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Ogawa Hidesato

小川 英知

Graduate School of Frontier Biosciences, Associate Professor

keyword ARIP4/Rad54L2,p62/SQSTM1,autophagy,gene delivery,ATPase,SF-1,Ad4BP,SUMO

Education

  • 1994/04 - 1999/03, 国立奈良先端科学技術大学院大学
  • 1990/04 - 1994/03, Doshisha University
  • 1986/04 - 1989/03, 大阪府立豊中高校

Research History

  • 2016/04 - Present, 大阪大学大学院, 生命機能研究科, 特任准教授
  • 2011/04 - 2016/03, 情報通信研究機構, 未来ICT研究所, 主任研究員
  • 2008/08 - 2011, National Institute of Information and Communications Technology
  • 2002/02 - 2008/07, National Institute for Basic Biology

Research Areas

  • Life sciences, Medical biochemistry
  • Life sciences, Cell biology
  • Life sciences, Molecular biology

Professional Memberships

  • JAPAN SOCIETY FOR CELL BIOLOGY
  • The Japan Endocrine Society
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Papers

  • THOC4 regulates energy homeostasis by stabilizing TFEB mRNA during prolonged starvation, Toshiharu Fujita,Sayaka Kubo,Tatsuya Shioda,Ayaka Tokumura,Satoshi Minami,Megumi Tsuchiya,Yoshitaka Isaka,Hidesato Ogawa,Maho Hamasaki,Li Yu,Tamotsu Yoshimori,Shuhei Nakamura, Journal of Cell Science, The Company of Biologists, 2021/03/15
  • A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice., Kensuke Ihara,Tetsuo Sasano,Yuichi Hiraoka,Marina Togo-Ohno,Yurie Soejima,Motoji Sawabe,Megumi Tsuchiya,Hidesato Ogawa,Tetsushi Furukawa,Hidehito Kuroyanagi, Scientific reports, Vol. 10, No. 1, p. 17894-17894, 2020/10/27
  • Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells., Paweł Leszczyński,Magdalena Śmiech,Aamir Salam Teeli,Effi Haque,Robert Viger,Hidesato Ogawa,Mariusz Pierzchała,Hiroaki Taniguchi, International journal of molecular sciences, Vol. 21, No. 19, 2020/09/29
  • Possible Mechanisms for Maintenance and Regression of Corpus Luteum Through the Ubiquitin-Proteasome and Autophagy System Regulated by Transcriptional Factors, Aamir S. Teeli,Pawel Leszczynski,Narayanan Krishnaswamy,Hidesato Ogawa,Megumi Tsuchiya,Magdalena Smiech,Dariusz Skarzynski,Hiroaki Taniguchi, FRONTIERS IN ENDOCRINOLOGY, FRONTIERS MEDIA SA, Vol. 10, 2019/11
  • Shelterin promotes tethering of late replication origins to telomeres for replication-timing control, Shiho Ogawa,Sayuri Kido,Tetsuya Handa,Hidesato Ogawa,Haruhiko Asakawa,Tatsuro S. Takahashi,Takuro Nakagawa,Yasushi Hiraoka,Hisao Masukata, EMBO JOURNAL, WILEY, Vol. 37, No. 15, 2018/08
  • p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy, Megumi Tsuchiya,Hidesato Ogawa,Takako Koujin,Chie Mori,Hiroko Osakada,Shouhei Kobayashi,Yasushi Hiraoka,Tokuko Haraguchi, FEBS OPEN BIO, WILEY, Vol. 8, No. 3, p. 470-480, 2018/03
  • Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains, Ichiro Takada,Megumi Tsuchiya,Kaori Yanaka,Shinya Hidano,Sayuri Takahashi,Takashi Kobayashi,Hidesato Ogawa,Sinichi Nakagawa,Makoto Makishima, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 497, No. 2, p. 597-604, 2018/03
  • Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids, Takashi Baba,Hiroyuki Otake,Miki Inoue,Tetsuya Sato,Yasuhiro Ishihara,Ju-Yeon Moon,Megumi Tsuchiya,Kanako Miyabayashi,Hidesato Ogawa,Yuichi Shima,Lixiang Wang,Ryuichiro Sato,Takeshi Yamazaki,Mikita Suyama,Masatoshi Nomura,Man Ho Choi,Yasuyuki Ohkawa,Ken-ichirou Morohashi, COMMUNICATIONS BIOLOGY, NATURE PUBLISHING GROUP, Vol. 1, No. 1, 2018
  • Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth, Jhih-Siang Syu,Takashi Baba,Jyun-Yuan Huang,Hidesato Ogawa,Chi-Han Hsieh,Jin-Xian Hu,Ting-Yu Chen,Tzu-Chien Lin,Megumi Tsuchiya,Ken-Ichirou Morohashi,Bu-Miin Huang,Fu-I. Lu,Chia-Yih Wang, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 7, No. 1, 2017/03
  • A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis, Megumi Tsuchiya,M. Rezaul Karim,Taro Matsumoto,Hidesato Ogawa,Hiroaki Taniguchi, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, JOURNAL OF VISUALIZED EXPERIMENTS, No. 119, 2017/01
  • Depletion of autophagy receptor p62/SQSTM1 enhances the efficiency of gene delivery in mammalian cells, Megumi Tsuchiya,Hidesato Ogawa,Takako Koujin,Shouhei Kobayashi,Chie Mori,Yasushi Hiraoka,Tokuko Haraguchi, FEBS LETTERS, WILEY-BLACKWELL, Vol. 590, No. 16, p. 2671-2680, 2016/08
  • Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice, Ryo Nakamura,Kazuko Koshiba-Takeuchi,Megumi Tsuchiya,Mizuyo Kojima,Asuka Miyazawa,Kohei Ito,Hidesato Ogawa,Jun K. Takeuchi, DEVELOPMENT GROWTH & DIFFERENTIATION, WILEY, Vol. 58, No. 4, p. 367-382, 2016/05
  • Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation, Megumi Tsuchiya,Shin Isogai,Hiroaki Taniguchi,Hidehito Tochio,Masahiro Shirakawa,Ken-ichirou Morohashi,Yasushi Hiraoka,Tokuko Haraguchi,Hidesato Ogawa, SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, Vol. 5, 2015/09
  • Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1, Takashi Baba,Hiroyuki Otake,Tetsuya Sato,Kanako Miyabayashi,Yurina Shishido,Chia-Yih Wang,Yuichi Shima,Hiroshi Kimura,Mikako Yagi,Yasuhiro Ishihara,Shinjiro Hino,Hidesato Ogawa,Mitsuyoshi Nakao,Takeshi Yamazaki,Dongchon Kang,Yasuyuki Ohkawa,Mikita Suyama,Bon-Chu Chung,Ken-Ichirou Morohashi, NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, Vol. 5, 2014/04
  • Aristaless Related Homeobox Gene, Arx, Is Implicated in Mouse Fetal Leydig Cell Differentiation Possibly through Expressing in the Progenitor Cells, Kanako Miyabayashi,Yuko Katoh-Fukui,Hidesato Ogawa,Takashi Baba,Yuichi Shima,Noriyuki Sugiyama,Kunio Kitamura,Ken-ichirou Morohashi, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 8, No. 6, 2013/06
  • Exportin 4 Interacts with Sox9 through the HMG Box and Inhibits the DNA Binding of Sox9, Megumi Tsuchiya,Hidesato Ogawa,Taiga Suzuki,Noriyuki Sugiyama,Tokuko Haraguchi,Yasushi Hiraoka, PLOS ONE, PUBLIC LIBRARY SCIENCE, Vol. 6, No. 10, 2011/10
  • Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads, Masatomo Kusaka,Yuko Katoh-Fukui,Hidesato Ogawa,Kanako Miyabayashi,Takashi Baba,Yuichi Shima,Noriyuki Sugiyama,Yukihiko Sugimoto,Yasushi Okuno,Ryuji Kodama,Akiko Iizuka-Kogo,Takao Senda,Toshikuni Sasaoka,Kunio Kitamura,Shinichi Aizawa,Ken-ichirou Morohashi, ENDOCRINOLOGY, OXFORD UNIV PRESS INC, Vol. 151, No. 12, p. 5893-5904, 2010/12
  • Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated Nuclear Receptor Ad4BP/SF-1, Hidesato Ogawa,Tomoko Komatsu,Yasushi Hiraoka,Ken-ichirou Morohashi, MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 20, No. 19, p. 4235-4245, 2009/10
