L<sub>o</sub>/L<sub>d</sub> Phase in Phase-Separated Membrane Using Deuterium Solid-state NMR, 山中彩菜,花島慎弥,井端悠貴,梅川雄一,村田道雄, 日本化学会春季年会講演予稿集(Web), Vol. 101st, 2021
  • Cholesterol Distribution in The Inner and Outer Leaflets of Asymmetric Bilayer Membranes, 渡辺宏史,花島慎弥,村田道雄, 日本化学会春季年会講演予稿集(Web), Vol. 101st, 2021
  • Evaluation of membrane functions of polyunsaturated fatty acid-substituted phospholipids based on solid-state-NMR, 大田英和,梅川雄一,花島慎弥,土川博史,村田道雄, 日本化学会春季年会講演予稿集(Web), Vol. 101st, 2021
  • Evaluation of lateral interactions between membrane gangliosides and receptor transmembrane segments in lipid bilayers based on semi-quantitative fluorescence analysis, NAKANO Mikito,HANASHIMA Shinya,HARA Toshiaki,KABAYAMA Kazuya,FUKASE Koichi,MURATA Michio,ANDO Hiromune,SUZUKI Kenichi G. N.,SLOTTE J. Peter, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 100th, 2020
  • Evaluation of the Glycosylation Effect on the Interaction of Cholesteryl Glucoside with Membrane Lipids, 花島慎弥,福田奈那美,MALABED Raymond,村田道雄,木下祥尚,GREIMEL Peter,平林義雄,平林義雄, 日本糖質学会年会要旨集, Vol. 39th, 2020
  • Identification of core fucose containing N-glycan recognition lectin., 真鍋良幸,真鍋良幸,MARCHETTI Roberta,高倉陽平,長崎政裕,二瓶渉,武部智之,田中克典,田中克典,樺山一哉,樺山一哉,CHIODO Fabrizio,花島慎弥,鎌田佳宏,三善英知,DULAL Hari Prasad,山口芳樹,安達禎之,大野尚仁,田中浩士,SILIPO Alba,MOLINARO Antonio,MOLINARO Antonio,深瀬浩一,深瀬浩一, 日本糖質学会年会要旨集, Vol. 39th, 2020
  • CD1dとアミド基導入抗原複合体のX線結晶構造解析, 喜多 俊介,日下 裕規,井貫 晋輔,Md. Imran Hossain,花島 慎弥,田所 高志,新山 真由美,杉山 成,相羽 俊彦,尾瀬 農之,黒木 喜美子,深瀬 浩一,村田 道雄,藤本 ゆかり,前仲 勝実, 日本結晶学会 講演要旨集, 2019/11
  • Analysis of electrostatic interaction between ganglioside GM3 and transmembrane peptide, Yuka Nimura,Kazuya Kabayama,Yuya Asahina,Shinya Hanashima,Hironobu Hojo,Michio Murata,Koichi Fukase, AIP Conference Proceedings, AMER INST PHYSICS, Vol. 2067, 2019/01/24
  • Analysis of electrostatic interaction of acidic glycolipid with transmembrane peptide of insulin receptor, NIMURA Yuka,KABAYAMA Kazuya,ASAHINA Yuya,HANASHIMA Shinya,HOJO Hironobu,MURATA Michio,FUKASE Koichi, 生物物理(Web), Vol. 59, No. Supplement 1-2, 2019
  • Interaction of ganglioside to the EGF receptor transmembrane segments in model membrane, NAKANO Mikito,HANASHIMA Shinya,HARA Toshiaki,MURATA Michio,KABAYAMA Kazuya,FUKASE Koichi,ANDO Hiromune,SUZUKI Kenichi,SLOTTE J. Peter, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 99th, 2019
  • Analysis of Electrostatic Interaction of Transmembrane Peptide of Insulin Receptor with Ganglioside GM3, NIMURA Yuka,KABAYAMA Kazuya,ASAHINA Yuya,HANASHIMA Shinya,HOJO Hironobu,MURATA Michio,FUKASE Koichi, Peptide Science, Vol. 2018, 2019
  • 膜貫通ペプチドを用いたインスリン受容体とガングリオシドGM3の静電的相互作用解析, 二村友香,樺山一哉,樺山一哉,樺山一哉,朝比奈雄也,花島慎弥,北條裕信,村田道雄,深瀬浩一,深瀬浩一,深瀬浩一, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 99th, 2019