  • Generation of Rat Monoclonal Antibodies Specific for Ad4BP/SF-1, Chikako Yokoyama,Tomoko Komatsu,Hidesato Ogawa,Ken-ichirou Morohashi,Masayuki Azuma,Taro Tachibana, HYBRIDOMA, MARY ANN LIEBERT, INC, Vol. 28, No. 2, p. 113-119, 2009/04
  • Mechanism of asymmetric ovarian development in chick embryos, Yoshiyasu Ishimaru,Tomoko Komatsu,Megumi Kasahara,Yuko Katoh-Fukui,Hidesato Ogawa,Yoshiro Toyama,Mamiko Maekawa,Kiyotaka Toshimori,Roshantha A. S. Chandraratna,Ken-Ichirou Morohashi,Hidefumi Yoshioka, DEVELOPMENT, COMPANY BIOLOGISTS LTD, Vol. 135, No. 4, p. 677-685, 2008/02
  • Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600, KW Huh,J DeMasi,H Ogawa,Y Nakatani,PM Howley,K Munger, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 102, No. 32, p. 11492-11497, 2005/08
  • Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9, T Komatsu,H Mizusaki,T Mukai,H Ogawa,D Baba,M Shirakawa,S Hatakeyama,KI Nakayama,H Yamamoto,A Kikuchi,KI Morohashi, MOLECULAR ENDOCRINOLOGY, ENDOCRINE SOC, Vol. 18, No. 10, p. 2451-2462, 2004/10
  • Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA, H Ogawa,RT Yu,T Haraguchi,Y Hiraoka,Y Nakatani,K Morohashi,K Umesono, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, Vol. 320, No. 1, p. 218-225, 2004/07
  • Coordinated histone modifications mediated by a CtBP co-repressor complex, YJ Shi,J Sawada,GC Sui,EB Affar,Whetstine, JR,F Lan,H Ogawa,MPS Luke,Y Nakatani,Y Shi, NATURE, NATURE PUBLISHING GROUP, Vol. 422, No. 6933, p. 735-738, 2003/04
  • A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G(0) cells, H Ogawa,K Ishiguro,S Gaubatz,DM Livingston,Y Nakatani, SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, Vol. 296, No. 5570, p. 1132-1136, 2002/05
  • Redox-dependent regulation of nuclear import of the glucocorticoid receptor, Kensaku Okamoto,Hirotoshi Tanaka,Hidesato Ogawa,Yuichi Makino,Hidetaka Eguchi,Shin-Ichi Hayashi,Noritada Yoshikawa,Lorenz Poellinger,Kazuhiko Umesono,Isao Makino, Journal of Biological Chemistry, Vol. 274, No. 15, p. 10363-10371, 1999/04/09
  • Efficient targeting of gene expression in chick embryos by microelectroporation, Tsuyoshi Momose,Akane Tonegawa,Jun Takeuchi,Hidesato Ogawa,Kazuhiko Umesono,Kunio Yasuda, Development Growth and Differentiation, Vol. 41, No. 3, p. 335-344, 1999
  • Intracellular localization and transcriptional activation by the human glucocorticoid receptor-green fluorescent protein (GFP) fusion proteins, H Ogawa,K Umesono, ACTA HISTOCHEMICA ET CYTOCHEMICA, JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY, Vol. 31, No. 4, p. 303-308, 1998
  • A bacterial cloning vector using a mutated Aequorea green fluorescent protein as an indicator, Satoshi Inouye,Hidesato Ogawa,Kunio Yasuda,Kazuhiko Umesono,Frederick I. Tsuji, Gene, Vol. 189, No. 2, p. 159-162, 1997/04/21
  • Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells, Hidesato Ogawa,Satoshi Inouye,Frederick I. Tsuji,Kunio Yasuda,Kazuhiko Umesono, Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 25, p. 11899-11903, 1995/12/05

Misc.

  • 転写因子Sox9に結合する因子Exportin4の機能解析, 土屋惠,小川英知,小川英知,原口徳子,原口徳子,平岡泰,平岡泰, 生化学, 2010
  • 転写因子Sox9に結合する因子の精製と機能解析, 土屋惠,小川英知,諸橋憲一郎,平岡泰,平岡泰, 生化学, 2008
  • G0期における遺伝子封印機構, Ishiguro Keiichiro, 実験医学, 羊土社, Vol. 20, No. 12, p. 1898-1990, 2002