  • NMR Study of Glycan Interactions Using Synthetic Oligosaccharides, 花島慎弥, Trends in Glycoscience and Glycotechnology (Web), Vol. 31, No. 181, 2019
  • スフィンゴ糖脂質の脂質間相互作用とエクソソーム膜物性の解析, 花島慎弥,矢野陽,安田智一,村田道雄, 日本生化学会大会(Web), Vol. 92nd, 2019
  • 癌化に関連する糖転移酵素GnT‐Vの結晶構造解析, 長江雅倫,長江雅倫,木塚康彦,木塚康彦,三原恵美子,北郷悠,花島慎弥,伊藤幸成,高木淳一,谷口直之,山口芳樹, 日本糖質学会年会要旨集, Vol. 37th, 2018/08/20
  • Ganglioside GM3 suppresses the oligomerization of EGFR TM domain in lipid bilayers, NAKANO Mikito,HANASHIMA Shinya,HARA Toshiaki,MURATA Michio,KABAYAMA Kazuya,FUKASE Koichi,ANDO Hiromune,SUZUKI Kenichi,SLOTTE J. Peter, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 98th, 2018
  • 酸性糖脂質とインスリン受容体の膜貫通ペプチドの静電的相互作用解析, 二村友香,樺山一哉,樺山一哉,樺山一哉,朝比奈雄也,花島慎弥,北條裕信,村田道雄,深瀬浩一,深瀬浩一,深瀬浩一, 日本分子生物学会年会プログラム・要旨集(Web), Vol. 41st, 2018
  • 生体モデル膜中におけるグルコシルセラミド頭部の固体NMR配向解析, 石井亮,花島慎弥,梅川雄一,村田道雄, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 98th, 2018
  • がん悪性化を促進する糖転移酵素GnT-VのX線結晶構造解析, 長江雅倫,木塚康彦,三原恵美子,北郷悠,花島慎弥,伊藤幸成,高木淳一,谷口直之,山口芳樹, 日本結晶学会年会講演要旨集, Vol. 2018, 2018
  • 脂質抗原提示分子CD1dによる抗原認識における種差, 日下裕規,喜多俊介,HOSSAIN Imran,花島慎弥,井貫晋輔,新山真由美,杉山成,相羽俊彦,尾瀬農之,黒木喜美子,深瀬浩一,藤本ゆかり,村田道雄,前仲勝実, 日本蛋白質科学会年会プログラム・要旨集, Vol. 18th, 2018
  • ガングリオシドGM3とインスリン受容体の膜貫通ペプチドの静電的相互作用解析, 二村 友香,樺山 一哉,朝比奈 雄也,花島 慎弥,北條 裕信,村田 道雄,深瀬 浩一, 生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, Vol. 2017年度, p. [3P-0030], 2017/12
  • 脂質‐タンパク質相互作用の解明を目指した重原子化CD1dリガンドの合成と生理活性の評価, 花島慎弥,HOSSAIN Imran,HOSSAIN Imran,土川博史,村田道雄,村田道雄,日下裕規,喜多俊介,前仲勝実, 日本薬学会年会要旨集(CD-ROM), Vol. 137年会, No. 1, p. 137-137, 2017/03
  • 蛍光分光法を用いた生体モデル膜中におけるガングリオシドGM3とタンパク質EGFR膜貫通ドメインの相互作用解析, 中野幹人,花島慎弥,原利明,村田道雄,村田道雄,樺山一哉,深瀬浩一,安藤弘宗,安藤弘宗,木曽真,木曽真,鈴木健一, 日本化学会春季年会講演予稿集(CD-ROM), Vol. 97th, 2017
  • CD1dの一本鎖化による安定化と結晶構造解析, 日下裕規,喜多俊介,HOSSAIN Imuran Md,花島慎弥,井貫晋輔,新山真由美,杉山成,尾瀬農之,黒木喜美子,藤本ゆかり,村田道雄,前仲勝実, 日本蛋白質科学会年会プログラム・要旨集, Vol. 17th, 2017
  • 極長鎖スフィンゴミエリンの脂質モデル膜に与える影響と相挙動解析, 森内舞,土川博史,花島慎弥,安田智一,安田智一,村田道雄,村田道雄,松森信明,松森信明,PETER Slotte J., 日本化学会春季年会講演予稿集(CD-ROM), Vol. 96th, 2016
  • 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発, 中根崇智,花島慎弥,鈴木守,鈴木守,斎木悠,林太一,垣之内啓介,垣之内啓介,杉山成,杉山成,川竹悟史,川竹悟史,松岡茂,松岡茂,松森信明,南後恵理子,小林淳,島村達郎,木村香菜子,森千寿,国島直樹,菅原道泰,高久陽子,井上茂之,井上茂之,桝田哲哉,桝田哲哉,保坂俊彰,登野健介,城地保昌,亀島敬,初井宇記,矢橋牧名,井上豪,濡木理,岩田想,岩田想,村田道雄,村田道雄,溝端栄一, 日本結晶学会年会講演要旨集, Vol. 2016, 2016
  • Crystal structure of human CD1d-β2m produced by silkworm-baculovirus expression system, Kita S,Kusaka H,Yoshida K,Kasai Y,Niiyama M,Hanashima S,Sugiyama S,Murata M,Kuroki K,Maenaka K, CD1-MR1-2015, 2015/11
  • 膜タンパク質研究基盤の構築に向けた合成リン脂質の利用, 杉山成,斎木悠,島田真典,垣ノ内啓介,垣ノ内啓介,新山真由美,新山真由美,花島慎弥,溝端栄一,井上豪,松森信明,村田道雄,村田道雄, 日本蛋白質科学会年会プログラム・要旨集, Vol. 15th, 2015
  • 多様な糖鎖結合能をもつヒトZG16pレクチンの相互作用様式の研究, 金川真由美,YAN Liu,花島慎弥,花島慎弥,池田明美,WENGANG Chai,中野佑妃子,中野佑妃子,相川京子,相川京子,TEN Feizi,山口芳樹, 日本生化学会大会(Web), Vol. 87th, 2014
  • Sup35天然変性領域のアミロイド構造多形形成機構の解明, 大橋祐美子,大橋祐美子,山口芳樹,鎌足雄司,花島慎弥,桑田一夫,田中元雅, Abstracts. Annual Meeting of the NMR Society of Japan, Vol. 53rd, 2014
  • βグルカンオリゴ糖の合成とその生物機能評価, 田中浩士,河合徹也,安達禎之,花島慎弥,山口芳樹,大野尚仁,高橋孝志,高橋孝志, 天然有機化合物討論会講演要旨集(Web), Vol. 56th, 2014
  • ヒト及び根瘤菌α1,6-fucosyltransferaseを用いたジフコシル化キトオリゴ糖の合成, 井原秀之,花島慎弥,塚本宏樹,山口芳樹,谷口直之,池田義孝, 日本生化学会大会(Web), Vol. 85th, 2012
  • Synthesis of bisubstrate type inhibitor of N-acetylglucosaminyltransferases using polymer-resin hybrid strategy, S Hanashima,S Manabe,K Inamori,N Taniguchi,Y Ito, GLYCOBIOLOGY, OXFORD UNIV PRESS INC, Vol. 14, No. 11, p. 1075-1075, 2004/11
  • Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats, T. Tsuruma,H. Sahara,M. Takenouchi,A. Yagihashi,Y. Iwayama,H. Shima,T. Furuhata,T. Torigoe,S. Hanashima,T. Yamazaki,F. Sugawara,Y. Mizushina,K. Ohta,K. Sakaguchi,N. Sato,K. Hirata, Transplantation Proceedings, Vol. 36, No. 7, p. 1965-1969, 2004/09
  • Synthesis of Bisubstrate Type Inhibitor of <i>N</i>-Acetylglucosaminyltransferases, Hanashima Shinya,Manabe Shino,Ito Yukishige, Proceedings of the Symposium on Progress in Organic Reactions and Syntheses, 日本薬学会化学系薬学部会, Vol. 30, No. 0, p. 292-293, 2004
  • ビオチン化リトコール酸を用いた,ほ乳類DNAポリメラーゼα・βのアフィニティークロマトグラフィー, 渡辺まどか,花島慎弥,水品善之,吉田弘美,大重真彦,坂口謙吾,菅原二三男, 日本農芸化学会大会講演要旨集, Vol. 2002, 2002/03/05
  • 8 Novel Methodology for Polymer Supported Oligosaccharide Synthesis, Manabe Shino,Ando Hiromune,Hanashima Shinya,Nakahara Yoshiaki,Ito Yukishige, Symposium on the Chemistry of Natural Products, symposium papers, Symposium on the Chemistry of Natural Products Steering Committee, Vol. 43, No. 0, p. 43-48, 2001
  • Inhibitory effect of mixed lymphocyte reaction by synthetic sulfolipids which are stereoisomers of sulfonoquinovosyldiacylglycerol derived from sea urchin, Y.Matsumoto,H.Sahara,T.Fujita,S.Hanashima,T.Yamazaki,S.Takahashi,Y.Mizushina,K.Ohta,F.Sugawara,K.Sakaguchi,M.Mori,S.Gasa,K.Jimbow,N.Takahashi,N.Sato, Bull. Marine Biomed. Inst., Sappro Med. Univ., Vol. 4, p. 19-23, 1999
  • Approach of chemical biology : A case study on sulfolipids, F.Sugawara,S.Hanashima,Y.Mizushina,T.Yamazaki,K.Ohta,M.Okada,T.Yamagata,K.Sakaguchi,S.Takahashi,H.Koshino,H.Sahara, Bull. Marine Biomed. Inst., Sappro Med. Univ., Vol. 4, p. 7-18, 1999

Industrial Property Rights

  • 重原子化化合物、膜タンパク質の結晶化を促進するための組成物、および該組成物を用いた膜タンパク質の構造解析方法, 杉山 成,花島 慎弥,溝端 栄一,村田 道雄,井上 豪,斎木 悠,島田 真典,松森 信明, JP2017007540, 出願日:2017/02/27
  • 糖鎖合成方法および糖鎖自動合成装置, 眞鍋 史乃,花島 慎弥,伊藤 幸成,山口 真範,田中 浩二,濱崎 勇二, 特願2005-257095, 出願日:2005/09/05

Awards

  • 日本糖質学会奨励賞, 花島 慎弥, 日本糖質学会, 2011/08
  • GlycoTokyo 奨励賞, 花島 慎弥, 東京糖鎖研究会, 2009/10

Committee Memberships

  • 日本糖質学会, 評議員, 2021/07 - Present
  • Trends in Glycoscience and Glycotechnology誌 編集委員, 2020/01 - Present
  • FCCA, 幹事, 2019/10 - Present